keyword
MENU ▼
Read by QxMD icon Read
search

Arthrits

keyword
https://www.readbyqxmd.com/read/29453810/a-case-control-study-and-meta-analysis-reveal-the-association-between-cox-2-g-765c-polymorphism-and-primary-end-stage-hip-and-knee-osteoarthritis
#1
Wei Huang, Chen Deng, Feng Tian, Weilu Gao, Zhenfei Ding, Xianliang Rao, Zongsheng Yin
BACKGROUND: Osteoarthritis (OA) is a popular arthrosis featured as pain, limited joint activity, and deformity. Cyclooxygenase-2 (COX-2) has been reported to be up-regulated in arthritic tissues and is integral to the progression of osteoarthritis (OA). Previous studies showed the COX-2 promoter G-765C polymorphism could influence COX-2 expression. However, the relationship between the variant and OA risk is contrasting. METHODS: We conducted a case-control study with 196 primary end-stage hip and knee OA cases and 196 controls in a Chinese Han population...
February 17, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29449195/neutrophil-microvesicles-from-healthy-control-and-rheumatoid-arthritis-patients-prevent-the-inflammatory-activation-of-macrophages
#2
Hefin I Rhys, Francesco Dell'Accio, Costantino Pitzalis, Adrian Moore, Lucy V Norling, Mauro Perretti
Microvesicles (MVs) are emerging as a novel means to enact cell-to-cell communication in inflammation. Here, we aimed to ascertain the ability of neutrophil-derived MVs to modulate target cell behaviour, the focus being the macrophage. MVs were generated in response to tumour necrosis factor-α, from healthy control neutrophils or those from rheumatoid arthritis patients. MVs were used to stimulate human monocyte-derived macrophages in vitro, or administered intra-articularly in the K/BxN mouse model of arthritis...
February 7, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29447014/macrophage-migration-inhibitory-factor-mif-inhibitor-z-590-suppresses-cartilage-destruction-in-adjuvant-induced-arthritis-via-inhibition-of-macrophage-inflammatory-activation
#3
Zhiyu Zhang, Rong Zhang, Linlang Li, Lijun Zhu, Shiyuan Gao, Qiran Lu, Yihui Gu, Yu Zhang, Huicui Yang, Tingjun Hou, Xuechu Zhen, Long Tai Zheng
INTRODUCTION: Macrophage migration inhibitory factor (MIF) is a pleiotropic pro-inflammatory mediator that is involved in the progression of rheumatoid arthritis (RA). Previously, we demonstrated a small molecule compound 3-[(biphenyl-4-ylcarbonyl) carbamothioyl] amino benzoic acid (Z-590) could inhibit MIF activity with docking-based virtual screening and experimental evaluation. MATERIALS AND METHODS: The LPS activated RAW264.7 macrophage cells were used to determine the anti-inflammatory effects of Z-590 in vitro...
February 15, 2018: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/29441250/an-unusual-case-of-acute-chondrocalcinosis-in-wrist-joint-presenting-as-cellulitis
#4
Razia Awan, Haider Ghazanfar, Karen A Martes Pena, Rafi I Farkhad
Chondrocalcinosis is a common arthritic disorder among elderly patients. We present a case of a 71-year-old woman presenting with an acute episode of the left forearm with hand swelling. A provisional diagnosis of cellulitis was made and the patient was started on intravenous antibiotics. The patient's condition did not improve. Joint aspiration of the wrist joint was done and showed positive birefringent rhomboid-shaped crystals. A final diagnosis of acute chondrocalcinosis was made.
December 6, 2017: Curēus
https://www.readbyqxmd.com/read/29437062/mid-term-outcomes-of-routine-proximal-row-carpectomy-compared-with-proximal-row-carpectomy-with-dorsal-capsular-interposition-arthroplasty-for-the-treatment-of-late-stage-arthropathy-of-the-wrist
#5
COMPARATIVE STUDY
M P Gaspar, P P Pham, C D Pankiw, S M Jacoby, E K Shin, A L Osterman, P M Kane
AIMS: The aims of this study were to compare the mid-term outcomes of patients with late-stage arthritis of the wrist treated with proximal row carpectomy (PRC) and dorsal capsular interposition (DCI) arthroplasty with a matched cohort treated with routine PRC alone. PATIENTS AND METHODS: A total of 25 arthritic wrists (24 patients) with pre-existing degenerative changes of the proximal capitate and/or the lunate fossa of the radius were treated with PRC + DCI over a ten-year period...
February 2018: Bone & Joint Journal
https://www.readbyqxmd.com/read/29434332/the-p55tnfr-ikk2-ripk3-axis-orchestrates-arthritis-by-regulating-death-and-inflammatory-pathways-in-synovial-fibroblasts
#6
Marietta Armaka, Caroline Ospelt, Manolis Pasparakis, George Kollias
NFκB activation and regulated cell death are important in tissue homeostasis, inflammation and pathogenesis. Here we show the role of the p55TNFR-IKK2l-Ripk3 axis in the regulation of synovial fibroblast homeostasis and pathogenesis in TNF-mediated mouse models of arthritis. Mesenchymal-specific p55TNFR triggering is indispensable for arthritis in acute and chronic TNF-dependent models. IKK2 in joint mesenchymal cells is necessary for the development of cartilage destruction and bone erosion; however, in its absence synovitis still develops...
February 12, 2018: Nature Communications
https://www.readbyqxmd.com/read/29425654/anti-inflammatory-and-anti-arthritic-effects-of-the-ethanolic-extract-of-aralia-continentalis-kitag-in-il-1%C3%AE-stimulated-human-fibroblast-like-synoviocytes-and-rodent-models-of-polyarthritis-and-nociception
#7
Riwon Hong, BongJun Sur, Mijung Yeom, Bombi Lee, Kyoung Soo Kim, Joyce P Rodriguez, Sanghyun Lee, Ki Sung Kang, Chang-Ki Huh, Sang Cheon Lee, Dae-Hyun Hahm
BACKGROUND: Blocking the formation and invasive growth of pannus and its secretion of inflammatory cytokines and MMPs is important for treating rheumatoid arthritis. HYPOTHESIS/PURPOSE: Anti-arthritic activity of Aralia continentalis Kitag., an oriental herbal medicine, and the underlying mechanisms involved were investigated. STUDY DESIGN: Anti-inflammatory and anti-nocicpetive activities of the ethanolic extract (50% v/v) of Aralia continentalis Kitag...
January 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29423253/clinical-outcomes-of-patients-with-symptomatic-acetabular-rim-fractures-after-arthroscopic-fai-treatment
#8
Brian D Giordano, Carlos Suarez-Ahedo, Chengcheng Gui, Nader Darwish, Parth Lodhia, Benjamin G Domb
This study aims to investigate the influence of the acetabular rim fractures on outcomes of hip arthroscopy at minimum 2-year follow-up. Between January 2009 and August 2012, data were prospectively collected on all patients undergoing hip arthroscopy. Anatomic findings, including presence of rim fractures, were recorded intraoperatively. Patients were assessed preoperatively and at 3 months, 1 year and minimum 2 years postoperatively with four patient-reported outcome measures: modified Harris Hip Score, Non-Arthritic Hip Score, Hip Outcome Score-Activities of Daily Living and Hip Outcome Score-Sport Specific Subscales...
January 2018: Journal of Hip Preservation Surgery
https://www.readbyqxmd.com/read/29416136/proteinases-and-their-receptors-in-inflammatory-arthritis-an-overview
#9
REVIEW
Katerina Oikonomopoulou, Eleftherios P Diamandis, Morley D Hollenberg, Vinod Chandran
Proteinases are enzymes with established roles in physiological and pathological processes such as digestion and the homeostasis, destruction and repair of tissues. Over the past few years, the hormone-like properties of circulating proteinases have become increasingly appreciated. Some proteolytic enzymes trigger cell signalling via proteinase-activated receptors, a family of G protein-coupled receptors that have been implicated in inflammation and pain in inflammatory arthritis. Proteinases can also regulate ion flux owing to the cross-sensitization of transient receptor potential cation channel subfamily V members 1 and 4, which are associated with mechanosensing and pain...
February 8, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/29415905/anti-inflammatory-effects-of-a-small-molecule-gastrin-releasing-peptide-receptor-antagonist-on-adjuvant-induced-rheumatoid-arthritis-in-rats
#10
Wen-Yi Mei, Ming-Jun Yu, Sen Yao, Kui-Ling Wang, Ri-Sheng Yao
The anti-inflammatory effects of (R)-2-(1H-imidazol-1-yl) ethyl-3-(1H-indol-3- yl)-2-(2-p-tolylacetamido)propanamide (RH-1402), a previous designed small molecule Gastrin releasing peptide (GRP) antagonist were evaluated in adjuvant-induced arthritic model of rats, and the inhibitory effect on neutrophil migration induced by GRP was determined by a transwell system experiment in vitro. The arthritis was induced by injection of Complete Freund's Adjuvant (CFA) containing 10 mg/mL of heat killed mycobacterium into the left hind footpad...
February 8, 2018: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29413775/a-comparative-prospective-cohort-health-economic-analysis-comparing-ankle-fusion-isolated-great-toe-fusion-and-hallux-valgus-surgery
#11
David T Loveday, Lynne V Barr, Constantinos L Loizou, Garry Barton, George Smith
BACKGROUND: This study assessed the health economics and outcomes of three common foot and ankle operations. METHODS: Between July 2013 and October 2014 all patients undergoing ankle fusion (AF) for osteoarthritis, first metatarsophalangeal joint fusion for osteoarthritis (MF) or hallux valgus surgery (HV) were included. Patients having additional procedures were excluded. Patients completed the Manchester-Oxford Foot Questionnaire (MOX-FQ), the EuroQol EQ-5D-5L questionnaire and the EQ-VAS on presentation and at least 6 months post-operatively...
February 2018: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29413189/editorial-commentary-wrist-ulnar-impaction-syndrome-when-i-use-the-wafer-procedure-and-when-i-do-not
#12
EDITORIAL
Matthew M Tomaino
Ulnar impaction syndrome is fundamentally a clinical diagnosis, which can be confirmed by magnetic resonance imaging. All palmer stages are amenable to surgical treatment with either arthroscopic wafer procedure (AWP) or ulnar shortening osteotomy, and neither the absence of a triangular fibrocartilage complex perforation nor neutral or negative variance contraindicate either. Because of its minimally invasive value proposition and likely success, there are few clinical scenarios for which I do not perform AWP preferentially...
February 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29409235/the-arthroereisis-procedure-in-adult-flexible-flatfoot-grade-iia-due-to-insufficiency-of-posterior-tibial-tendon
#13
P Ceccarini, G Rinonapoli, G Gambaracci, M Bisaccia, A Ceccarini, A Caraffa
BACKGROUND: To report on the functional, biomechanical, and radiographic results of patients who had undergone arthroereisis plus tensioning of the posterior tibial tendon for flexible flatfoot. The hypothesis is that arthroereisis associated to a tensioning of the posterior tibial tendon give a good correction with great satisfaction in patients with flexible flatfoot in grade IIA. METHODS: We evaluated 29 patients (31 feet), mean age of 46.4 years, who had been surgically treated for adult flatfoot grade IIA according to Myerson...
April 14, 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29408170/acute-phase-reactant-pentraxin-3-as-a-novel-marker-for-the-diagnosis-of-rheumatoid-arthritis
#14
A Sharma, R Khan, N Gupta, A Sharma, M S Zaheer, M Abbas, S A Khan
INTRODUCTION: Pentraxins are a group of highly conserved acute-phase reactant proteins and play crucial role as modulators of inflammatory processes. Pentraxin 3 (PTX3) is primarily produced and released by vascular cell wall, hence, we attempt to establish the role of PTX3 as a biomarker for Rheumatoid Arthritis (RA) compared to CRP. METHODS: Thirty patients having active RA as cases and 30 osteoarthritis (OA) patients as controls were recruited. Paired serum and synovial fluid samples were analysed for concentrations of both PTX3 and CRP by using high sensitivity ELISA kit and ROC curve was plotted...
February 1, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29404675/detection-of-shigella-spp-nucleic-acids-in-the-synovial-tissue-of-tunisian-rheumatoid-arthritis-patients-and-other-forms-of-arthritis-by-quantitative-real-time-polymerase-chain-reaction
#15
Mariam Siala, Markus Rihl, Hanen Sellami, Abir Znazen, Nadia Sassi, Lilia Laadhar, Radhouane Gdoura, Imen Belghuith, Dalila Mrabet, Sofien Baklouti, Slaheddine Sellami, Jean Sibilia, Hela Fourati, Adnene Hammami, Ilhem Cheour
Enterobacterial components in the joints of patients are believed to contribute to a perpetuating inflammation leading to a reactive arthritis (ReA), a condition in which microbial agents cannot be recovered from the joint. At present, it is unclear whether nucleic acids from Shigella spp. are playing a pathogenic role in causing not only ReA but also other forms of arthritis. Quantitative real-time polymerase chain reaction assay (qPCR) is the method of choice for the identification of bacteria within the synovium...
February 5, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29395681/complement-involvement-in-bone-homeostasis-and-bone-disorders
#16
REVIEW
Yvonne Mödinger, Bettina Löffler, Markus Huber-Lang, Anita Ignatius
An integral part of innate immunity is the complement system, a defence system, consisting of fluid-phase and cell surface-bound proteins. Its role to ensure adequate responses to danger factors and thus promoting host defence against pathogens has been well described already for decades. Recently, numerous further reaching functions of complement have been discovered, among these are tissue homeostasis and regeneration, also with respect to the skeletal system. The influence of complement activation on bone was recognised first in pathological conditions of inflamed bone tissue and surrounding areas, observed, for example, in rheumatoid arthritis and osteoarthritis...
January 29, 2018: Seminars in Immunology
https://www.readbyqxmd.com/read/29395553/arthroscopic-ankle-arthrodesis-a-2-15%C3%A2-year-follow-up-study
#17
Christopher Robert Jones, Eric Wong, Gregory R Applegate, Richard D Ferkel
PURPOSE: The purpose of our study was to determine the results of arthroscopic ankle arthrodesis (AAA) and how the procedure affects adjoining joints and functional scores. METHODS: Between 1993 and 2013, 116 patients (120 ankles) underwent AAA. Nineteen ankles were lost to follow-up due to death, insufficient radiographic studies, or inability to contact, resulting in 97 patients (101 ankles). Mean age at surgery was 61.1 years (range, 35.8-79.6 years); mean follow-up was 86 months (range, 24-247 months)...
January 25, 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29392761/clinical-diagnosis-of-temporomandibular-joint-arthritis
#18
Per Alstergren, Maria Pigg, Sigvard Kopp
BACKGROUND: Evidence-based clinical diagnostic criteria for temporomandibular joint (TMJ) arthritis are not available. OBJECTIVE: To establish (i) criteria for clinical diagnosis of TMJ arthritis and (ii) clinical variables useful to determine inflammatory activity in TMJ arthritis using synovial fluid levels of inflammatory mediators as the reference standard. METHODS: A calibrated examiner assessed TMJ pain, function, noise and occlusal changes in 219 TMJs (141 patients, 15 healthy individuals)...
February 2, 2018: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/29391796/in-vivo-therapeutic-efficacy-of-tnf%C3%AE-silencing-by-folate-peg-chitosan-deae-sirna-nanoparticles-in-arthritic-mice
#19
Qin Shi, Elsa-Patricia Rondon-Cavanzo, Isadora Pfeifer Dalla Picola, Marcio José Tiera, Xiaoling Zhang, Kerong Dai, Houda Abir Benabdoune, Mohamed Benderdour, Julio Cesar Fernandes
Background: Tumor necrosis factor-alpha (TNFα), a pro-inflammatory cytokine, has been shown to play a role in the pathophysiology of rheumatoid arthritis. Silencing TNFα expression with small interfering RNA (siRNA) is a promising approach to treatment of the condition. Methods: Towards this end, our team has developed a modified chitosan (CH) nanocarrier, deploying folic acid, diethylethylamine (DEAE) and polyethylene glycol (PEG) (folate-PEG-CH-DEAE15). The gene carrier protects siRNA against nuclease destruction, its ligands facilitate siRNA uptake via cell surface receptors, and it provides improved solubility at neutral pH with transport of its load into target cells...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29391506/therapeutic-effects-of-anti-cd154-antibody-in-cynomolgus-monkeys-with-advanced-rheumatoid-arthritis
#20
Eun Wha Choi, Kyo Won Lee, Hyojun Park, Hwajung Kim, Jong Hyun Lee, Ji Woo Song, Jehoon Yang, Yeongbeen Kwon, Tae Min Kim, Jae Berm Park, Sungjoo Kim
Rheumatoid arthritis is one major chronic inflammatory systemic autoimmune disease. The CD154-CD40 interactions play a critical role in the regulation of immune responses and the maintenance of autoimmunity. Therefore, we aimed to determine whether anti-CD154 antibody treatment show positive effects on immunomodulation and clinical improvement of sustained severe rheumatoid arthritis in cynomolgus monkeys. Arthritis was induced using chicken type II collagen (CII) and arthritic monkey were divided into control and anti-CD154 treatment groups based on their concentrations of anti-CII antibodies on week 7 post-immunization...
February 1, 2018: Scientific Reports
keyword
keyword
111126
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"