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https://www.readbyqxmd.com/read/29050459/third-party-regulatory-t-cells-prevent-murine-acute-graft-versus-host-disease
#1
Jung-Yeon Lim, Keon-Il Im, Yunejin Song, Nayoun Kim, Young-Sun Nam, Young-Woo Jeon, Seok-Goo Cho
Background/Aims: Adoptive therapy with regulatory T (Treg) cells to prevent graft-versus-host disease (GVHD) would benefit from a strategy to improve homing to the sites of inflammation following hematopoietic stem cell transplantation (HSCT). Although donor-derived Treg cells have mainly been used in these models, third-party-derived Treg cells are a promising alternative for cell-based immunotherapy, as they can be screened for pathogens and cell activity, and banked for GVHD prevention...
October 19, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29050351/the-prognostic-significance-of-preoperative-left-ventricular-diastolic-dysfunction-and-left-atrial-enlargement-on-acute-coronary-syndrome-in-kidney-transplantation
#2
Jin Ho Hwang, Jun-Bean Park, Yong-Jin Kim, Jung Nam An, Jaeseok Yang, Curie Ahn, In Mok Jung, Chun Soo Lim, Yon Su Kim, Young Hoon Kim, Jung Pyo Lee
Echocardiography is commonly performed as a screening test to evaluate perioperative risks before kidney transplantation. However, only limited data are available on echocardiographic parameters of left ventricular diastolic dysfunction (LVDD) and left atrial enlargement (LAE) on acute coronary syndrome and mortality in kidney transplant recipients. We reviewed 2779 adult recipients who underwent pretransplant echocardiography from 1997 to 2012. We divided the patients into two and four groups by two categories: LVDD grades 0-1 vs...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29045706/kidney-injury-molecule-1-staining-in-renal-allograft-biopsies-10-days-after-transplantation-is-inversely-correlated-with-functioning-proximal-tubular-epithelial-cells
#3
Jonna R Bank, Pieter van der Pol, Dianne Vreeken, Catherine Monge-Chaubo, Ingeborg M Bajema, Nicole Schlagwein, Daniëlle J van Gijlswijk, Sandra W van der Kooij, Marlies E J Reinders, Johan W de Fijter, Cees van Kooten
Background: Kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) are promising biomarkers for monitoring delayed graft function (DGF) after kidney transplantation. Here we investigated localization and distribution of KIM-1 and NGAL staining in renal allograft biopsies and studied their association with histological features, functional DGF (fDGF) and the tubular function slope (TFS), a functioning proximal tubular epithelial cell (PTEC) marker. Methods: Day 10 protocol biopsies of 64 donation after circulatory death recipients were stained for KIM-1 and NGAL and the positive area was quantified using ImageJ software...
October 16, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29044729/outcome-comparison-of-liver-transplantation-for-hepatitis-a-related-versus-hepatitis-b-related-acute-liver-failure-in-adult-recipients
#4
Dong-Hwan Jung, Shin Hwang, Young-Suk Lim, Ki-Hun Kim, Chul-Soo Ahn, Deok-Bog Moon, Tae-Yong Ha, Gi-Won Song, Gil-Chun Park, Sung-Gyu Lee
Hepatitis A virus (HAV) can cause acute liver failure (ALF). This study compares outcomes between liver transplantation (LT) for HAV-related ALF (HAV-ALF) and LT for Hepatitis B virus (HBV)-related ALF (HBV-ALF). Of 3,616 adult LTs performed between January 2005 and December 2014, we performed LT for HAV-ALF recipients (n = 29) and LT for HBV-ALF recipients (n = 34). HAV-ALF group included 18 males and 11 females with mean age of 33.1 years. Graft survival rates in HAV-ALF and HBV-ALF were 65.5% and 88.0% (1 year) and 65...
October 17, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/29040031/prospective-randomized-double-blind-phase-iii-clinical-trial-of-anti-t-lymphocyte-globulin-to-assess-impact-on-chronic-graft-versus-host-disease-free-survival-in-patients-undergoing-hla-matched-unrelated-myeloablative-hematopoietic-cell-transplantation
#5
Robert J Soiffer, Haesook T Kim, Joseph McGuirk, Mitchell E Horwitz, Laura Johnston, Mrinal M Patnaik, Witold Rybka, Andrew Artz, David L Porter, Thomas C Shea, Michael W Boyer, Richard T Maziarz, Paul J Shaughnessy, Usama Gergis, Hana Safah, Ran Reshef, John F DiPersio, Patrick J Stiff, Madhuri Vusirikala, Jeff Szer, Jennifer Holter, James D Levine, Paul J Martin, Joseph A Pidala, Ian D Lewis, Vincent T Ho, Edwin P Alyea, Jerome Ritz, Frank Glavin, Peter Westervelt, Madan H Jagasia, Yi-Bin Chen
Purpose Several open-label randomized studies have suggested that in vivo T-cell depletion with anti-T-lymphocyte globulin (ATLG; formerly antithymocyte globulin-Fresenius) reduces chronic graft-versus-host disease (cGVHD) without compromising survival. We report a prospective, double-blind phase III trial to investigate the effect of ATLG (Neovii Biotech, Lexington, MA) on cGVHD-free survival. Patients and Methods Two hundred fifty-four patients 18 to 65 years of age with acute leukemia or myelodysplastic syndrome who underwent myeloablative HLA-matched unrelated hematopoietic cell transplantation (HCT) were randomly assigned one to one to placebo (n =128 placebo) or ATLG (n = 126) treatment at 27 sites...
October 17, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29037890/double-expressor-lymphoma-is-associated-with-poor-outcomes-after-allogeneic-hematopoietic-cell-transplantation
#6
Ichiro Kawashima, Yoshihiro Inamoto, Akiko Miyagi Maeshima, Junko Nomoto, Kinuko Tajima, Tadahiro Honda, Takafumi Shichijo, Akihisa Kawajiri, Tomonari Takemura, Akio Onishi, Ayumu Ito, Takashi Tanaka, Shigeo Fuji, Saiko Kurosawa, Sung-Won Kim, Dai Maruyama, Kensei Tobinai, Yukio Kobayashi, Takahiro Fukuda
Double-expressor lymphoma is a diffuse large B-cell lymphoma that exhibits co-expression of MYC and BCL2 proteins by immunohistochemistry. Patients with double-expressor lymphoma have a poor prognosis after standard chemoimmunotherapy or after high-dose chemotherapy with autologous transplantation, but the prognostic impact of double-expressor lymphoma after allogeneic hematopoietic cell transplantation has not been well determined. We retrospectively analyzed 60 consecutive patients with de novo diffuse large B-cell lymphoma or transformed follicular lymphoma who underwent allogeneic transplantation at our center and whose immunohistochemistry results were available...
October 13, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29037020/factors-associated-with-pulmonary-toxicity-after-myeloablative-conditioning-using-fractionated-total-body-irradiation
#7
Hwa Kyung Byun, Hong In Yoon, Jaeho Cho, Hyun Ju Kim, Yoo Hong Min, Chuhl Joo Lyu, June-Won Cheong, Jin Seok Kim, Hyo Sun Kim, Soo-Jeong Kim, Andrew Jihoon Yang, Byung Min Lee, Won Hee Lee, Joongyo Lee, Ki Jung Ahn, Chang-Ok Suh
PURPOSE: Pulmonary toxicities, including infectious pneumonia (IP) and idiopathic pneumonia syndrome (IPS), are serious side effects of total body irradiation (TBI) used for myeloablative conditioning. This study aimed to evaluate clinical factors associated with IP and IPS following TBI. MATERIALS AND METHODS: Fifty-eight patients with hematologic malignancies who underwent TBI before allogeneic hematopoietic stem cell transplantation between 2005 and 2014 were reviewed...
September 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/29035428/initial-report-of-the-korean-organ-transplant-registry-kotry-heart-transplantation
#8
Hae Young Lee, Eun Seok Jeon, Seok Min Kang, Jae Joong Kim
BACKGROUND AND OBJECTIVES: The Korean Organ Transplant Registry (KOTRY), which was the first national transplant registry in Korea, was founded by the Korean Society for Transplantation and the Korean Center for Disease Control in 2014. Here, we present the initial report of the Korean Heart Transplant Registry. METHODS: A total of 183 heart transplantation (HTPL) patients performed at 4 nationally representative hospitals were collected from April 2014 to December 2015...
August 16, 2017: Korean Circulation Journal
https://www.readbyqxmd.com/read/29033547/new-tablet-formulation-of-tacrolimus-with-smaller-interindividual-variability-may-become-a-better-treatment-option-than-the-conventional-capsule-formulation-in-organ-transplant-patients
#9
Yu Kyong Kim, Anhye Kim, Shin Jung Park, Howard Lee
To evaluate the pharmacokinetic (PK) and tolerability profiles of a new tablet formulation of tacrolimus and its interindividual variability (IIV) in the systemic exposure, and to compare them with those of the conventional capsule formulation, a randomized, open-label, two-treatment, two-period, two-sequence, crossover study was performed in 47 healthy males. The capsule or tablet formulation of tacrolimus was orally administered, and serial blood samples were collected up to 96 hours after dosing. Whole-blood tacrolimus concentration was determined using liquid chromatography-tandem mass spectrometry...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29033224/downstaging-therapy-followed-by-liver-transplantation-for-hepatocellular-carcinoma-beyond-milan-criteria
#10
Young Kim, Christopher C Stahl, Abouelmagd Makramalla, Olugbenga O Olowokure, Ross L Ristagno, Vikrom K Dhar, Michael R Schoech, Seetharam Chadalavada, Tahir Latif, Jordan Kharofa, Khurram Bari, Shimul A Shah
BACKGROUND: Orthotopic liver transplantation is a curative treatment for hepatocellular carcinoma within Milan criteria, but these criteria preclude many patients from transplant candidacy. Recent studies have demonstrated that downstaging therapy can reduce tumor burden to meet conventional criteria. The present study reports a single-center experience with tumor downstaging and its effects on post-orthotopic liver transplantation outcomes. METHODS: All patients with hepatocellular carcinoma who were evaluated by our multidisciplinary liver services team from 2012 to 2016 were identified (N = 214)...
October 12, 2017: Surgery
https://www.readbyqxmd.com/read/29027353/early-predictors-of-mortality-in-children-with-pulmonary-complications-after-haematopoietic-stem-cell-transplantation
#11
Yu Hyeon Choi, Hyung Joo Jeong, Hong Yul An, You Sun Kim, Eui Jun Lee, Bongjin Lee, Hyoung Jin Kang, Hee Young Shin, June Dong Park
PC are a main cause of death following HSCT in children. We aimed to evaluate early predictors of mortality in paediatric recipients with PCs. A retrospective observational study of 35 patients with 49 episodes of PI on chest radiography (of 124 patients) who had undergone HSCT at a tertiary university hospital between January 2011 and December 2012 was performed. During follow-up (median 26.1 months), 15 episodes led to death (30.6%). An aetiologic diagnosis was made by non-invasive tests in 24 episodes (49...
October 12, 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/29026966/the-clinical-implications-of-liver-resection-margin-size-in-patients-with-hepatocellular-carcinoma-in-terms-of-positron-emission-tomography-positivity
#12
Jae Hyun Park, Dong Hwi Kim, Sung Hoon Kim, Moon Young Kim, Soon Koo Baik, In Su Hong
BACKGROUND: The positivity of positron emission tomography (PET) in hepatocellular carcinoma (HCC) correlates with aggressive tumor factors and poor survival. Adequate resection margin size is still a topic of debate. We analyzed the clinical implications of resection margin size in patients with HCC in terms of PET positivity. METHODS: We retrospectively reviewed the medical records of 92 patients who underwent liver resection from March 2012 to October 2015. We investigated prognostic factors for recurrence and survival...
October 12, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29024935/venous-thromboembolism-and-the-risk-of-death-and-graft-loss-in-kidney-transplant-recipients
#13
Ngan N Lam, Amit X Garg, Greg A Knoll, S Joseph Kim, Krista L Lentine, Eric McArthur, Kyla L Naylor, Sarah E Bota, Manish M Sood
BACKGROUND: The implications of venous thromboembolism (VTE) for morbidity and mortality in kidney transplant recipients are not well described. METHODS: We conducted a retrospective study using linked healthcare databases in Ontario, Canada to determine the risk and complications of VTE in kidney transplant recipients from 2003 to 2013. We compared the incidence rate of VTE in recipients (n = 4,343) and a matched (1:4) sample of the general population (n = 17,372)...
October 12, 2017: American Journal of Nephrology
https://www.readbyqxmd.com/read/29024412/risk-of-post-transplant-hepatocellular-carcinoma-recurrence-is-greater-in-recipients-with-higher-platelet-counts-in-living-donor-liver-transplantation
#14
Sangbin Han, Sanghoon Lee, Ju Dong Yang, Michael Douglas Leise, Joong Hyun Ahn, Seonwoo Kim, Gangha Jung, Mi Sook Gwak, Gaab Soo Kim, Justin Sangwook Ko
Platelets interact with tumor cells and promote metastasis. The importance of platelets in post-transplant hepatocellular carcinoma (HCC) recurrence is unclear. Thus, we aimed to evaluate the association between preoperative platelet count and HCC recurrence after living donor liver transplantation. Of 359 recipients of livers from living donors for HCC, 209 of 240 patients who had preoperative platelet count ≤75 × 10(9) /L were matched with 97 of 119 patients who had preoperative platelet count >75 × 10(9) /L using propensity score matching, with an unfixed matching ratio based on factors such as tumor biology...
October 11, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/29024353/exercise-and-physical-activity-for-patients-with-esld-improving-functional-status-and-sarcopenia-while-on-the-transplant-waitlist
#15
REVIEW
Andrés Duarte-Rojo, Astrid Ruiz-Margáin, Aldo J Montaño-Loza, Ricardo Macías-Rodríguez, Arny Ferrando, W Ray Kim
Sarcopenia and physical deconditioning are frequent complications in patients with cirrhosis and end-stage liver disease (ESLD). They are the end result of impaired dietary intake, chronic inflammation, altered macro- and micronutrient metabolism, and low physical activity. Frailty is the end result of prolonged sarcopenia and physical deconditioning. It severely affects a patient's functional status, and presents in about 1 in 5 patients on the liver transplant (LT) waitlist. Sarcopenia, poor physical fitness/cardiopulmonary endurance, and frailty are all associated with increased mortality in ESLD...
October 11, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28990128/a-single-center-retrospective-analysis-to-compare-the-efficacy-and-safety-of-filgrastim-sndz-to-filgrastim-for-prophylaxis-of-chemotherapy-induced-neutropenia-and-for-neutrophil-recovery-following-autologous-stem-cell-transplantation
#16
Julia Zecchini, Kendra Yum, Amir Steinberg, Cardinale Smith, Sara Kim
Filgrastim-sndz (Zarxio®) was approved by the FDA in March 2015 as a biosimilar product of its reference product, filgrastim (Neupogen®) for all five indications. The NCCN Clinical Practice Guidelines has incorporated filgrastim-sndz into its recommendations as a category 1 recommendation for use in settings of febrile neutropenia, myelosuppressive chemotherapy administration, and post-hematopoietic stem cell transplant (HSCT). As a cost-saving initiative, our institution switched from filgrastim to filgrastim-sndz for all indications starting in March 2016...
October 8, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28986190/incidence-and-risk-factors-for-nontuberculous-mycobacterial-infection-after-allogeneic-hematopoietic-cell-transplantation
#17
Jennifer Beswick, Elizabeth Shin, Fotios Michelis, Santhosh Thyagu, Auro Viswabandya, Jeffrey H Lipton, Hans Messner, Theodore K Marras, Dennis Kim
Allogenic hematopoietic stem cell transplant (HCT) recipients are at risk of many infections. Nontuberculous mycobacteria (NTM) are increasingly recognized as clinically significant pathogens in this population. We investigated the incidence and risk factors for NTM infection after allogeneic HCT. This retrospective cohort study included all patients with allogeneic HCT at our institution during 2001-2013. Patients who developed significant NTM infection (NTM disease) were identified. Multivariable modeling was used to identify risk factors for NTM disease, and a risk score model was constructed to identify high-risk patients...
October 3, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28983776/second-primary-cancer-after-liver-transplantation-in-hepatocellular-carcinoma-a-nationwide-population-based-study
#18
Jaesung Heo, O Kyu Noh, Young-Taek Oh, Mison Chun, Logyoung Kim
PURPOSE: The aim of this study is to evaluate prevalence of second primary cancer (SPC) among hepatocellular carcinoma (HCC) patients after liver transplantation (LT) by using nationwide claims data from South Korea. MATERIALS AND METHODS: The nationwide cohort included patients who were diagnosed with HCC and received LT from 1 January 2010 to 31 December 2014. We analyzed frequency and standardized incidence ratios (SIRs) to estimate the risk of SPC in HCC patients after LT...
October 5, 2017: Hepatology International
https://www.readbyqxmd.com/read/28979926/a-comparative-study-of-the-predictive-values-of-urinary-acute-kidney-injury-markers-angiogenin-and-kidney-injury-molecule-1-for-the-outcomes-of-kidney-allografts
#19
Quentin Tavernier, Claire Tinel, Marion Rabant, Lise Morin, Dany Anglicheau, Nicolas Pallet
BACKGROUND: Whether injury-related molecules in urines of individuals with ischemia-reperfusion injury (IRI) are independent predictors of graft outcomes and provide additional information compared with usual risk factors remains to be established. METHODS: We explored a cohort of 244 kidney transplant recipients who systematically had a urine collection 10 days after transplantation. The injury-related markers kidney injury molecule-1 (KIM-1) and angiogenin (ANG) levels in urines were measured...
September 2017: Transplantation Direct
https://www.readbyqxmd.com/read/28978532/tubular-maximum-phosphate-reabsorption-capacity-in-living-kidney-donors-is-independently-associated-with-one-year-recipient-gfr
#20
Marco van Londen, Brigitte M Aarts, Jan-Stephan F Sanders, Jan-Luuk Hillebrands, Stephan J L Bakker, Gerjan Navis, Martin H de Borst
The donor glomerular filtration rate (GFR) measured before kidney donation is a strong determinant of recipient graft outcome. No tubular function markers have been identified that can similarly be used in donors to predict recipient outcomes. In the current study we investigated whether the predonation tubular maximum reabsorption capacity of phosphate (TmP-GFR), which may be considered as a functional tubular marker in healthy kidney donors, is associated with recipient GFR at one year after transplantation, a key determinant of long-term outcome...
October 4, 2017: American Journal of Physiology. Renal Physiology
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