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https://www.readbyqxmd.com/read/29783202/feasibility-of-myocardial-pet-imaging-using-a-benzylguanidine-analog-meta-3-18-f-fluoropropyl-benzylguanidine-18-f-mfpbg
#1
Sang-Keun Woo, Byung Seok Moon, Bom Sahn Kim, Min Hwan Kim, Yong Jin Lee, Jae Ho Jung, Kyo Chul Lee, Youngho Seo, Wook Kim, Sang Moo Lim, Byung Chul Lee, Sang Eun Kim
INTRODUCTION: Global and regional sympathetic activity in the heart can be evaluated using [123 I]meta-iodobenzylguanidine ([123 I]mIBG) imaging. However, [123 I]mIBG is associated with low image spatial resolution and sensitivity in cardiac imaging. We investigated the capability of an F-18-labeled mIBG derivative, meta-(3-[18 F]fluoropropyl)benzylguanidine ([18 F]mFPBG), for identifying ischemic and viable myocardium in a rat model of myocardial infarction. MATERIALS AND METHODS: The ex vivo biodistribution and in vivo metabolic stability of [18 F]mFPBG were investigated in Sprague-Dawley rats...
May 3, 2018: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/29779430/intratumoral-immune-cells-expressing-pd-1-pd-l1-and-their-prognostic-implications-in-cancer-a-meta-analysis
#2
Younghoon Kim, Xianyu Wen, Nam Yun Cho, Gyeong Hoon Kang
BACKGROUND: The prognostic value of immune cells expressing programmed cell death 1 (PD-1) and PD-1 ligand 1 (PD-L1) in cancer are controversial, and the potential differential impact of using tissue microarrays and whole tissue sections to assess the positivity of immune cells has not been addressed. METHODS: The current study included 30 eligible studies with 7251 patients that evaluated the relationship between tumor-infiltrating lymphocytes expressing PD-1/PD-L1 and overall survival and disease-free survival, or progression-free survival...
May 1, 2018: International Journal of Biological Markers
https://www.readbyqxmd.com/read/29777352/forward-viewing-endoscope-for-ercp-in-patients-with-billroth-ii-gastrectomy-a-systematic-review-and-meta-analysis
#3
Tae Young Park, Chang Seok Bang, Sang Hyeon Choi, Young Joo Yang, Suk Pyo Shin, Ki Tae Suk, Gwang Ho Baik, Dong Joon Kim, Jai Hoon Yoon
BACKGROUND: The forward-viewing endoscope has been increasingly used to perform endoscopic retrograde cholangiopancreatography (ERCP) in patients who underwent Billroth II gastrectomy. This study intended to assess efficacy and safety of the forward-viewing endoscope for ERCP in Billroth II gastrectomy patients compared with conventional side-viewing endoscope using a systematic review and meta-analysis. METHODS: A systematic review was conducted for studies that evaluated the outcomes of ERCP for patients with Billroth II gastrectomy...
May 17, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29768927/ultrasonographic-optic-nerve-sheath-diameter-to-detect-increased-intracranial-pressure-in-adults-a-meta-analysis
#4
Sung-Eun Kim, Eun Pyo Hong, Heung Cheol Kim, Si Un Lee, Jin Pyeong Jeon
Background The optimal optic nerve sheath diameter (ONSD) cut-off for identifying increased intracranial pressure (IICP) remains unclear in adult patients. Purpose To validate the diagnostic accuracy of ultrasonographic (US) ONSD > 5.0 mm as a cut-off for detecting IICP by computed tomographic (CT) through a meta-analysis. Material and Methods A systemic literature review was performed of online databases from January 1990 to September 2017. A bivariate random-effects model was used to estimate pooled sensitivity, specificity, and diagnostic odds ratio (DOR) with 95% confidence intervals (CIs)...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29761234/prevalence-and-predictors-of-small-intestinal-bacterial-overgrowth-in-irritable-bowel-syndrome-a-systematic-review-and-meta-analysis
#5
REVIEW
Binrui Chen, John Jae-Woo Kim, Yawen Zhang, Lijun Du, Ning Dai
BACKGROUND: The reported prevalence of small intestinal bacterial overgrowth (SIBO) among individuals with irritable bowel syndrome (IBS) is highly variable. The aim of the study is to estimate the prevalence and identify predictors of SIBO in IBS. METHODS: PubMed, Cochrane Library, and EMBASE through July 2017 were searched to identify studies evaluating the prevalence of SIBO in IBS. The pooled prevalence of SIBO among individuals with IBS and the pooled odds ratio (OR) of SIBO among those with IBS compared with healthy controls were calculated...
May 14, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29759827/subcutaneous-versus-transvenous-implantable-defibrillator-therapy-a-meta-analysis-of-case-control-studies
#6
Indranill Basu-Ray, Jing Liu, Xiaoming Jia, Michael Gold, Kenneth Ellenbogen, James DiNicolantonio, András Komócsi, András Vorobcsuk, Jitae Kim, Hamid Afshar, Wilson Lam, Nilesh Mathuria, Mehdi Razavi, Abdi Rasekh, Mohammad Saeed
OBJECTIVES: This study aims to conduct a meta-analysis comparing efficacy and safety outcomes between subcutaneous implantable cardioverter-defibrillator (S-ICD) and transvenous implantable cardioverter-defibrillator (TV-ICD). BACKGROUND: The S-ICD was developed to minimize complications related to the conventional TV-ICD. Direct comparison of clinical outcomes between the 2 devices has been limited by varying patient characteristics and definitions of complications with no randomized trials completed comparing these systems...
December 26, 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29753295/major-depressive-disorder-in-epilepsy-clinics-a-meta-analysis
#7
REVIEW
Minjung Kim, Young-Soo Kim, Do-Hyung Kim, Tae-Won Yang, Oh-Young Kwon
BACKGROUND AND PURPOSE: Although depression is a frequent psychiatric comorbidity in people with epilepsy (PWE), its prevalence has been underestimated. Comorbid depression has negative impacts on treatment outcomes and quality of life (QOL). It also causes various problems in PWE, such as fatigue, irritability, and suicidality. This meta-analysis was performed to estimate the frequency of major depression disorder (MDD) in clinics managing PWE. METHODS: We searched MEDLINE, EMBASE, Cochrane Library, Web of Science, and SCOPUS to identify studies...
May 9, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29750799/population-specific-genetic-modification-of-huntington-s-disease-in-venezuela
#8
Michael J Chao, Kyung-Hee Kim, Jun Wan Shin, Diane Lucente, Vanessa C Wheeler, Hong Li, Jared C Roach, Leroy Hood, Nancy S Wexler, Laura B Jardim, Peter Holmans, Lesley Jones, Michael Orth, Seung Kwak, Marcy E MacDonald, James F Gusella, Jong-Min Lee
Modifiers of Mendelian disorders can provide insights into disease mechanisms and guide therapeutic strategies. A recent genome-wide association (GWA) study discovered genetic modifiers of Huntington's disease (HD) onset in Europeans. Here, we performed whole genome sequencing and GWA analysis of a Venezuelan HD cluster whose families were crucial for the original mapping of the HD gene defect. The Venezuelan HD subjects develop motor symptoms earlier than their European counterparts, implying the potential for population-specific modifiers...
May 11, 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29749132/prognostic-value-of-micrornas-in-coronary-artery-diseases-a-meta-analysis
#9
Ji Suk Kim, Kyoungjune Pak, Tae Sik Goh, Dae Cheon Jeong, Myoung Eun Han, Jihyun Kim, Sae Ock Oh, Chi Dae Kim, Yun Hak Kim
PURPOSE: Coronary artery diseases (CADs) are the leading causes of death in the world. Recent studies have reported that differentially expressed microRNAs (miRNAs) are associated with prognosis or major adverse cardiac events (MACEs) in CAD patients. In a previous meta-analysis, the authors made serious mistakes that we aimed to correct through an updated systematic review and meta-analysis of the prognostic value of altered miRNAs in patients with CADs. MATERIALS AND METHODS: We performed a systematic search of MEDLINE (from inception to May 2017) and EMBASE (from inception to May 2017) for English-language publications...
June 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29747617/pheochromocytoma-as-a-rare-cause-of-hypertension-in-a-46-x-i-x-q10-turner-syndrome-a-case-report-and-literature-review
#10
Ji Yeon Shin, Bo Hyun Kim, Young Keum Kim, Tae Hwa Kim, Eun Heui Kim, Min Jin Lee, Jong Ho Kim, Yun Kyung Jeon, Sang Soo Kim, In Joo Kim
BACKGROUND: Cardiovascular disease (CVD) presents the most serious health problems and contributes to the increased mortality in young women with Turner syndrome. Arterial hypertension in Turner syndrome patients is significantly more prevalent than that in a general age-matched control group. The aetiology of hypertension in Turner syndrome varies, even in the absence of cardiac anomalies and obvious structural renal abnormalities. Pheochromocytoma is an extremely rare cause among various etiologies for hypertension in patients with Turner syndrome...
May 10, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29738698/corticosteroids-reduce-risk-of-death-within-28-days-for-patients-with-severe-alcoholic-hepatitis-compared-with-pentoxifylline-or-placebo-a-meta-analysis-of-individual-data
#11
Alexandre Louvet, Mark R Thursz, Dong Joon Kim, Julien Labreuche, Stephen Atkinson, Sandeep Singh Sidhu, John G O'Grady, Evangelos Akriviadis, Emmanouil Sinakos, Robert L Carithers, Marie-José Ramond, Willis C Maddrey, Timothy R Morgan, Alain Duhamel, Philippe Mathurin
BACKGROUND & AIMS: We performed a meta-analysis of individual patient data from 11 randomized controlled trials comparing corticosteroids, pentoxifylline, or their combination in patients with severe alcoholic hepatitis. We compared the effects of the treatments on survival for 28 days or 6 months, and response to treatment based on the Lille model. METHODS: We searched PubMed for randomized controlled trials of pharmacologic therapy for severe alcoholic hepatitis...
May 5, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29735874/-effectiveness-of-non-pharmacologic-interventions-in-chemotherapy-induced-peripheral-neuropathy-a-systematic-review-and-meta-analysis
#12
REVIEW
Pok Ja Oh, You Lim Kim
PURPOSE: This study was conducted to evaluate the effectiveness of non-pharmacologic interventions in chemotherapy-induced peripheral neuropathy (CIPN). METHODS: PubMed, Cochrane Library CENTRAL, EMBASE, CINAHL, and several Korean databases (Until August 2017) were searched. The main search strategy combined terms for peripheral neuropathy and presence of neoplasms. The risk of bias was assessed using the Cochrane's Risk of Bias tool for randomized studies and the Risk of Bias Assessment tool for non-randomized studies...
April 2018: Journal of Korean Academy of Nursing
https://www.readbyqxmd.com/read/29733354/deep-resequencing-of-ulcerative-colitis-associated-genes-identifies-novel-variants-in-candidate-genes-in-the-korean-population
#13
Chang Mo Moon, Seung Won Kim, Jae Bum Ahn, Hyun Woo Ma, Xiumei Che, Tae Il Kim, Won Ho Kim, Jae Hee Cheon
Background: Genome-wide association studies and meta-analyses have revealed the genetic background of ulcerative colitis (UC) by identifying common variants. However, these variants do not fully explain the disease variance in UC. To identify novel variants, we performed deep resequencing of UC-associated genes in Korean UC patients and subsequently investigated the functional roles of identified susceptibility genes. Methods: We performed targeted deep resequencing of 108 genes in 24 Korean UC patients and then performed association analysis with data from 126 healthy controls...
May 4, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29731098/efficacy-and-safety-of-induction-therapy-in-kidney-transplantation-a-network-meta-analysis
#14
S D Hwang, J H Lee, S W Lee, K-M Park, J K Kim, M-J Kim, J H Song
BACKGROUND: Rejection and infection can occur after kidney transplantation and are important factors in preserving graft kidney function. The use of immunosuppressant agents in transplantation is therefore important, and the question of which induction therapy should be used as an immunosuppressant is controversial. OBJECTIVE: The goal of this study was to assess the comparative benefits and harms of various maintenance immunosuppressive induction agents in adults undergoing kidney transplantation by using a network meta-analysis and to generate rankings of the different immunosuppressive regimens according to their safety and efficacy...
May 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29729556/effects-of-aromatherapy-on-dysmenorrhea-a-systematic-review-and-meta-analysis
#15
Ji-Ah Song, Mi-Kyoung Lee, Eunsil Min, Mi-Eun Kim, Geraldine Fike, Myung-Haeng Hur
OBJECTIVE: Menstrual pain is not a disease, but it is a problem that periodically makes women uncomfortable during menstrual cycles. There has been a continuing effort to alleviate menstrual cramps in the medical field. Aromatherapy, one of the alternative complementary therapies, has been used as a way to alleviate menstrual cramps, but there is still little evidence of how to use it. Therefore, in this study, we tried to find and provide the evidence of relieving effects of menstrual cramps...
February 2, 2018: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29727742/cytokine-levels-in-febrile-seizure-patients-a-systematic-review-and-meta-analysis
#16
Aram Kwon, Byung Ok Kwak, Kyungmin Kim, Jongseok Ha, Soo-Jin Kim, Sun Hwan Bae, Jae Sung Son, Soo-Nyung Kim, Ran Lee
PURPOSE: Febrile seizures (FSs) are the most common form of childhood seizures. During infection, both pro-inflammatory and anti-inflammatory cytokines are produced. Complex interactions among immune-inflammatory process, cytokine activation, and genetic factors are involved in the pathogenesis of FSs. The association between cytokines and FSs during childhood is inconclusive due to inconsistent results reported in different studies. We performed a systematic review and meta-analysis to determine an association between cytokines and FS in children...
April 27, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29727132/changing-susceptibility-to-non-optimum-temperatures-in-japan-1972-2012-the-role-of-climate-demographic-and-socioeconomic-factors
#17
Yeonseung Chung, Daewon Yang, Antonio Gasparrini, Ana M Vicedo-Cabrera, Chris Fook Sheng Ng, Yoonhee Kim, Yasushi Honda, Masahiro Hashizume
BACKGROUND: Previous studies have shown that population susceptibility to non-optimum temperatures has changed over time, but little is known about the related time-varying factors that underlie the changes. OBJECTIVE: Our objective was to investigate the changing population susceptibility to non-optimum temperatures in 47 prefectures of Japan over four decades from 1972 to 2012, addressing three aspects: minimum mortality temperature (MMT) and heat- and cold-related mortality risks...
May 2, 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/29726345/mortality-and-morbidity-in-acutely-ill-adults-treated-with-liberal-versus-conservative-oxygen-therapy-iota-a-systematic-review-and-meta-analysis
#18
Derek K Chu, Lisa H-Y Kim, Paul J Young, Nima Zamiri, Saleh A Almenawer, Roman Jaeschke, Wojciech Szczeklik, Holger J Schünemann, John D Neary, Waleed Alhazzani
BACKGROUND: Supplemental oxygen is often administered liberally to acutely ill adults, but the credibility of the evidence for this practice is unclear. We systematically reviewed the efficacy and safety of liberal versus conservative oxygen therapy in acutely ill adults. METHODS: In the Improving Oxygen Therapy in Acute-illness (IOTA) systematic review and meta-analysis, we searched the Cochrane Central Register of Controlled Trials, MEDLINE, Embase, HealthSTAR, LILACS, PapersFirst, and the WHO International Clinical Trials Registry from inception to Oct 25, 2017, for randomised controlled trials comparing liberal and conservative oxygen therapy in acutely ill adults (aged ≥18 years)...
April 28, 2018: Lancet
https://www.readbyqxmd.com/read/29724255/optimizing-acupuncture-treatment-for-dry-eye-syndrome-a-systematic-review
#19
Bong Hyun Kim, Min Hee Kim, Se Hyun Kang, Hae Jeong Nam
BACKGROUND: In a former meta-analysis review, acupuncture was considered a potentially effective treatment for dry eye syndrome (DES), but there were heterogeneities among the outcomes. We updated the meta-analysis and conducted subgroup analysis to reduce the heterogeneity and suggest the most effective acupuncture method based on clinical trials. METHODS: We searched for randomized controlled trials (RCTs) in 10 databases (MEDLINE, EMBASE, CENTAL, AMED, SCOPUS, CNKI, Wangfang database, Oriental Medicine Advanced Searching Integrated System (OASIS), Koreamed, J-stage) and searched by hand to compare the effects of acupuncture and artificial tears (AT)...
May 3, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29723340/stroke-risk-among-patients-with-chronic-obstructive-pulmonary-disease-a-systematic-review-and-meta-analysis
#20
Yu Ree Kim, In Cheol Hwang, Yong Joo Lee, Eun Bee Ham, Dong Kyun Park, Sewan Kim
Increased stroke risk among chronic obstructive pulmonary disease patients has not yet been established. In this study, we conducted a systematic review and meta-analysis to assess stroke risk among chronic obstructive pulmonary disease patients. PubMed, EMBASE, and the Cochrane Library were systematically searched from database inception until December 31, 2016 to identify longitudinal observational studies that investigated the association between chronic obstructive pulmonary disease and stroke. Stroke risk was quantified by overall and subgroup analyses, and a pooled hazard ratio was calculated...
2018: Clinics
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