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https://www.readbyqxmd.com/read/28100706/oscul3a-negatively-regulates-cell-death-and-immunity-by-degrading-osnpr1-in-rice
#1
Qun-En Liu, Yuese Ning, Yingxin Zhang, Ning Yu, Chunde Zhao, Xiaodeng Zhan, Weixun Wu, Daibo Chen, Xiangjin Wei, Guo-Liang Wang, Shihua Cheng, Liyong Cao
Cullin3-based RING E3 ubiquitin ligases (CRL3), composed of Cullin3 (CUL3), RBX1, and BTB proteins, are involved in plant immunity but the function of CUL3 in the process is largely unknown. Here, we show that rice OsCUL3a is important for the regulation of cell death and immunity. The rice lesion mimic mutant oscul3a displays a significant increase in the accumulation of flg22- and chitin-induced reactive oxygen species, and in pathogenesis-related gene expression as well as resistance to Magnaporthe oryzae and Xanthomonas oryzae pv...
January 18, 2017: Plant Cell
https://www.readbyqxmd.com/read/28087919/presumptive-spontaneous-lysosomal-storage-like-disease-in-a-crl-cd1-icr-mouse
#2
Krista M
A clinically unremarkable 4.5-mo-old female Crl:CD1(ICR) VAF/Elite mouse was euthanized for scheduled sentinel processing.Gross necropsy findings included significant hepatosplenomegaly and visceral lymphadenomegaly, resulting in a preliminarygross diagnosis of lymphoma. Histology revealed florid accumulations of large, 'foamy' macrophages present in the bone marrow, small intestines, and viscera including liver, spleen, lymph nodes, thymus, uterus, and ovaries. The cytoplasm of these cells was abundant, stained pale blue with Wright-Giemsa and was periodic acid-Schiff positive...
January 13, 2017: Comparative Medicine
https://www.readbyqxmd.com/read/28078758/periconceptional-maternal-high-fish-and-olive-oil-low-meat-dietary-pattern-is-associated-with-increased-embryonic-growth-the-rotterdam-periconceptional-cohort-predict-study
#3
Francesca Parisi, Melek Rousian, Nicole A Huijgen, Anton H J Koning, Sten P Willemsen, Jeanne H M de Vries, Irene Cetin, Eric A P Steegers, Régine P M Steegers-Theunissen
OBJECTIVE: To investigate associations between periconceptional maternal dietary patterns and first trimester embryonic growth. METHODS: 228 women with singleton ongoing pregnancies were enrolled in a prospective periconceptional cohort study, comprising of 135 strictly dated spontaneous pregnancies and 93 pregnancies achieved after in vitro fertilization or intracytoplasmatic sperm injection (IVF/ICSI pregnancies). All women underwent longitudinal transvaginal three-dimensional ultrasound (3D-US) scans from 6(+0) up to 13(+0) weeks of gestation...
January 12, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28069173/periconceptional-maternal-biomarkers-of-one-carbon%C3%A2-metabolism-and-embryonic-growth-trajectories-the-rotterdam-periconceptional-cohort-predict-study
#4
Francesca Parisi, Melek Rousian, Anton H J Koning, Sten P Willemsen, Irene Cetin, Eric A P Steegers, Régine P M Steegers-Theunissen
OBJECTIVE: To study the associations between the periconceptional maternal biomarkers of one-carbon metabolism and embryonic growth. DESIGN: Prospective, periconceptional hospital-based birth cohort. SETTING: Tertiary medical care center. PATIENT(S): Between 2010 and 2014, 236 women with early singleton ongoing pregnancies that resulted in 139 strictly dated spontaneous pregnancies and 97 pregnancies conceived after assisted reproductive technology...
January 6, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28068893/differences-in-types-and-incidence-of-neoplasms-in-wistar-han-and-sprague-dawley-rats
#5
Klaus Weber
A substantial quantity of data on Sprague-Dawley (SD) and Hannover Wistar rats strains have been published concerning their source, diet, and housing conditions, as well as the incidences of nonneoplastic lesions and neoplasms observed in different laboratories. Differences between the commonly used rat strains provided by different breeders (i.e., CD (SD) vs. Harlan Sprague-Dawley strain or Crl: WI(Han) vs. Wistar Hannover (Han)-derived strain, continued breeding by RCC Ltd., Switzerland, thereafter continued breeding by Harlan) may include, but are not limited to, body weight, incidence, and onset of major nonneoplastic lesions and neoplasms, and these can impact the development of a nonclinical safety program...
January 2017: Toxicologic Pathology
https://www.readbyqxmd.com/read/28063263/three-dimensional-ultrasound-first-trimester-fetal-volume-measurement-and-its-relation-to-pregnancy-outcome
#6
Haitham A Torky, Asem A Moussa, Ali M Ahmad, Osama Dief, Manar A Eldesoouky, Ahmed S El-Gayed
AIM OF WORK: To determine whether fetal volume (FV) measured by three-dimensional (3D) ultrasound was able to detect fetuses at risk of low birth weight (primary outcome) and/or preterm labor (secondary outcome). METHODS: One hundred pregnant women carrying a singleton living pregnancy who were sure of dates, and had a dating scan, with gestational age between 11 weeks and 13 weeks+6 days coming for routine first trimester nuchal translucency (NT) were examined by both two-dimensional (2D) and 3D ultrasound (Vocal System) for crown-rump length (CRL) and FV then followed up regularly every 4 weeks until 28 weeks then biweekly until 36 weeks then weekly until delivery both clinically and by ultrasound biometry...
January 7, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28062907/prediction-of-fetal-loss-by-first-trimester-crown-rump-length-in-ivf-pregnancies
#7
Rinat Gabbay-Benziv, Amir Dolev, Ron Bardin, Israel Meizner, Benjamin Fisch, Avi Ben-Haroush
OBJECTIVE: To evaluate the association between small crown-rump length (CRL) and fetal loss ≤22 weeks in IVF pregnancies. METHODS: A retrospective analysis of prospectively collected data at a university-affiliated medical center. All singleton IVF pregnancies within a 5-year period, with a live embryo on first-trimester ultrasound and verified pregnancy outcome were included. Rates of fetal loss ≤22 weeks were compared between pregnancies with a CRL ≤tenth percentile and above the tenth percentile of our population...
January 7, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28060932/global-analysis-of-mannitol-2-dehydrogenase-in-lactobacillus-reuteri-crl-1101-during-mannitol-production-through-enzymatic-genetic-and-proteomic-approaches
#8
Maria Eugenia Ortiz, Juliana Bleckwedel, Silvina Fadda, Gianluca Picariello, Elvira M Hebert, Raúl R Raya, Fernanda Mozzi
Several plants, fungi, algae, and certain bacteria produce mannitol, a polyol derived from fructose. Mannitol has multiple industrial applications in the food, pharmaceutical, and medical industries, being mainly used as a non-metabolizable sweetener in foods. Many heterofermentative lactic acid bacteria synthesize mannitol when an alternative electron acceptor such as fructose is present in the medium. In previous work, we reported the ability of Lactobacillus reuteri CRL 1101 to efficiently produce mannitol from sugarcane molasses as carbon source at constant pH of 5...
2017: PloS One
https://www.readbyqxmd.com/read/28053879/lysozyme-association-with-circulating-rna-extracellular-vesicles-and-chronic-stress
#9
Sarah K Abey, Yuana Yuana, Paule V Joseph, Natnael D Kenea, Nicolaas H Fourie, LeeAnne B Sherwin, Gregory E Gonye, Paul A Smyser, Erin S Stempinski, Christina M Boulineaux, Kristen R Weaver, Christopher K E Bleck, Wendy A Henderson
BACKGROUND: Stress has demonstrated effects on inflammation though underlying cell-cell communication mechanisms remain unclear. We hypothesize that circulating RNAs and extracellular vesicles (EVs) in patients with chronic stress contain signals with functional roles in cell repair. METHODS: Blood transcriptome from patients with Irritable Bowel Syndrome versus controls were compared to identify signaling pathways and effectors. Plasma EVs were isolated (size-exclusion chromatography) and characterized for effectors' presence (immunogold labelling-electron microscopy)...
June 2017: BBA Clinical
https://www.readbyqxmd.com/read/28052594/network-meta-analysis-of-probiotics-to-prevent-respiratory-infections-in-children-and-adolescents
#10
REVIEW
Marina Azambuja Amaral, Gabriela Helena Barbosa Ferreira Guedes, Matias Epifanio, Mario Bernardes Wagner, Marcus Herbert Jones, Rita Mattiello
Probiotics have emerged as a promising intervention for the prevention of respiratory tract infections (RTIs) in children. Assess the effect of probiotics on prevention of RTIs in children and adolescents. MEDLINE, EMBASE, LILACS, SCIELO, CINAHL, SCOPUS, and Web of Science. Key words: "respiratory tract infections" AND probiotics. Randomized controlled trials RCT assessing the effect of probiotics on RTIs in children and adolescents were included. Two reviewers, working independently, to identify studies that met the eligibility criteria...
January 3, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28011597/exploring-the-methanogen-and-bacterial-communities-of-rumen-environments-solid-adherent-fluid-and-epimural
#11
Thijs De Mulder, Karen Goossens, Nico Peiren, Leen Vandaele, Annelies Haegeman, Caroline De Tender, Tom Ruttink, Tom Van de Wiele, Sam De Campeneere
The rumen microbiome occupies a central role in animal health and productivity. A better understanding of the rumen ecosystem is essential to increase productivity or decrease methane production. Samples were collected from the three main rumen environments: the solid adherent fraction, the liquid fraction and the epithelium. For the liquid and solid fraction, two alternative sample processing protocols were compared, resulting in a total of five sample types: crude solids (S), the eluted solid adherent fraction (Ad), free-living species in the crude rumen liquid (CRL), strained liquid samples (Lq) and epimural scrapings (Ep)...
December 22, 2016: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/28006080/crown-rump-length-audit-plots-with-the-use-of-operator-specific-papp-a-and-%C3%A3-hcg-median-mom
#12
Joan Sabria, Laura Guirado, Isabel Miró, Maria Dolors Gómez-Roig, Antoni Borrell
OBJECTIVE: Audit the crown-rump length (CRL) measurements taken at 11-13 weeks scan, using operator-specific median multiples of the median (MoM) for pregnancy-associated plasma protein-A (PAPP-A) and free ß-human chorionic gonadotropin (ß-hCG) plots, to identify deviations potentially related to a systematic CRL bias. METHODS: Study population included consecutive singleton pregnancies undergoing first trimester combined screening, scanned by sonologists with at least 100 scans, during the 2011-12 period...
December 22, 2016: Prenatal Diagnosis
https://www.readbyqxmd.com/read/28003042/epidemiology-of-hepatitis-b-infection-in-finland-implications-for-immunisation-policy
#13
Tanja Karvonen, Kari Auranen, Markku Kuusi, Tuija Leino
OBJECTIVES: We describe the current epidemiology of acute and chronic hepatitis B infections in Finland. We estimate the total incidence of chronic hepatitis B following from the current incidence of acute infections and the influx of chronic carriers of hepatitis B associated with net immigration. We evaluate the incidence of hepatitis B infections preventable by a universal vaccination programme among infants. METHODS: We analysed hepatitis B cases reported to the National Infectious Disease Register during 2004-2012 and used pre-developed methods to adjust for acute asymptomatic infections...
January 11, 2017: Vaccine
https://www.readbyqxmd.com/read/27988336/jsi-124-inhibits-ige-production-in-an-ige-b-cell-line
#14
Lulu Cui, Jiacheng Bi, Dehong Yan, Xiufeng Ye, Mingxing Zheng, Guang Yu, Xiaochun Wan
IgE is a key effector molecule in atopic diseases; however, the regulation mechanisms of IgE production in IgE B cells remain poorly understood. In the present study, we demonstrate that JSI-124 (cucurbitacin I), a selective STAT3 inhibitor, selectively inhibits production of IgE by a human IgE B cell line, CRL-8033 cells, while does not affect the IgG production by IgG B cell lines. In the aspect of molecular mechanism, we found that Igλ, but not Ighe, gene expression was suppressed by JSI-124. The above effects of JSI-124 were not mediated by affecting cellular proliferation or apoptosis...
December 14, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27966212/factors-stimulating-riboflavin-produced-by-lactobacillus-plantarum-crl-725-grown-in-a-semi-defined-medium
#15
Marianela Juarez Del Valle, Jonathan Emiliano Laiño, Graciela Savoy de Giori, Jean Guy LeBlanc
Riboflavin (vitamin B2 ) is one of the B-group water-soluble vitamins and is essential for energy metabolism of the cell. The aim of this study was to determine factors that affect riboflavin production by Lactobacillus (L.) plantarum CRL 725 grown in a semi defined medium and evaluate the expression of its rib genes. The factors found to enhance riboflavin production in this medium were incubation at 30 °C, and the addition of specific medium constituents, such as casamino acids (10 g L(-1) ), guanosine (0...
December 14, 2016: Journal of Basic Microbiology
https://www.readbyqxmd.com/read/27955654/depletion-of-sag-rbx2-e3-ubiquitin-ligase-suppresses-prostate-tumorigenesis-via-inactivation-of-the-pi3k-akt-mtor-axis
#16
Mingjia Tan, Jie Xu, Javed Siddiqui, Felix Feng, Yi Sun
BACKGROUND: SAG (Sensitive to Apoptosis Gene), also known as RBX2, ROC2 or RNF7, is a RING component of CRL (Cullin-RING ligase), required for its activity. Our recent study showed that SAG/RBX2 co-operated with Kras to promote lung tumorigenesis, but antagonized Kras to inhibit skin tumorigenesis, suggesting a tissue/context dependent function of Sag. However, it is totally unknown whether and how Sag would play in prostate tumorigenesis, triggered by Pten loss. METHODS: Sag and Pten double conditional knockout mice were generated and prostate specific deletion of Sag and Pten was achieved by PB4-Cre, and their effect on prostate tumorigenesis was evaluated by H&E staining...
December 12, 2016: Molecular Cancer
https://www.readbyqxmd.com/read/27940523/the-impact-of-child-restraint-legislation-on-the-incidence-of-severe-paediatric-injury-in-chile
#17
J Ignacio Nazif-Muñoz, Geneviève Gariépy, James Falconer, Annie Gong, Alison Macpherson
BACKGROUND: The objective of this study is to determine the association between Chile's 2005 child restraint legislation (CRL) and the incidence of severe paediatric motor vehicle-related injury. METHODS: We analysed motor vehicle injury data from Chile's Road Safety Commission from 2000 to 2012 to determine the association between Chile's 2005 CRL and severe paediatric injury. Using Poisson time-series models we assessed the effect of the law on two outcome variables: (1) severely injured children per vehicle fleet; and (2) severely injured children per population...
December 9, 2016: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
https://www.readbyqxmd.com/read/27931813/evaluation-of-the-in-vivo-mutagenicity-of-melamine-by-the-rbc-pig-a-assay-and-pigret-assay
#18
Takahiro Kyoya, Masami Hori, Megumi Terada
The Pig-a assay is a new in vivo genotoxicity test for detecting mutagens in the bodies of animals, using the endogenous Pig-a gene as the target. There are two types of Pig-a assays: the red blood cell (RBC) Pig-a assay, which uses RBCs, and the PIGRET assay, which uses reticulocytes. The Japanese Environmental Mutagen Society-Mammalian Mutagenicity Study Group collaborative study of the Pig-a assay was carried out to investigate the usefulness of the PIGRET assay. The mutagenicity of melamine was evaluated as part of this study...
November 15, 2016: Mutation Research
https://www.readbyqxmd.com/read/27931806/detection-of-pig-a-gene-mutants-in-rat-peripheral-blood-following-a-single-urethane-treatment-a-comparison-of-the-rbc-pig-a-and-pigret-assays
#19
Kazunori Narumi, Yohei Fujiishi, Emiko Okada, Wakako Ohyama
The rat red blood cell (RBC) Pig-a assay has been recommended by an expert working group of the International Workshop on Genotoxicity Testing as a potential new method to evaluate in vivo gene mutations in regulatory genotoxicity risk assessments. In a collaborative study in Japan, an improved Pig-a assay using reticulocytes (PIGRET assay) with magnetic enrichment of CD71-positive cells was evaluated, and it was revealed that this assay could detect the mutagenicity of chemicals earlier than the RBC Pig-a assay could...
November 15, 2016: Mutation Research
https://www.readbyqxmd.com/read/27931802/evaluation-of-in-vivo-mutagenicity-of-isopropyl-methanesulfonate-by-rbc-pig-a-and-pigret-assays
#20
Satoru Itoh, Chiharu Hattori, Shiho Nakayama, Akiharu Hanamoto
A comparison between the original red blood cell (RBC) Pig-a assay, which measures Pig-a mutant cells in RBCs, and the PIGRET assay, which uses reticulocytes, was conducted using the in vivo mutagenesis assay with isopropyl methanesulfonate (iPMS) as a part of a collaborative study by the Mammalian Mutagenicity Study Group in the Japanese Environmental Mutagen Society. Three dose levels of iPMS (50, 100, and 200mg/kg) were administered once intraperitoneally to 8-week-old male Crl:CD(SD) rats, and peripheral blood was sampled at 0 (1 day before dosing), and 1, 2, and 4 weeks after dosing with iPMS...
November 15, 2016: Mutation Research
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