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https://www.readbyqxmd.com/read/29036211/orally-administered-taenia-solium-calreticulin-prevents-experimental-intestinal-inflammation-and-is-associated-with-a-type-2-immune-response
#1
Fela Mendlovic, Mayra Cruz-Rivera, Jose Alfredo Diaz-Gandarilla, Marco Antonio Flores-Torres, Guillermina Avila, Maria Perfiliev, Ana Maria Salazar, Lourdes Arriaga-Pizano, Patricia Ostrosky-Wegman, Ana Flisser
Intestinal helminth antigens are inducers of type 2 responses and can elicit regulatory immune responses, resulting in dampened inflammation. Several platyhelminth proteins with anti-inflammatory activity have been reported. We have identified, cloned and expressed the Taenia solium calreticulin (rTsCRT) and shown that it predominantly induces a type 2 response characterized by IgG1, IL-4 and IL-5 production in mice. Here, we report the rTsCRT anti-inflammatory activity in a well-known experimental colitis murine model...
2017: PloS One
https://www.readbyqxmd.com/read/29035384/effect-of-anthelmintic-treatment-on-leptin-adiponectin-and-leptin-to-adiponectin-ratio-a-randomized-controlled-trial
#2
D L Tahapary, K de Ruiter, I Martin, E A T Brienen, L van Lieshout, Y Djuardi, C C Djimandjaja, J J Houwing-Duistermaat, P Soewondo, E Sartono, T Supali, J W A Smit, M Yazdanbakhsh
Emerging evidence suggests that helminths might confer protection against the development of type 2 diabetes. We aimed to assess the role of adipokines in mediating the effect of helminths on insulin resistance. Serum samples were obtained from a randomized-controlled trial of anthelmintic treatment in an area endemic for soil-transmitted helminths (STH), Flores Island, Indonesia. In STH-infected subjects, anthelmintic treatment significantly increased the ratio of leptin to adiponectin (treatment effect factor (95% confidence interval (CI)), P-value for interaction: 1...
October 16, 2017: Nutrition & Diabetes
https://www.readbyqxmd.com/read/29033926/micrornas-in-taenia-solium-neurocysticercosis-insights-as-promising-agents-in-host-parasite-interaction-and-their-potential-as-biomarkers
#3
REVIEW
Renzo Gutierrez-Loli, Miguel A Orrego, Oscar G Sevillano-Quispe, Luis Herrera-Arrasco, Cristina Guerra-Giraldez
MicroRNAs (miRNAs) are short, endogenous, non-coding, single-stranded RNAs involved in post-transcriptional gene regulation. Although, several miRNAs have been identified in parasitic helminths, there is little information about their identification and function in Taenia. Furthermore, the impact of miRNAs in neurocysticercosis, the brain infection caused by larvae of Taenia solium is still unknown. During chronic infection, T. solium may activate numerous mechanisms aimed to modulate host immune responses...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29032785/two-glutathione-transferase-isoforms-isolated-from-juvenile-cysts-of-taenia-crassiceps-identification-purification-and-characterization
#4
G Maldonado, G Nava, A Plancarte
We identified and characterized the first two glutathione transferases (GSTs) isolated from juvenile cysts of Taenia crassiceps (EC 2.5.1.18). The two glutathione transferases (TcGST1 and TcGST2) were purified in a single-step protocol using glutathione (GSH)-sepharose chromatography in combination with a GSH gradient. The specific activities of TcGST1 and TcGST2 were 26 U mg-1 and 19 U mg-1, respectively, both at 25°C and pH 6.5 with 1-chloro-2,4-dinitrobenzene (CDNB) and GSH as substrates. The K m(CDNB) and K cat(CDNB) values for TcGST1 and TcGST2 (0...
October 16, 2017: Journal of Helminthology
https://www.readbyqxmd.com/read/29031202/targeting-of-cell-cycle-and-let-7a-stat3-pathway-by-niclosamide-inhibits-proliferation-migration-and-invasion-in-oral-squamous-cell-carcinoma-cells
#5
Xiaoxu Li, Ruiyu Ding, Zewen Han, Zeyun Ma, Yixiang Wang
The low median survival rate of oral squamous cell carcinoma (OSCC) is associated with chemotherapeutic resistance. Niclosamide is an oral anti-helminthic drug, its anti-cancer effect has been reported in recent years. However, the effect of niclosamide on OSCC remains largely unknown. In this study, we, for the first time, investigated the underlying mechanisms from cell cycle arrest and let-7a/STAT3 axis through CCK-8, cell cycle, apoptosis, wound healing, Transwell invasion, generation of stable cell line, real-time PCR, and western blot assays using two OSCC cell lines WSU-HN6 and Tca83...
October 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29028844/a-polyphenol-enriched-diet-and-ascaris-suum-infection-modulate-mucosal-immune-responses-and-gut-microbiota-composition-in-pigs
#6
Andrew R Williams, Lukasz Krych, Hajar Fauzan Ahmad, Peter Nejsum, Kerstin Skovgaard, Dennis S Nielsen, Stig M Thamsborg
Polyphenols are a class of bioactive plant secondary metabolites that are thought to have beneficial effects on gut health, such as modulation of mucosal immune and inflammatory responses and regulation of parasite burdens. Here, we examined the interactions between a polyphenol-rich diet supplement and infection with the enteric nematode Ascaris suum in pigs. Pigs were fed either a basal diet or the same diet supplemented with grape pomace (GP), an industrial by-product rich in polyphenols such as oligomeric proanthocyanidins...
2017: PloS One
https://www.readbyqxmd.com/read/29027962/novel-therapeutics-for-multiple-sclerosis-designed-by-parasitic-worms
#7
REVIEW
Aakanksha Dixit, Akane Tanaka, Judith M Greer, Sheila Donnelly
The evolutionary response to endemic infections with parasitic worms (helminth) was the development of a distinct regulatory immune profile arising from the need to encapsulate the helminths while simultaneously repairing tissue damage. According to the old friend's hypothesis, the diminished exposure to these parasites in the developed world has resulted in a dysregulated immune response that contributes to the increased incidence of immune mediated diseases such as Multiple Sclerosis (MS). Indeed, the global distribution of MS shows an inverse correlation to the prevalence of helminth infection...
October 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29027596/10-year-parasitological-examination-results-2003-to-2012-of-faecal-samples-from-horses-ruminants-pigs-dogs-cats-rabbits-and-hedgehogs
#8
Katharina Raue, Lea Heuer, Claudia Böhm, Sonja Wolken, Christian Epe, Christina Strube
The results of coproscopical examinations in domestic animals and hedgehogs carried out as routine diagnostics in the years 2003 to 2012 at the Institute for Parasitology, University of Veterinary Medicine Hannover, Germany, are presented. Of 3475 horse faecal samples, 30.1% contained stages of strongyles and 1.3% eggs of Strongyloides westeri and Parascaris equorum, respectively. The most frequently observed parasite stages in 1416 cattle faecal samples were Eimeria oocysts (21.3%) and strongyle eggs or larvae (15...
October 13, 2017: Parasitology Research
https://www.readbyqxmd.com/read/29024642/epithelial-cell-derived-phospholipase-a2-group-1b-is-an-endogenous-anthelmintic
#9
Lewis J Entwistle, Victoria S Pelly, Stephanie M Coomes, Yashaswini Kannan, Jimena Perez-Lloret, Stephanie Czieso, Mariana Silva Dos Santos, James I MacRae, Lucy Collinson, Abdul Sesay, Nikolay Nikolov, Amina Metidji, Helena Helmby, David Y Hui, Mark S Wilson
Immunity to intestinal helminth infections has been well studied, but the mechanism of helminth killing prior to expulsion remains unclear. Here we identify epithelial-cell-derived phospholipase A2 group 1B (PLA2g1B) as a host-derived endogenous anthelmintic. PLA2g1B is elevated in resistant mice and is responsible for killing tissue-embedded larvae. Despite comparable activities of other essential type-2-dependent immune mechanisms, Pla2g1b(-/-) mice failed to expel the intestinal helminths Heligmosomoides polygyrus or Nippostrongylus brasiliensis...
October 11, 2017: Cell Host & Microbe
https://www.readbyqxmd.com/read/29024637/pla2g1b-places-worms-in-peril
#10
Mark Palma, Darine W El-Naccache, William C Gause
The determinants of helminth resistance are not well understood. In this issue of Cell Host & Microbe, Entwistle et al. (2017) provide intriguing evidence that a phospholipase A2 (Pla2gb1) produced by epithelial cells can impair larval development in helminths, providing a novel mechanism contributing to intestinal nematode resistance.
October 11, 2017: Cell Host & Microbe
https://www.readbyqxmd.com/read/29023699/using-host-species-traits-to-understand-the-consequences-of-resource-provisioning-for-host-parasite-interactions
#11
Daniel J Becker, Daniel G Streicker, Sonia Altizer
1.Supplemental food provided to wildlife by human activities can be more abundant and predictable than natural resources, and subsequent changes to wildlife ecology can have profound impacts on host-parasite interactions. Identifying traits of species associated with increases or decreases in infection outcomes with resource provisioning could improve assessments of wildlife most prone to disease risks in changing environments. 2.We conducted a phylogenetic meta-analysis of 342 host-parasite interactions across 56 wildlife species and three broad taxonomic groups of parasites to identify host-level traits that influence whether provisioning is associated with increases or decreases in infection...
October 10, 2017: Journal of Animal Ecology
https://www.readbyqxmd.com/read/29018152/correction-cutting-edge-helminth-coinfection-blocks-effector-differentiation-of-cd8-t-cells-through-alternate-host-th2-and-il-10-mediated-responses
#12
Andrew Marple, Wenhui Wu, Suhagi Shah, Yanlin Zhao, Peicheng Du, William C Gause, George S Yap
No abstract text is available yet for this article.
October 15, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29017470/soil-transmitted-helminthiasis-and-associated-risk-factors-among-elementary-school-children-in-ambo-town-western-ethiopia
#13
Fikreslasie Samuel, Asalif Demsew, Yonas Alem, Yonas Hailesilassie
BACKGROUND: Soil-transmitted helminths (STHs) are widespread in underdeveloped countries. In Ethiopia, the prevalence and distribution of helminth infection varies by different exposing risk factors. We therefore investigated the prevalence of and risk factors of STHs infection in school children living in Ambo town, west Shoa Ethiopia. METHODS: In 2014/15, among 375 school children planed to be included in this study, only 321 school children were recruited in the study...
October 10, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29016318/effects-of-boiling-drinking-water-on-diarrhea-and-pathogen-specific-infections-in-low-and-middle-income-countries-a-systematic-review-and-meta-analysis
#14
Alasdair Cohen, John M Colford
Globally, approximately 2 billion people lack microbiologically safe drinking water. Boiling is the most prevalent household water treatment method, yet evidence of its health impact is limited. To conduct this systematic review, we searched four online databases with no limitations on language or publication date. Studies were eligible if health outcomes were measured for participants who reported consuming boiled and untreated water. We used reported and calculated odds ratios (ORs) and random-effects meta-analysis to estimate pathogen-specific and pooled effects by organism group and nonspecific diarrhea...
September 5, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28991924/application-of-a-loop-mediated-isothermal-amplification-lamp-assay-targeting-cox1-gene-for-the-detection-of-clonorchis-sinensis-in-human-fecal-samples
#15
S M Mazidur Rahman, Hyun Beom Song, Yan Jin, Jin-Kyoung Oh, Min Kyung Lim, Sung-Tae Hong, Min-Ho Choi
BACKGROUND: Clonorchiasis is prevalent in the Far East, and a major health problem in endemic areas. Infected persons may experience, if not treated, serious complications such as bile stone formation, pyogenic cholangitis, and even cholangiocarcinoma. Early diagnosis and treatment are important to prevent serious complications and, therefore, the simple and reliable diagnostic method is necessary to control clonorchiasis in endemic areas, where resources for the diagnosis are limited...
October 9, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28991899/albendazole-and-ivermectin-for-the-control-of-soil-transmitted-helminths-in-an-area-with-high-prevalence-of-strongyloides-stercoralis-and-hookworm-in-northwestern-argentina-a-community-based-pragmatic-study
#16
Adriana Echazú, Marisa Juarez, Paola A Vargas, Silvana P Cajal, Ruben O Cimino, Viviana Heredia, Silvia Caropresi, Gladys Paredes, Luis M Arias, Marcelo Abril, Silvia Gold, Patrick Lammie, Alejandro J Krolewiecki
BACKGROUND: Recommendations for soil-transmitted helminth (STH) control give a key role to deworming of school and pre-school age children with albendazole or mebendazole; which might be insufficient to achieve adequate control, particularly against Strongyloides stercoralis. The impact of preventive chemotherapy (PC) against STH morbidity is still incompletely understood. The aim of this study was to assess the effectiveness of a community-based program with albendazole and ivermectin in a high transmission setting for S...
October 9, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28991894/sanitation-hookworm-anemia-stunting-and-wasting-in-primary-school-children-in-southern-ethiopia-baseline-results-from-a-study-in-30-schools
#17
Jack E T Grimes, Gemechu Tadesse, Iain A Gardiner, Elodie Yard, Yonas Wuletaw, Michael R Templeton, Wendy E Harrison, Lesley J Drake
BACKGROUND: Inadequate nutrition; neglected topical diseases; and insufficient water, sanitation, and hygiene (WASH) are interrelated problems in schools in low-income countries, but are not routinely tackled together. A recent three-year longitudinal study investigated integrated school health and nutrition approaches in 30 government primary schools in southern Ethiopia. Here, we report on baseline associations between sanitation, hookworm infection, anemia, stunting, and wasting. METHODS: In each school, the Schistosoma mansoni, S...
October 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28990934/mast-cell-hyperactivity-underpins-the-development-of-oxygen-induced-retinopathy
#18
Kenshiro Matsuda, Noriko Okamoto, Masatoshi Kondo, Peter D Arkwright, Kaoru Karasawa, Saori Ishizaka, Shinichi Yokota, Akira Matsuda, Kyungsook Jung, Kumiko Oida, Yosuke Amagai, Hyosun Jang, Eiichiro Noda, Ryota Kakinuma, Koujirou Yasui, Uiko Kaku, Yasuo Mori, Nobuyuki Onai, Toshiaki Ohteki, Akane Tanaka, Hiroshi Matsuda
Mast cells are classically thought to play an important role in protection against helminth infections and in the induction of allergic diseases; however, recent studies indicate that these cells also contribute to neovascularization, which is critical for tissue remodeling, chronic inflammation, and carcinogenesis. Here, we demonstrate that mast cells are essential for sprouting angiogenesis in a murine model of oxygen-induced retinopathy (OIR). Although mouse strains lacking mast cells did not exhibit retinal neovascularization following hypoxia, these mice developed OIR following infusion of mast cells or after injection of mast cell tryptase (MCT)...
October 9, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28988538/high-prevalence-of-soil-transmitted-helminth-infections-among-primary-school-children-uttar-pradesh-india-2015
#19
Sandipan Ganguly, Sharad Barkataki, Sumallya Karmakar, Prerna Sanga, K Boopathi, K Kanagasabai, P Kamaraj, Punam Chowdhury, Rituparna Sarkar, Dibyendu Raj, Leo James, Shanta Dutta, Rakesh Sehgal, Priya Jha, Manoj Murhekar
BACKGROUND: Soil-transmitted helminth (STH) infections often affect the poorest and most deprived communities. In order to generate reliable data for planning a school based deworming program, we conducted a survey among primary school children studying in government schools in the Indian state of Uttar Pradesh. The objectives of our survey were to estimate the prevalence and intensity of STH infections. METHODS: We conducted a cross-sectional survey among children studying in 130 primary schools from 9 agro-climatic zones, during May - August 2015...
October 9, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28986531/experimental-testing-of-reciprocal-effects-of-nutrition-and-parasitism-in-wild-black-capuchin-monkeys
#20
Ilaria Agostini, Ezequiel Vanderhoeven, Mario S Di Bitetti, Pablo M Beldomenico
Nutritional stress may predispose individuals to infection, which in turn can have further detrimental effects on physical condition, thus creating an opportunity for reciprocal effects between nutrition and parasitism. Little experimental investigation has been conducted on this "vicious circle" hypothesis in wild animals, especially under natural conditions. We evaluated the reciprocal effects of nutritional status and parasitism using an experimental approach in two groups of wild black capuchin monkeys (Sapajus nigritus)...
October 6, 2017: Scientific Reports
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