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https://www.readbyqxmd.com/read/28427576/bleeding-related-deaths-in-relation-to-the-duration-of-dual-antiplatelet-therapy-after-coronary-stenting
#1
Tullio Palmerini, Letizia Bacchi Reggiani, Diego Della Riva, Mattia Romanello, Fausto Feres, Alexandre Abizaid, Martine Gilard, Marie-Claude Morice, Marco Valgimigli, Myeong-Ki Hong, Byeong-Keuk Kim, Yangsoo Jang, Hyo-Soo Kim, Kyung Woo Park, Antonio Colombo, Alaide Chieffo, Jung-Min Ahn, Seung-Jung Park, Stefanie Schüpke, Adnan Kastrati, Gilles Montalescot, Philippe Gabriel Steg, Abdourahmane Diallo, Eric Vicaut, Gerard Helft, Giuseppe Biondi-Zoccai, Bo Xu, Yaling Han, Philippe Genereux, Deepak L Bhatt, Gregg W Stone
BACKGROUND: Although some randomized controlled trials (RCTs) and meta-analyses have suggested that prolonged dual-antiplatelet therapy (DAPT) may be associated with increased mortality, the mechanistic underpinnings of this association remain unclear. OBJECTIVES: The aim of this study was to analyze the associations among bleeding, mortality, and DAPT duration after drug-eluting stent implantation in a meta-analysis of RCTs. METHODS: RCTs comparing different DAPT durations after drug-eluting stent placement were sought through the MEDLINE, Embase, and Cochrane databases and the proceedings of international meetings...
April 25, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28423646/tim-3-is-a-potential-prognostic-marker-for-patients-with-solid-tumors-a-systematic-review-and-meta-analysis
#2
Yang Zhang, Pengcheng Cai, Tao Liang, Lin Wang, Lihua Hu
Accumulated studies have demonstrated the important role of T cell immunoglobulin- and mucin-domain-containing molecule-3 (TIM-3) in various solid tumors and indicated its correlation with patients' survival. To further verify the prognostic significance of TIM-3 in cancer patients and its correlation with tumor, we performed this meta-analysis including seven studies searched from PubMed, Web of Science, and Embase till July 2016. A total of 869 patients were used to analyze the association between TIM-3 expression and patients' overall survival (OS)...
March 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28415770/human-8-oxoguanine-dna-glycosylase-gene-polymorphism-ser326cys-and-cancer-risk-updated-meta-analysis
#3
Sang Wook Kang, Su Kang Kim, Hae Jeong Park, Joo-Ho Chung, Ju Yeon Ban
Genetic polymorphism of human 8-oxoguanine glycosylase 1 (hOGG1) has been reported to have a relationship with the risk of the development of various cancers. Many studies have described the influence of Ser326Cys polymorphism of the hOGG1 gene on cancer susceptibility. However, the results have remained inconclusive and controversial. Therefore, we performed a meta-analysis to more precisely determine the relationship between the hOGG1 polymorphism and the development of cancer.Electronic databases including PubMed, Embase, Google Scholar, and the Korean Studies Information Service System (KISS) were searched...
March 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28415706/the-role-of-targeted-agents-in-the-adjuvant-treatment-of-colon-cancer-a-meta-analysis-of-randomized-phase-iii-studies-and-review
#4
Bum Jun Kim, Jae Ho Jeong, Jung Han Kim, Hyeong Su Kim, Hyun Joo Jang
There has been debate as to whether targeted agents have beneficial effect when added to adjuvant chemotherapy for patient with colon cancer. We conducted this meta-analysis to investigate the role of targeted agents in the adjuvant treatment of colon cancer. We searched PubMed, MEDLINE, EMBASE, and the Cochrane Library databases. We included phase III trials with the data of disease-free survival (DFS) and adverse events (AEs) of adjuvant treatment with targeted agents. From 5 eligible studies, a total of 9,991 patients with resected colon cancer were included in the meta-analysis of hazard ratio (HR) for 3-year DFS and odds ratio (OR) for grade 3 or higher AEs...
March 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28413188/circulating-proprotein-convertase-subtilisin-kexin-type-9-pcsk9-concentration-and-risk-of-cardiovascular-events%C3%A3-systematic-review-and-meta-analysis-of-prospective-studies
#5
Yunjun Xiao, Chaoqiong Peng, Wei Huang, Jinzhou Zhang, Yang Gao, Jean H Kim, Eng-Kiong Yeoh, Xuefen Su
BACKGROUND: Previous studies have not found a consistent association between circulating proprotein convertase subtilisin/kexin type 9 (PCSK9) and the risk of cardiovascular events. The aim of this meta-analysis was to evaluate this association in prospective studies.Methods and Results:A systematic search of prospective studies published through October 2016 was carried out in order to identify studies that met pre-specified inclusion criteria. After independent data extraction, summary relative risks were calculated using random-effects models...
April 11, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28412063/diagnostic-performance-of-magnetic-resonance-imaging-for-the-detection-of-bone-metastasis-in-prostate-cancer-a-systematic-review-and-meta-analysis
#6
Sungmin Woo, Chong Hyun Suh, Sang Youn Kim, Jeong Yeon Cho, Seung Hyup Kim
CONTEXT: Magnetic resonance imaging (MRI) has been tested for detecting bone metastasis and has shown promising results. Yet, consensus has not been reached regarding whether it can replace the role of bone scintigraphy in this clinical setting or not. OBJECTIVE: To review the diagnostic performance of contemporary (≥1.5 T) MRI for the detection of bone metastasis in patients with prostate cancer. EVIDENCE ACQUISITION: MEDLINE and EMBASE were searched up to January 22, 2017...
April 12, 2017: European Urology
https://www.readbyqxmd.com/read/28411259/cerebral-embolic-protection-devices-during-transcatheter-aortic-valve-implantation-systematic-review-and-meta-analysis
#7
Rodrigo Bagur, Karla Solo, Saleh Alghofaili, Luis Nombela-Franco, Chun Shing Kwok, Samual Hayman, Reed A Siemieniuk, Farid Foroutan, Frederick A Spencer, Per O Vandvik, Tim G Schäufele, Mamas A Mamas
BACKGROUND AND PURPOSE: Silent ischemic embolic lesions are common after transcatheter aortic valve implantation (TAVI). The use of embolic protection devices (EPD) may reduce the occurrence of these embolic lesions. Thus, a quantitative overview and credibility assessment of the literature was necessary to draw a robust message about EPD. Therefore, the aim of this meta-analysis was to study whether the use of EPD reduces silent ischemic and clinically evident cerebrovascular events associated with TAVI...
April 14, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28408440/global-cardiovascular-and-renal-outcomes-of-reduced-gfr
#8
Bernadette Thomas, Kunihiro Matsushita, Kalkidan Hassen Abate, Ziyad Al-Aly, Johan Ärnlöv, Kei Asayama, Robert Atkins, Alaa Badawi, Shoshana H Ballew, Amitava Banerjee, Lars Barregård, Elizabeth Barrett-Connor, Sanjay Basu, Aminu K Bello, Isabela Bensenor, Jaclyn Bergstrom, Boris Bikbov, Christopher Blosser, Hermann Brenner, Juan-Jesus Carrero, Steve Chadban, Massimo Cirillo, Monica Cortinovis, Karen Courville, Lalit Dandona, Rakhi Dandona, Kara Estep, João Fernandes, Florian Fischer, Caroline Fox, Ron T Gansevoort, Philimon N Gona, Orlando M Gutierrez, Samer Hamidi, Sarah Wulf Hanson, Jonathan Himmelfarb, Simerjot K Jassal, Sun Ha Jee, Vivekanand Jha, Aida Jimenez-Corona, Jost B Jonas, Andre Pascal Kengne, Yousef Khader, Young-Ho Khang, Yun Jin Kim, Barbara Klein, Ronald Klein, Yoshihiro Kokubo, Dhaval Kolte, Kristine Lee, Andrew S Levey, Yongmei Li, Paulo Lotufo, Hassan Magdy Abd El Razek, Walter Mendoza, Hirohito Metoki, Yejin Mok, Isao Muraki, Paul M Muntner, Hiroyuki Noda, Takayoshi Ohkubo, Alberto Ortiz, Norberto Perico, Kevan Polkinghorne, Rajaa Al-Radaddi, Giuseppe Remuzzi, Gregory Roth, Dietrich Rothenbacher, Michihiro Satoh, Kai-Uwe Saum, Monika Sawhney, Ben Schöttker, Anoop Shankar, Michael Shlipak, Diego Augusto Santos Silva, Hideaki Toyoshima, Kingsley Ukwaja, Mitsumasa Umesawa, Stein Emil Vollset, David G Warnock, Andrea Werdecker, Kazumasa Yamagishi, Yuichiro Yano, Naohiro Yonemoto, Maysaa El Sayed Zaki, Mohsen Naghavi, Mohammad H Forouzanfar, Christopher J L Murray, Josef Coresh, Theo Vos
The burden of premature death and health loss from ESRD is well described. Less is known regarding the burden of cardiovascular disease attributable to reduced GFR. We estimated the prevalence of reduced GFR categories 3, 4, and 5 (not on RRT) for 188 countries at six time points from 1990 to 2013. Relative risks of cardiovascular outcomes by three categories of reduced GFR were calculated by pooled random effects meta-analysis. Results are presented as deaths for outcomes of cardiovascular disease and ESRD and as disability-adjusted life years for outcomes of cardiovascular disease, GFR categories 3, 4, and 5, and ESRD...
April 13, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28402017/asthma-education-for-school-staff
#9
REVIEW
Kayleigh M Kew, Robin Carr, Tim Donovan, Morris Gordon
BACKGROUND: Teachers and school staff should be competent in managing asthma in schools. Demonstrated low levels of asthma knowledge mean that staff may not know how best to protect a child with asthma in their care, or may fail to take appropriate action in the event of a serious attack. Education about asthma could help to improve this knowledge and lead to better asthma outcomes for children. OBJECTIVES: To assess the effectiveness and safety of asthma education programmes for school staff, and to identify content and attributes underpinning them...
April 12, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28401630/causation-or-selection-examining-the-relation-between-education-and-overweight-obesity-in-prospective-observational-studies-a-meta-analysis
#10
REVIEW
T J Kim, N M Roesler, O von dem Knesebeck
Numerous studies have investigated the association between education and overweight/obesity. Yet less is known about the relative importance of causation (i.e. the influence of education on risks of overweight/obesity) and selection (i.e. the influence of overweight/obesity on the likelihood to attain education) hypotheses. A systematic review was performed to assess the linkage between education and overweight/obesity in prospective studies in general populations. Studies were searched within five databases, and study quality was appraised with the Newcastle-Ottawa scale...
April 12, 2017: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28395505/comparison-of-the-efficacy-and-safety-of-single-versus-double-balloon-enteroscopy-performed-by-endoscopist-experts-in-single-balloon-enteroscopy-a-single-center-experience-and-meta-analysis
#11
Tae Jun Kim, Eun Ran Kim, Dong Kyung Chang, Young-Ho Kim, Sung Noh Hong
Background/Aims: Studies concerning the efficacy and safety of single-balloon enteroscopy (SBE) compared with that of double-balloon enteroscopy (DBE) often appear to be conflicting. However, previous studies were performed by endoscopists who were less experienced in SBE compared with DBE. Methods: We performed a retrospective analysis of SBE and DBE data performed by a single enteroscopist, with expertise in SBE, using a prospective balloon-assisted enteroscopy registry from 2013 to 2015...
April 11, 2017: Gut and Liver
https://www.readbyqxmd.com/read/28385611/description-of-the-eurotarget-cohort-a-european-collaborative-project-on-targeted-therapy-in-renal-cell-cancer-genetic-and-tumor-related-biomarkers-for-response-and-toxicity
#12
Loes F M van der Zanden, Sita H Vermeulen, Arna Oskarsdottir, Jake S F Maurits, Meta H M Diekstra, Valentin Ambert, Anne Cambon-Thomsen, Daniel Castellano, Achim Fritsch, Jesus Garcia Donas, Rosa Guarch Troyas, Henk-Jan Guchelaar, Arndt Hartmann, Christina Hulsbergen-van de Kaa, Ulrich Jaehde, Kerstin Junker, Anna Martinez-Cardus, Gisli Masson, Jeannette Oosterwijk-Wakka, Marius T Radu, Thorunn Rafnar, Cristina Rodriguez-Antona, Max Roessler, Rob Ruijtenbeek, Kari Stefansson, Anne Warren, Lodewyk Wessels, Tim Eisen, Lambertus A L M Kiemeney, Egbert Oosterwijk
OBJECTIVE: For patients with metastatic renal cell cancer (mRCC), treatment choice is mainly based on clinical parameters. With many treatments available and the limited response to treatment and associated toxicities, there is much interest in identifying better biomarkers for personalized treatment. EuroTARGET aims to identify and characterize host- and tumor-related biomarkers for prediction of response to tyrosine kinase inhibitor therapy in mRCC. Here, we describe the EuroTARGET mRCC patient cohort...
April 3, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28384544/design-synthesis-and-structure-activity-relationship-study-of-halogen-containing-2-benzylidene-1-indanone-derivatives-for-inhibition-of-lps-stimulated-ros-production-in-raw-264-7-macrophages
#13
Aarajana Shrestha, Hye Jin Oh, Mi Jin Kim, Nirmala Tilija Pun, Til Bahadur Thapa Magar, Ganesh Bist, Hongseok Choi, Pil-Hoon Park, Eung-Seok Lee
As a continuous effort to discover new potential anti-inflammatory agents, we systematically designed and synthesized sixty-one 2-benzylidene-1-indanone derivatives with structural modification of chalcone, and evaluated their inhibitory activity on LPS-stimulated ROS production in RAW 264.7 macrophages. Systematic structure-activity relationship study revealed that hydroxyl group in C-5, C-6, or C-7 position of indanone moiety, and ortho-, meta-, or para-fluorine, trifluoromethyl, trifluoromethoxy, and bromine functionalities in phenyl ring are important for inhibition of ROS production in LPS-stimulated RAW 264...
March 27, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28382799/elevated-plasma-fibrinogen-levels-and-prognosis-of-epithelial-ovarian-cancer-a-cohort-study-and-meta-analysis
#14
Yanlin Luo, Hee Seung Kim, Miseon Kim, Maria Lee, Yong Sang Song
OBJECTIVE: To evaluate the effect of elevated plasma fibrinogen levels on the prognosis of epithelial ovarian cancer (EOC). METHODS: We reviewed the data of 217 patients with advanced-stage EOC between 2000 and 2012, and investigated the prognostic role of elevated plasma fibrinogen levels compared with serum CA-125 levels, neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR). For further evaluation, we performed a meta-analysis using 5 cohort studies published to July 2015, including our cohort study after a literature review...
May 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/28382531/resistance-training-for-glycemic-control-muscular-strength-and-lean-body-mass-in-old-type-2-diabetic-patients-a-meta-analysis
#15
REVIEW
JungHoon Lee, DoHoun Kim, ChangKeun Kim
INTRODUCTION: Type 2 diabetes (T2D) in elderly patients is associated with accelerated loss of skeletal muscle mass and strength. However, there are few meta-analysis reviews which investigate the effects of resistance training (RT) on glycemic control and skeletal muscle in the patients. METHODS: Three electronic databases were searched (from the earliest date available to November 2016). Studies were included according to the inclusion criteria: T2D patients at least 60 years old, fasting plasma glucose of at least 7...
April 5, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/28378562/early-rehabilitation-in-elderly-after-arthroplasty-versus-internal-fixation-for-unstable-intertrochanteric-fractures-of-femur-systematic-review-and-meta-analysis
#16
Jun Il Yoo, Yong Chan Ha, Jae Young Lim, Hyun Kang, Byung Ho Yoon, Hyunho Kim
The purpose of this study was to compare the outcomes focusing on the functional outcome and clinical results of replacement arthroplasty (AP) vs. internal fixation (IF) for the treatment of unstable intertrochanteric femoral fracture in elderly. Systematic review and meta-analysis were performed on 10 available clinical studies (2 randomized controlled trials and 8 comparative studies). Subgroup analysis was performed by type of methodological quality. Partial weight bearing time in AP group was earlier than that in IF group (SMD = -0...
May 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28374042/efficacy-and-safety-of-tranexamic-acid-in-melasma-a-meta-analysis-and-systematic-review
#17
Hyun Jung Kim, Seok Hoon Moon, Sang Hyun Cho, Jeong Deuk Lee, Hei Sung Kim
Tranexamic acid is a novel treatment option for melasma; however, there is no consensus on its use. This systematic review searched major databases for relevant publications to March 2016. Eleven studies with 667 participants were included. Pooled data from tranexamic acid-only observational studies with pre- and post-treatment Melasma Area and Severity Index (MASI) showed a decrease of 1.60 in MASI (95% confidence interval (CI), 1.20-2.00; p < 0.001) after treat-ment with tranexamic acid. The addition of tranexamic acid to routine treatment modalities resulted in a further decrease in MASI of 0...
April 4, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28373906/a-meta-analysis-of-palliative-treatment-of-pancreatic-cancer-with-high-intensity-focused-ultrasound
#18
Susan Dababou, Cristina Marrocchio, Jarrett Rosenberg, Rachelle Bitton, Kim Butts Pauly, Alessandro Napoli, Joo Ha Hwang, Pejman Ghanouni
BACKGROUND: Pancreatic adenocarcinoma is currently the fourth-leading cause of cancer-related death. Up to 60-90% of patients with advanced disease suffer cancer-related pain, severely impacting their quality of life. Current management involves primarily pharmacotherapy with opioid narcotics and celiac plexus neurolysis; unfortunately, both approaches offer transient relief and cause undesired side-effects. High intensity focused ultrasound (HIFU) is a non-invasive thermal ablation technique that has been used to treat pancreatic cancer...
2017: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/28372674/the-sedative-effects-of-the-intranasal-administration-of-dexmedetomidine-in-children-undergoing-surgeries-compared-to-other-sedation-methods-a-systematic-review-and-meta-analysis
#19
Hyun Jung Kim, Woo Jong Shin, Suin Park, Hyeong Sik Ahn, Jae Hoon Oh
STUDY OBJECTIVE: Administration of intranasal dexmedetomidine for sedation is comfortable and effective in children who are afraid of needles, and it offers efficient sedation similar to that of intravenous administration. We performed a systematic review and meta-analysis to evaluate the clinical effects of the pre-procedural administration of intranasal dexmedetomidine. DESIGN: We identified randomized controlled trials (RCTs) that compared intranasal dexmedetomidine administration to other administration methods of various sedatives or placebo from MEDLINE, EMBASE, Cochrane, KoreaMed and hand searches of trial registries...
May 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28371524/accumulation-of-adverse-childhood-events-and-overweight-in-children-a-systematic-review-and-meta-analysis
#20
REVIEW
Leonie K Elsenburg, Kim J E van Wijk, Aart C Liefbroer, Nynke Smidt
OBJECTIVE: This study systematically summarizes the evidence of all observational studies investigating the relation between accumulation of adverse life events and measures of overweight in children <18 years. METHODS: MEDLINE, Embase, PsycINFO, and CINAHL were systematically searched (last search date 18 February 2015). The Newcastle-Ottawa Scale was used for methodological quality assessment. Study estimates were pooled using a random-effects model, and sources of heterogeneity were explored (PROSPERO registration number CRD42014014927)...
April 3, 2017: Obesity
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