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Medications milk lactating

Nguyen Vo, Tsung Cheng Tsai, Charles Maxwell, Franck Carbonero
Reduced microbial exposure in early childhood is postulated to be associated with subsequent immune deficiencies and associated health conditions. This corollary to the "hygiene hypothesis" has grown of popularity in the medical field, but can only be really tested with animal models. Based on previous observation that access to outdoor environment improves piglets' growth performance, we simulated early microbial exposure by providing pigs with topsoil during the lactation phase. Specifically, pigs from 20 litters were assigned to either control treatments (C) or soil treatments (S): pigs exposed to topsoil from day 4 postpartum to the end of lactation...
February 27, 2017: Anaerobe
R Ruiz, L O Tedeschi, A Sepúlveda
This study analyzed the efficacy of pegbovigrastim (Imrestor, Elanco Animal Health, Greenfield, IN) on some health and production parameters in lactating dairy cows. Primiparous and multiparous Holsteins from 17 Mexican dairy herds (n = 10,238) were included in this study, which was conducted in 2015. Treated cows (n = 5,025) received Imrestor approximately 7 d before expected calving and again within 24 h after calving; control cows (n = 5,213) did not receive a placebo. Clinical mastitis (MAS; 0 to 30 DIM), retained placenta (RP), and clinical metritis (MET; 0 to 21 DIM) occurrences were recorded, as well as the number of medication days, medical treatments needed, and the number of days that milk was discarded due to medication administered for disease...
February 1, 2017: Journal of Dairy Science
S M Brown, K A Aljefri, R Waas, P J Hampton
Prescribing for pregnant or lactating patients and male patients wishing to father children can be a difficult area for dermatologists. There is a lack of review articles of commonly used systemic medications in dermatology with respect to their effects on developing embryogenesis and their potential transfer across the placenta, in breast milk and in seminal fluid. This paper aims to provide an up to date summary of evidence to better equip dermatologists to inform patients about the effects of systemic medications commonly used in dermatology to treat conditions such as atopic dermatitis, psoriasis and acne, on current and future embryogenesis and fertility...
January 16, 2017: Journal of Dermatological Treatment
Alessandra N Bazzano, Rebecca Hofer, Shelley Thibeau, Veronica Gillispie, Marni Jacobs, Katherine P Theall
BACKGROUND: Therapeutic approaches to addressing insufficient lactation are available but remain poorly understood. Current trends in maternal health, such as increasing rates of obesity, delayed age at childbearing, and high rates of cesarean section, may be associated with physiological challenges for lactation that cannot be managed by counseling alone. Women who have not had success with counseling alone, including adoptive mothers seeking to induce lactation, may use galactagogues (pharmaceutical and herbal compounds used to increase lactation)...
2016: Ochsner Journal
Taylor M Mehta, Ryan J Van Lieshout
Clozapine is an antipsychotic used in the management of treatment-resistant schizophrenia. However, little is known about clozapine use during pregnancy and lactation, or its impact on the mother, foetus, and infant. This review aims to summarize the available literature on the safety of clozapine use during the perinatal period. EMBASE, PsycINFO, and MEDLINE were searched from their inceptions through June 2016. The review encompasses 21 studies that have examined clozapine use during pregnancy and lactation...
February 2017: Archives of Women's Mental Health
Lisa H Amir, Anita Bearzatto
BACKGROUND: Women who are breastfeeding often consult their general practitioner (GP) with concerns about nipple and breast pain, or the adequacy of their milk supply. Common concerns for their breastfed infant include slow weight gain, 'fussiness' with breastfeeding and 'funny stools'. OBJECTIVE: This article offers suggestions for clinicians to support breastfeeding women and their infants. DISCUSSION: Good attachment to the breast is important to reduce nipple pain and trauma, and to ensure adequate breast drainage and ongoing milk supply...
August 2016: Australian Family Physician
Isabella Pacchiarotti, Jordi León-Caballero, Andrea Murru, Norma Verdolini, Maria Antonietta Furio, Corinna Pancheri, Marc Valentí, Ludovic Samalin, Eva Solé Roigé, Ana González-Pinto, Jose Manuel Montes, Antonio Benabarre, Jose Manuel Crespo, Consuelo de Dios Perrino, Jose Manuel Goikolea, Luis Gutiérrez-Rojas, André F Carvalho, Eduard Vieta
Breast milk is considered the best source of nutrients and provides much better protection than immune modified milk. However, the postpartum period is a phase of increased risk for all women to experience psychiatric symptoms and recurrences or new episodes of bipolar disorder (BD), especially in those who have discontinued treatment. This is a systematic review of the risks and benefits of mood stabilizers and antipsychotics during breastfeeding as they relate to the health and well-being of mothers and their infants...
October 2016: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
Kristin P Tully, Diane Holditch-Davis, Susan Silva, Debra Brandon
BACKGROUND: Late preterm birth is associated with lower rates of breastfeeding and earlier breastfeeding cessation than term birth. PURPOSE: The objectives of this secondary analysis were to compare the incidence of exclusive breastfeeding after late preterm and term childbirth and to examine the association between infant feeding outcomes and maternal emotional well-being. METHODS: Participants were 105 mother-infant dyads (54 late preterm and 51 term) at a southeastern US medical center...
February 2017: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
Catherine Boyce, Mistral Watson, Grace Lazidis, Sarah Reeve, Kenneth Dods, Karen Simmer, Gemma McLeod
There are wide variations in the macronutrient values adopted by neonatal intensive care units and industry to fortify milk in efforts to achieve recommended intakes for preterm infants. Contributing to this is the variation in macronutrient composition of preterm milk between and within mothers and the variable quality of milk analyses used to determine the macronutrient content of milk. We conducted a systematic review of the literature using articles published in English between 1959 and 2013 that reported the concentrations of one or more macronutrients or energy content in human preterm milk, sampled over a representative 24-h period...
September 2016: British Journal of Nutrition
B Popova, D Mitev, A Nikolov
Breast feeding provides a lot of short and long-term benefits for the mother and the baby. It prevents the baby of gastrointestinal, urinary and respiratory infections, atopical conditions and assures long-term protection of cardiovascular and metabolic diseases. The breast feeding decreases the risk for the mother of ovary and breast carcinoma and creates a positive emotional bond between the mother and the baby Mother's milk is a species specific; its content is relatively stable regardless of mother's age race, way and place of living...
2016: Akusherstvo i Ginekologii︠a︡
Fernanda Rodrigues Salazar, Felipe Bianchini D'Avila, Marcella Herbstrith de Oliveira, Pamela Lukasewicz Ferreira, Ana Maria Bergold
The use of medications during lactation is a common practice; however, pharmacological treatments impose serious doubts to both professionals and nursing mothers regarding the safety of drugs used during this period. Most of drugs are excreted in breast milk and there is great variability in the amount of analytes that can be received by the infant. Dilemmas about breastfeeding arise most commonly in relation to postpartum depression. Depression is a major clinical problem during the postpartum period and the vulnerability to onset or recurrence of depressive symptoms increases the possibility of psychotropic drug use during lactation...
September 10, 2016: Journal of Pharmaceutical and Biomedical Analysis
Amber Brook Smathers, Shawn Collins, Ian Hewer
Breastfeeding has been shown to be beneficial in the development of infants, but sometimes, the breastfeeding mother may require anesthesia. It is important for perianesthesia caregivers to understand how the breastfed infant may be affected by the anesthetic medications received by the breastfeeding mother. This article reviews current literature on drug transfer into breast milk and specifically how anesthetic drugs may affect breastfed infants. The pharmacokinetics of drug transfer during lactation is described as well as considerations for perianesthesia providers when caring for breastfeeding patients...
August 2016: Journal of Perianesthesia Nursing: Official Journal of the American Society of PeriAnesthesia Nurses
Lisa M Noguchi, Elizabeth T Montgomery, Joseph R Biggio, Craig W Hendrix, Debra L Bogen, Sharon L Hillier, James Y Dai, Jeanna M Piper, Mark A Marzinke, Charlene S Dezzutti, S Karen Isaacs, Jill L Schwartz, D Heather Watts, Richard H Beigi
Lactation studies are necessary evaluations of medications for reproductive-age women. We evaluated pharmacokinetics (PK), pharmacodynamics, safety, and adherence profiles associated with 7 days of 1% tenofovir (TFV) vaginal gel use during lactation. Tenofovir levels (maternal/infant serum, milk) and anti-HIV activity (milk), adverse events (AEs), and adherence were measured for 17 HIV-1-seronegative breast-feeding mother-infant pairs. Tenofovir use was well-tolerated and detected at low levels in maternal serum, milk, and infant serum but demonstrated no anti-HIV activity in milk...
September 2016: Antimicrobial Agents and Chemotherapy
Shayesteh Jahanfar, Chirk Jenn Ng, Cheong Lieng Teng
BACKGROUND: Mastitis can be caused by ineffective positioning of the baby at the breast or restricted feeding. Infective mastitis is commonly caused by Staphylococcus aureus . The prevalence of mastitis in breastfeeding women may reach 33%. Effective milk removal, pain medication and antibiotic therapy have been the mainstays of treatment. OBJECTIVES: This review aims to examine the effectiveness of antibiotic therapies in relieving symptoms for breastfeeding women with mastitis with or without laboratory investigation...
May 2016: São Paulo Medical Journal, Revista Paulista de Medicina
Jetta Tuokkola, Päivi Luukkainen, Minna Kaila, Hanna-Mari Takkinen, Sari Niinistö, Riitta Veijola, Lauri J Virta, Mikael Knip, Olli Simell, Jorma Ilonen, Suvi M Virtanen
Maternal nutrient intake during pregnancy and lactation potentially influences the development of allergic diseases. Cows' milk allergy (CMA) is often the first manifestation of atopic diseases, but the impact of early nutritional influences on CMA has not been explored. The associations between maternal intakes of folate, folic acid and vitamin D during pregnancy and lactation were addressed in a prospective, population-based birth cohort within the Finnish Type 1 Diabetes Prediction and Prevention Study. Mothers of 4921 children during pregnancy and 2940 children during lactation provided information on maternal dietary intake during the 8th month of pregnancy and the 3rd month of lactation using a detailed, validated FFQ...
August 2016: British Journal of Nutrition
Cynthia L Miltenburg, Todd F Duffield, Dorothee Bienzle, Elizabeth L Scholtz, Stephen J LeBlanc
Prophylactic Ca supplementation immediately after calving is a common strategy to prevent clinical and subclinical hypocalcemia in parturient dairy cows. The objective of this study was to evaluate the effect of prophylactic administration of an injected Ca supplement on blood Ca concentration at 24 and 48h after treatment, incidence risk of clinical disease and culling, milk production in early lactation, and probability of pregnancy at first insemination. Cows without signs of visible milk fever (n=984) from 7 farms were blocked by parity and randomly assigned to receive either Ca gluconate (35% wt/vol) in combination with Ca glucoheptonate (10% wt/vol; TheraCalcium, Vétoquinol Canada Inc...
August 2016: Journal of Dairy Science
Leónides Fernández, Pilar Mediano, Ricardo García, Juan M Rodríguez, María Marín
Objectives Lactational mastitis frequently leads to a premature abandonment of breastfeeding; its development has been associated with several risk factors. This study aims to use a decision tree (DT) approach to establish the main risk factors involved in mastitis and to compare its performance for predicting this condition with a stepwise logistic regression (LR) model. Methods Data from 368 cases (breastfeeding women with mastitis) and 148 controls were collected by a questionnaire about risk factors related to medical history of mother and infant, pregnancy, delivery, postpartum, and breastfeeding practices...
September 2016: Maternal and Child Health Journal
Christine Manipon
BACKGROUND: Our current culture defines breastfeeding and the use of human breast milk as the preferred criterion standard for infant nutrition. Medical and health professionals have a responsibility to support breastfeeding in the mother-infant dyad. This includes the recognition of anatomical barriers to breastfeeding such as a tongue-tie, ankyloglossia. PURPOSE: The purpose of this article is to enrich and expand the clinical knowledge of health professionals about the physical assessment of ankyloglossia and its impact on breastfeeding...
April 2016: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
Peter A Lockwood, Lynne Pauer, Joseph M Scavone, Maud Allard, Laure Mendes da Costa, Tanja Alebic-Kolbah, Anna Plotka, Christine W Alvey, Marci L Chew
BACKGROUND: Limited data exist on the presence of pregabalin in human breast milk of nursing mothers. OBJECTIVES: This study aimed to determine pregabalin concentrations in breast milk, estimate the infant daily pregabalin dose from nursing mothers, and evaluate pregabalin pharmacokinetic data in lactating women (≥ 12 weeks postpartum). METHODS: In this multiple-dose, open-label, pharmacokinetic study, 4 doses of pregabalin 150 mg were administered orally at 12-hour intervals...
March 9, 2016: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
Craig S McConnel, Chloe M Stenkamp-Strahm, Sangeeta Rao, Lyndsey M Linke, Roberta J Magnuson, Doreene R Hyatt
Escherichia coli O157 (EcO157) infections can lead to serious disease and death in humans. Although the ecology of EcO157 is complex, ruminant animals serve as an important reservoir for human infection. Dairy cattle are unique because they may be a source of contamination for milk, meat, and manure-fertilized crops. Foodborne dairy pathogens such as EcO157 are of primary importance to public health. Antimicrobial resistance (AMR) is a complex phenomenon that complicates the treatment of serious bacterial infections and is of increasing concern...
March 2016: Journal of Food Protection
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