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https://www.readbyqxmd.com/read/28651018/meta-analysis-of-mirna-expression-profiles-for-prostate-cancer-recurrence-following-radical-prostatectomy
#1
Elnaz Pashaei, Elham Pashaei, Maryam Ahmady, Mustafa Ozen, Nizamettin Aydin
BACKGROUND: Prostate cancer (PCa) is a leading reason of death in men and the most diagnosed malignancies in the western countries at the present time. After radical prostatectomy (RP), nearly 30% of men develop clinical recurrence with high serum prostate-specific antigen levels. An important challenge in PCa research is to identify effective predictors of tumor recurrence. The molecular alterations in microRNAs are associated with PCa initiation and progression. Several miRNA microarray studies have been conducted in recurrence PCa, but the results vary among different studies...
2017: PloS One
https://www.readbyqxmd.com/read/28645555/impact-of-intraoperative-vascular-occlusion-during-liver-surgery-on-long-term-outcomes-a-systematic-review-and-meta-analysis
#2
REVIEW
Cheng Gong, Haitao Wang, Pengpeng Liu, Tao Guo
OBJECTIVE: To determine the impact of intraoperative vascular occlusion during liver surgery on postoperative long-term outcomes for hepatocellular carcinoma (HCC) patients using a meta-analysis. METHODS: A systematic literature search of PubMed, EMBASE, and Cochrane Central was conducted to discover relevant randomized controlled trials (RCTs) and observational studies. Studies that reported postoperative long-term outcomes; 1-, 3-, and 5-year overall survival (OS); and/or 1-, 3-, and 5-year recurrence-free survival (RFS) for both an observation group (vascular occlusion) and a control group (vascular non-occlusion) were included...
June 20, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28628947/meta-analysis-of-determinants-of-survival-following-treatment-of-recurrent-hepatocellular-carcinoma
#3
REVIEW
S Erridge, P H Pucher, S R Markar, G Malietzis, T Athanasiou, A Darzi, M H Sodergren, L R Jiao
BACKGROUND: Intrahepatic recurrence of hepatocellular carcinoma (HCC) following resection is common. However, no current consensus guidelines exist to inform management decisions in these patients. Systematic review and meta-analysis of survival following different treatment modalities may allow improved treatment selection. This review aimed to identify the optimum treatment strategies for HCC recurrence. METHODS: A systematic review, up to September 2016, was conducted in accordance with MOOSE guidelines...
June 19, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28621681/overexpression-of-emt-inducing-transcription-factors-as-a-potential-poor-prognostic-factor-for-hepatocellular-carcinoma-in-asian-populations-a-meta-analysis
#4
Tao Wan, Tianwei Zhang, Xiaoying Si, Yanming Zhou
BACKGROUND AND OBJECTIVES: The clinical relevance of epithelial to mesenchymal transition (EMT) in hepatocellular carcinoma (HCC) progression has been highlighted during the last decade. The zinc finger E-box binding homeobox (ZEB) family, the zinc-finger transcriptional repressor (SNAI) family, and the basic helix-loop-helix transcription factor (Twist) family, known as the prominent EMT-inducing transcription factors (EMT-TFs), played a crucial role in the process of EMT. Here, this meta-analysis aimed to evaluate the prognostic value of EMT-TFs high expression in patients with HCC after hepatectomy...
June 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28618942/prognostic-role-of-fibroblast-growth-factor-receptor-2-in-human-solid-tumors-a-systematic-review-and-meta-analysis
#5
REVIEW
Gang Liu, Disheng Xiong, Rui Xiao, Zhengjie Huang
In the past decades, the oncogenic role of fibroblast growth factor receptor 2 has been demonstrated in a number of cancer types. However, studies have reported contradictory findings concerning the correlation between fibroblast growth factor receptor 2 expression and prognosis in solid tumors. To address this discrepancy, we performed a meta-analysis with 18 published studies (2975 patients) retrieved from PubMed, EMBASE, and Web of science. Data were extracted and computed into odds ratios. The results showed that fibroblast growth factor receptor 2 overexpression was significantly associated with decreased 3-year overall survival (odds ratio = 1...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28616586/the-autotaxin-lysophosphatidic-acid-pathway-emerges-as-a-therapeutic-target-to-prevent-liver-cancer
#6
Derek J Erstad, Andrew M Tager, Yujin Hoshida, Bryan C Fuchs
Using transcriptome meta-analysis, we recently identified the autotaxin (ATX)-lysophosphatidic acid (LPA) pathway as a regulator of hepatocellular carcinoma (HCC) risk in human cirrhosis patients. Pharmacological targeting of this pathway reduced fibrosis progression and HCC development in animals, identifying ATX-LPA signaling as a novel chemoprevention strategy for cirrhosis and HCC.
2017: Molecular & Cellular Oncology
https://www.readbyqxmd.com/read/28615529/association-of-three-promoter-polymorphisms-in-interleukin-10-gene-with-cancer-susceptibility-in-the-chinese-population-a-meta-analysis
#7
Ping Wang, Junling An, Yanfeng Zhu, Xuedong Wan, Hongzhen Zhang, Shoumin Xi, Sanqiang Li
Numerous studies have examined the associations of three promoter polymorphisms (-1082A/G, -819T/C and -592A/C) in IL-10 gene with cancer susceptibility in the Chinese population, but the results remain inconclusive. To gain a more precise estimation of this potential association, we conducted the current meta-analysis based on 53 articles, including 26 studies with 4,901 cases and 6,426 controls for the -1082A/G polymorphism, 33 studies with 6,717 cases and 8,550 controls for the -819T/C polymorphism, and 42 studies with 9,934 cases and 13,169 controls for the -592A/C polymorphism...
May 26, 2017: Oncotarget
https://www.readbyqxmd.com/read/28600578/transarterial-infusion-chemotherapy-with-and-without-embolisation-in-hepatocellular-carcinoma-patients-a-systematic-review-and-meta-analysis
#8
Jing Zhao, Dapeng Li, Yue Shi, Fengling Shi, Chengting Feng, Wei Li, Min Tao, Rongrui Liang
INTRODUCTION: The purpose of this meta-analysis was to compare the efficacy of transarterial chemoembolisation (TACE) and iodised oil infusion chemotherapy without embolisation (TAI) in patients with hepatocellular carcinoma. MATERIALS AND METHODS: We searched for randomised controlled trials, retrospective cohort studies, and two-arm prospective studies that compared the clinical outcomes in patients who received TACE and TAI treatment. Database search was performed through 14 December 2016...
May 2017: Annals of the Academy of Medicine, Singapore
https://www.readbyqxmd.com/read/28588882/transarterial-chemoembolization-vs-bland-embolization-in-hepatocellular-carcinoma-a-meta-analysis-of-randomized-trials
#9
Antonio Facciorusso, Francesco Bellanti, Rosanna Villani, Veronica Salvatore, Nicola Muscatiello, Fabio Piscaglia, Gianluigi Vendemiale, Gaetano Serviddio
BACKGROUND: Although transarterial chemoembolization is considered the standard of care for intermediate hepatocellular carcinoma patients, robust data in favor of a clear superiority of chemoembolization (with chemotherapy injection) over bland embolization are lacking. OBJECTIVE: The objective of this article is to systematically analyze the results provided by randomized controlled trials comparing these two treatments in hepatocarcinoma patients. METHODS: A computerized bibliographic search on the main databases was performed...
June 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28585310/direct-acting-antivirals-for-chronic-hepatitis-c
#10
REVIEW
Janus C Jakobsen, Emil Eik Nielsen, Joshua Feinberg, Kiran Kumar Katakam, Kristina Fobian, Goran Hauser, Goran Poropat, Snezana Djurisic, Karl Heinz Weiss, Milica Bjelakovic, Goran Bjelakovic, Sarah Louise Klingenberg, Jian Ping Liu, Dimitrinka Nikolova, Ronald L Koretz, Christian Gluud
BACKGROUND: Millions of people worldwide suffer from hepatitis C, which can lead to severe liver disease, liver cancer, and death. Direct-acting antivirals (DAAs) are relatively new and expensive interventions for chronic hepatitis C, and preliminary results suggest that DAAs may eradicate hepatitis C virus (HCV) from the blood (sustained virological response). However, it is still questionable if eradication of hepatitis C virus in the blood eliminates hepatitis C in the body, and improves survival and leads to fewer complications...
June 6, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28561879/des-gamma-carboxy-prothrombin-in-hepatocellular-cancer-patients-waiting-for-liver-transplant-a-systematic-review-and-meta-analysis
#11
Quirino Lai, Samuele Iesari, Giovanni Battista Levi Sandri, Jan Lerut
BACKGROUND: The use of des-gamma-carboxy prothrombin (DCP) as a predictor of the risk of recurrence of hepatocellular cancer (HCC) after liver transplant (LT) has recently gained interest, especially in view of the recent extension of the eligibility criteria of these patients for LT. The aim of the present study is to look into this important matter based on a systematic review and meta-analysis. METHODS: A systematic literature review about the role of DCP in the specific setting of LT for HCC has been conducted...
May 26, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28559963/identification-of-mir-101-3p-targets-and-functional-features-based-on-bioinformatics-meta-analysis-and-experimental-verification-in-hepatocellular-carcinoma
#12
Chun-Yao Li, Yu-Yan Pang, Hong Yang, Jia Li, Hai-Xia Lu, Han-Lin Wang, Wei-Jia Mo, Lan-Shan Huang, Zhen-Bo Feng, Gang Chen
BACKGROUND: MiR-101-3p has been reported to suppress invasion and metastasis in hepatocellular carcinoma (HCC) cells. However, the relevant mechanisms are still unclear. The research seeks to determine systematic value of miR-101-3p in HCC, and comprehensively summarize the predicted target genes as well as their potential function, pathways and networks in HCC. METHODS: The miR-101-1 profiles in 353 HCC patients from The Cancer Genome Atlas (TCGA) were analyzed...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28552299/transarterial-chemoembolization-in-hepatocellular-carcinoma-with-portal-vein-tumor-thrombosis-a-systematic-review-and-meta-analysis
#13
REVIEW
Jack P Silva, Nicholas G Berger, Susan Tsai, Kathleen K Christians, Callisia N Clarke, Harveshp Mogal, Sarah White, William Rilling, T Clark Gamblin
BACKGROUND: Transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC) with portal vein thrombosis (PVT) remains controversial. This systematic review sought to examine the role of TACE in the treatment of HCC with PVT in either the main portal vein (MPV) or portal vein branches (PVB). METHODS: PubMed was searched for "hepatocellular carcinoma" and "transarterial chemoembolization" from January 1, 2006 to August 31, 2016. Cohorts treated with TACE for HCC with PVT were included...
May 25, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28547124/erratum-to-unresectable-hepatocellular-carcinoma-radioembolization-versus-chemoembolization-a-systematic-review-and-meta-analysis
#14
Laila Lobo, Danny Yakoub, Omar Picado, Caroline Ripat, Fiorella Pendola, Rishika Sharma, Rana ElTawil, Deukwoo Kwon, Shree Venkat, Loraine Portelance, Raphael Yechieli
No abstract text is available yet for this article.
May 25, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28537989/obesity-is-independently-associated-with-increased-risk-of-hepatocellular-cancer-related-mortality-a-systematic-review-and-meta-analysis
#15
Arjun Gupta, Avash Das, Kaustav Majumder, Nivedita Arora, Helen G Mayo, Preet P Singh, Muhammad S Beg, Siddharth Singh
OBJECTIVE: Excess body weight is associated with increased risk of developing hepatocellular cancer (HCC), but its effect on HCC-related mortality remains unclear. We performed a systematic review and meta-analysis to assess the association between premorbid obesity and HCC-related mortality. MATERIALS AND METHODS: Through a systematic literature search-up to March 2016, we identified 9 observational studies (1,599,453 individuals, 5705 HCC-related deaths) reporting the association between premorbid body mass index (BMI), and HCC-related mortality...
May 23, 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28525904/prognostic-value-of-the-microrna-214-in-multiple-human-cancers-a-meta-analysis-of-observational-studies
#16
Yajing Feng, Fujiao Duan, Weigang Liu, Xiaoli Fu, Shuli Cui, Zhenxing Yang
Previous studies showed that microRNA-214 (miR-214) may act as a prognostic biomarker of cancer. However, the available evidence is controversial. This study summarizes evidence and evaluates the prognostic role of miR-214 in various cancers. We carried out a systematic literature review and assessed the quality of included studies based on Oxford Centre for Evidence-based Medicine Criteria and Newcastle-Ottawa Scale (NOS). Pooled hazard ratios (HRs) with corresponding 95% confidence intervals (CIs) for overall survival (OS) and disease free survival/progressive free survival/recurrence free survival (DFS/PFS/RFS) were calculated to measure the effective value of miR-214 expression on prognosis...
May 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28514316/new-idea-for-treatment-strategies-for-barcelona-clinic-liver-cancer-stages-based-on-a-network-meta-analysis
#17
REVIEW
Kun Li, Hai-Tao Wang, Yu-Kun He, Tao Guo
BACKGROUND: Currently, the Barcelona Clinic Liver Cancer staging (BCLC) system still remains controversies in the management of hepatocellular carcinoma. We are trying to determine the best therapeutic strategy for each BCLC stage through a network meta-analysis and provide a new treatment idea. METHODS: We conducted a systematic literature search of the PubMed, EMBASE, and Cochrane Library databases and extracted data from randomized controlled trials (RCTs) that compared various strategies...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28506770/prognostic-role-of-telomere-length-in-malignancies-a-meta-analysis-and-meta-regression
#18
Roman Adam, Laura Díez-González, Alberto Ocaña, Boštjan Šeruga, Eitan Amir, Arnoud J Templeton
Telomere length (TL) has been associated with several health conditions including cancer. To quantify the effect of TL on outcomes in malignancies and explore the role of type of TL measurement we conducted a librarian-led systematic search of electronic databases identified publications exploring the prognostic role of TL on cancer outcomes. Overall survival (OS) was the primary outcome measure while other time-to-event endpoints were secondary outcomes. Data from studies reporting a hazard ratio (HR) with 95% confidence interval (CI) and/or p-value were pooled in a meta-analysis...
May 12, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28499985/functional-mir-146a-mir-149-mir-196a2-and-mir-499-polymorphisms-and-the-susceptibility-to-hepatocellular-carcinoma-an-updated-meta-analysis
#19
Lei Zheng, Chunbo Zhuang, Junwei Zhao, Liang Ming
OBJECTIVE: Single nucleotide polymorphisms of miRNAs play important roles in the pathogenesis of hepatocellular carcinoma (HCC). To evaluate the association between four common miRNAs (miR-146a rs2910164; miR-149 rs2292832; miR-196a2 rs11614913 and miR-499 rs3746444) and HCC risk, an updated meta-analysis was performed. METHODS: 32 studies including 12,405 HCC cases and 15,056 controls were used for this meta-analysis. There were 22 studies with 7894 cases and 10,221 controls for miR-146a, 9 studies with 2684 HCC cases and 3464 controls for miR-149, 17 studies with 6937 cases and 8217 controls for miR-196a2 and 16 studies with 4158 cases and 5264 controls for miR-499...
May 9, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28490552/coffee-including-caffeinated-and-decaffeinated-coffee-and-the-risk-of-hepatocellular-carcinoma-a-systematic-review-and-dose-response-meta-analysis
#20
Oliver John Kennedy, Paul Roderick, Ryan Buchanan, Jonathan Andrew Fallowfield, Peter Clive Hayes, Julie Parkes
OBJECTIVES: To examine the association between coffee, including caffeinated and decaffeinated coffee, with hepatocellular carcinoma (HCC) and assess the influence of HCC aetiology and pre-existing liver disease. DESIGN: We performed a systematic review and meta-analysis. We calculated relative risks (RRs) of HCC according to caffeinated and decaffeinated coffee consumption using a random-effects dose-response meta-analysis. We tested for modification of the effect estimate by HCC aetiology and pre-existing liver disease...
May 9, 2017: BMJ Open
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