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https://www.readbyqxmd.com/read/29148067/should-theophylline-be-added-to-the-j-wave-syndrome-therapeutic-armamentarium
#1
EDITORIAL
Charles Antzelevitch, Sami Viskin
The substrate for both early repolarization syndrome (ERS) and Brugada syndrome (BrS), the so-called J wave syndromes, has been shown to develop as a consequence of genetic variants causing a loss of function of inward currents such sodium (INa ) and calcium (ICa ) channel currents or a gain of function in outward currents such as the transient outward current (Ito ). These changes in ion channel function result in an outward shift of the balance of currents active during the early phases of the epicardial action potential in the right ventricular outflow tract (RVOT) of the heart in the case BrS and in the inferior left ventricle in the case of ERS...
November 16, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29143975/sustained-cardiac-programming-by-short-term-juvenile-exercise-training-in-male-rats
#2
Y Asif, M E Wlodek, M J Black, A P Russell, P F Soeding, G D Wadley
The aim of this study was to investigate if endurance training during juvenile life 'reprograms' the heart and leads to sustained improvements in the structure, function, and morphology of the adult heart. Male Wistar Kyoto rats were exercise trained 5 days/week for four weeks in either juvenile (5-9 weeks of age), adolescent (11-15 weeks of age) or adult life (20-24 weeks of age). Juvenile exercise training, when compared to 24 week old sedentary rats, led to sustained increases in left ventricle (LV) mass (+18%; P < 0...
November 16, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29143137/segmental-biventricular-analysis-of-myocardial-function-using-high-temporal-and-spatial-resolution-tissue-phase-mapping
#3
Marius Menza, Daniela Föll, Jürgen Hennig, Bernd Jung
OBJECTIVE: Myocardial dysfunction of the right ventricle (RV) is an important indicator of RV diseases, e.g. RV infarction or pulmonary hypertension. Tissue phase mapping (TPM) has been widely used to determine function of the left ventricle (LV) by analyzing myocardial velocities. The analysis of RV motion is more complicated due to the different geometry and smaller wall thickness. The aim of this work was to adapt and optimize TPM to the demands of the RV. MATERIALS AND METHODS: TPM measurements were acquired in 25 healthy volunteers using a velocity-encoded phase-contrast sequence and kt-accelerated parallel imaging in combination with optimized navigator strategy and blood saturation...
November 15, 2017: Magma
https://www.readbyqxmd.com/read/29141964/acute-decompensated-pulmonary-hypertension
#4
Laurent Savale, Jason Weatherald, Xavier Jaïs, Constance Vuillard, Athénaïs Boucly, Mitja Jevnikar, David Montani, Olaf Mercier, Gerald Simonneau, Elie Fadel, Olivier Sitbon, Marc Humbert
Acute right heart failure in chronic precapillary pulmonary hypertension is characterised by a rapidly progressive syndrome with systemic congestion resulting from impaired right ventricular filling and/or reduced right ventricular flow output. This clinical picture results from an imbalance between the afterload imposed on the right ventricle and its adaptation capacity. Acute decompensated pulmonary hypertension is associated with a very poor prognosis in the short term. Despite its major impact on survival, its optimal management remains very challenging for specialised centres, without specific recommendations...
December 31, 2017: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/29139550/long-term-clinical-and-echocardiographic-outcomes-of-mitraclip-therapy-in-patients-non-responders-to-cardiac-resynchronization
#5
Valerio L Giaimo, Paolo Zappulla, Arianna Cirasa, Donatella Tempio, Maria Sanfilippo, Giulia Rapisarda, Danilo Trovato, Angelo Di Grazia, Claudio Liotta, Carmelo Grasso, Davide Capodanno, Corrado Tamburino, Valeria Calvi
OBJECTIVES: This study deals clinical and echocardiographic outcomes in cardiac resynchronization therapy (CRT) non-responders patients undergoing Mitraclip procedure. BACKGROUND: Functional mitral regurgitation (FMR) occurs in approximately one-third of heart failure (HF) patients. Resynchronization therapy may correct FMR in patients with HF, however significant FMR persists in 20-25% of CRT patients. METHODS: All patients included were previously treated with CRT for at least 6 months and remained classified as New York Heart Association (NYHA) functional class III or IV despite optimal medical therapy; the echocardiographic assessment showed lack of decrease of the left ventricular end systolic volume (LVESV) of at least 10% and residual moderate-to-severe or severe FMR...
November 15, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29128104/effects-of-intermedin-on-autophagy-in-cerebral-ischemia-reperfusion-injury
#6
Meng Wang, Jing Wang, Zhengang Liu, Xin Guo, Ning Wang, Nana Jia, Yanshu Zhang, Jie Yuan
OBJECTIVE: This study aimed to evaluate the effects of intermedin (IMD) on autophagy in cerebral ischemia/reperfusion (I/R) injury (CIRI). METHODS: Sixty rats were randomly averaged into four groups: sham, ischemia/reperfusion (I/R), IMD, and 3-methyladenine (3-MA). In the sham group, the right common carotid artery, external carotid artery, and internal carotid artery were detached, and no monofilament was inserted. In the other groups, two hours after cerebral ischemia, the rats were injected through the lateral ventricle with normal saline for I/R group, IMD for the IMD group, and 3-MA for the 3-MA group for 24h...
November 8, 2017: Neuropeptides
https://www.readbyqxmd.com/read/29126435/human-amnion-cells-reverse-acute-and-chronic-pulmonary-damage-in-experimental-neonatal-lung-injury
#7
Dandan Zhu, Jean Tan, Amina S Maleken, Ruth Muljadi, Siow T Chan, Sin N Lau, Kirstin Elgass, Bryan Leaw, Joanne Mockler, Daniel Chambers, Kristen T Leeman, Carla F Kim, Euan M Wallace, Rebecca Lim
BACKGROUND: Despite advances in neonatal care, bronchopulmonary dysplasia (BPD) remains a significant contributor to infant mortality and morbidity. While human amnion epithelial cells (hAECs) have shown promise in small and large animal models of BPD, there is scarce information on long-term benefit and clinically relevant questions surrounding administration strategy remain unanswered. In assessing the therapeutic potential of hAECs, we investigated the impact of cell dosage, administration routes and timing of treatment in a pre-clinical model of BPD...
November 10, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29120543/-right-heart-failure-important-forold-and-young-patientsa-challenge-from-the-acute-to-the-chronic
#8
Latifa Jedday, Véronique Trombert, Philippe Meyer, Georg Ehret, Jean-Luc Reny, Clémence Cuvelier
The prevalence of the right heart failure (RHF) is poorly known. However, RHF is often a consequence of left heart failure due to an interdependance between both ventricles. RHF should be indentified because of prognostic relevance. RHF is defined by the inability to maintain adequate cardiac output through the lung circulation. It can result from volume overload, pressure overload, or a disorder of systolic function. Adaptive mechanisms such as dilation or hyper-trophy will maintain adequate hemodynamics. Once these mechanisms become insufficient, congestive signs and hemodynamic consequences will appear...
November 8, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29118889/successful-treatment-of-iatrogenic-external-iliac-artery-perforation-with-covered-stent-case-report-and-review-of-the-literature
#9
Muhammad Umer Awan, Bassam Omar, Ghazanfar Qureshi, Ghulam Mustafa Awan
Retroperitoneal hemorrhage from iliac artery injury is a potentially serious complication of vascular interventional procedures leading to hemorrhagic shock and death if not diagnosed early and treated promptly. We report a 70-year-old male admitted to our facility with non-ST-elevation myocardial infarction, whose heart catheterization revealed left anterior descending artery (LAD) with 80% proximal, 95% mid and 100% distal disease. The left circumflex and right coronary arteries were 100% occluded proximally and received collaterals from the LAD...
October 2017: Cardiology Research
https://www.readbyqxmd.com/read/29113751/cardiomyopathy-induced-by-incessant-ventricular-tachycardia-originating-in-the-vicinity-of-the-his-bundle
#10
Sana Ouali, Manel Ben Halima, Selim Boudiche, Anissa Gharbi, Khedher Nadim, Kaouthar Hakim, Fatma Ouarda, Mohamed Sami Mourali
A 04-year-old boy was referred to our institution with severe, progressive heart failure of 4-months duration associated with a persistent wide QRS tachycardia with left bundle branch block and severe left ventricular dysfunction. Because of incessant wide QRS tachycardia refractory to antiarrhythmic drugs, he was referred for electrophysiological study. The ECG was suggestive of VT arising from the right ventricle near the His area. Electrophysiological study revealed that origin of tachycardia was septum of the right ventricle, near His bundle, however the procedure was not successful and an inadvertent complete atrioventricular conduction block occurred...
November 4, 2017: Indian Pacing and Electrophysiology Journal
https://www.readbyqxmd.com/read/29112180/impaired-right-ventricle-function-as-predictor-of-early-mortality-in-patients-with-light-chain-cardiac-amyloidosis-assessed-in-the-cardiology-department
#11
Justyna Anna Szczygieł, Piotr Zbigniew Wieczorek, Joanna Drozd-Sokołowska, Piotr Michałek, Łukasz Mazurkiewicz, Marta Legatowicz-Koprowska, Ewa Walczak, Wiesław Wiktor Jędrzejczak, Jadwiga Dwilewicz-Trojaczek, Jacek Grzybowski
INTRODUCTION    Light-chain amyloidosis (AL amyloidosis) is the most common cardiac amyloidosis. Early mortality remains a substantial problem despite progress in treatment. OBJECTIVES    The aim of the study was to obtain a clinical profile of patients diagnosed with AL amyloidosis in the cardiology department, to define an early mortality cut-off point in this population, and to identify predictors of early mortality. PATIENTS AND METHODS    The analysis covered 30 patients (14 females, median age 61...
November 3, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/29103857/phenotype-management-and-predictors-of-outcome-in-a-large-cohort-of-adult-congenital-heart-disease-patients-with-heart-failure
#12
Alexander Van De Bruaene, Edward J Hickey, Adrienne H Kovacs, Andrew M Crean, Rachel M Wald, Candice K Silversides, Andrew N Redington, Heather J Ross, Ana Carolina Alba, Filio Billia, Krishnakumar Nair, Lee Benson, Eric Horlick, Mark Osten, Jack Colman, Jane Heggie, Erwin N Oechslin, S Lucy Roche
OBJECTIVE: Although heart failure (HF) is the leading cause of premature death in adult congenital heart disease (ACHD), little population-specific data exist. This study reports early experience from a dedicated, sub-specialty adult congenital heart disease-heart failure (ACHD-HF) clinic, aiming to identify risk factors for adverse outcome. METHODS: Between 2012 and 2015, 126 patients (57% male) attended the ACHD-HF clinic. Baseline and follow-up data were analysed and compared across 4 anatomical/physiological subgroups: cyanotic ACHD, Fontan circulation (1V), biventricular circulation with a subaortic right ventricle (2V-RV) and biventricular circulation with a subaortic left ventricle (2V-LV)...
October 31, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29101495/deletion-of-cdc42-in-embryonic-cardiomyocytes-results-in-right-ventricle-hypoplasia
#13
Yang Liu, Jian Wang, Jieli Li, Rui Wang, Binu Tharakan, Shenyuan L Zhang, Carl W Tong, Xu Peng
BACKGROUND: Cdc42 is a member of the Rho GTPase family and functions as a molecular switch in regulating cytoskeleton remodeling and cell polarity establishment. Inactivating Cdc42 in cardiomyocytes resulted in embryonic lethality with heart developmental defects, including ventricular septum defects and thin ventricle wall syndrome. FINDINGS: In this study, we have generated a Cdc42 cardiomyocyte knockout mouse line by crossing Cdc42/flox mice with myosin light chain 2a (MLC2a)-Cre mice...
November 3, 2017: Clinical and Translational Medicine
https://www.readbyqxmd.com/read/29100949/plasticity-of-the-human-visual-brain-after-early-cortical-lesion
#14
K Mikellidou, R Arrighi, G Aghakhanyan, F Tinelli, F Frijia, S Crespi, F De Masi, D Montanaro, M C Morrone
In adults, partial damage to V1 or optic radiations abolishes perception in the corresponding part of the visual field, causing a scotoma. However, it is widely accepted that the developing cortex has superior capacities to reorganize following an early lesion to endorse adaptive plasticity. Here we report a single patient case (G.S.) with near normal central field vision despite a massive unilateral lesion to the optic radiations acquired early in life. The patient underwent surgical removal of a right hemisphere parieto-temporal-occipital atypical choroid plexus papilloma of the right lateral ventricle at four months of age, which presumably altered the visual pathways during in utero development...
October 31, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/29100836/changes-in-tricuspid-annular-geometry-in-patients-with-functional-tricuspid-regurgitation
#15
Ting Hai, Yannis Amador, Feroze Mahmood, Jelliffe Jeganathan, Arash Khamooshian, Ziyad O Knio, Robina Matyal, Alina Nicoara, David C Liu, Venkatachalam Senthilnathan, Kamal R Khabbaz
OBJECTIVE: To determine whether the indices of tricuspid annular dynamics that signify irreversible tricuspid valvular remodeling can improve surgical decision making by helping to better identify patients with functional tricuspid regurgitation who could benefit from annuloplasty. DESIGN: Retrospective analysis study. SETTING: Tertiary hospital. PARTICIPANTS: A total number of 55 patients were selected, 18 with functional tricuspid valve (TV) regurgitation and 37 normal nonregurgitant TVs...
June 20, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29100642/medium-term-outcomes-after-implantation-of-expanded-polytetrafluoroethylene-valved-conduit
#16
Yoshio Ootaki, Allison S Welch, Michael J Walsh, Michael D Quartermain, Derek A Williams, Ross M Ungerleider
BACKGROUND: Pulmonary valve replacement is becoming the most frequent congenital heart surgery performed on adolescents and young adults. Numerous surgical options are available, including autologous pericardium, mechanical valves, allografts, and bioprosthetic valves. Each option has limitations with durability and freedom from reintervention for stenosis or insufficiency, particularly in the pediatric population. The purpose of this study was to analyze our uniquely designed, expanded polytetrafluoroethylene (ePTFE) valved conduit (VC) for right ventricular outflow tract reconstruction...
November 1, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29098525/prognostic-value-of-real-time-three-dimensional-echocardiography-compared-to-two-dimensional-echocardiography-in-patients-with-systolic-heart-failure
#17
Frederico J N Mancuso, Valdir A Moises, Dirceu R Almeida, Dalva Poyares, Luciana J Storti, Flavio S Brito, Sergio Tufik, Angelo A V de Paola, Antonio C C Carvalho, Orlando Campos
Heart failure (HF) is associated with morbidity and mortality. Real-time three-dimensional echocardiography (RT3DE) may offer additional prognostic data in patients with HF. The study aimed to evaluate the prognostic value of real-time three-dimensional echocardiography (RT3DE). This is a prospective study that included 89 patients with HF and left ventricular ejection fraction (LVEF) < 0.50 who were followed for 48 months. Left atrium and ventricular volumes and functions were evaluated by RT3DE. TDI and two-dimensional echocardiography parameters were also obtained...
November 2, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29094480/myocardial-infarction-does-not-affect-circulating-hematopoietic-stem-and-progenitor-cell-self-renewal-ability-in-a-rat-model
#18
J M Kröpfl, C M Spengler, A Frobert, G Ajalbert, M N Giraud
Due to the importance of peripheral blood hematopoietic stem and progenitor cells (HPCs) in post-acute regeneration after acute myocardial infarction (MI), the present study aimed to investigate count and secondary replating capacity/self-renewal ability of HPCs in peripheral blood before and two weeks after MI. In nine female Lewis inbred rats (n = 9), myocardial infarction was induced by ligation of the left coronary artery while another nine had surgery without ligation for control purposes. Myocardial infarction was confirmed by troponin I concentrations 24 h after MI...
November 2, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/29094471/antifibrillatory-effects-of-renal-denervation-on-ventricular-fibrillation-in-a-canine-model-of-pacing-induced-heart-failure
#19
Qingzhi Luo, Qi Jin, Ning Zhang, Shangwei Huang, Yanxin Han, Changjian Lin, Tianyou Ling, Kang Chen, Wenqi Pan, Liqun Wu
This study investigated the effects of renal denervation (RDN) on vulnerability to ventricular fibrillation (VF) and ventricular electrical properties in a canine model of pacing-induced heart failure (HF). Eighteen beagles were divided into the following three groups: control (n = 6), HF (n = 6) and HF+RDN (n = 6). HF was induced by rapid right ventricular pacing. RDN was performed simultaneously with the pacemaker implantation in the HF+RDN group. A 64-unipolar basket catheter was used to perform global endocardial mapping of the left ventricle...
November 2, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/29091250/functional-hemispherectomy-for-adult-rasmussen-encephalitis-a-case-report-and-literature-review
#20
Qun Wang, Zhanpeng Zhu, Guangming Wang, Lichao Sun, Jiqing Qiu
BACKGROUND: Rasmussen encephalitis (RE) is a rare and severe brain disorder associated with unilateral hemispheric atrophy, manifesting as severe refractory epilepsy, hemiplegia, defects of motor and speech functions, and cognitive impairment. Treatment of RE, especially in adult patients, is extremely challenging. Herein, we report the case of an adult patient with RE who was treated with a functional hemispherectomy and achieved a favorable prognosis. CASE REPORT: A 29-year-old woman presented with a 24-year history of epileptic seizures...
September 26, 2017: Turkish Neurosurgery
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