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https://www.readbyqxmd.com/read/29452208/outcome-of-abo-incompatible-adult-living-donor-liver-transplantation-for-patients-with-hepatocellular-carcinoma
#1
Young-In Yoon, Gi-Won Song, Sung-Gyu Lee, Shin Hwang, Ki-Hun Kim, Seok-Hwan Kim, Woo-Hyoung Kang, Hwui-Dong Cho, Eun-Kyoung Jwa, Jae-Hyun Kwon, Eun-Young Tak, Varvara A Kirchner
BACKGROUND & AIMS: Living-donor liver transplantation (LDLT) can simultaneously cure hepatocellular carcinoma (HCC) and underlying liver cirrhosis, improving long-term results in patients with HCC. ABO-incompatible LDLT could expand the living-donor pool, reduce waiting times for deceased-donor liver transplantation, and improve long-term survival for some patients with HCC. METHODS: We retrospectively reviewed the medical records of patients undergoing LDLT for HCC from November 2008 to December 2015 at a single institution in Korea...
February 13, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29448134/enhancing-proliferation-and-optimizing-the-culture-condition-for-human-bone-marrow-stromal-cells-using-hypoxia-and-fibroblast-growth-factor-2
#2
Jung-Seok Lee, Seul Ki Kim, Byung-Joo Jung, Seong-Bok Choi, Eun-Young Choi, Chang-Sung Kim
This study aimed to determine the cellular characteristics and behaviors of human bone marrow stromal cells (hBMSCs) expanded in media in a hypoxic or normoxic condition and with or without fibroblast growth factor-2 (FGF-2) treatment. hBMSCs isolated from the vertebral body and expanded in these four groups were evaluated for cellular proliferation/migration, colony-forming units, cell-surface characterization, in vitro differentiation, in vivo transplantation, and gene expression. Culturing hBMSCs using a particular environmental factor (hypoxia) and with the addition of FGF-2 increased the cellular proliferation rate while enhancing the regenerative potential, modulated the multipotency-related processes (enhanced chondrogenesis-related processes/osteogenesis, but reduced adipogenesis), and increased cellular migration and collagen formation...
January 9, 2018: Stem Cell Research
https://www.readbyqxmd.com/read/29443826/higher-risk-of-posttransplant-graft-failure-in-male-recipients-of-female-donor-grafts-might-not-be-due-to-anastomotic-size-disparity
#3
Kyo Won Lee, Sangbin Han, Sanghoon Lee, Hyun-Hwa Cha, Soohyun Ahn, Hyeon Seon Ahn, Justin S Ko, Mi Sook Gwak, Gaab Soo Kim, Jae-Won Joh, Suk-Koo Lee, Gyu-Seong Choi
BACKGROUND: Posttransplant liver graft failure occurs most often in male recipients of livers from female donors. The respective role of donor sex itself and the size disparity in graft vessels/bile ducts according to donor sex are unclear. Thus, we aimed to evaluate the importance of donor sex with adjustment for anastomotic size disparity between female and male donor grafts. METHODS: A total of 309 male patients without hepatic tumors who underwent living donor liver transplantation were analyzed (109 female and 200 male donors)...
February 13, 2018: Transplantation
https://www.readbyqxmd.com/read/29442216/psychiatric-comorbidities-among-patients-undergoing-liver-transplantation-in-south-korea-a-nationwide-population-based-study
#4
Jaesung Heo, O Kyu Noh, Young-Taek Oh, Mison Chun, Logyoung Kim
OBJECTIVES: The aim of this study was to analyze the prevalence of mental disorders in patients undergoing liver transplantation (LT) based on claims data from the Health Insurance Review and Assessment Service (HIRA) in South Korea. METHODS: We confirmed mental disorders in a nationwide cohort of 3758 patients receiving LT between January 2010 and December 2014. We categorized the prevalence of mental disorders based on patient age at the time of LT. RESULTS: A total of 288 patients for LT were diagnosed with a mental disorder 1 year before their cancer diagnosis...
February 13, 2018: Hepatology International
https://www.readbyqxmd.com/read/29435902/pediatric-living-donor-liver-transplantation-using-a-monosegment-procured-by-pure-3d-laparoscopic-left-lateral-sectionectomy-and-in-situ-reduction
#5
Suk Kyun Hong, Kyung-Suk Suh, Hyo-Sin Kim, Kyung Chul Yoon, Sung-Woo Ahn, Hyeyoung Kim, Nam-Joon Yi, Kwang-Woong Lee
BACKGROUND: Improvements in laparoscopic imaging systems and instruments have increased the performance of pure laparoscopic living donor hepatectomy. This operation is no longer limited to left lateral sectionectomy but is used for left hepatectomy and right hepatectomy.1-5 This report describes a donor who underwent pure laparoscopic left lateral sectionectomy and in situ reduction using 3D laparoscopy and indocyanine green (ICG) near-infrared fluorescence cholangiography to obtain a monosegment...
February 12, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29434184/cyclosporin-a-aggravates-calcification-of-vascular-smooth-muscle-cells-under-high-glucose-conditions-with-a-calcifying-medium
#6
Dae Hee Kim, Keon Cheol Lee, Sang Youb Han
BACKGROUND Vascular calcification (VC) progresses substantially even after kidney transplantation, and is a predictor of morbidity and mortality. However, the effect of cyclosporin A (CsA) on VC has not been reported in diabetic kidney transplant patients. In this study, we evaluated the effect of CsA on the VC of mouse vascular smooth muscle cells (VSMCs) under high glucose (HG). MATERIAL AND METHODS To demonstrate the effect of CsA (1.0 µmol/L) and HG (30 mM) in the induction of the VC of the VSMCs, we determined alkaline phosphatase (ALP) activity, microscopic morphology of calcification, the expressions of the calcification and inflammation-related genes, and the intracellular calcium concentrations in VSMCs...
February 13, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/29431743/sorafenib-promotes-graft-versus-leukemia-activity-in-mice-and-humans-through-il-15-production-in-flt3-itd-mutant-leukemia-cells
#7
Nimitha R Mathew, Francis Baumgartner, Lukas Braun, David O'Sullivan, Simone Thomas, Miguel Waterhouse, Tony A Müller, Kathrin Hanke, Sanaz Taromi, Petya Apostolova, Anna L Illert, Wolfgang Melchinger, Sandra Duquesne, Annette Schmitt-Graeff, Lena Osswald, Kai-Li Yan, Arnim Weber, Sonia Tugues, Sabine Spath, Dietmar Pfeifer, Marie Follo, Rainer Claus, Michael Lübbert, Christoph Rummelt, Hartmut Bertz, Ralph Wäsch, Johanna Haag, Andrea Schmidts, Michael Schultheiss, Dominik Bettinger, Robert Thimme, Evelyn Ullrich, Yakup Tanriver, Giang Lam Vuong, Renate Arnold, Philipp Hemmati, Dominik Wolf, Markus Ditschkowski, Cordula Jilg, Konrad Wilhelm, Christian Leiber, Sabine Gerull, Jörg Halter, Claudia Lengerke, Thomas Pabst, Thomas Schroeder, Guido Kobbe, Wolf Rösler, Soroush Doostkam, Stephan Meckel, Kathleen Stabla, Stephan K Metzelder, Sebastian Halbach, Tilman Brummer, Zehan Hu, Joern Dengjel, Björn Hackanson, Christoph Schmid, Udo Holtick, Christof Scheid, Alexandros Spyridonidis, Friedrich Stölzel, Rainer Ordemann, Lutz P Müller, Flore Sicre-de-Fontbrune, Gabriele Ihorst, Jürgen Kuball, Jan E Ehlert, Daniel Feger, Eva-Maria Wagner, Jean-Yves Cahn, Jacqueline Schnell, Florian Kuchenbauer, Donald Bunjes, Ronjon Chakraverty, Simon Richardson, Saar Gill, Nicolaus Kröger, Francis Ayuk, Luca Vago, Fabio Ciceri, Antonia M Müller, Takeshi Kondo, Takanori Teshima, Susan Klaeger, Bernhard Kuster, Dennis Dong Hwan Kim, Daniel Weisdorf, Walter van der Velden, Daniela Dörfel, Wolfgang Bethge, Inken Hilgendorf, Andreas Hochhaus, Geoffroy Andrieux, Melanie Börries, Hauke Busch, John Magenau, Pavan Reddy, Myriam Labopin, Joseph H Antin, Andrea S Henden, Geoffrey R Hill, Glen A Kennedy, Merav Bar, Anita Sarma, Donal McLornan, Ghulam Mufti, Betul Oran, Katayoun Rezvani, Omid Sha, Robert S Negrin, Arnon Nagler, Marco Prinz, Andreas Burchert, Andreas Neubauer, Dietrich Beelen, Andreas Mackensen, Nikolas von Bubnoff, Wolfgang Herr, Burkhard Becher, Gerard Socié, Michael A Caligiuri, Eliana Ruggiero, Chiara Bonini, Georg Häcker, Justus Duyster, Jürgen Finke, Erika Pearce, Bruce R Blazar, Robert Zeiser
Individuals with acute myeloid leukemia (AML) harboring an internal tandem duplication (ITD) in the gene encoding Fms-related tyrosine kinase 3 (FLT3) who relapse after allogeneic hematopoietic cell transplantation (allo-HCT) have a 1-year survival rate below 20%. We observed that sorafenib, a multitargeted tyrosine kinase inhibitor, increased IL-15 production by FLT3-ITD+ leukemia cells. This synergized with the allogeneic CD8+ T cell response, leading to long-term survival in six mouse models of FLT3-ITD+ AML...
February 12, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29430938/visibility-of-the-graft-hepatic-artery-using-superb-microvascular-imaging-in-liver-transplantation-recipients-initial-experience
#8
Hye Young Jang, Kyoung Won Kim, So Yeon Kim, Jin Sil Kim, Sang Hyun Choi, Se-Young Kim, Sung-Gyu Lee
Background Hepatic artery (HA) obstruction is one of the most threatening complications following liver transplantation (LT); however, conventional color Doppler imaging (CDI) suffers from technical limitations regarding the visualization of fine vessels and low-velocity blood flow. Purpose To test the visibility of HA in postoperative evaluation of LT using a superb microvascular imaging (SMI). Material and Methods This retrospective study was approved by our institutional review board. Fifty-five consecutive patients (58 grafts; mean age = 56 years) who underwent LT with Doppler ultrasonography (US) on postoperative day 1 were included...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29430425/clinical-outcomes-of-lung-transplantation-experience-at-asan-medical-center
#9
Yong Ho Jeong, Sehoon Choi, Seung-Il Park, Dong Kwan Kim
Background: Lung transplantation is a life-saving procedure in patients with end-stage lung disease, and is increasingly performed in Korea. Methods: We retrospectively evaluated the outcomes of patients who received a lung transplant at Asan Medical Center between January 2008 and December 2016. Thirteen of 54 patients experienced multiorgan transplantation; the remaining 41 who received only lung grafts were included. Results: The mean age of the lung transplant recipients was 44...
February 2018: Korean Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29427734/increased-waitlist-mortality-and-lower-rate-for-liver-transplantation-in-hispanic-patients-with-primary-biliary-cholangitis
#10
George Cholankeril, Humberto C Gonzalez, Sanjaya Satapathy, Stevan A Gonzalez, Menghan Hu, Mohammad Ali Khan, Eric R Yoo, Andrew A Li, Donghee Kim, Satheesh Nair, Robert J Wong, Paul Y Kwo, Stephen A Harrison, Zobair M Younossi, Keith D Lindor, Aijaz Ahmed
BACKGROUND & AIMS: Data on the differences in ethnicity and race among patients with primary biliary cholangitis (PBC) awaiting liver transplantation (LT) are limited. We evaluated liver transplant waitlist trends and outcomes based on ethnicity and race in patients with PBC in the United States. METHODS: Using the United Network for Organ Sharing (UNOS) registry, we collected data on patients with PBC on the liver transplant waitlist, and performed analysis with a focus on ethnicity and race-based variations clinical manifestations, waitlist mortality and LT rates from 2000 to 2014...
February 7, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29427659/construction-of-emsc-islet-co-localizing-composites-for-xenogeneic-porcine-islet-transplantation
#11
Jung-Sik Kim, Hyunwoo Chung, Nari Byun, Seong-Jun Kang, Sunho Lee, Jun-Seop Shin, Chung-Gyu Park
Pancreatic islet transplantation is an ultimate solution for treating patients with type 1 diabetes (T1D). The pig is an ideal donor of islets for replacing scarce human islets. Besides immunological hurdles, non-immunological hurdles including fragmentation and delayed engraftment of porcine islets need solutions to succeed in porcine islet xenotransplantation. In this study, we suggest a simple but effective modality, a cell/islet co-localizing composite, to overcome these challenges. Endothelial-like mesenchymal stem cells (EMSCs), differentiated from bone-marrow derived mouse mesenchymal stem cells (MSCs), and MSCs evenly coated the surface of porcine islets (>85%) through optimized culture conditions...
February 7, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29427562/liver-paired-exchange-can-the-liver-emulate-the-kidney
#12
Ashish Mishra, Alexis Lo, Grace S Lee, Benjamin Samstein, Peter S Yoo, Matthew H Levine, David S Goldberg, Abraham Shaked, Kim M Olthoff, Peter L Abt
Kidney paired exchange (KPE) constitutes 12 percent of all living donor kidney transplants in the United States. 1 The success of KPE programs has prompted many in the liver transplant community to consider the possibility of liver paired exchange (LPE). Though the idea seems promising, the application has been limited to a handful of centers in Asia. 2,3 In this manuscript we consider the indications, logistical issues, and ethics for establishing a LPE program in the United States with reference to the principles and advances developed from experience with KPE...
February 10, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29423674/intravenous-infusion-of-human-adipose-tissue-derived-mesenchymal-stem-cells-to-treat-type-1-diabetic-mellitus-in-mice-an-evaluation-of-grafted-cell-doses
#13
Loan Thi-Tung Dang, Anh Nguyen-Tu Bui, Cong Le-Thanh Nguyen, Nhat Chau Truong, Anh Thi-Van Bui, Ngoc Phan Kim, Kiet Dinh Truong, Phuc Van Pham
Mesenchymal stem cell (MSC) transplantation is a novel treatment for diabetes mellitus, especially type 1 diabetes. Many recent publications have demonstrated the efficacy of MSC transplantation on reducing blood glucose and increasing insulin production in both preclinical and clinical trials. However, the investigation of grafted cell doses has been lacking. Therefore, this study aimed to evaluate the different doses of MSCs on treatment of type 1 diabetes in mouse models. MSCs were isolated and expanded from human adipose tissue...
February 9, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29410377/hepatobiliary-mri-as-novel-selection-criteria-in-liver-transplantation-for-hepatocellular-carcinoma
#14
Ah Yeong Kim, Dong Hyun Sinn, Woo Kyoung Jeong, Young Kon Kim, Tae Wook Kang, Sang Yun Ha, Chul Keun Park, Gyu Seong Choi, Jong Man Kim, Choon Hyuck David Kwon, Jae-Won Joh, Min-Ji Kim, Insuk Sohn, Sin-Ho Jung, Seung Woon Paik, Won Jae Lee
BACKGROUND AND AIMS: Hepatobiliary MRI provides additional information beyond size and number of the tumor, and may have prognostic implication. We tested whether pre-transplant radiologic features on MRI can stratify risk of tumor recurrence after liver transplantation (LT) for hepatocellular carcinoma (HCC). METHODS: A total of 100 liver transplanted patients who had preoperative gadoxetic acid-enhanced MRI, including the hepatobiliary phase (HBP), were reviewed for size, number, morphologic type (e...
February 2, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29408289/engaging-patients-in-setting-a-patient-centered-outcomes-research-agenda-in-hematopoietic-cell-transplantation
#15
Linda J Burns, Beatrice Abbetti, Stacie D Arnold, Jeffrey Bender, Susan Doughtie, Areej El-Jawahiri, Gloria Gee, Theresa Hahn, Mary M Horowitz, Shirley Johnson, Mark Juckett, Lakshmanan Krishnamurit, Susan Kullberg, C Fred LeMaistre, Alison Loren, Navneet S Majhail, Elizabeth A Murphy, Doug Rizzo, Alva Roche-Green, Wael Saber, Barry A Schatz, Kim Schmit-Pokorny, Bronwen E Shaw, Karen L Syrjala, D Kathryn Tierney, Christina Ullrich, David J Vanness, William A Wood, Ellen M Denzen
The goal of patient-centered outcomes research (PCOR) is to help patients and those who care for them make informed decisions about healthcare. However, the clinical research enterprise has not involved patients, caregivers, and other non-providers routinely in the process of prioritizing, designing and conducting research in hematopoietic cell transplantation (HCT). To address this need, the National Marrow Donor Program (NMDP)/Be The Match® engaged patients, caregivers, researchers and other key stakeholders in a two-year project with the goal of setting a PCOR agenda for the HCT community...
February 2, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29407897/species-specific-expression-of-phosphoglycerate-kinase-2-pgk2-in-the-developing-porcine-testis
#16
Hyun-Jung Park, Won-Young Lee, Chankyu Park, Kwon-Ho Hong, Jin-Hoi Kim, Hyuk Song
Whereas stage-specific markers for spermatogonial cells have been well investigated in mouse, the specific markers of germ cells in the testis of domestic animals have not been well defined. Phosphoglycerate kinase (PGK), an enzyme that converts 1,3-bisphosphoglycerate and adenosine diphosphate to 3-phosphoglycerate and adenosine triphosphate, has two isozymes: PGK1 and PGK2. In mouse, PGK1 exists only during the early stages of spermatogenesis, and PGK2 is then expressed during the pachytene spermatocyte stage...
February 1, 2018: Theriogenology
https://www.readbyqxmd.com/read/29407309/clinical-implication-of-tests-for-prostate-specific-antigen-in-brain-dead-organ-donors
#17
G W Lee, J-M Lee, W J Lee, Y B Kim, Y G Min
BACKGROUND: Although cancer screening tests are not mentioned under brain-dead organ donor care guidelines in Korea, we assessed the level of prostate-specific antigen (PSA), an important prostate cancer marker, and performed prostate biopsies when needed in brain-dead organ donors. We believe that insisting on a screening test for cancer diagnosis in donors' organs is important. MATERIALS AND METHODS: Data were collected between January 2010 and July 2015 from Ajou University Hospital...
January 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29406624/delivery-of-adipose-derived-stem-cells-in-poloxamer-hydrogel-improves-peripheral-nerve-regeneration
#18
Kassandra O Allbright, Jacqueline M Bliley, Emmanuelle Havis, Deok-Yeol Kim, Gabriella A Dibernardo, Damian Grybowski, Matthias Waldner, Isaac B James, Wesley N Sivak, J Peter Rubin, Kacey G Marra
INTRODUCTION: Peripheral nerve damage is associated with high long-term morbidity. Due to beneficial secretome, immunomodulatory effects, and ease of clinical translation, transplantation with adipose-derived stem cells (ASCs) represents a promising therapeutic modality. METHODS: Effect of ASC delivery within poloxamer hydrogel was assessed in a rat sciatic nerve model of critical-sized (1.5cm) peripheral nerve injury. Nerve/muscle unit regeneration was assessed via immunostaining explanted nerve and quantitative PCR (qPCR) and histological analysis of re-innervating gastrocnemius muscle...
February 6, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/29403022/satisfaction-with-sexual-activity-and-sexual-dysfunction-in-hematopoietic-stem-cell-transplantation-survivors-and-their-partners-a-couple-study
#19
Kwai Han Yoo, Danbee Kang, Im-Ryung Kim, Eun-Kyung Choi, Jin Seok Kim, Sung-Soo Yoon, Chul Hwan Lee, Silvia Park, Seok Jin Kim, Kihyun Kim, Won Seog Kim, Chul Won Jung, Hye Jin Choi, Jun Ho Jang, Juhee Cho
Sexual dysfunction is a common long-term complication of hematopoietic stem cell transplantation (HSCT). We assessed the extent to which HSCT survivors and their partners agree on the importance of and satisfaction with sexual activity and causes of sexual dysfunction, using a cross-sectional survey. Ratings of the importance of sexual activity were significantly higher in survivors than those of partners (2.57 vs. 2.14, P < 0.01). More survivors (48.4%) tried to discuss about sexuality with their partners than partners themselves (23...
February 5, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29399205/a-lasso-method-to-identify-protein-signature-predicting-post-transplant-renal-graft-survival
#20
Ling Zhou, Lu Tang, Angela T Song, Diane M Cibrik, Peter X-K Song
Identifying novel biomarkers to predict renal graft survival is important in post-transplant clinical practice. Serum creatinine, currently the most popular surrogate biomarker, offers limited information of the underlying allograft profiles. It is known to perform unsatisfactorily to predict renal function. In this paper, we apply a LASSO machine-learning algorithm in the Cox proportional hazards model to identify promising proteins that are associated with the hazard of allograft loss after renal transplantation, motivated by a clinical pilot study that collected 47 patients receiving renal transplants at the University of Michigan Hospital...
December 2017: Statistics in Biosciences
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