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https://www.readbyqxmd.com/read/28319690/depression-and-executive-functioning-deficits-predict-poor-occupational-functioning-in-a-large-longitudinal-sample-with-bipolar-disorder
#1
Lisa A O'Donnell, Patricia J Deldin, Andrew Grogan-Kaylor, Melvin G McInnis, Jenna Weintraub, Kelly A Ryan, Joseph A Himle
BACKGROUND: Bipolar Disorder (BD) is characterized by impairments in psychosocial functioning with occupational disability being one of the most significant. Depression and neurocognitive deficits are features of BD most commonly associated with poor occupational functioning (OF). Few studies have examined these features over an extended period of time focusing on distinct aspects of work functioning. METHODS: This longitudinal study included 273 adults with bipolar I disorder (N=173), bipolar II disorder (N=69), and bipolar not otherwise specified (N=31)...
March 16, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28302050/implementation-of-clinical-research-trials-using-web-based-and-mobile-devices-challenges-and-solutions
#2
EDITORIAL
Roy Eagleson, Luis Altamirano-Diaz, Alex McInnis, Eva Welisch, Stefanie De Jesus, Harry Prapavessis, Meghan Rombeek, Jamie A Seabrook, Teresa Park, Kambiz Norozi
BACKGROUND: With the increasing implementation of web-based, mobile health interventions in clinical trials, it is crucial for researchers to address the security and privacy concerns of patient information according to high ethical standards. The full process of meeting these standards is often made more complicated due to the use of internet-based technology and smartphones for treatment, telecommunication, and data collection; however, this process is not well-documented in the literature...
March 17, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/28299558/body-pushing-prescription-drugs-and-hospital-admission
#3
Roger W Byard, Michaela Kenneally
A 39-year-old man died of multi-organ failure complicating mixed drug toxicity that included methadone, oxazepam, oxycodone and nitrazepam. His past medical history involved alcohol and poly-substance abuse with chronic self-harm and suicidal ideation. There had been multiple hospital admissions for drug overdoses. At autopsy the most unusual finding was of two packages of 10 tablets each, wrapped in thin plastic film within the rectum. The insertion of drugs into body orifices and cavities has been termed body pushing to distinguish it from body packing where illicit drugs are wrapped and swallowed for transport and smuggling, and body stuffing where small amounts of loosely wrapped or unwrapped drugs are swallowed to conceal evidence from police...
March 15, 2017: Forensic Science, Medicine, and Pathology
https://www.readbyqxmd.com/read/28299327/minimum-lateral-bone-coverage-required-for-securing-fixation-of-cementless-acetabular-components-in-hip-dysplasia
#4
Masanori Fujii, Yasuharu Nakashima, Tetsuro Nakamura, Yoshihiro Ito, Toshihiko Hara
Objectives. To determine the minimum lateral bone coverage required for securing stable fixation of the porous-coated acetabular components (cups) in hip dysplasia. Methods. In total, 215 primary total hip arthroplasties in 199 patients were reviewed. The average follow-up period was 49 months (range: 24-77 months). The lateral bone coverage of the cups was assessed by determining the cup center-edge (cup-CE) angle and the bone coverage index (BCI) from anteroposterior pelvic radiographs. Further, cup fixation was determined using the modified DeLee and Charnley classification system...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28298802/infantile-cystic-hygroma-an-unusual-perioperative-course
#5
Suman Saini, Madhu Dayal, Amita Gupta
Airway management of an infant with a giant cervical lump may be a difficult task. The anesthesiologist must be prepared to face associated challenges during securing the airway in such patients. We report our experience with One year old infant who presented with huge cystic hygroma in the cervical region leading to recurrent episodes of respiratory tract infection and distress. Surgical removal was needed as sclerotherapy proved ineffective in reducing its size. Proseal laryngeal mask airway was used as a conduit after inhalational induction since airway could not be maintained with bag and mask...
January 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/28298188/enrichment-activities-in-the-medical-school-psychiatry-programme-could-this-be-a-key-to-engaging-medical-students-in-psychiatry-a-study-from-a-high-secure-forensic-psychiatric-uk-hospital
#6
Anna-Marie Mortlock, Ignazio Puzzo, Sophie Taylor, Veena Kumari, Susan Young, Samrat Sengupta, Mrigendra Das
BACKGROUND: The majority of research studies on medical student attitudes toward psychiatry focus on influencing factors and the medical school experience. This study evaluates the effectiveness of a one-day visit to a high secure forensic psychiatric unit on medical students' attitudes towards psychiatry and also assesses career intentions and the factors influencing these. METHOD: Change in attitudes and career intention were measured by administering a questionnaire, which included the 30-item Attitudes Toward Psychiatry (ATP-30) survey, at the start (time 1) and end (time 2) of the one-day visit...
March 16, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28297831/-comparison-of-ablation-of-left-sided-accessory-pathway-by-atrial-septal-and-retrograde-arterial-approach
#7
J G Zhu, Z Y Bao, X Gu
Objective: To compare the advantages and disadvantages of radiofrequency ablation of left-sided accessory pathways by via atrial septal approach with retrograde through aortic approach. Methods: A total of 184 patients of left-side accessory pathways were treated in Taizhou People's Hospital and the Subei People's Hospital from March 2012 to August 2015.A total of 103 cases were treated by aortic retrograde approach as through arterial group, 81 cases were treated by punctured atrial septal to left atrial for mapping and ablation as through atrial septal group...
March 7, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28297811/-analysis-of-short-term-respiratory-adverse-events-in-183-bronchial-thermoplasty-procedures
#8
Y Nong, J T Lin, N Su, X Chen, Q Zhao, C Y Han, R F Qiu
Objective: To analyze the short-term (3 weeks) adverse respiratory events after bronchial thermoplasty(BT) in patients with severe asthma. Methods: The China-Japan Friendship Hospital recruited 62 patients with severe asthma for BT treatment from March 2014 to July 2016, with a total of 183 BT procedures. The data of adverse respiratory events within 3 weeks after procedure were collected to analyze the factors that might potentially influence the occurrence of adverse events. Results: Forty-three patients (69...
March 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28297286/the-dose-penumbra-of-a-custom-made-shield-used-in-hemibody-skin-electron-irradiation
#9
Charlotte I Rivers, Ismail AlDahlawi, Iris Z Wang, Anurag K Singh, Matthew B Podgorsak
We report our technique for hemibody skin electron irradiation with a custom-made plywood shield. The technique is similar to our clinical total skin electron irradiation (TSEI), performed with a six-pair dual field (Stanford technique) at an extended source-to-skin distance (SSD) of 377 cm, with the addition of a plywood shield placed at 50 cm from the patient. The shield is made of three layers of standard 5/8" thick plywood (total thickness of 4.75 cm) that are clamped securely on an adjustable-height stand...
November 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28296370/-use-of-recombinant-human-growth-hormone-rhgh
#10
Raúl Calzada-León
Recombinant human growth hormone, synthesized in E.coli or mammalian cells cultures, is since 1985, a useful therapeutic resource to increase growth velocity and final height. In this paper are discussed the four phases (aims, security and efficacy, utility and efficiency) indispensables to define the start of treatment, as well as the absolute, relative and metabolic indications and the transitory and permanent conditions that contraindicate its use. It is commented the way to optimize the results (simple but indispensables indications for the physician, the patients and their family)...
March 2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/28295385/technical-note-the-design-and-function-of-a-horizontal-patient-rotation-system-for-the-purposes-of-fixed-beam-cancer-radiotherapy
#11
Ilana Feain, Lloyd Coleman, Hue Wallis, Richard Sokolov, Ricky O'Brien, Paul Keall
PURPOSE: Cancer radiation therapy treatment is performed by delivering a 3D dose distribution to the tumour via the relative rotation between beam and patient. Whilst most modern machines rotate the radiation beam around a still patient, the treatment can also be delivered by rotating the patient relative to a fixed beam. Fixed-beam, patient rotation radiotherapy machines show promise for reducing the size, surface area footprint, and shielding requirements compared with rotating gantry machines...
March 15, 2017: Medical Physics
https://www.readbyqxmd.com/read/28294038/medic-bleep
#12
(no author information available yet)
Medic Bleep is a secure instant messaging app that enables clinicians to discuss patient care quickly, securely and legally. It looks and feels like WhatsApp, but has been designed for the healthcare market to enable staff to communicate with each other, and to help speed up conversations between clinicians to increase efficiency.
March 15, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28292295/prospective-clinical-evaluation-of-a-novel-anatomic-cuff-for-forearm-crutches-in-patients-with-osteoarthritis
#13
Thomas Hügle, Ansgar Arnieri, Margerita Bünter, Stefan Schären, Annegret Mündermann
BACKGROUND: The use of forearm crutches has been associated with pain and neuropraxia along the ulnar bone. Whilst anatomic grips have improved comfort of crutch walking, to date anatomic forearm cuffs have not been clinically evaluated. The aim of this clinical pilot study was to determine if the use of forearm crutches with anatomic cuffs reduces pain and increases comfort and function in long-term users of forearm crutches during a 4-week period. METHOD: Prospective study in ten patients suffering from end-stage osteoarthritis of the lower extremity...
March 14, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28290955/dynamic-insights-on-surgical-activity-in-a-new-modern-warfare-the-french-role-2-in-bangui-central-african-republic
#14
Olivier Barbier, Pierre Pasquier, Maelle Racle, Yoann Baudoin, Brice Malgras
INTRODUCTION: In December 2013, France deployed more than 2,000 soldiers in Central African Republic with two main missions, to restore security and to improve the humanitarian situation. The objectives of this article were to analyze the surgical activity of forward surgical teams in Central African Republic over 2 years and to discuss features of training for deployed surgeons. MATERIALS AND METHODS: From December 5, 2013, to September 30, 2015, we retrospectively reviewed the electronic surgical database...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28290813/-causes-of-angina-pectoris-in-survivors-of-myocardial-infarction-and-the-role-of-optimization-of-antianginal-therapy-data-of-the-linkor-study-e
#15
M G Glezer, E I Astashkin On Behalf Of The Linkor Study Investigators
AIM: to analyze causes of attacks of angina pectoris and assess impact of optimization of antianginal therapy on frequency of attacks provoked by various factors. MATERIAL AND METHOD: We analyzed diaries of 1226 survivors of myocardial infarction (MI) which occurred within 12months before inclusion in the LINKOR program. Causes of pain and their changes with correction of antianginal therapy were registered during 16 weeks of follow-up. RESULTS: Participants of the study indicated the following factors as causes of pain: physical exertion (74...
December 2016: Kardiologiia
https://www.readbyqxmd.com/read/28290243/motif-discovery-in-speech-application-to-monitoring-alzheimer-s-disease
#16
Peter Garrard, Vanda Nemes, Dragana Nikolic, Anna Barney
BACKGROUND: Perseveration - repetition of words, phrases or questions in speech - is commonly described in Alzheimer's disease (AD). Measuring perseveration is difficult, but may index cognitive performance, aiding diagnosis and disease monitoring. Continuous recording of speech would produce a large quantity of data requiring painstaking manual analysis, and risk violating patients' and others' privacy. A secure record and an automated approach to analysis are required. OBJECTIVES: To record bone-conducted acoustic energy fluctuations from a subject's vocal apparatus using an accelerometer, to describe the recording and analysis stages in detail, and demonstrate that the approach is feasible in AD...
March 9, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28289034/the-impact-of-mucositis-on-absorption-and-systemic-drug-exposure-of-isavuconazole
#17
Laura L Kovanda, Francisco M Marty, Johan Maertens, Amit V Desai, Christopher Lademacher, Marc Engelhardt, Qiaoyang Lu, William W Hope
Isavuconazonium sulfate is the water-soluble prodrug of isavuconazole. Population analyses have demonstrated relatively predictable pharmacokinetic (PK) behavior in diverse patient populations. We evaluated the impact of mucositis on the oral isavuconazole exposure using population PK modeling. METHODS: We evaluated patients treated in two phase 3 trials of isavuconazole, SECURE for treatment of invasive aspergillosis (IA) and other filamentous fungi and VITAL for patients with mucormycosis, invasive fungal disease (IFD) caused by other rare fungi, or IA and renal impairment...
March 13, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28288578/case-report-of-pierre-robin-sequence-with-severe-upper-airway-obstruction-who-was-rescued-by-fiberoptic-nasotracheal-intubation
#18
Satoru Takeshita, Hiroko Ueda, Tatenobu Goto, Daisuke Muto, Hiroki Kakita, Kazuo Oshima, Takahisa Tainaka, Takayuki Ono, Yoshiaki Kazaoka, Yasumasa Yamada
BACKGROUND: Pierre Robin sequence (PRS) refers to the association of micrognathia, glossoptosis, and airway obstruction. Cases with severe dyspnea due to upper airway obstruction immediately after birth are very rare. We here report two cases with PRS who developed severe dyspnea due to morphological abnormality immediately after birth and were rescued by fiberoptic nasotracheal intubation. CASE PRESENTATION: The patient in case 1 had micrognathia and cleft palate, and his tongue protruded into the nasal cavity via a cleft palate...
March 14, 2017: BMC Anesthesiology
https://www.readbyqxmd.com/read/28288104/the-asthma-mobile-health-study-a-large-scale-clinical-observational-study-using-researchkit
#19
Yu-Feng Yvonne Chan, Pei Wang, Linda Rogers, Nicole Tignor, Micol Zweig, Steven G Hershman, Nicholas Genes, Erick R Scott, Eric Krock, Marcus Badgeley, Ron Edgar, Samantha Violante, Rosalind Wright, Charles A Powell, Joel T Dudley, Eric E Schadt
The feasibility of using mobile health applications to conduct observational clinical studies requires rigorous validation. Here, we report initial findings from the Asthma Mobile Health Study, a research study, including recruitment, consent, and enrollment, conducted entirely remotely by smartphone. We achieved secure bidirectional data flow between investigators and 7,593 participants from across the United States, including many with severe asthma. Our platform enabled prospective collection of longitudinal, multidimensional data (e...
March 13, 2017: Nature Biotechnology
https://www.readbyqxmd.com/read/28286761/developing-an-app-by-exploiting-web-based-mobile-technology-to-inspect-controlled-substances-in-patient-care-units
#20
Ying-Hao Lu, Li-Yao Lee, Ying-Lan Chen, Hsing-I Cheng, Wen-Tsung Tsai, Chen-Chun Kuo, Chung-Yu Chen, Yaw-Bin Huang
We selected iOS in this study as the App operation system, Objective-C as the programming language, and Oracle as the database to develop an App to inspect controlled substances in patient care units. Using a web-enabled smartphone, pharmacist inspection can be performed on site and the inspection result can be directly recorded into HIS through the Internet, so human error of data translation can be minimized and the work efficiency and data processing can be improved. This system not only is fast and convenient compared to the conventional paperwork, but also provides data security and accuracy...
2017: BioMed Research International
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