keyword
https://read.qxmd.com/read/38518830/er-organelle-contacts-a-signaling-hub-for-neurological-diseases
#21
REVIEW
Yunli Wang, Jinghua Yang
Neuronal health is closely linked to the homeostasis of intracellular organelles, and organelle dysfunction affects the pathological progression of neurological diseases. In contrast to isolated cellular compartments, a growing number of studies have found that organelles are largely interdependent structures capable of communicating through membrane contact sites (MCSs). MCSs have been identified as key pathways mediating inter-organelle communication crosstalk in neurons, and their alterations have been linked to neurological disease pathology...
March 20, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/38518038/long-covid-s-impact-on-patients-workers-society-a-review
#22
JOURNAL ARTICLE
Kevin T Kavanagh, Lindsay E Cormier, Christine Pontus, Aaron Bergman, Wilmore Webley
The incidence of long COVID in adult survivors of an acute SARS-CoV-2 infection is approximately 11%. Of those afflicted, 26% have difficulty with day-to-day activities. The majority of long COIVD cases occur after mild or asymptomatic acute infection. Children can spread SARS-CoV-2 infections and can also develop long-term neurological, endocrine (type I diabetes), and immunological sequelae. Immunological hypofunction is exemplified by the recent large outbreaks of respiratory syncytial virus and streptococcal infections...
March 22, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38517401/moving-forward-with-pain-an-interview-with-john-d-loeser
#23
JOURNAL ARTICLE
John D Loeser
John D Loeser speaks to Thomas York, Journal Development Editor of Pain Management . John D Loeser is Professor, emeritus, of Neurological Surgery and Anesthesiology and Pain Medicine at the University of Washington where he has been a faculty member since 1969. He was the Director of the Multidisciplinary Pain Center at the University of Washington from 1983 to 1997. He has been active in research, teaching and patient care in the field of Pain Management for over 45 years. He was a founding member and served as president of the American Pain Society and the International Association for the Study of Pain...
March 22, 2024: Pain Management
https://read.qxmd.com/read/38516830/consciousness-how-our-brains-turn-matter-into-meaning
#24
JOURNAL ARTICLE
Howard S Kirshner
No abstract text is available yet for this article.
March 22, 2024: Cognitive and Behavioral Neurology: Official Journal of the Society for Behavioral and Cognitive Neurology
https://read.qxmd.com/read/38514517/reflections-upon-the-intrauterine-repair-of-myelomeningocele
#25
REVIEW
Giuseppe Talamonti
The intrauterine repair of myelomeningocele presents certain advantages and has gained widespread acceptance. It significantly reduces the incidence of Chiari-2 anomalies and hydrocephalus, and it is thought to enhance the neurologic outcome. Nevertheless, several issues remain unsettled and there are no negligible disadvantages. After working with patients with myelomeningocele for 30 years, I thought about how we currently treat them. There are ethical, organizational, neurological, obstetrical, and postnatal aspects worth discussing...
March 22, 2024: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://read.qxmd.com/read/38514134/-japanese-national-plan-for-promotion-of-measures-against-stroke-and-cardiovascular-diseases-and-data-based-health-management-initiatives
#26
JOURNAL ARTICLE
Koji Iihara
This review outlines the recent advances in stroke and cardiovascular diseases control and direction of national data health reform. Since the enactment of the Basic Act on Countermeasures against Cardiovascular Diseases, the national government and related academic societies have collaborated to promote countermeasures based on five key pillars; medical systems development, registration projects promotion, human resource development, public awareness, and research promotion. Simultaneously, the government is intensively promoting data health reform to compensate for the delay in digital medicine that became evident in the new coronary infection...
March 2024: No Shinkei Geka. Neurological Surgery
https://read.qxmd.com/read/38513996/diagnosing-schizophrenia-using-deep-learning-novel-interpretation-approaches-and-multi-site-validation
#27
JOURNAL ARTICLE
Tingting Weng, Yuemei Zheng, Yingying Xie, Wen Qin, Li Guo
Schizophrenia is a profound and enduring mental disorder that imposes significant negative impacts on individuals, their families, and society at large. The development of more accurate and objective diagnostic tools for schizophrenia can be expedited through the employment of deep learning (DL), that excels at deciphering complex hierarchical non-linear patterns. However, the limited interpretability of deep learning has eroded confidence in the model and restricted its clinical utility. At the same time, if the data source is only derived from a single center, the model's generalizability is difficult to test...
March 19, 2024: Brain Research
https://read.qxmd.com/read/38512419/epidemiologic-analysis-and-mortality-outcome-of-firearm-injuries-in-french-guiana-2016-2019
#28
JOURNAL ARTICLE
Alexis Fremery, Elliott Beguinot, Angélique Franchi, Mathilde Douchet, Victor Tertre, Karim Hamiche, Antoine Adenis, Jean Marc Pujo, Hatem Kallel
BACKGROUND: French Guiana (FG) is a French territory located in South America with the highest rate of armed assaults. FG presents a poorly developed road system and a young and precarious population that makes the geographical and socio-demographic characteristics specific. No data concerning the firearm injury management are available in this country. Studying thesis trauma could permit to improve the management of victims. The objective of this study is to investigate the epidemiology of firearm injuries in FG, to define characteristics of the victims, and to assess factors associated with death...
March 21, 2024: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://read.qxmd.com/read/38511878/rate-and-characteristics-of-inflammatory-neuropathies-associated-with-brentuximab-vedotin-therapy
#29
JOURNAL ARTICLE
Arthur Matthys, Benjamin Bardel, Fabien Le Bras, Alain Créange, Tarik Nordine, Romain Gounot, Saskia Ingen-Housz-Oro, Muriel Carvalho, Jean-Pascal Lefaucheur, Corinne Haioun, Violaine Planté-Bordeneuve, Thierry Gendre
BACKGROUND AND PURPOSE: Peripheral neuropathy is a frequent complication of brentuximab vedotin (BV), used in CD30+ lymphoma treatment. Classic BV-induced neuropathy (BV-CN) is a mild distal sensory axonal polyneuropathy. Severe BV-induced inflammatory neuropathies (BV-IN) have been described. BV-IN contribute to lymphoma-associated morbidity but might be immunotherapy-responsive. Our primary objective was to evaluate the rate of BV-IN. Our secondary objectives were to determine risk factors and warning signs...
March 21, 2024: European Journal of Neurology
https://read.qxmd.com/read/38510224/methadone-for-emergence-delirium-in-ambulatory-pediatric-strabismus-surgery
#30
JOURNAL ARTICLE
Khaled A Dajani, Bren Davis, Hussam Ghabra, Jakayla Harrell-Mohamed, Carol O Carrillo, H Sprague Eustis
Background: Emergence delirium in children following strabismus surgery is a distressing and potentially dangerous condition and is likely attributable to visual disturbances, pain, and anesthetic gases. We explored whether a single intraoperative dose of methadone could reduce emergence delirium. Methods: Our study was an institutional review board-approved prospective, controlled, before-and-after investigation. Inclusion criteria were age <18 years and American Society of Anesthesiologists (ASA) classification 1 or 2...
2024: Ochsner Journal
https://read.qxmd.com/read/38508838/genetics-of-migraine-complexity-implications-and-potential-clinical-applications
#31
REVIEW
Heidi G Sutherland, Bronwyn Jenkins, Lyn R Griffiths
Migraine is a common neurological disorder with large burden in terms of disability for individuals and costs for society. Accurate diagnosis and effective treatments remain priorities. Understanding the genetic factors that contribute to migraine risk and symptom manifestation could improve individual management. Migraine has a strong genetic basis that includes both monogenic and polygenic forms. Some distinct, rare, familial migraine subtypes are caused by pathogenic variants in genes involved in ion transport and neurotransmitter release, suggesting an underlying vulnerability of the excitatory-inhibitory balance in the brain, which might be exacerbated by disruption of homoeostasis and lead to migraine...
April 2024: Lancet Neurology
https://read.qxmd.com/read/38508626/evidence-informed-and-consensus-based-statements-about-safety-of-physical-agent-modalities-practice-in-physiotherapy-and-rehabilitation-medicine-safe-pamp-a-national-delphi-of-healthcare-scientific-societies
#32
JOURNAL ARTICLE
Silvia Gianola, Silvia Bargeri, Leonardo Pellicciari, Simone Gambazza, Giacomo Rossettini, Anna Fulvio, Vincenzo Genovese, Matteo Benedini, Emanuele Proverbio, Simone Cecchetto, Greta Castellini, Andrea Turolla
OBJECTIVE: A shared consensus on the safety about physical agent modalities (PAMs) practice in physiotherapy and rehabilitation is lacking. We aimed to develop evidence-informed and consensus-based statements about the safety of PAMs. STUDY DESIGN AND SETTING: A RAND-modified Delphi Rounds' survey was used to reach a consensus. We established a steering committee of the Italian Association of Physiotherapy (Associazione Italiana di Fisioterapia) to identify areas and questions for developing statements about the safety of the most commonly used PAMs in physiotherapy and rehabilitation...
March 19, 2024: BMJ Open
https://read.qxmd.com/read/38508018/familial-occurrence-of-seizure-disorders-across-mri-defined-structural-focal-epilepsy-etiology
#33
JOURNAL ARTICLE
Maša Kovačević, Dragoslav Sokić, Aleksandar Ristić, Ivana Berisavac, Marko Ercegovac, Ognjen Milićević, Nikola Vojvodić
BACKGROUND: Previous studies have established familial occurrence of epilepsy and seizure disorders and early age of epilepsy onset as predictors of genetic epilepsy, but have not evaluated the rate of their occurrence in patients with different epilepsy etiology. Our study determines the distribution of familial occurrence and age of epilepsy onset across structural focal epilepsy (FE) etiology in a large FE cohort. METHODS: Records of 1354 consecutive patients evaluated for epilepsy and seizure disorders in The Neurology Clinic, University Clinical Center of Serbia from 2008 to 2019 were screened for FE...
March 19, 2024: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://read.qxmd.com/read/38507913/the-first-deep-rebreather-dive-using-hydrogen-case-report
#34
Richard J Harris, Craig J Challen, Simon J Mitchell
Bounce diving with rapid descents to very deep depths may provoke the high-pressure neurological syndrome (HPNS). The strategy of including small fractions of nitrogen in the respired gas to produce an anti-HPNS narcotic effect increases the gas density which may exceed recommended guidelines. In 2020 the 'Wetmules' dive team explored the Pearse Resurgence cave (New Zealand) to 245 m breathing trimix (approximately 4% oxygen, 91% helium and 5% nitrogen). Despite the presence of nitrogen, one diver experienced HPNS tremors beyond 200 m...
March 31, 2024: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
https://read.qxmd.com/read/38507912/hyperbaric-oxygen-for-the-treatment-of-carbon-monoxide-induced-delayed-neurological-sequelae-a-case-report-and-review-of-the-literature
#35
REVIEW
Zebedee Kr Wong, Colin Ka Teo, James Wm Kwek, Soo Joang Kim, Hooi Geok See
INTRODUCTION: Hyperbaric oxygen treatment (HBOT) remains a recognised treatment for acute carbon monoxide (CO) poisoning, but the utility of HBOT in treating CO-induced delayed neurological sequelae (DNS) is not yet established. CASE DESCRIPTION: A 26-year old woman presented with reduced consciousness secondary to CO exposure from burning charcoal. She underwent a single session of HBOT with US Navy Treatment Table 5 within six hours of presentation, with full neurological recovery...
March 31, 2024: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
https://read.qxmd.com/read/38507911/secondary-deterioration-in-a-patient-with-cerebral-and-coronary-arterial-gas-embolism-after-brief-symptom-resolution-a-case-report
#36
Ryota Tsushima, Kosuke Mori, Shohei Imaki
INTRODUCTION: Hyperbaric oxygen treatment (HBOT) is recommended for arterial gas embolism (AGE) with severe symptoms. However, once symptoms subside, there may be a dilemma to treat or not. CASE PRESENTATION: A 71-year-old man was noted to have a mass shadow in his left lung, and a transbronchial biopsy was performed with sedation. Flumazenil was intravenously administered at the end of the procedure. However, the patient remained comatose and developed bradycardia, hypotension, and ST-segment elevation in lead II...
March 31, 2024: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
https://read.qxmd.com/read/38506427/occupational-performance-one-to-five-years-after-aneurysmal-subarachnoid-haemorrhage-a-cohort-study
#37
JOURNAL ARTICLE
Marcus Kessner, Jan Mehrholz, Svein Harald Mørkve, Tina Taule
OBJECTIVE: To report on the self-perceived occupational performance of patients with aneurysmal subarachnoid haemorrhage and examine the associations between aneurysmal subarachnoid haemorrhage characteristics, socio-demographic factors and self-perceived problems. DESIGN: A single-centre cohort study design was combined with a cross-sectional analysis. SUBJECTS/PATIENTS: All patients with aneurysmal subarachnoid haemorrhage who were capable of performing activities of daily living before discharge from hospital were included...
March 20, 2024: Journal of Rehabilitation Medicine
https://read.qxmd.com/read/38503711/post-stroke-emotionalism-diagnosis-pathophysiology-and-treatment
#38
JOURNAL ARTICLE
Niall Broomfield, Joshua Blake, Fergus Gracey, Tom Steverson
Post-stroke emotionalism affects 1 in 5 stroke sufferers 6 months after their stroke, but despite its frequency remains a poorly understood stroke symptom. The literature is limited, especially compared to other frequently observed neurological conditions such as aphasia and visual neglect. This narrative review presents a summary of this literature, to inform clinical practice and future research. We cover discussion of definitions, prevalence, neurobiology, predisposing and precipitating factors, and treatment...
March 19, 2024: International Journal of Stroke: Official Journal of the International Stroke Society
https://read.qxmd.com/read/38502219/the-increasing-burden-of-emergency-department-and-inpatient-consultations-for-papilledema
#39
JOURNAL ARTICLE
Hetal J Ray, Avital Lily Okrent Smolar, Michael Dattilo, Walid Bouthour, Gabriele Berman, Jason H Peragallo, Sachin Kedar, Andrew M Pendley, James G Greene, Matthew T Keadey, David W Wright, Beau B Bruce, Nancy J Newman, Valérie Biousse
BACKGROUND: Increasing incidence of idiopathic intracranial hypertension (IIH), overreported radiologic signs of intracranial hypertension, difficult access to outpatient neuro-ophthalmology services, poor insurance coverage, and medicolegal concerns have lowered the threshold for emergency department (ED) visits for "papilledema." Our objective was to examine referral patterns and outcomes of neuro-ophthalmology ED and inpatient consultations for concern for papilledema. METHODS: At one university-based quaternary care center, all adults referred for "papilledema" over one year underwent a standardized ED "papilledema protocol...
March 19, 2024: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://read.qxmd.com/read/38502216/photostress-induced-uhthoff-phenomenon
#40
JOURNAL ARTICLE
Janet S Sunness, Olwen Murphy, Peter Calabresi
No abstract text is available yet for this article.
March 19, 2024: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
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