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https://www.readbyqxmd.com/read/29348891/clinicopathological-impacts-of-high-c-met-expression-in-head-and-neck-squamous-cell-carcinoma-a-meta-analysis-and-review
#1
Jung Han Kim, Bum Jun Kim, Hyeong Su Kim
High c-Met expression has been observed in head and neck squamous cell carcinoma (HNSCC). However, its clinicopathological impact remains controversial. We performed this meta-analysis to evaluate the pathologic and prognostic impacts of c-Met overexpression in patients with HNSCC. A systematic computerized search of the electronic databases was carried out. From 16 studies, 1,948 patients with HNSCC were included in the meta-analysis. Compared with HNSCCs showing low c-Met expression, tumors with high c-Met expression were significantly associated with higher rate of lymph node metastasis (odds ratio = 3...
December 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29347876/risk-of-overhydration-and-low-lean-tissue-index-as-measured-using-a-body-composition-monitor-in-patients-on-hemodialysis-a-systemic-review-and-meta-analysis
#2
Seun Deuk Hwang, Jin Ho Lee, Seoung Woo Lee, Joong Kyung Kim, Moon-Jae Kim, Joon Ho Song
Overhydration and sarcopenia, related to an individual's nutritional status, have been associated with increased cardiovascular mortality and poor prognosis in patients on hemodialysis. The purpose of this study was to investigate the prediction of overhydration and sarcopenia on mortality in patients on hemodialysis using a body composition monitor. We conducted a systematic review and meta-analysis using a random-effects model. We searched the Cochrane Central Register, OVID MEDLINE, EMBASE and PubMed databases for all studies published prior to December 9, 2016 and reviewed the reference lists of relevant reviews, registered trials and relevant conference proceedings...
November 2018: Renal Failure
https://www.readbyqxmd.com/read/29329789/lateral-lymph-node-metastasis-in-papillary-thyroid-carcinoma-a-systematic-review-and-meta-analysis-for-prevalence-risk-factors-and-location
#3
REVIEW
Yoon Kyoung So, Min-Ji Kim, Seonwoo Kim, Young-Ik Son
BACKGROUND: Lymph node metastasis (LNM) is frequent in papillary thyroid carcinoma (PTC) and is associated with a poor prognosis. Unlike central LNM (CLNM), there are few studies focusing on LLNM. We aimed to investigate the prevalence and the risk factors for LLNM, with its most prevalent sites. METHODS: We performed a comprehensive literature search using the PubMed and EMBASE databases for relevant studies published prior to November 2016 that examined the risk factors for LLNM...
January 9, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29328888/posterior-cruciate-ligament-reconstruction-with-transtibial-or-tibial-inlay-techniques-a-meta-analysis-of-biomechanical-and-clinical-outcomes
#4
Dong-Yeong Lee, Dong-Hee Kim, Hyun-Jung Kim, Hyeong-Sik Ahn, Tae-Ho Lee, Sun-Chul Hwang
BACKGROUND: Transtibial (TT) or tibial inlay (TI) techniques are commonly used for posterior cruciate ligament reconstruction (PCLR). However, the optimum method for PCLR after PCL injury remains debatable. Hypothesis/Purpose: The hypothesis was that TT and TI techniques would not show significant differences for all outcome measures. The purpose was to determine the biomechanical and clinical outcomes of TT and TI surgical techniques for PCLR. STUDY DESIGN: Meta-analysis; Level of evidence, 3...
January 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29327944/diagnostic-accuracy-of-f-18-fdg-pet-or-pet-ct-for-the-characterization-of-adrenal-masses-a-systematic-review-and-meta-analysis
#5
Seong-Jang Kim, Sang Woo Lee, Kyoungjune Pak, In-Ju Kim, Keunyoug Kim
OBJECTIVE: We aimed to explore the role of the diagnostic accuracy of F-18 fluorodeoxyglucose positron emission tomography (F-18 FDG PET) or positron emission tomography/computed tomography (PET/CT) for characterization of adrenal lesions through a systematic review and meta-analysis. METHODS: The MEDLINE, EMBASE, and Cochrane Library database, from the earliest available date of indexing through April 30, 2017, were searched for studies evaluating the diagnostic performance of F-18 FDG PET or PET/CT for characterization of adrenal lesions...
January 12, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29327290/the-diagnostic-performance-of-reduced-dose-ct-for-suspected-appendicitis-in-paediatric-and-adult-patients-a-systematic-review-and-diagnostic-meta-analysis
#6
Hee Mang Yoon, Chong Hyun Suh, Young Ah Cho, Jeong Rye Kim, Jin Seong Lee, Ah Young Jung, Jung Heon Kim, Jeong-Yong Lee, So Yeon Kim
OBJECTIVE: To evaluate the diagnostic performance of reduced-dose CT for suspected appendicitis. METHODS: A systematic search of the MEDLINE and EMBASE databases was carried out through to 10 January 2017. Studies evaluating the diagnostic performance of reduced-dose CT for suspected appendicitis in paediatric and adult patients were selected. Pooled summary estimates of sensitivity and specificity were calculated using hierarchical logistic regression modelling...
January 11, 2018: European Radiology
https://www.readbyqxmd.com/read/29324460/sex-differences-in-alzheimer-s-disease
#7
Keith R Laws, Karen Irvine, Tim M Gale
PURPOSE OF REVIEW: Women are more impacted by Alzheimer's disease than men - they are at significantly greater risk of developing Alzheimer's disease, and recent research shows that they also appear to suffer a greater cognitive deterioration than men at the same disease stage. The purpose of this article is to review recent studies on examining sex differences in cognitive function in Alzheimer's disease. RECENT FINDINGS: We searched electronically for articles, reviews and meta-analyses published between 1/2016 and 12/2017 and identified 298 articles on sex differences in cognition in Alzheimer's disease...
January 10, 2018: Current Opinion in Psychiatry
https://www.readbyqxmd.com/read/29319926/the-role-of-lymph-node-dissection-in-the-management-of-renal-cell-carcinoma-a-systematic-review-and-meta-analysis
#8
REVIEW
Bimal Bhindi, Christopher J D Wallis, Stephen A Boorjian, R Houston Thompson, Ann Farrell, Simon P Kim, Jose A Karam, Umberto Capitanio, Dragan Golijanin, Bradley C Leibovich, Boris Gershman
OBJECTIVES: To evaluate the role of retroperitoneal lymph node dissection (LND) in non-metastatic (M0) and metastatic (M1) renal cell carcinoma (RCC). PATIENTS AND METHODS: We searched Medline, EMBASE, Web of Science, and Scopus from database inception to August 29, 2017 for studies of patients who underwent partial or radical nephrectomy for M0 or M1 RCC. Two investigators independently selected studies for inclusion. Risk of bias was assessed using the Newcastle-Ottawa scale, Cochrane Collaboration tool, and NHLBI Quality Assessment Tool...
January 10, 2018: BJU International
https://www.readbyqxmd.com/read/29311653/meta-analysis-of-epigenome-wide-association-studies-of-cognitive-abilities
#9
Riccardo E Marioni, Allan F McRae, Jan Bressler, Elena Colicino, Eilis Hannon, Shuo Li, Diddier Prada, Jennifer A Smith, Letizia Trevisi, Pei-Chien Tsai, Dina Vojinovic, Jeannette Simino, Daniel Levy, Chunyu Liu, Michael Mendelson, Claudia L Satizabal, Qiong Yang, Min A Jhun, Sharon L R Kardia, Wei Zhao, Stefania Bandinelli, Luigi Ferrucci, Dena G Hernandez, Andrew B Singleton, Sarah E Harris, John M Starr, Douglas P Kiel, Robert R McLean, Allan C Just, Joel Schwartz, Avron Spiro, Pantel Vokonas, Najaf Amin, M Arfan Ikram, Andre G Uitterlinden, Joyce B J van Meurs, Tim D Spector, Claire Steves, Andrea A Baccarelli, Jordana T Bell, Cornelia M van Duijn, Myriam Fornage, Yi-Hsiang Hsu, Jonathan Mill, Thomas H Mosley, Sudha Seshadri, Ian J Deary
Cognitive functions are important correlates of health outcomes across the life-course. Individual differences in cognitive functions are partly heritable. Epigenetic modifications, such as DNA methylation, are susceptible to both genetic and environmental factors and may provide insights into individual differences in cognitive functions. Epigenome-wide meta-analyses for blood-based DNA methylation levels at ~420,000 CpG sites were performed for seven measures of cognitive functioning using data from 11 cohorts...
January 8, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29306894/income-and-obesity-what-is-the-direction-of-the-relationship-a-systematic-review-and-meta-analysis
#10
Tae Jun Kim, Olaf von dem Knesebeck
OBJECTIVE: It was repeatedly shown that lower income is associated with higher risks for subsequent obesity. However, the perspective of a potential reverse causality is often neglected, in which obesity is considered a cause for lower income, when obese people drift into lower-income jobs due to labour-market discrimination and public stigmatisation. This review was performed to explore the direction of the relation between income and obesity by specifically assessing the importance of social causation and reverse causality...
January 5, 2018: BMJ Open
https://www.readbyqxmd.com/read/29288038/brg1-is-correlated-with-poor-prognosis-in-colorectal-cancer
#11
Jung-Soo Pyo, Byoung Kwan Son, Dongwook Oh, Eun Kyung Kim
Brahma-related gene 1 (BRG1), a component of the chromatin-remodeling complex, regulates transcription by remodeling the chromatin structure. The present study aimed to elucidate the clinicopathological significance and prognostic role of BRG1 in colorectal cancer (CRC). We investigated the correlation between BRG1 expression and clinicopathological parameters, including prognosis, using immunohistochemistry on 266 archival paraffin-embedded CRC tissues. In addition, to confirm the prognostic role of BRG1 in malignant tumors, we performed a meta-analysis of nine eligible studies and the current study...
December 26, 2017: Human Pathology
https://www.readbyqxmd.com/read/29287962/lymphatic-interventions-for-chylothorax-a%C3%A2-systematic-review-and-meta-analysis
#12
Pyeong Hwa Kim, Jiaywei Tsauo, Ji Hoon Shin
PURPOSE: To perform a systematic review and meta-analysis of published studies to evaluate the efficacy of lymphatic interventions for chylothorax. MATERIALS AND METHODS: The MEDLINE, EMBASE, and Cochrane databases were searched for English-language studies until March 2017 that included patients with chylothorax treated with lymphangiography (LAG), thoracic duct embolization (TDE), or thoracic duct disruption (TDD). Exclusion criteria were as follows: a sample size of less than 10 patients, no extractable data, or data included in subsequent articles or duplicate reports...
December 26, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29279326/lactobacillus-reuteri-to-treat-infant-colic-a-meta-analysis
#13
REVIEW
Valerie Sung, Frank D'Amico, Michael D Cabana, Kim Chau, Gideon Koren, Francesco Savino, Hania Szajewska, Girish Deshpande, Christophe Dupont, Flavia Indrio, Silja Mentula, Anna Partty, Daniel Tancredi
CONTEXT: Lactobacillus reuteri DSM17938 has shown promise in managing colic, but conflicting study results have prevented a consensus on whether it is truly effective. OBJECTIVE: Through an individual participant data meta-analysis, we sought to definitively determine if L reuteri DSM17938 effectively reduces crying and/or fussing time in infants with colic and whether effects vary by feeding type. DATA SOURCES: We searched online databases (PubMed, Medline, Embase, the Cumulative Index to Nursing and Allied Health Literature, the Database of Abstracts of Reviews of Effects, and Cochrane), e-abstracts, and clinical trial registries...
December 26, 2017: Pediatrics
https://www.readbyqxmd.com/read/29278353/long-term-safety-of-bioresorbable-scaffolds-insights-from-a-network-meta-analysis-including-91-trials
#14
Si-Hyuck Kang, Bill D Gogas, Ki-Hyun Jeon, Jie-Suck Park, Wonjae Lee, Chang-Hwan Yoon, Jung-Won Suh, Seung-Sik Hwang, Tae-Jin Youn, In-Ho Chae, Hyo-Soo Kim
AIMS: To investigate the long-term safety and efficacy of biodegradable scaffolds and metallic stents. METHODS AND RESULTS: We analyzed a total of 91 randomized controlled trials with a mean follow-up of 3.7 years in 105,842 patients which compared 2 or more coronary metallic stents or biodegradable scaffolds and reported the long-term clinical outcomes (≥2 years). Network meta-analysis showed that patients treated with the Absorb bioresorbable vascular scaffold (BVS) had significantly higher risk of definite or probable scaffold thrombosis (ScT) compared to those treated with metallic DES...
December 26, 2017: EuroIntervention
https://www.readbyqxmd.com/read/29278292/aldh2-gene-g487a-polymorphism-and-coronary-artery-disease-a-meta-analysis-including-5644-participants
#15
Yan-Yan Li, Hui Wang, Jing-Jing Wu, Hyun Jun Kim, Xin-Xing Yang, Hong-Yu Geng, Ge Gong
Several studies indicate the mitochondrial Aldehyde Dehydrogenase-2 (ALDH2) gene G487A polymorphism may be correlated with coronary artery disease (CAD) susceptibility, but a clear consensus has yet to be reached. To elucidate the relationship between the ALDH2 gene G487A polymorphism and CAD within the Chinese population, a meta-analysis of 5644 subjects from nine individual studies was performed. Pooled odds ratios (ORs) and their corresponding 95% confidence intervals were assessed using random or fixed-effect models depending the heterogeneity existence or not...
December 26, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29275348/subgrouping-and-targeted-exercise-programmes-for-knee-and-hip-osteoarthritis-steer-oa-a-systematic-review-update-and-individual-participant-data-meta-analysis-protocol
#16
Melanie A Holden, Danielle L Burke, Jos Runhaar, Danielle van Der Windt, Richard D Riley, Krysia Dziedzic, Amardeep Legha, Amy L Evans, J Haxby Abbott, Kristin Baker, Jenny Brown, Kim L Bennell, Daniël Bossen, Lucie Brosseau, Kanda Chaipinyo, Robin Christensen, Tom Cochrane, Mariette de Rooij, Michael Doherty, Helen P French, Sheila Hickson, Rana S Hinman, Marijke Hopman-Rock, Michael V Hurley, Carol Ingram, Jesper Knoop, Inga Krauss, Chris McCarthy, Stephen P Messier, Donald L Patrick, Nilay Sahin, Laura A Talbot, Robert Taylor, Carolien H Teirlinck, Marienke van Middelkoop, Christine Walker, Nadine E Foster
INTRODUCTION: Knee and hip osteoarthritis (OA) is a leading cause of disability worldwide. Therapeutic exercise is a recommended core treatment for people with knee and hip OA, however, the observed effect sizes for reducing pain and improving physical function are small to moderate. This may be due to insufficient targeting of exercise to subgroups of people who are most likely to respond and/or suboptimal content of exercise programmes. This study aims to identify: (1) subgroups of people with knee and hip OA that do/do not respond to therapeutic exercise and to different types of exercise and (2) mediators of the effect of therapeutic exercise for reducing pain and improving physical function...
December 22, 2017: BMJ Open
https://www.readbyqxmd.com/read/29274758/efficacy-and-safety-outcomes-of-direct-oral-anticoagulants-and-amiodarone-in-patients-with-atrial-fibrillation
#17
Florentino Lupercio, Jorge Romero, Bradley Peltzer, Carola Maraboto, David Briceno, Pedro Villablanca, Kevin Ferrick, Jay N Gross, Soo Kim, John Fisher, Luigi Di Biase, Andrew Krumerman
BACKGROUND: Direct oral anticoagulants (DOACs) and amiodarone are widely used in the treatment of non-valvular atrial fibrillation. The DOACs are P-glycoprotein (P-gp) and cytochrome p-450 (CYP3A4) substrates. DOAC levels may be increased by the concomitant use of potent dual P-gp/CYP3A4 inhibitors such as amiodarone, which can potentially translate into adverse clinical outcomes. We aimed to assess the efficacy and safety of drug-drug interaction by the concomitant use of DOACs and amiodarone...
December 21, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/29246006/significance-of-ki-67-in-non-muscle-invasive-bladder-cancer-patients-a-systematic-review-and-meta-analysis
#18
Kyungtae Ko, Chang Wook Jeong, Cheol Kwak, Hyeon Hoe Kim, Ja Hyeon Ku
Purpose: This meta-analysis evaluated the prognostic significance of Ki-67 in non-muscle invasive bladder cancer (NMIBC). Materials and Methods: We selected 39 articles including 5,229 patients from Embase, Scopus, and PubMed searches. The primary outcomes, recurrence-free survival (RFS), progression-free survival (PFS), disease-specific survival (DSS), and overall survival (OS) were determined using time-to event hazard ratios (HRs) with 95% confidence intervals (CIs)...
November 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/29235944/experience-of-touch-in-health-care-a-meta-ethnography-across-the-health-care-professions
#19
Martina Ann Kelly, Lara Nixon, Caitlin McClurg, Albert Scherpbier, Nigel King, Tim Dornan
Touch mediates health professionals' interactions with patients. Different professionals have reported their practices but what is currently lacking is a well-theorized, interprofessional synthesis. We systematically searched eight databases, identified 41 studies in seven professions-nursing (27), medicine (4), physiotherapy (5), osteopathy (1), counseling (2), psychotherapy (1), dentistry (1)-and completed a meta-ethnographic line-of-argument synthesis. This found that touch is caring, exercises power, and demands safe space...
January 2018: Qualitative Health Research
https://www.readbyqxmd.com/read/29233562/comparison-of-radiation-therapy-modalities-for-hepatocellular-carcinoma-with-portal-vein-thrombosis-a-meta-analysis-and-systematic-review
#20
Chai Hong Rim, Chul Yong Kim, Dae Sik Yang, Won Sup Yoon
PURPOSE: We performed a meta-analysis and systematic review to compare the radiotherapy (RT) modalities for hepatocellular carcinoma (HCC) with portal vein thrombosis (PVT). MATERIALS AND METHODS: We searched the PubMed, EMBASE, Medline, and Cochrane library databases. The primary endpoint was the 1-year overall survival (OS), and response rate (RR), local control (LC), 2-year OS, and grade ≥3 toxicity incidence were evaluated as secondary endpoints. RESULTS: Thirty-seven studies comprising 2513 patients were included...
December 9, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
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