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https://www.readbyqxmd.com/read/29923981/abrupt-hemodynamic-changes-accompanying-intrapleural-hyperthermic-chemotherapy-case-series
#1
Hyae-Jin Kim, Hyeon-Jeong Lee, Eunsoo Kim, Jihwan Yun
RATIONALE: Intrapleural hyperthermic chemotherapy (IPHC) is the preferred method to locally treat lung cancer with pleural seeding. Anesthetic management during IPHC is a very challenging task for the anesthesiologist because of the hemodynamic instability associated with the procedure; however, there is no report on anesthetic considerations during the IPHC procedure. PATIENT CONCERNS: Three patients who diagnosed lung cancer with pleural invasion scheduled for IPHC were reported in this case series...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29923253/comparison-of-survival-outcome-between-donor-types-or-stem-cell-sources-for-childhood-acute-myeloid-leukemia-after-allogenic-hematopoietic-stem-cell-transplantation-a-multicenter-retrospective-study-of-study-alliance-of-yeungnam-pediatric-hematology-oncology
#2
Ye Jee Shim, Jae Min Lee, Heung Sik Kim, Nani Jung, Young Tak Lim, Eu Jeen Yang, Jeong Ok Hah, Young-Ho Lee, Hee Won Chueh, Jae Young Lim, Eun Sil Park, Jeong A Park, Ji Kyoung Park, Sang Kyu Park
We compared transplant outcomes between donor types and stem cell sources for childhood acute myeloid leukemia (AML). The medical records of children with AML in the Yeungnam region of Korea from January 2000 to June 2017 were reviewed. In all, 76 children with AML (male-to-female ratio = 46:30) received allogenic hematopoietic stem cell transplantation (allo-HSCT). In total, 29 patients received HSCT from either a matched-related donor or a mismatched-related donor, 32 patients received an unrelated donor, and 15 patients received umbilical cord blood...
June 19, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29921412/superoxide-dismutase-3-protects-mesenchymal-stem-cells-through-enhanced-autophagy-and-regulation-of-foxo3a-trafficking
#3
Gaurav Agrahari, Shyam Kishor Sah, Tae-Yoon Kim
Therapeutic applications of mesenchymal stem cells (MSCs) are limited due to their early death within the first few days of transplantation. Therefore, to improve the efficacy of cell-based therapies, it is necessary to manipulate MSCs so that they can resist various stresses imposed by the microenvironment. Moreover, the role of superoxide dismutase 3 (SOD3) in regulating such survival under different stress conditions remain elusive. In this study, we overexpressed SOD3 in MSCs (SOD3-MSCs) and evaluated its effect under serum starvation conditions...
June 20, 2018: BMB Reports
https://www.readbyqxmd.com/read/29909686/improved-healing-after-the-co-transplantation-of-ho-1-and-bdnf-overexpressed-mesenchymal-stem-cells-in-the-subacute-spinal-cord-injury-of-dogs
#4
Imdad Ullah Khan, Yongseok Yoon, Ahyoung Kim, Kwang Rae Jo, Kyeung Uk Choi, Taeseong Jung, Namyul Kim, YeonSung Son, Wan Hee Kim, Oh-Kyeong Kweon
Abundant expression of proinflammatory cytokines after a spinal cord injury (SCI) creates an inhibitory microenvironment for neuroregeneration. The mesenchymal stem cells help to mitigate the inflammation and improve neural growth and survival. For this purpose, we potentiated the function of adipose-derived mesenchymal stem cells (Ad-MSCs) by transfecting them with brain-derived neurotrophic factor (BDNF) and heme oxygenase-1 (HO-1), through a lentivirus, to produce BDNF overexpressed Ad-MSCs (BDNF-MSCs), and HO-1 overexpressed Ad-MSCs (HO-1-MSCs)...
January 1, 2018: Cell Transplantation
https://www.readbyqxmd.com/read/29908011/pretransplant-increases-in-left-ventricular-volume-and-mass-are-associated-with-qt-prolongation-during-pediatric-liver-transplantation
#5
Hyun-Seok Cho, Wook-Jong Kim, Byungdoo Andrew Lee, Junki Cho, Won-Jung Shin, Gyu-Sam Hwang
Structural alterations in the cirrhotic heart may contribute to electromechanical abnormalities, represented by QT prolongation. The aim of this study was to investigate the changes in QTc according to the operative stage during pediatric LT and to identify which baseline echocardiographic parameters were associated with intraoperative QTc prolongation. Data were evaluated from 39 children undergoing LT for chronic liver disease (median age 9 months). In 19 patients (48.7%), baseline QTc was prolonged ≥440 ms (462 ± 19 ms)...
June 15, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29907500/inhibition-of-regulated-necrosis-attenuates-receptor-interacting-protein-kinase-1-mediated-ischemia-reperfusion-injury-after-lung-transplantation
#6
Takashi Kanou, Akihiro Ohsumi, Hyunhee Kim, Manyin Chen, Xiaohui Bai, Zehong Guan, David Hwang, Marcelo Cypel, Shaf Keshavjee, Mingyao Liu
BACKGROUND: Increasing evidence indicates that regulated necrosis plays a critical role during cell death caused by ischemia-reperfusion (IR) injury. Necroptosis is one form of regulated necrosis. Necrostatin-1 (Nec-1), an inhibitor of receptor-interacting protein kinase 1 (RIPK1), is known to reduce necroptosis. We investigated the effect of Nec-1 treatment on IR-induced lung injury in a rat lung transplant model. METHODS: Lewis rats were divided into 4 groups (n = 6 each): (1) Control (no treatment), (2) Donor treatment (D), (3) Recipient treatment (R), and (4) Donor plus Recipient treatment (D+R) groups...
April 26, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29904040/a-pilot-trial-to-examine-the-changes-in-carotid-arterial-inflammation-in-renal-transplant-recipients-as-assessed-by-18f-fluorodeoxyglucose-18f-fdg-positron-emission-tomography-computed-tomography-pet-ct
#7
Hye Eun Yoon, Yaeni Kim, Sang Dong Kim, Jin Kyoung Oh, Yong-An Chung, Seok Joon Shin, Chul Woo Yang, Suk Min Seo
BACKGROUND Inflammatory activity of the artery can be assessed by measuring 18F-fluorodeoxyglucose (18F-FDG) uptake with positron emission tomography computed tomography (PET/CT). Improvement in vascular function after renal transplantation has been reported, but no studies have used 18F-FDG PET/CT to examine the changes in vascular inflammation. This study investigated the changes in the inflammatory activity in the carotid artery after renal transplantation in patients with chronic kidney disease (CKD). MATERIAL AND METHODS 18F-FDG PET/CT was performed before and at 4 months after transplantation...
June 15, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/29900002/hospitalizations-in-dialysis-patients-in-canada-a-national-cohort-study
#8
Amber O Molnar, Louise Moist, Scott Klarenbach, Jean-Philippe Lafrance, S Joseph Kim, Karthik Tennankore, Jeffrey Perl, Joanne Kappel, Michael Terner, Jagbir Gill, Manish M Sood
Background: Hospitalizations of chronic dialysis patients have not been previously studied at a national level in Canada. Understanding the scope and variables associated with hospitalizations will inform measures for improvement. Objective: To describe the risk of all-cause and infection-related hospitalizations in patients on dialysis. Design: Retrospective cohort study using health care administrative databases. Setting: Provinces and territories across Canada (excluding Manitoba and Quebec)...
2018: Canadian Journal of Kidney Health and Disease
https://www.readbyqxmd.com/read/29899998/a-longitudinal-study-examining-the-change-in-functional-independence-over-time-in-elderly-individuals-with-a-functioning-kidney-transplant
#9
Kevin Yau, Janine F Farragher, S Joseph Kim, Olusegun Famure, Sarbjit V Jassal
Background: Functional disability is defined as the need for assistance with self-care tasks. Objective: To document changes in functional status over time among older prevalent renal transplant recipients. Design: Single center, prospective, follow-up study. Setting: Single center, tertiary care transplant center. Patients: Patients, with a functioning kidney transplant, aged 65 years or older who underwent assessment of functional status approximately 12 months previously...
2018: Canadian Journal of Kidney Health and Disease
https://www.readbyqxmd.com/read/29898740/prognostic-value-of-myocardial-strain-and-late-gadolinium-enhancement-on-cardiovascular-magnetic-resonance-imaging-in-patients-with-idiopathic-dilated-cardiomyopathy-with-moderate-to-severely-reduced-ejection-fraction
#10
Seung-Hoon Pi, Sung Mok Kim, Jin-Oh Choi, Eun Kyoung Kim, Sung-A Chang, Yeon Hyeon Choe, Sang-Chol Lee, Eun-Seok Jeon
BACKGROUND: It has been reported that left ventricular (LV) myocardial strain and late gadolinium enhancement (LGE) on cardiovascular magnetic resonance (CMR) imaging have prognostic value in patients with heart failure (HF). However, previous studies included patients with various systolic functions. This study aimed to investigate the prognostic value of LV myocardial strain and LGE on CMR imaging in patients with idiopathic dilated cardiomyopathy (DCM) with reduced ejection fraction (EF < 40%)...
June 14, 2018: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29891834/reduced-tacrolimus-trough-level-is-reflected-by-estimated-glomerular-filtration-rate-egfr-changes-in-stable-renal-transplantation-recipients-results-of-the-optimum-phase-3-randomized-controlled-study
#11
Sehoon Park, Yon Su Kim, Jungpyo Lee, Wooseong Huh, Chul Woo Yang, Young-Lim Kim, Yeong Hoon Kim, Joong Kyung Kim, Chang-Kwon Oh, Su-Kil Park
BACKGROUND Minimizing the tacrolimus dosage in patients with stable allograft function needs further investigation. MATERIAL AND METHODS We performed an open-label, randomized, controlled study from 2010 to 2016 in 7 tertiary teaching hospitals in Korea and enrolled 345 kidney transplant recipients with a stable graft status. The study group received reduced-dose tacrolimus, 1080-1440 mg/day of enteric-coated mycophenolate sodium (EC-MPS), and corticosteroids. The control group received the standard tacrolimus dosage and 540-720 mg/day of EC-MPS with steroids...
June 12, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/29888545/long-term-outcomes-of-liver-transplantation-for-hepatoblastoma-a-single-center-14-year-experience
#12
Gabriel Ramos-Gonzalez, Michael LaQuaglia, Allison F O'Neill, Scott Elisofon, David Zurakowski, Heung Bae Kim, Khashayar Vakili
HB is the most common primary liver tumor in children. Complete tumor excision, either by partial resection or by total hepatectomy and liver transplantation, in combination with chemotherapy provides the best chance for cure. We performed a retrospective analysis of patients who underwent liver transplantation for HB and herein present our 14-year single-institution experience. Twenty-five patients underwent liver transplantation for HB at a median age of 26 months (IQR: 15-44). Graft survival was 96%, 87%, and 80% at 1, 3, and 5 years, respectively...
June 11, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29883808/polymeric-microsphere-facilitated-site-specific-delivery-of-quercetin-prevents-senescence-of-pancreatic-islets-in-vivo-and-improves-transplantation-outcomes-in-mouse-model-of-diabetes
#13
Shiva Pathak, Shobha Regmi, Tiep Tien Nguyen, Biki Gupta, Milan Gautam, Chul Soon Yong, Jong Oh Kim, Youlim Son, Jae-Ryong Kim, Min Hui Park, Young Kyung Bae, So Young Park, Daewon Jeong, Simmyung Yook, Jee-Heon Jeong
Attenuation of senescence progression may be attractive way to preserve the functionality of pancreatic islets (PI) after transplantation. In this study, we developed a model for in vitro induction of premature senescence in rat PI and showed the effectiveness of quercetin (QU) to prevent the senescence. To provide targeted-delivery of QU to the PI after transplantation, we prepared the hybrid clusters (HC) of islet single cells (ISC) and QU-loaded polymeric microspheres (QU; ∼7.55 ng HC-1 ). Long-term culture of the HC revealed reduced levels of reactive oxygen species and decreased expression of senescence-associated beta galactosidase, Rb, p53, p16, and p21 compared to that of the control islets...
June 5, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29880964/nash-leading-cause-of-liver-transplant-in-women-updated-analysis-of-indications-for-liver-transplant-and-ethnic-and-gender-variances
#14
Mazen Noureddin, Aarshi Vipani, Catherine Bresee, Tsuyoshi Todo, Irene K Kim, Naim Alkhouri, Veronica Wendy Setiawan, Tram Tran, Walid S Ayoub, Shelly C Lu, Andrew S Klein, Vinay Sundaram, Nicholas N Nissen
OBJECTIVES: Chronic infection with hepatitis C virus (HCV) was previously the leading indication for liver transplant (LT) in the United States. However, since 2014 the use of direct-acting antivirals (DAAs) has decreased the chronic HCV burden, while the prevalence of nonalcoholic steatohepatitis (NASH) has risen substantially through the last decade. Both gender and ethnic disparities in indications for LT have been shown in the past but no data on this have been reported since the implementation of DAAs...
June 8, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29879018/role-of-heterotopic-kidney-auto-transplantation-for-renal-artery-aneurysms
#15
Jun G Gwon, Duck J Han, Yong-Pil Cho, Young H Kim, Tae-Won Kwon
To assess the applicability and surgical outcomes of ex vivo repair with heterotopic kidney auto-transplantation (HKA) for the treatment of renal artery aneurysms (RAA).We retrospectively examined 36 cases presenting with RAA from September 2005 to June 2016. Patient demographics, estimated glomerular filtration rate (eGFR), and common vascular risk factors were evaluated. Patients were classified into 3 groups: those who received endovascular treatment, in situ open surgical repair, or ex vivo repair with HKA...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29877001/clinical-significance-of-isoagglutinin-titer-with-the-current-desensitization-protocol-in-abo-incompatible-kidney-transplantation
#16
Chung Hee Baek, Hyosang Kim, Won Seok Yang, Duck Jong Han, Su-Kil Park
AIM: ABO-incompatible (ABOi) kidney transplantation (KT) has become a routine procedure with graft survival rates comparable to those of ABO-compatible KT. However, the clinical significance of the isoagglutinin titer in ABOi KT remains uncertain. Therefore, in this study, we analyzed the clinical outcomes of ABOi KT according to the baseline and postoperative isoagglutinin titer. METHODS: All patients who received ABOi KT between 2009 and 2013 were reviewed and followed up until December 2016...
June 7, 2018: Nephrology
https://www.readbyqxmd.com/read/29871774/high-dose-intravenous-immunoglobulin-treatment-of-polyomavirus-nephropathy-developing-after-t-cell-mediated-rejection-treatment-a-case-report
#17
S D Hwang, J H Lee, S W Lee, J K Kim, M-J Kim, J H Song
BACKGROUND: Reactivation of BK polyomavirus causes destructive virus allograft nephropathy; however, treatment options are limited. Herein, we report a case in which a patient with T cell-mediated rejection was treated with steroid therapy. The patient subsequently developed BK viremia and was successfully treated by using intravenous immunoglobulin (IVIG) after failing to respond to conventional treatment. CASE PRESENTATION: A 54-year-old man had been undergoing peritoneal dialysis for 3 years before kidney transplantation...
June 2, 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29871764/five-year-mortality-hazard-is-reduced-in-chronic-obstructive-pulmonary-disease-patients-receiving-double-versus-single-lung-transplants
#18
Todd C Crawford, Cecillia Lui, J Trent Magruder, Jinny S Ha, Robert S Higgins, Christian A Merlo, Bo S Kim, Errol L Bush
BACKGROUND: Previous studies suggest double-lung transplant (DLT) may be associated with superior survival compared to single-lung transplantation (SLT) in chronic obstructive pulmonary disease (COPD) recipients. The purpose of this study was to compare survival in patients with COPD undergoing DLT versus SLT since the inception of the lung allocation score. METHODS: We used the United Network for Organ Sharing database to retrospectively identify adult patients with COPD who underwent isolated lung transplantation from 5/4/2005-12/31/2014...
June 2, 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29871515/dual-effects-of-human-placenta-derived-neural-cells-on-neuroprotection-and-the-inhibition-of-neuroinflammation-in-a-rodent-model-of-parkinson-s-disease
#19
Han Wool Kim, Hyun-Seob Lee, Jun Mo Kang, Sang-Hun Bae, Chul Kim, Sang-Hun Lee, Johannes Schwarz, Gi Jin Kim, Jin-Su Kim, Dong Hyun Cha, Joopyung Kim, Sung Woon Chang, Tae Hee Lee, Jisook Moon
Parkinson's disease (PD) is the second most common age-related neurodegenerative disease in the elderly and the patients suffer from uncontrolled movement disorders due to loss of dopaminergic (DA) neurons on substantia nigra pars compacta (SNpc). We previously reported that transplantation of human fetal midbrain-derived neural precursor cells restored the functional deficits of a 6-hydroxy dopamine (6-OHDA)-treated rodent model of PD but its low viability and ethical issues still remain to be solved. Albeit immune privilege and neural differentiation potentials suggest mesenchymal stem cells (MSCs) from various tissues including human placenta MSCs (hpMSCs) for an alternative source, our understanding of their therapeutic mechanisms is still limited...
January 1, 2018: Cell Transplantation
https://www.readbyqxmd.com/read/29869918/doppler-ultrasound-follow-up-of-middle-hepatic-vein-tributaries-interposition-vessel-graft-in-recipients-of-living-donor-liver-transplantation-using-modified-right-lobe-grafts
#20
Sunyoung Lee, Kyoung Won Kim, So Yeong Jeong, Kyung Jin Lee, So Yeon Kim, Gi Won Song, Sung Gyu Lee
OBJECTIVES: To investigate the value of Doppler ultrasound (US) in recipients of living donor liver transplantation (LDLT) using modified right-lobe grafts (mRLGs) with obstruction of the middle hepatic vein tributaries (MHVTs)-interposition vessel graft (IVG). METHODS: This study included 240 consecutive LDLT recipients in whom 564 MHVTs (>5 mm) were reconstructed using IVG. Regular follow-up Doppler US was performed to assess the patency of the MHVTs-IVG and, if there was an obstruction, to evaluate for the establishment of collateral drainage...
June 5, 2018: British Journal of Radiology
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