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https://www.readbyqxmd.com/read/27906189/distinct-outcomes-of-crl-nedd8-pathway-inhibition-reveal-cancer-cell-plasticity
#1
Anastasia V Rulina, Frédérique Mittler, Patricia Obeid, Sophie Gerbaud, Laurent Guyon, Eric Sulpice, Frédérique Kermarrec, Nicole Assard, Monika E Dolega, Xavier Gidrol, Maxim Y Balakirev
Inhibition of protein degradation by blocking Cullin-RING E3 ligases (CRLs) is a new approach in cancer therapy though of unknown risk because CRL inhibition may stabilize both oncoproteins and tumor suppressors. Probing CRLs in prostate cancer cells revealed a remarkable plasticity of cells with TMPRSS2-ERG translocation. CRL suppression by chemical inhibition or knockdown of RING component RBX1 led to reversible G0/G1 cell cycle arrest that prevented cell apoptosis. Conversely, complete blocking of CRLs at a higher inhibitor dose-induced cytotoxicity that was amplified by knockdown of CRL regulator Cand1...
December 1, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27904023/early-embryonic-development-of-long-tendons-in-the-human-foot
#2
Masahito Yamamoto, Yasuhiro Shiraishi, Kei Kitamura, Zhe Wu Jin, Gen Murakami, Jose Francisco Rodríguez-Vázquez, Shin-Ichi Abe
To examine a common plantar tendinous plate for long flexors of the toe and fingers in human embryos, we observed sections of 10 embryos at 5-6 weeks (crown-rump length or CRL 15-21 mm). The heel or tuber of the calcaneus was underdeveloped in 3 embryos with CRL 15 mm and the talus appeared not to be piled up on the calcaneus but these two bones were arranged along the lateromedial axis. As reported in the hand, we demonstrated, in the deep side of tarsal bones, a common tendinous plate formed by a joining of the flexor halluces longus and flexor digitorum longus tendons...
2016: Okajimas Folia Anatomica Japonica
https://www.readbyqxmd.com/read/27873546/evaluation-of-the-effect-of-soymilk-fermented-by-a-riboflavin-producing-lactobacillus-plantarum-strain-in-a-murine-model-of-colitis
#3
R Levit, G Savoy de Giori, A de Moreno de LeBlanc, J G LeBlanc
Inflammatory bowel diseases (IBD) are idiopathic diseases of the gastrointestinal tract characterised by recurrent inflammation that require lifelong treatments. It has been shown that certain strains of lactic acid bacteria (LAB) can produce specific health-promoting compounds in foods or in the gastrointestinal tract that can in turn prevent and/or treat IBD. This study was designed to evaluate the possible therapeutic potential of soymilk fermented by the riboflavin-producing strain Lactobacillus plantarum CRL 2130 in a trinitrobenzene sulfonic induced colitis mouse model...
November 22, 2016: Beneficial Microbes
https://www.readbyqxmd.com/read/27871201/first-trimester-reference-centiles-of-fetal-biometry-in-indian-population
#4
Manisha Kumar, Ravi Vajala, Karuna Sharma, Shalini Singh, Ritu Singh, Usha Gupta, J Bhattacharjee
AIMS AND OBJECTIVE: To create crown- rump length (CRL) based biometric chart for fetus in the first trimester among the Indian population. MATERIAL AND METHODS: Cross sectional data were obtained from 400 singleton pregnancies between 11 - 14 weeks gestation with a normal outcome. Linear regression models were constructed; the mean and standard deviation were derived as a function of CRL. RESULTS: There was a positive correlation of CRL with nuchal translucency (NT) (y = 0...
November 21, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27858960/lower-accuracy-in-prediction-of-delivery-date-in-stockholm-county-following-introduction-of-new-guidelines
#5
Hans Wessel, Tommy Nyberg
INTRODUCTION: In the Stockholm County new guidelines for predicting the day of delivery was introduced in 2010. Recent clinical use has indicated that the predictive quality might be suboptimal. This study compares the accuracy of three equations applied during the first (crown-rump length (CRL) or bi-parietal diameter (BPD)) and second trimesters (BPD or BPD combined with femur length (FL)). MATERIAL AND METHODS: In 14,239 ultrasound exams the accuracy of estimated delivery date was compared using median deviations from actual birth date, proportion of postterms, births within +/- 7 days of estimated delivery date, accuracy variations depending on fetal size, alternative fetal measurements obtained at the same occasion, and menstrual age...
November 17, 2016: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/27843708/prospective-preliminary-in-vitro-investigation-of-a-magnetic-iron-oxide-nanoparticle-conjugated-with-ligand-cd80-and-vegf-antibody-as-a-targeted-drug-delivery-system-for-the-induction-of-cell-death-in-rodent-osteosarcoma-cells
#6
AnneMarie Kay Kovach, Jen M Gambino, Vina Nguyen, Zach Nelson, Taylor Szasz, Jun Liao, Lakiesha Williams, Sandra Bulla, Raj Prabhu
Target drug deliveries using nanotechnology are a novel consideration in the treatment of cancer. We present herein an in vitro mouse model for the preliminary investigation of the efficacy of an iron oxide nanoparticle complex conjugated to vascular endothelial growth factor (VEGF) antibody and ligand cluster of differentiation 80 (CD80) for the purpose of eventual translational applications in the treatment of human osteosarcoma (OSA). The 35 nm diameter iron oxide magnetic nanoparticles are functionalized with an n-hydroxysuccinimide biocompatible coating and are conjugated on the surface to proteins VEGF antibody and ligand CD80...
2016: BioResearch Open Access
https://www.readbyqxmd.com/read/27834847/astaxanthin-and-docosahexaenoic-acid-reverse-the-toxicity-of-the-maxi-k-bk-channel-antagonist-mycotoxin-penitrem-a
#7
Amira A Goda, Khayria M Naguib, Magdy M Mohamed, Hassan A Amra, Somaia A Nada, Abdel-Rahman B Abdel-Ghaffar, Chris R Gissendanner, Khalid A El Sayed
Penitrem A (PA) is a food mycotoxin produced by several terrestrial and few marine Penicillium species. PA is a potent tremorgen through selective antagonism of the calcium-dependent potassium BK (Maxi-K) channels. Discovery of natural products that can prevent the toxic effects of PA is important for food safety. Astaxanthin (AST) is a marine natural xanthophyll carotenoid with documented antioxidant activity. Unlike other common antioxidants, AST can cross blood brain barriers (BBBs), inducing neuroprotective effects...
November 9, 2016: Marine Drugs
https://www.readbyqxmd.com/read/27833851/overexpression-of-cop9-signalosome-subunits-csn7a-and-csn7b-exerts-different-effects-on-adipogenic-differentiation
#8
Xiaohua Huang, Jürgen Ordemann, Johann Pratschke, Wolfgang Dubiel
The COP9 signalosome (CSN) is an essential regulator of cullin-RING-ubiquitin (Ub) ligases (CRLs), which ubiquitinate important cellular regulators and target them for degradation by the Ub proteasome system (UPS). The CSN exhibits deneddylating activity localized on subunit CSN5, which removes the ubiquitin-like protein Nedd8 from the cullins of CRLs. CSN-mediated deneddylation is an important step in the process of CRL remodeling, in which new substrate recognition units are incorporated into Ub ligases to meet changed requirements for proteolysis in cells...
November 2016: FEBS Open Bio
https://www.readbyqxmd.com/read/27818117/-induced-abortion-guidelines-for-clinical-practice%C3%A2-%C3%A2-text-of-the-guidelines-short-text
#9
C Vayssière, A Gaudineau, L Attali, K Bettahar, S Eyraud, P Faucher, P Fournet, D Hassoun, M Hatchuel, C Jamin, B Letombe, T Linet, M Msika Razon, A Ohanessian, H Segain, S Vigoureux, N Winer, S Wylomanski, A Agostini
OBJECTIVE: Develop recommendations for the practice of induced abortion. MATERIALS AND METHODS: The Pubmed database, the Cochrane Library and the recommendations from the French and foreign Gyn-Obs societies or colleges have been consulted. RESULTS: The number of induced abortions (IA) has been stable for several decades. There are a lot of factors explaining the choice of abortion when there is an unplanned pregnancy (UPP). Early initiation and choice of contraception in connection to the woman's life are associated with lower NSP...
November 3, 2016: Journal de Gynécologie, Obstétrique et Biologie de la Reproduction
https://www.readbyqxmd.com/read/27816740/relation-between-the-quality-of-the-ultrasound-image-acquisition-and-the-precision-of-the-measurement-of-the-crown-rump-length-in-the-late-first-trimester-what-are-the-consequences
#10
Ferdinand Dhombres, Nathalie Roux, Stéphanie Friszer, Roger Bessis, Babak Khoshnood, Jean-Marie Jouannic
OBJECTIVE: To assess the extent to which the distribution of crown-rump length (CRL) values may be correlated with different criteria for the quality of the CRL images. STUDY DESIGN: This is a retrospective analysis of a series of 977 CRL images, by two independent observers, for the presence or the absence of 14 quality hallmarks. Inter-observer agreement for the hallmarks was assessed by the proportion of agreement and Cohen's kappa. The association between the quantiles of the CRL distribution and the presence or absence of the 14 quality hallmarks was modeled using quantile regression...
October 27, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27816047/changes-in-hto-and-obt-activity-concentrations-in-the-perch-lake-aquatic-ecosystem
#11
S B Kim, F Farrow, M Bredlaw, M Stuart
Perch Lake, a small shallow shield lake located on the Chalk River Laboratories (CRL) site, contains elevated levels of tritium due to inputs from a nearby nuclear waste management area. The releases have been going on for many years but tritium levels in Perch Lake have been gradually decreasing since about year 2000. Lake water, sediments, aquatic plants, clams and fish were collected during the summer and fall of 2003 and 2013 at three locations in the lake. HTO activity concentrations were measured in all samples and OBT activity concentrations were measured in sediments, plants, clams and fish...
December 2016: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/27814980/-role-of-ultrasound-in-elective-abortions
#12
S Wylomanski, N Winer
Ultrasound plays a fundamental role in the management of elective abortions. Although it can improve the quality of post-abortion care, it must not be an obstacle to abortion access. We thus studied the role of ultrasound in pregnancy dating and possible alternatives and analyzed the literature to determine the role of ultrasound in post-abortion follow-up. During an ultrasound scan, the date of conception is estimated by measurement of the crown-rump length (CRL), defined by Robinson, or of the biparietal diameter (BPD), as defined by the French Center for Fetal Ultrasound (CFEF) after 11 weeks of gestation (Robinson and CFEF curves) (grade B)...
November 1, 2016: Journal de Gynécologie, Obstétrique et Biologie de la Reproduction
https://www.readbyqxmd.com/read/27796908/nanogold-gallate-chitosan-targeted-pulmonary-delivery-for-treatment-of-lung-cancer
#13
Seamkwan Komenek, Urarika Luesakul, Sanong Ekgasit, Tirayut Vilaivan, Narong Praphairaksit, Songchan Puthong, Nongnuj Muangsin
Lung cancer is one of the most of cancer type founds and a leading cause of death worldwide. Through the development of new candidate compound (3,4,5-tribenzyloxybenzoic acid (GAOBn)) and a drug delivery system of our design of quaternized chitosan-gallic acid-folic acid stabilized gold nanoparticles (Au@QCS-GA-FA) as the targeted nanocarrier for treatment of lung cancer, we have found that GAOBn not only showed high cytotoxicity against lung cancer cells (CHAGO) with more than tenfold than cisplatin, but also showed low toxicity against normal cells (CRL-1947)...
October 27, 2016: AAPS PharmSciTech
https://www.readbyqxmd.com/read/27790921/combined-repeated-dose-and-reproductive-developmental-toxicity-screening-test-of-1-tert-butoxy-4-chlorobenzene-in-rats
#14
Yasuhiro Tsubokura, Ryuichi Hasegawa, Sunao Aso, Toshio Kobayashi, Takayuki Koga, Satsuki Hoshuyama, Yutaka Oshima, Katsumi Miyata, Yuji Kusune, Takako Muroi, Naoki Hashizume, Yoshiyuki Inoue, Shozo Ajimi, Kotaro Furukawa
We have carried out animal toxicity tests of chemicals for a chemical safety program implemented by the Ministry of Economy, Trade, and Industry of Japan. Here, we tested 1-tert-butoxy-4-chlorobenzene in a combined repeat-dose and developmental and reproductive toxicity test. The test chemical was administered daily by gavage to 9-week-old Crl:CD (SD) rats at doses of 0, 20, 100, and 500  mg/kg/d. Males were treated for 42 d beginning 14 d before mating. Females were treated from 14 d before mating to day 4 of lactation...
October 28, 2016: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/27780005/effects-of-colored-enrichment-devices-on-circadian-metabolism-and-physiology-in-male-sprague-dawley-rats
#15
Melissa A Wren-Dail, Robert T Dauchy, Tara G Ooms, Kate C Baker, David E Blask, Steven M Hill, Lynell M Dupepe, Rudolf P Bohm
Environmental enrichment (EE) gives laboratory animals opportunities to engage in species-specific behaviors. However, the effects of EE devices on normal physiology and scientific outcomes must be evaluated. We hypothesized that the spectral transmittance (color) of light to which rats are exposed when inside colored enrichment devices (CED) affects the circadian rhythms of various plasma markers. Pair-housed male Crl:SD rats were maintained in ventilated racks under a 12:12-h light:dark environment (265.0 lx; lights on, 0600); room lighting intensity and schedule remained constant throughout the study...
2016: Comparative Medicine
https://www.readbyqxmd.com/read/27777190/-correlation-analysis-of-fetal-middle-cerebral-artery-peak-systolic-velocity-cardiothoracic-ratio-and-crown-rump-length-in-early-pregnancy
#16
Xu-Jie Deng, Cui-Hua Chen, Yu-Wen Qiu, Shu-Fang Xiao, Shu-Xin Liao, Mei Zhong, Fang Yang
OBJECTIVE: To explore the pattern of variations in middle cerebral artery peak systolic velocity (MCA PSV) and cardiothoracic ratio (CTR) during early pregnancy, establish their reference ranges and explore their correlation with the crown-rump length (CRL). METHODS: A total of 522 pregnant women with normal findings in antenatal examinations underwent routine color Doppler ultrasound examination to collect the data of MCA PSV, CTR and CRL. The reference ranges of MCA PSV and CTR for different CRL levels were established, and the correlation of MCA PSV and CTR with CRL was analyzed...
October 20, 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/27774986/targeted-inhibition-of-the-cop9-signalosome-for-treatment-of-cancer
#17
Anita Schlierf, Eva Altmann, Jean Quancard, Anne B Jefferson, René Assenberg, Martin Renatus, Matthew Jones, Ulrich Hassiepen, Michael Schaefer, Michael Kiffe, Andreas Weiss, Christian Wiesmann, Richard Sedrani, Jörg Eder, Bruno Martoglio
The COP9 signalosome (CSN) is a central component of the activation and remodelling cycle of cullin-RING E3 ubiquitin ligases (CRLs), the largest enzyme family of the ubiquitin-proteasome system in humans. CRLs are implicated in the regulation of numerous cellular processes, including cell cycle progression and apoptosis, and aberrant CRL activity is frequently associated with cancer. Remodelling of CRLs is initiated by CSN-catalysed cleavage of the ubiquitin-like activator NEDD8 from CRLs. Here we describe CSN5i-3, a potent, selective and orally available inhibitor of CSN5, the proteolytic subunit of CSN...
October 24, 2016: Nature Communications
https://www.readbyqxmd.com/read/27769295/a-home-calendar-and-recall-method-of-last-menstrual-period-for-estimating-gestational-age-in-rural-bangladesh-a-validation-study
#18
Alison D Gernand, Rina Rani Paul, Barkat Ullah, Muhammad A Taher, Frank R Witter, Lee Wu, Alain B Labrique, Keith P West, Parul Christian
BACKGROUND: The best method of gestational age assessment is by ultrasound in the first trimester; however, this method is impractical in large field trials in rural areas. Our objective was to assess the validity of gestational age estimated from prospectively collected date of last menstrual period (LMP) using crown-rump length (CRL) measured in early pregnancy by ultrasound. METHODS: As part of a large, cluster-randomized, controlled trial in rural Bangladesh, we collected dates of LMP by recall and as marked on a calendar every 5 weeks in women likely to become pregnant...
October 21, 2016: Journal of Health, Population, and Nutrition
https://www.readbyqxmd.com/read/27766995/the-outcome-of-monochorionic-diamniotic-twins-discordant-at-11-to-13-6-weeks-gestation
#19
Yaniv Zipori, Karen Reidy, T Gilchrist, Lex W Doyle, Mark P Umstad
BACKGROUND: Monochorionic diamniotic (MCDA) twin pregnancies are associated with adverse perinatal outcome. Intertwin discordances at the time of nuchal translucency (NT) screening may have a value in the prediction of fetal loss or twin-to-twin transfusion syndrome. We aimed to determine the ability of intertwin NT and crown rump length (CRL) discordances among MCDA twins to predict adverse outcomes. MATERIAL AND METHODS: All MCDA twins with a documented routine ultrasound at 11 to 13+6 weeks' gestation, and known pregnancy outcome between August 2003 and August 2012 were included...
December 2016: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://www.readbyqxmd.com/read/27740723/respiratory-syncytial-virus-hospitalization-and-mortality-systematic-review-and-meta-analysis
#20
Renato T Stein, Louis J Bont, Heather Zar, Fernando P Polack, Caroline Park, Ami Claxton, Gerald Borok, Yekaterina Butylkova, Colleen Wegzyn
BACKGROUND: Respiratory syncytial virus (RSV) is a major public health burden worldwide. We aimed to review the current literature on the incidence and mortality of severe RSV in children globally. METHODS: Systematic literature review and meta-analysis of published data from 2000 onwards, reporting on burden of acute respiratory infection (ARI) due to RSV in children. Main outcomes were hospitalization for severe RSV-ARI and death. RESULTS: Five thousand two hundred and seventy-four references were identified...
October 14, 2016: Pediatric Pulmonology
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