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https://www.readbyqxmd.com/read/28922704/direct-acting-antivirals-for-chronic-hepatitis-c
#1
REVIEW
Janus C Jakobsen, Emil Eik Nielsen, Joshua Feinberg, Kiran Kumar Katakam, Kristina Fobian, Goran Hauser, Goran Poropat, Snezana Djurisic, Karl Heinz Weiss, Milica Bjelakovic, Goran Bjelakovic, Sarah Louise Klingenberg, Jian Ping Liu, Dimitrinka Nikolova, Ronald L Koretz, Christian Gluud
BACKGROUND: Millions of people worldwide suffer from hepatitis C, which can lead to severe liver disease, liver cancer, and death. Direct-acting antivirals (DAAs), e.g. sofosbuvir, are relatively new and expensive interventions for chronic hepatitis C, and preliminary results suggest that DAAs may eradicate hepatitis C virus (HCV) from the blood (sustained virological response). Sustained virological response (SVR) is used by investigators and regulatory agencies as a surrogate outcome for morbidity and mortality, based solely on observational evidence...
September 18, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28911765/prevalence-of-hepatitis-d-virus-infection-in-sub-saharan-africa-a-systematic-review-and-meta-analysis
#2
Alexander J Stockdale, Mas Chaponda, Apostolos Beloukas, Richard Odame Phillips, Philippa C Matthews, Athanasios Papadimitropoulos, Simon King, Laura Bonnett, Anna Maria Geretti
BACKGROUND: Hepatitis D virus (also known as hepatitis delta virus) can establish a persistent infection in people with chronic hepatitis B, leading to accelerated progression of liver disease. In sub-Saharan Africa, where HBsAg prevalence is higher than 8%, hepatitis D virus might represent an important additive cause of chronic liver disease. We aimed to establish the prevalence of hepatitis D virus among HBsAg-positive populations in sub-Saharan Africa. METHODS: We systematically reviewed studies of hepatitis D virus prevalence among HBsAg-positive populations in sub-Saharan Africa...
October 2017: Lancet Global Health
https://www.readbyqxmd.com/read/28911342/efficacy-and-safety-of-transcatheter-arterial-chemoembolization-and-transcatheter-arterial-chemotherapy-infusion-in-hepatocellular-carcinoma-a-systematic-review-and-meta-analysis
#3
Xinyang Liu, Zhichao Wang, Zongwei Chen, Longzi Liu, Lijie Ma, Liangqing Dong, Zhao Zhang, Shu Zhang, Liuxiao Yang, Jieyi Shi, Jia Fan, Xiaoying Wang, Qiang Gao
Hepatocellular carcinoma (HCC) is a worldwide health threat with increasing incidence and high mortality rate. Most HCCpatients are diagnosed at an advanced stage, and are unable to undergo potential curative surgery. Transcatheter arterial chemoembolization (TACE) and transcatheter arterial chemotherapy infusion (TACI) are two main palliative treatments for advanced HCC patients. The clinical efficacy and safety of TACE and TACI are controversial. For this reason, we conducted the current systematic review and meta-analysis to summarize current evidence...
September 14, 2017: Oncology Research
https://www.readbyqxmd.com/read/28906395/prognostic-impact-of-surgical-margin-in-patients-with-hepatocellular-carcinoma-a-meta-analysis
#4
Fu-Ping Zhong, Yu-Jun Zhang, Ying Liu, Shu-Bing Zou
BACKGROUND: Surgical margin is an important prognostic factor in hepatectomy for patients with hepatocellular carcinoma (HCC). But the extent of surgical margins is still controversial. Our study was designed to systematically evaluate the prognosis of different width of resection margin. METHODS: We conducted comprehensive searches of electronic databases including PubMed, MEDLINE, EMBASE, Cochrane, and the ISI Web of Science for relevant studies. A meta-analysis was performed by RevMan 5...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28901304/efficacy-comparison-of-radiofrequency-ablation-and-hepatic-resection-for-hepatocellular-carcinoma-a-meta-analysis
#5
E Changyong, Dan Wang, Yang Yu, Hongyu Liu, Hui Ren, Tao Jiang
OBJECTIVES: The objective of this study is to compare the therapeutic efficacy of radiofrequency ablation (RFA) and hepatic resection (HR) for the treatment of hepatocellular carcinoma (HCC). MATERIALS AND METHODS: A literature search was performed for comparative studies reporting outcomes of both RFA and HR for HCC. Pooled odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated. RESULTS: A total of 4812 patients with HCC were included, with 2419 in the RFA group and 2393 in the HR group...
2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28891275/cigarette-smoking-as-a-risk-factor-for-the-development-of-and-mortality-from-hepatocellular-carcinoma-an-updated-systematic-review-of-81-epidemiological-studies
#6
Omar Abdel-Rahman, Daniel Helbling, Othmar Schöb, Mostafa Eltobgy, Hadeer Mohamed, Jan Schmidt, Anwar Giryes, Arianeb Mehrabi, Satheesh Iype, Hannah John, Aysun Tekbas, Ahmad Zidan, Hani Oweira
BACKGROUND AND AIMS: Hepatocellular carcinoma (HCC) is the sixth most common cancer worldwide and its incidence has increased during the past decade. While hepatitis B and C virus infections and alcohol were established risk factors, the impact of smoking on the incidence and mortality of HCC was needed to be confirmed. METHODS: We reviewed cohort and case-control studies evaluating the association between cigarette smoking and incidence and mortality of HCC from MEDLINE and Google Scholar...
September 10, 2017: Journal of Evidence-based Medicine
https://www.readbyqxmd.com/read/28886327/association-between-platelet-to-lymphocyte-ratio-plr-and-overall-survival-os-of-hepatocellular-carcinoma-hcc-a-meta-analysis
#7
D-H Hu, S-M Yu
Some studies investigated the association between platelet-to-lymphocyte ratio (PLR) and the survival of hepatocellular carcinoma (HCC). However, the results remained inconclusive. Thus, we performed this meta-analysis. Published studies were searched in PubMed and EMBASE. The strength of association was assessed by calculating odds ratios (OR) and 95% confidence interval (CI). In total, 6 studies with 1446 HCC patients were included in this meta-analysis. HCC with higher PLR showed an increased death risk (OR = 1...
August 30, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28886231/gadoxetic-acid-enhanced-mri-outperformed-mdct-in-diagnosing-small-hepatocellular-carcinoma-a-meta-analysis
#8
Xijiao Liu, Hanyu Jiang, Jie Chen, You Zhou, Zixing Huang, Bin Song
Early detection of small hepatocellular carcinoma (HCC) lesions can improve long-term patient survival. A systematic review and meta-analysis of the diagnostic performance of gadoxetic acid disodium-enhanced magnetic resonance imaging (Gd-EOB-DTPA-enhanced MRI) and multidetector computed tomography (MDCT) was performed in diagnosing small HCCs measuring up to 2 cm(≤2cm). Two investigators searched multiple databases for studies in which the performances of either Gd-EOB-DTPA-enhanced MRI or MDCT were reported with sufficient data to construct 2 × 2 contingency tables for diagnosing HCCs up to 2 cm on a per-lesion or per-patient level...
September 8, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28885338/association-between-mdm2-snp309-p53-arg72pro-and-hepatocellular-carcinoma-risk-a-moose-compliant-meta-analysis
#9
Xiaohua Duan, Jingquan Li
Epidemiological studies have determined the associations between polymorphisms on the promoter of MDM2 (SNP309) and the codon 72 on exon 4 of p53 (p53 Arg72Pro) and the risk of hepatocellular carcinoma (HCC); however, the results were not always consistent. The aim of the present meta-analysis was to evaluate the overall associations between these 2 variants and HCC risk.The MEDLINE, Web of science, EMBASE, Cochrane Library, and CNKI databases were searched for eligibility studies and the data were synthesized under the fixed- or random-effects model...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28881835/xpg-gene-rs751402-c-t-polymorphism-and-cancer-risk-evidence-from-22-publications
#10
Haixia Zhou, Ting-Yan Shi, Wenwen Zhang, Qiwen Li, Jinhong Zhu, Jing He, Jichen Ruan
The Xeroderma pigmentosum group G (XPG) gene promotes recognition and excision of damaged DNA during the DNA repair process. We conducted a comprehensive search of the MEDLINE, EMBASE, and Chinese Biomedical databases for publications evaluating the association XPG gene rs751402 C>T polymorphism and overall cancer risk. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were adopted to assess the strength of the association. A total of 22 publications encompassing 10538 cases and 10511 control subjects were included in the final meta-analysis...
August 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28881735/prognostic-and-clinicopathologic-significance-of-sirt1-expression-in-hepatocellular-carcinoma
#11
Hongyuan Jiang, Xiao Zhang, Yuquan Tao, Liang Shan, Qijun Jiang, Yongchun Yu, Feng Cai, Lifang Ma
The clinical value of SIRT1 in hepatocellular carcinoma (HCC) remains controversial. This meta-analysis was performed to investigate the prognostic and clinicopathological significance of the histone deacetylase SIRT1 in HCC. Pooled hazard ratios (HRs) for survival outcomes and pooled odds ratios (ORs) for clinical parameters associated with SIRT1 were calculated in nine studies using Review Manager. Meta-analysis showed that increased SIRT1 expression is associated with poor overall survival (OS) (HR=1.82, 95% confidence interval (CI): 1...
August 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28881497/therapies-for-advanced-stage-hepatocellular-carcinoma-with-macrovascular-invasion-or-metastatic-disease-a-systematic-review-and-meta-analysis
#12
REVIEW
Richard S Finn, Andrew X Zhu, Farah Wigdan, Jehad Almasri, Feras Zaiem, Larry J Prokop, Mohammad Hassan Murad, Khaled Mohammed
Hepatocellular carcinoma (HCC) is a complex disease most commonly arising in the background of chronic liver disease. In the past two decades there has been a significant increase in our understanding of both the clinical and molecular heterogeneity of HCC. There has been a robust increase in clinical trial activity in patients with poor prognostic factors such as macrovascular invasion and extrahepatic spread. We aimed to synthesize the evidence for the treatment of patients with advanced HCC based on these baseline characteristics including patients with both Child-Pugh scores of A and B...
September 7, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28871164/tumor-infiltrating-cd45ro-memory-t-lymphocytes-predict-favorable-clinical-outcome-in-solid-tumors
#13
Guoming Hu, Shimin Wang
The prognostic role of tumor-infiltrating CD45RO(+) memory T lymphocytes (CD45RO(+) T cells) in human solid tumors remains controversial. Herein, we conducted a meta-analysis including 25 published studies with 4720 patients identified from PubMed and EBSCO to assess the prognostic impact of tumor-infiltrating CD45RO(+) T cells in human solid tumors. We found that CD45RO(+) T cell infiltration was significantly associated with improved overall survival (OS) and disease-free survival (DFS) in all types of solid tumors...
September 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28859233/imaging-for-the-diagnosis-of-hepatocellular-carcinoma-a-systematic-review-and-meta-analysis
#14
REVIEW
Lewis R Roberts, Claude B Sirlin, Feras Zaiem, Jehad Almasri, Larry J Prokop, Julie Heimbach, M Hassan Murad, Khaled Mohammed
Multiphasic computed tomography (CT) and magnetic resonance imaging (MRI) are both used for non-invasive diagnosis of hepatocellular carcinoma (HCC) in patients with cirrhosis. To determine if there is a relative diagnostic benefit of one over the other, we synthesized evidence regarding the relative performances of CT, extracellular-contrast-enhanced-MRI, and gadoxetate-enhanced-MRI for diagnosis of HCC in patients with cirrhosis. We also assessed whether liver biopsy versus follow-up with the same versus alternative imaging is best for CT- or MRI-indeterminate liver nodules in patients with cirrhosis...
August 31, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28859222/therapies-for-patients-with-hepatocellular-carcinoma-awaiting-for-liver-transplantation-a-systematic-review-and-meta-analysis
#15
REVIEW
Laura Kulik, Julie K Heimbach, Feras Zaiem, Jehad Almasri, Larry J Prokop, Zhen Wang, M Hassan Murad, Khaled Mohammed
Patients with hepatocellular carcinoma (HCC) who are listed for liver transplantation are often treated while on the waiting list with loco-regional therapy (LRT) which is aimed at either preventing progression of HCC or reducing themeasurable disease burden of HCC in order to receive increased allocation priority. We aimed to synthesize evidence regarding the effectiveness of LRT in the management of patients with HCC who were on the liver transplant waitlist. We conducted a comprehensive search of multiple databases from 1996 to April 25, 2016, for studies that enrolled adults with cirrhosis awaiting liver transplantation and treated with bridging or down-staging therapies before liver transplantation...
August 31, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28851491/radiofrequency-ablation-versus-resection-for-hepatocellular-carcinoma-in-patients-with-child-pugh-a-liver-cirrhosis-a-meta-analysis
#16
J B Jia, D Zhang, J M Ludwig, H S Kim
AIM: To evaluate whether radiofrequency ablation (RFA) or surgical resection (RES) has superior overall survival (OS) and disease-free survival (DFS) in patients with hepatocellular carcinoma and Child-Pugh class A liver cirrhosis. MATERIALS AND METHODS: Meta-analysis was used to compare 1-, 3-, and 5-year OS and DFS between RFA and RES. Those studies meeting inclusion criteria and published prior to 1 June 2015 were included. The odds ratio (OR) was used as the treatment effect measure...
August 26, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28840293/hepatocellular-carcinoma-imaging-systems-why-they-exist-how-they-have-evolved-and-how-they-differ
#17
An Tang, Irene Cruite, Donald G Mitchell, Claude B Sirlin
Over the past 16 years, several scientific organizations have proposed systems that incorporate imaging for surveillance, diagnosis, staging, treatment, and monitoring of treatment response of hepatocellular carcinoma (HCC). These systems are needed to standardize the acquisition, interpretation, and reporting of liver imaging examinations; help differentiate benign from malignant observations; improve consistency between radiologists; and provide guidance for management of HCC. This review article discusses the historical evolution of HCC imaging systems...
August 24, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28835324/resection-or-transplant-in-early-hepatocellular-carcinoma
#18
Markus B Schoenberg, Julian N Bucher, Adrian Vater, Alexandr V Bazhin, Jingcheng Hao, Markus O Guba, Martin K Angele, Jens Werner, Markus Rentsch
BACKGROUND: Hepatocellular carcinoma (HCC) has an incidence of 5-10 per 100 000 persons per year in the Western world. In 20% of cases, surgical liver resection (LR) or liver transplantation (LT) can be performed. LT results in longer survival, as it involves resection not only of the tumor, but of pre - cancerous tissue as well. The optimal allocation of donor organs depends on the identification of patients for whom LR is adequate treatment. In this meta-analysis, we compare LT and LR for patients with early HCC and wellcompensated cirrhosis...
August 7, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28834146/poor-adherence-to-hepatocellular-carcinoma-surveillance-a-systematic-review-and-meta-analysis-of-a-complex-issue
#19
Changqing Zhao, Mingjuan Jin, Richard Hieu Le, Michael Huan Le, Vincent Lingzhi Chen, Michelle Jin, Grace Lai-Hung Wong, Vincent Wai-Sun Wong, Young-Suk Lim, Wan-Long Chuang, Ming-Lung Yu, Mindie H Nguyen
BACKGROUND & AIMS: Hepatocellular carcinoma (HCC) surveillance is associated with improved outcomes and long-term survival. Our goal is to evaluate adherence rates to HCC surveillance. METHODS: We performed a systematic search of the PubMed and Scopus databases and abstract search of relevant studies from recent major liver meetings. All searches and data extraction were performed independently by 2 authors. Analysis was via random-effects models and multivariate meta-regression...
August 20, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28790445/the-prognostic-value-of-tumor-infiltrating-lymphocytes-in-hepatocellular-carcinoma-a-systematic-review-and-meta-analysis
#20
Wei Yao, Jun-Chuang He, Yan Yang, Jian-Ming Wang, Ya-Wei Qian, Tao Yang, Lei Ji
Previous clinical studies have found that the levels of tumor-infiltrating lymphocytes (TILs) significantly correlated with prognosis in hepatocellular carcinoma (HCC). However, these conclusions and data remain controversial. We performed a systematic review and meta-analysis to assess the prognostic value and clinical utilization of TILs in patients with HCC. A total of 23 relevant studies of 3173 patients were included into our meta-analysis. The results demonstrated that high levels of CD8 (+) and CD3 (+) TILs had a better prognostic value on overall survival (OS), with HRs of 0...
August 8, 2017: Scientific Reports
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