keyword
MENU ▼
Read by QxMD icon Read
search

Arthrits

keyword
https://www.readbyqxmd.com/read/29053568/mutation-of-a-conserved-nuclear-export-sequence-in-chikungunya-virus-capsid-protein-disrupts-host-cell-nuclear-import
#1
Susan C Jacobs, Adam Taylor, Lara J Herrero, Suresh Mahalingam, John K Fazakerley
Transmitted by mosquitoes; chikungunya virus (CHIKV) is responsible for frequent outbreaks of arthritic disease in humans. CHIKV is an arthritogenic alphavirus of the Togaviridae family. Capsid protein, a structural protein encoded by the CHIKV RNA genome, is able to translocate to the host cell nucleus. In encephalitic alphaviruses nuclear translocation induces host cell shut off; however, the role of capsid protein nuclear localisation in arthritogenic alphaviruses remains unclear. Using replicon systems, we investigated a nuclear export sequence (NES) in the N-terminal region of capsid protein; analogous to that found in encephalitic alphavirus capsid but uncharacterised in CHIKV...
October 20, 2017: Viruses
https://www.readbyqxmd.com/read/29035932/extracellular-vesicles-in-cartilage-homeostasis-and-osteoarthritis
#2
Shigeru Miyaki, Martin K Lotz
PURPOSE OF REVIEW: Extracellular vesicles carry bioactive molecules that can be transferred between cells and tissues. The purpose of this review is to describe how extracellular vesicles regulate functions of cells in cartilage and other joint tissues. The potential application of extracellular vesicles in the treatment of osteoarthritis and as biomarkers will also be discussed. RECENT FINDINGS: Extracellular vesicles are found in synovial fluid, in articular cartilage and in the supernatants of synoviocytes and chondrocytes...
October 13, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29035882/regulation-of-arthritis-severity-by-the-acid-sphingomyelinase
#3
Nadine Beckmann, Katrin Anne Becker, Silke Walter, Jan U Becker, Melanie Kramer, Gabriele Hessler, Stefanie Weber, Joachim R Göthert, Klaus Fassbender, Erich Gulbins, Alexander Carpinteiro
BACKGROUND/AIMS: Rheumatoid arthritis is a chronic autoimmune disease hallmarked by inflammation in synovial joints. Treatment is hampered by the lack of a cure and current disease-modifying drugs are associated with potentially severe toxicities. METHODS: We investigated arthritis severity by measuring joint swelling and pro-inflammatory cytokine production in a murine experimental model of inflammatory arthritis (antigen-induced arthritis). We analyzed acid sphingomyelinase knock-out mice and wild-type littermates, as well as mice treated with the pharmacological acid sphingomyelinase inhibitor amitriptyline...
October 16, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29034192/evaluation-of-analgesic-and-anti-inflammatory-activity-of-bridelia-retusa-spreng-bark
#4
Anil U Tatiya, Ajay K Saluja, Mohan G Kalaskar, Sanjay J Surana, Prakash H Patil
Several species of Bridelia have been used in the condition of pain & arthritis in Indian folk medicine. Present study revealed the preliminary phytochemical investigation and evaluation of analgesic, anti-inflammatory and anti-arthritic activity as well as underlying mechanism of bark of Bridelia retusa Spreng. (Euphorbiaceae). The bark was subjected to extraction using pet.ether, ethyl acetate and acetone. All the extracts were significantly inhibit abdominal writhings response and licking time in late phase of formalin test...
October 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29032304/heterocyclic-homoprostanoid-derivative-attenuates-monoarthritis-in-rats-an-in-vitro-and-in-vivo-preclinical-paradigm
#5
Jayesh Mudgal, S A Manohara Reddy, Geetha Mathew, Anoop Kishore, C Mallikarjuna Rao, Gopalan K Nampurath
From our lab, among the nineteen heterocyclic homoprostanoids (HHPs), three derivatives (compounds 3, 3b and 3c) exerted antioxidant and anti-inflammatory activity. Present study is an extension of the earlier work, and, is designed to establish their therapeutic potential in monoarthritis in rats. In addition, their possible mechanism of action would be investigated. A battery of in vitro tests such as lipopolysaccharide (LPS)-induced nitrite (NO)/reactive oxygen species (ROS) and NO/interleukin (IL)-6 generation in murine macrophages and whole blood (WhB), respectively were conducted...
October 12, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29030641/lubricin-binds-cartilage-proteins-cartilage-oligomeric-matrix-protein-fibronectin-and-collagen-ii-at-the-cartilage-surface
#6
Sarah A Flowers, Agata Zieba, Jessica Örnros, Chunsheng Jin, Ola Rolfson, Lena I Björkman, Thomas Eisler, Sebastian Kalamajski, Masood Kamali-Moghaddam, Niclas G Karlsson
Lubricin, a heavily O-glycosylated protein, is essential for boundary lubrication of articular cartilage. Strong surface adherence of lubricin is required given the extreme force it must withstand. Disulfide bound complexes of lubricin and cartilage oligomeric matrix protein (COMP) have recently been identified in arthritic synovial fluid suggesting they may be lost from the cartilage surface in osteoarthritis and inflammatory arthritis. This investigation was undertaken to localise COMP-lubricin complexes within cartilage and investigate if other cartilage proteins are involved in anchoring lubricin to the joint...
October 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29030522/understanding-and-managing-arthritis
#7
(no author information available yet)
No-one is more surprised than Hannah Capon at her decision to leave clinical practice to help arthritic dogs. This is how it happened.
October 14, 2017: Veterinary Record
https://www.readbyqxmd.com/read/29029974/altered-cardiac-gene-expression-of-noradrenaline-enzymes-transporter-and-%C3%AE-adrenoceptors-in-rat-model-of-rheumatoid-arthritis
#8
Sladjana Dronjak, Bojana Stefanovic, Predrag Jovanovic, Natasa Spasojevic, Milica Jankovic, Ivica Jeremic, Markus Hoffmann
Baseline sympathetic activity was found to be elevated in rheumatoid arthritis (RA) patients and it is related to increased cardiovascular risk in these patients. Although many studies have highlighted the association between RA and increased cardiac sympathetic activity, the underlying mechanistic links remain unclear. The aim of the present study was to understand how diseases-triggered changes in gene expression may result in maladaptive physiological changes. Our results suggest that the equilibrium between noradrenaline synthesis, release and reuptake was disrupted in the ventricles of arthritic rats...
October 6, 2017: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/29029868/does-severe-osteoarthritis-in-knees-with-varus-deformity-alter-the-adductor-ratio
#9
Hakan Boya, S Şükrü Araç
OBJECTIVE: In our retrospective study, we aimed to investigate the differences between the adductor ratio (AR) in knees with and without osteoarthritis, and its validity in determining the articular level. METHODS: Data from 80 knees of 80 patients were retrospectively evaluated. Anteroposterior weight-bearing knee radiographs of the patients with and without osteoarthritis (40 knees in each group) were obtained. The adductor ratio was determined using the following formula: ATJL/FW (adductor tubercle-joint line distance/femoral width)...
October 10, 2017: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/29023411/scientific-study-of-gentiana-kurroo-royle
#10
REVIEW
Bhat Mohd Skinder, Bashir Ahmad Ganai, Abdul Hamid Wani
The present investigation was carried out to review and highlight the potential phytochemicals and medicinal phenomena of the critically endangered medicinal plant, Gentiana kurroo Royle of the western and north-western Himalayas. The medicinal plant is heavily exploited for root and rhizome. Due to its endemic nature and the high rate of exploitation from its natural habitat, this species had become critically endangered. The phytochemical screening of the plant revealed that the plant contains some vital phyto-constituents (iridoids, xanthones, C-glucoxanthone mangiferin, and C-glucoflavones) that have a medicinal value for various acute and chronic diseases...
October 12, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/29022774/the-management-of-chronic-non-arthritic-scapholunate-dissociation-a-systematic-review
#11
Zafar Naqui, Wee Sim Khor, Anuj Mishra, Vivien Lees, Lindsay Muir
A systematic review was conducted to identify the best management for chronic scapholunate dissociation. EMBASE, MEDLINE, and CENTRAL were searched from 1965-2016. A narrative synthesis was performed. One thousand, one hundred and ninety-one citations were identified, of which 17 had final analysis. In all interventions, the pain score at 2 years reduced from 6.0 to 2.8 with similar effect from capsulodesis and tenodesis techniques. Overall there was an 18% loss of flexion arc. Radial to ulnar arc improved in capsulodesis (+19%; n = 45) and worsened in tenodesis (-6%; n = 45)...
January 1, 2017: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/29022241/a-panel-of-protein-candidates-for-comprehensive-study-of-caprine-arthritis-encephalitis-cae-infection
#12
Rosivaldo Quirino Bezerra Júnior, Ângela Maria Xavier Eloy, João Ricardo Furtado, Raymundo Rizaldo Pinheiro, Alice Andrioli, Frederico Bruno Moreno, Marina Duarte Pinto Lobo, Ana Cristina O Monteiro-Moreira, Renato de Azevedo Moreira, Tatiana Maria Farias Pinto, Maria Fátima da Silva Teixeira
The caprine arthrite encephalite (CAE) is a disease that affects especially dairy goat. The virus shows compartmentalization features, that allows it to hide at certain times during the course of the disease, making it difficult to control. The present study was conducted to identify the major seminal plasma protein profile of goats infected by CAE and its associations with seroconversion using Western blotting. Two groups containing five males each, were used in this experiment. The first group was composed by seropositive animals and the control by seronegative confirmed by Western blotting and PCR...
October 12, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/29021102/predictors-of-the-clinical-outcome-and-survival-without-degenerative-arthritis-after-surgical-treatment-of-femoroacetabular-impingement
#13
Nizamettin Kockara, Hakan Sofu, Ahmet Issin, Yalkın Çamurcu, Aysegul Bursali
BACKGROUND: The main purposes of the present study were to evaluate the functional improvement, to identify the predictors of the clinical outcome after open surgical management of femoroacetabular impingement (FAI) in mid-term, and to determine 5-year survival rate. METHODS: In this retrospective study, the clinical data of 33 patients (34 hips) were evaluated. Sex, age, body mass index (BMI), type of FAI, duration of symptoms up to surgical treatment, internal rotation of the affected hip, improvement of the Harris hip score (HHS) in the first 2 years, joint space narrowing evaluated radiographically and classified according to Kellgren-Lawrence classification, and any labral tear were the independent variables...
October 8, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/29019639/spine-conditions-cervical-spine-conditions
#14
Marc A Childress
There are a variety of causes of neck pain, including trauma and degenerative changes. The history of onset helps to direct evaluation, including the need for imaging or ancillary testing. Patterns of pain, weakness, and other specific physical examination findings also aid in diagnosis. Management of most soft tissue injuries involves early mobilization, whereas fractures are managed based on patterns of instability. Acute spinal cord injury requires emergent care, to include possible decompressive surgery...
October 2017: FP Essentials
https://www.readbyqxmd.com/read/29017854/pegylated-trail-ameliorates-experimental-inflammatory-arthritis-by-regulation-of-th17-cells-and-regulatory-t-cells
#15
Jong-Sung Park, Yumin Oh, Ogyi Park, Catherine A Foss, Sung Mook Lim, Dong-Gyu Jo, Dong Hee Na, Martin G Pomper, Kang Choon Lee, Seulki Lee
TNF-related apoptosis-inducing ligand (TRAIL) is a death ligand that can induce apoptosis in cells expressing its cognate death receptors (DRs). Previously, we demonstrated the therapeutic potential of recombinant human TRAIL in experimental rheumatoid arthritis (RA) models. However, the mechanisms of how DR-mediated apoptosis elicits these actions is not known. Here, we show that systemically administering a potent, long-acting PEGylated TRAIL (TRAILPEG) is profoundly anti-rheumatic against two complementary experimental RA mouse models, collagen-induced arthritis (CIA) and collagen antibody-induced arthritis (CAIA), via targeting IL-17 secreting Th17 cells and regulatory T cells (Treg)...
October 7, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29017772/t-cell-activation-rho-gtpase-activating-protein-tagap-is-upregulated-in-clinical-and-experimental-arthritis
#16
Maria Arshad, Attya Bhatti, Peter John, Fazal Jalil, Federica Borghese, Joanna Z Kawalkowska, Richard O Williams, Felix I L Clanchy
Genome-wide association studies have identified various susceptibility variants and loci associated with incidence of rheumatoid arthritis (RA) in different populations. One of these is T cell activation Rho GTPase activating protein (TAGAP). The present study sought to measure the expression of TAGAP in RA patients, CD4(+) T cells subsets from healthy humans and in mice with collagen-induced arthritis. Peripheral blood mononuclear cells (PBMC) from RA patients and tissues of arthritic mice at different stages of the disease were used for the evaluation of TAGAP mRNA expression...
October 7, 2017: Cytokine
https://www.readbyqxmd.com/read/28992165/points-to-consider-for-designing-trials-in-systemic-sclerosis-patients-with-arthritic-involvement
#17
REVIEW
Philip Clements, Yannick Allanore, Daniel E Furst, Dinesh Khanna
Although musculoskeletal involvement is quite common in SSc (arthritic in particular), there have been few trials and even fewer controlled trials of therapeutic agents in arthritis in SSc. In addition, there have been only three outcome measures that have been validated for use in trials of SSc arthritis: the HAQ Disability Index, the Cochin Hand Function Scale and the Hand Mobility in SSc scale. The purpose of this article is to present evidence-based points to consider for the design of trials in SSc patients with musculoskeletal involvement (joints in particular)...
September 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28989252/operculina-turpethum-linn-silva-manso-as-a-medicinal-plant-species-a-review-on-bioactive-components-and-pharmacological-properties
#18
REVIEW
Shweta Gupta, Akash Ved
Operculina turpethum (Linn.) (OT) Silva Manso belongs to the family Convolvulaceae. This review incorporates literature for the phytochemical and pharmacological profile of OT herb. Exhaustive literature survey was done using all the details on phytochemistry and pharmacology of OT available. This herb was found to be a potent source of bioactive compounds such as α- and β-turpethein, turpethinic acids (A, B, C, D, and E), coumarins, cycloartenol, lanosta-5-ene, 24-methylene-δ-5-lanosterol, α- and β-rhamnose, β-sitosterol, lupeol, scopoletin, betulin, acrylamide, stigma-5,22dien-3-O-β-D-glucopyranoside, β-sitosterol-β-D-glucoside (H-1), 22,23-dihydro-α-spinosterol-β-D-glucoside (H-2), and salicylic acid (CH-2), which are useful in fevers, edema, ascites, anorexia, constipation, hepatosplenomegaly, hemorrhoids, cervical lymphadenitis, fistulas, constipation, chronic gout, fever, bronchitis, ulcers, hemorrhoids, tumors, obesity, jaundice, herpes, induce lacrimation, and other skin disorders...
July 2017: Pharmacognosy Reviews
https://www.readbyqxmd.com/read/28983214/factors-associated-with-choice-and-success-of-one-versus-two-stage-revision-arthroplasty-for-infected-hip-and-knee-prostheses
#19
Lucas Castellani, Nick Daneman, Samira Mubareka, Richard Jenkinson
BACKGROUND: Prosthetic joint infections (PJI) of hip and knee arthroplasties are becoming increasingly common with an aging population and an increasing demand for these procedures. Despite attempts at standardization, medical and surgical approaches vary widely among practitioners. QUESTIONS/PURPOSES: We first sought to determine if there were specific factors associated with choice of one- versus two-stage revision. Then we investigated whether the type of revision approach influenced clinical treatment success...
October 2017: HSS Journal: the Musculoskeletal Journal of Hospital for Special Surgery
https://www.readbyqxmd.com/read/28980305/ly6c-high-monocytes-facilitate-transport-of-murid-herpesvirus-68-into-inflamed-joints-of-arthritic-mice
#20
Manon LeBel, Benoit Egarnes, Alexandre Brunet, Patricia Lacerte, Alexandre Paré, Steve Lacroix, Jacques P Brown, Jean Gosselin
Viruses, particularly the Epstein-Barr virus (EBV) has long been suspected to exacerbate acute arthritic symptoms. However, the cell populations that contribute to import viruses into the inflamed tissues remain to be identified. In the present study, we have investigated the role of monocytes in the transport of Murid herpesvirus 68 (MHV-68), a mouse virus closely related to EBV, using the serum transfer-induced arthritis (STIA) model. We found compelling evidence that MHV-68 infection markedly increased disease severity in NR4A1-/- mice, which are deficient for Ly6C(low) monocytes...
October 5, 2017: European Journal of Immunology
keyword
keyword
111126
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"