keyword
MENU ▼
Read by QxMD icon Read
search

NAE

keyword
https://www.readbyqxmd.com/read/28534922/fiber-purified-extracts-of-carob-fruit-decrease-carbohydrate-absorption
#1
A Macho-González, A Garcimartín, M E López-Oliva, G Bertocco, F Naes, S Bastida, F J Sánchez-Muniz, J Benedí
The postprandial state plays a central role in the development and setting of chronic diseases. Condensed tannins (CT) are polyphenols with a known ability to modify carbohydrate digestion and absorption. The high concentration of CT in the pulp of carob fruit suggests a potential antidiabetic effect. The aim of this work was to analyze the in vitro and in vivo effects of carob fruit extract (CFE) on the digestion and absorption of carbohydrates. α-Glucosidase activity and glucose diffusion were tested in vitro using 0...
May 23, 2017: Food & Function
https://www.readbyqxmd.com/read/28532595/impact-of-elemental-iron-on-human-spermatozoa-and-mouse-embryonic-development-in-a-defined-synthetic-culture-medium
#2
Safaa M Naes, Oshini Basri, Fauziah Ismail, Ghofraan A Ata'Allah, Siti Khadijah Idris, Noor Azmi Mat Adenan, Jaffar Ali
There is a paucity of studies on effect of iron in embryo culture procedures. This study aims to ascertain the optimal, tolerance and toxic levels of iron in a protein-free embryo culture medium (PFM) to determine the effect of iron on embryonic development. The application of PFM in assisted reproductive technologies (ART) is intended to eliminate disease transmission and improve ART treatment outcome. The optimal, tolerance and toxic levels of iron on human spermatozoa and mouse embryos were determined by challenging them with different levels of iron (ferric iron; Fe(+3))...
May 19, 2017: Reproductive Biology
https://www.readbyqxmd.com/read/28515018/plasma-levels-of-the-endocannabinoid-anandamide-related-n-acylethanolamines-and-linoleic-acid-derived-oxylipins-in-patients-with-migraine
#3
Sandra Gouveia-Figueira, Kristina Goldin, Sanaz A Hashemian, Agneta Lindberg, Monica Persson, Malin L Nording, Katarina Laurell, Christopher J Fowler
There is evidence that patients with migraine have deficient levels of the endogenous cannabinoid receptor ligand anandamide (AEA). It is not known, however, if this is a localised or generalised phenomenon. In the present study, levels of AEA, related N-acylethanolamines (NAEs) and linoleic acid-derived oxylipins have been measured in the blood of 26 healthy women and 38 women with migraine (26 with aura, 12 without aura) who were matched for age and body-mass index. Blood samples were taken on two occasions: the first sample near the start of the menstrual cycle (when present) and the second approximately fourteen days later...
May 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/28499828/estimating-the-future-burden-of-multidrug-resistant-and-extensively-drug-resistant-tuberculosis-in-india-the-philippines-russia-and-south-africa-a-mathematical-modelling-study
#4
Aditya Sharma, Andrew Hill, Ekaterina Kurbatova, Martie van der Walt, Charlotte Kvasnovsky, Thelma E Tupasi, Janice C Caoili, Maria Tarcela Gler, Grigory V Volchenkov, Boris Y Kazennyy, Olga V Demikhova, Jaime Bayona, Carmen Contreras, Martin Yagui, Vaira Leimane, Sang Nae Cho, Hee Jin Kim, Kai Kliiman, Somsak Akksilp, Ruwen Jou, Julia Ershova, Tracy Dalton, Peter Cegielski
BACKGROUND: Multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis are emerging worldwide. The Green Light Committee initiative supported programmatic management of drug-resistant tuberculosis in 90 countries. We used estimates from the Preserving Effective TB Treatment Study to predict MDR and XDR tuberculosis trends in four countries with a high burden of MDR tuberculosis: India, the Philippines, Russia, and South Africa. METHODS: We calibrated a compartmental model to data from drug resistance surveys and WHO tuberculosis reports to forecast estimates of incident MDR and XDR tuberculosis and the percentage of incident MDR and XDR tuberculosis caused by acquired drug resistance, assuming no fitness cost of resistance from 2000 to 2040 in India, the Philippines, Russia, and South Africa...
May 9, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28488728/fatty-acid-amide-hydrolase-faah-regulates-hypercapnia-ischemia-induced-increases-in-n-acylethanolamines-in-mouse-brain
#5
Lin Lin, Adam H Metherel, Peter J Jones, Richard P Bazinet
N-acylethanolamines (NAEs) are endogenous lipid ligands for several receptors including cannabinoid receptors and peroxisome proliferator-activated receptor-alpha (PPAR-α), which regulate numerous physiological functions. Fatty acid amide hydrolase (FAAH) is, largely, responsible for the degradation of NAEs. However, at high concentrations of ethanolamines and unesterified fatty acids, FAAH can also catalyze the reverse reaction, producing NAEs. Several brain insults such as ischemia and hypoxia increase brain unesterified fatty acids...
May 10, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28485567/stretchable-transparent-and-stretch-unresponsive-capacitive-touch-sensor-array-with-selectively-patterned-silver-nanowires-reduced-graphene-oxide-electrodes
#6
Taeyoung Choi, Byeong-Ung Hwang, Bo-Yeong Kim, Tran Quang Trung, Yun Hyoung Nam, Do-Nyun Kim, Kilho Eom, Nae-Eung Lee
Stretchable and transparent touch sensors are essential input devices for future stretchable transparent electronics. Capacitive touch sensors with a simple structure of only two electrodes and one dielectric are an established technology in current rigid electronics. However, the development of stretchable and transparent capacitive touch sensors has been limited due to changes in capacitance resulting from dimensional changes in elastomeric dielectrics and difficulty in obtaining stretchable transparent electrodes that are stable under large strains...
May 9, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28474207/severity-of-community-acquired-hypernatremia-is-an-independent-predictor-of-mortality
#7
Woo Jin Jung, Hee Jeong Lee, Suyeon Park, Si Nae Lee, Hye Ran Kang, Jin Seok Jeon, Hyunjin Noh, Dong Cheol Han, Soon Hyo Kwon
Hypernatremia develops commonly in critically ill patients during hospitalization, and is associated with adverse outcomes. However, community acquired hypernatremia (CAH) has been rarely studied. We conducted a study in patients who presented to an urban referral hospital, and were admitted with CAH. We retrospectively analyzed patients admitted to an urban tertiary care hospital from January 1, 2012 to December 31, 2014. CAH is defined as more than 147 mEq/L at admission in patients not transferred from other hospitals...
May 4, 2017: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/28471698/design-approaches-to-myocardial-and-vascular-tissue-engineering
#8
Olukemi O Akintewe, Erin G Roberts, Nae-Gyune Rim, Michael A H Ferguson, Joyce Y Wong
Engineered tissues represent an increasingly promising therapeutic approach for correcting structural defects and promoting tissue regeneration in cardiovascular diseases. One of the challenges associated with this approach has been the necessity for the replacement tissue to promote sufficient vascularization to maintain functionality after implantation. This review highlights a number of promising prevascularization design approaches for introducing vasculature into engineered tissues. Although we focus on encouraging blood vessel formation within myocardial implants, we also discuss techniques developed for other tissues that could eventually become relevant to engineered cardiac tissues...
May 3, 2017: Annual Review of Biomedical Engineering
https://www.readbyqxmd.com/read/28471354/introducing-biomimetic-shear-and-ion-gradients-to-microfluidic-spinning-improves-silk-fiber-strength
#9
David Li, Matthew Jacobsen, Nae Rim, Daniel Backman, David Kaplan, Joyce Y Wong
Silkworm silk is an attractive biopolymer for biomedical applications due to its high mechanical strength and biocompatibility; as a result, there is increasing interest in scalable devices to spin silk and recombinant silk so as to improve and customize their properties for diverse biomedical purposes.[1] While artificial spinning of regenerated silk fibroins adds tunability to properties such as degradation rate and surface functionalization, the resulting fibers do not yet approach the mechanical strength of native silkworm silk...
May 4, 2017: Biofabrication
https://www.readbyqxmd.com/read/28469786/mln4924-protects-against-bleomycin-induced-pulmonary-fibrosis-by-inhibiting-the-early-inflammatory-process
#10
Qi Deng, Jiaojiao Zhang, Yaqun Gao, Xiaofei She, Yunchao Wang, Yilin Wang, Xin Ge
Pulmonary fibrosis is a complex pathological process characterized by massive destruction of the structure of lung tissues and aggravated pulmonary function impairment. The underlying mechanisms of pulmonary fibrosis are incompletely understood and therefore limited treatment options are available currently. Here, we report that MLN4924, an NEDD8 activation enzyme (NAE) activity-inhibiting molecule, blocks the maintenance and progression of established pulmonary fibrosis. We found that MLN4924 acts against bleomycin-induced pulmonary fibrosis mainly at the early inflammatory stage...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28468780/combined-inhibition-of-nedd8-activating-enzyme-and-mtor-suppresses-nf2-loss-driven-tumorigenesis
#11
Jonathan Cooper, Qingwen Xu, Lu Zhou, Milica Pavlovic, Virginia Ojeda, Kamalika Moulick, Elisa de Stanchina, J T Poirier, Marjorie Zauderer, Charles M Rudin, Matthias A Karajannis, C Oliver Hanemann, Filippo G Giancotti
Inactivation of NF2/Merlin causes the autosomal dominant cancer predisposition syndrome Familial Neurofibromatosis Type 2 (NF2) and contributes to the development of malignant pleural mesothelioma (MPM). In order to develop a targeted therapy for NF2-mutant tumors, we have exploited the recent realization that Merlin loss drives tumorigenesis by activating the E3 ubiquitin ligase CRL4(DCAF1) - thereby inhibiting the Hippo pathway component Lats. Here, we show that MLN4924 - a NEDD8 activating enzyme (NAE) inhibitor - suppresses CRL4(DCAF1) and attenuates activation of YAP in NF2-mutant tumor cells...
May 3, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28460904/salivary-concentration-of-n-acylethanolamines-upon-food-mastication-and-after-meal-consumption-influence-of-food-dietary-fiber
#12
Xianghui Kong, Rosalia Ferracane, Lucia De Luca, Paola Vitaglione
The primary objective of this study was to evaluate the impact of the amount and type of food dietary fiber on salivary concentrations of N-acylethanolamines (NAEs) and glucose upon food mastication and in the post-prandial phase. Three types of biscuits enriched with 3% barley β-glucan (βGB) or whole-wheat bran (WWBB) or without dietary fiber (control, CB) were developed. A crossover randomized human study was carried out by collecting saliva samples from eighteen healthy and fasting participants in a resting condition, upon mastication of parafilm and one of the three biscuits...
November 2016: Food Research International
https://www.readbyqxmd.com/read/28457207/early-and-marked-enhancement-of-new-bone-quality-by-alendronate-loaded-collagen-sponge-combined-with-bone-morphogenetic-protein-2-at-high-dose-a-long-term-study-in-calvarial-defects-in-a-rat-model
#13
Tae Hyung Cho, In Sook Kim, Beomseok Lee, Si-Nae Park, Jae-Hyung Ko, Soon Jung Hwang
Choice of appropriate biomaterial is a key factor for the success of recombinant human bone morphogenetic protein (rhBMP)-2 therapy. Inspired by the osteogenic cell differentiating and osteoclast suppressing capabilities of alendronate (ALN), we manufactured a composite type of ALN-loaded collagen sponge (ALN-CS) which controls the early detrimental effect of high-dose rhBMP-2. This study aimed to evaluate ALN-CS as a high-dose rhBMP-2 carrier by investigating its initial bio-molecular effect and efficacy on intramembranous ossification at 1, 4, 8 and 24 weeks using a rat calvarial defect model, compared with non-loaded CS...
April 29, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28422718/validation-and-optimization-of-the-ion-torrent-s5-xl-sequencer-and-oncomine-workflow-for-brca1-and-brca2-genetic-testing
#14
Saeam Shin, Yoonjung Kim, Seoung Chul Oh, Nae Yu, Seung-Tae Lee, Jong Rak Choi, Kyung-A Lee
In this study, we validated the analytical performance of BRCA1/2 sequencing using Ion Torrent's new bench-top sequencer with amplicon panel with optimized bioinformatics pipelines. Using 43 samples that were previously validated by Illumina's MiSeq platform and/or by Sanger sequencing/multiplex ligation-dependent probe amplification, we amplified the target with the Oncomine™ BRCA Research Assay and sequenced on Ion Torrent S5 XL (Thermo Fisher Scientific, Waltham, MA, USA). We compared two bioinformatics pipelines for optimal processing of S5 XL sequence data: the Torrent Suite with a plug-in Torrent Variant Caller (Thermo Fisher Scientific), and commercial NextGENe software (Softgenetics, State College, PA, USA)...
May 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28416957/the-need-for-a-well-organized-video-assisted-asthma-education-program-at-korean-primary-care-clinics
#15
Yee Hyung Kim, Kwang Ha Yoo, Jee-Hong Yoo, Tae-Eun Kim, Deog Kyeom Kim, Yong Bum Park, Chin Kook Rhee, Tae-Hyung Kim, Young Sam Kim, Hyoung Kyu Yoon, Soo-Jung Um, I-Nae Park, Yon Ju Ryu, Jae-Woo Jung, Yong Il Hwang, Heung Bum Lee, Sung-Chul Lim, Sung Soo Jung, Eun-Kyung Kim, Woo Jin Kim, Sung-Soon Lee, Jaechun Lee, Ki Uk Kim, Hyun Kuk Kim, Sang Ha Kim, Joo Hun Park, Kyeong Cheol Shin, Kang Hyeon Choe, Ho-Kee Yum
BACKGROUND: The purpose of this study was to assess the effect of our new video-assisted asthma education program on patients' knowledge regarding asthma and asthma control. METHODS: Adult asthmatics who were diagnosed by primary care physicians and followed for at least 1 year were educated via smart devices and pamphlets. The education sessions were carried out three times at 2-week intervals. Each education period lasted at most 5 minutes. The effectiveness was then evaluated using questionnaires and an asthma control test (ACT)...
April 2017: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28398006/a-cost-analysis-of-implementing-a-behavioral-weight-loss-intervention-in-community-mental-health-settings-results-from-the-achieve-trial
#16
Ellen M Janssen, Gerald J Jerome, Arlene T Dalcin, Joseph V Gennusa, Stacy Goldsholl, Kevin D Frick, Nae-Yuh Wang, Lawrence J Appel, Gail L Daumit
OBJECTIVE: In the ACHIEVE randomized controlled trial, an 18-month behavioral intervention accomplished weight loss in persons with serious mental illness who attended community psychiatric rehabilitation programs. This analysis estimates costs for delivering the intervention during the study. It also estimates expected costs to implement the intervention more widely in a range of community mental health programs. METHODS: Using empirical data, costs were calculated from the perspective of a community psychiatric rehabilitation program delivering the intervention...
June 2017: Obesity
https://www.readbyqxmd.com/read/28396943/sonographic-differences-between-conventional-and-follicular-variant-papillary-thyroid-carcinoma
#17
Nicola M Hughes, Andreea Nae, Josephine Barry, Brendan Fitzgerald, Linda Feeley, Patrick Sheahan
Follicular variant papillary thyroid carcinoma (FVPTC) may pose a diagnostic challenge due to higher likelihood of lower risk cytology compared to conventional papillary thyroid carcinoma (CPTC). Recent guidelines have recommended the use of sonographic features to guide decisions to biopsy thyroid nodules. The purpose of this study was to evaluate the sonographic features of CPTC and FVPTC. This is a retrospective study design done in an Academic teaching hospital setting. Preoperative ultrasounds of 79 patients with conventional CPTC (48) and FVPTC (31) were reviewed by a radiologist blinded to histological diagnosis...
April 10, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28389507/coronary-computed-tomography-angiography-predicts-guidewire-crossing-and-success-of-percutaneous-intervention-for-chronic-total-occlusion-korean-multicenter-cto-ct-registry-score-as-a-tool-for-assessing-difficulty-in-chronic-total-occlusion-percutaneous-coronary
#18
MULTICENTER STUDY
Cheol-Woong Yu, Hyun-Jong Lee, Jon Suh, Nae-Hee Lee, Sang-Min Park, Taek Kyu Park, Jeong Hoon Yang, Young Bin Song, Joo-Yong Hahn, Seung Hyuk Choi, Hyeon-Cheol Gwon, Sang-Hoon Lee, Yeon Hyeon Choe, Sung Mok Kim, Jin-Ho Choi
BACKGROUND: We developed a model that predicts difficulty of percutaneous coronary intervention for coronary chronic total occlusion (CTO) using coronary computed tomographic angiography. METHODS AND RESULTS: A total of 684 CTO lesions with preprocedural computed tomographic angiography were enrolled from 4 centers. Data were randomly divided into derivation and validation datasets at 2:1 ratio. The end point was successful guidewire crossing ≤30 minutes, which was met in 50%...
April 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28388520/discovery-of-benzothiazole-derivatives-as-novel-non-sulfamide-nedd8-activating-enzyme-inhibitors-by-target-based-virtual-screening
#19
Hao Ma, Chunlin Zhuang, Xiguo Xu, Jiao Li, Juan Wang, Xiao Min, Wannian Zhang, Huojun Zhang, Zhenyuan Miao
NEDD8 activating enzyme (NAE) plays a critical role in various cellular functions in cancers. In this study, a target-based virtual screening was applied to discover benzothiazoles to be potent non-covalent NAE inhibitors. Further two round optimizations concluded a preliminary structure-activity relationship (SAR) of their derivatives. Three compounds (6k, 7b, ZM223) exhibited antitumor activities in nanomolar range. ZM223 showed excellent anticancer activity against HCT116 colon cancer cells with an IC50 value of 100 nM...
March 31, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28378749/silk-fibronectin-protein-alloy-fibres-support-cell-adhesion-and-viability-as-a-high-strength-matrix-fibre-analogue
#20
Matthew M Jacobsen, David Li, Nae Gyune Rim, Daniel Backman, Michael L Smith, Joyce Y Wong
Silk is a natural polymer with broad utility in biomedical applications because it exhibits general biocompatibility and high tensile material properties. While mechanical integrity is important for most biomaterial applications, proper function and integration also requires biomaterial incorporation into complex surrounding tissues for many physiologically relevant processes such as wound healing. In this study, we spin silk fibroin into a protein alloy fibre with whole fibronectin using wet spinning approaches in order to synergize their respective strength and cell interaction capabilities...
April 5, 2017: Scientific Reports
keyword
keyword
111231
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"