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https://www.readbyqxmd.com/read/28430282/a-ratiometric-sensor-for-dna-based-on-a-dual-emission-ru-dppz-light-switch-complex
#1
Michael G Walker, Vadde Ramu, Anthony J H M Meijer, Amitava Das, Jim A Thomas
Herein we describe the DNA binding properties of two new water-soluble ruthenium complexes; experimental and computational data reveal that both complexes display dual emission from MLCT and LLCT excited states. The interaction of the new complexes with DNA was also investigated. Although one of the complexes only binds DNA though groove binding, the second complex has separate ligands capable of groove binding and intercalation. Nevertheless, it was found that both complexes interact with duplex DNA with high affinity...
April 21, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28430029/legal-mapping-analysis-of-state-telehealth-reimbursement-policies
#2
Kate E Trout, Sankeerth Rampa, Fernando A Wilson, Jim P Stimpson
BACKGROUND: There exists rapid growth and inconsistency in the telehealth policy environment, which makes it difficult to quantitatively evaluate the impact of telehealth reimbursement and other policies without the availability of a legal mapping database. INTRODUCTION: We describe the creation of a legal mapping database of state-level policies related to telehealth reimbursement of healthcare services. Trends and characteristics of these policies are presented...
April 21, 2017: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/28428548/antiviral-activities-of-schizonepeta-tenuifolia-briq-against-enterovirus-71-in-vitro-and-in-vivo
#3
Sin-Guang Chen, Mei-Ling Cheng, Kuan-Hsing Chen, Jim-Tong Horng, Ching-Chuan Liu, Shih-Min Wang, Hiroaki Sakurai, Yann-Lii Leu, Shulhn-Der Wang, Hung-Yao Ho
No effective drug is currently available for treatment of enterovirus 71 (EV71) infection. Schizonepeta tenuifolia Briq. (ST) has been used as a herbal constituent of traditional Chinese medicine. We studied whether the aqueous extract of Schizonepeta tenuifolia Briq (STE) has antiviral activity. STE inhibited replication of EV71, as evident by its ability to diminish plaque formation and cytopathic effect induced by EV71, and to inhibit the synthesis of viral RNA and protein. Moreover, daily single-dose STE treatment significantly improved the survival of EV71-infected mice, and ameliorated the symptoms...
April 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28427462/within-person-associations-of-young-adolescents-physical-activity-across-five-primary-locations-is-there-evidence-of-cross-location-compensation
#4
Jordan A Carlson, Tarrah B Mitchell, Brian E Saelens, Vincent S Staggs, Jacqueline Kerr, Lawrence D Frank, Jasper Schipperijn, Terry L Conway, Karen Glanz, Jim E Chapman, Kelli L Cain, James F Sallis
BACKGROUND: Youth are active in multiple locations, but it is unknown whether more physical activity in one location is associated with less in other locations. This cross-sectional study examines whether on days with more physical activity in a given location, relative to their typical activity in that location, youth had less activity in other locations (i.e., within-person associations/compensation). METHODS: Participants were 528 adolescents, ages 12 to 16 (M = 14...
April 20, 2017: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/28427337/treatment-seeking-behaviour-in-low-and-middle-income-countries-estimated-using-a-bayesian-model
#5
Victor A Alegana, Jim Wright, Carla Pezzulo, Andrew J Tatem, Peter M Atkinson
BACKGROUND: Seeking treatment in formal healthcare for uncomplicated infections is vital to combating disease in low- and middle-income countries (LMICs). Healthcare treatment-seeking behaviour varies within and between communities and is modified by socio-economic, demographic, and physical factors. As a result, it remains a challenge to quantify healthcare treatment-seeking behaviour using a metric that is comparable across communities. Here, we present an application for transforming individual categorical responses (actions related to fever) to a continuous probabilistic estimate of fever treatment for one country in Sub-Saharan Africa (SSA)...
April 20, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/28421643/empiric-antibiotic-regimens-for-neonatal-sepsis-in-australian-and-new-zealand-neonatal-intensive-care-units
#6
Jeremy P Carr, David P Burgner, Rohan S Hardikar, Jim P Buttery
AIM: Neonatal sepsis remains an important cause of morbidity and mortality, and requires prompt empiric treatment. However, only a minority of babies who receive antibiotics for suspected sepsis have an infection. Antimicrobial exposure in infancy has important short- and long-term consequences. There is no consensus regarding empirical antimicrobial regimens. METHODS: The study included a survey of empiric antimicrobial regimens in all tertiary neonatal intensive care units in Australia and New Zealand in 2013-2014...
April 19, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/28420299/surface-chemistry-of-gold-nanoparticles-determines-the-biocorona-composition-impacting-cellular-uptake-toxicity-and-gene-expression-profiles-in-human-endothelial-cells
#7
Parwathy Chandran, Jim E Riviere, Nancy A Monteiro-Riviere
This study investigated the role of nanoparticle size and surface chemistry on biocorona composition and its effect on uptake, toxicity and cellular responses in human umbilical vein endothelial cells (HUVEC), employing 40 and 80 nm gold nanoparticles (AuNP) with branched polyethyleneimine (BPEI), lipoic acid (LA) and polyethylene glycol (PEG) coatings. Proteomic analysis identified 59 hard corona proteins among the various AuNP, revealing largely surface chemistry-dependent signature adsorbomes exhibiting human serum albumin (HSA) abundance...
April 19, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28419000/exercise-induced-autophagy-in-fatty-liver-disease
#8
Sung Kook Chun, Sooyeon Lee, Ming-Jim Yang, Christiaan Leeuwenburgh, Jae-Sung Kim
Hepatic steatosis prevails each year. Autophagy is integral in mitochondrial quality control and lipid homeostasis in the liver. No pharmacological strategies are currently available to reduce hepatic steatosis, but exercise has been known to improve clinical outcomes of chronic liver disease, particularly non-alcoholic fatty liver disease (NAFLD). Recent studies suggest that exercise may improve NAFLD through enhancing autophagy.
April 17, 2017: Exercise and Sport Sciences Reviews
https://www.readbyqxmd.com/read/28418861/brain-derived-neurotrophic-factor-involved-epigenetic-repression-of-ugt2b7-in-colorectal-carcinoma-a-mechanism-to-alter-morphine-glucuronidation-in-tumor
#9
Zi-Zhao Yang, Li Li, Ming-Cheng Xu, Hai-Xing Ju, Miao Hao, Jing-Kai Gu, Zai-Jie Jim Wang, Hui-Di Jiang, Lu-Shan Yu, Su Zeng
Uridine diphosphate-glucuronosyltransferase (UGT) 2B7, as one of significant drug enzymes, is responsible on the glucuronidation of abundant endobiotics or xenobiotics. We here report that it is markedly repressed in the tumor tissues of colorectal carcinoma (CRC) patients. Accordingly, morphine in CRC cells will stimulate the expression of its main metabolic enzyme, UGT2B7 during tolerance generation by activating the positive signals in histone 3, especially for trimethylated lysine 27 (H3K4Me3) and acetylated lysine 4 (H3K27Ac)...
March 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28417320/patient-reporting-in-the-eu-analysis-of-eudravigilance-data
#10
Marin Banovac, Gianmario Candore, Jim Slattery, Francois Houÿez, David Haerry, Georgy Genov, Peter Arlett
INTRODUCTION: New pharmacovigilance legislation was adopted in the EU in 2010 and became operational in July 2012. The legislation placed an obligation on all national competent authorities (NCAs) and marketing authorisation holders (MAHs) to record and report cases of suspected adverse drug reactions (ADRs) received from patients. OBJECTIVES: This descriptive study aims to provide insight into patient reporting for the totality of the EU by querying the EudraVigilance (EV) database for the period of 3 years before the new pharmacovigilance legislation became operational and the 3 years after as well as comparing patient reports with those from healthcare professionals (HCPs) where feasible...
April 17, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/28416132/discovery-of-indazole-aldosterone-synthase-cyp11b2-inhibitors-as-potential-treatments-for-hypertension
#11
Scott B Hoyt, Jerry Taylor, Clare London, Amjad Ali, Feroze Ujjainwalla, Jim Tata, Mary Struthers, Doris Cully, Tom Wisniewski, Ning Ren, Charlene Bopp, Andrea Sok, Andreas Verras, Daniel McMasters, Qing Chen, Elaine Tung, Wei Tang, Gino Salituro, Joe Clemas, Gaochao Zhou, Douglas MacNeil, Ruth Duffy, Yusheng Xiong
We report the discovery and hit-to-lead optimization of a structurally novel indazole series of CYP11B2 inhibitors. Benchmark compound 34 from this series displays potent inhibition of CYP11B2, high selectivity versus related steroidal and hepatic CYP targets, and lead-like physical and pharmacokinetic properties. On the basis of these and other data, the indazole series was progressed to lead optimization for further refinement.
April 8, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28416093/the-role-of-cognitive-functioning-in-the-relationship-between-childhood-trauma-and-a-mixed-phenotype-of-affective-anxious-psychotic-symptoms-in-psychotic-disorders
#12
Giovanni Mansueto, Martine van Nierop, Koen Schruers, Berhooz Z Alizadeh, Agna A Bartels-Velthuis, Nico J van Beveren, Richard Bruggeman, Wiepke Cahn, Lieuwe de Haan, Philippe Delespaul, Carin J Meijer, Inez Myin-Germeys, Rene S Kahn, Frederike Schirmbeck, Claudia J P Simons, Neeltje E M van Haren, Jim van Os, Ruud van Winkel
Cognitive impairments in patients with psychotic disorder have been associated with poor functioning and increased symptom severity. Furthermore, childhood trauma (CT) exposure has been associated with worse cognitive functioning as well as co-occurrence of affective-anxious-psychosis symptoms or a 'mixed phenotype of psychopathology' (MP), which in turn is associated with greater symptom severity, and poor functioning. This study aims to evaluate if cognition could be associated with CT/MP. 532 patients with non-affective psychotic patients were assessed on CT, symptom profile, cognition, functioning, and symptom severity at baseline and 3 and 6-year follow-up...
April 13, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28413336/a-restatement-of-the-natural-science-evidence-concerning-catchment-based-natural-flood-management-in-the-uk
#13
REVIEW
Simon J Dadson, Jim W Hall, Anna Murgatroyd, Mike Acreman, Paul Bates, Keith Beven, Louise Heathwaite, Joseph Holden, Ian P Holman, Stuart N Lane, Enda O'Connell, Edmund Penning-Rowsell, Nick Reynard, David Sear, Colin Thorne, Rob Wilby
Flooding is a very costly natural hazard in the UK and is expected to increase further under future climate change scenarios. Flood defences are commonly deployed to protect communities and property from flooding, but in recent years flood management policy has looked towards solutions that seek to mitigate flood risk at flood-prone sites through targeted interventions throughout the catchment, sometimes using techniques which involve working with natural processes. This paper describes a project to provide a succinct summary of the natural science evidence base concerning the effectiveness of catchment-based 'natural' flood management in the UK...
March 2017: Proceedings. Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28411963/using-a-knowledge-based-planning-solution-to-select-patients-for-proton-therapy
#14
Alexander R Delaney, Max Dahele, Jim P Tol, Ingrid T Kuijper, Ben J Slotman, Wilko F A R Verbakel
BACKGROUND AND PURPOSE: Patient selection for proton therapy by comparing proton/photon treatment plans is time-consuming and prone to bias. RapidPlan™, a knowledge-based-planning solution, uses plan-libraries to model and predict organ-at-risk (OAR) dose-volume-histograms (DVHs). We investigated whether RapidPlan, utilizing an algorithm based only on photon beam characteristics, could generate proton DVH-predictions and whether these could correctly identify patients for proton therapy...
April 12, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28406515/integration-of-community-structure-data-reveals-observable-effects-below-sediment-guideline-thresholds-in-a-large-estuary
#15
Louis A Tremblay, Dana Clark, Jim Sinner, Joanne I Ellis
The sustainable management of estuarine and coastal ecosystems requires robust frameworks due to the presence of multiple physical and chemical stressors. In this study, we assessed whether ecological health decline, based on community structure composition changes along a pollution gradient, occurred at levels below guideline threshold values for copper, zinc and lead. Canonical analysis of principal coordinates (CAP) was used to characterise benthic communities along a metal contamination gradient. The analysis revealed changes in benthic community distribution at levels below the individual guideline values for the three metals...
April 13, 2017: Environmental Science. Processes & Impacts
https://www.readbyqxmd.com/read/28404681/non-pnca-gene-mutated-but-pyrazinamide-resistant-m-tuberculosis-why-is-that
#16
Jim Werngren, Erik Alm, Mikael Mansjö
Pyrazinamide (PZA) is a key component for the effective treatment of drug susceptible and PZA-susceptible MDR (MDR(PZA-S)) tuberculosis. pncA gene mutations are usually detected in a clear majority (>90%) of the PZA resistant strains but obviously not in all. Rapid and reliable PZA DST is critical whenever PZA will be used in the regimen, not least for the treatment of MDR(PZA-S) TB. In this study, we selected 26 PZA resistant isolates reported to carry a wildtype pncA gene. To confirm resistance, susceptibility testing was repeated to 100 mg/L and 200 mg/L PZA for all the 26 isolates and Sanger sequencing was repeated on the 18 isolates that remained PZA resistant...
April 12, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28403125/low-vs-high-fidelity-the-importance-of-realism-in-the-simulation-of-a-stone-treatment-procedure
#17
Piyush Sarmah, Jim Voss, Adrian Ho, Domenico Veneziano, Bhaskar Somani
PURPOSE OF REVIEW: Simulation training for stone surgery is now increasingly used as part of training curricula worldwide. A combination of low and high fidelity simulators has been used with varying degrees of 'realism' provided by them. In this review, we discuss low and high fidelity simulators used for ureteroscopy (URS) and percutaneous nephrolithotomy (PCNL) stone procedures with their advantages, disadvantages and future direction for endourological simulation surgery. The final goal will be to understand whether or not 'realism' has to be considered as a critical element in simulation for this field...
April 11, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/28402627/strategy-for-the-quantitation-of-a-protein-conjugate-via-hybrid-immunocapture-liquid-chromatography-with-sequential-hrms-and-srm-based-lc-ms-ms-analyses
#18
Yue Zhao, Guowen Liu, Xiling Yuan, Jinping Gan, Jon E Peterson, Jim X Shen
With the development of modern instrumentation and technologies, mass spectrometry based assays have played an important role in protein bioanalysis. We have developed a novel strategy by combining the "bottom-up" and "top-down" approaches using both high-resolution (HRMS) and selected reaction monitoring (SRM) based mass spectrometric detection to quantify a positron emission tomography (PET) detection tracer for an oncology marker. Monkey plasma samples were processed by immunocapture purification, followed by liquid chromatography (LC) with HRMS full scan analysis...
April 21, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28402537/performance-assessment-and-translation-of-physiologically-based-pharmacokinetic-models-from-acslx%C3%A2-to-berkeley-madonna%C3%A2-matlab%C3%A2-and-r-language-oxytetracycline-and-gold-nanoparticles-as-case-examples
#19
Zhoumeng Lin, Majid Jaberi-Douraki, Chunla He, Shiqiang Jin, Raymond S H Yang, Jeffrey W Fisher, Jim E Riviere
Many physiologically based pharmacokinetic (PBPK) models for environmental chemicals, drugs, and nanomaterials have been developed to aid risk and safety assessments using acslXTM. However, acslXTM has been rendered sunset since November 2015. Alternative modeling tools and tutorials are needed for future PBPK applications. This forum article aimed to: (1) demonstrate the performance of four PBPK modeling software packages (acslXTM, Berkeley MadonnaTM, MATLAB®, and R language) tested using two existing models (oxytetracycline and gold nanoparticles); (2) provide a tutorial of PBPK model code conversion from acslXTM to Berkeley MadonnaTM, MATLAB®, and R language; (3) discuss the advantages and disadvantages of each software package in the implementation of PBPK models in toxicology, and (4) share our perspective about future direction in this field...
April 8, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28402450/sudden-cardiac-death-in-adults-with-congenital-heart-disease-does-qrs-complex-fragmentation-discriminate-in-structurally-abnormal-hearts
#20
Jim T Vehmeijer, Zeliha Koyak, Jouke P Bokma, Werner Budts, Louise Harris, Barbara J M Mulder, Joris R de Groot
Aims: Sudden cardiac death (SCD) causes a large portion of all mortality in adult congenital heart disease (ACHD) patients. However, identification of high-risk patients remains challenging. Fragmented QRS-complexes (fQRS) are a marker for SCD in patients with acquired heart disease but data in ACHD patients are lacking. We therefore aim to evaluate the prognostic value of fQRS for SCD in ACHD patients. Methods and results: From a multicentre cohort of 25 790 ACHD patients, we included tachyarrhythmic SCD cases (n = 147), and controls (n = 266) matched by age, gender, congenital defect and (surgical) intervention...
April 10, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
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