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https://www.readbyqxmd.com/read/28724822/an-unusual-presentation-of-lacrimal-gland-dirofilariasis
#1
Amit Sethi, Vani Puri, Natasha Dogra
Dirofilariasis is a helminthic infection caused by filarial parasite of the genus Dirofilaria. It is a common zoonotic disease mostly affecting canines and uncommon in humans. It is endemic to Mediterranean countries, with few reports from other parts of the world. The clinical forms in humans are pulmonary, subcutaneous, and ocular. Ocular involvement is rare. We report a case of lacrimal gland dirofilariasis, an unusual ocular presentation which masquerades as a lacrimal gland tumor. Ours would be the third reported case in the world and first in India...
July 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28724093/persistence-of-ascaris-spp-ova-in-tropical-soil-cultivated-with-eucalyptus-and-fertilized-with-municipal-biosolids
#2
Marianne F de Faria, Iraê A Guerrini, Fernando C Oliveira, Maria Inês Z Sato, Elayse M Hachich, José Raimundo S Passos, Lívia M L Goulart, Thiago T de S Silva, José L Gava, Joel C Furches, Jason James, Robert B Harrison
In many countries, the main reason for severely restricting or outright banning the land application of class B biosolids is the lack of risk assessment for adverse human health impacts. Among pathogens that are not often studied are helminth ova, including that of the spp. Almost all of the knowledge about the persistence of spp. ova in soils fertilized with biosolids is based on studies developed in North America, Europe, and Asia. These studies have almost always been conducted under temperate climate conditions, which may cause erroneous interpretations when the conclusions are extrapolated to tropical regions such as those found in Brazil...
May 2017: Journal of Environmental Quality
https://www.readbyqxmd.com/read/28722622/side-benefits-of-mass-drug-administration-for-lymphatic-filariasis-on-strongyloides-stercoralis-prevalence-on-pemba-island-tanzania
#3
Beatrice Barda, Marco Albonico, Dora Buonfrate, Shaali M Ame, Said Ali, Benjamin Speich, Jennifer Keiser
Strongyloides stercoralis, although endemic in many countries, is not included in helminth control programs. Few data are available on the prevalence and morbidity linked to this infection. We compared data from two studies conducted in 1998 and 2013 on Pemba Island, Tanzania, involving 525 and 509 schoolchildren, respectively. In 1998, the diagnostic method used was Harada Mori, whereas in 2013 diagnosis was made by both Koga agar plate and Baermann methods. The prevalence registered was 41% in 1998 and 7% in 2013...
June 19, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28722571/more-poop-more-precision-improving-epidemiologic-surveillance-of-soil-transmitted-helminths-with-multiple-fecal-sampling-using-the-kato-katz-technique
#4
Chengfang Liu, Louise Lu, Linxiu Zhang, Yu Bai, Alexis Medina, Scott Rozelle, Darvin Scott Smith, Changhai Zhou, Wei Zang
Soil-transmitted helminths, or parasitic intestinal worms, are among the most prevalent and geographically widespread parasitic infections in the world. Accurate diagnosis and quantification of helminth infection are critical for informing and assessing deworming interventions. The Kato-Katz thick smear technique, the most widely used laboratory method to quantitatively assess infection prevalence and infection intensity of helminths, has often been compared with other methods. Only a few small-scale studies, however, have considered ways to improve its diagnostic sensitivity...
July 3, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28719642/infections-with-schistosoma-mansoni-and-geohelminths-among-school-children-dwelling-along-the-shore-of-the-lake-hawassa-southern-ethiopia
#5
Bamlaku Tadege, Techalew Shimelis
BACKGROUND: Infections with Schistosoma mansoni and soil-transmitted helminthes (STHs) are major public health problems in Ethiopia. However, information was scarce on the current status of these infections to guide an intervention in the study area. Therefore, this study was conducted to assess the prevalence of infections with S. mansoni and STHs and associated factors among school children in southern Ethiopia. METHODS: This cross-sectional study investigated children who were attending the Finchawa and Tullo junior elementary schools and were residing along the shore of the lake Hawassa in January and February, 2015...
2017: PloS One
https://www.readbyqxmd.com/read/28719325/serologic-monitoring-of-public-health-interventions-against-strongyloides-stercoralis
#6
Paola Vargas, Alejandro J Krolewiecki, Adriana Echazú, Marisa Juarez, Pamela Cajal, Jose F Gil, Nicolás Caro, Julio Nasser, Patrick Lammie, Rubén O Cimino
Northwestern Argentina is endemic for soil-transmitted helminths, and annual deworming programs are carried out in prioritized areas. High prevalence of Strongyloides stercoralis was reported in this area; therefore, control programs including ivermectin are being evaluated. The NIE-enzyme linked immunosorbent assay (ELISA) was used for this purpose. In this community trial, two groups of patients, classified according to housing and living conditions were evaluated. Simultaneous with baseline survey, Group 1 was moved to new households with access to improved water and sanitation facilities (W and S), where deworming (MDA, massive drug administration) took place within 1 month; whereas Group 2 received MDA but remained living with unimproved W and S...
July 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28719290/performance-of-real-time-polymerase-chain-reaction-assays-for-the-detection-of-20-gastrointestinal-parasites-in-clinical-samples-from-senegal
#7
Doudou Sow, Philippe Parola, Khadime Sylla, Magatte Ndiaye, Pascal Delaunay, Philippe Halfon, Sabine Camiade, Thérèse Dieng, Roger C K Tine, Babacar Faye, Jean Louis Ndiaye, Yémou Dieng, Oumar Gaye, Didier Raoult, Fadi Bittar
Gastrointestinal parasite infections represent one of the biggest public health problems in the world. Therefore, appropriate innovative tools are needed for assessing interventions to control these infections. This study aims to compare the performance of real-time polymerase chain reaction (PCR) assays to microscopic examination for detection of intestinal parasites. A direct microscopic examination and stool concentration was performed on 98 stool samples from patients attending Senegalese hospitals. Negative microscopic control samples were also collected in Nice and Marseille (France)...
July 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28719267/comparison-of-cytokine-responses-in-ecuadorian-children-infected-with-giardia-ascaris-or-both-parasites
#8
Jill Weatherhead, Andrea Arévalo Cortés, Carlos Sandoval, Maritza Vaca, Martha Chico, Sophia Loor, Philip J Cooper, Rojelio Mejia
AbstractMore than 2 billion people are infected with parasites globally, and the majority have coinfections. Intestinal protozoa and helminths induce polarizing CD4(+) T-helper cell 1 (Th1) mediated cytokine responses within the host. Such immune polarization may inhibit the ability of the host to mount an adequate immune response for pathogen clearance to concurrent pathogens. The current study evaluated the plasma cytokine profile in Ascaris and Giardia coinfected children compared with Giardia- and Ascaris-only infected children...
June 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28717850/physio-biochemical-parameters-a-potential-tool-for-target-selective-treatment-of-haemonchosis-in-the-small-ruminants
#9
Bhupamani Das, Niranjan Kumar, Mehul M Jadav, Jayesh B Solanki, T K S Rao
This study aims to evaluate the conjunctiva colour-based FAMACHA score (FS) coupled with a body condition score (BCS), haemogram and stressor hormone level estimation, in identifying post-mortem (PM)/coproscopically proven individuals wanting therapy for economically important gastrointestinal (GI) helminths, Haemonchus contortus, in the small ruminants. The incidence of haemonchosis was significantly (p < 0.05) higher (60.81%) in the ruminants with FS = 3. The H. contortus count in the animals with FS 2, 3 and 4 was 23...
July 17, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28716804/type-i-interferon-is-required-for-t-helper-th-2-induction-by-dendritic-cells
#10
Lauren M Webb, Rachel J Lundie, Jessica G Borger, Sheila L Brown, Lisa M Connor, Adam Nr Cartwright, Annette M Dougall, Ruud Hp Wilbers, Peter C Cook, Lucy H Jackson-Jones, Alexander T Phythian-Adams, Cecilia Johansson, Daniel M Davis, Benjamin G Dewals, Franca Ronchese, Andrew S MacDonald
Type 2 inflammation is a defining feature of infection with parasitic worms (helminths), as well as being responsible for widespread suffering in allergies. However, the precise mechanisms involved in T helper (Th) 2 polarization by dendritic cells (DCs) are currently unclear. We have identified a previously unrecognized role for type I IFN (IFN-I) in enabling this process. An IFN-I signature was evident in DCs responding to the helminth Schistosoma mansoni or the allergen house dust mite (HDM). Further, IFN-I signaling was required for optimal DC phenotypic activation in response to helminth antigen (Ag), and efficient migration to, and localization with, T cells in the draining lymph node (dLN)...
July 17, 2017: EMBO Journal
https://www.readbyqxmd.com/read/28716158/efficacy-of-single-dose-500-mg-mebendazole-in-soil-transmitted-helminth-infections-a-review
#11
J Mrus, B Baeten, M Engelen, S A Silber
Soil-transmitted helminthiasis (STH) is caused by Ascaris lumbricoides (roundworm), Trichuris trichiura (whipworm), and Ancylostoma duodenale and Necator americanus (hookworms). Mebendazole is one of the recommended preventive chemotherapy agents for STH. This review summarizes the efficacy data from 29 studies with single-dose 500 mg mebendazole in STH treatment and compares the results with those of a recently conducted phase 3 study of a 500 mg mebendazole chewable tablet against A. lumbricoides and T. trichiura infections...
July 18, 2017: Journal of Helminthology
https://www.readbyqxmd.com/read/28715423/antibody-trapping-a-novel-mechanism-of-parasite-immune-evasion-by-the-trematode-echinostoma-caproni
#12
Alba Cortés, Javier Sotillo, Carla Muñoz-Antolí, Javier Molina-Durán, J Guillermo Esteban, Rafael Toledo
BACKGROUND: Helminth infections are among the most prevalent neglected tropical diseases, causing an enormous impact in global health and the socioeconomic growth of developing countries. In this context, the study of helminth biology, with emphasis on host-parasite interactions, appears as a promising approach for developing new tools to prevent and control these infections. METHODS/PRINCIPAL FINDINGS: The role that antibody responses have on helminth infections is still not well understood...
July 17, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28713432/haematological-profile-and-intensity-of-urogenital-schistosomiasis-in-ghanaian-children
#13
Justice Afrifa, Desmond Gyedu, Eric Ofori Gyamerah, Samuel Essien-Baidoo, Isaac Mensah-Essilfie
BACKGROUND: Urogenital schistosomiasis is a widely contracted parasitic helminth infection often associated with haematological abnormalities. AIM: We investigated the relationship between the haematological profile and the intensity of schistosomiasis among children in the Yeji district. MATERIALS AND METHODS: A total of 100 participants comprising 50 Schistosoma haematobium (S. haematobium) infected and 50 noninfected controls aged 6-17 years matched for age and sex were recruited into the study...
2017: Journal of Environmental and Public Health
https://www.readbyqxmd.com/read/28708895/yeast-expressed-recombinant-as16-protects-mice-against-ascaris-suum-infection-through-induction-of-a-th2-skewed-immune-response
#14
Junfei Wei, Leroy Versteeg, Zhuyun Liu, Brian Keegan, Ana Clara Gazzinelli-Guimarães, Ricardo T Fujiwara, Neima Briggs, Kathryn M Jones, Ulrich Strych, Coreen M Beaumier, Maria Elena Bottazzi, Peter J Hotez, Bin Zhan
BACKGROUND: Ascariasis remains the most common helminth infection in humans. As an alternative or complementary approach to global deworming, a pan-anthelminthic vaccine is under development targeting Ascaris, hookworm, and Trichuris infections. As16 and As14 have previously been described as two genetically related proteins from Ascaris suum that induced protective immunity in mice when formulated with cholera toxin B subunit (CTB) as an adjuvant, but the exact protective mechanism was not well understood...
July 14, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28705749/in-vitro-effect-of-metrifonate-on-the-indices-of-oxidative-stress-in-gigantocotyle-explanatum
#15
Mohammad Ahmad, Murad A Mubaraki, Mohammed Ali M Marie
Helminth infections in general and digenetic trematodes in particular cause a huge economic loss globally to our livestock. Gigantocotyle explanatum is a digenetic amphistome that infects the bile ducts of water buffalo and are highly prevalent in tropical and sub-tropical countries. In the present study, effects of an organophosphate compound, Metrifonate (MF) in three doses, viz., 9.4 × 10(-5) M (Dose I), 14.4 × 10(-5) M (Dose II), and 19.4 × 10(-5) M (Dose III), have been studied in vitro, on the motility and on some enzymatic and non-enzymatic oxidative stress indices in G...
July 10, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28705595/excretory-secretory-antigens-of-strongyloides-venezuelensis-applied-to-igg-detection-in-human-strongyloidosis
#16
Renata A Cunha, Edson F G de Carvalho, José E N de Sousa, Julia M Costa-Cruz
Strongyloidosis is a neglected disease that affects millions of people around the world. The cases that particularly deserve attention are those related to hyperinfection, mainly in immunocompromised patients. In this sense, there is a need to improve the serological diagnosis of this helminth. The objective of this study was therefore to produce and characterize excretory/secretory (E/S) antigens of Strongyloides venezuelensis infective larvae (L3) for use as a heterologous antigen in the diagnosis of human strongyloidosis and other parasitic infection groups...
July 10, 2017: Parasitology International
https://www.readbyqxmd.com/read/28704038/eosinophilic-meningitis-caused-by-angiostrongylus-cantonensis
#17
Shan Lv, Xiao-Nong Zhou, Jason R Andrews
Rat lungworm, Angiostrongylus cantonensis, is one major cause of human eosinophilic meningitis. This helminth is endemic in Southeast Asia, Pacific Islands, and the Caribbean and has recently expanded to South America. The infection is characterized by an elevated eosinophil count in cerebrospinal fluid. Common symptoms and signs include headache, neck stiffness, paresthesia and nausea/vomiting. The unique history of eating freshwater and land snails or slugs within 2 weeks before onset is helpful for diagnosis...
July 13, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28703913/a-suum-infection-modulates-inflammation-implication-of-cd4-cd25-hi-foxp3-t-cells-and-il-10
#18
Tiago de Oliveira Titz, Claudia Andréa Alves de Araújo, Cristina Satomi Enobe, Paula Ordonhez Rigato, Telma Miyuki Oshiro, Maria Fernanda de Macedo-Soares
Helminth infections have the ability to modulate host's immune response through mechanisms that allow the chronic persistence of the worms in the host. Here, we investigated the mechanisms involved on the suppressive effect of Ascaris suum infection using a murine experimental model of LPS-induced inflammation. We found that infection with A. suum markedly inhibited leukocyte influx induced by LPS into air pouches, suppressed secretion of pro-inflammatory cytokines (IL-1β, TNF-α and IL-6) and induced high levels of IL-10 and TGF-β...
July 13, 2017: Parasite Immunology
https://www.readbyqxmd.com/read/28702376/nematode-species-identification-current-status-challenges-and-future-perspectives-for-cyathostomins
#19
Christina M Bredtmann, Jürgen Krücken, Jayaseelan Murugaiyan, Tetiana Kuzmina, Georg von Samson-Himmelstjerna
Human and animal health is globally affected by a variety of parasitic helminths. The impact of co-infections and development of anthelmintic resistance requires improved diagnostic tools, especially for parasitic nematodes e.g., to identify resistant species or attribute pathological effects to individual species or particular species combinations. In horses, co-infection with cyathostomins is rather a rule than an exception with typically 5 to 15 species (out of more than 40 described) per individual host...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28701221/helminth-infections-and-practice-of-prevention-and-control-measures-among-pregnant-women-attending-antenatal-care-at-anbesame-health-center-northwest-ethiopia
#20
Melashu Balew Shiferaw, Amtatachew Moges Zegeye, Agmas Dessalegn Mengistu
BACKGROUND: Helminth infections have a terrible impact on child growth and development, and harm pregnant women. Regular treatment and long term preventive interventions are important measures to break the transmission routes. Hence, identifying the status of helminth infection and practices of prevention and control measures among pregnant women is important in different geographical areas of Ethiopia including our setting. METHODS: A cross-sectional study was conducted on 180 pregnant women from March to June, 2015...
July 12, 2017: BMC Research Notes
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