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Lactate AND PPAR gamma

Alexandre Vallée, Yves Lecarpentier, Rémy Guillevin, Jean-Noël Vallée
Entropy production rate is increased by several metabolic and thermodynamics abnormalities in neurodegenerative diseases (NDs). Irreversible processes are quantified by changes in the entropy production rate. This review is focused on the opposing interactions observed in NDs between the canonical WNT/beta-catenin pathway and PPAR gamma and their metabolic and thermodynamic implications. In amyotrophic lateral sclerosis and Huntington's disease, WNT/beta-catenin pathway is upregulated, whereas PPAR gamma is downregulated...
March 23, 2018: Neuromolecular Medicine
Alexandre Vallée, Yves Lecarpentier, Rémy Guillevin, Jean-Noël Vallée
Gliomas cells are the site of numerous metabolic and thermodynamics abnormalities with an increasing entropy rate which is characteristic of irreversible processes driven by changes in Gibbs energy, heat production, intracellular acidity, membrane potential gradient, and ionic conductance. We focus our review on the opposing interactions observed in glioma between the canonical WNT/beta-catenin pathway and PPAR gamma and their metabolic and thermodynamic implications. In gliomas, WNT/beta-catenin pathway is upregulated while PPAR gamma is downregulated...
2017: Frontiers in Physiology
Yves Lecarpentier, Victor Claes, Alexandre Vallée, Jean-Louis Hébert
Cancer cells are the site of numerous metabolic and thermodynamic abnormalities. We focus this review on the interactions between the canonical WNT/beta-catenin pathway and peroxisome proliferator-activated receptor gamma (PPAR gamma) in cancers and their implications from an energetic and metabolic point of view. In numerous tissues, PPAR gamma activation induces inhibition of beta-catenin pathway, while the activation of the canonical WNT/beta-catenin pathway inactivates PPAR gamma. In most cancers but not all, PPAR gamma is downregulated while the WNT/beta-catenin pathway is upregulated...
December 2017: Clinical and Translational Medicine
Yves Lecarpentier, Victor Claes, Alexandre Vallée, Jean-Louis Hébert
In both colon cancer and type 2 diabetes, metabolic changes induced by upregulation of the Wnt/beta-catenin signaling and downregulation of peroxisome proliferator-activated receptor gamma (PPAR gamma) may help account for the frequent association of these two diseases. In both diseases, PPAR gamma is downregulated while the canonical Wnt/beta-catenin pathway is upregulated. In colon cancer, upregulation of the canonical Wnt system induces activation of pyruvate dehydrogenase kinase and deactivation of the pyruvate dehydrogenase complex...
2017: PPAR Research
Ola Ahmed El-Gohary, Mona Maher Allam
Infarct-like lesion induced by isoprenaline is a well-known model to study myocardial infarction (MI). Vitamin D has been shown to have anti-inflammatory and antioxidant effects. Recent studies highlighted cross talk between vitamin D and peroxisome proliferator-activated receptor gamma (PPAR-γ). The present study was designed to investigate the effect of pretreatment with vitamin D on the isoprenaline-induced infarct-like lesion in rats and the role of PPAR-γ as a novel mechanism in vitamin-D-mediated cardioprotective effect...
June 2017: Canadian Journal of Physiology and Pharmacology
Hanna Bayer, Kerstin Lang, Eva Buck, Julia Higelin, Lara Barteczko, Noemi Pasquarelli, Jasmin Sprissler, Tanja Lucas, Karlheinz Holzmann, Maria Demestre, Katrin S Lindenberg, Karin M Danzer, Tobias Boeckers, Albert C Ludolph, Luc Dupuis, Patrick Weydt, Anke Witting
BACKGROUND: Monogenetic forms of amyotrophic lateral sclerosis (ALS) offer an opportunity for unraveling the molecular mechanisms underlying this devastating neurodegenerative disorder. In order to identify a link between ALS-related metabolic changes and neurodegeneration, we investigated whether ALS-causing mutations interfere with the peripheral and brain-specific expression and signaling of the metabolic master regulator PGC (PPAR gamma coactivator)-1α (PGC-1α). METHODS: We analyzed the expression of PGC-1α isoforms and target genes in two mouse models of familial ALS and validated the stimulated PGC-1α signaling in primary adipocytes and neurons of these animal models and in iPS derived motoneurons of two ALS patients harboring two different frame-shift FUS/TLS mutations...
January 2017: Neurobiology of Disease
Seung-Hwan Moon, Su Jin Lee, Kyung-Ho Jung, Cung Hoa Thien Quach, Jin-Won Park, Jin Hee Lee, Young Seok Cho, Kyung-Han Lee
UNLABELLED: We evaluated how troglitazone influences cancer cell glucose metabolism and uptake of (18)F-FDG, and we investigated its molecular mechanism and relation to the drug's anticancer effect. METHODS: Human T47D breast and HCT116 colon cancer cells that had been treated with troglitazone were measured for (18)F-FDG uptake, lactate release, oxygen consumption rate, mitochondrial membrane potential, and intracellular reactive oxygen species. Viable cell content was measured by sulforhodamine-B assays...
January 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Soundharrajan Ilavenil, Da Hye Kim, Mariadhas Valan Arasu, Srisesharam Srigopalram, Ravikumar Sivanesan, Ki Choon Choi
Synthetic drugs are commonly used to cure various human ailments at present. However, the uses of synthetic drugs are strictly regulated because of their adverse effects. Thus, naturally occurring molecules may be more suitable for curing disease without unfavorable effects. Therefore, we investigated phenyllactic acid (PLA) from Lactobacillus plantarum with respect to its effects on adipogenic genes and their protein expression in 3T3-L1 pre-adipocytes by qPCR and western blot techniques. PLA enhanced differentiation and lipid accumulation in 3T3-L1 cells at the concentrations of 25, 50, and 100 μM...
August 24, 2015: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Jaroslav Zelenka, Aleš Dvořák, Lukáš Alán
A moderate elevation of reactive oxygen species (ROS) production and a mild inhibition of mitochondrial respiratory chain have been associated with a health promotion and a lifespan extension in several animal models of aging. Here, we tested whether this phenomenon called mitohormesis could be mediated by L-lactate. The treatment with 5 mM L-lactate significantly increased H2O2 production and slightly inhibited the respiration in cultured skin fibroblasts and in isolated mitochondria. The L-lactate exposure was associated with oxidation of intracellular glutathione, phosphorylation of 5'AMP-activated protein kinase (AMPK), and induction of peroxisome proliferator-activated receptor gamma coactivator 1α (PGC1α) transcription...
2015: Oxidative Medicine and Cellular Longevity
Grégory Pourié, Nicolas Martin, Carine Bossenmeyer-Pourié, Nassila Akchiche, Rosa Maria Guéant-Rodriguez, Andréa Geoffroy, Elise Jeannesson, Sarah El Hajj Chehadeh, Khalid Mimoun, Patrick Brachet, Violette Koziel, Jean-Marc Alberto, Deborah Helle, Renée Debard, Brigitte Leininger, Jean-Luc Daval, Jean-Louis Guéant
Deficiency in the methyl donors vitamin B12 and folate during pregnancy and postnatal life impairs proper brain development. We studied the consequences of this combined deficiency on cerebellum plasticity in offspring from rat mothers subjected to deficient diet during gestation and lactation and in rat neuroprogenitor cells expressing cerebellum markers. The major proteomic change in cerebellum of 21-d-old deprived females was a 2.2-fold lower expression of synapsins, which was confirmed in neuroprogenitors cultivated in the deficient condition...
September 2015: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Sílvia Regina de Lima Reis, Naoel Hassan Feres, Leticia Martins Ignacio-Souza, Roberto Vilela Veloso, Vanessa Cristina Arantes, Nair Honda Kawashita, Edson Moleta Colodel, Bárbara Laet Botosso, Marise Auxiliadora de Barros Reis, Márcia Queiroz Latorraca
We evaluated the effects of postweaning nutritional recovery with a soybean flour diet on de novo hepatic lipogenesis and inflammation in adult rats exposed to protein restriction during intrauterine life and lactation. Rats from mothers fed with protein (casein) in a percentage of 17% (control, C) or 6% (low, L) during pregnancy and lactation were fed with diet that contained 17% casein (CC and LC groups, resp.) or soybean (CS and LS groups, resp.) after weaning until 90 days of age. LS and CS rats had low body weight, normal basal serum triglyceride levels, increased ALT concentrations, and high HOMA-IR indices compared with LC and CC rats...
2015: Mediators of Inflammation
D Lifanov, M N Khadyeva, L Sh Rahmatullina, S V Demenev, R R Ibragimov
The aim of this study was to evaluate the effects of short-term creatine supplementation on exercise performance in male athletes depending on the studied genotypes. The present study was limited as long as to two common polymorphisms, such as C34T AMPD1 and Pro12Ala PPARG, selected because previously reported these associations with various aspects of metabolic abnormalities. Athletes had significantly higher frequency of T allele compared to controls AMPD1 34T (7.9 vs. 15.6 %, p < 0.0001) and PPARG 12Ala allele compared to controls (20...
June 2014: Rossiĭskii Fiziologicheskiĭ Zhurnal Imeni I.M. Sechenova
Zheng Jia, Xiao Xinhua, Zhang Qian, Yu Miao, Xu Jianping, Wang Zhixin, Liu Yijing, Li Mingmin
Peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptor proteins that regulate gene transcription. PPARs play essential roles in modulating cell differentiation, development, and metabolism (carbohydrate, lipid, protein). Here, we investigated whether PPARγ plays a role in linking maternal malnutrition and aberrant metabolism in the offspring of mice. After feeding dams with high fat (HF) and low protein (LP) diet during pregnancy and lactation, we examined the effects on the offspring at weaning (age of 3-week)...
January 2015: Yi Chuan, Hereditas
Jiangjiang Zhu, Yuting Sun, Jun Luo, Min Wu, Jianhua Li, Yanhong Cao
Specificity protein 1 (SP1) is a ubiquitous transcription factor that plays an important role in controlling gene expression. Although important in mediating the function of various hormones, the role of SP1 in regulating milk fat formation remains unknown. To investigate the sequence and expression information, as well as its role in modulating lipid metabolism, we cloned SP1 gene from mammary gland of Xinong Saanen dairy goat. The full-length cDNA of the SP1 gene is 4376 bp including 103 bp of 5'UTR, 2358 bp of ORF (HM_236311) and 1915 bp of 3'UTR, which is predicted to encode a 786 amino acids polypeptide...
January 14, 2015: International Journal of Molecular Sciences
Hylde Zirpoli, Mariane Abdillahi, Nosirudeen Quadri, Radha Ananthakrishnan, Lingjie Wang, Rosa Rosario, Zhengbin Zhu, Richard J Deckelbaum, Ravichandran Ramasamy
Dietary n-3 fatty acids (FAs) may reduce cardiovascular disease risk. We questioned whether acute administration of n-3 rich triglyceride (TG) emulsions could preserve cardiac function and decrease injury after ischemia/reperfusion (I/R) insult. We used two different experimental models: in vivo, C57BL/6 mice were exposed to acute occlusion of the left anterior descending coronary artery (LAD), and ex-vivo, C57BL/6 murine hearts were perfused using Langendorff technique (LT). In the LAD model, mice treated with n-3 TG emulsion (1...
2015: PloS One
Priscila P Santos, Fernando Oliveira, Vanessa C M P Ferreira, Bertha F Polegato, Meliza G Roscani, Ana Angelica Fernandes, Pamela Modesto, Bruna P M Rafacho, Silmeia G Zanati, Annarita Di Lorenzo, Luiz S Matsubara, Sergio A R Paiva, Leonardo A M Zornoff, Marcos F Minicucci, Paula S Azevedo
BACKGROUND/AIMS: Experimental and clinical studies have shown the direct toxic effects of cigarette smoke (CS) on the myocardium, independent of vascular effects. However, the underlying mechanisms are not well known. METHODS: Wistar rats were allocated to control (C) and cigarette smoke (CS) groups. CS rats were exposed to cigarette smoke for 2 months. RESULTS: After that morphometric, functional and biochemical parameters were measured. The echocardiographic study showed enlargement of the left atria, increase in the left ventricular systolic volume and reduced systolic function...
2014: PloS One
Eleni Tsiplakou, Emmanouil Flemetakis, Evangelia-Diamanto Kouri, Kyriaki Sotirakoglou, George Zervas
Milk fatty acid (FA) synthesis by the mammary gland involves expression of a large number of genes whose nutritional regulation remains poorly defined. In this study, we examined the effect of long-term under- and over-feeding on the expression of genes (acetyl Co A carboxylase, ACC; fatty acid synthetase, FAS; lipoprotein lipase, LPL; stearoyl Co A desaturase, SCD; peroxisome proliferator activated receptor γ2, PPARγ2; sterol regulatory element binding protein-1, SREBP-1c; and hormone sensitive lipase, HSL) related to FA metabolism in sheep mammary tissue (MT)...
February 2015: Journal of Dairy Research
Yogeeta O Agrawal, Pankaj Kumar Sharma, Birendra Shrivastava, Shreesh Ojha, Harshita M Upadhya, Dharamvir Singh Arya, Sameer N Goyal
The present study investigated the effect of hesperidin, a natural flavonoid, in cardiac ischemia and reperfusion (I/R) injury in diabetic rats. Male Wistar rats with diabetes were divided into five groups and were orally administered saline once daily (IR-sham and IR-control), Hesperidin (100 mg/kg/day; IR-Hesperidin), GW9962 (PPAR-γ receptor antagonist), or combination of both for 14 days. On the 15th day, in the IR-control and IR-treatment groups, rats were subjected to left anterior descending (LAD) coronary artery occlusion for 45 minutes followed by a one-hour reperfusion...
2014: PloS One
Gang Shu, Nai-Sheng Lu, Xiao-Tong Zhu, Yong Xu, Min-Qing Du, Qiu-Ping Xie, Can-Jun Zhu, Qi Xu, Song-Bo Wang, Li-Na Wang, Ping Gao, Qian-Yun Xi, Yong-Liang Zhang, Qing-Yan Jiang
Adipocyte dysfunction is associated with many metabolic diseases such as obesity, insulin resistance and diabetes. Previous studies found that phloretin promotes 3T3-L1 cells differentiation, but the underlying mechanisms for phloretin's effects on adipogenesis remain unclear. In this study, we demonstrated that phloretin enhanced the lipid accumulation in porcine primary adipocytes in a time-dependent manner. Furthermore, phloretin increased the utilization of glucose and nonesterified fatty acid, while it decreased the lactate output...
December 2014: Journal of Nutritional Biochemistry
Jie Wang, Yanjie Bian, Zhuoran Wang, Dan Li, Chunmei Wang, Qingzhang Li, Xuejun Gao
MicroRNAs (miRNAs) are a class of small non-coding, endogenous regulatory RNAs that function by controlling gene expression at the post-transcriptional level. Using small RNA sequencing and qRT-PCR techniques, we found that the expression of miR-152 was significantly increased during lactation in the mammary glands of dairy cows producing high quality milk compared with that in cows producing low quality milk. Furthermore, DNA methyltransferase 1 (DNMT1), which is a target of miR-152, was inversely correlated with the expression levels of miR-152 in the mammary glands of dairy cows...
2014: PloS One
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