Suzanna J Logan, Hong Yin, Beverly Rogers, Nicoleta Arva, Miriam R Conces, Sandy Cope-Yokoyama, Louis P Dehner, Carlos Galliani, Shipra Garg, Mai He, Aliya N Husain, Matthew Keisling, Chandra Krishnan, Elena Puscasiu, Christopher Rossi, Faiza Siddiqui, Lisa Sutton, Jefferson Terry, Ameet I Thaker, Yuan Huang, Jie Zhang, Courtney McCracken, Heather Rytting
INTRODUCTION: The absence of submucosal ganglion cells does not reliably distinguish Hirschsprung disease from non Hirschsprung disease in anorectal line biopsies. Calretinin staining might be helpful in these biopsies. To determine its value, we analyzed calretinin positive mucosal neurites in anorectal line biopsies. METHODS: Two pediatric pathologists, without access to patient data, evaluated calretinin positive mucosal neurites in anorectal line junctional mucosa in archival rectal biopsies contributed by 17 institutions...
November 21, 2022: Pediatric and Developmental Pathology