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https://www.readbyqxmd.com/read/27930520/is-retrograde-drilling-really-useful-for-osteochondral-lesion-of-talus-with-subchondral-cyst-a-case-report
#1
Seong-Yup Jeong, Jong-Kil Kim, Kwang-Bok Lee
RATIONALE: Retrograde drilling is a well accepted procedure for osteochondral lesion of the talus and subchondral cyst with intact overlying cartilage. It has good results in most reports. Compared to anterograde drilling, retrograde drilling can protect the integrity of the articular cartilage. The purpose of this study was to evaluate the suitability of using retrograde drilling for osteochondral lesion with subchondral cyst and discuss the mechanism involved in the development of subchondral cyst...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27927688/stereoselective-pharmacokinetics-and-chiral-inversion-of-ibuprofen-in-adjuvant-induced-arthritic-rats
#2
Hiroyuki Ikuta, Atsushi Kawase, Masahiro Iwaki
2-Arylpropionic acid (2-APA) nonsteroidal anti-inflammatory drugs are commonly used in racemic mixtures (rac) for clinical use. 2-APA undergo unidirectional chiral inversion of the in vivo inactive R-enantiomer to the active S-enantiomer. Inflammation causes the reduction of metabolic activities of drug-metabolizing enzymes such as cytochrome P450 (CYP) and UDP-glucuronosyltransferase. However, it is unclear whether inflammation affects the stereoselective pharmacokinetics and chiral inversion of 2-APA such as ibuprofen (IB)...
December 7, 2016: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/27927194/melastoma-malabathricum-linn-attenuates-complete-freund-s-adjuvant-induced-chronic-inflammation-in-wistar-rats-via-inflammation-response
#3
Vikas Kumar, Prakash Chandra Bhatt, Mahfoozur Rahman, Dinesh Kumar Patel, Nikunj Sethi, Atul Kumar, Nikhil Kumar Sachan, Gaurav Kaithwas, F A Al-Abbasi, Firoz Anwar, Amita Verma
BACKGROUND: Natural products use for arthritis treatment is gaining importance in the medical worldt. Various studies reports medical importance of Melastoma malabathricum Linn. (MM) (Melastomataceae), also known as "putki," has a broad range of health benefits, for its free radical scavenging constituents. The current investigation scrutinizes the antioxidant and anti-inflammatory effect of MM against adjuvant-induced arthritis in experimental rats. METHODS: High-performance thin layer chromatography (HPTLC) was used for estimation of phytochemical-constituents present in the MM extract...
December 7, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27920170/epidemiology-of-chikungunya-in-the-americas
#4
Sergio Yactayo, J Erin Staples, Véronique Millot, Laurence Cibrelus, Pilar Ramon-Pardo
Chikungunya virus (CHIKV) emerged in the Americas in late 2013 to cause substantial acute and chronic morbidity. About 1.1 million cases of chikungunya were reported within a year, including severe cases and deaths. The burden of chikungunya is unclear owing to inadequate disease surveillance and underdiagnosis. Virus evolution, globalization, and climate change may further CHIKV spread. No approved vaccine or antiviral therapeutics exist. Early detection and appropriate management could reduce the burden of severe atypical and chronic arthritic disease...
December 15, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27909032/midterm-outcomes-of-polyvinyl-alcohol-hydrogel-hemiarthroplasty-of-the-first-metatarsophalangeal-joint-in-advanced-hallux-rigidus
#5
Timothy R Daniels, Alastair S E Younger, Murray J Penner, Kevin J Wing, Sara Lyn Miniaci-Coxhead, Ellie Pinsker, Mark Glazebrook
BACKGROUND: Hallux rigidus is the most common arthritic condition of the foot. A randomized clinical trial of first metatarsophalangeal (MTP) joint hemiarthroplasty with a polyvinyl alcohol (PVA) hydrogel implant (Cartiva) demonstrated pain relief and functional outcomes equivalent to first MTP arthrodesis at 2 years postoperation, with no cases of implant fragmentation, wear, or bone loss. We prospectively determined 5-year outcomes of first MTP hemiarthroplasty with the PVA hydrogel implant...
November 30, 2016: Foot & Ankle International
https://www.readbyqxmd.com/read/27907047/rage-deficiency-impairs-bacterial-clearance-in-murine-staphylococcal-sepsis-but-has-no-significant-impact-on-staphylococcal-septic-arthritis
#6
Majd Mohammad, Manli Na, Amanda Welin, Mattias N D Svensson, Abukar Ali, Tao Jin, Rille Pullerits
BACKGROUND: Septic arthritis is a serious joint disease often caused by Staphylococcus aureus (S. aureus). Receptor for Advanced Glycation End products (RAGE) has an important role in several infections. We sought to investigate the role of RAGE in staphylococcal septic arthritis and sepsis in mice. METHODS: Wild-type (WT) and RAGE deficient (RAGE-/-) mice were intra-articularly or intravenously inoculated with an arthritic or septic dose of S. aureus LS-1 strain...
2016: PloS One
https://www.readbyqxmd.com/read/27900190/prospective-12-month-functional-and-vocational-outcomes-of-hip-arthroscopy-for-femoroacetabular-impingement-as-part-of-an-evidence-based-hip-pain-rehabilitation-pathway-in-an-active-military-population
#7
A N Bennett, J Nixon, A Roberts, R Barker-Davies, R Villar, J M Houghton
BACKGROUND: Femoroacetabular impingement (FAI) is common with an estimated prevalence of 10-15% among young active individuals. The natural history of the disorder is progression to early osteoarthritis. Hip arthroscopy is recommended if conservative treatments fail; however, outcomes are unclear, particularly in highly active populations. AIM: To evaluate the functional and vocational outcome of hip arthroscopy, as part of an evidence-based rehabilitation hip pain pathway, for the treatment of FAI in an active military population...
2016: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/27896800/principal-component-analysis-in-the-evaluation-of-osteoarthritis
#8
Stephanie E Calce, Helen K Kurki, Darlene A Weston, Lisa Gould
OBJECTIVES: The purpose of this study is to demonstrate advantages of principal component analysis (PCA) as a standardized procedure in the evaluation of osteoarthritis (OA) in a skeletal series to: (1) compute aggregate scores for joint complexes that accurately capture pathological expression, (2) reveal which variables describe the most sample variation in OA, (3) enable inter- and intra-sample comparison of results, and (4) formulate predictive models from component-based arthritic scores...
November 29, 2016: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/27896585/effect-of-an-herbal-mixture-of-cinnamon-cortex-persicae-semen-and-natril-sulfas-on-collagen-induced-arthritis-and-lipopolysaccharides-induced-nuclear-factor-%C3%AE%C2%BA-b-signaling
#9
Ji-Won Lee, Jae-Hwan Lew, Tae-Woo Kim, Hee Kang
OBJECTIVE: To investigate the anti-arthritic and anti-inflammatory effects of the mixture of three herbal agents, Cinnamon Cortex, Persica Semen, and Natril Sulfas (CPN), the major ingredients of Taoren Chengqi Decoction (). METHODS: Collagen-induced arthritis (CIA) was induced by immunization with bovine type II collagen on day 1 and 21. DBA/1J mice were orally administered the water extract of CPN (100 and 500 mg/kg) and indomethacin (1 mg/kg) or vehicle (water) 3 times per week for 6 weeks...
November 17, 2016: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/27895390/maslinic-acid-in-olive-fruit-alleviates-mild-knee-joint-pain-and-improves-quality-of-life-by-promoting-weight-loss-in-the-elderly
#10
Satoshi Fukumitsu, Myra O Villareal, Kazuhiko Aida, Akihiro Hino, Noriya Hori, Hiroko Isoda, Yuji Naito
Consumption of olives (Olea europaea L.) is associated with a low incidence of inflammation-related diseases. Olive fruit is rich in bioactive pentacyclic triterpenoids, mainly maslinic acid. This study, a randomized, double-blind, and placebo-controlled trial, examined the effects of an orally administered maslinic acid supplement, olive fruit extract, on 20 middle-aged and elderly volunteers with mild knee joint pain. Each subject (58 ± 7 years) received either olive fruit extract, containing 50 mg maslinic acid (n = 12), or placebo (n = 8) daily for 12 weeks and evaluated for pain and physical functions as primary outcome measures...
November 2016: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/27891054/patellofemoral-joint-arthroplasty-our-experience-in-isolated-patellofemoral-and-bicompartmental-arthritic-knees
#11
L Sabatini, M Schirò, F Atzori, G Ferrero, A Massè
INTRODUCTION: Isolated patellofemoral (PF) arthritis is rare, and there is no complete agreement about the best surgical treatment. The operative treatments are total knee arthroplasty and patellofemoral replacement (PFR). The incidence of many early complications of PF arthroplasty has decreased with the introduction of newer designs. Nowadays, the main cause of revision surgery is the progression of tibiofemoral osteoarthritis. In the past, PF arthroplasty was contraindicated in patients with evidence of osteoarthritis or pain in medial or lateral tibiofemoral compartments...
2016: Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27882124/-5r-5-hydroxytriptolide-lldt-8-prevents-collagen-induced-arthritis-through-opg-rank-rankl-signaling-in-a-rat-model-of-rheumatoid-arthritis
#12
Ji-Zhou Zeng, Li-Feng Ma, Hai Meng, Hao-Miao Yu, Ya-Kui Zhang, Ai Guo
(5R)-5-hydroxytriptolide (LLDT-8) extracts from Tripterygium have anti-inflammatory, antineoplastic and immunity adjustment functions. The present study used a collagen-induced arthritis (CIA) model to evaluate whether LLDT-8 prevents collagen-induced arthritis, and investigated the signaling underlying this. Male Sprague-Dawley rats were induced to generate CIA, mimicking rheumatoid arthritis (RA). The presence of arthritis was determined using RA progression scores. The inflammatory cytokines interleukin (IL)-1β, IL-6 and nuclear factor-κB were detected using enzyme-linked immunosorbent assay kits...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27881135/cat-s-whiskers-orthosiphon-stamineus-tea-modulates-arthritis-pathogenesis-via-the-angiogenesis-and-inflammatory-cascade
#13
Yasser M Tabana, Fouad Saleih R Al-Suede, Mohamed B Khadeer Ahamed, Saad S Dahham, Loiy E Ahmed Hassan, Saba Khalilpour, Mohamad Taleb-Agha, Doblin Sandai, Aman S Abdul Majid, Amin Malik Shah Abdul Majid
BACKGROUND: Orthosiphon stamineus is used traditionally to treat gout, arthritis, and inflammatory related conditions. The in vitro anti-inflammatory effects of the plant have been scientifically investigated. The goal of the present study was to evaluate the potential of the 50% ethanol extract of O. stamineus (EOS) to treat rheumatoid arthritis. METHODS: Anti-arthritic activity was assessed using the in vitro heat denaturation test and the (FCA)-induced arthritis model...
November 24, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27879675/evaluation-of-hyaluronic-acid-dilutions-at-different-concentrations-using-a-quartz-crystal-resonator-qcr-for-the-potential-diagnosis-of-arthritic-diseases
#14
Luis Armando Carvajal Ahumada, Marco Xavier Rivera González, Oscar Leonardo Herrera Sandoval, José Javier Serrano Olmedo
The main objective of this article is to demonstrate through experimental means the capacity of the quartz crystal resonator (QCR) to characterize biological samples of aqueous dilutions of hyaluronic acid according to their viscosity and how this capacity may be useful in the potential diagnosis of arthritic diseases. The synovial fluid is viscous due to the presence of hyaluronic acid, synthesized by synovial lining cells (type B), and secreted into the synovial fluid thus making the fluid viscous. In consequence, aqueous dilutions of hyaluronic acid may be used as samples to emulate the synovial fluid...
November 22, 2016: Sensors
https://www.readbyqxmd.com/read/27878500/anti-inflammatory-and-antioxidant-effect-of-kerabala-a-value-added-ayurvedic-formulation-from-virgin-coconut-oil-inhibits-pathogenesis-in-adjuvant-induced-arthritis
#15
M Ratheesh, S Sandya, C Pramod, S Asha, Jose P Svenia, S Premlal, B GrishKumar
Kerabala (CB) is a novel ayurvedic formulation used for treating various inflammatory diseases. This formulation was made from virgin coconut oil and it comprises extracts of Sida cordifolia, coconut milk and sesame oil. The current study was performed to evaluate the anti-inflammatory action of CB on carrageenan-induced acute and adjuvant-induced chronic experimental models. 5 mg/kg bwt was found to be potent dose from carrageenan model and evaluated its effect in adjuvant-induced chronic arthritic model...
November 22, 2016: Inflammopharmacology
https://www.readbyqxmd.com/read/27876490/medial-open-wedge-high-tibial-osteotomy-for-varus-malunited-tibial-plateau-fractures
#16
S R Sundararajan, H S Nagaraja, S Rajasekaran
PURPOSE: To analyze radiologic and functional outcomes of varus malunited tibial plateau fractures managed with medial open wedge high tibial osteotomy (MOHTO). METHODS: Eighteen patients with symptomatic varus malunited tibial plateau fractures with less than stage II arthritic changes managed from July 2009 to October 2013 were included. Patients with complex intra-articular step malunions and severe arthritic changes (stage III and IV) were excluded. Initially, diagnostic arthroscopy was performed followed by MOHTO stabilized with locking plate and tricortical autograft (n = 11, 61%) or a Puddu plate and allograft (n = 7, 39%)...
November 19, 2016: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/27872812/anti-inflammatory-effects-of-the-essential-oils-of-ginger-zingiber-officinale-roscoe-in-experimental-rheumatoid-arthritis
#17
Janet L Funk, Jennifer B Frye, Janice N Oyarzo, Jianling Chen, Huaping Zhang, Barbara N Timmermann
Ginger and its extracts have been used traditionally as anti-inflammatory remedies, with a particular focus on the medicinal properties of its phenolic secondary metabolites, the gingerols. Consistent with these uses, potent anti-arthritic effects of gingerol-containing extracts were previously demonstrated by our laboratory using an experimental model of rheumatoid arthritis, streptococcal cell wall (SCW)-induced arthritis. In this study, anti-inflammatory effects of ginger's other secondary metabolites, the essential oils (GEO), which contain terpenes with reported phytoestrogenic activity, were assessed in female Lewis rats with SCW-induced arthritis...
July 2016: PharmaNutrition
https://www.readbyqxmd.com/read/27872515/therapeutic-treatment-of-arthritic-mice-with-15-deoxy-%C3%AE-12-14-prostaglandin-j2-15d-pgj2-ameliorates-disease-through-the-suppression-of-th17-cells-and-the-induction-of-cd4-cd25-foxp3-cells
#18
Vanessa Carregaro, Marcelo H Napimoga, Raphael S Peres, Luciana Benevides, Laís Amorim Sacramento, Larissa G Pinto, Renata Grespan, Thiago M Cunha, João Santana da Silva, Fernando Q Cunha
The prostaglandin, 15-deoxy Δ(12,14)-prostaglandin J2 (15d-PGJ2), is a lipid mediator that plays an important role in the control of chronic inflammatory disease. However, the role of prostanoid in rheumatoid arthritis (RA) is not well determined. We demonstrated the therapeutic effect of 15d-PGJ2 in an experimental model of arthritis. Daily administration of 15d-PGJ2 attenuated the severity of CIA, reducing the clinical score, pain, and edema. 15d-PGJ2 treatment was associated with a marked reduction in joint levels of proinflammatory cytokines...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27857500/inter-observer-variability-and-its-correlation-to-experience-in-measurement-of-lower-limb-mechanical-axis-on-long-leg-radiographs
#19
Raju Vaishya, Vipul Vijay, Vikas P Birla, Amit Kumar Agarwal
INTRODUCTION: Restoration of mechanical axis (MA) is one of the most important aims of treatment of knee arthritis. The measurement of MA is often done on hip knee ankle (HKA) radiographs (LLR), but its measurement is often difficult and variable. We studied to check if inter-observer variability in the measurement of MA is dependent on the experience of the observer. MATERIALS AND METHODS: 48 patients (70 knees) underwent measurement of MA on HKA radiographs. The measurement was done by five observers of different experience...
October 2016: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/27856937/allylpyrocatechol-attenuates-collagen-induced-arthritis-via-attenuation-of-oxidative-stress-secondary-to-modulation-of-the-mapk-jak-stat-and-nrf2-ho-1-pathways
#20
Soumita De, Alak Manna, Sunanda Kundu, Sritama De Sarkar, Uttara Chatterjee, Tuhinadri Sen, Subrata Chattopadhyay, Mitali Chatterjee
Rheumatoid arthritis (RA), an inflammatory autoimmune disorder is characterized by synovial hyperplasia and bony destruction. The pathogenesis of RA includes redox dysregulation, concomitant with increased levels of pro-inflammatory mediators. As the ability of Allylpyrocatechol (APC), a phytoconstituent of Piper betle leaves to alleviate oxidative stress has been demonstrated in patients with RA, its anti-arthritic activity was evaluated in an animal model of arthritis, along with establishment of the underlying mechanism(s) of action...
November 17, 2016: Journal of Pharmacology and Experimental Therapeutics
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