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https://www.readbyqxmd.com/read/28636480/the-emerging-role-of-pimavanserin-in-the-management-of-parkinson-s-disease-psychosis
#1
Neal Hermanowicz, Gustavo Alva, Fernando Pagan, Alberto J Espay, Amita Patel, Katya Cruz Madrid, Daniel Kremens, Jim Kenney, Sheila Arquette, Gary Tereso, Maria Lopes, Carolyn Farnum
A panel of experts drawn from neurology, psychiatry, geropsychiatry, geriatrics, and pharmacy representatives of 3 health plans convened in New York City on July 30, 2016, with the objective of sharing opinions, ideas, and information regarding the optimal management of Parkinson's disease psychosis (PDP). Three key points emerged from the discussion: (1) Because of the nature of Parkinson's disease and PDP, finding appropriate treatment can prove challenging; (2) emerging therapies may present an opportunity for effective disease management; and (3) moving forward, provider and patient education regarding PDP and available treatment options is essential for well-managed symptoms and better quality of life...
June 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28633654/physical-activity-and-associated-factors-from-a-cross-sectional-survey-among-adults-in-northern-tanzania
#2
Beatrice John, Jim Todd, Innocent Mboya, Mary Mosha, Mark Urassa, Tara Mtuy
BACKGROUND: Insufficient physical activity (PA) is a major contributing factor in the growing problem of non-communicable diseases (NCDs) in urban and rural Sub-Saharan Africa. This study aimed to determine PA and associated factors among adults in Northern Tanzania. METHODS: We analyzed secondary data from a cross-sectional serological survey nested within the Magu health and demographic sentinel surveillance population in Magu District Northwestern Tanzania. All resident adults aged 15 years and older were invited to participate in the study, and physical activity data were analyzed for 5663 participants...
June 20, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28631141/cell-labeling-with-magneto-endosymbionts-and-the-dissection-of-the-subcellular-location-fate-and-host-cell-interactions
#3
Kayla R Lee, Abdul Wakeel, Papia Chakraborty, Chandler S Foote, Lauren Kajiura, Joyce C Barrozo, Andrea C Chan, Alexey V Bazarov, Ryan Spitler, Peter M Kutny, Jim M Denegre, Rob A Taft, Joachim Seemann, Bradley W Rice, Christopher H Contag, Brian K Rutt, Caleb B Bell
PURPOSE: The purposes of this study are to characterize magneto-endosymbiont (ME) labeling of mammalian cells and to discern the subcellular fate of these living contrast agents. MEs are novel magnetic resonance imaging (MRI) contrast agents that are being used for cell tracking studies. Understanding the fate of MEs in host cells is valuable for designing in vivo cell tracking experiments. PROCEDURES: The ME's surface epitopes, contrast-producing paramagnetic magnetosomal iron, and genome were studied using immunocytochemistry (ICC), Fe and MRI contrast measurements, and quantitative polymerase chain reaction (qPCR), respectively...
June 19, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28628678/assessment-of-efficacy-and-irritation-of-ingenol-mebutate-gel-0-015-used-with-or-without-dimethicone-lotion-for-treatment-of-actinic-keratosis-on-the-face
#4
Shelbi C Jim On, Peter W Hashim, John K Nia, Mark G Lebwohl
<p>Background: Ingenol mebutate gel 0.015% provides high clearance rates for actinic keratosis (AK) on the face and scalp but causes transient local skin responses (LSRs).</p> <p>Objective: This study sought to determine whether the application of 1% dimethicone would decrease ingenol mebutate-associated LSRs and/or affect efficacy during the treatment of multiple AKs on the face.</p> <p>Methods: Ingenol mebutate gel 0.015% was applied for 3 days to two 25 cm2 areas, each containing 3 to 8 AKs on the face of each subject, followed by application of 1% dimethicone lotion in an investigator-blinded manner to one randomly selected AK-containing area until LSRs were no longer present...
May 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28627373/development-and-application-of-a-population-physiologically-based-pharmacokinetic-model-for-penicillin-g-in-swine-and-cattle-for-food-safety-assessment
#5
Miao Li, Ronette Gehring, Jim E Riviere, Zhoumeng Lin
Penicillin G is a widely used antimicrobial in food-producing animals, and one of the most predominant drug residues in animal-derived food products. Due to reduced sensitivity of bacteria to penicillin, extralabel use of penicillin G is common, which may lead to violative residues in edible tissues and cause adverse reactions in consumers. This study aimed to develop a physiologically based pharmacokinetic (PBPK) model to predict drug residues in edible tissues and estimate extended withdrawal intervals for penicillin G in swine and cattle...
June 13, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28627289/snap-n-send-a-valid-and-reliable-method-for-assessing-the-energy-intake-of-elite-adolescent-athletes
#6
Nessan Costello, Kevin Deighton, Joshua Dyson, Jim Mckenna, Ben Jones
To ensure that elite adolescent athletes meet their unique training, growth and maturation demands, it is imperative to have access to valid measures of energy intake. Contemporary methods demand close attention-to-detail, meaning that athletes often do not fully adhere to real-time protocols. This study represents the first investigation of a real-time dietary assessment designed using a comprehensive behaviour change framework (COM-B). In a crossover design, 12 elite adolescent male rugby players recorded their energy intake via an estimated food diary (est-FD) and photography-based mobile assessment ('Snap-n-Send'), combined with a 24-h dietary recall interview...
June 17, 2017: European Journal of Sport Science
https://www.readbyqxmd.com/read/28626829/socioeconomic-status-as-an-effect-modifier-of-alcohol-consumption-and-harm-analysis-of-linked-cohort-data
#7
Srinivasa Vittal Katikireddi, Elise Whitley, Jim Lewsey, Linsay Gray, Alastair H Leyland
BACKGROUND: Alcohol-related mortality and morbidity are high in socioeconomically disadvantaged populations compared with individuals from advantaged areas. It is unclear if this increased harm reflects differences in alcohol consumption between these socioeconomic groups, reverse causation (ie, downward social selection for high-risk drinkers), or a greater risk of harm in individuals of low socioeconomic status compared with those of higher status after similar consumption. We aimed to investigate whether the harmful effects of alcohol differ by socioeconomic status, accounting for alcohol consumption and other health-related factors...
June 2017: Lancet. Public Health
https://www.readbyqxmd.com/read/28625562/do-trauma-courses-change-practice-a-qualitative-review-of-20-courses-in-east-central-and-southern-africa
#8
Rele Ologunde, Grace Le, Jim Turner, Hemant Pandit, Noel Peter, David Maurer, Sam Hodgson, Joseph Larvin, Chris Lavy
BACKGROUND: Trauma courses have been shown to improve clinical knowledge and patient outcomes. However, little is known about the individual drivers of change in practice amongst course participants in their home clinic environment. METHODS: Front-line healthcare workers participated in a two-day Primary Trauma Care (PTC) course. Immediately after the course participants completed an evaluation survey on intended change in the management of trauma patients. Six months after the course, participants completed a survey on actual changes that had occurred...
June 13, 2017: Injury
https://www.readbyqxmd.com/read/28622455/intestinal-metabolites-are-profoundly-altered-in-the-context-of-hla-b27-expression-and-functionally-modulate-disease-in-a-rat-model-of-spondyloarthropathy
#9
Mark Asquith, Sean Davin, Patrick Stauffer, Claire Michell, Cathleen Janowitz, Phoebe Lin, Joe Ensign-Lewis, Jason M Kinchen, Dennis R Koop, Jim Rosenbaum
Objective HLA-B27 associated spondyloarthropathies are associated with an altered intestinal microbiota and bowel inflammation. Therefore, we sought to identify B27-dependent changes in both host and microbial metabolites in the HLA-B27/β2m rat and whether microbiota-derived metabolites could impact disease in this major model of spondyloarthropathy. Methods Cecal contents were collected from 6wk (pre-diseased) and 16wk (diseased) Fischer 344 HLA-B27/β2m transgenic rats and WT controls. Metabolomic profiling was performed by high-throughput gas- and liquid-chromatography-based mass spectrometry...
June 16, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28620572/unexpected-seed-migration-in-prostate-brachytherapy-implants-coincident-with-change-in-seed-stranding-product
#10
Jim Rose, Derek Liu, Oleksandr Boychak, Ron Sloboda, Nadeem Pervez, Albert Murtha, Don Yee, John Amanie, Nawaid Usmani
PURPOSE: This study was undertaken to determine if significant seed migration occurred when our institution changed seed products by comparing patterns of seed migration in implants containing different stranding material. METHODS AND MATERIALS: Day 0 and Day 30 CT scans were registered by the contoured prostate center of mass. An implant reconstruction program identified seeds on CT according to the pre-plan, enabling one-to-one correspondence between Day 0 and Day 30 seeds...
May 12, 2017: Curēus
https://www.readbyqxmd.com/read/28619940/rapid-cooling-and-cold-storage-in-a-silicic-magma-reservoir-recorded-in-individual-crystals
#11
Allison E Rubin, Kari M Cooper, Christy B Till, Adam J R Kent, Fidel Costa, Maitrayee Bose, Darren Gravley, Chad Deering, Jim Cole
Silicic volcanic eruptions pose considerable hazards, yet the processes leading to these eruptions remain poorly known. A missing link is knowledge of the thermal history of magma feeding such eruptions, which largely controls crystallinity and therefore eruptability. We have determined the thermal history of individual zircon crystals from an eruption of the Taupo Volcanic Zone, New Zealand. Results show that although zircons resided in the magmatic system for 10(3) to 10(5) years, they experienced temperatures >650° to 750°C for only years to centuries...
June 16, 2017: Science
https://www.readbyqxmd.com/read/28619938/kilogram-scale-prexasertib-monolactate-monohydrate-synthesis-under-continuous-flow-cgmp-conditions
#12
Kevin P Cole, Jennifer McClary Groh, Martin D Johnson, Christopher L Burcham, Bradley M Campbell, William D Diseroad, Michael R Heller, John R Howell, Neil J Kallman, Thomas M Koenig, Scott A May, Richard D Miller, David Mitchell, David P Myers, Steven S Myers, Joseph L Phillips, Christopher S Polster, Timothy D White, Jim Cashman, Declan Hurley, Robert Moylan, Paul Sheehan, Richard D Spencer, Kenneth Desmond, Paul Desmond, Olivia Gowran
Advances in drug potency and tailored therapeutics are promoting pharmaceutical manufacturing to transition from a traditional batch paradigm to more flexible continuous processing. Here we report the development of a multistep continuous-flow CGMP (current good manufacturing practices) process that produced 24 kilograms of prexasertib monolactate monohydrate suitable for use in human clinical trials. Eight continuous unit operations were conducted to produce the target at roughly 3 kilograms per day using small continuous reactors, extractors, evaporators, crystallizers, and filters in laboratory fume hoods...
June 16, 2017: Science
https://www.readbyqxmd.com/read/28619158/low-genetic-diversity-of-bovine-mycobacterium-avium-subspecies-paratuberculosis-isolates-detected-by-miru-vntr-genotyping
#13
Marcel de Kruijf, Olga N Lesniak, Dermot Yearsley, Elvira Ramovic, Aidan Coffey, Jim O'Mahony
Mycobacterial interspersed repetitive unit and variable number tandem repeat (MIRU-VNTR) has been developed as a simple, rapid and cost efficient molecular typing method to differentiate Mycobacterium avium subspecies paratuberculosis (MAP) isolates. The aim of this study was to determine the genomic diversity of MAP across the Republic of Ireland by utilising the MIRU-VNTR typing method on a large collection of MAP isolates. A total of 114 MAP isolates originated from 53 herds across 19 counties in the Republic of Ireland were genotyped based on eight established MIRU-VNTR loci...
May 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28619120/g6pd-deficiency-alleles-in-a-malaria-endemic-region-in-the-western-brazilian-amazon
#14
Jamille G Dombrowski, Rodrigo M Souza, Jonathan Curry, Laura Hinton, Natercia R M Silva, Lynn Grignard, Ligia A Gonçalves, Ana Rita Gomes, Sabrina Epiphanio, Chris Drakeley, Jim Huggett, Taane G Clark, Susana Campino, Claudio R F Marinho
BACKGROUND: Plasmodium vivax parasites are the predominant cause of malaria infections in the Brazilian Amazon. Infected individuals are treated with primaquine, which can induce haemolytic anaemia in glucose-6-phosphate dehydrogenase (G6PD)-deficient individuals and may lead to severe and fatal complications. This X-linked disorder is distributed globally and is caused by allelic variants with a geographical distribution that closely reflects populations exposed historically to endemic malaria...
June 15, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28618076/priorities-for-methodological-research-on-patient-and-public-involvement-in-clinical-trials-a-modified-delphi-process
#15
Anna Kearney, Paula Williamson, Bridget Young, Heather Bagley, Carrol Gamble, Simon Denegri, Delia Muir, Natalie A Simon, Stephen Thomas, Jim T Elliot, Helen Bulbeck, Joanna C Crocker, Claire Planner, Claire Vale, Mike Clarke, Tim Sprosen, Kerry Woolfall
BACKGROUND: Despite increasing international interest, there is a lack of evidence about the most efficient, effective and acceptable ways to implement patient and public involvement (PPI) in clinical trials. OBJECTIVE: To identify the priorities of UK PPI stakeholders for methodological research to help resolve uncertainties about PPI in clinical trials. DESIGN: A modified Delphi process including a two round online survey and a stakeholder consensus meeting...
June 15, 2017: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/28615217/reconsidering-current-objectives-for-physical-activity-within-physical-education
#16
EDITORIAL
Matthew Hobbs, Andrew Daly-Smith, Jim McKenna, Thomas Quarmby, David Morley
No abstract text is available yet for this article.
June 14, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28613978/increased-humoral-immunity-by-dna-vaccination-using-an-%C3%AE-tocopherol-based-adjuvant
#17
Ingrid Karlsson, Marie Borggren, Jens Nielsen, Dennis Christensen, Jim Williams, Anders Fomsgaard
DNA vaccines induce broad immunity, which involves both humoral and strong cellular immunity, and can be rapidly designed for novel or evolving pathogens such as influenza. However, the humoral immunogenicity in humans and higher animals has been suboptimal compared with that of traditional vaccine approaches. We tested whether the emulsion-based and α-tocopherol containing adjuvant Diluvac Forte® has the ability to enhance the immunogenicity of a naked DNA vaccine (i.e., plasmid DNA). As a model vaccine, we used plasmids encoding both a surface-exposed viral glycoprotein (hemagglutinin) and an internal non-glycosylated nucleoprotein in the Th1/Th2 balanced CB6F1 mouse model...
June 14, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28613817/neutron-reflection-study-of-surface-adsorption-of-fc-fab-and-the-whole-mab
#18
Zongyi Li, Ruiheng Li, Charles Smith, Fang Pan, Mario Campana, John Robert Peter Webster, Christopher F van der Walle, Shahid Uddin, Steven M Bishop, Jim Warwicker, Jian Ren Lu, Rojaramani Narwal
Characterizing the influence of Fc and Fab fragments on monoclonal antibody (mAb) adsorption at the air/water interface is an important step to understanding liquid mAb drug product stability during manufacture, shipping and storage. Here, neutron reflection is used to study the air/water adsorption of a mAb and its Fc and Fab fragments. By varying the isotopic contrast, the adsorbed amount, thickness, orientation and immersion of the adsorbed layers could be determined unambiguously. Whilst Fc adsorption reached saturation within the hour, its surface adsorbed amount showed little variation with bulk concentration...
June 14, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28610779/survival-and-complications-following-surgery-and-radiation-for-localized-prostate-cancer-an-international-collaborative-review
#19
REVIEW
Christopher J D Wallis, Adam Glaser, Jim C Hu, Hartwig Huland, Nathan Lawrentschuk, Daniel Moon, Declan G Murphy, Paul L Nguyen, Matthew J Resnick, Robert K Nam
BACKGROUND: Evaluation of treatment options for localized prostate cancer (PCa) remains among the highest priorities for comparative effectiveness research. Surgery and radiotherapy (RT) are the two interventions most commonly used. OBJECTIVE: To provide a critical narrative review of evidence of the comparative effectiveness and harms of surgery and RT in the treatment of localized PCa. EVIDENCE ACQUISITION: A collaborative critical narrative review of the literature was conducted...
June 10, 2017: European Urology
https://www.readbyqxmd.com/read/28610616/underutilisation-of-routinely-collected-data-in-the-hiv-programme-in-zambia-a-review-of-quantitatively-analysed-peer-reviewed-articles
#20
REVIEW
Tendai Munthali, Patrick Musonda, Paul Mee, Sehlulekile Gumede, Ab Schaap, Alwyn Mwinga, Caroline Phiri, Nathan Kapata, Charles Michelo, Jim Todd
BACKGROUND: The extent to which routinely collected HIV data from Zambia has been used in peer-reviewed published articles remains unexplored. This paper is an analysis of peer-reviewed articles that utilised routinely collected HIV data from Zambia within six programme areas from 2004 to 2014. METHODS: Articles on HIV, published in English, listed in the Directory of open access journals, African Journals Online, Google scholar, and PubMed were reviewed. Only articles from peer-reviewed journals, that utilised routinely collected data and included quantitative data analysis methods were included...
June 13, 2017: Health Research Policy and Systems
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