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https://www.readbyqxmd.com/read/28913656/new-insights-into-cardiac-involvement-in-juvenile-scleroderma-a-three-dimensional-echocardiographic-assessment-unveils-subclinical-ventricle-dysfunction
#1
Reyhan Dedeoglu, Amra Adroviç, Funda Oztunç, Sezgin Sahin, Kenan Barut, Ozgur Kasapcopur
Cardiac manifestations in juvenile scleroderma or systemic sclerosis (JSSc) have poor prognosis, begin in early stages of the disease, and remain clinically asymptomatic. New echocardiography modalities, such as 2D/3D speckle tracking (STE, strain analysis for regional and global ventricular functions), can detect cardiac involvement in early stages. We assessed 21 JSSc patients and 19 controls using 2D/3D STE. The left ventricular end diastolic volume, end systolic volume, and ejection fraction of the patient and control groups were significantly different (99...
September 14, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28910586/global-and-regional-cardiac-function-in-lifelong-endurance-athletes-with-and-without-myocardial-fibrosis
#2
Thijs M H Eijsvogels, David L Oxborough, Rory O'Hanlon, Sanjay Sharma, Sanjay Prasad, Greg Whyte, Keith P George, Mathew G Wilson
The aim of the present study was to compare cardiac structure as well as global and regional cardiac function in athletes with and without myocardial fibrosis (MF). Cardiac magnetic resonance imaging with late gadolinium enhancement was used to detect MF and global cardiac structure in nine lifelong veteran endurance athletes (58 ± 5 years, 43 ± 5 years of training). Transthoracic echocardiography using tissue-Doppler and myocardial strain imaging assessed global and regional (18 segments) longitudinal left ventricular function...
September 14, 2017: European Journal of Sport Science
https://www.readbyqxmd.com/read/28910144/ask1-inhibition-halts-disease-progression-in-preclinical-models-of-pulmonary-arterial-hypertension
#3
Grant R Budas, Mario Boehm, Baktybek Kojonazarov, Gayathri Viswanathan, Xia Tian, Swathi Veeroju, Tatyana Novoyatleva, Friedrich Grimminger, Ford Hinojosa-Kirschenbaum, Hossein A Ghofrani, Norbert Weissmann, Werner Seeger, John T Liles, Ralph T Schermuly
RATIONALE Progression of pulmonary arterial hypertension (PAH) is associated with pathologic remodeling of the pulmonary vasculature and the right ventricle (RV). Oxidative stress drives the remodeling process through activation of mitogenactivated protein kinases (MAPKs) which stimulate apoptosis, inflammation and fibrosis. OBJECTIVES We investigated whether pharmacological inhibition of the redoxsensitive apical MAPK Apoptosis Signal-Regulating Kinase 1 (ASK1) can halt the progression of pulmonary vascular and RV remodeling...
September 14, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28905655/inverted-takotsubo-syndrome-in-androctonus-australis-scorpion-envenomation
#4
Fekri Abroug, Islem Ouanes, Mezri Maatouk, Mondher Golli, Lamia Ouanes-Besbes
CONTEXT: The nature of scorpion-related cardiomyopathy is still a matter of debate where specific toxin-induced cardiomyopathy, ischemic, or catecholaminergic cardiomyopathy is advocated as well. We report two cases of Takotsubo syndrome following envenomation by Androctonus australis, bringing new evidence for the fundamental role of catecholamines in the pathogenesis of this cardiomyopathy. Case 1: A woman aged 36 presented with pulmonary edema and shock following scorpion envenomation...
September 14, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28902381/-organ-interactions-heart-and-lung-management-of-the-acute-right-heart-failure
#5
Guido Michels, Roman Pfister
The pathophysiology and the management of patients with acute right heart failure are very complex. The bed-side focused echocardiography is the basis of differential diagnosis and acute diagnosis. Individual therapy monitoring is complex due to the strong preload dependence of the right ventricle and the limitation of non-invasive estimation of pulmonary-vascular hemodynamics, so that the indication for a pulmonary artery catheter should be liberal in acute right heart failure. The treatment goals of acute right heart failure are the treatment of the underlying disease or triggering factors in combination with individualized optimization of hemodynamic tailored to current right-ventricular function...
September 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28900614/echocardiographic-evaluation-of-pulmonary-pressures-and-right-ventricular-function-after-pediatric-cardiac-surgery-a-simple-approach-for-the-intensivist
#6
REVIEW
Maurice Beghetti
Pulmonary hypertension (PH) is diagnosed using cardiac catheterization and is defined as an elevation of mean pulmonary artery pressure (PAP) greater than 25 mmHg. Although invasive hemodynamics remains the gold standard and is mandatory for disease confirmation, transthoracic echocardiography (TTE) is an extremely useful non-invasive and widely available tool that allows for screening and follow-up, in particular, in the acute setting. TTE may be a valuable alternative, allowing for direct measurement and/or indirect assessment of PAP...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28899895/biomechanical-and-hemodynamic-measures-of-right-ventricular-diastolic-function-translating-tissue-biomechanics-to-clinical-relevance
#7
Sae Jang, Rebecca R Vanderpool, Reza Avazmohammadi, Eugene Lapshin, Timothy N Bachman, Michael Sacks, Marc A Simon
BACKGROUND: Right ventricular (RV) diastolic function has been associated with outcomes for patients with pulmonary hypertension; however, the relationship between biomechanics and hemodynamics in the right ventricle has not been studied. METHODS AND RESULTS: Rat models of RV pressure overload were obtained via pulmonary artery banding (PAB; control, n=7; PAB, n=5). At 3 weeks after banding, RV hemodynamics were measured using a conductance catheter. Biaxial mechanical properties of the RV free wall myocardium were obtained to extrapolate longitudinal and circumferential elastic modulus in low and high strain regions (E1 and E2, respectively)...
September 12, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28899642/evaluation-of-myocardial-function-according-to-early-diastolic-intraventricular-pressure-difference-in-fetuses
#8
Yuka Yamamoto, Ken Takahashi, Yo Takemoto, Maki Kobayashi, Keiichi Itatani, Toshiaki Shimizu, Atsuo Itakura, Satoru Takeda
BACKGROUND: Intraventricular pressure difference (IVPD), the diastolic suction during early diastole, is known as a useful marker of myocardial diastolic function in adults with different heart diseases, but there are no studies of fetal IVPD. The aim of this study was to determine whether IVPD exists and changes prenatally and whether IVPD correlates with preexisting parameters to evaluate fetal cardiac diastolic function and ventricular dominance. METHODS: Cross-sectional study data (stroke volume, fetal cardiac output, E/A ratio, and myocardial performance index) from 117 healthy fetuses at 17 to 36 weeks of gestation were retrospectively evaluated...
September 9, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28899472/-long-term-effect-of-oligodendrocyte-precursor-cell-transplantation-on-a-rat-model-of-white-matter-injury-in-the-preterm-infant
#9
Cheng-Jun Wu, Zhao-Yan Wang, Yin-Xiang Yang, Zuo Luan
OBJECTIVE: To investigate the long-term effect of oligodendrocyte precursor cell (OPC) transplantation on a rat model of white matter injury (WMI) in the preterm infant. METHODS: A total of 80 Sprague-Dawley rats aged 3 days were randomly divided into sham-operation group, model control group, 5-day ventricular/white matter transplantation group, 9-day ventricular/white matter transplantation group, 14-day ventricular/white matter transplantation group (n=10 each)...
September 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28898433/changes-in-parameters-of-right-ventricular-function-with-cardiac-resynchronization-therapy
#10
Abhishek Sharma, Carl J Lavie, Ajay Vallakati, Akash Garg, Sunny Goel, Jason Lazar, Gregg C Fonarow
BACKGROUND: Studies have shown that cardiac resynchronization therapy (CRT) significantly improves right ventricle (RV) size and function in patients with heart failure (HF). HYPOTHESIS: CRT does not lead to improvement in RV function independent of baseline clinical variables. METHODS: A systematic search of studies published between 1966 to August 31, 2015 was conducted using Pub Med, CINAHL, Cochrane CENTRAL and the Web of Science databases...
September 12, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28893266/myocardial-performance-index-in-female-athletes
#11
Zahraa Alsafi, Andreas Malmgren, Petri Gudmundsson, Martin Stagmo, Magnus Dencker
BACKGROUND: Long-term intensive training leads to morphological and mechanical changes in the heart generally known as "athlete's heart". Previous studies have suggested that the diastolic and systolic function of the ventricles is unaltered in athletes compared to sedentary. The purpose of this study was to investigate myocardial performance index (MPI) by pulsed wave Doppler (PWD) and by tissue Doppler imaging (TDI) in female elite athletes compared to sedentary controls. METHODS: The study consisted of 32 athletes (mean age 20 ± 2 years) and 34 sedentary controls (mean age 23 ± 2 years)...
September 11, 2017: Cardiovascular Ultrasound
https://www.readbyqxmd.com/read/28887060/ethnicity-in-pulmonary-arterial-hypertension-possibilities-for-novel-phenotypes-in-the-age-of-personalized-medicine
#12
Sarah K Medrek, Sandeep Sahay
In the last decade and a half, the introduction of new therapeutics has revolutionized the management of pulmonary arterial hypertension (PAH). These new treatment options have improved the quality of life and survival in PAH. With an armamentarium of options available, the identification of unique phenotypes can help practitioners choose tailored treatment regimens. Experts in other cardiovascular diseases such as congestive heart failure and hypertension have recommended race-specific treatments in their fields based on data highlighting variations in response to therapies...
September 5, 2017: Chest
https://www.readbyqxmd.com/read/28886927/suitability-of-cardiac-resynchronisation-therapy-in-patients-with-fontan-circulation-and-congenitally-corrected-transposition-of-the-great-arteries
#13
P Demetriades, A Bell, C Gubran, H Marshall, J de Bono, L Hudsmith
BACKGROUND: Cardiac resynchronisation therapy (CRT) is a well-recognised treatment in systolic heart failure. There is limited evidence in congenital patients with univentricular hearts or systemic right ventricles. In 2014 PACES/HRS published a consensus statement recommending CRT if ventricular ejection fraction (EF)≤35%, QRS duration≥150ms (with RBBB in systemic RV), NYHA II-IV and ventricular dilatation. The incidence of patients meeting these criteria in whom CRT is possible is not known...
September 2, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28884872/the-tip-of-the-muscle-is-a-dominant-location-of-ventricular-ectopy-originating-from-papillary-muscles-in-the-left-ventricle
#14
Petr Peichl, Jakub Baran, Dan Wichterle, Robert Čihák, Tomáš Skála, Bashar Aldhoon, Matevž Jan, Bor Antolič, Josef Kautzner
INTRODUCTION: Frequent ventricular premature complexes (VPCs) may cause symptoms and/or lead to deterioration of LV systolic function. Although frequent VPCs may be abolished by catheter ablation, it may be challenging in case of their origin from the LV papillary muscles (PMs). Our collaborative study aimed to analyze in detail the site of origin and the outcome of ablation. METHODS: Consecutive 34 patients (males: 68%; aged 62±12 years; LV ejection fraction: 50±9%) undergoing catheter ablation of VPCs originating from PMs were included...
September 8, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28884732/-the-rehabilitative-treatment-of-the-patients-presenting-with-chronic-obstructive-pulmonary-disease-including-the-application-of-the-manual-handling-methods
#15
N S Ayrapetova, M A Eremushkin, I V Antonovich, O F Kuznetsov, A E Samorukov, S P Budylin, L Yu Tarasova, N A Derevnina
AIM: The objective of the present study was to identify the peculiar features and advantages of different methods for the mechanical impact on the thoracic tissues of the patients presenting with chronic obstructive pulmonary disease (COPD) and to develop specific indications for their clinical applications. MATERIAL AND METHODS: This randomized prospective comparative study included 137 patients with COPD. In accordance with the currently accepted classification (GOLD, 2013), all the patients had COPD of medium severity...
2017: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/28878587/arrhythmogenic-right-ventricular-cardiomyopathy-in-an-endurance-athlete-presenting-with-ventricular-tachycardia-and-normal-right-ventricular-function
#16
Jeffrey S Hedley, Ibhar Al Mheid, Zoubin Alikhani, Maria A Pernetz, Jonathan H Kim
Arrhythmogenic right ventricular cardiomyopathy, a genetically inherited disease that results in fibrofatty replacement of normal cardiac myocytes, has been associated with sudden cardiac death in athletes. Long-term participation in endurance exercise hastens the development of both the arrhythmic and structural arrhythmogenic right ventricular cardiomyopathy phenotypes. We describe the unusual case of a 34-year-old, symptomatic, female endurance athlete who had arrhythmogenic right ventricular cardiomyopathy in the presence of a structurally normal right ventricle...
August 2017: Texas Heart Institute Journal
https://www.readbyqxmd.com/read/28878122/wnt11-regulates-cardiac-chamber-development-and-disease-during-perinatal-maturation
#17
Marlin Touma, Xuedong Kang, Fuying Gao, Yan Zhao, Ashley A Cass, Reshma Biniwale, Xinshu Xiao, Mansuoreh Eghbali, Giovanni Coppola, Brian Reemtsen, Yibin Wang
Ventricular chamber growth and development during perinatal circulatory transition is critical for functional adaptation of the heart. However, the chamber-specific programs of neonatal heart growth are poorly understood. We used integrated systems genomic and functional biology analyses of the perinatal chamber specific transcriptome and we identified Wnt11 as a prominent regulator of chamber-specific proliferation. Importantly, downregulation of Wnt11 expression was associated with cyanotic congenital heart defect (CHD) phenotypes and correlated with O2 saturation levels in hypoxemic infants with Tetralogy of Fallot (TOF)...
September 7, 2017: JCI Insight
https://www.readbyqxmd.com/read/28877887/another-step-in-the-right-direction-resynchronizing-the-dyssynchronous-right-ventricle-improves-its-efficiency-and-function
#18
EDITORIAL
Mark K Friedberg
No abstract text is available yet for this article.
September 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28874821/sprint-interval-training-decreases-left-ventricular-glucose-uptake-compared-to-moderate-intensity-continuous-training-in-subjects-with-type-2-diabetes-or-prediabetes
#19
Marja A Heiskanen, Tanja J Sjöros, Ilkka H A Heinonen, Eliisa Löyttyniemi, Mikko Koivumäki, Kumail K Motiani, Jari-Joonas Eskelinen, Kirsi A Virtanen, Juhani Knuuti, Jarna C Hannukainen, Kari K Kalliokoski
Type 2 diabetes mellitus (T2DM) is associated with reduced myocardial glucose uptake (GU) and increased free fatty acid uptake (FFAU). Sprint interval training (SIT) improves physical exercise capacity and metabolic biomarkers, but effects of SIT on cardiac function and energy substrate metabolism in diabetic subjects are unknown. We tested the hypothesis that SIT is more effective than moderate-intensity continuous training (MICT) on adaptations in left and right ventricle (LV and RV) glucose and fatty acid metabolism in diabetic subjects...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28870062/initial-clinical-and-hemodynamic-results-of-a-regional-pulmonary-thromboendarterectomy-program
#20
Farhan Raza, Anjali Vaidya, Anne-Sophie Lacharite-Roberge, Vladimir Lakhter, Hayan Al-Maluli, Irfan Ahsan, Pamela Boodram, Chandra Dass, Frances Rogers, Martin G Keane, Sheila Weaver, Riyaz Bashir, Yoshiya Toyoda, Paul Forfia
BACKGROUND: Pulmonary thromboendarterectomy (PTE) is the treatment of choice for eligible patients with chronic thromboembolic pulmonary hypertension (CTEPH). However, access to CTEPH and PTE care is limited. There is a paucity of published data on PTE efficacy and outcomes from alternative, regional centers of excellence in CTEPH and PTE care in the United States, outside a single national and international referral center. METHODS: We performed a retrospective review of patients undergoing PTE at our institution from June 2013 to December 2016 (42 months), and collected clinical, echocardiographic and hemodynamic data on our patients pre- and post-PTE (n=71)...
September 4, 2017: Journal of Cardiovascular Surgery
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