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https://www.readbyqxmd.com/read/28099898/the-best-strategy-for-hcc-patients-at-each-bclc-stage-a-network-meta-analysis-of-observational-studies
#1
REVIEW
Lei Chang, Yitao Wang, Jibo Zhang, Tao Guo
BACKGROUND AND AIMS: Currently, the Barcelona Clinic Liver Cancer staging system remains huge controversies in the management of hepatocellular carcinoma. To determine the best therapeutic strategy for patients at each stage, we conducted a network meta-analysis and aimed to provide a new treatment concept. MATERIALS AND METHODS: PubMed, Embase and Cochrane Library database were searched for observational studies up to August 31, 2016. We extracted data on overall survival rate from studies that compared various strategies for use with patients at different stages...
January 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28063180/do-occupational-exposures-to-vinyl-chloride-cause-hepatocellular-carcinoma-and-cirrhosis
#2
Marcello Lotti
Controversy exists about the association between occupational exposures to vinyl chloride and hepatocellular carcinoma and cirrhosis. Two large multicentre mortality cohort studies, one American and another European, reported higher mortality for primary cancer of liver and biliary tract. However, the American study was not able to rule out misclassification, because based on death certificates and under the heading primary liver cancers, some angiosarcomas, the typical neoplasia associated with vinyl chloride, may have been included...
January 7, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28061472/harms-and-benefits-of-adoptive-immunotherapy-for-postoperative-hepatocellular-carcinoma-an-updated-review
#3
Bao-Hong Yuan, Ru-Hong Li, Wei-Ping Yuan, Tian Yang, Tie-Jun Tong, Ning-Fu Peng, Le-Qun Li, Jian-Hong Zhong
The harms and benefits of adoptive immunotherapy (AIT) for patients with postoperative hepatocellular carcinoma (HCC) are controversial among studies. This study aims to update the current evidence on efficacy and safety of AIT for patients with HCC who have received curative therapy. Electronic databases were systematically searched to identify randomized controlled trials (RCTs) and cohort studies evaluating adjuvant AIT for patients with HCC after curative therapies. Recurrence and mortality were compared between patients with or without adjuvant AIT...
January 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28061016/a-meta-analysis-of-single-hcv-untreated-arm-of-studies-evaluating-outcomes-after-curative-treatments-of-hcv-related-hepatocellular-carcinoma
#4
Giuseppe Cabibbo, Salvatore Petta, Marco Barbàra, Gabriele Missale, Roberto Virdone, Eugenio Caturelli, Fabio Piscaglia, Filomena Morisco, Antonio Colecchia, Fabio Farinati, Edoardo Giannini, Franco Trevisani, Antonio Craxì, Massimo Colombo, Calogero Cammà
BACKGROUND & AIMS: Determining risk for recurrence or survival after curative resection or ablation in patients with hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC) is important for stratifying patients according to expected outcomes in future studies of adjuvant therapy in the era of direct-acting antivirals (DAAs). The aims of this meta-analysis were to estimate the recurrence and survival probabilities of HCV-related early HCC following complete response after potentially curative treatment and to identify predictors of recurrence and survival...
January 6, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28053537/comparison-of-intra-arterial-chemoembolization-with-and-without-radiotherapy-for-advanced-hepatocellular-carcinoma-with-portal-vein-tumor-thrombosis-a-meta-analysis
#5
Qianqian Zhao, Kunli Zhu, Jinbo Yue, Zhonghua Qi, Shumei Jiang, Xiaoqing Xu, Rui Feng, Renben Wang
PURPOSE: Numerous studies have tried to combine transarterial chemoembolization (TACE) or hepatic arterial infusion chemotherapy (HAIC) with radiotherapy (RT) for the treatment of hepatocellular carcinoma (HCC) patients with portal vein tumor thrombus (PVTT). However, the efficacy of TACE or HAIC combined with RT versus TACE or HAIC alone remains controversial. Thus, we performed a meta-analysis to compare the efficacy and safety of intra-arterial chemoembolization combined with RT versus intra-arterial chemoembolization alone for the treatment of HCC patients with PVTT...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28045619/impact-of-viral-status-on-survival-in-patients-receiving-sorafenib-for-advanced-hepatocellular-cancer-a-meta-analysis-of-randomized-phase-iii-trials
#6
Richard Jackson, Eftychia-Eirini Psarelli, Sarah Berhane, Harun Khan, Philip Johnson
Purpose Following the Sorafenib Hepatocellular Carcinoma Assessment Randomized Protocol (SHARP) trial, sorafenib has become the standard of care for patients with advanced unresectable hepatocellular carcinoma, but the relation between survival advantage and disease etiology remains unclear. To address this, we undertook an individual patient data meta-analysis of three large prospective randomized trials in which sorafenib was the control arm. Methods Of a total of 3,256 patients, 1,643 (50%) who received sorafenib were available...
January 3, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28042951/prognostic-and-clinicopathologic-significance-of-sirt1-expression-in-hepatocellular-carcinoma
#7
Hongyuan Jiang, Xiao Zhang, Yuquan Tao, Liang Shan, Qijun Jiang, Yongchun Yu, Feng Cai, Lifang Ma
The clinical value of SIRT1 in hepatocellular carcinoma (HCC) remains controversial. This meta-analysis was performed to investigate the prognostic and clinicopathological significance of the histone deacetylase SIRT1 in HCC. Pooled hazard ratios (HRs) for survival outcomes and pooled odds ratios (ORs) for clinical parameters associated with SIRT1 were calculated in nine studies using Review Manager. Meta-analysis showed that increased SIRT1 expression is associated with poor overall survival (OS) (HR=1.82, 95% confidence interval (CI): 1...
December 22, 2016: Oncotarget
https://www.readbyqxmd.com/read/28006873/can-response-to-locoregional-therapy-help-predict-long-term-survival-after-liver-transplantation-for-hepatocellular-carcinoma-a-systematic-review
#8
REVIEW
Paul D Morris, Jerome M Laurence, David Yeo, Michael Crawford, Simone I Strasser, Geoffrey W McCaughan, Charbel Sandroussi
Background For a selected group of patients with hepatocellular carcinoma, liver transplantation represents the best chance of cure. Organ shortages necessitate an efficient allocation of resources and careful prioritisation on the transplantation waiting list. In this review we aim to collate and evaluate the published evidence for using response to locoregional therapies, measured by mRECIST, as a predictor of long-term survival after liver transplantation. Objective To assess whether response to locoregional therapies before LT for HCC, as measured by the RECIST or mRECIST criteria, can help predict recurrence-free and/or long-term survival outcomes...
December 22, 2016: Liver Transplantation
https://www.readbyqxmd.com/read/28006010/is-adjuvant-cellular-immunotherapy-essential-after-tace-predominant-minimally-invasive-treatment-for-hepatocellular-carcinoma-a-systematic-meta-analysis-of-studies-including-1774-patients
#9
Min Ding, Ying Wang, Jiachang Chi, Tao Wang, Xiaoyin Tang, Dan Cui, Qijun Qian, Bo Zhai
PURPOSE: Cellular immunotherapy has appeared to be a promising modality for the treatment of malignant tumor. The objective of this study was to evaluate the efficacy of cellular immunotherapy combined with minimally invasive therapy. METHODS: We searched PubMed, Web of Science and The Cochrane Library through March 2016 for relevant studies. Short-term efficacy (the disease control rate, the control rate of quality life and the AFP descent rate) and long-term efficacy (overall survival (OS) and progression-free survival (PFS) rate) were compared as the major outcome measures...
2016: PloS One
https://www.readbyqxmd.com/read/28001023/modified-glasgow-prognostic-score-might-be-a-prognostic-factor-for-hepatocellular-carcinoma-a-meta-analysis
#10
Hong Chen, Nan Hu, Peng Chang, Tao Kang, Song Han, Yaoliang Lu, Maoquan Li
INTRODUCTION: Hepatocellular carcinoma (HCC) is the fifth-most common cancer. Recent studies have demonstrated that there was a relationship between modified Glasgow prognostic score (mGPS) and survival of HCC. However, the results were inconsistent. EVIDENCE ACQUISITION: The following databases were searched for relevant articles published up until June 2016: PubMed; EMBASE; Web of Science and the China National Knowledge Infrastructure. The strength of association between mGPS and OS of HCC was estimated by pooled HRs with corresponding 95% CIs...
December 21, 2016: Panminerva Medica
https://www.readbyqxmd.com/read/28000712/genetic-polymorphisms-137-rs187238-and-607-rs1946518-in-the-interleukin-18-promoter-may-not-be-associated-with-development-of-hepatocellular-carcinoma
#11
Shao-Liang Zhu, Yun Zhao, Xue-Ying Hu, Tao Luo, Zu-Shun Chen, Yu Zhang, Shui-Hua Yang, Lu Zhou, Le-Qun Li
This study meta-analyzed the literature on possible association of polymorphisms -137 (rs187238) and -607 (rs1946518) in the interleukin-18 (IL-18) promoter with risk of hepatocellular carcinoma (HCC). The analysis included 8 case-control studies on the -137 polymorphism (1,318 cases, 2,254 controls) and 7 case-control studies on the -607 polymorphism (1,262 cases, 1,696 controls). None of the five genetic models suggested a significant association between the -137 polymorphism and HCC risk: allelic model, OR 0...
December 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27977601/three-polymorphisms-of-tumor-necrosis-factor-alpha-and-hepatitis-b-virus-related-hepatocellular-carcinoma-a-meta-analysis
#12
Qi Xiao, BiQi Fu, Ping Chen, Zhong Zhong Liu, Wei Wang, QiFa Ye
BACKGROUND: To assess the association between tumor necrosis factor-alpha (TNF-α) G308A, G238A and C863T polymorphisms and hepatitis B virus related hepatocellular carcinoma (HBV-HCC) susceptibility. METHODS: We interrogated the databases of Pubmed, Sciencedirect and Viley online library up to March 8, 2016. Odds ratios (ORs) and corresponding 95% confidence intervals (95%CIs) were calculated in a fixed-effects model or a random-effects model when appropriate. RESULTS: In total, 12 case-control studies which containing 1580 HBV-HCC cases, 2033 HBV carrier controls, 395 HBV spontaneously recovered (SR) controls and 1116 healthy controls were included...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27972388/a-systematic-review-and-meta-analysis-to-access-the-efficacy-and-safety-of-sorafenib-in-advanced-hepatocellular-carcinoma-hcc
#13
M Gollala, R Arora, L Raute, R Kumar, M K Rai
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27960085/molecular-liver-cancer-prevention-in-cirrhosis-by-organ-transcriptome-analysis-and-lysophosphatidic-acid-pathway-inhibition
#14
Shigeki Nakagawa, Lan Wei, Won Min Song, Takaaki Higashi, Sarani Ghoshal, Rosa S Kim, C Billie Bian, Suguru Yamada, Xiaochen Sun, Anu Venkatesh, Nicolas Goossens, Gretchen Bain, Gregory Y Lauwers, Anna P Koh, Mohamed El-Abtah, Noor B Ahmad, Hiroki Hoshida, Derek J Erstad, Ganesh Gunasekaran, Youngmin Lee, Ming-Lung Yu, Wan-Long Chuang, Chia-Yen Dai, Masahiro Kobayashi, Hiromitsu Kumada, Toru Beppu, Hideo Baba, Milind Mahajan, Venugopalan D Nair, Michael Lanuti, Augusto Villanueva, Angelo Sangiovanni, Massimo Iavarone, Massimo Colombo, Josep M Llovet, Aravind Subramanian, Andrew M Tager, Scott L Friedman, Thomas F Baumert, Myron E Schwarz, Raymond T Chung, Kenneth K Tanabe, Bin Zhang, Bryan C Fuchs, Yujin Hoshida
Cirrhosis is a milieu that develops hepatocellular carcinoma (HCC), the second most lethal cancer worldwide. HCC prediction and prevention in cirrhosis are key unmet medical needs. Here we have established an HCC risk gene signature applicable to all major HCC etiologies: hepatitis B/C, alcohol, and non-alcoholic steatohepatitis. A transcriptome meta-analysis of >500 human cirrhotics revealed global regulatory gene modules driving HCC risk and the lysophosphatidic acid pathway as a central chemoprevention target...
December 12, 2016: Cancer Cell
https://www.readbyqxmd.com/read/27936465/meta-analysis-of-transcatheter-arterial-chemoembolization-plus-radiofrequency-ablation-versus-transcatheter-arterial-chemoembolization-alone-for-hepatocellular-carcinoma
#15
De-Jun Yang, Kun-Lun Luo, Hong Liu, Bing Cai, Guo-Qing Tao, Xiao-Fang Su, Xiao-Juan Hou, Fei Ye, Xiang-Yong Li, Zhi-Qiang Tian
This meta-analysis was conducted to compare transcatheter arterial chemoembolization (TACE) plus radiofrequency ablation (RFA) with TACE alone for hepatocellular carcinoma. We searched MEDLINE, EMBASE and CENTRAL for all relative randomized controlled trials (RCTs) and retrospective studies until October 31 2016. Tumor response, recurrence-free survival, overall survival and postoperative complications were the major evaluation indices. Review Manager (version 5.3) was used to analyze the data. Dichotomous data was calculated by odds ratio (OR) with 95% confidence intervals (CI)...
December 7, 2016: Oncotarget
https://www.readbyqxmd.com/read/27931841/new-molecular-therapies-in-patients-with-advanced-hepatocellular-cancer-in-second-line-of-treatment-is-a-real-defeat-results-from-a-literature-based-meta-analysis-of-randomized-trials
#16
REVIEW
Giandomenico Roviello, Laura Zanotti, Maria Rosa Cappelletti, Angela Gobbi, Giulia Borsella, Chiara Pacifico, Andrea Giovanni Multari, Daniele Generali
Several new biological agents have been investigated as second line of treatment in advanced Hepatocellular Cancer (HCC). We performed a meta-analysis to assess the effect of targeted therapies in advanced HCC patients beyond the first line of treatment. A literature-based metaanalysis of randomized controlled trials was undertaken. The primary outcome was the overall survival. The secondary endpoints were the progression-free survival (PFS), the response rate (RR) and disease control rate (DCR) and the safety...
December 2016: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/27931579/harm-and-benefits-of-salvage-transplantation-for-hepatocellular-carcinoma-an-updated-meta-analysis
#17
Q Xiong, T-T Geng, L He, H Gao
OBJECTIVE: The aim of this work was to compare salvage liver transplantation (SLT) and primary liver transplantation (PLT) in terms of the harm and benefits. METHODS: The authors searched Pubmed, Embase, and the Cochrane Library from their dates of establishment to December 2015. Based on selection and exclusion criteria, 2 researchers screened the literature independently. The meta-analysis was performed with the use of the Review Manager software. Meta-analysis of the pooled standard mean difference (SMD) and odds ratio (OR) with 95% confidence interval (CI) were calculated based on either a fixed-effects or a random-effects model...
December 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27930578/short-term-and-long-term-efficacy-of-7-targeted-therapies-for-the-treatment-of-advanced-hepatocellular-carcinoma-a-network-meta-analysis-efficacy-of-7-targeted-therapies-for-ahcc
#18
Meng Niu, Duo Hong, Teng-Chuang Ma, Xiao-Wei Chen, Jin-Hang Han, Jun Sun, Ke Xu
BACKGROUND: A variety of targeted drug therapies in clinical trials have been proven to be effective for the treatment of hepatocellular carcinoma (HCC). Our study aims to compare the short-term and long-term efficacies of different targeted drugs in advanced hepatocellular carcinoma (AHCC) treatment using a network meta-analysis approach. METHODS: PubMed, Embase, Ovid, EBSCO, and Cochrane central register of controlled trials were searched for randomized controlled trials (RCTs) of different targeted therapies implemented to patients with AHCC...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27921403/prognostic-significance-of-regulatory-t-lymphocytes-in-patients-with-hepatocellular-carcinoma
#19
Ai-Bin Zhang, Yi-Gang Qian, Shu-Sen Zheng
We investigated the prognostic role of regulatory T cells (Tregs) in patients with hepatocellular carcinoma (HCC). Relevant evidence regarding prognostic significance of Tregs was systematically searched in MEDLINE and Embase databases. A meta-analysis was performed to compare survival in patients with high or low Tregs level (either in peripheral blood or tumor). Eighteen studies were identified that fulfilled for the eligibility criteria and were included for data synthesis. Our pooled hazard ratios (HRs) demonstrated that increased Tregs intratumoral accumulation was significantly associated with worse overall survival (HR=2...
2016: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/27911861/pyruvate-kinase-m2-pkm2-expression-correlates-with-prognosis-in-solid-cancers-a-meta-analysis
#20
Haiyan Zhu, Hui Luo, Xuejie Zhu, Xiaoli Hu, Lihong Zheng, Xueqiong Zhu
Pyruvate kinase M2 (PKM2) is the key enzyme in the Warburg effect and plays a central role in cancer cell metabolic reprogramming. Recently, quite a few studies have investigated the correlation between PKM2 expression and prognosis in multiple cancer patients, but results were inconsistent. We therefore performed a meta-analysis to explore the prognostic value of PKM2 expression in patients with solid cancer. Here twenty-seven individual studies from 25 publications with a total of 4796 cases were included to explore the association between PKM2 and overall survival (OS) or disease-free survival (DFS)/ progression-free survival (PFS)/ recurrent-free survival (RFS) in subjects with solid cancer...
November 29, 2016: Oncotarget
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