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https://www.readbyqxmd.com/read/29032600/synthesis-and-characterization-of-the-hemi-salen-ligands-and-their-triboron-complexes-spectroscopy-and-examination-of-anticancer-properties
#1
Ahmet Kilic, Ismail Koyuncu, Mustafa Durgun, Ismail Ozaslan, İbrahim Halil Kaya, Ataman Gönel
The synthesis, spectroscopic properties and in vitro cytotoxicity activity of a series of various salen-based triboron complexes have been designed and prepared from hemi-salen (L1 H3 -L4 H3 ) ligands and BF3 .Et2 O or BPh3 under simple reaction conditions. The hemi-salen (L1 H3 -L4 H3 ) ligands and their BF2 or BPh2 chelating triboron complexes were characterized by means of NMR ((1) H, (13) C, (19) F and (11) B) spectra, FT-IR spectra, UV-Vis spectra, fluorescence spectra, mass spectra, melting point as well as elemental analysis...
October 15, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/29020779/management-of-medical-termination-of-pregnancy-mtop-up-until-the-7th-week-of-gestation-in-the-czech-republic
#2
P Slunska, J Hanacek, M Fanta, B Sehnal, R Gerychová, A Hola, A Zdenkova, H Neumannová, M Dziakova, M Lubusky
OBJECTIVE: In the Czech Republic (CR), it is possible, to carry out Medical Termination of Pregnancy (MToP) in the 1st trimester since June 2014, in case a woman submits a written request for it and in case the ultrasound examination confirms an intrauterine singleton prosperous pregnancy, between day 42 and 49 of gestation, crown-rump length (CRL) of the embryo 2-9 mm. The aim of the study is to analyze the management of MToP up until the 7th week of gestation in five centres in the CR...
2017: Ceská Gynekologie
https://www.readbyqxmd.com/read/29020778/-management-of-medical-termination-of-pregnancy-mtop-up-until-the-7th-week-of-gestation-in-the-czech-republic
#3
P Slunska, J Hanacek, M Fanta, B Sehnal, R Gerychová, A Hola, A Zdenkova, H Neumannová, M Dziakova, M Lubusky
OBJECTIVE: In the Czech Republic (CR), it is possible, to carry out Medical Termination of Pregnancy (MToP) in the 1st trimester since June 2014, in case a woman submits a written request for it and in case the ultrasound examination confirms an intrauterine singleton prosperous pregnancy, between day 42 and 49 of gestation, crown-rump length (CRL) of the embryo 2-9 mm. The aim of the study is to analyze the management of MToP up until the 7th week of gestation in five centres in the CR...
2017: Ceská Gynekologie
https://www.readbyqxmd.com/read/28968571/application-of-commercial-and-non-commercial-immobilized-lipases-for-biocatalytic-production-of-ethyl-lactate-in-organic-solvents
#4
Michalis Koutinas, Chrystalleni Yiangou, Natália M Osório, Katerina Ioannou, Albert Canet, Francisco Valero, Suzana Ferreira-Dias
This study explores the potential for enhancing the production of ethyl lactate (EL), a green solvent, through enzymatic esterification. Different solvents were compared as organic media for conversion of lactate and ethanol into EL, catalyzed by Novozym 435. Chloroform and hexane were the most effective in low acid concentrations (0.01-0.1M) exhibiting maximum EL yields of 88% and 75% respectively. The yield of EL improved as the solvent's LogP increased up to a value of 2. Non-commercial immobilized biocatalysts consisting heterologous Rhizopous oryzae (rROL) and Candida rugosa (CRL) lipases immobilized on hydrophobic supports were compared to commercial biocatalysts clarifying that Novozym 435 and Lipozyme RM IM could be efficiently applied...
September 20, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28956240/nisin-z-produced-by-lactococcus-lactis-from-bullfrog-hatchery-is-active-against-citrobacter-freundii-a-red-leg-syndrome-related-pathogen
#5
Gabriel Quintana, Maria V Niederle, Carlos J Minahk, Gianluca Picariello, María E F Nader-Macías, Sergio E Pasteris
Lactococcus lactis subsp. lactis CRL 1584 isolated from a bullfrog hatchery produces a bacteriocin that inhibits both indigenous Citrobacter freundii (a Red-Leg Syndrome related pathogen) and Lactobacillus plantarum, and Listeria monocytogenes as well. Considering that probiotics requires high cell densities and/or bacteriocin concentrations, the effect of the temperature on L. lactis growth and bacteriocin production was evaluated to find the optimal conditions. Thus, the growth rate was maximal at 36 °C, whereas the highest biomass and bacteriocin activity was achieved between 20 and 30 °C and 20-25 °C, respectively...
September 27, 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28950197/preparation-and-cytotoxicity-of-chitosan-based-hydrogels-modified-with-silver-nanoparticles
#6
Bożena Tyliszczak, Anna Drabczyk, Sonia Kudłacik-Kramarczyk, Katarzyna Bialik-Wąs, Regina Kijkowska, Agnieszka Sobczak-Kupiec
Chitosan based hydrogels are commonly applied in various fields of medicine and pharmacy. Modification of hydrogel polymers using nanosilver particles may result in formation of materials with enhanced antibacterial properties. In this article synthesis of hydrogel materials based on chitosan and modified with silver nanoparticles is presented. First, preparation and characterization of silver nanoparticles using UV-vis spectroscopy has been shown. Hydrogels modified with nanosilver particles were subjected to the measurements of swelling ability and in vitro tests in distilled water and Simulated Body Fluid (SBF), respectively...
September 20, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28927609/structure-and-properties-of-oil-palm-based-nanocellulose-reinforced-chitosan-nanocomposite-for-efficient-synthesis-of-butyl-butyrate
#7
Nursyafiqah Elias, Sheela Chandren, Nursyafreena Attan, Naji Arafat Mahat, Fazira Ilyana Abdul Razak, Joazaizulfazli Jamalis, Roswanira Abdul Wahab
In this study, nanocellulose (NC) was successfully extracted from oil palm frond leaves (OPFL) using a combination of bleaching, alkaline treatment and acid hydrolysis. X-ray diffractogram revealed the extracted NC was crystalline with a crystallinity index of 70.2%. This indicates its suitability as nano-fillers for preparing the chitosan/nanocellulose (CS-NC) supports to immobilize Candida rugosa lipase (CRL) to produce the CRL/CS-NC biocatalysts. FTIR, FESEM and TGA characterizations of the CRL/CS-NC confirm the CRLs were successfully conjugated to the CS-NC supports...
November 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28905714/cross-foster-rederivation-compared-with-antibiotic-administration-in-the-drinking-water-to-eradicate-bordetella-pseudohinzii
#8
Sarah E Clark, Jeanette E Purcell, Xuan Bi, Jeffrey D Fortman
Bordetella pseudohinzii is a microbial agent of potential importance in mice and has confounded pulmonary research at our institution. The purpose of this study was to evaluate cross-foster rederivation and antibiotic administration in the drinking water as methods to eradicate B. pseudohinzii. To evaluate the efficacy of cross-foster rederivation, 29 litters representing 16 strains of mice were cross-fostered from cages positive for B. pseudohinzii to B. pseudohinzii-negative Crl:CD1-Elite surrogate dams. To evaluate antibiotic administration, sulfamethoxazole and trimethoprim (TMS; 0...
January 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28884629/maternal-lifestyle-impairs-embryonic-growth-the-rotterdam-periconception-cohort
#9
Matthijs R Van Dijk, Nicole V Borggreven, Sten P Willemsen, Anton H J Koning, Régine P M Steegers-Theunissen, Maria P H Koster
Previously, embryonic growth has been assumed to be uniform, but in recent years, it has become more clear that genetic and environmental factors may influence the intrauterine environment and therefore embryonic growth trajectories as well as pregnancy course and outcome. The objective of this study was to investigate associations between modifiable maternal nutrition and lifestyle factors during the periconception period and embryonic growth. We established a prospective cohort including 342 women less than 13 weeks pregnant...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28861005/murine-myocardial-transcriptome-analysis-reveals-a-critical-role-of-cops8-in-the-gene-expression-of-cullin-ring-ligase-substrate-receptors-and-redox-and-vesicle-trafficking-pathways
#10
Ammara Abdullah, Kathleen M Eyster, Travis Bjordahl, Peng Xiao, Erliang Zeng, Xuejun Wang
Background: The COP9 signalosome (CSN) consisting of 8 unique protein subunits (COPS1 through COPS8) serves as the cullin deneddylase, regulating the catalytic dynamics of cullin RING ligases (CRLs), the largest family of ubiquitin ligases Background: The COP9 signalosome (CSN) consisting of 8 unique protein subunits (COPS1 through COPS8) serves as the cullin deneddylase, regulating the catalytic dynamics of cullin RING ligases (CRLs), the largest family of ubiquitin ligases. Supported primarily by the decrease of substrate receptor (SR) proteins of CRLs in cells deficient of a CSN subunit, CSN-mediated cullin deneddylation is believed to prevent autoubiquitination and self-destruction of the SR in active CRLs...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28851847/rotavirus-nsp1-requires-casein-kinase-ii-mediated-phosphorylation-for-hijacking-of-cullin-ring-ligases
#11
Kaitlin A Davis, Marco Morelli, John T Patton
The rotavirus nonstructural protein NSP1 repurposes cullin-RING E3 ubiquitin ligases (CRLs) to antagonize innate immune responses. By functioning as substrate adaptors of hijacked CRLs, NSP1 causes ubiquitination and proteasomal degradation of host proteins that are essential for expression of interferon (IFN) and IFN-stimulated gene products. The target of most human and porcine rotaviruses is the β-transducin repeat-containing protein (β-TrCP), a regulator of NF-κB activation. β-TrCP recognizes a phosphorylated degron (DSGΦXS) present in the inhibitor of NF-κB (IκB); phosphorylation of the IκB degron is mediated by IκB kinase (IKK)...
August 29, 2017: MBio
https://www.readbyqxmd.com/read/28832228/caffeic-acid-methyl-and-ethyl-esters-exert-potential-antidiabetic-effects-on-glucose-and-lipid-metabolism-in-cultured-murine-insulin-sensitive-cells-through-mechanisms-implicating-activation-of-ampk
#12
Hoda M Eid, Farah Thong, Abir Nachar, Pierre S Haddad
CONTEXT: Caffeic acid methyl (CAME) and ethyl (CAEE) esters stimulate glucose uptake and AMP-activated protein kinase (AMPK) in C2C12 myocytes (ATCC(®) CRL-1772(TM)). OBJECTIVE: Effects of CAME and CAEE were now assessed on myocyte glucose transporter GLUT4 activity and expression, on hepatic gluconeogenesis and on adipogenesis as well as major underlying signaling pathways. MATERIALS AND METHODS: GLUT4 protein translocation was studied in L6 GLUT4myc cells, glucose-6-phospatase (G6Pase) in H4IIE hepatocytes and adipogenesis in 3T3-L1 adipocytes...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28819300/yebc-a-putative-transcriptional-factor-involved-in-the-regulation-of-the-proteolytic-system-of-lactobacillus
#13
Lucía Brown, Josefina M Villegas, Mariano Elean, Silvina Fadda, Fernanda Mozzi, Lucila Saavedra, Elvira M Hebert
The proteolytic system of Lactobacillus plays an essential role in bacterial growth, contributes to the flavor development of fermented products, and can release bioactive health-beneficial peptides during milk fermentation. In this work, a genomic analysis of all genes involved in the proteolytic system of L. delbrueckii subsp. lactis CRL 581 was performed. Genes encoding the cell envelope-associated proteinase, two peptide transport systems, and sixteen peptidases were identified. The influence of the peptide supply on the transcription of 23 genes involved in the proteolytic system of L...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28810950/clofibrate-attenuates-ros-production-by-lipid-overload-in-cultured-rat-hepatoma-cells
#14
Yufei Chen, Wei Li, Guqi Wang, Frank J Burczynski
PURPOSE: To investigate the effect of clofibrate on inducing liver fatty acid binding protein (FABP1) following a high-fat load in a hepatocyte cell culture model. METHODS: Rat hepatoma cells (CRL-1548) were treated with a fatty acid (FA) mixture consisting of oleate:palmitate (2:1) in the presence of 3% albumin. Cells were treated with 0, 0.5, 1, 2, or 3 mM FA for 24 and 48 hr, or further treated with 500 µM clofibrate (CLO) to induce FABP1 levels. Cytotoxicity was determined using the WST-1 assay...
2017: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28802844/structural-basis-for-cullins-and-ring-component-inhibition-targeting-e3-ubiquitin-pathway-conductors-for-cancer-therapeutics
#15
Shagufta Shafique, Waqar Ali, Sonia Kanwal, Sajid Rashid
Cullin (CUL)-RING E3 ubiquitin ligases (CRLs) are attractive therapeutic targets as they regulate diverse biological processes important for cancer cell survival by conferring substrate selectivity for ubiquitination and degradation. Given the complexity of CRL complexes, steps toward the structure-based design of small-molecule inhibitors to modulate their activity have remained elusive. In this study, we explored the structural assembly and interaction details of closely related CUL scaffolds (CUL1, CUL2, CUL3, CUL4A, CUL4B, CUL5 and CUL7) with RBX1 to screen potent small molecules against CRLs...
August 10, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28802114/embryonic-and-fetal-morphology-in-the-lowland-paca-cuniculus-paca-a-precocial-hystricomorph-rodent
#16
Hani Rocha El Bizri, Frederico Ozanan Barros Monteiro, Rafael Dos Santos de Andrade, João Valsecchi, Diva Anelie de Araújo Guimarães, Pedro Mayor
In mammals, the embryonic and fetal development of a species has evolved to maximize neonatal survival. In this study, we use a sample of 132 embryos/fetuses of wild lowland paca (Cuniculus paca), obtained over a period of 15 years through collaborative methods with local hunters in the Amazon to describe the intrauterine development of external and internal morphology of this Neotropical rodent. We also compare the newborn survival strategy in this species with other rodents. The crown-rump length (CRL) ranged between 0...
August 3, 2017: Theriogenology
https://www.readbyqxmd.com/read/28794045/pseudorabies-virus-dutpase-ul50-induces-lysosomal-degradation-of-type-i-interferon-receptor-1-and-antagonizes-the-alpha-interferon-response
#17
Rui Zhang, Aotian Xu, Chao Qin, Qiong Zhang, Shifan Chen, Yue Lang, Mengdong Wang, Chuang Li, Wenhai Feng, Rui Zhang, Zhengfan Jiang, Jun Tang
Alphaherpesviruses that establish persistent infections rely partly on their ability to evade host antiviral responses, notably the type I interferon (IFN) response. However, the mechanisms employed by alphaherpesviruses to avoid this response are not well understood. Pseudorabies virus (PRV) is an economically important pathogen and a useful model system for studying alphaherpesvirus biology. To identify PRV proteins that antagonize type I IFN signaling, we performed a screen by using an IFN-stimulated response element reporter in the swine cell line CRL...
November 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28776111/methylene-blue-mediated-photobiomodulation-on-human-osteoblast-cells
#18
Gamze Bölükbaşı Ateş, Ayşe Ak, Bora Garipcan, Murat Gülsoy
Photobiomodulation (PBM) and photodynamic therapy (PDT) are two major methods, which use light in medicine and dentistry. PBM uses low-level laser light to induce cell proliferation and activity. In contrast, PDT use laser light combined with a photosensitizer (PS) to cause cell death. Due to similar, not fully understood mechanisms and biphasic response of light, unexpected and complex outcomes may be observed. In the present study, the effect of 635 nm laser light, with power density 50 mW/cm(2), at three different energy densities (0...
August 4, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28769978/ultrastructural-characteristics-of-rat-hepatic-oval-cells-and-their-intercellular-contacts-in-the-model-of-biliary-fibrosis-new-insights-into-experimental-liver-fibrogenesis
#19
Joanna Maria Lotowska, Maria Elzbieta Sobaniec-Lotowska, Dariusz Marek Lebensztejn, Urszula Daniluk, Piotr Sobaniec, Krzysztof Sendrowski, Jaroslaw Daniluk, Joanna Reszec, Wojciech Debek
PURPOSE: Recently, it has been emphasized that hepatic progenitor/oval cells (HPCs) are significantly involved in liver fibrogenesis. We evaluated the multipotential population of HPCs by transmission electron microscope (TEM), including relations with adherent hepatic nonparenchymal cells (NPCs) in rats with biliary fibrosis induced by bile duct ligation (BDL). METHODS: The study used 6-week-old Wistar Crl: WI(Han) rats after BDL for 1, 6, and 8 weeks. RESULTS: Current ultrastructural analysis showed considerable proliferation of HPCs in experimental intensive biliary fibrosis...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28764737/the-reproductive-pattern-and-potential-of-free-ranging-female-wild-boars-sus-scrofa-in-sweden
#20
Anna Malmsten, Gunnar Jansson, Nils Lundeheim, Anne-Marie Dalin
BACKGROUND: The number and spatial distribution of wild boars (Sus scrofa) has increased remarkably in Sweden as well as in other European countries. To understand the population dynamics of the wild boar, knowledge of its reproductive period, oestrus cycle and reproductive success is essential. The aim of this study was therefore to describe the seasonal reproductive pattern and reproductive potential of a wild boar population in Sweden. The study was based on findings from macroscopic examinations of the reproductive organs from 575 hunter-harvested female wild boars (>30 kg body weight)...
August 1, 2017: Acta Veterinaria Scandinavica
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