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prostatic benign hyperplasia

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https://www.readbyqxmd.com/read/29351556/testosterone-induced-benign-prostatic-hyperplasia-rat-and-dog-as-facile-models-to-assess-drugs-targeting-lower-urinary-tract-symptoms
#1
Jing Li, Yanxin Tian, Shimeng Guo, Haifeng Gu, Qianting Yuan, Xin Xie
Benign prostatic hyperplasia (BPH) is an age-related disease, affecting a majority of elderly men worldwide. Medical management of BPH is an alternative to surgical treatment of this disease. Currently, α1-adrenergic receptor (α1-AR) antagonists are among the first line drugs to treat BPH by reducing the tension of urinary track and thus the obstructive symptoms in voiding. In drug development, old male dogs with spontaneous BPH are considered the golden standard of the animal models. However, old dogs (>6 years) are expensive and not all old dogs develop BPH...
2018: PloS One
https://www.readbyqxmd.com/read/29351269/bipolar-or-monopolar-transurethral-resection-for-benign-prostatic-hyperplasia
#2
Gabriel Inzunza, Gabriel Rada, Alejandro Majerson
INTRODUCTION: Transurethral resection is currently considered as standard endoscopic treatment for lower urinary tract obstruction due to benign hyperplasia under 80 cc. Monopolar resection loops has been traditionally used but bipolar energy has recently displaced precedent technology. The purpose of this summary is to evaluate the efficacy and safety of both technologies. METHODS: To answer this question we used Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple information sources, including MEDLINE, EMBASE, Cochrane, among others...
January 17, 2018: Medwave
https://www.readbyqxmd.com/read/29343977/cost-effectiveness-analysis-of-six-therapies-for-the-treatment-of-lower-urinary-tract-symptoms-due-to-benign-prostatic-hyperplasia
#3
James C Ulchaker, Melissa S Martinson
Objective: To conduct a cost-effectiveness analysis from payers' perspectives of six treatments for lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH) and to examine positioning of these modalities in the marketplace for the best use of health care funds and quality-of-life benefits for patients. Methods: The economic analysis was conducted with a Markov model to compare combination prescription drug therapy (ComboRx), minimally invasive therapies (MITs) including convective radiofrequency (RF) water vapor thermal therapy (Rezūm®), conductive RF thermal therapy (Prostiva®), and prostatic urethral lift (UroLift®), and invasive surgical procedures including photovaporization of the prostate (Greenlight® PVP) and transurethral resection of the prostate (TURP)...
2018: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/29341503/tadalafil-5-mg-once-daily-improves-lower-urinary-tract-symptoms-and-erectile-dysfunction-a-systematic-review-and-meta-analysis
#4
Yilin Wang, Yiping Bao, Jie Liu, Lijun Duan, Yuanshan Cui
OBJECTIVES: We carried out a systematic review and meta-analysis to assess tadalafil 5 mg once-daily for the treatment of lower urinary tract symptoms (LUTS) and erectile dysfunction (ED). METHODS: A literature review was performed to identify all published randomized double-blind, placebo-controlled trials of tadalafil 5 mg once-daily for the treatment of LUTS and ED. The search included the following databases: MEDLINE, EMBASE, and the Cochrane Controlled Trials Register...
January 2018: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/29341501/tadalafil-improves-symptoms-erectile-function-and-quality-of-life-in-patients-with-lower-urinary-tract-symptoms-suggestive-of-benign-prostatic-hyperplasia-kyu-pro-study
#5
Ryosuke Takahashi, Minoru Miyazato, Hisae Nishii, Yasuhiro Sumino, Kazuo Takayama, Masako Onzuka, Takuma Oshiro, Seiichi Saito, Naohiro Fujimoto, Hiromitsu Mimata, Masatoshi Eto
OBJECTIVES: Effect of tadalafil on lower urinary tract symptoms (LUTS), erectile function and quality of life (QoL) were prospectively evaluated in patients with benign prostatic hyperplasia (BPH) at multicenter. METHODS: Eligible men were ≥40 years who had no treatment with alpha-blocker for BPH, with total International Prostate Symptom Score (IPSS) ≥8, IPSS-QOL ≥2 and prostate volume ≥20 mL. Data were collected on age, body mass index (BMI), and prostate specific antigen (PSA)...
January 2018: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/29338688/transurethral-resection-of-the-prostate-provides-more-favorable-clinical-outcomes-compared-with-conservative-medical-treatment-in-patients-with-urinary-retention-caused-by-benign-prostatic-obstruction
#6
Yu-Hsiang Lin, Chen-Pang Hou, Tien-Hsing Chen, Horng-Heng Juang, Phei-Lang Chang, Pei-Shan Yang, Chien-Lun Chen, Ke-Hung Tsui
BACKGROUND: To evaluate the long-term surgical outcomes of patients with urinary retention (UR) caused by a benign prostatic obstruction (BPO) who underwent transurethral resection of the prostate (TURP), and compare their outcomes with those of patients who received medication without surgical intervention. METHODS: This retrospective cohort study analyzed claims data collected during the period of 1997-2012 from Taiwan's National Health Insurance Research Database...
January 16, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29332492/safety-and-efficacy-of-photoselective-vaporization-of-the-prostate-using-the-180-w-greenlight-xps-laser-system-in-patients-taking-oral-anticoagulants
#7
Alper Eken, Bülent Soyupak
Objective To evaluate the safety and efficacy of the 180-W GreenLight XPS laser system for the treatment of benign prostatic hyperplasia in patients taking oral anticoagulants. Methods All consecutive patients admitted for lower urinary tract symptoms associated with benign prostatic hyperplasia from November 2012 to October 2016 and who underwent photoselective vaporization of the prostate with the 180-W GreenLight XPS laser were included in the study. The perioperative outcomes examined were the operating time, laser time, energy usage, and duration of postoperative catheterization...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29332451/psca-rs1045531-polymorphism-and-the-risk-of-prostate-cancer-in-a-chinese-population-undergoing-prostate-biopsy
#8
Xuefeng Zhang, Qin Hu, Ye Chen, Miao Li, Huming Yin, Chenchao Zhou, Gang Li, Jianquan Hou
BACKGROUND AND PURPOSE: This study explored the association between a single-nucleotide polymorphism of prostate stem cell antigen and prostate cancer in Chinese patients undergoing prostate biopsy. MATERIALS AND METHODS: DNA from 416 patients undergoing prostate biopsy was typed for the prostate stem cell antigen rs1045531 single-nucleotide polymorphism. The frequency of the rs1045531 polymorphism in patients with prostate cancer and in patients with benign prostatic hyperplasia was compared...
December 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/29319914/aquablation-therapy-for-symptomatic-benign-prostatic-hyperplasia-single-center-experience-in-47-patients
#9
Mihir M Desai, Abhishek Singh, Shashank Abhishek, Abhishek Laddha, Harshad Pandya, Akbar N Ashrafi, Arvind P Ganpule, Claus G Roehrborn, Andrew J Thomas, Mahesh Desai, Ravindra B Sabnis
OBJECTIVE: To report procedure process improvements and confirm preserved safety and short-term effectiveness of a second-generation Aquablation device for the treatment of lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH) in 47 consecutive patients at a single institution. PATIENTS AND METHODS: Aquablation was performed in 47 patients with symptomatic BPH at a single institution. Baseline, perioperative and 3-month urinary function data were collected...
January 10, 2018: BJU International
https://www.readbyqxmd.com/read/29316005/tamsulosin-and-the-risk-of-dementia-in-older-men-with-benign-prostatic-hyperplasia
#10
Yinghui Duan, James J Grady, Peter C Albertsen, Z Helen Wu
PURPOSE: Clinicians use tamsulosin, an α1-adrenoceptor antagonist, to manage symptomatic benign prostatic hyperplasia (BPH). Because α1-adrenoceptors are also present in the brain, the potential exists for adverse effects on cognitive functions. We explored the association between tamsulosin use and dementia risk. METHODS: We used Medicare data (2006-2012) to conduct a cohort study among patients aged ≥65 years and diagnosed with BPH. Men taking tamsulosin (n = 253 136) were matched at a 1:1 ratio using propensity-scores to each of 6 comparison cohorts: patients who used no BPH-medication (n = 180 926), and patients who used the following alternative-BPH-medications: doxazosin (n = 28 581), terazosin (n = 23 858), alfuzosin (n = 17 934), dutasteride (n = 34 027), and finasteride (n = 38 767)...
January 9, 2018: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29315911/promoter-hypermethylation-of-sox11-correlates-with-adverse-clinicopathological-features-of-human-prostate-cancer
#11
Apiwat Pugongchai, Andrey Bychkov, Pichet Sampatanukul
Currently available tools for early diagnosis and prognosis of prostate cancer lack sufficient accuracy. There is a need to identify novel biomarkers for this common malignancy. SOX family genes play an important role in embryogenesis and are also implicated in various cancers. SOX11 has been recently recognized as a potential tumour suppressor that is downregulated in prostate cancer. We hypothesized that hypermethylation may be responsible for SOX11 silencing in human prostate cancer. The aim of the study was to investigate SOX11 promoter methylation in prostate adenocarcinoma by comparing it with benign prostatic hyperplasia (BPH)...
January 8, 2018: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/29315701/histological-and-quantitative-analyzes-of-the-stromal-and-acinar-components-of-normal-human-prostate-zones
#12
Edilaine F Alves, Bruno Leonardo M de Freitas Ribeiro, Waldemar S Costa, Carla B M Gallo, Francisco J B Sampaio
BACKGROUND: McNeal divided the human prostate into three major anatomical areas: the peripheral zone (PZ), the central zone (CZ), and the transition zone (TZ). Each of these areas is biologically and histologically distinct. The PZ and TZ have clinical significance and are associated with prostate cancer (PC) and benign prostatic hyperplasia (BPH), respectively. Therefore, the objective of the present study was to quantitatively and qualitatively analyze the parenchymal and stromal components that constitute the different prostate zones...
January 8, 2018: Prostate
https://www.readbyqxmd.com/read/29313161/benign-prostatic-hyperplasia-surgical-scoring-bphss-an-novel-scoring-system-for-the-perioperative-outcomes-of-holmium-laser-enucleation-of-the-prostate
#13
Huan Xu, Zhikang Cai, Yanbo Chen, Meng Gu, Qi Chen, Zhong Wang
To develop a standardized scoring system, the BPH surgical scoring (BPHSS) system, to quantify the ability to predict the perioperative outcomes resulting from an enlarged prostate. There are two parts included in this study: the retrospective observational study (875 patients treated with holmium laser enucleation of the prostate, HoLEP) and the prospective observational study (111 patient underwent HoLEP). All the outcome data included the following: the basic patient preoperative characteristics, operation time (OT), pre- and post- surgery hemoglobin decrease, Na+ variation, hospital stay duration, duration of bladder irrigation, catheterization time, and hospitalization time...
January 8, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29310154/re-prostatic-artery-embolization-for-the-treatment-of-symptomatic-benign-prostatic-hyperplasia-in-men-%C3%A2-75-years-a-prospective-single-center-study
#14
Tomas L Griebling
No abstract text is available yet for this article.
January 2018: Journal of Urology
https://www.readbyqxmd.com/read/29297496/variants-of-acinar-adenocarcinoma-of-the-prostate-mimicking-benign-conditions
#15
Peter A Humphrey
Histological variants of acinar adenocarcinoma of the prostate may be of significance due to difficulty in diagnosis or due to differences in prognosis compared to usual acinar adenocarcinoma. The 2016 World Health Organization classification of acinar adenocarcinoma includes four variants that are deceptively benign in histological appearance, such that a misdiagnosis of a benign condition may be made. These four variants are atrophic pattern adenocarcinoma, pseudohyperplastic adenocarcinoma, microcystic adenocarcinoma, and foamy gland adenocarcinoma...
January 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29288784/association-of-prostatic-volume-and-carotid-intima-media-thickness-in-patients-with-benign-prostatic-hyperplasia
#16
Ali Riza Erbay, Hüseyin Ede, Kürsad Zengin, Mustafa Fatih Erkoc, Serhat Tanık, Sebahattin Albayrak, Ertan Yetkin
OBJECTIVE: To assess cardiovascular risk factors and carotid intima-media thickness in patients with benign prostatic hyperplasia. MATERIALS AND METHODS: One hundred and twenty three patients who were evaluated for the presence of benign prostatic hyperplasia with accompanying symptoms were included in the study. Patients were also examined by cardiology department to assess and measure cardiovascular risk factors, left ventricular functions and carotid intima-media thickness...
December 27, 2017: Urology
https://www.readbyqxmd.com/read/29286311/comparative-proteomics-analysis-of-urine-reveals-down-regulation-of-acute-phase-response-signaling-and-lxr-rxr-activation-pathways-in-prostate-cancer
#17
Katarina Davalieva, Sanja Kiprijanovska, Ivana Maleva Kostovska, Sotir Stavridis, Oliver Stankov, Selim Komina, Gordana Petrusevska, Momir Polenakovic
Detecting prostate cancer (PCa) using non-invasive diagnostic markers still remains a challenge. The aim of this study was the identification of urine proteins that are sufficiently sensitive and specific to detect PCa in the early stages. Comparative proteomics profiling of urine from patients with PCa, benign prostate hyperplasia, bladder cancer, and renal cancer, coupled with bioinformatics analysis, were performed. Statistically significant difference in abundance showed 20 and 85 proteins in the 2-D DIGE/MS and label-free LC-MS/MS experiments, respectively...
December 29, 2017: Proteomes
https://www.readbyqxmd.com/read/29285392/association-between-genetic-polymorphisms-of-long-non-coding-rna-prncr1-and-prostate-cancer-risk-in-a-sample-of-the-iranian-population
#18
Hedieh Sattarifard, Mohammad Hashemi, Shekoofeh Hassanzarei, Behzad Narouie, Gholamreza Bahari
The aim of the present study was to determine whether there is an association between the long non-coding RNA (lncRNA) prostate cancer-associated non-coding RNA 1 (PRNCR1) polymorphisms and prostate cancer (PCa) risk in a sample of the Iranian population. This case-control study was performed on 178 patients with PCa and 180 subjects with benign prostatic hyperplasia (BPH). Genotyping assay was performed by polymerase chain reaction-restriction fragment length polymorphism. The findings indicated that the GG genotype of the rs13252298 A>G variant significantly increased the risk of PCa (odds ratio=3...
December 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29285211/molecular-analyses-of-prostate-tumors-for-diagnosis-of-malignancy-on-fine-needle-aspiration-biopsies
#19
Menglin Shan, Qianlin Xia, Dong Yan, Yanjun Zhu, Xuan Zhang, Guihong Zhang, Jianming Guo, Jun Hou, Weiping Chen, Tongyu Zhu, Xiaoyan Zhang, Jianqing Xu, Jin Wang, Tao Ding, Jianghua Zheng
Prostate cancer (PCa) is a common cancer and remains the second-leading cause of cancer-associated mortality in men, but diagnosis of PCa remains a main clinical challenge. To investigate the involvement of differentially expressing genes in PCa with deregulated pathways to allow earlier diagnosis of the disease, transcriptomic analyses of differential expression genes in fine-needle aspiration (FNA) biopsies helped to discriminate PCa from benign prostatic hyperplasia (BPH). We identified 255 genes that were deregulated in prostate tumors compared with BPH tissues...
December 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/29282885/effects-of-varying-degrees-of-partial-bladder-outlet-obstruction-on-urinary-bladder-function-of-rats-a-novel-link-to-inflammation-oxidative-stress-and-hypoxia
#20
Ecem Kaya Sezginer, Didem Yilmaz-Oral, Utku Lokman, Serpil Nebioglu, Fugen Aktan, Serap Gur
OBJECTIVES: The aim of the present study was to investigate the effects of different degrees of obstruction, and the roles of inflammation, oxidative stress, and hypoxia parameters on bladder function. METHODS: Thirty male Sprague-Dawley rats were divided into 3 groups (n = 10 in each group): (i) sham-operated control; (ii) severe partial bladder outlet obstruction (PBOO); and (iii) moderate PBOO. Severe and moderate PBOO were induced by urethral ligation using 3-Fr and 4-Fr catheters, respectively, for 6 weeks...
December 28, 2017: Lower Urinary Tract Symptoms
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