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https://www.readbyqxmd.com/read/29346580/smoking-sex-and-non-small-cell-lung-cancer-steroid-hormone-receptors-in-tumor-tissue-s0424
#1
Ting-Yuan David Cheng, Amy K Darke, Mary W Redman, Gary R Zirpoli, Warren Davis, Rochelle Payne Ondracek, Wiam Bshara, Angela R Omilian, Robert Kratzke, Mary E Reid, Julian R Molina, Jill M Kolesar, Yuhchyau Chen, Robert M MacRae, James Moon, Philip Mack, David R Gandara, Karen Kelly, Regina M Santella, Kathy S Albain, Christine B Ambrosone
Background: To what extent steroid hormones contribute to lung cancer in male and female never smokers and smokers is unclear. We examined expression of hormone receptors in lung tumors by sex and smoking. Methods: Patients with primary non-small cell lung cancer were recruited into an Intergroup study in the United States and Canada, led by SWOG (S0424). Tumors from 813 cases (450 women and 363 men) were assayed using immunohistochemistry for estrogen receptor (ER)-α, ER-β, progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2)...
January 13, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29346340/disparities-in-preconception-health-indicators-%C3%A2-behavioral-risk-factor-surveillance-system-2013-2015-and-pregnancy-risk-assessment-monitoring-system-2013-2014
#2
Cheryl Robbins, Sheree L Boulet, Isabel Morgan, Denise V D'Angelo, Lauren B Zapata, Brian Morrow, Andrea Sharma, Charlan D Kroelinger
PROBLEM/CONDITION: Preconception health is a broad term that encompasses the overall health of nonpregnant women during their reproductive years (defined here as aged 18-44 years). Improvement of both birth outcomes and the woman's health occurs when preconception health is optimized. Improving preconception health before and between pregnancies is critical for reducing maternal and infant mortality and pregnancy-related complications. The National Preconception Health and Health Care Initiative's Surveillance and Research work group suggests ten prioritized indicators that states can use to monitor programs or activities for improving the preconception health status of women of reproductive age...
January 19, 2018: MMWR. Surveillance Summaries: Morbidity and Mortality Weekly Report. Surveillance Summaries
https://www.readbyqxmd.com/read/29346046/ultrasonographic-characteristics-of-the-reproductive-tract-and-serum-progesterone-and-estradiol-concentrations-in-captive-female-red-wolves-canis-rufus-with-and-without-reproductive-tract-disease
#3
Kadie M Anderson, Mandi W Schook, Karen L Goodrowe, William T Waddell, Karen N Wolf
OBJECTIVE To describe ultrasonographic characteristics of the reproductive tract and serum progesterone and estradiol concentrations in captive female red wolves (Canis rufus) with and without reproductive tract disease. DESIGN Prospective study. ANIMALS 13 adult female red wolves. PROCEDURES Wolves with varying parity and history of contraceptive treatment were anesthetized to facilitate ultrasonographic examination and measurement of the reproductive tract and blood collection for determination of serum progesterone and estradiol concentrations in December 2011 and June 2012...
February 1, 2018: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29344839/risk-factors-of-venous-thrombo-embolism-during-cytomegalovirus-infection-in-immunocompetent-individuals-a-systematic-review
#4
REVIEW
Manuela Ceccarelli, Emmanuele Venanzi Rullo, Giuseppe Nunnari
Most of the effects and complications of cytomegalovirus (CMV) infection are still unknown, even though its tropism for the endothelium has been extensively investigated. In fact, CMV is suspected to be a cause of venous thrombo-embolism (VTE) since 1974, but there is still no consensus about the management of CMV-related thrombosis and how to prevent it. Cytomegalovirus-related thrombosis has been reported mostly in immunocompromised patients, rarely in immunocompetent individuals. In order to identify potential risk factors of CMV-related thrombosis, we performed a systematic review of the literature regarding immunocompetent patients with cytomegalovirus infection and thrombosis...
January 18, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29343307/informed-choice-and-female-sterilization-in-south-asia-and-latin-america
#5
Apoorva Jadhav, Emily Vala-Haynes
Globally, female sterilization is one of the most popular contraceptive methods despite concerns about quality of care for women who report being sterilized. In this study, informed choice among sterilized women was quantified using Demographic and Health Survey (DHS) data from 2000 to 2012 for countries in South Asia and Latin America. Three responses measured informed choice and knowledge about whether women were informed by a health worker or provider: that sterilization is permanent, the potential side-effects of sterilization and other methods of contraception...
January 18, 2018: Journal of Biosocial Science
https://www.readbyqxmd.com/read/29342175/immunocontraceptive-target-repertoire-defined-by-systematic-identification-of-sperm-membrane-alloantigens-in-a-single-species
#6
Nathaly Cormier, John J McGlone, John Leszyk, Daniel M Hardy
Sperm competence in animal fertilization requires the collective activities of numerous sperm-specific proteins that are typically alloimmunogenic in females. Consequently, sperm membrane alloantigens are potential targets for contraceptives that act by blocking the proteins' functions in gamete interactions. Here we used a targeted proteomics approach to identify the major alloantigens in swine sperm membranes and lipid rafts, and thereby systematically defined the repertoire of these sperm-specific proteins in a single species...
2018: PloS One
https://www.readbyqxmd.com/read/29340488/impact-of-continuous-positive-airway-pressure-on-the-pulmonary-changes-promoted-by-immersion-in-water
#7
Danize Aparecida Rizzetti, Janayna Rodembuch Borba Quadros, Bruna Esmerio Ribeiro, Letícia Callegaro, Aline Arebalo Veppo, Giulia Alessandra Wiggers, Franck Maciel Peçanha
OBJECTIVE: To determine whether different levels of CPAP improve the lung volumes and capacities of healthy subjects immersed in water. METHODS: This was a randomized clinical trial, conducted between April and June of 2016, involving healthy female volunteers who were using oral contraceptives. Three 20-min immersion protocols were applied: control (no CPAP); CPAP5 (CPAP at 5 cmH2O); and CPAP10 (CPAP at 10 cmH2O). We evaluated HR, SpO2, FVC, FEV1, the FEV1/FVC ratio, peak expiratory flow rate (PEFR), and FEF25-75%) at three time points: pre-immersion; 10 min after immersion; and 10 min after the end of each protocol...
November 2017: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/29336615/pharmacokinetic-bioequivalence-safety-and-acceptability-of-ornibel%C3%A2-a-new-polymer-composition-contraceptive-vaginal-ring-etonogestrel-ethinylestradiol-11-00-3-474%C3%A2-mg-compared-with-nuvaring%C3%A2-etonogestrel-ethinylestradiol-11-7-2-7%C3%A2-mg
#8
Jaime Algorta, Maria Diaz, Raquel de Benito, Marc Lefebvre, Eric Sicard, Milton Furtado, Pedro Antonio Regidor, Celestino Ronchi
OBJECTIVE: To show the clinical development of Ornibel® (ExeltisHealthcare, Spain) a contraceptive vaginal ring manufactured with a new polymer composition and containing etonogestrel/ethinylestradiol, compared to Nuvaring® (MSD, Spain). SUBJECTS AND METHODS: Randomised, single dose, 2-period, 2-sequence, 2-stage crossover, comparative bioavailability study conducted in 40 healthy female subjects. All subjects received both treatments for 28 days in each of two periods, separated by a 28 days washout...
January 16, 2018: European Journal of Contraception & Reproductive Health Care
https://www.readbyqxmd.com/read/29336208/the-effects-of-sex-differences-and-hormonal-contraception-on-outcomes-following-collegiate-sports-related-concussion
#9
Virginia Terwilliger Gallagher, Natalie Kramer, Kristin Abbott, John Alexander, Hans Breiter, Amy Herrold, Tory Lindley, Jeffrey Mjaanes, James Reilly
There is conflicting evidence regarding whether females are more adversely affected following concussion relative to males. Further, recent research suggests hormonal contraceptive (HC) use may affect symptom severity and duration post-concussion. The objective of this study was to examine the effects of sex and HC use on outcomes following concussion among collegiate varsity athletes. We hypothesized females would have longer length of recovery (LOR) and peak symptom severity would be associated with longer length of recovery in both males and females...
January 16, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29334191/exogenous-oestrogen-inhibits-genital-transmission-of-cell-associated-hiv-1-in-dmpa-treated-humanized-mice
#10
Nirk E Quispe Calla, Rodolfo D Vicetti Miguel, Melissa E Glick, Jesse J Kwiek, Janelle M Gabriel, Thomas L Cherpes
INTRODUCTION: HIV affects more women than any other life-threatening infectious agent, and most infections are sexually transmitted. HIV must breach the female genital tract mucosal barrier to establish systemic infection, and clinical studies indicate virus more easily evades this barrier in women using depot-medroxyprogesterone acetate (DMPA) and other injectable progestins for contraception. Identifying a potential mechanism for this association, we learned DMPA promotes susceptibility of wild-type mice to genital herpes simplex virus type 2 (HSV-2) infection by reducing genital tissue expression of the cell-cell adhesion molecule desmoglein-1 (DSG-1) and increasing genital mucosal permeability...
January 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29329494/contraceptive-use-over-five-years-after-receipt-or-denial-of-abortion-services
#11
Heidi Moseson, Diana Greene Foster, Ushma D Upadhyay, Eric Vittinghoff, Corinne H Rocca
CONTEXT: Nonuse and inconsistent use of contraceptives contribute to a high incidence of unintended pregnancy and abortion among U.S. women. Little is known, however, about how these outcomes shape women's subsequent contraceptive use and unintended pregnancy risk. METHODS: Contraceptive use was examined among 880 participants in the Turnaway Study, a five-year longitudinal study of women who sought abortions at 30 U.S. facilities in 2008-2010. Multivariable mixed-effects logistic and multinomial regression models assessed differences in use by whether women received the abortion; results were used to calculate predicted percentages of women using each method...
January 12, 2018: Perspectives on Sexual and Reproductive Health
https://www.readbyqxmd.com/read/29328511/stigma-and-unmet-sexual-and-reproductive-health-needs-among-international-migrant-sex-workers-at-the-mexico-guatemala-border
#12
Teresita Rocha-Jiménez, Sonia Morales-Miranda, Carmen Fernández-Casanueva, Kimberly Brouwer, Shira M Goldenberg
OBJECTIVE: To explore international migrant sex workers' experiences and narratives pertaining to the unmet need for and access to sexual and reproductive health (SRH) at the Mexico-Guatemala border. METHODS: An inductive qualitative analysis was conducted based on ethnographic fieldwork (2012-2015) including participant observation and audio-recorded in-depth interviews. The participants were female sex workers aged 18 years or older and international migrants working at the Mexico-Guatemala border...
January 12, 2018: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29322301/effects-of-short-term-dhea-intake-on-hormonal-responses-in-young-recreationally-trained-athletes-modulation-by-gender
#13
Katia Collomp, Corinne Buisson, Nicolas Gravisse, Soraya Belgherbi, Zakaria Labsy, Manh-Cuong Do, Olivier Gagey, Sophie Dufay, Nancy Vibarel-Rebot, Michel Audran
BACKGROUND: Dehydroepiandrosterone (DHEA) figures on the World Anti-Doping Agency list of prohibited substances in sport because it is assumed that athletes expect a significant increase in testosterone through DHEA administration. The literature on the hormonal effects of DHEA intake nevertheless appears to be very scant in healthy young subjects, especially women. PURPOSE: We examined the effects of DHEA on adrenal and gonadal hormones, IGF1 and free T3 in healthy young male and female recreationally trained volunteers...
January 10, 2018: Endocrine
https://www.readbyqxmd.com/read/29318600/modern-contraceptive-use-among-women-living-with-hiv-aids-at-the-korle-bu-teaching-hospital-in-ghana
#14
Ali Samba, Kareem Mumuni, Joseph A Adu, Promise E Sefogah, William Kudzi, Edmund T Nartey
OBJECTIVE: To examine factors influencing contraceptive use among women living with HIV/AIDS. METHODS: The present cross-sectional study included a randomly selected sample of sexually active females aged 15-60 years who were living with HIV/AIDS and receiving care at the HIV Clinic, Korle Bu Teaching Hospital, Accra, Ghana, between September 1 and November 31, 2016. Data were collected via a structured interviewer-administered questionnaire. RESULTS: Among 202 women who completed the survey, 50 (24...
January 9, 2018: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29310654/pattern-and-determinants-of-contraceptive-usage-among-women-of-reproductive-age-from-the-digo-community-residing-in-kwale-kenya-results-from-a-cross-sectional-household-survey
#15
Vernon Mochache, Amyn Lakhani, Hajara El-Busaidy, Marleen Temmerman, Peter Gichangi
BACKGROUND: Contraceptive usage has been associated with improved maternal and child health (MCH) outcomes. Despite significant resources being allocated to programs, there has been sub-optimal uptake of contraception, especially in the developing world. It is important therefore, to granulate factors that determine uptake and utilization of contraceptive services so as to inform effective programming. METHODS: Between March and December 2015, we conducted a cross-sectional survey among women of reproductive age (WRA) from the Digo community residing in Kwale County, Kenya...
January 8, 2018: BMC Women's Health
https://www.readbyqxmd.com/read/29302853/progesterone-receptor-pgr-gene-variants-associated-with-breast-cancer-and-associated-features-a-case-control-study
#16
Rabeb M Ghali, Maryam A Al-Mutawa, Bashayer H Ebrahim, Hanen H Jrah, Sonia Zaied, Hanen Bhiri, Fahmi Hmila, Touhami Mahjoub, Wassim Y Almawi
Insofar as altered estrogen receptor-progesterone receptor (PR) expression contribute to breast cancer pathogenesis, previous studies examined the association of genetic variation in PR gene (PGR) with breast cancer, but with mixed outcome. We evaluated the association between PGR variants, and breast cancer and associated features. A retrospective case-control study involving 183 female breast cancer patients, and 222 control women. PGR genotyping was done by real-time PCR. Minor allele frequencies of rs1042838, rs590688, and rs10895068 PGR gene polymorphisms were significantly higher in breast cancer patients compared to controls...
January 4, 2018: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/29294796/college-women-s-experiences-of-male-partner-contraceptive-interference-associations-with-intimate-partner-violence-and-contraceptive-outcomes
#17
Jennifer Katz, Melissa A Sutherland
Many young adult women experience interpersonal barriers to protecting their sexual health. The focus of the current study was on contraceptive interference (CI), defined as partner behaviors that prevent effective contraception use before or during sex. We investigated whether CI tends to co-occur with intimate partner violence (IPV) and whether past CI is negatively associated with women's contraceptive outcomes. We also investigated perceived reasons for partner CI. Data were collected from sexually active female undergraduates ( N = 146) who had ended a (hetero)sexual relationship lasting at least 1 month...
June 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29294705/an-examination-of-domestic-violence-advocates-responses-to-reproductive-coercion
#18
Sara A McGirr, Heather D Bomsta, Cortney Vandegrift, Katie Gregory, Beth Ann Hamilton, Cris M Sullivan
Reproductive coercion (RC) is a form of intimate partner violence (IPV) that continues to lack adequate attention by both researchers and practitioners. RC is defined as "male partners' attempts to promote pregnancy in their female partners through verbal pressure and threats to become pregnant (pregnancy coercion), direct interference with contraception (birth control sabotage), and threats and coercion related to pregnancy continuation or termination (control of pregnancy outcomes)." This type of partner violence can have serious consequences on a survivor's health and well-being...
April 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29287491/acute-pulmonary-embolism-after-arthroscopic-glenoid-labral-repair-and-subacromial-decompression-case-report-and-review-of-the-literature
#19
Michelle Yagnatovsky, Amos Z Dai, Michael Zacchilli, Laith M Jazrawi
A 29-year-old female with a history of polycystic ovary syndrome (PCOS) on combined oral contraceptives presents with an acute, CT confirmed pulmonary embolus of the right lower lobe one week following arthroscopic labral repair of the right shoulder. The patient's risk factors including obesity, oral contraceptive use, PCOS, and surgical positioning are discussed.
December 21, 2017: Physician and Sportsmedicine
https://www.readbyqxmd.com/read/29284697/jordan-s-2002-to-2012-fertility-stall-and-parallel-usaid-investments-in-family-planning-lessons-from-an-assessment-to-guide-future-programming
#20
Esther Spindler, Nisreen Bitar, Julie Solo, Elizabeth Menstell, Dominick Shattuck
Health practitioners, researchers, and donors are stumped about Jordan's stalled fertility rate, which has stagnated between 3.7 and 3.5 children per woman from 2002 to 2012, above the national replacement level of 2.1. This stall paralleled United States Agency for International Development (USAID) funding investments in family planning in Jordan, triggering an assessment of USAID family planning programming in Jordan. This article describes the methods, results, and implications of the programmatic assessment...
December 28, 2017: Global Health, Science and Practice
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