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https://www.readbyqxmd.com/read/28220483/pharmacokinetics-and-pharmacodynamics-of-metamizol-in-co-administration-with-morphine-under-acute-and-chronic-treatments-in-arthritic-rats
#1
Patricia Esmeralda Carrillo-Calzadilla, Francisco Javier López-Muñoz, Luis Alfonso Moreno-Rocha, José Raúl Medina-López, Alma Rosa Cortés-Arroyo, Adriana Miriam Domínguez-Ramírez
OBJECTIVE: To investigate the relationship between metamizol pharmacokinetics and the antinociceptive effect produced after subcutaneous administration of metamizol (177.8 mg/kg) alone or in combination with morphine (3.2 mg/kg), under acute and chronic treatments. METHODS: Antinociception was assessed using the pain-induced functional impairment model in rat (PIFIR). Serial blood samples were collected from the same animals to study the pharmacokinetics of metamizol...
February 21, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28215968/unicompartmental-knee-arthroplasty-vs-total-knee-arthroplasty-for-medial-compartment-arthritis-in-patients-older-than-75-years-comparable-reoperation-revision-and-complication-rates
#2
Homayoun Siman, Atul F Kamath, Nazly Carrillo, William S Harmsen, Mark W Pagnano, Rafael J Sierra
BACKGROUND: Prior studies comparing unicompartmental knee arthroplasty (UKA) with total knee arthroplasty (TKA) in the elderly are limited by heterogeneity in arthritic disease patterns and patient selection. We report the results of UKA and TKA in patients 75 years and older with isolated medial compartmental arthritis, with special emphasis on immediate postoperative recovery, complications, reoperation rates, and implant survivorship at midterm follow-up. METHODS: A retrospective review was performed of all patients 75 years and older who underwent UKA or TKA at our institution between 2002 and 2012...
January 24, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28214173/pyrocarbon-interposition-shoulder-arthroplasty-preliminary-results-from-a-prospective-multicenter-study-at-2-years-of-follow-up
#3
Jérôme Garret, Arnaud Godeneche, Pascal Boileau, Daniel Molé, Mikael Etzner, Luc Favard, Christophe Levigne, François Sirveaux, Marc-Olivier Gauci, Charles Dezaly, Gilles Walch
BACKGROUND: The concept of free interposition arthroplasty proved successful for small joints of the hand, wrist, and foot, particularly after the use of implants coated with pyrocarbon, which enhanced their tribologic and elastic properties. The present study reports preliminary outcomes of a pyrocarbon-coated interposition shoulder arthroplasty (PISA) implant. METHODS: This was a prospective study of 67 consecutive patients who underwent shoulder PISA at 9 centers...
February 14, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28213049/impaired-nk-cell-functionality-and-increased-tnf-%C3%AE-production-as-biomarkers-of-chronic-chikungunya-arthritis-and-rheumatoid-arthritis
#4
Subrat Thanapati, Mohini Ganu, Prashant Giri, Shruti Kulkarni, Meenal Sharma, Prasad Babar, Ashok Ganu, Anuradha S Tripathy
The chronic chikungunya arthritis symptoms closely mimic the rheumatoid arthritis (RA) symptoms, thus making it difficult to distinguish between these two clinical entities. The current comparative study characterizes NK (CD3(-)CD56(+)) and NK-like T (CD3(+)CD56(+)) cell responses in patients with chronic chikungunya arthritis and RA. Phenotype and functions of NK and NK-like T cells repertoire were assessed in 56 chronic chikungunya arthritis, 26 RA patients and 82 controls using flow cytometry. TNF-α and IFN-γ-secreting NK-like T cells were high in both chronic arthritis patients than in controls...
February 14, 2017: Human Immunology
https://www.readbyqxmd.com/read/28208878/a-study-of-medication-compliance-in-geriatric-patients-with-chronic-illnesses-at-a-tertiary-care-hospital
#5
R Shruthi, R Jyothi, H P Pundarikaksha, G N Nagesh, T J Tushar
INTRODUCTION: Geriatric population is more prone for various chronic and recurrent illnesses like diabetes mellitus, hypertension, IHD, arthritic, neurodegenerative, gastrointestinal, ocular, genitourinary, respiratory disorders etc., which may require chronic medication with multiple drugs. Poor compliance in this age group accounts for medication wastage with increased cost of healthcare and substantial worsening of the disease with disability or death. Most of the human and economic costs associated with non adherence can be avoided by improving medication adherence...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28207896/rna-seq-analysis-of-chikungunya-virus-infection-and-identification-of-granzyme-a-as-a-major-promoter-of-arthritic-inflammation
#6
Jane A C Wilson, Natalie A Prow, Wayne A Schroder, Jonathan J Ellis, Helen E Cumming, Linden J Gearing, Yee Suan Poo, Adam Taylor, Paul J Hertzog, Francesca Di Giallonardo, Linda Hueston, Roger Le Grand, Bing Tang, Thuy T Le, Joy Gardner, Suresh Mahalingam, Pierre Roques, Phillip I Bird, Andreas Suhrbier
: Chikungunya virus (CHIKV) is an arthritogenic alphavirus causing epidemics of acute and chronic arthritic disease. Herein we describe a comprehensive RNA-Seq analysis of feet and lymph nodes at peak viraemia (day 2 post infection), acute arthritis (day 7) and chronic disease (day 30) in the CHIKV adult wild-type mouse model. Genes previously shown to be up-regulated in CHIKV patients were also up-regulated in the mouse model. CHIKV sequence information was also obtained with up to ≈8% of the reads mapping to the viral genome; however, no adaptive viral genome changes were apparent...
February 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28202019/anti-arthritic-property-of-crude-extracts-of-piptadeniastrum-africanum-mimosaceae-in-complete-freund-s-adjuvant-induced-arthritis-in-rats
#7
Marius Mbiantcha, Jabeen Almas, Simjee U Shabana, Dastagir Nida, Faheem Aisha
BACKGROUND: Rheumatoid arthritis, disease of unknown causes is a rheumatic and autoimmune pathology, recognised for its increasing frequency and its adverse consequences. It is a disease that occurs in most cases between 50 and 60 years and women are more affected than men. This study aimed at evaluating immunomodulatory and anti-arthritis capacity of aqueous and methanol extracts of stem bark of Piptadeniastrum africanum (Mimosaceae). METHODS: ROS production from phagocytes, proliferation of T-cells, TNF-α and IL-1β production and cytotoxicity were performed by using chemiluminescence technique, liquid scintillation counter, ELISA and MTT assay, respectively...
February 15, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28192100/disease-modifying-anti-rheumatic-activity-of-the-alkaloid-montanine-on-experimental-arthritis-and-fibroblast-like-synoviocytes
#8
Mirian Farinon, Vanessa S Clarimundo, Graziele P R Pedrazza, Pércio S Gulko, José A S Zuanazzi, Ricardo M Xavier, Patricia G de Oliveira
Montanine is an alkaloid isolated from Rhodophiala bifida bulb with potential anti-arthritic activity. In this context, we evaluated whether montanine has a disease modifying anti-rheumatic activity in two arthritis models and its effect in vitro on lymphocyte proliferation and on invasiveness of fibroblast-like synoviocytes (FLS). Antigen-induced arthritis (AIA) was performed in Balb/C mice with methylated bovine serum albumin, and nociception and leukocytes migration into the knee joint were evaluated. Collagen-induced arthritis (CIA) was performed in DBA/1J mice, and arthritis development and severity were assessed by clinical and histological scoring and articular nociception...
February 10, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28191643/cd11b-regulates-via-il-6-the-treg-th17-balance-in-murine-arthritis
#9
Mathias Stevanin, Nathalie Busso, Veronique Chobaz, Matteo Pigni, Sahar Ghassem-Zadeh, Li Zhang, Hans Acha-Orbea, Driss Ehirchiou
Th17 cells are often associated with autoimmunity and been shown to be increased in CD11b(-/-) mice. Here, we examined the role of CD11b in murine collagen-induced arthritis (CIA)-induced arthritis. C57BL/6 and CD11b(-/-) resistant mice were immunized with type II collagen. CD11b(-/-) mice developed arthritis with early onset, high incidence and sustained severity compared with C57BL/6 mice. We observed a marked leukocyte infiltration, and histological examinations of the arthritic paws from CD11b(-/-) mice revealed that the cartilage was destroyed in association with strong lymphocytic infiltration...
February 12, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28187783/development-of-three-dimensional-prints-of-arthritic-joints-for-supporting-patients-awareness-to-structural-damage
#10
Arnd Kleyer, Laura Beyer, Christoph Simon, Fabian Stemmler, Matthias Englbrecht, Christian Beyer, Jürgen Rech, Bernhard Manger, Gerhard Krönke, Georg Schett, Axel J Hueber
BACKGROUND: Rheumatoid arthritis (RA) and psoriatic arthritis (PsA) result in severe joint destruction and functional disability if left untreated. We aim to develop tools that help patients with RA and PsA to understand and experience the impact of inflammatory joint disease on the integrity of their (juxta-articular) bone and increase adherence to medical treatment. In this study, we used high-resolution peripheral quantitative computed tomography (HR-pQCT) to develop 3D prototypes of patients' finger joints...
February 10, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28184957/partial-meniscectomy-provides-no-benefit-for-symptomatic-degenerative-medial-meniscus-posterior-root-tears
#11
Aaron J Krych, Nick R Johnson, Rohith Mohan, Diane L Dahm, Bruce A Levy, Michael J Stuart
PURPOSE: Medial meniscus posterior root tears (MMPRTs) are recognized as a source of pain and dysfunction, but treatment options remain a challenge. The purpose of the study was to determine (1) the efficacy of partial meniscectomy to treat MMPRTs compared to a matched group of non-operatively treated MMPRTs, and (2) risk factors for worse clinical and radiographic outcome. METHODS: This retrospective comparative study was performed to include patients with complete, isolated MMPRTs with documented clinical symptoms and were treated with arthroscopic partial meniscectomy (PMM) and a minimum 2-year follow-up...
February 9, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28183987/in-vivo-hypoxia-pet-imaging-quantifies-the-severity-of-arthritic-joint-inflammation-in-line-with-overexpression-of-hif-and-enhanced-ros-generation
#12
Kerstin Fuchs, Anna Kuehn, Moritz Mahling, Philipp Guenthoer, Andreas Hector, Dominik Hartl, Stefan Laufer, Ursula Kohlhofer, Leticia Quintanilla-Martinez, Gerald Reischl, Martin Röcken, Bernd J Pichler, Manfred Kneilling
Hypoxia is essential for the development of autoimmune diseases such as rheumatoid arthritis (RA) and is associated with the expression of reactive oxygen species (ROS), due to enhanced infiltration of immune cells. The aim of this study was to demonstrate the feasibility of measuring hypoxia non-invasively in vivo in arthritic ankles with positron emission tomography (PET)/magnetic resonance imaging (MRI) using the hypoxia tracers (18)F-fluoromisonidazole (FMISO) and (18)F-fluoroazomycinarabinoside (FAZA)...
February 9, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28181465/the-effect-of-ulnar-variance-on-scapholunate-and-capitolunate-angles
#13
Ozgur Tosun, Atilla Hikmet Çilengir, Berna Dirim Mete, Muhsin Engin Uluc, Orhan Oyar, Aliye Tosun
Background Ulnar variance (UV), which is measured using anteroposterior (AP) X-rays, is associated with the development of multiple wrist pathologies. The scapholunate angle (SLA) and capitolunate angle (CLA) are measured using lateral X-rays, and these can be used in the diagnosis of intercalated segmental instability. Purpose To determine the effect of UV on SLA and CLA. Material and Methods A total of 140 patients (73 women, 67 men; mean age, 37.8 ± 14.6 years; 95% confidence interval [CI], 35.4-40...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28179599/the-immune-dysfunction-in-ankylosing-spondylitis-patients
#14
Zhongliang Duan, Yuyan Gui, Cui Li, Jing Lin, Hans-Jürgen Gober, Juanxiu Qin, Dajin Li, Ling Wang
Ankylosing spondylitis (AS) is a spinal arthritic disease that is often associated with human leukocyte antigen (HLA)-B27, while only part of HLA-B27 carriers become AS patients. T cells have been reported to play an important role in the pathology of AS. T-cell immunoglobulin and mucin-domain-containing molecule 3 (Tim-3) and programmed death-1 (PD-1) have been known to negatively regulate the immune response. In this study, we used flow cytometry to analyze the immunological differences of peripheral bloodfrom 21 patients with AS, 22 cases who didn't have AS but were found to be HLA-B27 positive (HLA-B27+ group), and 16 normal healthy individuals (Healthy group)...
February 7, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/28173831/immunoselected-stro-3-mesenchymal-precursor-cells-reduce-inflammation-and-improve-clinical-outcomes-in-a-large-animal-model-of-monoarthritis
#15
Anwar Abdalmula, Laura M Dooley, Claire Kaufman, Elizabeth A Washington, Jacqueline V House, Barbara A Blacklaws, Peter Ghosh, Silviu Itescu, Simon R Bailey, Wayne G Kimpton
BACKGROUND: The purpose of this study was to investigate the therapeutic efficacy of intravenously administered immunoselected STRO-3 + mesenchymal precursor cells (MPCs) on clinical scores, joint pathology and cytokine production in an ovine model of monoarthritis. METHODS: Monoarthritis was established in 16 adult merino sheep by administration of bovine type II collagen into the left hock joint following initial sensitization to this antigen. After 24 h, sheep were administered either 150 million allogeneic ovine MPCs (n = 8) or saline (n = 8) intravenously (IV)...
February 7, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28167879/early-revision-surgery-for-tibial-plateau-non-union-and-mal-union
#16
Dominic L Van Nielen, Christopher S Smith, David L Helfet, Peter Kloen
BACKGROUND: Although relatively rare, non-unions and mal-unions of tibial plateau fractures present significant challenges for the orthopedic surgeon. With careful pre-operative planning, tibial plateau mal-union or non-union revision surgery with intra-articular and varus opening osteotomies can provides good functional results when performed early (within 1 year) after primary surgical procedure. QUESTIONS/PURPOSES: We present our treatment algorithm for approaching and treating non-union or mal-union of tibial plateau fractures...
February 2017: HSS Journal: the Musculoskeletal Journal of Hospital for Special Surgery
https://www.readbyqxmd.com/read/28167277/purification-of-recombinant-c-reactive-protein-mutants
#17
Avinash Thirumalai, Sanjay K Singh, David J Hammond, Toh B Gang, Donald N Ngwa, Asmita Pathak, Alok Agrawal
C-reactive protein (CRP) is an evolutionarily conserved protein, a component of the innate immune system, and an acute phase protein in humans. In addition to its raised level in blood in inflammatory states, CRP is also localized at sites of inflammation including atherosclerotic lesions, arthritic joints and amyloid plaque deposits. Results of in vivo experiments in animal models of inflammatory diseases indicate that CRP is an anti-pneumococcal, anti-atherosclerotic, anti-arthritic and an anti-amyloidogenic molecule...
February 3, 2017: Journal of Immunological Methods
https://www.readbyqxmd.com/read/28166793/cytotoxic-t-cells-modulate-inflammation-and-endogenous-opioid-analgesia-in-chronic-arthritis
#18
Uta Baddack-Werncke, Melanie Busch-Dienstfertig, Sara González-Rodríguez, Santhosh Chandar Maddila, Jenny Grobe, Martin Lipp, Christoph Stein, Gerd Müller
BACKGROUND: This study examined the development of chronic pain, a cardinal symptom of rheumatoid arthritis (RA), in mice with antigen- and collagen-induced arthritis (ACIA). Since the role of CD8(+) T cells in arthritis is controversial, we investigated the consequences of CD8-depletion on arthritis development and opioid modulation of pain in this novel model of chronic autoimmune arthritis. METHODS: Disease severity in control and CD8-depleted animals was determined by histological assessment of knee-joint sections and measurement of autoantibody formation...
February 6, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28165596/screws-are-not-needed-when-secure-interference-fit-of-uncemented-acetabular-components-is-adequate-a-5-to-15-year-follow-up-with-clinical-and-radiological-analysis
#19
Eduardo García-Rey
PURPOSE: Even with good surgical preparation, adequate primary stability of the acetabular component is not always achieved after primary total hip replacement (THR). We hypothesise that adequate bone preparation for appropriate cortical loading would allow us to avoid screw use. METHODS: A total of 791 uncemented cups were analysed to compare the need for screws to obtain primary fixation in 5 different designs. Arthritic hips with inflammatory arthritis or severe congenital hip disease were excluded...
January 31, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/28162877/humeral-version-in-reverse-shoulder-arthroplasty-affects-impingement-in-activities-of-daily-living
#20
Andreas Kontaxis, Xiang Chen, Julien Berhouet, Daniel Choi, Timothy Wright, David M Dines, Russell F Warren, Lawrence V Gulotta
BACKGROUND: Impingement after reverse shoulder arthroplasty (RSA) has been correlated with implant design and surgical techniques. Previous studies suggested that humeral retroversion can reduce impingement and increase external rotation range of motion (ROM). The purpose of this study was to determine how humeral version affects impingement in activities of daily living (ADLs). MATERIALS AND METHODS: A single surgeon performed virtual RSA on 30 arthritic shoulders that were reconstructed from preoperative computed tomography scans...
February 2, 2017: Journal of Shoulder and Elbow Surgery
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