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Lactate AND Sulfonyl urea

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https://www.readbyqxmd.com/read/15050641/sulfonyl-phenyl-ureido-benzamidines-a-novel-structural-class-of-potent-antimalarial-agents
#1
Johann Leban, Stefano Pegoraro, Matthias Dormeyer, Michael Lanzer, Andrea Aschenbrenner, Bernd Kramer
The high throughput in silico screening of a virtual library into the structure of the P. falciparum lactate dehydrogenase (LDH) with the 4SCan technology yielded a series of biphenyl urea compounds. These were chemically optimized to a new structural class of potent antimalarial agents. The compounds did not inhibit plasmodium LDH enough to fully explain their potency. Therefore we conclude that an unknown mode of action may be the cause of the antimalarial activity.
April 19, 2004: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/4565414/-antabus-syndrome-under-sulfonyl-urea-treatment
#2
W Dölle, M Lahn
No abstract text is available yet for this article.
October 1972: Der Internist
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