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https://www.readbyqxmd.com/read/27704220/a-review-of-the-safety-of-clozapine-during-pregnancy-and-lactation
#1
Taylor M Mehta, Ryan J Van Lieshout
Clozapine is an antipsychotic used in the management of treatment-resistant schizophrenia. However, little is known about clozapine use during pregnancy and lactation, or its impact on the mother, foetus, and infant. This review aims to summarize the available literature on the safety of clozapine use during the perinatal period. EMBASE, PsycINFO, and MEDLINE were searched from their inceptions through June 2016. The review encompasses 21 studies that have examined clozapine use during pregnancy and lactation...
October 4, 2016: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/27610443/overcoming-challenges-faced-by-breastfeeding-mothers
#2
Lisa H Amir, Anita Bearzatto
BACKGROUND: Women who are breastfeeding often consult their general practitioner (GP) with concerns about nipple and breast pain, or the adequacy of their milk supply. Common concerns for their breastfed infant include slow weight gain, 'fussiness' with breastfeeding and 'funny stools'. OBJECTIVE: This article offers suggestions for clinicians to support breastfeeding women and their infants. DISCUSSION: Good attachment to the breast is important to reduce nipple pain and trauma, and to ensure adequate breast drainage and ongoing milk supply...
August 2016: Australian Family Physician
https://www.readbyqxmd.com/read/27573672/-affective-disorders-during-pregnancy-therapy-with-antidepressants-and-mood-stabilizers
#3
N Bergemann, W E Paulus
BACKGROUND: It is not rare that the first manifestation or relapse of an affective disorder occurs during pregnancy. Should a pharmacological treatment be indicated, the selection of a suitable substance should be made on a basis which is as safe as possible. Even when treating women of childbearing age it should be assured that the psychotropic drug selected is safe to use during pregnancy as a high percentage of pregnancies are unplanned. OBJECTIVE: When assessing the risks and benefits of psychopharmacotherapy in women who are or wish to get pregnant, not only the exposure of the child to potentially teratogenic drug effects but also potential complications during or after pregnancy and long-term neuropsychological issues need to be addressed...
September 2016: Der Nervenarzt
https://www.readbyqxmd.com/read/27568278/mood-stabilizers-and-antipsychotics-during-breastfeeding-focus-on-bipolar-disorder
#4
REVIEW
Isabella Pacchiarotti, Jordi León-Caballero, Andrea Murru, Norma Verdolini, Maria Antonietta Furio, Corinna Pancheri, Marc Valentí, Ludovic Samalin, Eva Solé Roigé, Ana González-Pinto, Jose Manuel Montes, Antonio Benabarre, Jose Manuel Crespo, Consuelo de Dios Perrino, Jose Manuel Goikolea, Luis Gutiérrez-Rojas, André F Carvalho, Eduard Vieta
Breast milk is considered the best source of nutrients and provides much better protection than immune modified milk. However, the postpartum period is a phase of increased risk for all women to experience psychiatric symptoms and recurrences or new episodes of bipolar disorder (BD), especially in those who have discontinued treatment. This is a systematic review of the risks and benefits of mood stabilizers and antipsychotics during breastfeeding as they relate to the health and well-being of mothers and their infants...
October 2016: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27535132/improving-access-to-medical-lactation-support-and-counseling-building-the-case-for-medicaid-reimbursement
#5
Kathryn Wouk, Ellen Chetwynd, Thomas Vitaglione, Catherine Sullivan
Objective While the Affordable Care Act improves access to lactation services for many women across the US, low-income mothers in states without Medicaid expansion lack coverage for lactation support. As these states consider individual Medicaid reimbursement policies, the availability, effectiveness, and cost-benefit of lactation services must be evaluated. We conducted such an analysis for low-income mothers in North Carolina (NC), providing a model for other states. Methods First, we analyzed the distribution of NC International Board Certified Lactation Consultants (IBCLCs) and county-level breastfeeding rates among low-income infants...
August 17, 2016: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/27533332/the-relationship-between-infant-feeding-outcomes-and-maternal-emotional-well-being-among-mothers-of-late-preterm-and-term-infants-a-secondary-exploratory-analysis
#6
Kristin P Tully, Diane Holditch-Davis, Susan Silva, Debra Brandon
BACKGROUND: Late preterm birth is associated with lower rates of breastfeeding and earlier breastfeeding cessation than term birth. PURPOSE: The objectives of this secondary analysis were to compare the incidence of exclusive breastfeeding after late preterm and term childbirth and to examine the association between infant feeding outcomes and maternal emotional well-being. METHODS: Participants were 105 mother-infant dyads (54 late preterm and 51 term) at a southeastern US medical center...
August 16, 2016: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
https://www.readbyqxmd.com/read/27522863/preterm-human-milk-composition-a-systematic-literature-review
#7
Catherine Boyce, Mistral Watson, Grace Lazidis, Sarah Reeve, Kenneth Dods, Karen Simmer, Gemma McLeod
There are wide variations in the macronutrient values adopted by neonatal intensive care units and industry to fortify milk in efforts to achieve recommended intakes for preterm infants. Contributing to this is the variation in macronutrient composition of preterm milk between and within mothers and the variable quality of milk analyses used to determine the macronutrient content of milk. We conducted a systematic review of the literature using articles published in English between 1959 and 2013 that reported the concentrations of one or more macronutrients or energy content in human preterm milk, sampled over a representative 24-h period...
September 2016: British Journal of Nutrition
https://www.readbyqxmd.com/read/27514147/-the-role-of-mother-s-milk-and-breast-feeding-medical-problems-during-the-lactation-period-lactobacilus-fermentum-a-new-approach-towards-the-prevention-and-the-treatment-of-acute-and-subacute-mastitis
#8
B Popova, D Mitev, A Nikolov
Breast feeding provides a lot of short and long-term benefits for the mother and the baby. It prevents the baby of gastrointestinal, urinary and respiratory infections, atopical conditions and assures long-term protection of cardiovascular and metabolic diseases. The breast feeding decreases the risk for the mother of ovary and breast carcinoma and creates a positive emotional bond between the mother and the baby Mother's milk is a species specific; its content is relatively stable regardless of mother's age race, way and place of living...
2016: Akusherstvo i Ginekologii︠a︡
https://www.readbyqxmd.com/read/27497651/development-and-validation-of-a-bioanalytical-method-for-five-antidepressants-in-human-milk-by-lc-ms
#9
Fernanda Rodrigues Salazar, Felipe Bianchini D'Avila, Marcella Herbstrith de Oliveira, Pamela Lukasewicz Ferreira, Ana Maria Bergold
The use of medications during lactation is a common practice; however, pharmacological treatments impose serious doubts to both professionals and nursing mothers regarding the safety of drugs used during this period. Most of drugs are excreted in breast milk and there is great variability in the amount of analytes that can be received by the infant. Dilemmas about breastfeeding arise most commonly in relation to postpartum depression. Depression is a major clinical problem during the postpartum period and the vulnerability to onset or recurrence of depressive symptoms increases the possibility of psychotropic drug use during lactation...
September 10, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/27444764/perianesthetic-considerations-for-the-breastfeeding-mother
#10
Amber Brook Smathers, Shawn Collins, Ian Hewer
Breastfeeding has been shown to be beneficial in the development of infants, but sometimes, the breastfeeding mother may require anesthesia. It is important for perianesthesia caregivers to understand how the breastfed infant may be affected by the anesthetic medications received by the breastfeeding mother. This article reviews current literature on drug transfer into breast milk and specifically how anesthetic drugs may affect breastfed infants. The pharmacokinetics of drug transfer during lactation is described as well as considerations for perianesthesia providers when caring for breastfeeding patients...
August 2016: Journal of Perianesthesia Nursing: Official Journal of the American Society of PeriAnesthesia Nurses
https://www.readbyqxmd.com/read/27418219/early-postpartum-lactation-effects-of-cesarean-and-vaginal-birth
#11
Yuksel İsik, Zeynep O Dag, Ozlem B Tulmac, Eren Pek
OBJECTIVES: Breastfeeding has positive effects for both, the mother and the infant. The purpose of the study was to ex-amine how cesarean delivery and vaginal delivery influenced subsequent breastfeeding. The study was conducted at the Kırıkkale University Medical School. MATERIAL AND METHODS: Breastfeeding outcomes after an elective cesarean delivery and after a planned vaginal delivery were compared. The study included 169 consenting mothers who gave birth to healthy infants (86 cesarean deliveries and 83 vaginal deliveries) between March and September 2001...
2016: Ginekologia Polska
https://www.readbyqxmd.com/read/27412890/association-between-gestational-weight-gain-and-risk-of-obesity-in-preadolescence-a-longitudinal-study-1997-2007-of-5125-children-in-greece
#12
S P Mourtakos, K D Tambalis, D B Panagiotakos, G Antonogeorgos, C D Alexi, M Georgoulis, G Saade, L S Sidossis
BACKGROUND: The present study aimed to investigate the association between gestational weight gain (GWG) and birth weight, as well as the body mass index (BMI) status, of children at the ages of 2 and 8 years. METHODS: Population-based data were obtained from a database of all 7-9-year-old Greek children who attended primary school during 1997-2007. The study sample consisted of 5125 children matched with their mothers, randomly selected according to region and place of residence, and equally distributed (approximately 500 per year) throughout the study period (1997-2007)...
July 14, 2016: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://www.readbyqxmd.com/read/27401570/detectable-tenofovir-levels-in-breast-feeding-infants-of-mothers-exposed-to-topical-tenofovir
#13
Lisa M Noguchi, Elizabeth T Montgomery, Joseph R Biggio, Craig W Hendrix, Debra L Bogen, Sharon L Hillier, James Y Dai, Jeanna M Piper, Mark A Marzinke, Charlene S Dezzutti, S Karen Isaacs, Jill L Schwartz, D Heather Watts, Richard H Beigi
Lactation studies are necessary evaluations of medications for reproductive-age women. We evaluated pharmacokinetics (PK), pharmacodynamics, safety, and adherence profiles associated with 7 days of 1% tenofovir (TFV) vaginal gel use during lactation. Tenofovir levels (maternal/infant serum, milk) and anti-HIV activity (milk), adverse events (AEs), and adherence were measured for 17 HIV-1-seronegative breast-feeding mother-infant pairs. Tenofovir use was well-tolerated and detected at low levels in maternal serum, milk, and infant serum but demonstrated no anti-HIV activity in milk...
September 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27350011/maternal-dietary-folate-folic-acid-and-vitamin-d-intakes-during-pregnancy-and-lactation-and-the-risk-of-cows-milk-allergy-in-the-offspring
#14
Jetta Tuokkola, Päivi Luukkainen, Minna Kaila, Hanna-Mari Takkinen, Sari Niinistö, Riitta Veijola, Lauri J Virta, Mikael Knip, Olli Simell, Jorma Ilonen, Suvi M Virtanen
Maternal nutrient intake during pregnancy and lactation potentially influences the development of allergic diseases. Cows' milk allergy (CMA) is often the first manifestation of atopic diseases, but the impact of early nutritional influences on CMA has not been explored. The associations between maternal intakes of folate, folic acid and vitamin D during pregnancy and lactation were addressed in a prospective, population-based birth cohort within the Finnish Type 1 Diabetes Prediction and Prevention Study. Mothers of 4921 children during pregnancy and 2940 children during lactation provided information on maternal dietary intake during the 8th month of pregnancy and the 3rd month of lactation using a detailed, validated FFQ...
August 2016: British Journal of Nutrition
https://www.readbyqxmd.com/read/27313273/breast-pain-in-lactating-mothers
#15
S Sf Leung
INTRODUCTION: The number of new mothers who breastfeed has increased dramatically over the last three decades. There is a concern that the present related medical service may be inadequate. Breast pain is the most common complaint among lactating mothers who seek medical help. This study aimed to investigate this problem. METHODS: Medical records of women who presented with breast pain to a private clinic run by a doctor who was trained as an International Lactation Consultant were reviewed over a period of 6 months in 2015...
August 2016: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/27297803/pharmacological-lactation-suppression-with-d2-receptor-agonists-and-risk-of-postpartum-psychosis-a-systematic-review
#16
REVIEW
Martien Snellen, Josephine Power, Gaynor Blankley, Megan Galbally
BACKGROUND: It has been suggested that D2 receptor agonists commonly used postpartum for the physiological suppression of lactation, such as bromocriptine and cabergoline, may increase the risk of illness onset or relapse in women where there is a predisposition for or history of schizophrenia, bipolar disorder or postpartum psychosis. This is based on two lines of reasoning: current models of psychosis assume episodes are triggered by dysregulation of brain dopaminergic activity and treated by medications that universally have D2 receptor antagonist properties; and limited research suggesting these agents may be associated with psychotic episodes in vulnerable individuals outside of the postpartum period...
August 2016: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/27272612/mother-and-child-medication-use-in-pregnancy-and-lactation
#17
S Ito
Pregnancy and breastfeeding pose a unique challenge to drug development and clinical application. In addition to drug toxicity to the fetus in utero and infants through breastfeeding, alterations of pharmacokinetics in those women also need careful attention. How do we turn around the overall lack of drug efficacy and toxicity information for pregnant and breastfeeding women?
July 2016: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27067707/risk-factors-predicting-infectious-lactational-mastitis-decision-tree-approach-versus-logistic-regression-analysis
#18
Leónides Fernández, Pilar Mediano, Ricardo García, Juan M Rodríguez, María Marín
Objectives Lactational mastitis frequently leads to a premature abandonment of breastfeeding; its development has been associated with several risk factors. This study aims to use a decision tree (DT) approach to establish the main risk factors involved in mastitis and to compare its performance for predicting this condition with a stepwise logistic regression (LR) model. Methods Data from 368 cases (breastfeeding women with mastitis) and 148 controls were collected by a questionnaire about risk factors related to medical history of mother and infant, pregnancy, delivery, postpartum, and breastfeeding practices...
September 2016: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/27045706/an-assessment-of-dioxin-exposure-across-gestation-and-lactation-using-a-pbpk-model-and-new-data-from-seveso
#19
C Emond, M DeVito, M Warner, B Eskenazi, P Mocarelli, L S Birnbaum
On July 10, 1976, an explosion at a chemical plant in Seveso, Italy, released up to 30kg of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-the most potent dioxin congener. Twenty years later, the Seveso Women's Health Study (SWHS) initiated a follow-up assessment of a cohort of female Seveso residents. Researchers collected serial blood, measured for TCDD levels, and recorded information about the women's medical history after the explosion. The study's aims were to: 1) modify the human PBPK model for TCDD (Emond et al...
July 2016: Environment International
https://www.readbyqxmd.com/read/27003478/ankyloglossia-and-the-breastfeeding-infant-assessment-and-intervention
#20
Christine Manipon
BACKGROUND: Our current culture defines breastfeeding and the use of human breast milk as the preferred criterion standard for infant nutrition. Medical and health professionals have a responsibility to support breastfeeding in the mother-infant dyad. This includes the recognition of anatomical barriers to breastfeeding such as a tongue-tie, ankyloglossia. PURPOSE: The purpose of this article is to enrich and expand the clinical knowledge of health professionals about the physical assessment of ankyloglossia and its impact on breastfeeding...
April 2016: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
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