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https://www.readbyqxmd.com/read/29778922/interval-of-gonadotropin-administration-for-in-vitro-embryo-production-from-oocytes-collected-from-holstein-calves-between-2-and-6-months-of-age-by-repeated-laparoscopy
#1
Hernan Baldassarre, Luke Currin, Laura Michalovic, Anne-Marie Bellefleur, Karina Gutierrez, Rafael G Mondadori, Werner G Glanzner, Yasmin Schuermann, Rodrigo C Bohrer, Naomi Dicks, Rosalba Lopez, François-Xavier Grand, Christian Vigneault, Patrick Blondin, Jim Gourdon, Vilceu Bordignon
Laparoscopic Ovum Pick-Up (LOPU) in calves followed by in vitro embryo production (IVEP) and transfer (ET) into adult recipients has great potential for accelerated genetic gain through shortening of the generation interval. In this study, 11 Holstein calves were subjected to up to six LOPU procedures between the ages of 2-6 months at 2-3 weeks interval. In all cases, the animals received a CIDR 5 days prior to LOPU and were gonadotropin-stimulated starting at 72 h before LOPU using one of three protocols that were rotated twice among the animals during the study...
May 17, 2018: Theriogenology
https://www.readbyqxmd.com/read/29778017/the-preconception-care-experiences-of-women-with-epilepsy-on-sodium-valproate
#2
Lorna Lawther, Helen Dolk, Marlene Sinclair, Jim Morrow
PURPOSE: To understand the preconception experiences of women with epilepsy who have been taking the teratogenic drug valproate. METHODS: Seven women were recruited, three from a preconception clinic and four from an antenatal clinic in a region of the UK. All had taken valproate preconceptionally. Three preconception clinic encounters were observed and audio-recorded. Interviews with all women were analysed using Interpretative Phenomenological Analysis (IPA). RESULTS: Women experienced a "trajectory of balance"...
May 16, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29777331/sexual-expression-and-it-s-determinants-in-people-diagnosed-with-psychotic-disorders
#3
José de Jager, Roos van Greevenbroek, Annet Nugter, Jim van Os
This qualitative study aims to explore the difficulties people with a psychotic disorder have in sexual expression, and associated determinants. Twenty-eight semi-structured interviews were conducted and analyzed using the Grounded Theory method. Almost all participants experienced unfulfilled needs in sexual expression. These unfulfilled needs were associated with a range of factors, including antipsychotic medication, psychotic symptoms, sexual abuse, social skills and stigma, all of which may converge on a pathway involving (sexual) self-esteem...
May 18, 2018: Community Mental Health Journal
https://www.readbyqxmd.com/read/29775457/potassium-and-sodium-microdomains-in-thin-astroglial-processes-a-computational-model-study
#4
Kevin Breslin, John Joseph Wade, KongFatt Wong-Lin, Jim Harkin, Bronac Flanagan, Harm Van Zalinge, Steve Hall, Matthew Walker, Alexei Verkhratsky, Liam McDaid
A biophysical model that captures molecular homeostatic control of ions at the perisynaptic cradle (PsC) is of fundamental importance for understanding the interplay between astroglial and neuronal compartments. In this paper, we develop a multi-compartmental mathematical model which proposes a novel mechanism whereby the flow of cations in thin processes is restricted due to negatively charged membrane lipids which result in the formation of deep potential wells near the dipole heads. These wells restrict the flow of cations to "hopping" between adjacent wells as they transverse the process, and this surface retention of cations will be shown to give rise to the formation of potassium (K+) and sodium (Na+) microdomains at the PsC...
May 18, 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29774638/loss-of-sirtuin-1-and-mitofusin-2-contributes-to-enhanced-ischemia-reperfusion-injury-in-aged-livers
#5
Sung Kook Chun, Sooyeon Lee, Joseph Flores-Toro, Rebecca Y U, Ming-Jim Yang, Kristina L Go, Thomas G Biel, Catherine E Miney, Schiley Pierre Louis, Brian K Law, Mary E Law, Elizabeth M Thomas, Kevin E Behrns, Christiaan Leeuwenburgh, Jae-Sung Kim
Ischemia/reperfusion (I/R) injury is a causative factor contributing to morbidity and mortality during liver resection and transplantation. Livers from elderly patients have a poorer recovery from these surgeries, indicating reduced reparative capacity with aging. Mechanisms underlying this age-mediated hypersensitivity to I/R injury remain poorly understood. Here, we investigated how sirtuin 1 (SIRT1) and mitofusin 2 (MFN2) are affected by I/R in aged livers. Young (3 months) and old (23-26 months) male C57/BL6 mice were subjected to hepatic I/R in vivo...
May 17, 2018: Aging Cell
https://www.readbyqxmd.com/read/29773785/revealing-isoelectronic-size-conversion-dynamics-of-metal-nanoclusters-by-a-noncrystallization-approach
#6
Qiaofeng Yao, Victor Fung, Cheng Sun, Sida Huang, Tiankai Chen, De-En Jiang, Jim Yang Lee, Jianping Xie
Atom-by-atom engineering of nanomaterials requires atomic-level knowledge of the size evolution mechanism of nanoparticles, which remains one of the greatest mysteries in nanochemistry. Here we reveal atomic-level dynamics of size evolution reaction of molecular-like nanoparticles, i.e., nanoclusters (NCs) by delicate mass spectrometry (MS) analyses. The model size-conversion reaction is [Au23 (SR)16 ]- → [Au25 (SR)18 ]- (SR = thiolate ligand). We demonstrate that such isoelectronic (valence electron count is 8 in both NCs) size-conversion occurs by a surface-motif-exchange-induced symmetry-breaking core structure transformation mechanism, surfacing as a definitive reaction of [Au23 (SR)16 ]-  + 2 [Au2 (SR)3 ]- → [Au25 (SR)18 ]-  + 2 [Au(SR)2 ]- ...
May 17, 2018: Nature Communications
https://www.readbyqxmd.com/read/29771476/questioning-the-use-of-an-age-adjusted-d-dimer-threshold-to-exclude-venous-thromboembolism-reply
#7
S Takach Lapner, Jim A Julian, Lori-Ann Linkins, Shannon Bates, Clive Kearon
In a recent analysis[1], we questioned the validity of using a progressively higher D-dimer to define a positive test as the age of patients with suspected venous thromboembolism (VTE) increased over 50 years (termed "age-adjusted D-dimer" interpretation). We hypothesized that the benefits of age-adjusted D-dimer interpretation compared with using a conventional threshold of 500 ug/L in patients of all ages were due to a non-specific increase in the average D-dimer threshold used to classify a test as positive...
May 17, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29770136/cd3%C3%AE%C2%B5-expression-defines-functionally-distinct-subsets-of-v%C3%AE-1-t-cells-in-patients-with-human-immunodeficiency-virus-infection
#8
Pádraic J Dunne, Christina O Maher, Michael Freeley, Katie Dunne, Andreea Petrasca, Judy Orikiiriza, Margaret R Dunne, Derval Reidy, Siobhan O'Dea, Aisling Loy, Jim Woo, Aideen Long, Thomas R Rogers, Fiona Mulcahy, Derek G Doherty
Human γδ T cells expressing the Vδ1 T cell receptor (TCR) recognize self and microbial antigens and stress-inducible molecules in a major histocompatibility complex-unrestricted manner and are an important source of innate interleukin (IL)-17. Vδ1 T cells are expanded in the circulation and intestines of patients with human immunodeficiency virus (HIV) infection. In this study, we show that patients with HIV have elevated frequencies, but not absolute numbers, of circulating Vδ1 T cells compared to control subjects...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29769659/mannose-6-phosphate-receptor-a-novel-regulator-of-t-cell-immunity
#9
Anjuman Ara, Khawaja Ashfaque Ahmed, Jim Xiang
No abstract text is available yet for this article.
May 16, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29767569/teaching-tip-development-of-veterinary-anesthesia-simulations-for-pre-clinical-training-design-implementation-and-evaluation-based-on-student-perspectives
#10
Jana L Jones, Jim Rinehart, Jacqueline Jordan Spiegel, Ryane E Englar, Brian K Sidaway, Joie Rowles
Anesthesia simulations have been used in pre-clinical medical training for decades to help learners gain confidence and expertise in an operating room environment without danger to a live patient. The authors describe a veterinary anesthesia simulation environment (VASE) with anesthesia scenarios developed to provide a re-creation of a veterinarian's task environment while performing anesthesia. The VASE uses advanced computer technology with simulator inputs provided from standard monitoring equipment in common use during veterinary anesthesia and a commercial canine training mannequin that allows intubation, ventilation, and venous access...
2018: Journal of Veterinary Medical Education
https://www.readbyqxmd.com/read/29767088/interactive-effect-of-dietary-vitamin-e-and-inorganic-mercury-on-growth-performance-and-bioaccumulation-of-mercury-in-juvenile-olive-flounder-paralichthys-olivaceus-treated-with-mercuric-chloride
#11
Mohammad Moniruzzaman, Jun-Ho Lee, Jin-Hyeok Lee, Seonghun Won, Jim H Damusaru, Sungchul C Bai
A 6-week feeding trial was carried out to evaluate the effects of dietary vitamin E (dl-α-tocopheryl acetate, TA) on growth and mercury (Hg) accumulation in juvenile olive flounder ( Paralichthys olivaceus ) treated with mercuric chloride (HgCl2 ). Vitamin E and HgCl2 were added to the semi-purified basal diet. Six semi-purified diets in a 2 × 3 factorial design were formulated to contain 2 levels of Hg (0 or 20 mg HgCl2 /kg diet) and 3 levels of vitamin E (0, 100, or 200 mg TA/kg diet). Experimental fish ( n  = 360, 9...
September 2017: Animal nutrition
https://www.readbyqxmd.com/read/29765375/functional-alleles-of-chicken-bg-genes-members-of-the-butyrophilin-gene-family-in-peripheral-t-cells
#12
Lei Chen, Michaela Fakiola, Karen Staines, Colin Butter, Jim Kaufman
γδ T cells recognize a wide variety of ligands in mammals, among them members of the butyrophilin (BTN) family. Nothing is known about γδ T cell ligands in chickens, despite there being many such cells in blood and lymphoid tissues, as well as in mucosal surfaces. The major histocompatibility complex (MHC) of chickens was discovered because of polymorphic BG genes, part of the BTN family. All but two BG genes are located in the BG region, oriented head-to-tail so that unequal crossing-over has led to copy number variation (CNV) as well as hybrid (chimeric) genes, making it difficult to identify true alleles...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29763869/exposure-of-dioxin-like-chemicals-in-participants-of-the-anniston-community-health-survey-follow-up
#13
Eric Yang, Marian Pavuk, Andreas Sjödin, Michael Lewin, Richard Jones, Jim Olson, Linda Birnbaum
The 2014 follow-up of the Anniston Community Health Survey (ACHS II) consisted of 338 surviving participants from the 2005-2007 baseline study (ACHS) who had previous polychlorinated biphenyl (PCB) measurements, were not pregnant, and were not institutionalized. Questionnaires and blood samples provided the demographic, personal history, and chemical concentration data of the Anniston residents. Approximately 51% of participants were African American, 72% were female, and the mean age was 63 years old. The objectives of this study were to provide an exposure assessment of dioxin-like chemicals in the ACHS II participants and compare the measurements with the general United States (U...
May 12, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29762451/modified-design-of-anterolateral-thigh-flap-for-total-pharyngolaryngectomy-reconstruction-a-single-center-experience
#14
Li-Yen Cheng, Cha-Chun Chen, Hwang-Chi Lin, Chu-Hsu Jeng, Shang-Hsi Lin, Wei-Nung Jim Chen, Yu-Hsien Lin, Sheng-Po Hao
BACKGROUND: Defects after total pharyngolaryngectomy for hypopharyngeal cancer often require reconstruction via free tissue transfer. Recently, anterolateral thigh (ALT) flap has become the gold standard in many centers because of its advantages with respect to versatility, minimal donor-site morbidity, good speech quality, and relatively low fistula and anastomotic leakage rates. Moreover, ALT allows 2 surgical teams to work simultaneously. However, the height of the parallelogram in the ALT design for neoesophagus reconstruction is usually set at a minimum of 9...
May 14, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29760897/bison-body-size-and-climate-change
#15
Jeff M Martin, Jim I Mead, Perry S Barboza
The relationship between body size and temperature of mammals is poorly resolved, especially for large keystone species such as bison ( Bison bison ). Bison are well represented in the fossil record across North America, which provides an opportunity to relate body size to climate within a species. We measured the length of a leg bone (calcaneal tuber, DstL) in 849 specimens from 60 localities that were dated by stratigraphy and 14 C decay. We estimated body mass ( M ) as M  = (DstL/11.49)3 . Average annual temperature was estimated from δ18 O values in the ice cores from Greenland...
May 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29758994/structural-and-functional-connectivity-underlying-grey-matter-covariance-impact-of-developmental-insult
#16
Casey Paquola, Maxwell Bennett, Jim Lagopoulos
Structural covariance networks (SCNs) may offer unique insights into the developmental impact of childhood maltreatment because they are thought to reflect coordinated maturation of distinct grey matter regions. T1-weighted magnetic resonance images were acquired from 121 young people with emerging mental illness. Diffusion weighted and resting state functional imaging was also acquired from a random subset of the participants (n=62). Ten study-specific SCNs were identified using a whole brain grey matter independent component analysis...
May 15, 2018: Brain Connectivity
https://www.readbyqxmd.com/read/29757952/novel-n4-like-bacteriophages-of-pectobacterium-atrosepticum
#17
Colin Buttimer, Hanne Hendrix, Alan Lucid, Horst Neve, Jean-Paul Noben, Charles Franz, Jim O'Mahony, Rob Lavigne, Aidan Coffey
Pectobacterium atrosepticum is an economically important phytopathogen that is responsible for potato blackleg and soft rot, and for which current control strategies are limited. In this study, stem samples of potato crops exhibiting blackleg were taken from three farms in Co. Cork, Ireland, and they were found to be infected with P. atrosepticum . Three closely related bacteriophages (phages) that are specific to this phytopathogen were isolated and characterized, namely vB_PatP_CB1, vB_PatP_CB3, and vB_PatP_CB4 (abbreviated as CB1, CB3, and CB4)...
May 14, 2018: Pharmaceuticals
https://www.readbyqxmd.com/read/29757747/the-human-touch-practical-and-ethical-implications-of-putting-ai-and-robotics-to-work-for-patients
#18
Jim Banks
We live in a time when science fiction can quickly become science fact. Within a generation, the Internet has matured from a technological marvel to a utility, and mobile telephones have redefined how we communicate. Health care, as an industry, is quick to embrace technology, so it is no surprise that the application of programmable robotic systems that can carry out actions automatically and artificial intelligence (AI), e.g., machines that learn, solve problems, and respond to their environment, is being keenly explored...
May 2018: IEEE Pulse
https://www.readbyqxmd.com/read/29757489/emergency-department-discharge-of-pulmonary-embolus-patients
#19
W Frank Peacock, Craig I Coleman, Deborah Diercks, Samuel Francis, Christopher Kabrhel, Catherine Keay, Jeffery Kline, Jacob Manteuffel, Peter Wildgoose, Jim Xiang, Adam J Singer
BACKGROUND: Hospitalization for low risk pulmonary embolism (PE) is common, expensive, and of questionable benefit. OBJECTIVE: Determine if low-risk PE patients discharged from the emergency department (ED) on rivaroxaban require fewer hospital days compared to standard of care (SOC). METHODS: Multicenter, open label randomized trial in low risk PE defined by Hestia criteria. Adult subjects were randomized to early ED discharge on rivaroxaban, or SOC...
May 14, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29756668/amelioration-of-escherichia-coli-induced-endometritis-with-ascorbic-acid-in-non-pregnant-mouse-models
#20
Enitome Evi Bafor, Ikechukwu Onwukpa, Anne Oghenekevwe Itemire, Osemelomen Omoruyi, Ejiroghene Eferoba-Idio, Kevin Odega, Osas Jim Eghianruwa
PROBLEM: Infection-induced endometritis is associated with infertility. The outcome with oral antibiotics remains poor. This study therefore investigates the role of ascorbic acid in resolving endometritis. METHOD OF STUDY: Animals with established oestrus cycles were inoculated with Escherichia coli. Two days post-inoculation, the animals were administered ascorbic acid (10, 100 and 1000 mg/kg) and amoxicillin (500 mg/kg) for 5 days. Other groups included water only and E...
May 14, 2018: American Journal of Reproductive Immunology: AJRI
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