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Limitations of studies with elderly

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https://www.readbyqxmd.com/read/28324002/association-of-nafld-with-diabetes-and-the-impact-of-bmi-changes-a-5-years-cohort-study-based-on-18507-elderly
#1
Miao Liu, Jianhua Wang, Jing Zeng, Xiutang Cao, Yao He
Context: Previous studies about the relation between NAFLD (nonalcoholic fatty liver disease) with diabetes are limited by inconsistent conclusion, mainly being cross-sectional, small sample size, no elderly people, or lack of prediabetes. Objective: This study aimed to examine the relationship between NAFLD with diabetes and prediabetes in a large cohort based on Chinese male elderly. Design: This was a retrospective cohort study that followed up for about 5 years...
January 16, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28319988/travel-distance-to-cancer-treatment-facilities-in-the-deep-south
#2
Mary J Wills, Marilyn V Whitman, Thomas M English
Despite ongoing efforts to improve rural healthcare, the health problems facing rural communities persist. The lack of healthcare providers and infrastructure in rural areas has been linked to a number of negative consequences. Among the elderly rural population, the lack of proximal access presents greater barriers because many elderly people are further limited in their ability to travel and pay for services. In the Deep South specifically, rural residents experience limited access to care and overall poor health outcomes...
January 2017: Journal of Healthcare Management / American College of Healthcare Executives
https://www.readbyqxmd.com/read/28319943/femoral-neck-x-ray-absorptiometry-parameters-and-peripheral-quantitative-computer-tomography-tibial-cortical-density-predict-survival-in-dialysis-patients
#3
Natalie Yap, Phillip Wong, Stella McGinn, Maria-Liza Nery, Jean Doyle, Lynda Wells, Phillip Clifton-Bligh, Roderick J Clifton-Bligh
BACKGROUND: Low bone mineral density (BMD) is a known independent predictor of mortality in the general elderly population. However, studies in patients with end-stage renal disease (ESRD) are limited. The present study evaluated mortality during long-term follow-up in a population of patients having dialysis for ESRD, in whom BMD was also measured. METHODS: Fifty-eight patients with ESRD were recruited consecutively from a dialysis clinic and followed prospectively for 6 years...
March 21, 2017: Nephron
https://www.readbyqxmd.com/read/28319277/the-systematic-review-and-meta-analysis-of-free-flap-safety-in-the-elderly-patients
#4
Galip Gencay Üstün, Ali Emre Aksu, Hakan Uzun, Ozan Bitik
BACKGROUND: Prolonged mean life expectancy gives rise to a more populated and older patient group. With increasing number of cases during the past decades, older patients are regarded as candidates for microsurgical interventions. Whether advanced patient age is an independent risk factor for microsurgical reconstruction is still an ongoing matter of debate. METHODS: The Cochrane Central Register of Controlled Trials, PubMed, MEDLINE, CINAHL and EMBASE databases were screened for combination of the key words "elderly", "geriatric", "advanced age", "free flap", "microsurgery", free tissue transfer" by using time limits between 1989 and 2015...
March 20, 2017: Microsurgery
https://www.readbyqxmd.com/read/28306144/exclusion-of-elderly-people-from-randomized-clinical-trials-of-drugs-for-ischemic-heart-disease
#5
Florence T Bourgeois, Liat Orenstein, Sarita Ballakur, Kenneth D Mandl, John P A Ioannidis
OBJECTIVES: To measure exclusion of elderly adults from randomized trials studying drug interventions for ischemic heart disease (IHD) and describe the characteristics of these trials. DESIGN: Cross-sectional analysis. SETTING: Interventional clinical trials studying a drug intervention for IHD that started in 2006 and after were identified in ClinicalTrials.gov. Data were extracted on study features, including age-based inclusion criteria...
March 17, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28303826/prevalence-of-pneumococcal-serotypes-in-adults-%C3%A2-50-years-of-age
#6
Chand Wattal, Neeraj Goel, S P Byotra
CONTEXT: Currently, majority of studies on antibiotic resistance and serotype prevalence in Streptococcus pneumoniae are in paediatric population and there is limited epidemiologic data pertaining to elderly Indian population. AIMS: This study was undertaken to assess antibiotic resistance pattern and the coverage of the polysaccharide vaccine 23 (PPV23) in the elderly population. SETTINGS AND DESIGN: This was a prospective 2-year pneumococcal surveillance study in patients with community-acquired pneumococcal infections of ≥50 years' age group on fifty isolates of S...
January 2017: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28303062/perception-and-attitude-of-medical-doctors-in-dhaka-bangladesh-with-regard-to-ayurvedic-medicine
#7
Yoshitoku Yoshida, Md Abdul Alim, Zakia Alam, Mohammad Asaduzzaman, Yasuko Yoshida, Shahabuddin Manikdrs
The World Health Organization (WHO) Traditional Medicine Strategy (2014-2023) aimed to help member states promote the safe and effective use of traditional medicine. While economic conditions have markedly improved in Bangladesh, the country is experiencing significant public health problems. Because of limited medical resources, there is a strong incentive to enhance complementary and alternative medicine usage in Bangladesh. Therefore, this study aimed to confirm the perceptions and attitudes of medical doctors (MDs) in Dhaka, Bangladesh, with regard to Ayurvedic medicine (AM)...
February 2017: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28301912/potential-causes-and-implications-of-low-target-therapeutic-ratio-in-warfarin-treated-patients-for-thrombosis-prophylaxis
#8
Halil Atas, Ahmet Anıl Sahin, Dilek Barutçu Atas, Murat Sunbul, Alper Kepez, Mehmet Agirbasli
Time in therapeutic range (TTR) of international normalized ratio is crucial for the safety and efficacy of anticoagulation with warfarin and it is influenced by many factors. There are limited data about the quality of warfarin therapy and its effects on clinical outcomes in Turkey. The aim of this study is to demonstrate the quality of anticoagulant therapy with warfarin and evaluate the parameters that affect the quality of warfarin therapy. A total of 170 patients with atrial fibrillation (AF; mean age: 62...
January 1, 2017: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/28298602/a-single-dose-recombinant-piv5-expressing-respiratory-syncytial-virus-f-and-g-proteins-protected-cotton-rats-and-african-green-monkeys-from-rsv-challenge
#9
Dai Wang, Shannon Phan, Daniel J DiStefano, Michael P Citron, Cheryl L Callahan, Lani Indrawati, Sheri A Dubey, Gwendolyn J Heidecker, Dhanasekaran Govindarajan, Xiaoping Liang, Biao He, Amy S Espeseth
Human respiratory syncytial virus (RSV) is a common cause of severe respiratory disease among infants, immunocompromised individuals and the elderly. No licensed vaccine is currently available. In this study, we evaluated two parainfluenza virus 5 (PIV5)-vectored vaccines expressing RSV F (PIV5/F) or G (PIV5/G) proteins in the cotton rat and African green monkey models for their replication, immunogenicity and efficacy of protection against RSV challenge. Following a single intranasal inoculation, both animal species shed the vaccine viruses for a limited time but without noticeable clinical symptoms...
March 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28297704/successful-aging-from-the-viewpoint-of-older-adults-development-of-a-brief-successful-aging-inventory-sai
#10
Jeong Eun Lee, Boaz Kahana, Eva Kahana
OBJECTIVE: Researcher-defined criteria for successful aging (SA) have been criticized for their limited perspective and failure to acknowledge subjective perceptions of older individuals. We assessed the extent to which older individuals consider specific factors, which they had suggested, to be important in defining SA. The present study had 2 objectives: (a) to develop a brief multidimensional questionnaire for assessing SA and to evaluate its psychometric properties; and (b) to examine age associations with each dimension of SA...
March 16, 2017: Gerontology
https://www.readbyqxmd.com/read/28296815/anterior-trunk-mobility-does-not-predict-disability-in-elderly-women-with-acute-low-back-pain-brazilian-back-complaints-in-the-elders-bace-brazil-study-results
#11
Diogo Carvalho Felicio, Daniele Sirineu Pereira, Juliano Bergamaschine Mata Diz, Barbara Zille de Queiroz, Juscelio Pereira da Silva, Amanda Aparecida Oliveira Leopoldino, Leani Souza Maximo Pereira
STUDY DESIGN: Cross-sectional, ancillary study of an international multicenter epidemiological study. OBJECTIVE: To investigate the relationship of the anterior trunk mobility with self-report and physical performance measures in elderly women with acute low back pain (LBP). SUMMARY OF BACKGROUND DATA: LBP is one of the most prevalent pain complaints in the elderly population. It is postulated that the increased range of motion (ROM) of limited joints of the trunk may improve LBP and functionality of patients...
March 14, 2017: Spine
https://www.readbyqxmd.com/read/28295120/geometric-analysis-of-the-proximal-humerus-in-elderly-japanese-patients-implications-for-implant-selection-in-reverse-shoulder-arthroplasty
#12
Keisuke Matsuki, Hiroyuki Sugaya, Shota Hoshika, Yusuke Ueda, Norimasa Takahashi, Morihito Tokai, Kazutomo Onishi, Scott A Banks
The implants used in reverse shoulder arthroplasty were originally designed for white patients; thus, they might not be optimal for smaller Asian patients. The selection of reverse shoulder arthroplasty systems is limited in Japan. The purpose of this study was to measure the geometry of the proximal humerus in elderly Japanese patients to inform implant selection according to humerus size. This study included 155 shoulders from 148 patients 50 years or older who underwent computed tomography for shoulder disorders other than arthritis and trauma...
March 14, 2017: Orthopedics
https://www.readbyqxmd.com/read/28293105/the-effect-of-visual-biofeedback-on-balance-in-elderly-population-a-systematic-review
#13
REVIEW
Hammad Alhasan, Victoria Hood, Frederick Mainwaring
BACKGROUND: Balance is commonly affected by multiple factors, especially among the elderly population. Visual biofeedback (VBF) is an intervention tool that can be used in balance rehabilitation. AIM: This study aimed to systematically review randomized controlled trials that examine whether VBF training is effective in improving balance in an elderly population. DATA SOURCES: Three databases were searched: CIAHL, EMBASE, and MEDLINE. The searches were limited to the period from 2010 to 2016...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28288956/home-based-intervention-program-to-reduce-food-insecurity-in-elderly-populations-using-a-tv-app-study-protocol-of-the-randomized-controlled-trial-sa%C3%A3%C2%BAde-come-senior
#14
Ana Maria Rodrigues, Maria João Gregório, Pierre Gein, Mónica Eusébio, Maria José Santos, Rute Dinis de Sousa, Pedro S Coelho, Jorge M Mendes, Pedro Graça, Pedro Oliveira, Jaime C Branco, Helena Canhão
BACKGROUND: The limited or uncertain access to adequate food in elderly people includes not only economic restrictions but also inability of food utilization due to functional or cognitive impairment, health problems, and illiteracy. OBJECTIVE: The aim of this work is to present the protocol of the randomized controlled trial Saúde.Come Senior, an educational and motivational television (TV)-based intervention to promote healthy lifestyles and decrease food insecurity in elderly people...
March 13, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28287787/training-working-memory-in-older-adults-is-there-an-advantage-of-using-strategies
#15
Erika Borella, Barbara Carretti, Roberta Sciore, Emanuela Capotosto, Laurence Taconnat, Cesare Cornoldi, Rossana De Beni
The purpose of the present study was to test the efficacy of a working memory (WM) training in elderly people, and to compare the effects of a WM training based on an adaptive procedure with one combining the same procedure with the use of a strategy, based on the construction of visual mental images. Eighteen older adults received training with a WM task (the WM group), another 18 received the same WM training and were also taught to use a visual imagery strategy (the WM + Strategy group), and another 18 served as active controls...
March 2017: Psychology and Aging
https://www.readbyqxmd.com/read/28284210/prognostic-factors-for-gastrectomy-in-elderly-patients-with-gastric-cancer
#16
Daisuke Ueno, Hideo Matsumoto, Hisako Kubota, Masaharu Higashida, Takashi Akiyama, Akiko Shiotani, Toshihiro Hirai
BACKGROUND: The aim of the present study was to investigate the age-specific prognostic factors in patients who underwent gastrectomy for gastric cancer. METHODS: The medical records of 366 patients with gastric cancer who underwent surgical resection at our hospital between January 2007 and December 2014 were retrospectively reviewed. Of the 366 patients, 117 were aged 75 years or older and 249 were aged 74 years or younger. All factors that were identified as significant using univariate analysis were included in the multivariate analysis...
March 11, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28279368/imaging-guided-cardioprotective-treatment-in-a-community-elderly-population-of-stage-b-heart-failure
#17
Hong Yang, Kazuaki Negishi, Ying Wang, Mark Nolan, Thomas H Marwick
OBJECTIVES: The purpose of the study was to evaluate the benefit of care guided by the detection of stage B heart failure (SBHF) using advanced echocardiography for the reduction of new HF in the community. BACKGROUND: The detection of nonischemic SBHF has been facilitated by advanced echocardiographic imaging modalities. However, improved outcomes have not been proven as they are predicated on benefit of treatment. METHODS: Between September 13, 2013 and November 6, 2015, 618 asymptomatic community-based patients with HF risks (age 71 ± 5 years) were randomized to care guided by advanced echocardiography (myocardial deformation and detailed diastolic function) versus usual care...
March 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28276832/the-incidence-and-outcome-of-ischemic-colitis-in-a-population-based-setting
#18
Y Yngvadottir, B R Karlsdottir, J P Hreinsson, G Ragnarsson, R U M Mitev, J G Jonasson, P H Möller, E S Björnsson
OBJECTIVE: Population-based studies on patients with ischemic colitis (IC) are limited. We aimed to determine the incidence, risk factors and outcome of patients with IC. METHODS: A retrospective nationwide study was conducted on adult patients with histologically confirmed IC in 2009-2013 in Iceland. IC patients were matched for age and gender with patients hospitalized with lower gastrointestinal bleeding. Data were collected on clinical presentation, comorbidities, smoking habits, management and outcome...
February 23, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28276253/safety-profiles-of-non-small-cell-lung-cancer-patients-treated-with-pemetrexed-plus-carboplatin-a-real-world-retrospective-observational-cohort-study
#19
Lei Chen, Belen San Antonio, Yu Yan, Jian Chen, Robert J Goodloe, William J John
OBJECTIVE: Pemetrexed plus carboplatin (PCb) is a frequently used first-line treatment in advanced non-small cell lung cancer (NSCLC). This study examined the characteristics and safety profile of a NSCLC population treated with PCb area under the concentration-time curve 5 (PCb5) or 6 mg/mL•min (PCb6) under real-world conditions. RESEARCH DESIGN AND METHODS: A retrospective, observational, cohort study was conducted, utilizing data from the IMS Oncology US clinic-based, longitudinal, patient-level electronic medical records (EMR), including patients with NSCLC on PCb5 or PCb6 regimens initiated concomitantly on or after the diagnosis of lung cancer during 2004-2014...
March 9, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28275301/surgery-for-gastric-cancer-patients-of-age-85-and-older-multicenter-survey
#20
Hirotaka Konishi, Daisuke Ichikawa, Hiroshi Itoh, Kenichiro Fukuda, Naoki Kakihara, Manabu Takemura, Kaori Okugawa, Kiyoshi Uchiyama, Masashi Nakata, Hiroshi Nishi, Toshiyuki Kosuga, Shuhei Komatsu, Kazuma Okamoto, Eigo Otsuji
AIM: To investigate the surgical therapies for gastric cancer (GC) patients of age 85 or older in a multicenter survey. METHODS: Therapeutic opportunities for elderly GC patients have expanded in conjunction with extended life expectancy. However, the number of cases encountered in a single institution is usually very small and surgical therapies for elderly GC patients have not yet been standardized completely. In the present study, a total of 134 GC patients of age 85 or older who underwent surgery in 9 related facilities were retrospectively investigated...
February 21, 2017: World Journal of Gastroenterology: WJG
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