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https://www.readbyqxmd.com/read/28328129/the-phenotypic-spectrum-of-congenital-zika-syndrome
#1
Miguel Del Campo, Ian M L Feitosa, Erlane M Ribeiro, Dafne D G Horovitz, André L S Pessoa, Giovanny V A França, Alfredo García-Alix, Maria J R Doriqui, Hector Y C Wanderley, Maria V T Sanseverino, João I C F Neri, João M Pina-Neto, Emerson S Santos, Islane Verçosa, Mirlene C S P Cernach, Paula F V Medeiros, Saile C Kerbage, André A Silva, Vanessa van der Linden, Celina M T Martelli, Marli T Cordeiro, Rafael Dhalia, Fernanda S L Vianna, Cesar G Victora, Denise P Cavalcanti, Lavinia Schuler-Faccini
In October 2015, Zika virus (ZIKV) outbreak the Brazilian Ministry of Health (MoH). In response, the Brazilian Society of Medical Genetics established a task force (SBGM-ZETF) to study the phenotype of infants born with microcephaly due to ZIKV congenital infection and delineate the phenotypic spectrum of this newly recognized teratogen. This study was based on the clinical evaluation and neuroimaging of 83 infants born during the period from July, 2015 to March, 2016 and registered by the SBGM-ZETF. All 83 infants had significant findings on neuroimaging consistent with ZIKV congenital infection and 12 had confirmed ZIKV IgM in CSF...
April 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28327912/long-term-neurological-outcome-and-quality-of-life-after-world-federation-of-neurosurgical-societies-grades-iv-and-v-aneurysmal-subarachnoid-hemorrhage-in-an-interdisciplinary-treatment-concept
#2
Christoph Schwartz, Thomas Pfefferkorn, Caroline Ebrahimi, Caroline Ottomeyer, Gunther Fesl, Andreas Bender, Andreas Straube, Hans-Walter Pfister, Suzette Heck, Jörg-Christian Tonn, Christian Schichor
BACKGROUND: Detailed data on long-term functional outcome of patients with World Federation of Neurosurgical Societies (WFNS) grades IV and V aneurysmal subarachnoid hemorrhages (aSAH) are still scarce. OBJECTIVE: Assessment of long-term outcome of WFNS IV and V aSAH patients. METHODS: Functional outcome and quality of life were assessed by the modified Rankin scale (mRS) and the 36-item short-form health survey in consecutively treated aSAH WFNS IV and V patients between 2005 and 2010...
February 2, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28322240/international-spinal-cord-injury-endocrine-and-metabolic-extended-data-set
#3
W A Bauman, J M Wecht, F Biering-Sørensen
OBJECTIVE: The objective of this study was to develop the International Spinal Cord Injury (SCI) Endocrine and Metabolic Extended Data Set (ISCIEMEDS) within the framework of the International SCI Data Sets that would facilitate consistent collection and reporting of endocrine and metabolic findings in the SCI population. SETTING: This study was conducted in an international setting. METHODS: The ISCIEMEDS was developed by a working group...
March 21, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28299469/comparative-evaluation-of-h-h-and-wfns-grading-scales-with-modified-h-h-sans-systemic-disease-a-study-on-1000-patients-with-subarachnoid-hemorrhage
#4
Ashish Aggarwal, Sivashanmugam Dhandapani, Kokkula Praneeth, Harsimrat Bir Singh Sodhi, Sudhir Singh Pal, Sachin Gaudihalli, N Khandelwal, Kanchan K Mukherjee, M K Tewari, Sunil Kumar Gupta, S N Mathuriya
The comparative studies on grading in subarachnoid hemorrhage (SAH) had several limitations such as the unclear grading of Glasgow Coma Scale 15 with neurological deficits in World Federation of Neurosurgical Societies (WFNS), and the inclusion of systemic disease in Hunt and Hess (H&H) scales. Their differential incremental impacts and optimum cut-off values for unfavourable outcome are unsettled. This is a prospective comparison of prognostic impacts of grading schemes to address these issues. SAH patients were assessed using WFNS, H&H (including systemic disease), modified H&H (sans systemic disease) and followed up with Glasgow Outcome Score (GOS) at 3 months...
March 15, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/28298756/comparison-of-postoperative-pain-after-epidural-anesthesia-using-0-5-0-75-ropivacaine-and-0-5-bupivacaine-in-patients-undergoing-lower-limb-surgery-a-double-blind-study
#5
Tripat Kaur Bindra, Rajvinder Singh, Ruchi Gupta
BACKGROUND: Ropivacaine (S (-)-1-propyl-2", 6"; pipecoloxylidide hydrochloride) a newer long-acting amide local anesthetic has various clinical and pharmacokinetic advantages over bupivacaine. AIMS: The aim of this study is to compare the onset as well as the duration of sensory block, hemodynamic variables, and postoperative analgesia with 0.5%, 0.75% ropivacaine and 0.5% bupivacaine after epidural anesthesia for lower limb orthopedic surgery. PATIENTS AND METHODS: Sixty American Society of Anesthesiologists I and II patients scheduled for lower limb orthopedic surgery were enrolled into this randomized, double-blind study...
January 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/28292398/-french-society-of-neurology-award-excellence-in-neurology-2016
#6
EDITORIAL
G Edan
No abstract text is available yet for this article.
March 2017: Revue Neurologique
https://www.readbyqxmd.com/read/28291402/complication-rates-associated-with-3-column-osteotomy-in-82-adult-spinal-deformity-patients-retrospective-review-of-a-prospectively-collected-multicenter-consecutive-series-with-2-year-follow-up
#7
Justin S Smith, Christopher I Shaffrey, Eric Klineberg, Virginie Lafage, Frank Schwab, Renaud Lafage, Han Jo Kim, Richard Hostin, Gregory M Mundis, Munish Gupta, Barthelemy Liabaud, Justin K Scheer, Bassel G Diebo, Themistocles S Protopsaltis, Michael P Kelly, Vedat Deviren, Robert Hart, Doug Burton, Shay Bess, Christopher P Ames
OBJECTIVE Although 3-column osteotomy (3CO) can provide powerful alignment correction in adult spinal deformity (ASD), these procedures are complex and associated with high complication rates. The authors' objective was to assess complications associated with ASD surgery that included 3CO based on a prospectively collected multicenter database. METHODS This study is a retrospective review of a prospectively collected multicenter consecutive case registry. ASD patients treated with 3CO and eligible for 2-year follow-up were identified from a prospectively collected multicenter ASD database...
February 17, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28287895/proceedings-of-the-2017-spring-meeting-of-the-society-of-british-neurological-surgeons
#8
(no author information available yet)
No abstract text is available yet for this article.
April 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/28286275/spontaneous-pyogenic-spondylodiscitis-in-the-thoracic-or-lumbar-spine-a-retrospective-cohort-study-comparing-the-safety-and-efficacy-of-minimally-invasive-and-open-surgery-over-a-nine-year-period
#9
Lennart Viezens, Christian Schaefer, Rachel Helmers, Eik Vettorazzi, Malte Schroeder, Nils Hansen-Algenstaedt
PURPOSE: Pyogenic spondylodiscitis is a rare disease, but its incidence is increasing. Over the last decade, spinal surgery has been modified to become minimally invasive. In degenerative spinal disorders, such minimally invasive surgery (MIS) reduces blood loss, muscular trauma and the hospital stay. However, it is not known whether MIS also confers these benefits to patients with pyogenic spondylodiscitis. This retrospective cohort study compared the safety and efficacy of minimally invasive surgery (MIS) and the conventional open surgical procedure in patients with pyogenic spondylodiscitis...
March 9, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28283963/the-application-of-proteomics-to-traumatic-brain-and-spinal-cord-injuries
#10
REVIEW
George Anis Sarkis, Manasi D Mangaonkar, Ahmed Moghieb, Brian Lelling, Michael Guertin, Hamad Yadikar, Zhihui Yang, Firas Kobeissy, Kevin K W Wang
Traumatic brain injury (TBI) and traumatic spinal cord injury (SCI), collectively termed neurotrauma, are two parallel neurological conditions that can cause long-lasting neurological impairment and other comorbidities in patients, while at the same time, can create a high burden to society. To date, there are still no FDA-approved therapeutic interventions for either TBI or SCI. Recent advances in proteomic technologies, including tandem mass spectrometry, as well as imaging mass spectrometry, have enabled new approaches to study the differential proteome in TBI and SCI with the use of either animal disease models and/or biosamples from clinical observational studies...
March 2017: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/28282665/honorary-award-of-the-german-speaking-society-of-child-neurology-for-the-year-2016-gesellschaft-f%C3%A3-r-neurop%C3%A3-diatrie-for-ingeborg-sophie-kr%C3%A3-geloh-mann
#11
https://www.readbyqxmd.com/read/28281490/evidence-based-guidelines-for-the-management-of-epilepsy
#12
REVIEW
Sanjay P Singh, Ram Sankaraneni, Arun R Antony
Approximately 50 million people live with epilepsy worldwide. The aim of this review is to present an overview of the current evidence and management recommendations for evaluation and treatment of patients with epilepsy. Systematic literature reviews were undertaken. A review of contemporary published evidence-based guidelines (American Academy of Neurology, American Epilepsy Society, and the Indian Epilepsy Society) and published peer reviewed scientific publications was done. The guideline is addressed to all clinicians who manage epilepsy patients...
2017: Neurology India
https://www.readbyqxmd.com/read/28279774/conscious-sedation-versus-general-anesthesia-for-the-treatment-of-cerebral-aneurysms-with-flow-diversion-a-matched-cohort-study
#13
Christoph J Griessenauer, Hussain Shallwani, Nimer Adeeb, Raghav Gupta, Leonardo Rangel-Castilla, Adnan H Siddiqui, Elad I Levy, Myles D Boone, Ajith J Thomas, Christopher S Ogilvy
INTRODUCTION: Flow diversion has become a popular treatment option for a variety of cerebral aneurysms. We sought to compare conscious sedation and general anesthesia for flow diverter placement in a matched cohort study. MATERIALS AND METHODS: Patients who underwent flow diverter placement under conscious sedation were matched on the basis of age, sex, American Society of Anesthesiologists (ASA) classification, aneurysm location, and aneurysm size with patients who received general anesthesia...
March 6, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28274022/use-of-dexmedetomidine-in-patients-undergoing-craniotomies
#14
Nalini Jadhav, Nilesh Wasekar, Vinayak Wagaskar, Bharati Kondwilkar, Rajesh Patil
INTRODUCTION: The neuroanaesthesia ensures stable perioperative cerebral haemodynamics, avoids sudden rise in intracranial pressure and prevents acute brain swelling. The clinical characteristics of dexmeditomidine make this intravenous agent a potentially attractive adjunct for neuroanaesthesia and in the neurological intensive care unit. AIM: This study aimed to assess the effect of dexmedetomidine on intraoperative haemodynamic stability and to assess the intraoperative requirements of analgesic and other anaesthetic agents, and also to assess postoperative sedation, respiratory depression and any other side effects of dexmedetomidine as compared to placebo...
January 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28273039/multiple-sclerosis-in-canada-2011-to-2031-results-of-a-microsimulation-modelling-study-of-epidemiological-and-economic-impacts
#15
Nana Amankwah, Ruth Ann Marrie, Christina Bancej, Rochelle Garner, Douglas G Manuel, Ron Wall, Philippe Finès, Julie Bernier, Karen Tu, Kim Reimer
INTRODUCTION: The objective of our study was to present model-based estimates and projections on current and future health and economic impacts of multiple sclerosis (MS) in Canada over a 20-year time horizon (2011-2031). METHODS: Using Statistics Canada's Population Health Microsimulation Model (POHEM) framework, specifically the population-based longitudinal, microsimulation model named POHEM-Neurological, we identified people with MS from health administrative data sources and derived incidence and mortality rate parameters from a British Columbia population-based cohort for future MS incidence and mortality projections...
February 2017: Health Promotion and Chronic Disease Prevention in Canada
https://www.readbyqxmd.com/read/28267937/patient-and-procedural-factors-associated-with-an-increased-risk-of-harm-or-death-in-the-first-4-000-incidents-reported-to-webairs
#16
N M Gibbs, M D Culwick, A F Merry
This report describes an analysis of patient and procedural factors associated with a higher proportion of harm or death versus no harm in the first 4,000 incidents reported to webAIRS. The report is supplementary to a previous cross-sectional report on the first 4,000 incidents reported to webAIRS. The aim of this analysis was to identify potential patient or procedural factors that are more common in incidents resulting in harm or death than in incidents with more benign outcomes. There was a >50% higher proportion of harm (versus no harm) for incidents in which the patient's body mass index (BMI) was <18...
March 2017: Anaesthesia and Intensive Care
https://www.readbyqxmd.com/read/28266950/postoperative-analgesia-after-wound-infiltration-with-tramadol-and-dexmedetomidine-as-an-adjuvant-to-ropivacaine-for-lumbar-discectomies-a-randomized-controlled-clinical-trial
#17
Saikat Mitra, Shobha Purohit, Mamta Sharma
INTRODUCTION: Crippling postoperative pain linked with lumbar discectomies not only shackles patient's normal daily activities but also lengthens their hospital stay. So, allaying postoperative pain in these patients has become a substantive component in neuroanesthesia to expedite neurological recovery. Wound infiltration with local anesthetics is widely used to optimize postoperative pain. Different adjuvants like dexmedetomidine and tramadol when added to local anesthetics prolongs postoperative analgesia...
March 6, 2017: Journal of Neurosurgical Anesthesiology
https://www.readbyqxmd.com/read/28260956/in-flight-medical-emergencies-during-airline-operations-a-survey-of-physicians-on-the-incidence-nature-and-available-medical-equipment
#18
Jochen Hinkelbein, Christopher Neuhaus, Lennert Böhm, Steffen Kalina, Stefan Braunecker
BACKGROUND: Data on the incidence of in-flight medical emergencies on-board civil aircraft are uncommon and rarely published. Such data could provide information regarding required medical equipment on-board aircraft and requisite training for cabin crew. The aim of the present study was to gather data on the incidences, nature, and medical equipment for in-flight medical emergencies by way of a survey of physician members of a German aerospace medical society. MATERIALS AND METHODS: Using unipark...
2017: Open Access Emergency Medicine: OAEM
https://www.readbyqxmd.com/read/28259574/a-comparison-of-results-of-carotid-endarterectomy-in-octogenarians-and-nonagenarians-to-younger-patients-from-the-mid-america-vascular-study-group-and-the-society-for-vascular-surgery-vascular-quality-initiative
#19
Joseph R Schneider, Cheryl R Jackson, Irene B Helenowski, Michael J Verta, Julia B Wilkinson, Stanley Kim, Andrew W Hoel
OBJECTIVE: Carotid endarterectomy (CEA) reduces stroke risk in selected patients. However, CEA risk profile may be different in older patients. We compared characteristics and outcomes of octogenarians and nonagenarians with those of younger patients. METHODS: Deidentified data from CEA patients were obtained from the Society for Vascular Surgery Vascular Quality Initiative (VQI) database. Prior CEA, carotid artery stent, or combined CEA and coronary artery bypass were excluded, yielding 7390 CEAs in octogenarians and nonagenarians (≥80 years of age) and 35,303 CEAs in younger patients (<80 years of age)...
March 1, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28259266/predictors-of-health-related-quality-of-life-after-complex-adult-spinal-deformity-surgery-a-scoli-risk-1-secondary-analysis
#20
Leah Y Carreon, Steven D Glassman, Christopher I Shaffrey, Michael G Fehlings, Benny Dahl, Christopher P Ames, Yukihiro Matsuyama, Yong Qiu, Hossein Mehdian, Kenneth M C Cheung, Frank J Schwab, Ferran Pellisé, Khaled M Kebaish, Lawrence G Lenke
STUDY DESIGN: Longitudinal cohort. OBJECTIVES: To identify variables that predict 2-year Short Form-36 Physical Composite Summary Score (SF-36PCS) and the Scoliosis Research Society-22R (SRS22-R) Total score after surgery for complex adult spinal deformity. SUMMARY OF BACKGROUND DATA: Increasingly, treatment effectiveness is assessed by the extent to which the procedure improves a patient's health-related quality of life (HRQOL). This is especially true in patients with complex adult spinal deformity...
March 2017: Spine Deformity
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