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https://www.readbyqxmd.com/read/29792232/effect-of-postoperative-goal-directed-therapy-in-cancer-patients-undergoing-high-risk-surgery-a-randomized-clinical-trial-and-meta-analysis
#1
Aline Rejane Muller Gerent, Juliano Pinheiro Almeida, Evgeny Fominskiy, Giovanni Landoni, Gisele Queiroz de Oliveira, Stephanie Itala Rizk, Julia Tizue Fukushima, Claudia Marques Simoes, Ulysses Ribeiro, Clarice Lee Park, Rosana Ely Nakamura, Rafael Alves Franco, Patricia Inês Cândido, Cintia Rosa Tavares, Ligia Camara, Graziela Dos Santos Rocha Ferreira, Elisangela Pinto Marinho de Almeida, Roberto Kalil Filho, Filomena Regina Barbosa Gomes Galas, Ludhmila Abrahão Hajjar
BACKGROUND: Perioperative goal-directed hemodynamic therapy (GDHT) has been advocated in high-risk patients undergoing noncardiac surgery to reduce postoperative morbidity and mortality. We hypothesized that using cardiac index (CI)-guided GDHT in the postoperative period for patients undergoing high-risk surgery for cancer treatment would reduce 30-day mortality and postoperative complications. METHODS: A randomized, parallel-group, superiority trial was performed in a tertiary oncology hospital...
May 23, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29792083/a-systematic-review-and-meta-analysis-of-the-association-between-vitamin-a-intake-serum-vitamin-a-and-risk-of-liver-cancer
#2
Nattawut Leelakanok, Ronilda R D'Cunha, Grerk Sutamtewagul, Marin L Schweizer
BACKGROUND: Previous evidence supports that vitamin A decreases the risk of several types of cancer. However, the association between vitamin A and liver cancer is inconclusive. AIM: This systematic review and meta-analysis summarizes the existing literature, discussing the association between vitamin A intake, serum vitamin A, and liver cancer in adult populations. METHODS: A systematic literature review was performed by searching the EMBASE, PubMed, Scopus and International Pharmaceutical Abstract databases using terms related to vitamin A (e...
January 1, 2018: Nutrition and Health
https://www.readbyqxmd.com/read/29791500/retraction-calcium-channel-blockers-and-risk-of-breast-cancer-a-meta-analysis-of-17-observational-studies
#3
(no author information available yet)
No abstract text is available yet for this article.
2018: PloS One
https://www.readbyqxmd.com/read/29790998/association-of-smokeless-tobacco-use-and-oral-cancer-a-systematic-global-review-and-meta-analysis
#4
Smita Asthana, Satyanarayana Labani, Uma Kailash, Dhirendra N Sinha, Ravi Mehrotra
Introduction: Smokeless tobacco products have been linked to precancerous and cancers of oral cavity for long. Evidence was available on the association between smokeless tobacco (SLT) products and oral cancers at regional but not at global level. Present meta-analysis is aimed to evaluate the risk of oral cancer with the use of SLT products among "ever" versus "never" users. Method: Studies published for the period (1960-2016) are retrieved using Pubmed, Indmed, EMBASE, and Google Scholar search engines for the subject "ever" versus "never" users of SLT products and estimated the risk association with oral cancer...
May 22, 2018: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/29790976/cancer-dissemination-hydrocephalus-and-survival-after-cerebral-ventricular-entry-during-high-grade-glioma-surgery-a-meta-analysis
#5
Akshitkumar M Mistry, Patrick D Kelly, Reid C Thompson, Lola B Chambless
BACKGROUND: The consequences of ventricular entry during resection of high-grade gliomas (HGG) are uncertain and often not detectable clinically. OBJECTIVE: To reveal odds of tumor dissemination, hydrocephalus, and mortality in adult patients who had ventricular entry during surgical resection of HGG. METHODS: Titles and abstracts of published journals in the NCBI/NLM PubMed and OVID EMBASE databases were searched without language restriction and systematically screened...
May 22, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29790669/genetically-determined-height-was-associated-with-lung-cancer-risk-in-east-asian-population
#6
Lu Wang, Mingtao Huang, Hui Ding, Guangfu Jin, Liang Chen, Feng Chen, Hongbing Shen
The association between adult height and risk of lung cancer has been investigated by epidemiology studies, but the results are inconsistent. Mendelian randomization (MR) analyses with individual-level data from two genome-wide association studies, including a total of 7127 lung cancer cases and 6818 controls, were carried out to explore whether adult height is causally associated with risk of lung cancer. A weighted genetic risk score (wGRS) was created based on genotypes of 101 known height-associated genetic variants...
May 23, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29790566/night-shift-work-and-breast-cancer-risk-what-do-the-meta-analyses-tell-us
#7
Manisha Pahwa, France Labrèche, Paul A Demers
Objectives This paper aims to compare results, assess the quality, and discuss the implications of recently published meta-analyses of night shift work and breast cancer risk. Methods A comprehensive search was conducted for meta-analyses published from 2007-2017 that included at least one pooled effect size (ES) for breast cancer associated with any night shift work exposure metric and were accompanied by a systematic literature review. Pooled ES from each meta-analysis were ascertained with a focus on ever/never exposure associations...
May 22, 2018: Scandinavian Journal of Work, Environment & Health
https://www.readbyqxmd.com/read/29788924/exploration-of-the-association-between-foxe1-gene-polymorphism-and-differentiated-thyroid-cancer-a-meta-analysis
#8
Yong-Hui Chen, Ying-Qiang Zhang
BACKGROUND: Several association analyses and linkage researches indicated that inherited genetic variations effectively influence differentiated thyroid carcinogenesis. METHODS: The results from 15 published studies on differentiated thyroid carcinoma (DTC) were combined. The genetic model included rs965513, rs944289 and rs1867277. Meta-analyses were performed and cochran's χ2 based Q-statistic and I2 test were performed to assess heterogeneity using STATA software...
May 22, 2018: BMC Medical Genetics
https://www.readbyqxmd.com/read/29788736/evaluation-of-overall-survival-rate-of-different-therapies-in-the-treatment-of-t1-t3-prostate-cancer-a-network-meta-analysis
#9
S Y Chen, Y Du, Q Shao, J S Li, H Y Chen
We performed this network meta-analysis (NMA) in order to compare the overall survival rate of six different therapies of T1-T3 prostate cancer (PC). The therapies include radiotherapy (RT), endocrine therapy (ET), Cryoablation (CRYO), radical prostatectomy (RP), RT+ET and RP+ET. Pubmed, Embase, Cochrane Library, Google Scholar, Web of Science and MEDLINE were searched to collect relevant literature from the inception of the study till February 2017. Cohort studies meeting the inclusion criteria were included in the study...
March 14, 2018: Neoplasma
https://www.readbyqxmd.com/read/29788239/circulating-selenium-and-prostate-cancer-risk-a-mendelian-randomization-analysis
#10
James Yarmolinsky, Carolina Bonilla, Philip C Haycock, Ryan J Q Langdon, Luca A Lotta, Claudia Langenberg, Caroline L Relton, Sarah J Lewis, David M Evans, George Davey Smith, Richard M Martin
In the Selenium and Vitamin E Cancer Prevention Trial (SELECT), selenium supplementation (causing a median 114 μg/L increase in circulating selenium) did not lower overall prostate cancer risk, but increased risk of high-grade prostate cancer and type 2 diabetes. Mendelian randomization analysis uses genetic variants to proxy modifiable risk factors and can strengthen causal inference in observational studies. We constructed a genetic instrument comprising 11 single nucleotide polymorphisms robustly (P < 5 × 10-8) associated with circulating selenium in genome-wide association studies...
May 17, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29788170/systematic-review-and-meta-analysis-of-the-evidence-for-oral-nutritional-intervention-on-nutritional-and-clinical-outcomes-during-chemo-radio-therapy-current-evidence-and-guidance-for-design-of-future-trials
#11
M A E de van der Schueren, A Laviano, H Blanchard, M Jourdan, J Arends, V E Baracos
Background: Driven by reduced nutritional intakes and metabolic alterations, malnutrition in cancer patients adversely affects quality of life, treatment tolerance and survival. We examined evidence for oral nutritional interventions during chemo(radio)therapy. Design: We carried out a systematic review of randomized controlled trials (RCT) with either dietary counseling (DC), high-energy oral nutritional supplements (ONS) aiming at improving intakes or ONS enriched with protein and n-3 polyunsaturated fatty acids (PUFA) additionally aiming for modulation of cancer-related metabolic alterations...
May 1, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29788165/physical-activity-in-relation-to-risk-of-prostate-cancer-a-systematic-review-and-meta-analysis
#12
I N Benke, M F Leitzmann, G Behrens, D Schmid
Background: Prostate cancer (PCa) is one of the most common cancers among men, yet little is known about its modifiable risk and protective factors. This study aims to quantitatively summarize observational studies relating physical activity (PA) to PCa incidence and mortality. Materials and methods: Published articles pertaining to PA and PCa incidence and mortality were retrieved in July 2017 using the Medline and EMBASE databases. The literature review yielded 48 cohort studies and 24 case-control studies with a total of 151 748 PCa cases...
May 1, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29788164/what-is-the-optimal-systemic-treatment-of-men-with-metastatic-hormone-naive-prostate-cancer-a-stopcap-systematic-review-and-network-meta-analysis
#13
C L Vale, D J Fisher, I R White, J R Carpenter, S Burdett, N W Clarke, K Fizazi, G Gravis, N D James, M D Mason, M K B Parmar, L H Rydzewska, C J Sweeney, M R Spears, M R Sydes, J F Tierney
Background: Our prior Systemic Treatment Options for Cancer of the Prostate systematic reviews showed improved survival for men with metastatic hormone-naive prostate cancer when abiraterone acetate plus prednisolone/prednisone (AAP) or docetaxel (Doc), but not zoledronic acid (ZA), were added to androgen-deprivation therapy (ADT). Trial evidence also suggests a benefit of combining celecoxib (Cel) with ZA and ADT. To establish the optimal treatments, a network meta-analysis (NMA) was carried out based on aggregate data (AD) from all available studies...
May 1, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29788163/should-de-escalation-of-bone-targeting-agents-be-standard-of-care-for-patients-with-bone-metastases-from-breast-cancer-a-systematic-review-and-meta-analysis
#14
C Liu, L Wang, J Zhuang, L Liu, C Zhou, F Feng, C Sun
No abstract text is available yet for this article.
May 1, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29788041/do-older-and-younger-patients-derive-similar-survival-benefits-from-novel-oncology-drugs-a-systematic-review-and-meta-analysis
#15
Vanessa S Arciero, Sierra Cheng, Robert Mason, Erica McDonald, Ronak Saluja, Kelvin K W Chan
Background: older patients are commonly believed to derive less benefit from cancer drugs, even if they fulfil clinical trial eligibility [Talarico et al. (2004, J Clin Oncol, 22(22):4626-31)]. We aim to examine if novel oncology drugs provide differential age-based treatment outcomes for patients on clinical trials. Methods: a systematic review of randomised control trials (RCTs) cited for clinical efficacy evidence in novel oncology drug approvals by the Food and Drug Administration, European Medicines Agency and Health Canada between 2006 and 2017 was conducted...
May 19, 2018: Age and Ageing
https://www.readbyqxmd.com/read/29787741/the-prognostic-value-of-long-noncoding-rna-sox2ot-expression-in-various-cancers-a-systematic-review-and-meta-analysis
#16
Xiaoyang Song, Hongyan Yao, Jinlin Liu, Qiang Wang
BACKGROUND: Several investigations have explored the prognostic value of long noncoding RNA Sox2 overlapping transcript (lncRNA Sox2ot) expression in human cancers, however, with inconsistent results. The aim of this study was to evaluate the prognostic role of lncRNA Sox2ot expression in various cancers. METHODS: PubMed, Web of Science, Embase, and Cochrane Library were comprehensively searched to retrieve relevant studies. The relationships between lncRNA Sox2ot expression and prognostic parameters were detected, including overall survival (OS), tumor differentiation, clinical stage, distant metastasis, lymph node metastasis and so on...
May 19, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29787421/the-impact-of-saphenous-vein-sparing-during-inguinal-lymphadenectomy-on-postoperative-morbidity-in-women-with-vulval-cancer-an-updated-per-groin-meta-analysis-of-short-term-outcomes
#17
Anastasios Tranoulis, Alexandros Laios, George Theophilou, Konstantinos Bramis, Sean Kehoe
OBJECTIVE: Inguinofemoral lymphadenectomy (IFL) is included in the standard surgical management of early-stage vulval cancer (VC) but is often accompanied by surgical complications. Efforts have been made to limit the postoperative morbidity by adopting more conservative IFL techniques without compromising the surgical outcomes. Saphenous vein (SV) preservation during IFL for VC appears to reduce the incidence of postoperative complications including lymphedema. To ascertain the efficacy of SV preservation, we aimed to revisit the impact of SV preservation on short-term per groin complications by updating on a previous meta-analysis to further guide current clinical practice...
May 22, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29786126/prophylactic-central-compartment-neck-dissection-in-papillary-thyroid-cancer-and-effect-on-locoregional-recurrence
#18
David T Hughes, Jennifer E Rosen, Douglas B Evans, Elizabeth Grubbs, Tracy S Wang, Carmen C Solórzano
BACKGROUND: Prophylactic central compartment neck dissection (pCCND) in addition to total thyroidectomy (TT) includes removal of central compartment lymph nodes in the absence of clinical involvement on preoperative and intraoperative evaluation. The data regarding the influence of pCCND on oncologic outcomes and surgical complication rates is mixed and, therefore, is the focus of this analysis. METHODS: A systematic review of the literature on total thyroidectomy with prophylactic central compartment neck dissection (TT + pCCND) from January 1990 to October 2017 identified 221 abstracts of which 17 met inclusion criteria and were reviewed (1 randomized-control trial, 13 retrospective cohort studies, and 3 meta-analyses)...
May 21, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29786050/diagnostic-performance-of-intestinal-fusobacterium-nucleatum-in-colorectal-cancer-a-meta-analysis
#19
Bo-Jian Peng, Chuang-Yu Cao, Wei Li, Yong-Jian Zhou, Yuan Zhang, Yu-Qiang Nie, Yan-Wen Cao, Yu-Yuan Li
Background: Increasing evidence has supported the link of intestinal Fusobacterium nucleatum infection to colorectal cancer (CRC). However, the value of F. nucleatum as a biomarker in CRC detection has not been fully defined. In order to reduce the random error and bias of individual research, this meta-analysis aimed to evaluate the diagnostic performance of intestinal F. nucleatum in CRC patients and provide evidence-based data to clinical practice. Methods: An article search was performed from PubMed, Embase, Cochrane Library, and Web of Science databases up to December 2017, using the following key words: "Fusobacterium nucleatum", "Fusobacterium spp...
June 5, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29785120/association-between-nr5a2-and-the-risk-of-pancreatic-cancer-especially-among-caucasians-a-meta-analysis-of-case-control-studies
#20
Qun Chen, Hao Yuan, Guo-Dong Shi, Yang Wu, Dong-Fang Liu, Yu-Ting Lin, Lei Chen, Wan-Li Ge, Kuirong Jiang, Yi Miao
Background: Previous studies have reported that nuclear receptor subfamily 5, group A, member 2 (NR5A2) polymorphisms (rs3790843 G>A, rs3790844 T>C, rs12029406 C>T) are associated with the risk of pancreatic cancer. However, the results of epidemiological investigations are still controversial. In order to explore its potential attributing factors, we pooled the updated literatures to evaluate the association between NR5A2 polymorphism and the risk of pancreatic cancer in this meta-analysis...
2018: OncoTargets and Therapy
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