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https://www.readbyqxmd.com/read/28210634/potential-of-a-pharmacogenetic-guided-algorithm-to-predict-optimal-warfarin-dosing-in-a-high-risk-hispanic-patient-role-of-a-novel-nqo1-2-polymorphism
#1
Dagmar F Hernandez-Suarez, Karla Claudio-Campos, Javier E Mirabal-Arroyo, Bianca A Torres-Hernández, Angel López-Candales, Kyle Melin, Jorge Duconge
Deep abdominal vein thrombosis is extremely rare among thrombotic events secondary to the use of contraceptives. A case to illustrate the clinical utility of ethno-specific pharmacogenetic testing in warfarin management of a Hispanic patient is reported. A 37-year-old Hispanic Puerto Rican, non-gravid female with past medical history of abnormal uterine bleeding on hormonal contraceptive therapy was evaluated for abdominal pain. Physical exam was remarkable for unspecific diffuse abdominal tenderness, and general initial laboratory results-including coagulation parameters-were unremarkable...
October 2016: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/28205046/reproductive-factors-and-risk-of-colorectal-polyps-in-a-colonoscopy-based-study-in-western-washington-state
#2
Sheetal Hardikar, Andrea N Burnett-Hartman, Jessica Chubak, Melissa P Upton, Lee-Ching Zhu, John D Potter, Polly A Newcomb
BACKGROUND: Oral contraceptives (OC) are associated with a decreased risk of colorectal cancers; however, a recent study reported an increased risk of small colorectal adenomas associated with OC use. To determine if these results were replicable in a different study population, we investigated the relationship between OC use and other reproductive factors and risk of colorectal polyps in a case-control study in western Washington. METHODS: Study participants were 24-79-year-old female enrollees at an integrated health care system in western Washington who were diagnosed as having adenomas (n = 299), serrated polyps (n = 337), both types of polyps (n = 105) or as polyp-free controls (n = 615) through an index colonoscopy and completed a structured interview to collect reproductive history information...
February 15, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28191316/the-contraceptive-efficacy-of-intravas-injection-of-vasalgel%C3%A2-for-adult-male-rhesus-monkeys
#3
Angela Colagross-Schouten, Marie-Josee Lemoy, Rebekah I Keesler, Elaine Lissner, Catherine A VandeVoort
BACKGROUND: Options for male contraception are limited. The purpose of this study was to use a nonhuman primate model to evaluate Vasalgel™, a high molecular weight polymer being developed as a contraceptive device for men. METHODS: Sixteen adult male rhesus monkeys received intravas injections of Vasalgel, consisting of 25% styrene maleic acid in dimethyl sulfoxide. After a one-week recovery, males were returned to outdoor group housing, which included at least 3 and up to 9 intact, breeding females with a successful reproductive history...
2017: Basic and Clinical Andrology
https://www.readbyqxmd.com/read/28179523/progesterone-based-contraceptives-reduce-adaptive-immune-responses-and-protection-against-sequential-influenza-a-virus-infections
#4
Olivia J Hall, Raffael Nachbagauer, Meghan S Vermillion, Ashley L Fink, Vanessa Phuong, Florian Krammer, Sabra L Klein
In addition to their intended use, progesterone (P4)-based contraceptives promote anti-inflammatory immune responses, yet their effects on the outcome of infectious diseases, including influenza A virus (IAV), are rarely evaluated. To evaluate their impact on immune responses to sequential IAV infections, adult female mice were treated with placebo or one of two progestins, P4 or levonorgestrel (LNG), and infected with mouse adapted (ma) H1N1 virus. Treatment with P4 or LNG reduced morbidity, but had no effect on pulmonary virus titers, during primary H1N1 infection as compared to placebo treatment...
February 8, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28176338/effects-of-neonatal-17%C3%AE-ethinyloestradiol-exposure-on-female-paced-mating-behaviour-in-the-rat
#5
Chiaki Komine, Shingo Nakajima, Yasuhiko Kondo, Yasuyuki Horii, Midori Yoshida, Maiko Kawaguchi
Correct perinatal oestrogen levels are critical for sexual differentiation. For example, perinatal exposure to oestrogen causes masculinization and defeminization of the brain in female rats and also induces delayed effects after maturation characterized by early onset of abnormal oestrus cycling. However, the mechanisms underlying the above effects of oestrogen remain to be fully determined. 17α-ethinyloestradiol (EE), a common synthetic oestrogen widely used in oral contraceptives, binds specifically to oestrogen receptors...
February 8, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28166594/influence-of-dyslipidemia-on-the-quality-of-sexual-life-in-women-in-the-menacme-using-a-combined-oral-contraceptive
#6
Rodolfo Strufaldi, Luciano Melo Pompei, Marcelo Luis Steiner, César Eduardo Fernandes
Purpose Female sexual dysfunction is a complex and common condition that affects women, and the relationship between sexual function and dyslipidemia is poorly studied. This study aims to assess this relationship in the reproductive life women in the menacme who use combined oral contraceptives (COCs). Methods A total of 49 healthy women who were sexually active received COC pills that contained ethinylestradiol 30 mcg (EE30) plus levonorgestrel 150 mcg (LNG150). The women were divided into two groups according to their lipid profiles...
December 2016: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/28163962/high-dose-of-green-tea-infusion-normalized-spiral-artery-density-in-rats-treated-with-the-depot-medroxyprogesterone-acetate
#7
A S Emilda, Nora Veri, Alchalidi Alchalidi
AIM: The purpose of this study was to investigate the effects of green tea (GT) on the spiral artery density and endometrial thickness in female rats treated with the depot-medroxyprogesterone acetate (DMPA). MATERIAL AND METHODS: A total of 24 female rats were randomly divided into four groups (n = 6 each): The control group (no treatment), the DMPA-treated group, treated with DMPA and GT doses of 165 mg/kg of body weight/day, and treated with DMPA and GT doses of 330 mg/kg of body weight/day...
January 2017: Journal of Intercultural Ethnopharmacology
https://www.readbyqxmd.com/read/28158181/platelet-full-length-tfpi-%C3%AE-in-healthy-volunteers-is-not-affected-by-sex-or-hormonal-use
#8
Kristien Winckers, Stella Thomassen, Hugo Ten Cate, Tilman M Hackeng
BACKGROUND: Only 10% of plasma TFPIα (TFPI) exists in the full length form, the rest circulates as a C-terminally truncated form. However, blood platelets exclusively contain full length TFPI, which is released at the site of injury upon platelet activation, and which could play an important local regulatory role in thrombin generation and prevention of thrombosis. METHODS: The anticoagulant activities of full length and truncated TFPI were investigated using thrombin generation assays...
2017: PloS One
https://www.readbyqxmd.com/read/28155090/oral-spironolactone-for-acne-vulgaris-in-adult-females-a-hybrid-systematic-review
#9
REVIEW
Alison M Layton, E Anne Eady, Heather Whitehouse, James Q Del Rosso, Zbys Fedorowicz, Esther J van Zuuren
BACKGROUND: The management of acne in adult females is problematic, with many having a history of treatment failure and some having a predisposition to androgen excess. Alternatives to oral antibiotics and combined oral contraceptives (COCs) are required. OBJECTIVE: Our aim was to conduct a hybrid systematic review of the evidence for benefits and potential harms of oral spironolactone in the management of acne in adult females. METHODS: The review was conducted according to a previously published protocol...
February 2, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28153992/anti-m%C3%A3-llerian-hormone-trajectories-are-associated-with-cardiovascular-disease-in-women-results-from-the-doetinchem-cohort-study
#10
Annelien C de Kat, W Monique Verschuren, Marinus J C Eijkemans, Frank J M Broekmans, Yvonne T van der Schouw
BACKGROUND: Earlier age at menopause is widely considered to be associated with an increased risk of cardiovascular disease. However, the underlying mechanisms of this relationship remain undetermined. Indications suggest that anti-Müllerian hormone (AMH), an ovarian reserve marker, plays a physiological role outside of the reproductive system. Therefore, we investigated whether longitudinal AMH decline trajectories are associated with an increased risk of cardiovascular disease (CVD) occurrence...
February 7, 2017: Circulation
https://www.readbyqxmd.com/read/28152966/analysis-of-the-results-of-implementation-of-a-pregnancy-screening-policy-at-a-comprehensive-cancer-center
#11
David Cleveland, Alma Yvette DeJesus, Lee Cheng, Elizabeth Ann Wagar, Charles F Levenback, Maria Alma Rodriguez
: 256 Background: Institutional implementation of a standard pregnancy screening policy for women will enhance the safe and timely delivery of treatment throughout the care continuum. In 2012, we developed and implemented an initial policy on pregnancy screening test (PST). The policy indicated that all providers should fully discuss with their female patients of child bearing potential regarding the potential risks of cancer treatment on fertility and the adverse effects on the fetus...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28132745/associations-between-sex-education-and-contraceptive-use-among-heterosexually-active-adolescent-males-in-the-united-states
#12
Nicole Jaramillo, Eric R Buhi, John P Elder, Heather L Corliss
PURPOSE: This study examined associations between reports of receiving education on topics commonly included in sex education (e.g., abstinence only, comprehensive) prior to age 18 years and contraceptive use at the last sex among heterosexually active, 15- to 20-year-old males in the United States. METHODS: Cross-sectional data from 539 males participating in the 2011-2013 National Survey of Family Growth were analyzed. Bivariate and multinomial logistic regression analyses adjusting for confounding estimated associations between receipt of seven sex education topics (e...
January 26, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28129717/improvement-of-migraine-with-change-from-combined-hormonal-contraceptives-to-progestin-only-contraception-with-desogestrel-how-strong-is-the-effect-of-taking-women-off-combined-contraceptives
#13
Gabriele S Merki-Feld, Bruno Imthurn, Raghvendran Dubey, Peter S Sándor, Andreas R Gantenbein
Migraine is a disabling headache disorder, which affects up to 17% of the female population. Oestrogen withdrawal during the menstrual cycle or the hormone-free interval in users of combined hormonal contraceptives (CHC) plays a pivotal role. Two diary-based studies demonstrated a positive impact of the progestin-only pill (POP) desogestrel 75 μg on the frequency of the migraine attacks and pain intensity. In both studies, CHC users as well as nonusers were included, which makes it difficult to distinguish between the effect of taking women off the CHC and the benefit of the POP itself...
January 27, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28123251/nonpalpable-intrauterine-device-threads-is-it-a-cause-for-worry
#14
S K Kathpalia, M K Singh, D S Grewal
BACKGROUND: Intrauterine contraceptive device is a popular and effective method of contraception. It can be inserted either as an interval procedure or after abortion or delivery. Threads are attached to the vertical limb so that the user can find out the location of the device. Sometimes the threads are not palpable by the user; this study was conducted to find out the reasons for inability to palpate the threads. METHODS AND RESULTS: The retrospective study was conducted over a period of eight years; 110 female patients who complained of inability to feel the threads were included in the study...
January 2017: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/28115500/smoking-behavior-change-during-compulsory-military-service-in-israel-1987-2011
#15
Salman Zarka, Hagai Levine, Vladislav Rozhavski, Tamar Sela, Yael Bar-Ze'ev, Vered Molina-Hazan, Laura J Rosen
INTRODUCTION: Smoking in military settings is of major concern. We aimed to assess the association between personal, family, and military factors and smoking behavior change during compulsory military service in Israel. METHODS: Participants were soldiers recruited between 1987 and 2008 who were interviewed at recruitment and reinterviewed at discharge (1987-2011) (total: 29 189; males:15 136; females:14 053). The primary outcome variables were smoking initiation during service among nonsmokers at recruitment, and cessation during service among smokers at recruitment...
January 23, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28114813/reproductive-health-counseling-delivered-to-women-living-with-hiv-in-the-united-states
#16
Runa H Gokhale, Heather Bradley, John Weiser
Advances in antiretroviral therapy (ART) and reproductive technologies have made transmission of HIV to partners and infants almost completely preventable. Comprehensive reproductive health counseling (CRHC) is an important component of care for women living with HIV, but few women report discussing reproductive health with an HIV care provider. We surveyed a probability sample of U.S. HIV care providers during 2013-2014. Of 2023 eligible providers, 1234 responded (64% adjusted provider response rate). We estimated the percentage delivering CRHC to their female patients...
January 23, 2017: AIDS Care
https://www.readbyqxmd.com/read/28110980/female-sterilization-is-more-common-among-women-with-physical-and-or-sensory-disabilities-than-women-without-disabilities-in-the-united-states
#17
Justine P Wu, Michael M McKee, Kimberly S Mckee, Michelle A Meade, Melissa Plegue, Ananda Sen
BACKGROUND: Female sterilization accounts for 50% of all contraceptive use in the U.S. The extent to which U.S. women with physical and/or sensory disabilities have undergone female sterilization is unknown. OBJECTIVE: Our primary objective was to determine the prevalence of sterilization for women with physical/sensory disabilities, and compare this to the prevalence for women without disabilities. We also compared use of long-acting reversible contraceptive (LARC) methods between women with and without disabilities...
January 3, 2017: Disability and Health Journal
https://www.readbyqxmd.com/read/28108026/parity-infertility-oral-contraceptives-and-hormone-replacement-therapy-and-the-risk-of-ovarian-serous-borderline-tumors-a-nationwide-case-control-study
#18
Emma L Kaderly Rasmussen, Charlotte Gerd Hannibal, Christian Dehlendorff, Louise Baandrup, Jette Junge, Russell Vang, Robert J Kurman, Susanne K Kjaer
OBJECTIVE: Few studies have examined the risk of an ovarian serous borderline tumor (SBT) associated with parity, infertility, oral contraceptives (OCs), or hormone replacement therapy (HRT), which was the study aim. METHODS: This nationwide case-control study included all women with an SBT diagnosis in Denmark, 1978-2002. SBTs were confirmed by centralized expert pathology review. For each case, 15 age-matched female controls were randomly selected using risk-set sampling...
January 17, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28107821/effects-of-a-single-20%C3%A2-mg-dose-of-letrozole-on-ovarian-function-post-dominant-follicle-selection-an-exploratory-randomized-controlled-trial
#19
H C M Allaway, D R Chizen, G P Adams, R A Pierson
BACKGROUND: Our objective was to explore the impact of a single dose of an aromatase inhibitor (letrozole) administered at defined times of the follicular phase or immediately after ovulation on dominant follicle development, luteogenesis and new follicle wave emergence. METHODS: A prospective pilot study using a randomized complete block, controlled, open label design was conducted at an academic clinical research center. Forty-five healthy, female volunteers (25...
January 21, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28107371/sexual-reproductive-health-needs-and-rights-of-young-people-in-slum-areas-of-kampala-uganda-a-cross-sectional-study
#20
Andre M N Renzaho, Joseph K Kamara, Nichole Georgeou, Gilbert Kamanga
BACKGROUND: Young people in Uganda face various sexual and reproductive health risks, especially those living in urban slums. The aim of this study was to examine factors associated with comprehensive categories of sexual and reproductive health, including sexual behaviours; sexual education and access to contraceptive services; family planning; prevention of STDs; sexual consent as a right; gender based violence; as well as HIV testing, counselling, disclosure and support. METHODS: The study was cross-sectional in design and was carried out in July 2014 in Makindye and Nakawa Divisions of Kampala City, Uganda...
2017: PloS One
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