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M K Shea, C H Gilhooly, B Dawson-Hughes
BACKGROUND/OBJECTIVES: Acid-producing diets have been associated with adverse health conditions. Dietary acid load can be estimated from dietary intake data, but the available methods require a full dietary assessment. We sought to identify a simpler means to estimate 24-h urinary net acid excretion (NAE), a robust measure of net endogenous acid production, using self-reported intakes of fruits, vegetables (acid-neutralizing foods), grain and/or protein (acid-producing foods) acquired by two different methods in community-dwelling older adults...
October 19, 2016: European Journal of Clinical Nutrition
Oscar Prospéro-García, Octavio Amancio-Belmont, Alline L Becerril Meléndez, Alejandra E Ruiz-Contreras, Mónica Méndez-Díaz
Sleep is regulated by several brain structures, neurotransmitters and neuromodulators. Endocannabinoids (eCBs) are a group of lipids with modulatory activity in the brain and bind mainly to cannabinoid receptors CB1R and CB2R, thereby modulating several brain functions, (memory, mood, food intake, pain perception). Oleoylethanolamide and palmitoylethanolamide belong to the N-acylethanolamides (NAEs) family, another type of active endogenous lipids. They bind to the peroxisome proliferator-activated receptor α but not to CB1R, thereby modulating food satiety, inflammation and pain...
October 15, 2016: Neuroscience and Biobehavioral Reviews
Atsushi Miyajima, Takashi Hirota, Mari Tashiro, Wataru Noguchi, Yayoi Kawano, Takehisa Hanawa, Akira Kigure, Taichi Anata, Yosuke Yamamoto, Nae Yuasa, Machi Koshino, Yumi Shiraishi, Kaoru Yuzawa, Keita Akagi, Takashi Yoshimasu, Kuniko Makigami, Masayo Komoda
As a novel administration method of ivermectin (IVM) for scabies treatment, we proposed a "whole-body bathing method (WBBM)". In this method, the patients would bathe themselves in a bathing fluid containing IVM at an effective concentration. Previously, we demonstrated that WBBM could deliver IVM to the skin but not to the plasma in rats. In the present study, to assess the clinical validity of the method an arm bathing examination (first trial) and a whole-body bathing examination (second trial) were conducted in healthy volunteers...
October 15, 2016: Journal of Dermatology
Sang-Hyun Kim, Sang-Ho Jo, Sang-Cheol Lee, Sung-Yoon Lee, Myung-Ho Yoon, Hyang-Lim Lee, Nae-Hee Lee, Jong-Won Ha, Nam-Ho Lee, Dong-Woon Kim, Gyu-Rok Han, Min-Su Hyon, Deok-Gyu Cho, Chang-Gyu Park, Young-Dae Kim, Gyu-Hyung Ryu, Cheol-Ho Kim, Kee-Sik Kim, Myung-Ho Chung, Sung-Chul Chae, Ki-Bae Seung, Byung-Hee Oh
PURPOSE: A fixed-dose combination of a stain and an antihypertensive drug may be useful for the treatment of patients with hypertension and hyperlipidemia. It may also improve patient drug compliance to help control risk factors of cardiovascular disease. This study was designed to evaluate the blood pressure-lowering and cholesterol-lowering effect of a fixed-dose combination of irbesartan-atorvastatin compared with monotherapy by either agent over an 8-week treatment period. METHODS: Patients with comorbid hypertension and hypercholesterolemia were screened for this randomized, double-blind, Phase III study...
October 11, 2016: Clinical Therapeutics
Jin Yong Shin, Si-Gyun Roh, Nae-Ho Lee, Kyung-Moo Yang
BACKGROUND: There are many treatment modalities associated with osmidrosis. The purpose of this study was to identify and compare effective osmidrosis treatments. METHODS: A systematic literature review and meta-analysis were performed using MEDLINE, EMBASE, and Cochrane databases. The osmidrosis treatment modalities were extracted as predictor variables, and recurrence and complications were extracted as outcome variables. Subgroup analysis was performed with regard to combined curettage, and fixed and random effect models were applied...
October 6, 2016: Annals of Plastic Surgery
Nae-Wen Kuo, Shih-Hao Jien, Nien-Ming Hong, Yao-Te Chen, Tsung-Yu Lee
A previous study has demonstrated that Danshui River has almost the highest dissolved inorganic nitrogen (DIN) yield in the world and exports most of the DIN in the form of ammonium unlike the world's large rivers. However, the DIN sources are poorly constrained. In this study, the contributions of major sources in the Taipei metropolitan area to the DIN export in the Danshui River were investigated. It is observed that ammonium is the major DIN species in the downstream reaches, resulting from the ammonium-dominated inputs of the effluents of wastewater treatment plants (WWTP) and rain water pumping stations (RWPS)...
October 13, 2016: Environmental Science and Pollution Research International
Sherita Hill Golden, Nina Shah, Mohammad Naqibuddin, Jennifer L Payne, Felicia Hill-Briggs, Gary S Wand, Nae-Yuh Wang, Susan Langan, Constantine Lyketsos
OBJECTIVE: To estimate the crude prevalence of minor depressive disorder (MinD) in a clinic-based population of adults with type 2 diabetes. METHODS: We screened a clinical sample of 702 adults with type 2 diabetes for depressive symptoms using the Patient Health Questionnaire-2 and performed a structured diagnostic psychiatric interview on 52 screen-positive and a convenience sample of 51 screen-negative individuals. Depressive disorder diagnoses were made using Diagnostic and Statistical Manual of Mental Disorders IV (DSM-IV) Text Revised criteria and categorized as MinD, major depressive disorder (MDD), or no depressive disorder...
August 15, 2016: Psychosomatics
Jin Yong Shin, Jin Soo Kim, Si-Gyun Roh, Nae-Ho Lee, Kyung-Moo Yang
BACKGROUND: The barbed suture technique uses newly developed materials for flexor tendon repair. In this study, the authors examine the effectiveness of using barbed sutures in flexor tendon repair compared with conventional methods. METHODS: A systematic literature review and meta-analysis was performed using MEDLINE, Embase, and Cochrane databases. Barbed suture and conventional suture methods were extracted as predictor variables, and maximum force, gap formation force, and cross-sectional area were extracted as outcome variables...
October 2016: Plastic and Reconstructive Surgery
Young Soo Chung, Si-Nae Park, Jae Hyung Ko, Sang Hee Bae, Song Lee, In Kyong Shim, Song Cheol Kim
BACKGROUND: Collagen exhibits ideal multifactorial action for preventing tissue adhesions. This study examined the efficacy of ionized collagen in preventing tissue adhesion after surgical procedures. MATERIALS AND METHOD: Ionized collagen was prepared using the esterification technique of natural collagen. Three forms of collagen materials (membrane, film, and gel) were compared with three commercialized materials (oxidized regenerated cellulose membrane [OC membrane], hyaluronic acid and carboxymethylcellulose film, and gel [HC film and HC gel]) in a rat cecum abrasion model...
October 2016: Journal of Surgical Research
Tanapon Phenrat, Pimpawat Teeratitayangkul, Isarawut Prasertsung, Rattapoohm Parichatprecha, Peerapong Jitsangiam, Narong Chomchalow, Siriwan Wichai
This research evaluated the feasibility of using vetiver plantlets (Vetiveria zizanioides (L.) Nash) on a floating platform with aeration to degrade phenol (500 mg/L) in illegally dumped industrial wastewater (IDIWW). The IDIWW sample was from the most infamous illegal dumping site at Nong Nae subdistrict, Phanom Sarakham district, Chachoengsao province, Thailand. Laboratory results suggested that phenol degradation by vetiver involves two phases: Phase I, phytopolymerization and phyto-oxidation assisted by root-produced peroxide (H2O2) and peroxidase (POD), followed by phase II, a combination of phase I with enhanced rhizomicrobial degradation...
September 24, 2016: Environmental Science and Pollution Research International
Nae Tanpradit, Kaywalee Chatdarong, Pierre Comizzoli
PURPOSE: Temporary and reversible downregulation of metabolism may improve the survival of tissues exposed to non-physiological conditions during transport, in vitro culture, and cryopreservation. The objectives of the study were to (1) optimize the concentration and duration of carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone (FCCP-a mitochondrial uncoupling agent) exposures for biopsies of domestic cat ovarian tissue and (2) examine the effects of FCCP pre-exposures on follicle integrity after tissue culture and/or cryopreservation...
September 17, 2016: Journal of Assisted Reproduction and Genetics
Jung-Soo Pyo, Nae Yu Kim, Roy Hyun Jai Kim, Guhyun Kang
The study investigated isocitrate dehydrogenase (IDH) 1 immunohistochemistry (IHC) positive rate and concordance rate between IDH1 IHC and molecular test in glioblastoma. The current study included 1360 glioblastoma cases from sixteen eligible studies. Meta-analysis, including subgroup analysis by antibody clones and cut-off values, for IDH1 IHC positive rate was conducted. In addition, we performed a concordance analysis and diagnostic test accuracy review between IDH1 IHC and molecular tests. The estimated rates of IDH1 IHC were 0...
October 2016: Brain Tumor Pathology
Haekyung Lee, Dohui Hwang, Minchul Jeon, Eunjung Lee, Taehyong Kim, Shi Nae Yu, Yongbeom Kim, Byung-Ill Lee
BACKGROUND: There are increasing reports on nosocomial Mycobacterium massiliense infection, but septic arthritis and osteomyelitis because of that microorganism is rare. This report focuses on the clinical aspects of M. massiliense arthritis outbreak concurrent with soft tissue infection. CASE PRESENTATION: An outbreak of septic arthritis among patients who had been injected at a single clinic occurred in South Korea between April and September 2012. This may be associated with repeated injection of triamcinolone contaminated with M...
2016: BMC Research Notes
Meredith J Cler, Yu-An S Lien, Maia N Braden, Talia Mittelman, Kerri Downing, Cara E Stepp
Purpose: This article describes the development and initial validation of an objective measure of nasal air emission (NAE) using nasal accelerometry. Method: Nasal acceleration and nasal airflow signals were simultaneously recorded while an expert speech language pathologist modeled NAEs at a variety of severity levels. In addition, microphone and nasal accelerometer signals were collected during the production of /pɑpɑpɑpɑ/ speech utterances by 25 children with and without cleft palate...
September 9, 2016: Journal of Speech, Language, and Hearing Research: JSLHR
Shuju Zhang, Jiaming Zhang, Zhiyuan Deng, Huadie Liu, Wei Mao, Fang Jiang, Zanxian Xia, Jia-Da Li
The anticancer small molecule MLN4924, a Nedd8-activating enzyme (NAE) inhibitor, triggers cell-cycle arrest, apoptosis, and senescence in cancer cells. In this study, we demonstrate that MLN4924 suppresses osteosarcoma cell proliferation by inducing G2/M cell cycle arrest and apoptosis. Our results indicate that MLN4924 stabilizes the retinoid orphan nuclear receptor alpha (RORα) by decreasing its ubiquitination. RNA interference of RORα attenuates the anti-proliferative effect of MLN4924 in U2OS osteosarcoma cells...
September 1, 2016: Oncotarget
Miran Han, Jin Wook Choi, Nae-Jung Rim, Sun Yong Kim, Hong-Il Suh, Kyu Sun Lee, Ji Man Hong, Jin Soo Lee
Patients who have large cerebral infarctions may not be good candidates for endovascular treatment. Various methods for determining infarct volume have been used in clinical studies. We evaluated the effectiveness of several methods for measuring infarct volume, especially regarding futile outcomes despite endovascular treatment.Patients with acute ischemic stroke in unilateral anterior circulation territory who were treated with intra-arterial thrombectomy were included. For assessing infarct volume, the Alberta Stroke Program Early Computed Tomography Score (ASPECTS) scoring system was applied to images obtained by noncontrast computed tomography (NCCT), postcontrast CT (PCCT), and diffusion-weighted imaging (DWI)...
August 2016: Medicine (Baltimore)
Helle A Hassing, Suzan Fares, Olav Larsen, Hamideh Pad, Maria Hauge, Robert M Jones, Thue W Schwartz, Harald S Hansen, Mette M Rosenkilde
GPR119 is a Gαs-coupled lipid-sensor in the gut, where it mediates release of incretin hormones from the enteroendocrine cells and in pancreatic α-cells, where it releases insulin. Naturally occurring lipids such as monoacylglycerols (MAGs) and N-acylethanolamines (NAEs), like oleoylethanolamide (OEA), activate GPR119, and multiple synthetic ligands have been described. Here, we extend the GPR119 signaling profile to Gαq and Gαi in addition to β-arrestin recruitment and the downstream transcription factors CRE (cAMP response element), SRE (serum response element) and NFAT (nuclear factor of activated T cells)...
November 1, 2016: Biochemical Pharmacology
Jamil Al-Swiahb, Shi Nae Park
OBJECTIVES: The aim of this study was to characterize tinnitus in affected patients. METHODS: A retrospective review of medical records from 470 consecutive patients who visited a tertiary care hospital for evaluation of chronic subjective tinnitus between January 2009 and June 2010 was performed. Patients were divided into three subgroups based on age. Clinical, audiological, and psychological characteristics of each subgroup were analyzed. RESULTS: Of the 470 patients evaluated, 85 were less than 40, 217 between 40 and 60, and 168 above 60 years of age...
July 2016: Noise & Health
Nae-Fang Twu, Yu-Che Ou, Cheng-I Liao, Wei-Yang Chang, Lan-Yan Yang, Yun-Hsin Tang, Tze-Chien Chen, Chi-Hau Chen, Tze-Ho Chen, Lain-Shung Yeh, Shih-Tien Hsu, Yu-Chieh Chen, Cheng-Chang Chang, Ya-Min Cheng, Chia-Yen Huang, Fu-Shing Liu, Yue-Shan Lin, Sheng-Mou Hsiao, Yuan-Yee Kan, Chyong-Huey Lai
OBJECTIVE: We aimed to identify prognostic factors of early-stage cervical adenocarcinoma (AC) and adenosquamous carcinoma (ASC) treated with primary radical surgery, and to evaluate the impact of postoperative adjuvant therapy on outcome. METHODS: The clinical-pathological data of all patients (n = 1132) with stages I-II cervical AC/ASC treated with primary radical surgery at the member hospitals of the Taiwanese Gynecologic Oncology Group were retrospectively reviewed...
September 2016: Surgical Oncology
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