Zhi-Qin Cao, Gao-Qian Wang, Rui Luo, Yao-Hui Gao, Jian-Ming Lv, Sheng-Ying Qin, Guo-Dong Chen, Takayoshi Awakawa, Xue-Feng Bao, Qing-Hua Mei, Xin-Sheng Yao, Dan Hu, Ikuro Abe, Hao Gao
Enfumafungin-type antibiotics, represented by enfumafungin and fuscoatroside, belong to a distinct group of triterpenoids derived from fungi. These compounds exhibit significant antifungal properties with ibrexafungerp, a semisynthetic derivative of enfumafungin, recently gaining FDA's approval as the first oral antifungal drug for treating invasive vulvar candidiasis. Enfumafungin-type antibiotics possess a cleaved E-ring with an oxidized carboxyl group and a reduced methyl group at the break site, suggesting unprecedented C-C bond cleavage chemistry involved in their biosynthesis...
April 23, 2024: Journal of the American Chemical Society