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https://www.readbyqxmd.com/read/28091736/salvage-therapy-for-acute-chemorefractory-leukemia-by-allogeneic-stem-cell-transplantation-the-korean-experience
#1
Shin Hye Yoo, Youngil Koh, Dae-Young Kim, Jung-Hee Lee, Je-Hwan Lee, Kyoo-Hyung Lee, Sung-Soo Yoon, Seonyang Park, Sung-Kyu Park, Dae-Sik Hong, Hyeon Gyu Yi, Chul-Soo Kim, Ji Eun Jang, June-Won Cheong, Joonho Moon, Yoo Hong Min, Sang Kyun Sohn, Inho Kim
Little is known about the characteristics that make patients with acute leukemia suitable for undergoing salvage therapy by allogeneic hematopoietic stem cell transplantation (allo-HSCT). Here, we analyzed the clinical outcomes of 223 patients with acute leukemia who underwent allo-HSCT while not in complete remission (CR). The primary end points were overall survival (OS) and CR rate. CR was achieved in 79.8% of patients after allo-HSCT. Acute graft-versus-host disease (GVHD) was significantly associated with CR (P = 0...
January 16, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28090487/clinical-characteristics-and-outcomes-of-varicella-zoster-virus-infection-in-children-with-hematologic-malignancies-in-the-acyclovir-era
#2
Seul-Ki Kim, Min Chae Kim, Seung Beom Han, Seong Koo Kim, Jae Wook Lee, Nack-Gyun Chung, Bin Cho, Dae Chul Jeong, Jin Han Kang, Hack-Ki Kim
BACKGROUND: Although intravenous acyclovir therapy is recommended for varicella zoster virus (VZV) infection in immunocompromised children, the clinical characteristics and outcomes of VZV infection in the acyclovir era have rarely been reported. METHODS: The medical records of children diagnosed with varicella or herpes zoster virus, who had underlying hematologic malignancies, were retrospectively reviewed, and the clinical characteristics and outcomes of VZV infection were evaluated...
December 2016: Blood Research
https://www.readbyqxmd.com/read/28075154/survivorship-after-meniscal-allograft-transplantation-according-to-articular-cartilage-status
#3
Bum-Sik Lee, Seong-Il Bin, Jong-Min Kim, Won-Kyeong Kim, Jun Weon Choi
BACKGROUND: Clinical outcomes after meniscal allograft transplantation (MAT) in arthritic knees are unclear, and objective estimates of graft survival according to the articular cartilage status have not been performed. HYPOTHESIS: MAT should provide clinical benefits in knees with high-grade cartilage damage, but their graft survivorship should be inferior to that in knees with low-grade chondral degeneration after MAT. STUDY DESIGN: Cohort study; Level of evidence, 3...
January 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28073785/safety-and-efficacy-of-allogeneic-hematopoietic-stem-cell-transplant-after-pd-1-blockade-in-relapsed-refractory-lymphoma
#4
Reid W Merryman, Haesook T Kim, Pier Luigi Zinzani, Carmelo Carlo-Stella, Stephen M Ansell, Miguel-Angel Perales, Abraham Avigdor, Ahmad S Halwani, Roch Houot, Tony Marchand, Nathalie Dhedin, Willy Lescaut, Anne Thiebaut-Bertrand, Sylvie François, Aspasia Stamatoullas-Bastard, Pierre-Simon Rohrlich, Hélène Labussière Wallet, Luca Castagna, Armando Santoro, Veronika Bachanova, Scott C Bresler, Amitabh Srivastava, Harim Kim, Emily Pesek, Marie Chammas, Carol Reynolds, Vincent T Ho, Joseph H Antin, Jerome Ritz, Robert J Soiffer, Philippe Armand
Anti-PD-1 monoclonal antibodies are being increasingly tested in patients with advanced lymphoma. Following treatment, many of those patients are likely to be candidates for allogeneic hematopoietic stem cell transplant (HSCT). However, the safety and efficacy of HSCT may be affected by prior PD-1 blockade. We conducted an international retrospective analysis of 39 patients with lymphoma who received prior treatment with a PD-1 inhibitor, at a median time of 62 days (7-260) before HSCT. After a median follow-up of 12 months, the one-year cumulative incidences of grade 2-4 and grade 3-4 acute graft-versus-host disease (GVHD) were 44% and 23% respectively, while the one-year incidence of chronic GVHD was 41%...
January 10, 2017: Blood
https://www.readbyqxmd.com/read/28072739/risk-factors-and-outcomes-associated-with-a-higher-use-of-inotropes-in-kidney-transplant-recipients
#5
Jae Moon Choi, Jun-Young Jo, Jae-Won Baik, Sooyoung Kim, Chan Sik Kim, Sung-Moon Jeong
Preservation of adequate perfusion pressures to the graft is a main focus of intraoperative management during kidney transplantation. We undertook this study to investigate the incidence of the higher use of inotropes in kidney transplant recipients and identify the patient outcomes and preoperative and intraoperative variables related to this.We retrospectively analyzed 1053 patients who underwent kidney transplantation at Asan Medical Center between January 2006 and February 2012, stratified by their inotropic score ([dopamine] + [dobutamine] + [epinephrine × 100] + [norepinephrine × 100]) <7 versus ≥7, wherein all doses are expressed as μg/kg/min...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28068455/variation-in-access-to-kidney-transplantation-across-renal-programs-in-ontario-canada
#6
K L Naylor, S N Dixon, A X Garg, S J Kim, P G Blake, G E Nesrallah, M K McCallum, C D'Antonio, A H Li, G A Knoll
In the United States, kidney transplant rates vary significantly across end-stage renal disease (ESRD) networks. We conducted a population-based cohort study to determine whether there was variability in kidney transplant rates across renal programs in a health care system distinct from the United States. We included incident chronic dialysis patients in Ontario, Canada, from 2003 to 2013 and determined the 1-, 5-, and 10-year cumulative incidence of kidney transplantation in 27 regional renal programs (similar to U...
January 9, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28066607/risk-factors-and-outcome-of-primary-graft-dysfunction-after-lung-transplantation-in-korea
#7
Sungwoo Moon, Moo Suk Park, Jin Gu Lee, Ji Ye Jung, Young Ae Kang, Young Sam Kim, Se Kyu Kim, Joon Chang, Hyo Chae Paik, Song Yee Kim
BACKGROUND: Primary graft dysfunction (PGD) is a severe, acute and post-transplantation lung injury associated with early morbidity and mortality. We aimed to identify clinical risk factors for PGD, as well as the outcome of PGD after lung transplantation in Korea. METHODS: We retrospectively analyzed lung transplant patients in a South Korean Hospital. The primary outcome was grade 3 PGD, defined according to the International Society for Heart and Lung Transplantation criteria...
November 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28061460/l1-increases-adhesion-mediated-proliferation-and-chemoresistance-of-retinoblastoma
#8
Dong Hyun Jo, Kyungmin Lee, Jin Hyoung Kim, Hyoung Oh Jun, Younghoon Kim, Young-Lai Cho, Young Suk Yu, Jeong-Ki Min, Jeong Hun Kim
Retinoblastoma is the most common intraocular cancer in children, affecting 1/20,000 live births. Currently, children with retinoblastoma were treated with chemotherapy using drugs such as carboplatin, vincristine, and etoposide. Unfortunately, if conventional treatment fails, the affected eyes should be removed to prevent extension into adjacent tissues and metastasis. This study is to investigate the roles of L1 in adhesion-mediated proliferation and chemoresistance of retinoblastoma. L1 was differentially expressed in 30 retinoblastoma tissues and 2 retinoblastoma cell lines...
January 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28049286/is-islet-transplantation-a-realistic-approach-to-curing-diabetes
#9
REVIEW
Sang-Man Jin, Kwang-Won Kim
Since the report of type 1 diabetes reversal in seven consecutive patients by the Edmonton protocol in 2000, pancreatic islet transplantation has been reappraised based on accumulated clinical evidence. Although initially expected to therapeutically target long-term insulin independence, islet transplantation is now indicated for more specific clinical benefits. With the long-awaited report of the first phase 3 clinical trial in 2016, allogeneic islet transplantation is now transitioning from an experimental to a proven therapy for type 1 diabetes with problematic hypoglycemia...
January 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28045958/topical-recombinant-human-epidermal-growth-factor-for-oral-mucositis-induced-by-intensive-chemotherapy-with-hematopoietic-stem-cell-transplantation-final-analysis-of-a-randomized-double-blind-placebo-controlled-phase-2-trial
#10
Ji-Won Kim, Myeong Gyu Kim, Hyun Jung Lee, Youngil Koh, Ji-Hyun Kwon, Inho Kim, Seonyang Park, Byoung Kook Kim, Jung Mi Oh, Kyung Im Kim, Sung-Soo Yoon
The aim of this study was to evaluate the efficacy and safety of recombinant human epidermal growth factor (rhEGF) oral spray for oral mucositis (OM) induced by intensive chemotherapy with hematopoietic stem cell transplantation. In this phase 2 study, patients were randomized to either rhEGF (50 microg/mL) or placebo in a 1:1 ratio. The primary endpoint was incidence of National Cancer Institute (NCI) grade ≥2 OM. A total of 138 patients were enrolled in this study. In the intention-to-treat analysis, rhEGF did not reduce the incidence of NCI grade ≥2 OM (p = 0...
2017: PloS One
https://www.readbyqxmd.com/read/28034657/failure-of-physiologic-transformation-of-spiral-arteries-endothelial-and-trophoblast-cell-activation-and-acute-atherosis-in-the-basal-plate-of-the-placenta
#11
Carlos A Labarrere, Hector L Dicarlo, Elaine Bammerlin, James W Hardin, Yeon M Kim, Piya Chaemsaithong, David M Haas, Ghassan S Kassab, Roberto Romero
BACKGROUND: Failure of physiologic transformation of spiral arteries has been reported in preeclampsia, fetal growth restriction, fetal death, and spontaneous preterm labor with intact or ruptured membranes. Spiral arteries with failure of physiologic transformation are prone to develop atherosclerotic-like lesions of atherosis. There are striking parallels between preeclampsia and atherosclerotic disease, and between lesions of atherosis and atherosclerosis. Endothelial activation, identified by intercellular adhesion molecule-1 (ICAM-1) expression, is present in atherosclerotic-like lesions of heart transplantation, and is considered a manifestation of rejection...
December 26, 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28034338/bioengineering-strategies-to-treat-female-infertility
#12
Che-Ying Kuo, Hannah B Baker, Melissa H Fries, James J Yoo, Peter Cw Kim, John P Fisher
Bioengineering strategies have demonstrated enormous potential to treat female infertility as a result of chemotherapy, uterine injuries, fallopian tube occlusion, massive intrauterine adhesions, congenital uterine malformations and hysterectomy. These strategies can be classified into two broad categories: 1) Transplantation of fresh or cryopreserved organs into the host; and 2) tissue engineering approaches that utilize a combination of cells, growth factors and biomaterials that leverages the body's inherent ability to regenerate/repair reproductive organs...
December 30, 2016: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/28031549/clinicopathological-features-and-prognosis-of-hepatic-epithelioid-hemangioendothelioma-after-liver-resection-and-transplantation
#13
Dong-Hwan Jung, Shin Hwang, Seung-Mo Hong, Ki-Hun Kim, Young-Joo Lee, Chul-Soo Ahn, Deok-Bog Moon, Tae-Yong Ha, Gi-Won Song, Gil-Chun Park, Eunsil Yu, Sung-Gyu Lee
BACKGROUND Epithelioid hemangioendothelioma (EHE) is a rare vascular tumor. We present a single-center study on hepatic EHE cases treated by hepatic resection (HR) or liver transplantation (LT). MATERIAL AND METHODS Six HR patients with hepatic EHE were identified during 5 years from 2010 to 2014; EHE represented 0.13% (6 of 4572) of all primary liver tumors. Two LT recipients were also identified during 12 years from 2003 to 2014, who represented 0.06% (2 of 3576) of all adult LT patients. RESULTS Mean age of the patients was 42...
December 29, 2016: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/28031407/metabolic-acidosis-and-long-term-clinical-outcomes-in-kidney-transplant-recipients
#14
Seokwoo Park, Eunjeong Kang, Sehoon Park, Yong Chul Kim, Seung Seok Han, Jongwon Ha, Dong Ki Kim, Sejoong Kim, Su-Kil Park, Duck Jong Han, Chun Soo Lim, Yon Su Kim, Jung Pyo Lee, Young Hoon Kim
Metabolic acidosis (MA), indicated by low serum total CO2 (TCO2) concentration, is a risk factor for mortality and progressive renal dysfunction in CKD. However, the long-term effects of MA on kidney transplant recipients (KTRs) are unclear. We conducted a multicenter retrospective cohort study of 2318 adult KTRs, from January 1, 1997 to March 31, 2015, to evaluate the prevalence of MA and the relationships between TCO2 concentration and clinical outcomes. The prevalence of low TCO2 concentration (<22 mmol/L) began to increase in KTRs with eGFR<60 ml/min per 1...
December 28, 2016: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28030562/heterogeneous-niche-activity-of-ex-vivo-expanded-mscs-as-factor-for-variable-outcomes-in-hematopoietic-recovery
#15
Jung-Ho Kim, Ho-Sun Lee, Hyun-Kyung Choi, Jin-A Kim, In-Sun Chu, Sun-Hee Leem, Il-Hoan Oh
Ex-vivo expanded mesenchymal stromal cells (MSCs) are increasingly used for paracrine support of hematopoietic stem cell (HSC) regeneration, but inconsistent outcomes have hindered ongoing clinical trials. Here, we show that significant heterogeneity in the niche activity of MSCs is created during their culture in various serum-supplemented media. The MSCs cultured under stimulatory or non-stimulatory culture conditions exhibited differences in colony forming unit-fibroblast contents, expression levels of cross-talk molecules (Jagged-1 and CXCL-12) and their support for HSC self-renewal...
2016: PloS One
https://www.readbyqxmd.com/read/28029610/impact-of-local-injection-of-brain-derived-neurotrophic-factor-expressing-mesenchymal-stromal-cells-mscs-combined-with-intravenous-msc-delivery-in-a-canine-model-of-chronic-spinal-cord-injury
#16
Seung Hoon Lee, Yongsun Kim, Daeun Rhew, Ahyoung Kim, Kwang Rae Jo, Yongseok Yoon, Kyeung Uk Choi, Taeseong Jung, Wan Hee Kim, Oh-Kyeong Kweon
BACKGROUND AIMS: The microenvironment of the chronically injured spinal cord does not allow for axonal regeneration due to glial scarring. To ameliorate this, several therapeutic strategies have been used. We investigated whether combined transplantation of chondroitinase ABC (chABC) and mesenchymal stromal cells (MSCs) genetically modified to secrete brain-derived neurotrophic factor (BDNF) with intravenous (IV) administration of MSCs can promote recovery of hindlimb function after chronic spinal cord injury (SCI)...
October 28, 2016: Cytotherapy
https://www.readbyqxmd.com/read/28029326/ofatumumab-versus-rituximab-salvage-chemoimmunotherapy-in-relapsed-or-refractory-diffuse-large-b-cell-lymphoma-the-orcharrd-study
#17
Gustaaf W van Imhoff, Andrew McMillan, Matthew J Matasar, John Radford, Kirit M Ardeshna, Kazimierz Kuliczkowski, WonSeog Kim, Xiaonan Hong, Jette Soenderskov Goerloev, Andrew Davies, María Dolores Caballero Barrigón, Michinori Ogura, Sirpa Leppä, Michael Fennessy, Qiming Liao, Bronno van der Holt, Steen Lisby, Anton Hagenbeek
Purpose We compared the efficacy of ofatumumab (O) versus rituximab (R) in combination with cisplatin, cytarabine, and dexamethasone (DHAP) salvage treatment, followed by autologous stem-cell transplantation (ASCT) in patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL). Patients and Methods Patients with CD20(+) DLBCL age ≥ 18 years who had experienced their first relapse or who were refractory to first-line R-CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone)-like treatment were randomly assigned between three cycles of R-DHAP or O-DHAP...
December 28, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28028997/comparative-analysis-of-clinical-samples-showing-weak-serum-reaction-on-autovue-system-causing-abo-blood-typing-discrepancies
#18
Su Yeon Jo, Ju Mi Lee, Hye Lim Kim, Kyeong Hwa Sin, Hyeon Ji Lee, Chulhun Ludgerus Chang, Hyung Hoi Kim
BACKGROUND: ABO blood typing in pre-transfusion testing is a major component of the high workload in blood banks that therefore requires automation. We often experienced discrepant results from an automated system, especially weak serum reactions. We evaluated the discrepant results by the reference manual method to confirm ABO blood typing. METHODS: In total, 13,113 blood samples were tested with the AutoVue system; all samples were run in parallel with the reference manual method according to the laboratory protocol...
March 2017: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/28027599/long-term-prognosis-of-combined-hepatocellular-carcinoma-cholangiocarcinoma-following-liver-transplantation-and-resection
#19
Dong-Hwan Jung, Shin Hwang, Gi-Won Song, Chul-Soo Ahn, Deok-Bog Moon, Ki-Hun Kim, Tae-Yong Ha, Gil-Chun Park, Seung-Mo Hong, Wan-Jun Kim, Woo-Hyoung Kang, Seok- Hwan Kim, Eun Sil Yu, Sung-Gyu Lee
Combined hepatocellular carcinoma and cholangiocarcinoma (cHCC-CC) is a rare disease. We investigated the clinicopathological features of cHCC-CC and compared the long-term outcomes following liver transplantation (LT) and hepatic resection (HR). We identified 32 LT patients with cHCC-CC through an institutional database search. HR control group (n=100) was selected through propensity score-matching. The incidence of cHCC-CC among all adult LT cases was 1.0%. Mean patient age was 53.4±6.7 years and 26 patients were male...
December 27, 2016: Liver Transplantation
https://www.readbyqxmd.com/read/28018760/early-results-of-pilot-study-using-hepatitis-c-virus-hcv-positive-kidneys-to-transplant-hcv-infected-patients-with-end-stage-renal-disease-allowing-for-successful-interferon-free-direct-acting-antiviral-therapy-after-transplantation
#20
Juan F Gallegos-Orozco, Robin Kim, Heather F Thiesset, Jenny Hatch, Keisa Lynch, Thomas Chaly, Fuad Shihab, Faris Ahmed, Isaac Hall, Jeffrey Campsen
INTRODUCTION: Hepatitis C virus (HCV) infection in kidney transplant (KTX) patients reduces long-term patient and graft survival. Direct-acting antivirals (DAA) are > 90% effective in achieving sustained viral response (SVR); however, DAAs are not routinely available to patients with end-stage renal disease (ESRD). The University of Utah Transplant Program developed a protocol to allow HCV-positive potential KTX recipients to accept HCV-positive donors' kidneys. Three months after successful KTX, they were eligible for DAA therapy...
November 22, 2016: Curēus
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