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https://www.readbyqxmd.com/read/28790445/the-prognostic-value-of-tumor-infiltrating-lymphocytes-in-hepatocellular-carcinoma-a-systematic-review-and-meta-analysis
#1
Wei Yao, Jun-Chuang He, Yan Yang, Jian-Ming Wang, Ya-Wei Qian, Tao Yang, Lei Ji
Previous clinical studies have found that the levels of tumor-infiltrating lymphocytes (TILs) significantly correlated with prognosis in hepatocellular carcinoma (HCC). However, these conclusions and data remain controversial. We performed a systematic review and meta-analysis to assess the prognostic value and clinical utilization of TILs in patients with HCC. A total of 23 relevant studies of 3173 patients were included into our meta-analysis. The results demonstrated that high levels of CD8 (+) and CD3 (+) TILs had a better prognostic value on overall survival (OS), with HRs of 0...
August 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28762953/lncrnas-as-prognostic-molecular-biomarkers-in-hepatocellular-carcinoma-a-systematic-review-and-meta-analysis
#2
Chuqian Zheng, Xiuxia Liu, Leifeng Chen, Zheng Xu, Jianghua Shao
The latest studies have shown that long non-coding RNAs (lncRNAs) may be considered markers as their expression levels were abnormal in cancer and can be used as a molecular biomarker for the potential assessment of cancer prognosis. In this study, we aimed to assess the prognostic value of lncRNA as marker of patients with hepatocellular carcinoma. We performed a detailed search of the PubMed and Embase databases for articles on the prognostic value of various lncRNAs in HCC. We then carefully extracted the relevant data from the articles, and we used the meta-analysis method to analyze these results; heterogeneity and publication bias were also evaluated...
July 25, 2017: Oncotarget
https://www.readbyqxmd.com/read/28761441/association-between-hla-dq-gene-polymorphisms-and-hbv-related-hepatocellular-carcinoma
#3
REVIEW
Jingzhu Lv, Tao Xu, Zhongqing Qian, Hongtao Wang
Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related mortality worldwide. Host gene variants may influence hepatitis B virus- (HBV-) related HCC. Human leukocyte antigens (HLA) play an important role in presenting virus antigens to immune cells that are responsible for the clearance of virus-infected cells and tumor cells. Previous studies have investigated the HLA-DQ (rs2856718 and rs9275572) polymorphisms that may be associated with the development of HBV-related HCC. However, the results are controversial or inconclusive...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28746912/transcatheter-hepatic-arterial-chemoembolization-and-sorafenib-for-hepatocellular-carcinoma-a-meta-analysis-of-randomized-double-blind-controlled-trials
#4
Jun Li, Wenhui Liu, Wenhua Zhu, Yinqiao Wu, Benyan Wu
We performed a meta-analysis of transcatheter hepatic arterial chemoembolization (TACE) combined with sorafenib for hepatocellular carcinoma (HCC), which included 4 double-blind, randomized controlled trials (RCTs) that investigated the effects of TACE combined with sorafenib (experimental groups) on time to disease progression (TTP), overall survival (OS), and various sorafenib-related adverse events, compared to those in the placebo (control) groups. A total of 877 HCC cases from 14 countries, including China and the USA, were included in our meta-analysis...
July 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28746202/assessing-diagnostic-value-of-contrast-enhanced-ultrasound-and-contrast-enhanced-computed-tomography-in-detecting-small-hepatocellular-carcinoma-a-meta-analysis
#5
COMPARATIVE STUDY
Jiasheng Huang, Wei Chen, Shanwen Yao
BACKGROUND: This study aimed to compare the diagnostic values of contrast-enhanced ultrasound (CEUS) and contrast-enhanced computed tomography (CECT) in detecting small hepatocellular carcinoma (SHCC). METHODS: A series of related articles from 2001 to 2015 were searched in PubMed and Embase databases. Data from selected articles were pooled to analyze the sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and summary receiver operating characteristic (SROC) curve using Meta-DiSc software...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28746200/promising-significance-of-the-association-of-mir-204-5p-expression-with-clinicopathological-features-of-hepatocellular-carcinoma
#6
Yi-Huan Luo, Wei Tang, Xin Zhang, Zhong Tan, Wen-Liang Guo, Na Zhao, Si-Min Pang, Yi-Wu Dang, Min-Hua Rong, Ji Cao
Decreased level of miR-204-5p has been documented in various malignancies. However, the expression and clinical significance of miR-204-5p in hepatocellular carcinoma has not been investigated. The aim of this study is to examine the relationship between miR-204-5p expression and clinicopathological features in hepatocellular carcinoma (HCC) as well as to predict the relevant signaling pathways. The miR-204-5p expression level was detected in HCC and in matched paraneoplastic liver from 95 formalin-fixed paraffin-embedded tissues by the real-time reverse transcription polymerized chain reaction (qRT-PCR)...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28744145/a-comprehensive-insight-into-the-clinicopathologic-significance-of-mir-144-3p-in-hepatocellular-carcinoma
#7
Hai-Wei Liang, Zhi-Hua Ye, Shu-Ya Yin, Wei-Jia Mo, Han-Lin Wang, Jin-Che Zhao, Guo-Mei Liang, Zhen-Bo Feng, Gang Chen, Dian-Zhong Luo
BACKGROUND: Studies which focused on the character of miR-144-3p in hepatocellular carcinoma (HCC) are limited. This study aimed to explore the expression, clinical significance and the potential targets of miR-144-3p in HCC. METHODS: The Cancer Genome Atlas (TCGA) and a cohort of 95 cases of HCC were applied to investigate aberrant miR-144-3p expression in HCC. A meta-analysis was performed to accumulate data on miR-144-3p expression in HCC based on TCGA, quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and Gene Expression Omnibus (GEO)...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28743838/xpg-gene-rs751402-c-t-polymorphism-and-cancer-risk-evidence-from-22-publications
#8
Haixia Zhou, Ting-Yan Shi, Wenwen Zhang, Qiwen Li, Jinhong Zhu, Jing He, Jichen Ruan
The Xeroderma pigmentosum group G (XPG) gene promotes recognition and excision of damaged DNA during the DNA repair process. We conducted a comprehensive search of the MEDLINE, EMBASE, and Chinese Biomedical databases for publications evaluating the association XPG gene rs751402 C>T polymorphism and overall cancer risk. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were adopted to assess the strength of the association. A total of 22 publications encompassing 10538 cases and 10511 control subjects were included in the final meta-analysis...
July 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28742376/hypervascular-transformation-of-hypovascular-hypointense-nodules-in-the-hepatobiliary-phase-of-gadoxetic-acid-enhanced-mri-a-systematic-review-and-meta-analysis
#9
Chong Hyun Suh, Kyung Won Kim, Junhee Pyo, Jayoun Lee, So Yeon Kim, Seong Ho Park
OBJECTIVE: The purpose of this study is to evaluate the outcomes of hypovascular hypointense nodules in the hepatobiliary phase of gadoxetic acid-enhanced MRI and the risk factors for the hypervascular transformation of the nodules through a systematic review and meta-analysis. MATERIALS AND METHODS: We searched the Ovid-MEDLINE and EMBASE databases for published studies of hypovascular hypointense nodules in patients with chronic liver disease. The pooled proportions of the overall and cumulative incidence rates at 1, 2, and 3 years for the transformation of hypovascular hypointense nodules into hypervascular hepatocellular carcinomas (HCCs) were assessed by using random-effects modeling...
July 25, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28739076/a-meta-analysis-comparing-the-effect-of-anatomical-resection-vs-non-anatomical-resection-on-the-long-term-outcomes-for-patients-undergoing-hepatic-resection-for-hepatocellular-carcinoma
#10
Xinli Huang, Sen Lu
BACKGROUND: This study aimed to compare the outcomes of patients undergoing anatomical resection (AR) versus non-anatomical resection (NAR) for hepatocellular carcinoma (HCC) from the published comparative studies within the literatures. METHODS: A meta-analysis of studies published from 2001 to 2010 were conducted using RevMan 5.0. Measured outcomes were morbidity, mortality, recurrence and 5 year overall (OS) and disease free (DFS) survival. RESULTS: Seventeen observational studies involving 3129 patients were analyzed: 1626 (52%) in AR group and 1503 (48%) in NAR group...
July 21, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28734693/a-systematic-review-and-meta-analysis-comparing-the-prognosis-of-multicentric-occurrence-and-vs-intrahepatic-metastasis-in-patients-with-recurrent-hepatocellular-carcinoma-after-hepatectomy
#11
Sheng-Lan Yang, Ying-Ying Luo, Min Chen, Yan-Ping Zhou, Fu-Rong Lu, Dan-Fang Deng, Yan-Ran Wu
BACKGROUND: The aim of this meta-analysis was to evaluate the prognosis of patients with different types of hepatocellular cancer (HCC) recurrence following hepatectomy. Specifically, it evaluated overall survival and disease-free survival in HCC patients with multicentric occurrence (MO) or intrahepatic metastasis (IM). METHODS: Medline, Cochrane, EMBASE, and Google Scholar were searched until August 22, 2016 using the following search terms: hepatocellular carcinoma, multicentric occurrence, intrahepatic metastasis, early recurrence, and late recurrence...
July 19, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28732353/serum-insulin-like-growth-factor-1-and-its-binding-protein-3-as-prognostic-factors-for-the-incidence-progression-and-outcome-of-hepatocellular-carcinoma-a-systematic-review-and-meta-analysis
#12
Jing Wang, Yu-Chuan Li, Min Deng, Hai-Yin Jiang, Li-Hua Guo, Wen-Juan Zhou, Bing Ruan
PURPOSE: Previous studies have supported an association between serum insulin-like growth factor 1 (IGF1) and IGF-binding protein 3 (IGFBP3) levels and hepatocellular carcinoma (HCC), but the results were inaccurate. It has recently been proposed that IGF1 and IGFBP3 play roles in the time-to-progression (TTP) and overall survival (OS) of HCC patients. Our results revealed that serum IGF1 level is predictive of the progression and survival of HCC patients. RESULTS: HCC was associated with a significant reduction in serum IGF-1 and IGFBP-3 levels compared to cirrhosis (p = 0...
July 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28723763/the-diagnostic-value-of-assays-for-circulating-tumor-cells-in-hepatocellular-carcinoma-a-meta-analysis
#13
Chi Sun, Wenjun Liao, Zefu Deng, Enliang Li, Qian Feng, Jun Lei, Rongfa Yuan, Shubing Zou, Yilei Mao, Jianghua Shao, Linquan Wu, Chao Zhang
PURPOSE: Circulating tumor cells (CTCs) are considered potential biomarkers for the detection of hepatocellular carcinoma (HCC). Many studies have attempted to explore this role, but the results are variable. We conducted the first comprehensive meta-analysis to evaluate the diagnostic value of CTC assay for HCC patients. Additional prognostic value was also assessed. EXPERIMENTAL DESIGN: All articles included in our study were assessed using QUADAS guidelines after a literature search...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28722663/systematic-review-and-meta-analysis-of-the-utility-of-long-non-coding-rna-gas5-as-a-diagnostic-and-prognostic-cancer-biomarker
#14
Wei Li, Na Li, Ke Shi, Qiong Chen
The growth arrest-specific 5 transcript (GAS5) is a long non-coding RNA (lncRNA) involved in the control of cell cycle progression and apoptosis in a wide variety of cells. To determine the clinical value of GAS5 expression in cancer patients, we performed a systematic review and meta-analysis exploring its association with the diagnosis, prognosis, and clinicopathological characteristics of cancer. Ten articles on prognosis, 15 on clinicopathology, and 5 on diagnosis were analyzed. Overall results showed that decreased GAS5 expression associated with unfavorable overall survival (OS) (HR = 2...
July 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28721069/the-effect-of-circulating-mir-223-on-surveillance-of-different-cancers-a-meta-analysis
#15
Yunfeng Zhang, Jinbo Lin, Wenjie Huang, Yong Cao, Yi Liu, Tieqiang Wang, Weiyi Zhong, Dongli Wang, Rongrong Mao, Xiaoliang Chen
PURPOSE: Abnormal expression of miR-223 in cancerous tissue has confirmed it as an important player in tumorigenesis of cancers, such as hepatocellular carcinoma, colorectal carcinoma, osteosarcoma, gastric cancer, and chronic lymphocytic leukemia. The present meta-analysis aimed to explore the association between circulating miR-223 and prognosis of cancers. METHODS: The studies were accessed by an electronic search of multiple databases. RevMan5.3 and STATA14...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28700498/diagnostic-value-of-long-noncoding-rnas-for-hepatocellular-carcinoma-a-prisma-compliant-meta-analysis
#16
REVIEW
Qing-Qin Hao, Guang-Yi Chen, Jun-Hua Zhang, Jia-He Sheng, Yun Gao
BACKGROUND: Increasing evidences have shown that long noncoding RNAs (lncRNAs) are involved in cancer diagnosis and prognosis. However, the overall diagnostic accuracy of lncRNAs for hepatocellular carcinoma (HCC) remains unclear. Herein, we perform a meta-analysis to assess diagnostic value of lncRNAs for HCC. METHODS: The online PubMed, Cochrane, Web of Science, and Embase database were searched for eligible studies published until October 5, 2016. Study quality was evaluated with the Quality Assessment for Studies of Diagnostic Accuracy (QUADAS)...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28699915/circulating-mirnas-as-novel-diagnostic-biomarkers-in-hepatocellular-carcinoma-detection-a-meta-analysis-based-on-24-articles
#17
Yan Ding, Jia-Iai Yan, An-Ning Fang, Wei-Feng Zhou, Ling Huang
The diagnostic value and suitability of circulating miRNAs for the detection of hepatocellular carcinoma have been inconsistent in the literature. A meta-analysis to systematically evaluate the diagnostic value of circulating miRNAs. Eligible studies were selected and the heterogeneity was assessed by subgroup analysis, meta-regression, and publication bias. After strictly and comprehensive screening, the source methods, internal reference and the cut-off values of the included miRNAs were first listed. Circulating miRNAs demonstrated a relatively good diagnostic value in hepatocellular carcinoma, In the subgroup analysis, diagnosis odds ratio showed a higher accuracy with multiple miRNAs than with a single miRNA as well as with serum types than plasma types...
July 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28696069/hcc-associated-single-nucleotide-variants-and-deletions-identified-using-genome-wide-high-throughput-analysis-of-hbv
#18
Wen-Chun Liu, I-Chin Wu, Yen-Chien Lee, Chih-Peng Lin, Ji-Hong Cheng, Yih-Jyh Lin, Chia-Jui Yen, Pin-Nan Cheng, Pei-Fu Li, Yi-Ting Cheng, Pei-Wen Cheng, Koun-Tem Sun, Shu-Ling Yan, Jia-Jhen Lin, Jui-Chu Yang, Kung-Chao Chang, Cheng-Hsun Ho, Vincent S Tseng, Bill Chia-Han Chang, Jaw-Ching Wu, Ting-Tsung Chang
This study investigated hepatitis B virus (HBV) single nucleotide variants (SNVs) and deletion mutations linked with hepatocellular carcinoma (HCC). Ninety-three HCC patients and 108 non-HCC patients were enrolled for HBV genome-wide next-generation sequencing (NGS) analysis. Systemic literature review and meta-analysis were performed to validate NGS-defined HCC-associated SNVs and deletions. The experimental results identified 60 NGS-defined HCC-associated SNVs, including 41 novel SNVs, and their pathogenic frequencies...
July 11, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28693505/effects-of-radiofrequency-ablation-versus-other-ablating-techniques-on-hepatocellular-carcinomas-a-systematic-review-and-meta-analysis
#19
Wen Luo, Yunfei Zhang, Guangbin He, Ming Yu, Minjuan Zheng, Liwen Liu, Xiaodong Zhou
BACKGROUND: Percutaneous ablation has quickly arisen as one of the important alternative treatments for hepatocellular carcinoma (HCC). We aimed to compare the therapeutic effects of radiofrequency ablation (RFA) and other ablative techniques on HCCs. METHODS: Databases were searched to identify literature on complete tumor ablation (CTA), overall survival (OS), local tumor recurrence (LTR), and complications of RFA in the treatment of HCC, compared with those of microwave ablation (MWA), percutaneous ethanol injection (PEI), PEI plus RFA, cryoablation (CRA), laser ablation (LSA), and high-intensity focused ultrasound...
July 10, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28680448/add-on-therapy-with-traditional-chinese-medicine-improves-outcomes-and-reduces-adverse-events-in-hepatocellular-carcinoma-a-meta-analysis-of-randomized-controlled-trials
#20
REVIEW
Zongguo Yang, Xian Liao, Yunfei Lu, Qingnian Xu, Bozong Tang, Xiaorong Chen, Yongchun Yu
BACKGROUND AND AIMS: Traditional Chinese medicine (TCM) therapy for hepatocellular carcinoma remains controversial. This study aimed to evaluate the efficacy and safety of TCM regimens in HCC treatment. METHODS: Randomized controlled trials (RCTs) up to June 1, 2016, of the TCM treatment for hepatocellular carcinoma were systematically identified in PubMed, CNKI, Ovid, Embase, Web of Science, Wanfang, VIP, CBM, AMED, and Cochrane Library databases. RESULTS: A total of 1010 and 931 patients in 20 RCTs were randomly treated with add-on TCM therapy and conventional therapy, respectively...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
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