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https://www.readbyqxmd.com/read/28230038/association-between-hepatitis-b-virus-hepatitis-c-virus-infection-and-primary-hepatocellular-carcinoma-risk-a-meta-analysis-based-on-chinese-population
#1
Libo Li, Xiaolin Lan
OBJECTIVE: To assess the relationship between hepatitis B virus (HBV), hepatitis C virus (HCV), and HBV/HCV double infection and hepatocellular carcinoma risk in Chinese population. MATERIALS AND METHODS: The databases of PubMed and CNKI were electronic searched by reviewers according to the searching words of HBV, HCV, and hepatocellular carcinoma. The related case-control studies or cohort studies were included. The association between virus infection and hepatocellular carcinoma risk was demonstrated by odds ratio (OR) and 95% confidence interval (95% CI)...
December 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28230035/a-meta-analysis-of-contrast-enhanced-ultrasound-for-small-hepatocellular-carcinoma-diagnosis
#2
Huadong Deng, Hongwei Shi, Jianming Lei, Yan Hu, Gang Li, Chaojun Wang
OBJECTIVE: To discuss the efficacy of contrast-enhanced ultrasound (CEUS) for diagnosis of small hepatocellular carcinoma (HCC) by pooling the open published data. METHODS: A comprehensive publication electronic search was performed by reviewers in the databases of PubMed, Embase, Web of Science, and China National Knowledge Infrastructure. The open published studies about CEUS for small HCC diagnosis were collected. The sensitivity, specificity, positive likelihood ratio (+LR), negative likelihood ratio (-LR), and diagnostic odds ratio (DOR) were pooled by stata 12...
December 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28220382/meta-analysis-of-laparoscopic-vs-open-liver-resection-for-hepatocellular-carcinoma
#3
Georgios C Sotiropoulos, Anastasia Prodromidou, Ioannis D Kostakis, Nikolaos Machairas
Laparoscopic liver resections (LLR) are widely accepted as safe and effective procedures for the management of hepatocellular carcinoma (HCC) in the hands of experienced surgeons. The efficacy and extent of benefits of pure as well as hand-assisted laparoscopic and laparoscopy-assisted liver resection over open liver resection (OLR) have been investigated by numerous studies during the last 10 years. The aim of our meta-analysis is to investigate the effect of LLR in short- and long-term outcomes compared to OLR in patients operated for HCC...
February 20, 2017: Updates in Surgery
https://www.readbyqxmd.com/read/28215616/incidence-and-determinants-of-hepatocellular-carcinoma-in-autoimmune-hepatitis-a-systematic-review-and-meta-analysis
#4
REVIEW
Aylin Tansel, Lior H Katz, Hashem B El-Serag, Aaron P Thrift, Mayur Parepally, Mohammad H Shakhatreh, Fasiha Kanwal
BACKGROUND: The risk of hepatocellular carcinoma (HCC) in patients with autoimmune hepatitis (AIH) is unclear. We conducted a systematic review and meta-analysis of the incidence of HCC and associated risk factors among patients with AIH. METHODS: We searched PubMed, Embase, and reference lists from relevant articles through June 2016 to identify cohort studies that examined the incidence of HCC in patients with AIH. We used random effects models to estimate pooled incidence rates overall and in subgroup of patients with cirrhosis...
February 12, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28206965/prognostic-role-of-platelet-to-lymphocyte-ratio-in-hepatocellular-carcinoma-a-systematic-review-and-meta-analysis
#5
Yongzhao Zhao, Guangyan Si, Fengshang Zhu, Jialiang Hui, Shangli Cai, Chenshen Huang, Sijin Cheng, Abdel Hamid Fathy, Yi Xiang, Jing Li
BACKGROUND AND AIMS: Several studies were conducted to explore the prognostic significance of platelet to lymphocyte ratio (PLR) in hepatocellular carcinoma (HCC), however, contradictory results across most reports were documented. To this end, we present a systematic review that aims to summarize the prognostic significance of PLR in patients with HCC. RESULTS: A total of 10 studies involving a total of 2,315 patients were identified. The Newcastle-Ottawa Quality Assessment Scale (NOS) of each included study was greater than or equal to 5...
February 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28202430/vespro-an-individual-patient-data-prospective-meta-analysis-of-selective-internal-radiation-therapy-versus-sorafenib-for-advanced-locally-advanced-or-recurrent-hepatocellular-carcinoma-of-the-sarah-and-sirvenib-trials
#6
Val Gebski, Emma Gibbs, Mihir Gandhi, Gilles Chatellier, Aurelia Dinut, Helena Pereira, Pierce Kh Chow, Valérie Vilgrain
BACKGROUND: Untreated advanced hepatocellular carcinoma (HCC) has an overall poor prognosis. Currently there are 2 ongoing prospective randomized controlled trials that are evaluating the efficacy and safety of sorafenib and selective internal radiation therapy (SIRT) with yttrium-90 resin microspheres in patients with advanced HCC. The SorAfenib versus Radioembolisation in Advanced Hepatocellular carcinoma (SARAH; 459 patients) trial is being performed in Europe and the SIRt VErsus SorafeNIB (SIRveNIB; 360 patients) trial in the Asia Pacific region...
February 15, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28188488/long-noncoding-rnas-as-novel-serum-biomarkers-for-the-diagnosis-of-hepatocellular-carcinoma-a-systematic-review-and-meta-analysis
#7
C Zheng, H Hao, L Chen, J Shao
PURPOSE: Long noncoding RNAs (lncRNAs) are outstanding as novel cancer biomarkers with great prospects. Herein, we focused on summarizing the overall diagnostic evaluation of lncRNAs for hepatocellular carcinoma (HCC). METHODS: Relevant literature was collected from the online databases. The Quality Assessment for Studies of Diagnostic Accuracy checklist was used to assess the quality of included studies. The pooled sensitivity, specificity, and diagnostic odds ratio (DOR) were plotted using random-effects models...
February 10, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28188097/study-of-the-association-between-five-polymorphisms-and-risk-of-hepatocellular-carcinoma-a-meta-analysis
#8
Jia-Yun Yu, Fan Hu, Wei Du, Xue-Lei Ma, Kun Yuan
BACKGROUND: Recently, several studies have investigated the association between polymorphisms in miR-146a rs2910164, miR-196a2 rs11614913, miR-499 rs3746444, miR-149 rs229283, miR-34b/c rs4938723, and hepatocellular carcinoma (HCC), which showed inconclusive results. METHODS: A publication search was performed in PubMed, ExcerptaMedica Database, Chinese Biomedical Literature Database, and Chinese National Knowledge Infrastructure to collect relevant medical data published through February 2016...
February 7, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/28177886/transarterial-chemoembolization-tace-combined-with-sorafenib-versus-tace-for-hepatocellular-carcinoma-with-portal-vein-tumor-thrombus-a-systematic-review-and-meta-analysis
#9
XiuPing Zhang, Kang Wang, Meng Wang, Guang Yang, XiaoFei Ye, MengChao Wu, ShuQun Cheng
BACKGROUND: The benefits of transarterial chemoembolization plus sorafenib (TACE-S) in hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT) remain controversial. We compared the effectiveness and safety of TACE-S and TACE for HCC with PVTT. METHODS: The Cochrane Library, PubMed, EMBASE, Chinese National Knowledge Infrastructure, VIP, Wan Fang, and Sino Med databases were systematically searched for studies of HCC with PVTT treated using TACE-S. Two authors independently extracted study outcomes, including overall survival (OS), time to progression (TTP), objective response (tumor response) and adverse events (AEs)...
February 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28148887/mir-146a-and-mir-196a-2-polymorphisms-are-associated-with-hepatitis-virus-related-hepatocellular-cancer-risk-a-meta-analysis
#10
Tian Tian, Meng Wang, Wenge Zhu, Zhi-Ming Dai, Shuai Lin, Peng-Tao Yang, Xing-Han Liu, Kang Liu, Yu-Yao Zhu, Yi Zheng, Meng Liu, Zhi-Jun Dai
Previous studies have investigated the role of miR-146a rs2910164 and miR-196a-2 rs11614913 polymorphisms in hepatocellular carcinoma (HCC) susceptibility, but the results are contradictory and few specifically studied hepatitis virus-related HCC. Therefore, we conducted a meta-analysis to evaluate the association between these two polymorphisms and hepatitis virus-related HCC risk. We performed a systematical search in EMBASE, PubMed, Web of Science, CNKI and Wanfang databases as of 25th November, 2016. Finally, we assessed 14 studies involving 3852 cases and 5275 controls...
January 31, 2017: Aging
https://www.readbyqxmd.com/read/28135674/stress-related-and-basic-determinants-of-hair-cortisol-in-humans-a-meta-analysis
#11
REVIEW
Tobias Stalder, Susann Steudte-Schmiedgen, Nina Alexander, Tim Klucken, Annika Vater, Susann Wichmann, Clemens Kirschbaum, Robert Miller
The analysis of hair cortisol concentrations (HCC) is a relatively new strategy to measure long-term cumulative cortisol levels, which is increasingly used in psychoneuroendocrinological research. Here, we conduct a first comprehensive meta-analysis of HCC research based on aggregated data from a total of 124 (sub)samples (66 independent studies; total N=10,289). We seek to answer two central questions: (i) Which covariates and basic features of HCC need to be considered in future research? (ii) What are the main determinants of HCC in terms of chronic stress exposure and mental health? Concerning basic characteristics, our findings identify several covariates to be considered (age, sex, hair washing frequency, hair treatment, oral contraceptive use), confirm a decline of HCC from the first to the second proximal 3cm hair segment, and show positive associations between HCC and short-term salivary cortisol measures...
January 10, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28116284/strengthening-the-case-that-elevated-levels-of-programmed-death-ligand-1-predict-poor-prognosis-in-hepatocellular-carcinoma-patients
#12
Jian-Hong Zhong, Cheng-Piao Luo, Chun-Yan Zhang, Le-Qun Li
Immunotherapy targeting programmed death receptor 1 and programmed death ligand 1 (PD-L1) has shown impressive antitumor efficacy in several solid cancers, including advanced hepatocellular carcinoma (HCC). Since response rates of various cancers to such immunotherapy appear to correlate with PD-L1 expression levels, several studies have examined whether PD-L1 expression correlates with HCC pathology and patient prognosis. In this paper, we analyzed the strength and limitations of a recent meta-analysis of associations of PD-L1 with HCC characteristics and patient prognosis...
2017: Journal of Hepatocellular Carcinoma
https://www.readbyqxmd.com/read/28109724/the-role-of-cone-beam-ct-in-transcatheter-arterial-chemoembolization-for-hepatocellular-carcinoma-a-systematic-review-and-meta-analysis
#13
Leland Pung, Moiz Ahmad, Kerstin Mueller, Jarrett Rosenberg, Christopher Stave, Gloria L Hwang, Rajesh Shah, Nishita Kothary
PURPOSE: To review available evidence for use of cone-beam CT during transcatheter arterial chemoembolization in hepatocellular carcinoma (HCC) for detection of tumor and feeding arteries. MATERIALS AND METHODS: Literature searches were conducted from inception to May 15, 2016, in PubMed (MEDLINE), Scopus, and Cochrane Central Register of Controlled Trials. Searches included "cone beam," "CBCT," "C-arm," "CACT," "cone-beam CT," "volumetric CT," "volume computed tomography," "volume CT," AND "liver," "hepatic*," "hepatoc*...
January 18, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28099898/the-best-strategy-for-hcc-patients-at-each-bclc-stage-a-network-meta-analysis-of-observational-studies
#14
REVIEW
Lei Chang, Yitao Wang, Jibo Zhang, Tao Guo
BACKGROUND AND AIMS: Currently, the Barcelona Clinic Liver Cancer staging system remains huge controversies in the management of hepatocellular carcinoma. To determine the best therapeutic strategy for patients at each stage, we conducted a network meta-analysis and aimed to provide a new treatment concept. MATERIALS AND METHODS: PubMed, Embase and Cochrane Library database were searched for observational studies up to August 31, 2016. We extracted data on overall survival rate from studies that compared various strategies for use with patients at different stages...
January 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28063180/do-occupational-exposures-to-vinyl-chloride-cause-hepatocellular-carcinoma-and-cirrhosis
#15
Marcello Lotti
Controversy exists about the association between occupational exposures to vinyl chloride and hepatocellular carcinoma and cirrhosis. Two large multicentre mortality cohort studies, one American and another European, reported higher mortality for primary cancer of liver and biliary tract. However, the American study was not able to rule out misclassification, because based on death certificates and under the heading primary liver cancers, some angiosarcomas, the typical neoplasia associated with vinyl chloride, may have been included...
January 7, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28061472/harms-and-benefits-of-adoptive-immunotherapy-for-postoperative-hepatocellular-carcinoma-an-updated-review
#16
Bao-Hong Yuan, Ru-Hong Li, Wei-Ping Yuan, Tian Yang, Tie-Jun Tong, Ning-Fu Peng, Le-Qun Li, Jian-Hong Zhong
The harms and benefits of adoptive immunotherapy (AIT) for patients with postoperative hepatocellular carcinoma (HCC) are controversial among studies. This study aims to update the current evidence on efficacy and safety of AIT for patients with HCC who have received curative therapy. Electronic databases were systematically searched to identify randomized controlled trials (RCTs) and cohort studies evaluating adjuvant AIT for patients with HCC after curative therapies. Recurrence and mortality were compared between patients with or without adjuvant AIT...
January 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28061016/a-meta-analysis-of-single-hcv-untreated-arm-of-studies-evaluating-outcomes-after-curative-treatments-of-hcv-related-hepatocellular-carcinoma
#17
Giuseppe Cabibbo, Salvatore Petta, Marco Barbàra, Gabriele Missale, Roberto Virdone, Eugenio Caturelli, Fabio Piscaglia, Filomena Morisco, Antonio Colecchia, Fabio Farinati, Edoardo Giannini, Franco Trevisani, Antonio Craxì, Massimo Colombo, Calogero Cammà
BACKGROUND & AIMS: Determining risk for recurrence or survival after curative resection or ablation in patients with hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC) is important for stratifying patients according to expected outcomes in future studies of adjuvant therapy in the era of direct-acting antivirals (DAAs). The aims of this meta-analysis were to estimate the recurrence and survival probabilities of HCV-related early HCC following complete response after potentially curative treatment and to identify predictors of recurrence and survival...
January 6, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28053537/comparison-of-intra-arterial-chemoembolization-with-and-without-radiotherapy-for-advanced-hepatocellular-carcinoma-with-portal-vein-tumor-thrombosis-a-meta-analysis
#18
Qianqian Zhao, Kunli Zhu, Jinbo Yue, Zhonghua Qi, Shumei Jiang, Xiaoqing Xu, Rui Feng, Renben Wang
PURPOSE: Numerous studies have tried to combine transarterial chemoembolization (TACE) or hepatic arterial infusion chemotherapy (HAIC) with radiotherapy (RT) for the treatment of hepatocellular carcinoma (HCC) patients with portal vein tumor thrombus (PVTT). However, the efficacy of TACE or HAIC combined with RT versus TACE or HAIC alone remains controversial. Thus, we performed a meta-analysis to compare the efficacy and safety of intra-arterial chemoembolization combined with RT versus intra-arterial chemoembolization alone for the treatment of HCC patients with PVTT...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28045619/impact-of-viral-status-on-survival-in-patients-receiving-sorafenib-for-advanced-hepatocellular-cancer-a-meta-analysis-of-randomized-phase-iii-trials
#19
Richard Jackson, Eftychia-Eirini Psarelli, Sarah Berhane, Harun Khan, Philip Johnson
Purpose Following the Sorafenib Hepatocellular Carcinoma Assessment Randomized Protocol (SHARP) trial, sorafenib has become the standard of care for patients with advanced unresectable hepatocellular carcinoma, but the relation between survival advantage and disease etiology remains unclear. To address this, we undertook an individual patient data meta-analysis of three large prospective randomized trials in which sorafenib was the control arm. Methods Of a total of 3,256 patients, 1,643 (50%) who received sorafenib were available...
February 20, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28042951/prognostic-and-clinicopathologic-significance-of-sirt1-expression-in-hepatocellular-carcinoma
#20
Hongyuan Jiang, Xiao Zhang, Yuquan Tao, Liang Shan, Qijun Jiang, Yongchun Yu, Feng Cai, Lifang Ma
The clinical value of SIRT1 in hepatocellular carcinoma (HCC) remains controversial. This meta-analysis was performed to investigate the prognostic and clinicopathological significance of the histone deacetylase SIRT1 in HCC. Pooled hazard ratios (HRs) for survival outcomes and pooled odds ratios (ORs) for clinical parameters associated with SIRT1 were calculated in nine studies using Review Manager. Meta-analysis showed that increased SIRT1 expression is associated with poor overall survival (OS) (HR=1.82, 95% confidence interval (CI): 1...
December 22, 2016: Oncotarget
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