keyword
https://read.qxmd.com/read/38001993/dopamine-in-the-regulation-of-glucose-homeostasis-pathogenesis-of-type-2-diabetes-and-chronic-conditions-of-impaired-dopamine-activity-metabolism-implication-for-pathophysiological-and-therapeutic-purposes
#1
REVIEW
Giuseppe Lisco, Anna De Tullio, Michele Iovino, Olga Disoteo, Edoardo Guastamacchia, Vito Angelo Giagulli, Vincenzo Triggiani
Dopamine regulates several functions, such as voluntary movements, spatial memory, motivation, sleep, arousal, feeding, immune function, maternal behaviors, and lactation. Less clear is the role of dopamine in the pathophysiology of type 2 diabetes mellitus (T2D) and chronic complications and conditions frequently associated with it. This review summarizes recent evidence on the role of dopamine in regulating insular metabolism and activity, the pathophysiology of traditional chronic complications associated with T2D, the pathophysiological interconnection between T2D and chronic neurological and psychiatric disorders characterized by impaired dopamine activity/metabolism, and therapeutic implications...
November 7, 2023: Biomedicines
https://read.qxmd.com/read/37491462/the-role-of-ppar-%C3%AE-in-memory-deficits-induced-by-prenatal-and-lactation-alcohol-exposure-in-mice
#2
JOURNAL ARTICLE
Alba Garcia-Baos, Antoni Pastor, Ines Gallego-Landin, Rafael de la Torre, Ferran Sanz, Olga Valverde
Patients diagnosed with fetal alcohol spectrum disorder (FASD) show persistent cognitive disabilities, including memory deficits. However, the neurobiological substrates underlying these deficits remain unclear. Here, we show that prenatal and lactation alcohol exposure (PLAE) in mice induces FASD-like memory impairments. This is accompanied by a reduction of N-acylethanolamines (NAEs) and peroxisome proliferator-activated receptor gamma (PPAR-γ) in the hippocampus specifically in a childhood-like period (at post-natal day (PD) 25)...
July 25, 2023: Molecular Psychiatry
https://read.qxmd.com/read/37140018/effects-of-heat-shock-protein-90-on-complement-activation-in-myocardial-ischemia-reperfusion-injury-after-pioglitazone-preconditioning
#3
JOURNAL ARTICLE
Dongxiao Wang, Shitao He, Guoqiang Zhong, Jianjun Meng, Qi Bi, Ronghui Tu
BACKGROUND: Heat shock protein 90 (HSP90) appears to have a pivotal function in ischemic preconditioning. Pioglitazone preconditioning (PioC) attenuates myocardial ischemia/reperfusion (I/R) injuries. OBJECTIVES: The current study aims to investigate the role of HSP90, complement C3 and C5a, and nuclear factor kappa-B (NF-κB) in PioC-induced cardioprotection. MATERIAL AND METHODS: A total of 80 rats were randomly categorized into 4 groups, as follows: sham, I/R, PioC, and PioC+HSP90 inhibitor geldanamycin (PioC+GA)...
May 4, 2023: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/36740105/dysregulated-glycolysis-underpins-high-fat-associated-endometrial-decidualization-impairment-during-early-pregnancy-in-mice
#4
JOURNAL ARTICLE
Zixuan Chen, E Yiwen, Jun Xiong, Weike Li, Xuemei Chen, Na Li, Jing Long, Chao Tong, Junlin He, Fangfang Li, Cuihua Zhang, Yingxiong Wang, Rufei Gao
Pregnancy complications are more likely to occur in obese women because of defective decidualization. However, the specific mechanism of glycolysis in decidual modulation associated with obesity remains unknown. Therefore, we explored the role of glycolysis in the endometrium of obese pregnant mice during decidualization. C57BL/6J mice were fed a high-fat diet (HFD) to induce obesity. All obesity related parameters were significantly higher in the HFD mice than control. Furthermore, the HFD mice had fewer implantation sites, a smaller decidual area growth, and decreased decidualization marker protein expression than control...
February 3, 2023: Biochimica et Biophysica Acta. Molecular Basis of Disease
https://read.qxmd.com/read/36708143/inactivation-of-mitochondrial-pyruvate-carrier-promotes-nlrp3-inflammasome-activation-and-gout-development-via-metabolic-reprogramming
#5
JOURNAL ARTICLE
Lih-Chyang Chen, Yu-Jen Chen, Hsin-An Lin, Wu-Chien Chien, Kuen-Jou Tsai, Chi-Hsiang Chung, Jui-Yang Wang, Chien-Chou Chen, Nan-Shih Liao, Chieh-Tien Shih, Yi-Ying Lin, Chi-Ning Huang, David M Ojcius, Kuo-Yang Huang, Hsin-Chung Lin
The NLRP3 inflammasome plays a crucial role in innate immunity and is involved in the pathogenesis of autoinflammatory diseases. Glycolysis regulates NLRP3 inflammasome activation in macrophages. However, how lactic acid fermentation and pyruvate oxidation controlled by the mitochondrial pyruvate carrier (MPC) affect NLRP3 inflammasome activation and autoinflammatory disease remains elusive. We found that inactivation of MPC with genetic depletion or pharmacological inhibitors, MSDC-0160 or pioglitazone, increased NLRP3 inflammasome activation and IL-1β secretion in macrophages...
January 28, 2023: Immunology
https://read.qxmd.com/read/36384763/drugs-for-type-2-diabetes
#6
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
November 14, 2022: Medical Letter on Drugs and Therapeutics
https://read.qxmd.com/read/36104240/pioglitazone-protects-against-hypoxia-induced-cardiomyocyte-apoptosis-through-inhibiting-nlrp3-caspase-1-pathway-in-vivo-and-in-vitro
#7
JOURNAL ARTICLE
Hui Zhang, Caihong Huang, Dong Zhang, Yan Zhu
This study aims to explore the underlying mechanisms of how Pioglitazone (Pio) affects myocardial ischemia-reperfusion (I/R) injury. In this study, after pretreatment of Pio, the pathologic change of myocardial tissues was measured via hematoxylin and eosin staining. The release of lactate dehydrogenase (LDH), superoxide dismutase (SOD), and nitric oxide (NO) were measured. The cardiomyocyte apoptosis was detected via TUNEL assay and flow cytometry assay. The mitochondrial membrane potential (ΔΨm) was estimated using the JC-1 probe...
September 14, 2022: International Heart Journal
https://read.qxmd.com/read/35634337/alcohol-induced-glycolytic-shift-in-alveolar-macrophages-is-mediated-by-hypoxia-inducible-factor-1-alpha
#8
JOURNAL ARTICLE
Niya L Morris, David N Michael, Kathryn M Crotty, Sarah S Chang, Samantha M Yeligar
Excessive alcohol use increases the risk of developing respiratory infections partially due to impaired alveolar macrophage (AM) phagocytic capacity. Previously, we showed that chronic ethanol (EtOH) exposure led to mitochondrial derangements and diminished oxidative phosphorylation in AM. Since oxidative phosphorylation is needed to meet the energy demands of phagocytosis, EtOH mediated decreases in oxidative phosphorylation likely contribute to impaired AM phagocytosis. Treatment with the peroxisome proliferator-activated receptor gamma (PPARγ) ligand, pioglitazone (PIO), improved EtOH-mediated decreases in oxidative phosphorylation...
2022: Frontiers in Immunology
https://read.qxmd.com/read/34669714/beneficial-effects-of-a-plant-fish-oil-slow-carbohydrate-diet-on-cardio-metabolic-health-exceed-the-correcting-effects-of-metformin-pioglitazone-in-diabetic-pigs-fed-a-fast-food-diet
#9
JOURNAL ARTICLE
Sietse J Koopmans, Heleen M M van Beusekom, F Josef van der Staay, Gisabeth Binnendijk, Marcel Hulst, Zlaw Mroz, Mariette T Ackermans, Lambertus Benthem
BACKGROUND: Lifestyle influences endocrine, metabolic and cardiovascular homeostasis. This study investigated the impact of diet and oral anti-diabetic medication on cardio-metabolic health in human-sized diabetic pigs. METHODS: After a growing pre-phase from ~30 to ~69 kg during which domestic pigs were fed either a low fat, low sucrose diet (group A) or a fast food-type diet elevated in lard (15%) and sucrose (40%) (group B), the pigs were subdivided in 5 groups (n = 7-8 pigs per group)...
2021: PloS One
https://read.qxmd.com/read/34328855/synthesis-of-a-novel-glibenclamide-pioglitazone-hybrid-compound-and-its-effects-on-glucose-homeostasis-in-normal-and-insulin-resistant-rats
#10
JOURNAL ARTICLE
Camila Pires Mendes, Bárbara Graziela Postal, Marisa Jádna Silva Frederico, Rui Gonçalves Marques Elias, Veronica Aiceles de Medeiros Pinto, Cristiane da Fonte Ramos, Patrícia Devantier Neuenfeldt, Ricardo José Nunes, Fátima Regina Mena Barreto Silva
A new library of hybrid compounds that combine the functional parts of glibenclamide and pioglitazone was designed and developed. Compounds were screened for their antihyperglycemic effects on the glucose tolerance curve. This approach provided a single molecule that optimizes the pharmacological activities of two drugs used for the treatment of diabetes mellitus type 2 (DM2) and that have distinct biological activities, potentially minimizing the adverse effects of the original drugs. From a total of 15 compounds, 7 were evaluated in vivo; the compound 2; 4- [2- (2-phenyl-4-oxo-1,3-thiazolidin-3-yl) ethyl] benzene-1-sulfonamide (PTEBS) was selected to study its mechanism of action on glucose and lipid homeostasis in acute and chronic animal models related to DM2...
September 2021: Bioorganic Chemistry
https://read.qxmd.com/read/33864097/neuroprotective-and-antioxidative-effects-of-pioglitazone-in-brain-tissue-adjacent-to-the-ischemic-core-are-mediated-by-pi3k-akt-and-nrf2-are-pathways
#11
JOURNAL ARTICLE
Yi Zhao, Ulf Lützen, Peter Gohlke, Ping Jiang, Thomas Herdegen, Juraj Culman
The present study elucidates the neuroprotective mechanisms of the PPARγ (peroxisome proliferator-activated receptor γ) agonist pioglitazone in survival of ischemic neurons following middle cerebral artery occlusion with reperfusion (MCAO). Intracerebroventricular infusion of pioglitazone over 5 days before and 24 or 48 h after MCAO alleviated neurological impairments, inhibited apoptosis 24 h, and activated the PI3K/Akt pathway along with increased phosphorylation of Akt (ser473) and GSK-3β (ser9) in the peri-infarct cortical areas 48 h after MCAO...
August 2021: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/33834866/periostin-promotes-arterial-calcification-through-ppar%C3%AE-related-glucose-metabolism-reprogramming
#12
JOURNAL ARTICLE
Yi Zhu, Jing-Jing Ji, Xiao-Dong Wang, Xue-Jiao Sun, Min Li, Qin Wei, Li-Qun Ren, Nai-Feng Liu
Extracellular matrix (ECM) exerts a series of biological functions and contributes to almost 30% of the osteogenic process. Periostin is a secreted protein that can alter ECM remodeling in response to vascular injury. However, the role of periostin in vascular calcification has yet to be fully investigated. As found in this study, recombinant periostin accelerated the thoracic aortas calcification, increased the expression of glycolysis key enzymes, and disturbed the normal oxidative phosphorylation (OXPHOS) ex vivo, which could be alleviated by the peroxisome proliferation-activated receptor γ (PPARγ) agonist pioglitazone...
June 1, 2021: American Journal of Physiology. Heart and Circulatory Physiology
https://read.qxmd.com/read/33754076/the-role-of-gls1-mediated-glutaminolysis-2-hg-h3k4me3-and-gsh-ros-signals-in-th17-responses-counteracted-by-ppar%C3%AE-agonists
#13
JOURNAL ARTICLE
Yumeng Miao, Yun Zheng, Yanzhi Geng, Ling Yang, Na Cao, Yue Dai, Zhifeng Wei
Background: Peroxisome proliferator-activated receptor gamma (PPARγ) has the ability to counter Th17 responses, but the full mechanisms remain elusive. Herein, we aimed to elucidate this process in view of cellular metabolism, especially glutaminolysis. Methods: MTT, CCK-8, Annexin V-FITC/PI staining or trypan blue exclusion assays were used to analyze cytotoxicity. Flow cytometry and Q-PCR assays were applied to determine Th17 responses. The detection of metabolite levels using commercial kits and rate-limiting enzyme expression using western blotting assays was performed to illustrate the metabolic activity...
2021: Theranostics
https://read.qxmd.com/read/33307106/analysis-of-reproducibility-and-robustness-of-a-human-microfluidic-four-cell-liver-acinus-microphysiology-system-lamps
#14
JOURNAL ARTICLE
Courtney Sakolish, Celeste E Reese, Yu-Syuan Luo, Alan Valdiviezo, Mark E Schurdak, Albert Gough, D Lansing Taylor, Weihsueh A Chiu, Lawrence A Vernetti, Ivan Rusyn
A human microfluidic four-cell liver acinus microphysiology system (LAMPS), was evaluated for reproducibility and robustness as a model for drug pharmacokinetics and toxicology. The model was constructed using primary human hepatocytes or human induced pluripotent stem cell (iPSC)-derived hepatocytes and 3 human cell lines for the endothelial, Kupffer and stellate cells. The model was tested in two laboratories and demonstrated to be reproducible in terms of basal function of hepatocytes, Terfenadine metabolism, and effects of Tolcapone (88 μM), Troglitazone (150 μM), or caffeine (600 μM) over 9 days in culture...
December 8, 2020: Toxicology
https://read.qxmd.com/read/33105536/effect-of-pioglitazone-on-perihematomal-edema-in-intracerebral-hemorrhage-mouse-model-by-regulating-nlrp3-expression-and-energy-metabolism
#15
JOURNAL ARTICLE
Hoon Kim, Jung Eun Lee, Hyun Ju Yoo, Jae Hoon Sung, Seung Ho Yang
Objective: Cerebral edema is the predominant mechanism of secondary inflammation after intracerebral hemorrhage (ICH). Pioglitazone, peroxisome proliferator-activated receptor gamma agonist has been shown to play a role in regulation of central nervous system inflammation. Here, we examined the pharmacological effects of pioglitazone in an ICH mouse model and investigated its regulation on NLRP3 inflammasome and glucose metabolism. Methods: The ICH model was established in C57 BL/6 mice by the stereotactical inoculation of blood (30 µL) into the right frontal lobe...
October 27, 2020: Journal of Korean Neurosurgical Society
https://read.qxmd.com/read/32344313/can-pioglitazone-be-potentially-useful-therapeutically-in-treating-patients-with-covid-19
#16
JOURNAL ARTICLE
Elena Carboni, Anna R Carta, Ezio Carboni
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a pandemic disease (COVID-19) that has spread globally causing more than 30,000 deaths. Despite the immense and ongoing global effort, no efficacious drugs to fight this plague have been identified and patients admitted to the intensive care units (ICU), for respiratory distress, are managed mostly by means of supportive care based on oxygen maintenance. Several authors have reported that the prevalence of hypertension, diabetes, cardiovascular and cerebrovascular diseases comorbidities were indeed frequent among patients with COVID-19, which suggests that these conditions are likely to aggravate and complicate the prognosis...
April 22, 2020: Medical Hypotheses
https://read.qxmd.com/read/30932940/cardiovascular-protective-effect-of-pioglitazone-on-oxidative-stress-in-rats-with-metabolic-syndrome
#17
JOURNAL ARTICLE
Ayca Bilginoglu
BACKGROUND: Although cardiovascular oxidative stress is examined in type 2 diabetes, there is relatively limited number of reports about the effect of pioglitazone, an insulin sensitizer, on cardiovascular oxidative stress in sucrose diet-induced metabolic syndrome (MetS). As a regulator of cardiovascular homeostasis, thioredoxin (TRX) has an important role in defense against oxidative stress in cardiovascular diseases. The purpose of this study is to investigate the role of pioglitazone on oxidative stress markers and TRX1 level in tissues of both heart and aorta from MetS rats...
June 2019: Journal of the Chinese Medical Association: JCMA
https://read.qxmd.com/read/30674874/ppar%C3%AE-and-ppar%C3%AE-activation-attenuates-total-free-fatty-acid-and-triglyceride-accumulation-in-macrophages-via-the-inhibition-of-fatp1-expression
#18
JOURNAL ARTICLE
Guozhu Ye, Han Gao, Zhichao Wang, Yi Lin, Xu Liao, Han Zhang, Yulang Chi, Huimin Zhu, Sijun Dong
Lipid accumulation in macrophages interacts with microenvironment signals and accelerates diabetic atherosclerosis. However, the molecular mechanisms by which macrophage metabolism interacts with microenvironment signals during lipid accumulation are not clearly understood. Accordingly, an untargeted metabolomics approach was employed to characterize the metabolic reprogramming, and to identify potential regulatory targets related to lipid accumulation in macrophages treated with oleate, an important nutrient...
January 15, 2019: Cell Death & Disease
https://read.qxmd.com/read/30668149/pioglitazone-reversed-the-fructose-programmed-astrocytic-glycolysis-and-oxidative-phosphorylation-of-female-rat-offspring
#19
JOURNAL ARTICLE
Chih-Wei Wu, Chun-Ying Hung, Hajime Hirase, You-Lin Tain, Wei-Chia Lee, Julie Y H Chan, Mu-Hui Fu, Lee-Wei Chen, Wen-Chung Liu, Chih-Kuang Liang, Ying-Hao Ho, Yu Chih Kung, Steve Leu, Kay L H Wu
Excessive maternal high-fructose diet (HFD) during pregnancy and lactation has been reported to cause metabolic disorders in the offspring. Whether the infant's brain metabolism is disturbed by maternal HFD is largely unknown. Brain energy metabolism is elevated dramatically during fetal and postnatal development, whereby maternal nutrition is a key factor that determines cellular metabolism. Astrocytes, a nonneuronal cell type in the brain, are considered to support the high-energy demands of neurons by supplying lactate...
April 1, 2019: American Journal of Physiology. Endocrinology and Metabolism
https://read.qxmd.com/read/30597379/comparison-of-the-effects-of-sulforaphane-and-pioglitazone-on-insulin-resistance-and-associated-dyslipidemia-hepatosteatosis-and-endothelial-dysfunction-in-fructose-fed-rats
#20
COMPARATIVE STUDY
Noha M Shawky, George S G Shehatou, Ghada M Suddek, Nariman M Gameil
The purpose of this work was to compare the influences of sulforaphane (SFN) to those of the standard insulin sensitizer pioglitazone (PIO) on high fructose diet (HFrD)-induced insulin resistance, dyslipidemia, hepatosteatosis, and vascular dysfunction in rats. Male Sprague Dawley rats (150-200 g) were fed on a standard diet (control) or a high fructose diet (HFrD, 60% w/w fructose) for 60 days. From day 16, two subgroups of HFrD-fed rats received either SFN (0.5 mg/kg/day, orally) or PIO (5 mg/kg/day, orally) along with HFrD until the end of the experiment...
February 2019: Environmental Toxicology and Pharmacology
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