keyword
MENU ▼
Read by QxMD icon Read
search

NAE

keyword
https://www.readbyqxmd.com/read/29436743/plasma-n-acylethanolamine-and-endocannabinoid-levels-in-burning-mouth-syndrome-potential-role-in-disease-pathogenesis
#1
Alison Barry, Ken D O'Halloran, Joseph P McKenna, Christine McCreary, Brendan Harhen, Daniel M Kerr, David P Finn, Eric J Downer
OBJECTIVE: The objective was to measure endocannabinoid (eCB) ligands and non-cannabinoid N-acylethanolamine (NAE) molecules in plasma from individuals with burning mouth syndrome (BMS), and to determine if plasma eCB/NAE levels correlated with pain, inflammation and depressive symptomatology in this cohort. STUDY DESIGN: Plasma content of the eCBs, anandamide (AEA) and 2-arachidonoyl-glycerol (2-AG), and the NAE molecules, palmitoylethanolamide (PEA) and oleolylethanolamide (OEA), were assessed in healthy subjects (n=8) and in a cohort of newly diagnosed BMS patients (n=9) using liquid chromatography-tandem mass spectrometry...
February 13, 2018: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29433564/high-dose-thiotepa-related-neurotoxicity-and-the-role-of-tramadol-in-children
#2
Christophe Maritaz, Francois Lemare, Agnes Laplanche, Sylvie Demirdjian, Dominique Valteau-Couanet, Christelle Dufour
BACKGROUND: Serious neurological adverse events (NAE) have occurred during treatment with high-dose thiotepa regimens of children with high-risk solid tumours. The objective was to assess the incidence of NAE related to high-dose thiotepa and to identify potential contributing factors that could exacerbate the occurrence of this neurotoxicity. METHODS: From May 1987 to March 2011, children with solid tumours treated with high-dose thiotepa were retrospectively identified...
February 13, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29392596/team-based-health-information-exchange-use-increased-mammography-documentation-and-referral-in-an-academic-primary-care-practice-an-interrupted-time-series
#3
Samantha I Pitts, Nisa M Maruthur, Xiao Wang, Melinda D Sawyer, Renee Grimes, Candace Nigrin, Jeanne M Clark, Nae-Yuh Wang, Heather F Sateia, Kimberly S Peairs
BACKGROUND: Few studies have examined the impact of health information exchanges (HIE) on quality in ambulatory settings. METHODS: From September 29, 2014, to September 4, 2015, we conducted an interrupted time series analysis of query-based use of the state HIE as part of team-based care to improve mammography screening in an academic primary care practice. Women aged 50-74 years with a practice visit and who were eligible for mammography were included. We conducted non-parametric data analysis using LOESS, followed by ARIMA analysis...
February 1, 2018: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29391311/shorter-waiting-times-from-education-to-colonoscopy-can-improve-the-quality-of-bowel-preparation-a-randomized-controlled-trial
#4
Jin Lee, Tae Oh Kim, Joo Wan Seo, Joon Hyuk Choi, Nae Yun Heo, Jongha Park, Seung Ha Park, Sung Yeon Yang, Young Soo Moon
BACKGROUND/AIMS: Adequate bowel preparation is essential for an effective and safe colonoscopy. This study aimed to evaluate the quality of bowel preparation according to waiting times from education to colonoscopy. MATERIALS AND METHODS: A prospective, investigator-blinded, randomized study was performed from December 2016 to March 2017. Patients were divided into two groups: within 2 weeks (group A, n=64) or more than 2 weeks (group B, n=66) from education about bowel preparation to colonoscopy...
January 2018: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/29387232/mln4924-neddylation-inhibitor-promotes-cell-death-in-paclitaxel-resistant-human-lung-adenocarcinoma-cells
#5
Qiang Xu, Guibin Lin, Huizhe Xu, Lulu Hu, Yupeng Wang, Sha Du, Wuguo Deng, Wenxian Hu, Wei Cheng, Ke Jiang
Acquired resistance to first-line chemotherapeutics, including paclitaxel (PTX), is a primary factor contributing to chemotherapy failure in non-small cell lung cancer (NSCLC) patients. Previous studies have identified that targeting NEDD8-activating enzyme (NAE) with MLN4924 effectively overcomes platinum resistance in preclinical models of ovarian cancer. However, the underlying mechanisms are yet to be fully elucidated. The present study demonstrates that the inhibition of the neddylation pathway with MLN4924 an NAE inhibitor inhibited protein neddylation, inactivated cullin-RING E3 ligase and exhibited a potent antiproliferative effect on PTX-resistant A549 and H460 cells (A549/PTX and H460/PTX)...
January 2018: Oncology Letters
https://www.readbyqxmd.com/read/29348517/ndrg2-contributes-to-cisplatin-sensitivity-through-modulation-of-bak-to-mcl-1-ratio
#6
Soojong Park, Sang-Seok Oh, Ki Won Lee, Yeon-Kyeong Lee, Nae Yu Kim, Joo Heon Kim, Jiyun Yoo, Kwang Dong Kim
The downregulation of N-Myc downstream-regulated gene 2 (NDRG2) is known to be associated with the progression and poor prognosis of several cancers. Sensitivity to anti-cancer may be associated with a good prognosis in cancer patients, and NDRG2, which is induced by p53, sensitizes the cells to chemotherapy. However, the unique function of NDRG2 as an inducer of apoptosis under chemotreatment has not been sufficiently studied. In this study, we investigated the role of NDRG2 in chemo-sensitivity, focusing on cisplatin in U937 histiocytic lymphoma, which has the loss-of-functional mutation in p53...
January 18, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29348128/pevonedistat-a-first-in-class-nedd8-activating-enzyme-nae-inhibitor-combined-with-azacitidine-in-patients-with-aml
#7
Ronan T Swords, Steven Coutre, Michael B Maris, Joshua F Zeidner, James M Foran, Jose Cruz, Harry P Erba, Jesus G Berdeja, Wayne Tam, Saran Vardhanabhuti, Iwona Pawlikowska-Dobler, Hélène M Faessel, Ajeeta B Dash, Farhad Sedarati, Bruce J Dezube, Douglas V Faller, Michael R Savona
Pevonedistat (TAK-924/MLN4924) is a novel inhibitor of NEDD8-activating enzyme (NAE) with single-agent activity in relapsed/refractory acute myeloid leukemia (AML). We performed a phase 1b study (NCT01814826) of pevonedistat (PEV) with azacitidine (AZA) based on synergistic activity seen preclinically. Primary objectives included safety and tolerability, and secondary objectives included pharmacokinetics (PK) and disease response. Patients ≥60 years with treatment-naïve AML, unfit for standard induction therapy, received PEV 20 or 30 mg/m2 IV on days 1, 3, and 5, combined with fixed-dose AZA (75 mg/m2 IV/SC) on days 1-5, 8, and 9, every 28 days...
January 18, 2018: Blood
https://www.readbyqxmd.com/read/29342111/cytotoxicity-evaluation-of-turmeric-extract-incorporated-oil-in-water-nanoemulsion
#8
Hee Jeong Yoon, Xiaowei Zhang, Min Gyeong Kang, Gyeong Jin Kim, Sun Young Shin, Sang Hong Baek, Bom Nae Lee, Su Jung Hong, Jun Tae Kim, Kwonho Hong, Hojae Bae
To overcome the drawbacks of conventional drug delivery system, nanoemulsion have been developed as an advanced form for improving the delivery of active ingredients. However, safety evaluation is crucial during the development stage before the commercialization. Therefore, the aim of this study was to evaluate the cytotoxicity of two types of newly developed nanoemulsions. Turmeric extract-loaded nanoemulsion powder-10.6 (TE-NEP-10.6, high content of artificial surfactant Tween 80), which forms the optimal nanoemulsion, and the TE-NEP-8...
January 17, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29337083/palmitoylethanolamide-attenuates-cocaine-induced-behavioral-sensitization-and-conditioned-place-preference-in-mice
#9
Emma Zambrana-Infantes, Cristina Rosell Del Valle, David Ladrón de Guevara-Miranda, Pablo Galeano, Estela Castilla-Ortega, Fernando Rodríguez De Fonseca, Eduardo Blanco, Luis Javier Santín
Cocaine addiction is a chronically relapsing disorder characterized by compulsive drug-seeking and drug-taking behaviors. Previous studies have demonstrated that cocaine, as well as other drugs of abuse, alters the levels of lipid-based signaling molecules, such as N-acylethanolamines (NAEs). Moreover, brain levels of NAEs have shown sensitivity to cocaine self-administration and extinction training in rodents. Given this background, the aim of this study was to investigate the effects of repeated or acute administration of palmitoylethanolamide (PEA), an endogenous NAE, on psychomotor sensitization and cocaine-induced contextual conditioning...
January 11, 2018: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/29317248/cognitive-decline-and-increased-hippocampal-p-tau-expression-in-mice-with-hearing-loss
#10
So Young Park, Min Jung Kim, Hong Lim Kim, Dong Kee Kim, Sang Won Yeo, Shi Nae Park
Hearing and cognition are commonly involved in both normal and pathological aging. Current clinical interest lies in whether peripheral hearing loss promotes cognitive decline. In our previous publication, the authors have shown a causal relationship between hearing and cognitive impairments in C57BL/6 mice. Here we extended the follow-up to 12 months to determine the long-term effects of hearing loss on cognition and to observe hippocampal p-tau and lipofuscin. One month old male mice were randomly allocated into two groups, the control (n = 12) and noise-induced hearing loss (NIHL) (n = 12)...
January 6, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29313885/interferon-%C3%AE-treatment-increases-endocannabinoid-and-related-n-acylethanolamine-levels-in-t84-human-colon-carcinoma-cells
#11
Mireille Alhouayek, Linda Rankin, Sandra Gouveia-Figueira, Christopher J Fowler
BACKGROUND AND PURPOSE: Endocannabinoids and related N-acylethanolamines (NAEs) are involved in regulation of gut function, but relatively little is known as to whether inflammatory cytokines such as interferon γ (IFNγ) affect their levels. We have investigated this in vitro using T84 colon cancer cells, which when cultured in monolayers differentiate to form adult colonic crypt-like cells with excellent permeability barrier properties. EXPERIMENTAL APPROACH: NAE levels were determined by ultra-performance liquid chromatography-tandem mass spectrometric analysis...
January 3, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29307005/effect-of-cerebral-embolus-size-on-the-timing-of-cardiac-surgery-for-infective-endocarditis-in-patients-with-neurological-complications
#12
Yong Kyun Kim, Choong Gon Choi, Jiwon Jung, Shi Nae Yu, Ju Young Lee, Yong Pil Chong, Sung-Han Kim, Sang-Oh Lee, Sang-Ho Choi, Jun Hee Woo, Yang Soo Kim
The optimal timing of cardiac surgery remains unclear for patients with neurological complications of infective endocarditis (IE). However, neuroimaging findings may allow more refined clinical decision-making. We analyzed clinical and advanced neuroimaging data for 135 patients with IE who had preoperatively diagnosed ischemic cerebral complications (86 patients) or hemorrhagic complications (49 patients), between January 1997 and May 2013. The effect of early surgery (within 3 and 7 days of ischemic and hemorrhagic complications respectively) on in-hospital mortality and 1-year adverse outcomes (mortality, relapse, or new embolic events) was estimated...
January 6, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29295910/range-expansion-and-the-origin-of-usa300-north-american-epidemic-methicillin-resistant-staphylococcus-aureus
#13
Lavanya Challagundla, Xiao Luo, Isabella A Tickler, Xavier Didelot, David C Coleman, Anna C Shore, Geoffrey W Coombs, Daniel O Sordelli, Eric L Brown, Robert Skov, Anders Rhod Larsen, Jinnethe Reyes, Iraida E Robledo, Guillermo J Vazquez, Raul Rivera, Paul D Fey, Kurt Stevenson, Shu-Hua Wang, Barry N Kreiswirth, Jose R Mediavilla, Cesar A Arias, Paul J Planet, Rathel L Nolan, Fred C Tenover, Richard V Goering, D Ashley Robinson
The USA300 North American epidemic (USA300-NAE) clone of methicillin-resistant Staphylococcus aureus has caused a wave of severe skin and soft tissue infections in the United States since it emerged in the early 2000s, but its geographic origin is obscure. Here we use the population genomic signatures expected from the serial founder effects of a geographic range expansion to infer the origin of USA300-NAE and identify polymorphisms associated with its spread. Genome sequences from 357 isolates from 22 U.S...
January 2, 2018: MBio
https://www.readbyqxmd.com/read/29260167/hierarchical-tio2-x-imbedded-with-graphene-quantum-dots-for-high-performance-lithium-storage
#14
Weifeng Zhang, Tan Xu, Zhenwei Liu, Nae-Lih Wu, Mingdeng Wei
Hierarchical TiO2-x imbedded with graphene quantum dots was synthesized through a facile synthetic route and investigated as an anode material for lithium-ion batteries. It delivers a high specific capacity and excellent rate capability (160.1 mA h g-1 at 10 C after 500 cycles).
December 20, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29245329/dural-sac-area-is-a-more-sensitive-parameter-for-evaluating-lumbar-spinal-stenosis-than-spinal-canal-area-a-retrospective-study
#15
Young Su Lim, Jong-Uk Mun, Mi Sook Seo, Bo-Hyun Sang, Yun-Sic Bang, Keum Nae Kang, Jin Woo Koh, Young Uk Kim
Narrowing of the dural sac cross-sectional area (DSCSA) and spinal canal cross-sectional area (SCCSA) have been considered major causes of lumbar central canal spinal stenosis (LCCSS). DSCSA and SCCSA were previously correlated with subjective walking distance before claudication occurs, aging, and disc degeneration. DSCSA and SCCSA have been ideal morphological parameters for evaluating LCCSS. However, the comparative value of these parameters is unknown and no studies have evaluated the clinical optimal cut-off values of DSCSA and SCCSA...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29235594/salivary-endocannabinoids-and-n-acylethanolamines-upon-mastication-of-a-semisolid-food-implications-in-fat-taste-appetite-and-food-liking
#16
Ilario Mennella, Rossella Di Monaco, Adriana Balazy, Rosalia Ferracane, Nicoletta A Miele, Silvana Cavella, Paola Vitaglione
This study aimed to evaluate whether salivary endocannabinoid (EC) and N-acylethanolamine (NAE) concentrations upon mastication of a semisolid food were involved in the sensory perception of fat taste, food liking and appetite in humans. A fat-enriched (FEP) and a low-fat control (CP) pudding were developed and used in a randomized cross-over study with 19 healthy volunteers. The study protocol combined a Modified Sham-Feeding (MSF) with a multiple-spoon Temporal Dominance of Sensations method. Subjects masticated and expectorated 10 spoons of the pudding and selected the dominant sensations among a list of attributes...
December 13, 2017: Food & Function
https://www.readbyqxmd.com/read/29233905/neddylation-blockade-diminishes-hepatic-metastasis-by-dampening-cancer-stem-like-cells-and-angiogenesis-in-uveal-melanoma
#17
Yanli Jin, Ping Zhang, Yun Wang, Bei Jin, Jingfeng Zhou, Jing Zhang, Jingxuan Pan
PURPOSE: Liver metastasis is the major and direct cause of death in patients with uveal melanoma (UM). There is no effective therapy for patients with metastatic UM. Improved treatments of hepatic metastatic patients with UM were urgently needed. Inspired by readily detectable key components in neddylation pathway in UM cells, we aimed at exploring whether neddylation pathway was a therapeutic target for liver metastatic UM. EXPERIMENTAL DESIGN: Expression of key proteins in neddylation pathway in UM was detected by Western blotting, real-time quantitative RT-PCR (qRT-PCR), and immunohistochemical staining...
December 12, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29232579/structure-based-identification-of-a-nedd8-activating-enzyme-inhibitor-via-drug-repurposing
#18
Ke-Jia Wu, Hai-Jing Zhong, Guodong Li, Chenfu Liu, Hui-Min David Wang, Dik-Lung Ma, Chung-Hang Leung
NEDD8-activating enzyme (NAE) is an essential player of the NEDD8 conjugation pathway that regulates protein degradation. Meanwhile, drug repurposing is a cost-efficient strategy to identify new therapeutic uses for existing scaffolds. In this report, mitoxantrone (1) was repurposed as an inhibitor of NAE by virtual screening of an FDA-approved drug database. Compound 1 inhibited NAE activity in cell-free and cell-based systems with high selectivity and was competitive with ATP. Furthermore, compound 1 induced apoptosis of colorectal adenocarcinoma cancer cells through inhibiting the degradation of the neddylation substrate p53...
December 6, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29222451/alternate-partial-root-zone-drip-irrigation-improves-water-and-nitrogen-use-efficiencies-of-sweet-waxy-maize-with-nitrogen-fertigation
#19
Fengbei Fu, Fusheng Li, Shaozhong Kang
Alternate partial root-zone drip irrigation (ADI) or fertigation has favorable effect on crop water- and nitrogen- use efficiencies (WUE and NUE). However, the advantage of combined application of ADI and nitrogen fertigation on crop WUE and NUE remains unclear. A pot experiment was conducted to investigate the impact of three irrigation methods (CDI conventional drip irrigation (both halves of pot irrigated), ADI (both halves of pot alternatively irrigated) and FDI fixed partial root-zone drip irrigation (fixed half of pot irrigated)) and five nitrogen treatments (F0 no N supplied, F1-F4 0...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29219391/observation-of-bogoliubov-band-hybridization-in-the-optimally-doped-trilayer-bi_-2-sr_-2-ca_-2-cu_-3-o_-10-%C3%AE
#20
So Kunisada, Shintaro Adachi, Shiro Sakai, Nae Sasaki, Mitsuhiro Nakayama, Shuntaro Akebi, Kenta Kuroda, Takao Sasagawa, Takao Watanabe, Shik Shin, Takeshi Kondo
Using a laser-excited angle-resolved photoemission spectroscopy capable of bulk sensitive and high-energy resolution measurements, we reveal a new phenomenon of superconductors in the optimally doped trilayer Bi_{2}Sr_{2}Ca_{2}Cu_{3}O_{10+δ}. We observe a hybridization of the Bogoliubov bands derived from the inner and outer CuO_{2} planes with different magnitudes of energy gaps. Our data clearly exhibit the splitting of coherent peaks and the consequent enhancement of spectral gaps. These features are reproduced by model calculations, which indicate that the gap enhancement extends over a wide range of Fermi surface up to the antinode...
November 24, 2017: Physical Review Letters
keyword
keyword
111231
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"