Zixuan Chen, E Yiwen, Jun Xiong, Weike Li, Xuemei Chen, Na Li, Jing Long, Chao Tong, Junlin He, Fangfang Li, Cuihua Zhang, Yingxiong Wang, Rufei Gao
Pregnancy complications are more likely to occur in obese women because of defective decidualization. However, the specific mechanism of glycolysis in decidual modulation associated with obesity remains unknown. Therefore, we explored the role of glycolysis in the endometrium of obese pregnant mice during decidualization. C57BL/6J mice were fed a high-fat diet (HFD) to induce obesity. All obesity related parameters were significantly higher in the HFD mice than control. Furthermore, the HFD mice had fewer implantation sites, a smaller decidual area growth, and decreased decidualization marker protein expression than control...
February 3, 2023: Biochimica et Biophysica Acta. Molecular Basis of Disease