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JOURNAL ARTICLE
Lisanne Boekhoud, Helena M E A Schaap, Rick L Huizinga, Tycho J Olgers, Jan C Ter Maaten, Douwe F Postma, Hjalmar R Bouma
PURPOSE: Sepsis has a high incidence and a poor prognosis. Early recognition is important to facilitate timely initiation of adequate care. Sepsis screening tools, such as the (quick) Sequential Organ Failure Assessment ((q)SOFA) and National Early Warning Score (NEWS), could help recognize sepsis. These tools have been validated in a general immunocompetent population, while their performance in immunocompromised patients, who are particularly at risk of sepsis development, remains unknown...
April 12, 2024: Infection
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JOURNAL ARTICLE
Xiao-Ming Lin, Lian-Fang Zhang, Yu-Ting Wang, Ting Huang, Xue-Feng Lin, Xiang-Yu Hong, Hong-Jun Zheng, Rong-Cheng Xie, Jie-Fei Ma
BACKGROUND: Sepsis is a life-threatening condition characterized by an aberrant host response to infection, resulting in multi-organ dysfunction. The application of currently available prognostic indicators for sepsis in primary hospitals is challenging. In this retrospective study, we established a novel index, the neutrophil-to-lymphocyte-to-monocyte ratio (NLMR), based on routine blood examination upon admission, and assessed its prognostic value for early mortality risk in adult patients with septic shock...
April 15, 2024: Heliyon
#3
JOURNAL ARTICLE
Sunaina T Karna, Zainab Ahmad, Pooja Thaware, Saurabh Trivedi, Revadi Gouroumourty, Pooja Singh, Vaishali Waindeskar, Jai Prakash Sharma, Ashutosh Kaushal, Saurabh Saigal
Purpose There is limited data from the Indian subcontinent regarding the surgical outcomes of coronavirus disease (COVID-19) patients. In this observational study, we aimed to evaluate the postoperative outcomes after emergency surgery in COVID-19 patients compared to concurrent age and gender-matched controls. We also sought to analyze the possible predictors of postoperative mortality in COVID-19 patients. Methods This matched cohort study was conducted in a tertiary care teaching hospital in central India, between 1st July 2021 and 30th June 2022...
March 2024: Curēus
#4
JOURNAL ARTICLE
Sarah K S Knack, Nathaniel Scott, Brian E Driver, Matthew E Prekker, Lauren Page Black, Charlotte Hopson, Ellen Maruggi, Olivia Kaus, Walker Tordsen, Michael A Puskarich
STUDY OBJECTIVE: Compare physician gestalt to existing screening tools for identifying sepsis in the initial minutes of presentation when time-sensitive treatments must be initiated. METHODS: This prospective observational study conducted with consecutive encounter sampling took place in the emergency department (ED) of an academic, urban, safety net hospital between September 2020 and May 2022. The study population included ED patients who were critically ill, excluding traumas, transfers, and self-evident diagnoses...
March 25, 2024: Annals of Emergency Medicine
#5
JOURNAL ARTICLE
Lucile Dhuiege, Daniel De Backer, Simon Kalisz, Frédéric Cavallotto, Céline Rousseaux, Chloé Van Overstraeten, Pauline Lambert
INTRODUCTION: The seasonal flu is a very important reason for consultation every winter. Symptoms can quickly progress to severe pneumonia. Currently, few tools exist to assess the clinical severity of patients. The aim of this study is to demonstrate the role of lung ultrasound as a marker of severity in patients with influenza. METHODS: 79 patients who arrived at the emergency department with flu-like symptoms were included. A pulmonary ultrasound looking for an interstitial syndrome or consolidation was performed...
March 2024: Revue Médicale de Liège
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JOURNAL ARTICLE
Gianni Turcato, Arian Zaboli, Serena Sibilio, Francesco Brigo
BACKGROUND: Infectious states are subtle and rapidly evolving conditions observed daily in the emergency department (ED), and their prognostic evaluation remains a complex clinical challenge. Recently, estimated plasma volume status (ePVS) has been suggested to have a prognostic role in conditions where volemic alteration is central to the pathophysiology. The aim of this study was to verify whether ePVS recorded at ED admission can provide prognostic indications of 30-day mortality in patients with infection...
February 12, 2024: American Journal of the Medical Sciences
#7
RANDOMIZED CONTROLLED TRIAL
Maria Evangelia Adami, Antigone Kotsaki, Nikolaos Antonakos, Efthymia Giannitsioti, Stamatios Chalvatzis, Maria Saridaki, Christina Avgoustou, Karolina Akinosoglou, Konstantina Dakou, Georgia Damoraki, Konstantina Katrini, Panagiotis Koufargyris, Vasileios Lekakis, Antonia Panagaki, Asimina Safarika, Jesper Eugen-Olsen, Evangelos J Giamarellos-Bourboulis
BACKGROUND: Sepsis guidelines suggest immediate start of resuscitation for patients with quick Sequential Organ Failure Assessment (qSOFA) 2 or 3. However, the interpretation of qSOFA 1 remains controversial. We investigated whether measurements of soluble urokinase plasminogen activator receptor (suPAR) may improve risk detection when qSOFA is 1. METHODS: The study had two parts. At the first part, the combination of suPAR with qSOFA was analyzed in a prospective cohort for early risk detection...
February 6, 2024: Critical Care: the Official Journal of the Critical Care Forum
#8
JOURNAL ARTICLE
Li Wang, Xin Cai, Shi Peng, Dongling Tang, Pingan Zhang
BACKGROUND: Sepsis is a common disease in the intensive care unit (ICU). In recent years, the incidence rate and mortality rate remain high. Early diagnosis of sepsis is crucial for treatment and can effectively reduce mortality. So far, the ability of serum peptidylarginine deaminase 2 (PAD2) in the diagnosis and prognosis of sepsis patients is still unclear. We conducted this study to reveal the clinical value of PAD2 as a biomarker for sepsis patients. METHODS: A prospective study method was used to select 207 patients in the ICU of Renmin Hospital of Wuhan University from May 2022 to May 2023...
January 26, 2024: Clinica Chimica Acta; International Journal of Clinical Chemistry
#9
JOURNAL ARTICLE
Joachim Doua, Jesús Rodríguez-Baño, Rachel Froget, Padma Puranam, Oscar Go, Jeroen Geurtsen, Sanne van Rooij, Tuba Vilken, Inage Minoru, Izumi Yasumori, Bart Spiessens, Evelina Tacconelli, Lena M Biehl, Joshua T Thaden, Michal Sarnecki, Herman Goossens, Jan Poolman, Marc Bonten, Miquel Ekkelenkamp
BACKGROUND: Clinical data characterizing invasive Escherichia coli disease (IED) are limited. We assessed the clinical presentation of IED and antimicrobial resistance (AMR) patterns of causative E. coli isolates in older adults. METHODS: EXPECT-2 (NCT04117113) was a prospective, observational, multinational, hospital-based study conducted in patients with IED aged ≥ 60 years. IED was determined by the microbiological confirmation of E...
January 25, 2024: Infection
#10
JOURNAL ARTICLE
Andrew Li, Lowell Ling, Hanyu Qin, Yaseen M Arabi, Sheila Nainan Myatra, Moritoki Egi, Je Hyeong Kim, Mohd Basri Mat Nor, Do Ngoc Son, Wen-Feng Fang, Bambang Wahyuprajitno, Madiha Hashmi, Mohammad Omar Faruq, Boonsong Patjanasoontorn, Maher Jaffer Al Bahrani, Babu Raja Shrestha, Ujma Shrestha, Khalid Mahmood Khan Nafees, Kyi Kyi Sann, Jose Emmanuel M Palo, Naranpurev Mendsaikhan, Aidos Konkayev, Khamsay Detleuxay, Yiong Huak Chan, Bin Du, Jigeeshu Vasishtha Divatia, Younsuck Koh, Jason Phua
BACKGROUND: There is conflicting evidence on association between quick sequential organ failure assessment (qSOFA) and sepsis mortality in ICU patients. The primary aim of this study was to determine the association between qSOFA and 28-day mortality in ICU patients admitted for sepsis. Association of qSOFA with early (3-day), medium (28-day), late (90-day) mortality was assessed in low and lower middle income (LLMIC), upper middle income (UMIC) and high income (HIC) countries/regions...
January 23, 2024: Critical Care: the Official Journal of the Critical Care Forum
#11
JOURNAL ARTICLE
Abdullah M Algarni, Musa S Alfaifi, Ali A Al Bshabshe, Othman M Omair, Mohammed A Alsultan, Hasan M Alzahrani, Hadi E Alali, Abdullah A Alsabaani, Ali M Alqarni, Salah A Alghanem, Bandar S Al Mufareh, Ayesha M Almemari, Abdulrahman A Sindi, Ibrahim U Ozturan, Abdullah A Alhadhira, Asaad S Shujaa, Abdullah H Alotaibi, Moosa M Awladthani, Ahmed A Alsaad, Abdullah A Almarshed, AlHanouv M AlQahtani, Tim R Harris, Bader A Alyahya, Saad A Assiri, Feras H Abuzeyad, Sara N Kazim, Abdulrahman A Al-Fares, Faisal Y Almazroua, Naif T Marzook, Abdullah A Basri, Abdallah M Elsafti, Abdulaziz S Alalshaikh, Cansu A Özturan, Yousef I Alawad, Awad AlOmari, Malek A Alkhateeb, Moonis M Farooq, Latifa Ali AlMutairi, Muneera M Alasfour, Mohammad I Al Haber, Umma-Kulthum A Umar, Nidal H Bokhary, Saeed F Alqahtani, Abdulrhman Almutairi, Hisham F Alyahya, Wejdan S Alzahrani, Fawziah Alsalmi, Abdulmajeed M Omair, Faysal M Alasmari, Sultan Y Alfifi, Mohammed S Al-Nujimi, Farid Foroutan
BACKGROUND: Early identification of a patient with infection who may develop sepsis is of utmost importance. Unfortunately, this remains elusive because no single clinical measure or test can reflect complex pathophysiological changes in patients with sepsis. However, multiple clinical and laboratory parameters indicate impending sepsis and organ dysfunction. Screening tools using these parameters can help identify the condition, such as SIRS, quick SOFA (qSOFA), National Early Warning Score (NEWS), or Modified Early Warning Score (MEWS)...
2024: PloS One
#12
JOURNAL ARTICLE
Abhishek Kumar, Ashok Kumar Pannu, Mohan Kumar, Archana Angrup, Pinaki Dutta, Navneet Sharma
Background: An early prediction of infection is challenging in diabetic ketoacidosis (DKA). Methods: This prospective cohort study aimed to assess effectiveness of various sepsis screening tools in predicting infections and prognosis in DKA. Results: Among 141 cases, infection (44.0%) was the commonest precipitating factor. A Sequential Organ Failure Assessment score ≥4 showed high specificity (82.28%) and high positive likelihood ratio (2.64) but limited sensitivity (46.77%). Conversely, Systemic Inflammatory Response Syndrome ≥2 exhibited good sensitivity (95...
November 2023: Biomarkers in Medicine
#13
MULTICENTER STUDY
Kyung Hun Yoo, Sung-Hyuk Choi, Gil Joon Suh, Sung Phil Chung, Han Sung Choi, Yoo Seok Park, You Hwan Jo, Tae Gun Shin, Tae Ho Lim, Won Young Kim, Juncheol Lee
PURPOSE: Early identification of sepsis with a poor prognosis in the emergency department (ED) is crucial for prompt management and improved outcomes. This study aimed to examine the predictive value of sequential organ failure assessment (SOFA), quick SOFA (qSOFA), lactate to albumin ratio (LAR), C-reactive protein to albumin ratio (CAR), and procalcitonin to albumin ratio (PAR), obtained in the ED, as predictors for 28-day mortality in patients with sepsis and septic shock. MATERIALS AND METHODS: We included 3499 patients (aged ≥19 years) from multicenter registry of the Korean Shock Society between October 2015 and December 2019...
April 2024: American Journal of Emergency Medicine
#14
JOURNAL ARTICLE
Anand Kulkarni, Kalyan Rakam, Mahathi Avadhanam, Yogita V P, Chinmayee Rachakonda, Anveshi Satyavadi, Asim A Zuberi, Santhosh Reddy, Sowmya Iyengar, Anand Gupta, Mithun Sharma, Nagaraja R Padaki, Reddy Rajender, Nageshwar Reddy Duvvur
BACKGROUND: Patients with cirrhosis are susceptible to infections, especially by multidrug-resistant organisms (MDROs). There are limited data on the incidence of culture-positive infections and the validity of Sepsis 3-criteria in patients with cirrhosis admitted to the intensive care unit (ICU) in India, which we aimed to assess. METHODS: In this prospective study, we included consecutive patients with cirrhosis admitted to the ICU between November 1, 2021, and April 30, 2022...
October 2023: Curēus
#15
JOURNAL ARTICLE
Taehwa Kim, Yunwon Tae, Hye Ju Yeo, Jin Ho Jang, Kyungjae Cho, Dongjoon Yoo, Yeha Lee, Sung-Ho Ahn, Younga Kim, Narae Lee, Woo Hyun Cho
BACKGROUND: Successful sepsis treatment depends on early diagnosis. We aimed to develop and validate a system to predict sepsis and septic shock in real time using deep learning. METHODS: Clinical data were retrospectively collected from electronic medical records (EMRs). Data from 2010 to 2019 were used as development data, and data from 2020 to 2021 were used as validation data. The collected EMRs consisted of eight vital signs, 13 laboratory data points, and three demographic information items...
November 17, 2023: Journal of Clinical Medicine
#16
JOURNAL ARTICLE
Alireza Nikzad Jamnani, Afshin Gholipour Baradari, Saeed Kargar-Soleimanabad, Sepehr Javaheri
INTRODUCTION: Patients diagnosed with Coronavirus disease 2019 exhibit varied clinical outcomes, with a reported mortality rate exceeding 30% in those requiring admission to the ICU. The objective of this study was to assess the predictive capacity of Sequential Organ Failure Assessment (SOFA) and quick Sequential Organ Failure Assessment (qSOFA) scores in determining mortality risk among severe COVID-19 patients. METHOD AND MATERIALS: This retrospective study was performed by analyzing the data of patients with COVID-19 who were hospitalized in the ICUs...
November 2023: Annals of Medicine and Surgery
#17
JOURNAL ARTICLE
Xiaoqin Su, Hongyan Zhang, Wenjun Yuan, Meng Yi, Chenghao Fu, Jiawei Jiang, Hongmei Gao
OBJECTIVE: To explore the predictive value of acute physiology and chronic health evaluation II (APACHE II), sequential organ failure assessment (SOFA), quick sequential organ failure assessment (qSOFA) and modified early warning score (MEWS) in evaluating the prognosis of patients in intensive care unit (ICU) of secondary hospitals, and to provide guidance for clinical application. METHODS: The clinical data of adult critical patients admitted to the ICU of Wanzhou District First People's Hospital from October 2022 to April 2023 were retrospectively analyzed...
October 2023: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
#18
JOURNAL ARTICLE
Changya Liu, Xinxin Wu, Rou Deng, Xiangru Xu, Caiyu Chen, Linguangjin Wu, Wen Zhang, Hongqiang Yang, Yuerong Fei, Yuting Sun, Shuang Zhou, Bangjiang Fang
OBJECTIVE: To evaluate the prognostic ability of systemic immune-inflammation index (SII) combine with quick Sequential Organ Failure Assessment (qSOFA) criteria in predicting the 28-day mortality of sepsis. METHODS: A retrospective cohort study was conducted, with the population comprised in whom sepsis was confirmed. Clinical and laboratory data recorded were analyzed. The score of Sequential Organ Failure Assessment (SOFA), SII, qSOFA were calculated. Multivariable regression, receiver operating characteristic (ROC) analysis and Kaplan-Meier method were used to identify and compared the predictors of prognosis among SOFA, qSOFA, and the combination of SII with qSOFA...
September 2023: Heliyon
#19
JOURNAL ARTICLE
Yi-Chin Chu, Yi Liu, Shih-Feng Weng, Chao-Wen Chen
BACKGROUND: The mortality rate for sepsis and septic shock in surgical patients is approximately 36%, which is higher than that of other medical patients. Predisposition, infection/injury, response, and organ dysfunction (PIRO) is currently the most widely used tool for assessing patients with surgical sepsis. However, it is not a standardized assessment tool for surgical patients in general. PURPOSE: The purposes of this study were to (a) create a modified PIRO (mPIRO) that adds a count of platelets and does not include a body temperature reading; (b) test the sensitivity and specificity of the mPIRO for predicting mortality and adverse events among patients with surgical sepsis; and (c) compare the predictive accuracy of the mPIRO, sequential organ failure assessment (SOFA), quick SOFA, and PIRO tools...
September 12, 2023: Journal of Nursing Research: JNR
#20
RANDOMIZED CONTROLLED TRIAL
Fei Liu, Jie Yao, Chunyan Liu, Songtao Shou
BACKGROUND: This study aimed to construct predictive models for the risk of sepsis in patients with Acute pancreatitis (AP) using machine learning methods and compared optimal one with the logistic regression (LR) model and scoring systems. METHODS: In this retrospective cohort study, data were collected from the Medical Information Mart for Intensive Care III (MIMIC III) database between 2001 and 2012 and the MIMIC IV database between 2008 and 2019. Patients were randomly divided into training and test sets (8:2)...
September 1, 2023: BMC Surgery
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