Read by QxMD icon Read


Alan P Rotchford, Anthony J King
AIMS: To determine short-term repeatability of the effect of intraocular pressure (IOP) reducing medication and the number of repeated measurements necessary to estimate therapeutic effect with a given degree of precision. METHODS: IOP was measured at 8:00, 11:00 and 16:00 h at each of three weekly visits in untreated patients with primary open-angle glaucoma or ocular hypertension. After starting travaprost (0.004%) to both eyes, the measurements were repeated for a further three weekly visits...
December 2012: British Journal of Ophthalmology
Maurice Schallenberg, Verena Prokosch, Solon Thanos
Examination of the response of the retinal proteome to elevated intraocular pressure (IOP) and to the pharmacological normalization of IOP is crucial, in order to develop drugs with neuroptorective potential. We used a hereditary rat model of ocular hypertension to lower IOP with travaprost and dorzolamide applied topically on the eye surface, and examine changes of the retinal proteome. Our data demonstrate that elevated IOP causes alterations in the retinal protein profile, in particular in high-mobility-group-protein B1 (HMGB1), calmodulin, heat-shock-protein (HSP) 70 and carbonic anhydrase II expression...
2012: PloS One
Alan P Rotchford, Samreen Uppal, Arun Lakshmanan, Anthony J King
AIMS: To investigate the day-to-day repeatability of intraocular pressure (IOP) measurements. METHODS: A prospective cohort study of untreated patients presenting with primary open-angle glaucoma or ocular hypertension presenting with IOP>21 mm Hg. IOP was measured by masked Goldmann tonometry at 08:00, 11:00 and 16:00 at each of the three weekly visits. After starting travaprost (0.004%) to both eyes, the measurements were repeated for a further three weekly visits...
July 2012: British Journal of Ophthalmology
Anthony J King, Samreen Uppal, Alan P Rotchford, Arun Lakshumanan, Asiya Abedin, Emer Henry
OBJECTIVE: To investigate the validity of the monocular therapeutic trial of therapy in patients commencing topical glaucoma treatment. DESIGN: Prospective intention-to-treat cohort study of untreated patients presenting with open-angle glaucoma or ocular hypertension. PARTICIPANTS: We included 30 treatment-naïve subjects. INTERVENTION: All subjects had 8 visits at which intraocular pressure (IOP) was measured by masked Goldmann tonometry...
November 2011: Ophthalmology
Shunsuke Nakakura, Hitoshi Tabuchi, Yoshiaki Kiuchi
PURPOSE: To report clinical results of switching to latanoprost therapy in patients with deepening of the upper eyelid sulcus caused by travoprost and bimatoprost. METHODS: Prospective, clinical, observational case reports. Four patients presented with eyelid changes giving the eye a sunken eye appearance; two were being treated with travoprost and two with bimatoprost. Both patients on bimatoprost and one of the patients on travoprost therapy were switched to latanoprost while the eyelid sign was evident...
September 2011: Optometry and Vision Science: Official Publication of the American Academy of Optometry
Augusto Paranhos, Marcelo Mendonça, Marcelo Jordão Silva, Jair Giampani, Rogério João Almeida Torres, Mauricio Della Paolera, Heloisa Russ, Claudio Luiz Lottenberg
OBJECTIVE: The aim of this study was to evaluate the change in hyperemia and intraocular pressure (IOP) in patients who switch from prostaglandin or prostamide to a fixed combination of prostamide and timolol maleate. DESIGN: A multicenter, longitudinal, noncontrolled, nonrandomized open trial was conducted. PARTICIPANTS: One hundred forty-four patients (282 eyes) were selected: 60 (41.6%) were on travaprost, 51 (35.4%) on bimatoprost, and 33 (22...
December 2010: Journal of Ocular Pharmacology and Therapeutics
Alberto Diaz, Eva Yebra-Pimentel, Carlos García Resua, Jorge Gilino, Ma Jesus Giraldez
BACKGROUND: The purpose of this study was to assess the accuracy of the ICare tonometer, using the Perkins applanation tonometer (AT) as the reference, in a sample population being treated with travaprost 0.004% for glaucoma. MATERIAL AND METHODS: Twenty-eight consecutive patients with open-angle glaucoma or ocular hypertension who had been receiving travaprost 0.004% to control elevated intraocular pressure (IOP) were included in the study. IOP was measured in the entire sample with ICare and Perkins AT...
January 2008: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
Martin Wand, Alexander R Gaudio
PURPOSE: To report angiographically documented cystoid macula edema associated with the use of each of the three newly available ocular hypotensive lipids: unoprostone, travaprost, and bimatoprost. DESIGN: Observational case series. METHODS: Retrospective review of three patients in a clinical practice who had uncontrolled glaucoma on maximal tolerable therapy except for an ocular hypotensive lipids. All three patients also had previous cataract and filtration surgery, and all had an absent or open posterior lens capsule...
March 2002: American Journal of Ophthalmology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"