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https://www.readbyqxmd.com/read/28926200/dual-wavelength-assisted-thermal-hemostasis-for-treatment-of-benign-prostate-hyperplasia
#1
Jiuen Hwang, Hyejin Kim, Truong Van Gia, Jason Xuan, Thomas Hasenberg, Hyun Wook Kang
Laser treatment on a large size of prostate gland often encounters significant bleeding that can prolong the entire procedure and cause urinary complications. The current study investigates the feasibility of dual-wavelength (532 and 980 nm) application to achieve rapid hemostasis for 532-nm laser prostatectomy. Porcine kidney and bleeding phantom models were tested to quantify the degree of the irreversible tissue coagulation and to estimate the time for the complete hemostasis, respectively. The ex vivo kidney testing verifies that the dual-wavelength created up to 40% deeper and 25% wider coagulation regions than a single wavelength does...
September 19, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28905746/re-a-possible-relationship-between-serum-sex-hormones-and-benign-prostatic-hyperplasia-lower-urinary-tract-symptoms-in-men-who-underwent-transurethral-prostate-resection
#2
https://www.readbyqxmd.com/read/28905745/re-rates-of-prostate-surgery-and-acute-urinary-retention-for-benign-prostatic-hyperplasia-in-men-treated-with-dutasteride-or-finasteride
#3
Steven A Kaplan
No abstract text is available yet for this article.
October 2017: Journal of Urology
https://www.readbyqxmd.com/read/28904902/technique-considerations-and-complication-management-in-transurethral-resection-of-the-prostate-and-photoselective-vaporization-of-the-prostate
#4
REVIEW
Charles Welliver, Sevann Helo, Kevin T McVary
The prevalence of lower urinary tract symptoms (LUTS) and benign prostatic hyperplasia (BPH) increases with age. While a variety of treatments are available for these men, endoscopic treatments are generally preferred for men with small to moderate size glands. Novel treatment options are continually introduced into this large market. However, the practicing urologist should have a well tested surgical option in regular practice that is applicable to a wide range of patients. Herein we discuss two well recognized surgical options that can be used for the majority of men with LUTS due to BPH who have failed medical management...
August 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28903581/geriatric-assessment-can-predict-outcomes-of-endoscopic-surgery-for-benign-prostatic-hyperplasia-in-elderly-patients
#5
Thomas Pichon, Cyrille Launay, Thibaut Culty, Denis Chautard, Nadine Collet, Nicolas Hoareau, Elena Brassart, Pierre Bigot, Olivier Beauchet, Abdel-Rahmene Azzouzi, Arnaud Cerruti, Souhil Lebdai
Ojectives: Surgical management of benign prostatic hyperplasia (BPH) in elderly patients is associated with higher morbidity and mortality. This arises the question of benefice and risk balance. We conducted a prospective observational study to evaluate the results of endoscopic surgery for BPH in elderly patients, according to geriatric assessment. PATIENTS AND METHODS: We included prospectively 60 patients over 75 years, with an indwelling catheter for acute or chronic retention, who were candidates to endoscopic surgery for BPH...
September 13, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28903364/kif7-attenuates-prostate-tumor-growth-through-lkb1-mediated-akt-inhibition
#6
Kai Yau Wong, Jing Liu, Kwok Wah Chan
This study investigated kinesin family member 7 (KIF7) expression and function in prostate cancer (PCa). Our results showed that KIF7 was significantly downregulated in PCa, compared with normal, benign prostatic hyperplasia and prostate intraepithelial neoplasia tissues, partially through promoter hypermethylation. We further investigated the effects of KIF7 coiled coil (CC) domain and motor domain (MD) on PCa development in vitro and in vivo. Our results showed that KIF7-CC but not KIF7-MD significantly attenuated proliferation and colony formation, impeded migration and invasion, induced apoptosis and sensitized PCa cells to paclitaxel...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28902866/5-year-long-term-efficacy-of-120-w-greenlight-photoselective-vaporization-of-the-prostate-for-benign-prostate-hyperplasia
#7
Juhyun Park, Sung Yong Cho, Min Chul Cho, Hyeon Jeong, Hwancheol Son
PURPOSE: To investigate 5-year long-term postoperative efficacy in benign prostate hyperplasia (BPH) following 120-W GreenLight high-performance system photoselective vaporization of the prostate (HPS-PVP). METHODS: This was a retrospective study of surgical outcomes in 159 men who underwent HPS-PVP and were followed over 60 months postoperatively. Definitions of treatment success were established based on the following three variables: international prostate symptom scores (IPSS), maximum flow rates (Qmax), and quality of life scores QoL)...
2017: PloS One
https://www.readbyqxmd.com/read/28899491/association-between-selenium-and-lycopene-supplementation-and-incidence-of-prostate-cancer-results-from-the-post-hoc-analysis-of-the-procomb-trial
#8
Giuseppe Morgia, Salvatore Voce, Fabiano Palmieri, Marcello Gentile, Gennaro Iapicca, Antonella Giannantoni, Franco Blefari, Marco Carini, Giuseppe Vespasiani, Giorgio Santelli, Salvatore Arnone, Rosaria M Pareo, Giorgio Ivan Russo
BACKGROUND: Many potential chemopreventive agents have been used in PCa prevention, including selenium (Se) and lycopene (Ly). However, their role has been matter of debate over the years, due to potential of promotion of PCa. PURPOSE: In this study we aimed at evaluating the incidence risk of prostate cancer (PCa) in a cohort of patients treated with Se and Ly. METHODS: The Procomb trial design has been previously published (ISRCTN78639965)...
October 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28899370/resource-utilization-and-costs-associated-with-the-addition-of-an-antimuscarinic-in-patients-treated-with-an-alpha-blocker-for-the-treatment-of-urinary-symptoms-linked-to-benign-prostatic-hyperplasia
#9
Antoni Sicras-Mainar, Ruth Navarro-Artieda, Ana Mª Mora, Marta Hernández
No abstract text is available yet for this article.
September 12, 2017: BMC Urology
https://www.readbyqxmd.com/read/28889714/-clinical-study-of-holep-for-the-patients-with-benign-prostatic-hyperplasia-who-are-on-oral-antithrombotics
#10
Takashi Matuoka, Issei Suzuki, Ryosuke Suzuki, Arinobu Fukunaga, Yoichiro Dohi, Yoshio Sugino, Koji Inoue, Mutsushi Kawakita
Recently, holmium laserenucleation of the prostate (HoLEP) was associated with less bleeding compared with transurethral resection of prostate. Since 2012, we have performed HoLEP for benign prostatic hyperplasia (BPH) under continuous oral antithrombotics (OA). Between October 2004 and March 2015, 54 patients with BPH underwent HoLEP while on OA at our hospital. Eight patients underwent HoLEP without OA cessation and 46 patients with temporary OA cessation. No significant between-group difference was observed in age, prostate volume, transitional zone prostate volume, operation time, resection weight, resection weight per minute, urethral catheter duration, Hb decrease on day 1 post- HoLEP, hospital stay after HoLEP, bleeding intraoperative rate, bleeding rate after HoLEP and transfusion rate...
August 2017: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/28882779/safety-and-effectiveness-of-holmium-laser-enucleation-of-the-prostate-using-a-low-power-laser
#11
Shingo Minagawa, Shinsuke Okada, Hirofumi Morikawa
OBJECTIVE: To assess the safety and effectiveness of holmium laser enucleation of the prostate (HoLEP) using a low-power 30 W holmium laser with an en-bloc enucleation technique. METHODS: We retrospectively analyzed 74 patients with a diagnosis of benign prostatic hyperplasia treated with HoLEP using a 30 W laser set at 1.5 J with a frequency of 20 Hz, as a low-power setting. The enucleation process was performed using the en-bloc technique. Forty-four patients were operated on by an experienced surgeon, while 30 patients were operated on by 2 less experienced surgeons...
September 4, 2017: Urology
https://www.readbyqxmd.com/read/28882566/genetic-variations-in-ugt2b28-ugt2b17-ugt2b15-genes-and-the-risk-of-prostate-cancer-a-case-control-study
#12
Mohsen Habibi, Reza Mirfakhraie, Maryam Khani, Azadeh Rakhshan, Eznollah Azargashb, Farkhondeh Pouresmaeili
Glucuronidation is a major pathway for elimination of exogenous and endogenous compounds such as environmental carcinogens and androgens from the body. This biochemical pathway is mediated by enzymes called uridine diphosphoglucuronosyltransferases (UGTs). Null (del/del) genes polymorphisms in UGT2B17, and UGT2B28 and D85Y single-nucleotide polymorphism (SNP) of UGT2B15 have been reported to increase the risk of prostate cancer. The goal of this study was to determine the association of mentioned genetic variants with the risk of prostate cancer...
September 4, 2017: Gene
https://www.readbyqxmd.com/read/28881726/modulation-of-paracrine-signaling-by-cd9-positive-small-extracellular-vesicles-mediates-cellular-growth-of-androgen-deprived-prostate-cancer
#13
Carolina Soekmadji, James D Riches, Pamela J Russell, Jayde E Ruelcke, Stephen McPherson, Chenwei Wang, Chris M Hovens, Niall M Corcoran, Michelle M Hill, Colleen C Nelson
Proliferation and maintenance of both normal and prostate cancer (PCa) cells is highly regulated by steroid hormones, particularly androgens, and the extracellular environment. Herein, we identify the secretion of CD9 positive extracellular vesicles (EV) by LNCaP and DUCaP PCa cells in response to dihydrotestosterone (DHT) and use nano-LC-MS/MS to identify the proteins present in these EV. Subsequent bioinformatic and pathway analyses of the mass spectrometry data identified pathologically relevant pathways that may be altered by EV contents...
August 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28881614/autophagy-deactivation-is-associated-with-severe-prostatic-inflammation-in-patients-with-lower-urinary-tract-symptoms-and-benign-prostatic-hyperplasia
#14
Cosimo De Nunzio, Simona Giglio, Antonella Stoppacciaro, Mauro Gacci, Roberto Cirombella, Emidio Luciani, Andrea Tubaro, Andrea Vecchione
Autophagy is a conserved evolutionary process that allows cells to maintain macromolecular synthesis and energy homeostasis during starvation and stressful conditions. We prospectively evaluated the relationship between autophagy and prostatic inflammation in a series of transurethral prostatic resection samples. Inflammatory infiltrates were defined according to the standardized classification of chronic prostatitis of the National Institute of Health. The inflammatory score (IS score) was calculated. High IS score was defined as ≥7...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28879692/safety-and-effectiveness-of-once-daily-tadalafil-5-mg-therapy-in-korean-men-with-benign-prostatic-hyperplasia-lower-urinary-tract-symptoms-in-a-real-world-clinical-setting-results-from-a-post-marketing-surveillance-study
#15
Ji Eon Won, Ji Yeon Chu, Hyunah Caroline Choi, Yun Chen, Hyun Jun Park, Héctor José Dueñas
PURPOSE: The aim of this study was to investigate the safety and effectiveness of tadalafil 5 mg once daily (quaque die [everyday], QD) among Korean men with benign prostatic hyperplasia (BPH)/lower urinary tract symptoms (LUTS) in a real-world clinical setting. MATERIALS AND METHODS: This was a single-country, prospective, observational cohort study in which patients newly prescribed tadalafil 5 mg QD for the treatment of BPH/LUTS were followed-up for 12±2 or 24±2 weeks, or to the last treatment, during post-marketing surveillance...
September 6, 2017: World Journal of Men's Health
https://www.readbyqxmd.com/read/28878599/clinical-importance-of-histopathological-inflammation-in-patients-with-lower-urinary-tract-symptoms-due-to-benign-prostatic-hyperplasia-a-prospective-study-of-222-patients
#16
Thibault Meert, Evert Baten, Koenraad van Renterghem
OBJECTIVE: To investigate the relationship between the severity of histopathological prostatic inflammation with lower urinary tract symptoms and prostate specific antigen (PSA) levels. METHODS: We prospectively included 222 consecutive patients eligible for transurethral resection of the prostate in a non-academic referral center by a single surgeon. Patients with proven urinary tract infection or prostate cancer were excluded. Preoperative assessment included PSA levels, International Prostate Symptom Score (IPSS), mean peak flow, mean resected prostate weight and post-residual volume...
August 2017: Current Urology
https://www.readbyqxmd.com/read/28878597/the-advantages-of-transurethral-resection-of-the-prostate-in-patients-with-an-elevated-or-rising-prostate-specific-antigen-mild-or-moderate-lower-urinary-tract-symptoms-bladder-outlet-obstruction-and-negative-prostate-cancer-imaging-or-prostate-biopsies-a-prospective
#17
Evert Baten, Koenraad van Renterghem
OBJECTIVE: To investigate elevated or rising prostate specific antigen (PSA) as a marker for bladder outlet obstruction (BOO) in patients with minor lower urinary tract symptoms (LUTS) and without prostate cancer. MATERIALS AND METHODS: One hundred and five consecutive patients were prospectively analyzed between 2005 and 2013. All patients were referred to the principal investigator by their general practitioner as a result of an elevated and/or rising PSA. Only patients with minor LUTS [International Prostate Symptom Score (I-PSS) 0-19] and without suspicion for prostate cancer were included...
August 2017: Current Urology
https://www.readbyqxmd.com/read/28878453/pulsed-electromagnetic-field-with-or-without-exercise-therapy-in-the-treatment-of-benign-prostatic-hyperplasia
#18
Hany M Elgohary, Sayed A Tantawy
[Purpose] To investigate the effect of pulsed electromagnetic field with or without exercise therapy in the treatment of benign prostatic hyperplasia. [Subjects and Methods] Sixty male patients aged 55-65 years with benign prostatic hyperplasia were invited to participate in this study. Patients were randomly assigned to Group A (n=20; patients who received pulsed electromagnetic field in addition to pelvic floor and aerobic exercises), Group B (n=20; patients who received pulsed electromagnetic field), and Group C (n=20; patients who received placebo electromagnetic field)...
August 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28877372/desquamation-takes-center-stage-at-the-origin-of-proliferative-inflammatory-atrophy-epithelial-mesenchymal-transition-and-stromal-growth-in-benign-prostate-hyperplasia
#19
Danilo Ferrucci, Manoel F Biancardi, Umar Nishan, Rafaela Rosa-Ribeiro, Hernandes F Carvalho
In this commentary we propose a relationship between desquamation, initially described as the collective detachment and deletion of epithelial cell in the prostate gland after castration, and proliferative inflammatory atrophy (PIA) and stromal growth in benign prostate hyperplasia (BPH). First, in response to diverse stimuli, including inflammatory mediators, epithelial cells desquamate and leave a large surface of the luminal side of the basement membrane (BM) exposed. Basal cells are activated into intermediate-type cells, which change morphology to cover and remodel the exposed BM (simple atrophy) to a new physiological demand (such as in the hypoandrogen environment, simulated by surgical and/or chemical castration) and/or to support re-epithelialization (under normal androgen levels)...
September 6, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28874333/prevalence-and-risk-factors-for-erectile-dysfunction-in-chinese-adult-males
#20
Xinyu Zhang, Bin Yang, Ni Li, Hongjun Li
BACKGROUND: There is a lack of nationwide epidemiologic survey data on the prevalence estimate of erectile dysfunction (ED) in Chinese men living on the mainland China. AIM: To attain the representative prevalence estimate of ED in the Chinese male population and to analyze potential risk factors associated with ED by demographics, socioeconomic status, and medical comorbidities. METHODS: The study was community based. The five-item Internation Index of Erectile Function questionnaire and in-person interview were used to obtain data...
September 2, 2017: Journal of Sexual Medicine
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