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prostatic benign hyperplasia

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https://www.readbyqxmd.com/read/28718166/can-long-term-luts-bph-pharmacological-treatment-alter-the-outcomes-of-surgical-intervention
#1
REVIEW
Fabrizio Presicce, Cosimo De Nunzio, Andrea Tubaro
PURPOSE OF REVIEW: We have reviewed the available evidence on the impact of long-term pharmacological treatment of lower urinary tract symptoms on the outcomes of benign prostatic hyperplasia surgery. EVIDENCE ACQUISITION: A systematic literature search from January 1990 to May 2017 was performed. Only references in the English language and peer-reviewed manuscripts were considered. RECENT FINDINGS: Over time, the ever-increasing use of long-term pharmaceutical treatments has considerably reduced the rate of BPH surgery in most countries...
September 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28718161/frailty-and-lower-urinary-tract-symptoms
#2
REVIEW
Anne M Suskind
The incidence of both frailty and lower urinary tract symptoms, including urinary incontinence, overactive bladder, underactive bladder, and benign prostatic hyperplasia, increases with age. However, our understanding of the relationship between frailty and lower urinary tract symptoms, both in terms of pathophysiology and in terms of the evaluation and management of such symptoms, is greatly lacking. This brief review will summarize definitions and measurement tools associated with frailty and will also review the existing state of the literature on frailty and lower urinary tract symptoms in older individuals...
September 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28717651/comparison-of-nonspherical-polyvinyl-alcohol-particles-and-microspheres-for-prostatic-arterial-embolization-in-patients-with-benign-prostatic-hyperplasia
#3
Jin Ho Hwang, Sang Woo Park, Il Soo Chang, Sung Il Jung, Hae Jeong Jeon, Yong Soo Lho, Hyeong Gon Kim, Sung Hyun Paick, Hyoung Keun Park
PURPOSE: To report early results following prostatic artery embolization (PAE) and compare outcomes between nonspherical polyvinyl alcohol (PVA) particles and microspheres to treat lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH). METHODS: PAE was performed in nine patients (mean age: 78.1 years) with symptomatic BPH. Embolization was performed using nonspherical PVA particles (250-355 μm) in four patients and microspheres (300-500 μm) in five patients...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28717543/outcome-analysis-of-transurethral-resection-versus-potassium-titanyl-phosphate-photo-selective-vaporization-of-the-prostate-for-the-treatment-of-benign-prostatic-hyperplasia-a-randomized-controlled-trial-with-4-years-follow-up
#4
Bimalesh Purkait, Rahul Janak Sinha, Krishna Swamy A Srinivas, Ankur Bansal, Ashok Kumar Sokhal, Vishwajeet Singh
OBJECTIVE: Photovaporization of prostate (PVP) is a newer surgical modality of benign prostatic hyperplasia (BPH) which is gaining importance recently. There are a few randomized controlled trials that showed safety and efficacy of PVP in comparison with transurethral resection of prostate (TURP) with limited follow-up period (<2 years). Here, we are presenting a comparative study performed on potassium titanyl phosphate (KTP) PVP laser versus TURP for the treatment of BPH with long-term follow-up period...
June 2017: Turkish Journal of Urology
https://www.readbyqxmd.com/read/28712703/role-of-semi-quantitative-dynamic-contrast-enhanced-mr-imaging-in-characterization-and-grading-of-prostate-cancer
#5
See Hyung Kim, Mi Sun Choi, Mi Jung Kim, Young Hwan Kim, Seung Hyun Cho
OBJECTIVE: The study retrospectively assessed the diagnostic value of semi-quantitative dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) in characterization and grading of prostate cancer, with correlation to histopathological analysis. MATERIALS AND METHODS: 161 consecutive patients with prostate cancer underwent DCE MRI. 430 lesions, including 200 cancers with Gleason grade (GG) of 6 (n=25), 7 (n=112) and 8 or higher (n=63); 80 benign hyperplasia; and 150 healthy tissues were assessed using a histology-MRI correlation...
July 6, 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28711970/does-a-male-polycystic-ovarian-syndrome-equivalent-exist
#6
REVIEW
R Cannarella, R A Condorelli, L M Mongioì, S La Vignera, A E Calogero
The occurrence of a genetic background in the etiology of polycystic ovarian syndrome (PCOS) represents the rational basis to postulate the existence of a male PCOS equivalent. Hormonal and metabolic abnormalities have been described in male relatives of women with PCOS. These males also have a higher prevalence of early onset (<35 years) androgenetic alopecia (AGA). Hence, this feature has been proposed as a clinical sign of the male PCOS equivalent. Clinical evidence has shown that men with early onset AGA have hormonal and metabolic abnormalities...
July 15, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28708525/assessment-of-the-age-for-a-preventive-ultrasonographic-examination-of-the-prostate-in-the-dog
#7
G Mantziaras, S Alonge, M Faustini, G C Luvoni
The prostate commonly develops benign prostatic hyperplasia (BPH) in dogs over 5 years, while in aged dogs other pathological findings might be revealed by ultrasonographic exam. The aim of the present study was to estimate the most suitable age for a preventive ultrasonographic examination of the prostate in the dog. The prostate of 1003 intact male dogs of 64 different breeds, of different ages (1-18 years) and bodyweights (2-55 kg) was evaluated with ultrasound, irrespective of the reason for clinical examination...
June 8, 2017: Theriogenology
https://www.readbyqxmd.com/read/28707361/effect-of-climatic-parameters-on-acute-urinary-retention-incidence
#8
Kwang Suk Lee, Kyo Chul Koo, Seung Hwan Lee, Kang Su Cho, Chang-Hee Hong, Byung Ha Chung
OBJECTIVES: We investigated the effect of daily climatic parameters on spontaneous acute urinary retention (sAUR) and evaluated the risk factors for refractory/recurrent AUR. METHODS: A total of 4194 patients older than 40 years were diagnosed with AUR in the emergency department at Gangnam Severance Hospital, Seoul, from January 2007 to May 2016. To evaluate climatic parameters at sAUR onset, we included individuals living in the area around the hospital. We excluded patients with fever, who did not return to the hospital after the AUR episode or with AUR occurring within 2 weeks following admission for surgery or chemotherapy...
July 13, 2017: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/28705210/transcutaneous-electrical-stimulation-of-somatic-afferent-nerves-in-the-foot-relieved-symptoms-related-to-postoperative-bladder-spasms
#9
Chanjuan Zhang, Zhiying Xiao, Xiulin Zhang, Liqiang Guo, Wendong Sun, Changfeng Tai, Zhaoqun Jiang, Yuqiang Liu
BACKGROUND: Bladder spasm is a common side effect of urological surgery. Main treatment modalities include opioids or anticholinergic medication; however, bladder spasms still occur even after these interventions. Recent studies indicate that transcutaneous stimulation of the foot can result in 50% increase in bladder capacity in healthy adults, and inhibit bladder detrusor overactivity in spinal cord injured patients. In this study, we examined the effects of transcutaneous electrical stimulation of the foot on bladder spasms related symptoms...
July 13, 2017: BMC Urology
https://www.readbyqxmd.com/read/28702148/comparative-analysis-of-resected-prostate-weight-in-diabetic-and-non-diabetic-benign-prostatic-hyperplasia-patients
#10
Emadoddin Moudi, Abazar Akbarzadeh-Pasha
BACKGROUND: Benign prostatic hyperplasia (BPH) is the most common benign tumor in men. The etiology of BPH is still unresolved and multiple systems are likely to be involved. The effects of diabetes on urinary system are a risk factor for BPH. We then assessed the effects of diabetes on the parameters related to BPH, especially weight and volume. METHODS: This study was conducted on patients with BPH who underwent surgery during 2010-2013. The patients' demographic and clinical data including age, height, weight, history of diabetes, abdominal sonography, prostate-specific antigen(PSA), fasting blood sugar (FBS), triglyceride, and cholesterol, resected sample weight, and pathological diagnosis were extracted...
2017: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/28701765/the-cancer-associated-cell-migration-protein-tspan1-is-under-control-of-androgens-and-its-upregulation-increases-prostate-cancer-cell-migration
#11
Jennifer Munkley, Urszula L McClurg, Karen E Livermore, Ingrid Ehrmann, Bridget Knight, Paul Mccullagh, John Mcgrath, Malcolm Crundwell, Lorna W Harries, Hing Y Leung, Ian G Mills, Craig N Robson, Prabhakar Rajan, David J Elliott
Cell migration drives cell invasion and metastatic progression in prostate cancer and is a major cause of mortality and morbidity. However the mechanisms driving cell migration in prostate cancer patients are not fully understood. We previously identified the cancer-associated cell migration protein Tetraspanin 1 (TSPAN1) as a clinically relevant androgen regulated target in prostate cancer. Here we find that TSPAN1 is acutely induced by androgens, and is significantly upregulated in prostate cancer relative to both normal prostate tissue and benign prostate hyperplasia (BPH)...
July 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28699307/new-surgical-instruction-method-for-homium-laser-enucleation-of-the-prostate-hand-grab-navigated-technique-to-shorten-the-learning-curve-the-results-of-multicenter-analysis
#12
Dong Gil Shin, Hyeon Woo Kim, Sung Woo Park, Chang Soo Park, Seong Choi, Tae Hee Oh, Dong Hwan Lee, Chang Yell Lee, Jung Man Kim, Jeong Zoo Lee
OBJECTIVES: To introduce a new surgical mentorship, the "hand-grab navigated technique," to shorten the learning curve for Holmium laser enucleation of the prostate. METHODS: Patients with benign prostatic hyperplasia were managed at six institutions with Holmium laser enucleation of the prostate. An analysis was done in the 200 of these patients (the set of first 20 patients treated with Holmium laser enucleation of the prostate by 10 surgeons) who were sorted into two groups depending on the surgeon's instructional group...
July 11, 2017: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/28698137/ssecks-akap12-induces-repulsion-between-human-prostate-cancer-and-microvessel-endothelial-cells-through-the-activation-of-semaphorin-3f
#13
Wen Xie, Wei Su, Lijuan Zhang, Qingkun Shang, Bing Su
Metastasis remains the primary cause of prostate cancer related death. Cancer cells need to contact endothelial cells and disrupt endothelial junctions to cross the endothelium for invasion and metastasis. The suppression of heterotypic repulsion between cancer and endothelial cells allows cancer cells to invade into the surrounding tissue. Here, we demonstrate that SSeCKS/AKAP12 induced repulsion between human prostate cancer and microvessel endothelial cells, which was mediated by an angiogenesis inhibitor Semaphorin 3F...
July 8, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28694823/the-persistence-of-silodosin-monotherapy-and-the-reasons-for-withdrawal-from-treatment-of-previously-untreated-japanese-patients-with-lower-urinary-tract-symptoms-suggestive-of-benign-prostatic-hyperplasia
#14
Yoshinori Tanaka, Yasushi Tanuma, Naoya Masumori
OBJECTIVES: The persistence of silodosin and the reasons for withdrawal from treatment of previously untreated Japanese patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia (LUTS/BPH) were evaluated in real-life clinical practice. METHODS: A total of 81 previously untreated Japanese patients diagnosed with LUTS/BPH were treated with silodosin monotherapy and prospectively followed for 4 years. The persistence rate was estimated using the Kaplan-Meier method...
2017: Advances in Urology
https://www.readbyqxmd.com/read/28694768/the-androgen-receptor-plays-different-roles-in-macrophage-induced-proliferation-in-prostate-stromal-cells-between-transitional-and-peripheral-zones-of-benign-prostatic-hypertrophy
#15
Dongliang Xu, Xingjie Wang, Chenyi Jiang, Yuan Ruan, Shujie Xia, Xiaohai Wang
Macrophages play a critical role in the process of excessive stromal proliferation of benign prostatic hyperplasia (BPH). In our previous study, we used a BPH mouse model to elucidate a potential mechanism whereby macrophage infiltration promotes stromal cell proliferation in the prostate via the androgen receptor (AR)/inflammatory cytokine CCL3-dependent pathway. In our present study, we used the co-culture system of human macrophages and various prostatic zone stromal cells to further demonstrate that infiltrating macrophages promote prostatic stromal cell proliferation through stromal AR-dependent pathways, and we show that the stroma of TZ and PZ respond to macrophages differently because of differences in stromal AR signaling; this could possibly be one of the key pathways for stromal expansion during BPH development and progression...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28685198/-geriatric-urology-increasingly-important-in-urological-care
#16
REVIEW
A Wiedemann
Urology will benefit by demographic change more than other disciplines in the next 10 years. Both number of patients and their intensity of treatment will increase. This implies the need of a reorientation of urology away from oncologic topics towards geriatric urology. Relevant issues are functional disorders of the lower urinary tract, infectiology, hematuria, and benign prostate hyperplasia. The legislature of North Rhine-Westphalia has already made the first step towards geriatric urology by the foundation of the ISAR screening for each geriatric patient outside geriatrics, which constitutes the possibility of beginning an early interdisciplinary dialogue...
July 6, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28681697/analysis-of-tim-3-as-a-therapeutic-target-in-prostate-cancer
#17
Yongrui Piao, Xuanshun Jin
Tim-3 (T-cell immunoglobulin domain and mucin domain-containing molecule 3) is a newly discovered immunomodulatory protein, which plays an important role in immunity regulation. Recent evidence suggests that Tim-3 is differentially regulated in a variety of tumors and has potential as a therapeutic target. The aim of this study was to investigate the effect of Tim-3 on the development of prostate cancer. Tim-3 expressing on peripheral CD4+ T and CD8+ T cells was analyzed by flow cytometry. The relationships between Tim-3 expression and clinicopathological features were analyzed...
July 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28679181/correlation-between-lower-urinary-tract-symptoms-and-objective-measures-of-uroflowmetry
#18
Hakan Türk, Sıtkı Ün
Indroduction: Benign prostate hyperplasia (BPH) is the most commonly diagnosed benign adenoma which causes serious clinical symptoms by bladder outlet obstruction. BPH patients suffer from negative changes in their quality of life and restriction of their daily activities due to the disease symptoms. Our main objective in this study is to evaluate the relationship between BPH and LUTS as described by International Prostate Symptoms Score and objective non-invasive parameters related to BPH. MATERIALS AND METHODS: 238 Patients over 40 years with clinical BPH, LUTS and/or prostate volumes greater than 25 ml who presented to urology department were included in the study...
June 30, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28677000/bladder-cancer-diagnosis-with-ct-urography-test-characteristics-and-reasons-for-false-positive-and-false-negative-results
#19
Tony W Trinh, Daniel I Glazer, Cheryl A Sadow, V Anik Sahni, Nina L Geller, Stuart G Silverman
PURPOSE: To determine test characteristics of CT urography for detecting bladder cancer in patients with hematuria and those undergoing surveillance, and to analyze reasons for false-positive and false-negative results. METHODS: A HIPAA-compliant, IRB-approved retrospective review of reports from 1623 CT urograms between 10/2010 and 12/31/2013 was performed. 710 examinations for hematuria or bladder cancer history were compared to cystoscopy performed within 6 months...
July 4, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28673067/expected-next-generation-drugs-under-development-in-relation-to-voiding-symptoms
#20
REVIEW
Kyung Jin Chung, Benjamin I Chung
New drug development is a high-risk venture, but if successful, will bring great revenues to those willing to accept the risk. In the field of urology, in particular for lower urinary tract symptoms (LUTS), the recent successful landing of drugs (e.g., mirabegron, botulinum toxin A, and tadalafil) has resulted in increased interest in new drug development. Benign prostatic hyperplasia and overactive bladder syndrome, representative LUTS diseases, are attractive targets because of their prevalence and market size in the field of urology...
June 2017: International Neurourology Journal
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