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Raimunda C Dos Santos, Alicia S Ombredane, Jéssica Maria T Souza, Andreanne G Vasconcelos, Alexandra Plácido, Adriany das G N Amorim, Eder Alves Barbosa, Filipe C D A Lima, Cristina D Ropke, Michel M M Alves, Daniel D R Arcanjo, Fernando A A Carvalho, Cristina Delerue-Matos, Graziella A Joanitti, José Roberto de S A Leite
This study investigated a lycopene-rich extract from red guava (LEG) for its chemical composition using spectrophotometry, mass spectrometry, attenuated total reflectance-fourier transform infrared spectroscopy (ATR-FTIR), and computational studies. The cytotoxic activity of LEG and the underlying mechanism was studied in human breast adenocarcinoma cells (MCF-7), murine fibroblast cells (NIH-3T3), BALB/c murine peritoneal macrophages, and sheep blood erythrocytes by evaluating the cell viability with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method and flow cytometry...
March 2018: Food Research International
Christos Liolios, Benjamin Buchmuler, Ulrike Bauder-Wüst, Martin Schaefer, Karin Leotta, Uwe Haberkorn, Matthias Eder, Klaus Kopka
The GRPr, highly expressed in prostate PCa and breast cancer BCa, is a promising target for the development of new PET radiotracers. The chelator HBED-CC (N,N'-bis[2-hydroxy-5-(carboxyethyl)benzyl]ethylenediamine-N,N'-diacetic acid) was coupled to the bombesin peptides: HBED-C-BN(2-14) 1, HBED-CC-PEG 2 -[D-Tyr 6 ,β-Ala 11 ,Thi 13 ,Nle 14 ]-BN(6-14) 2, HBED-CC-Y-[D-Phe 6 ,Sta 13 ,Leu 14 ]-BN(6-14), (Y = 4-amino-1-carboxymethyl-piperidine) 3 and HBED-CC-{PEG 2 -Y-[D-Phe 6 ,Sta 13 ,Leu 14 ]-BN(6-14)} 2 4 (homodimer)...
February 12, 2018: Journal of Medicinal Chemistry
Gurjit S Kaeley, Lihi Eder, Sibel Z Aydin, Marwin Gutierrez, Catherine Bakewell
OBJECTIVE: To describe the growing importance of enthesitis in patients with psoriatic arthritis (PsA) and discuss the advantages and disadvantages of clinical and imaging methods currently used to assess enthesitis. METHODS: PubMed literature searches were conducted using the terms psoriatic arthritis, entheses, enthesitis, pathology, imaging, ultrasound, magnetic resonance imaging, clinical, and indices. Articles were deemed relevant if they provided insight into the pathology, monitoring, and/or diagnosis of enthesitis in PsA, or if they discussed clinical or imaging indices used to assess enthesitis...
January 6, 2018: Seminars in Arthritis and Rheumatism
Clara Eder, Lila Kumar Khatiwada, Janine Schooley
Objectives Few studies have been undertaken to determine whether and how project results are sustained. University of Notre Dame (ND) and Project Concern International conducted a Post-Project Sustainability Study (PSS) of a USAID-funded program (CHOICE), implemented in Indonesia, Banten province, between 2003 and 2007, in order to determine lasting effects and improve PSS methodologies. Methods Sustainability was measured through a comparison of data collected on mother-infant pairs in 2014 with final evaluation data from 2007; and through a comparison of 2014 data collected from the CHOICE villages and comparison villages...
February 10, 2018: Maternal and Child Health Journal
Lihi Eder, Paula Harvey, Vinod Chandran, Cheryl F Rosen, Jan Dutz, James T Elder, Proton Rahman, Christopher T Ritchlin, Sherry Rohekar, Richard Hayday, Snezana Barac, Joy Feld, Devy Zisman, Dafna D Gladman
OBJECTIVE: We aimed to estimate the proportion of underdiagnosis and undertreatment of cardiovascular risk factors (CVRF) in an international multicenter cohort of patients with psoriasis and psoriatic arthritis (PsA). METHODS: A cross-sectional analysis was conducted of patients with psoriatic disease from the International Psoriasis and Arthritis Research Team cohort. The presence of modifiable CVRF [diabetes, hypertension (HTN), dyslipidemia, smoking, elevated body mass index, and central obesity] and the use of appropriate therapies for HTN and dyslipidemia were determined...
February 1, 2018: Journal of Rheumatology
Fernando Gonçalves, Ricardo S Bovendorp, Gabrielle Beca, Carolina Bello, Raul Costa-Pereira, Renata L Muylaert, Raisa R Rodarte, Nacho Villar, Rafael Souza, Maurício E Graipel, Jorge J Cherem, Deborah Faria, Julio Baumgarten, Martín R Alvarez, Emerson M Vieira, Nilton Cáceres, Renata Pardini, Yuri L R Leite, Leonora P Costa, Marco A R Mello, Erich Fischer, Fernando C Passos, Luiz H Varzinczak, Jayme A Prevedello, Ariovaldo P Cruz-Neto, Fernando Carvalho, Alexandre R Percequillo, Agustin Paviolo, Alessandra Nava, José M B Duarte, Noé U de la Sancha, Enrico Bernard, Ronaldo G Morato, Juliana F Ribeiro, Rafael G Becker, Gabriela Paise, Paulo S Tomasi, Felipe Vélez-Garcia, Geruza L Melo, Jonas Sponchiado, Felipe Cerezer, Marília A S Barros, Albérico Q S de Souza, Cinthya C Dos Santos, Gastón A F Giné, Patricia Kerches-Rogeri, Marcelo M Weber, Guilherme Ambar, Lucía V Cabrera-Martinez, Alan Eriksson, Maurício Silveira, Carolina F Santos, Lucas Alves, Eder Barbier, Gabriela C Rezende, Guilherme S T Garbino, Élson O Rios, Adna Silva, Alexandre Túlio A Nascimento, Rodrigo S de Carvalho, Anderson Feijó, Juan Arrabal, Ilaria Agostini, Daniela Lamattina, Sebastian Costa, Ezequiel Vanderhoeven, Fabiano R de Melo, Plautino de Oliveira Laroque, Leandro Jerusalinsky, Mônica M Valença-Montenegro, Amely B Martins, Gabriela Ludwig, Renata B de Azevedo, Agustin Anzóategui, Marina X da Silva, Marcela Figuerêdo Duarte Moraes, Alexandre Vogliotti, Andressa Gatti, Thomas Püttker, Camila S Barros, Thais K Martins, Alexine Keuroghlian, Donald P Eaton, Carolina L Neves, Marcelo S Nardi, Caryne Braga, Pablo R Gonçalves, Ana Carolina Srbek-Araujo, Poliana Mendes, João A de Oliveira, Fábio A M Soares, Patrício A Rocha, Peter Crawshaw, Milton C Ribeiro, Mauro Galetti
Measures of traits are the basis of functional biological diversity. Numerous works consider mean species-level measures of traits while ignoring individual variance within species. However, there is a large amount of variation within species and it is increasingly apparent that it is important to consider trait variation not only between species, but also within species. Mammals are an interesting group for investigating trait-based approaches because they play diverse and important ecological functions (e...
February 2018: Ecology
Tobias Weller, Leonie Deilmann, Jana Timm, Tobias S Dörr, Peter A Beaucage, Alexey S Cherevan, Ulrich B Wiesner, Dominik Eder, Roland Marschall
We have prepared the first crystalline and 3D periodically ordered mesoporous quaternary semiconductor photocatalyst in an evaporation-induced self-assembly assisted soft-templating process. Using lab synthesized triblock-terpolymer poly(isoprene-b-styrene-b-ethylene oxide) (ISO) a highly ordered 3D interconnected alternating gyroid morphology was achieved exhibiting near and long-range order, as evidenced by small angle X-ray scattering (SAXS) and electron microscopy (TEM/SEM). Moreover, we reveal the formation process on the phase-pure construction of the material's pore-walls with its high crystallinity, which proceeds along a highly stable W5+ compound, by both in situ and ex situ analyses, including X-ray powder diffraction (XRPD), Fourier transform infrared spectroscopy (FTIR) and electron paramagnetic resonance (EPR)...
January 31, 2018: Nanoscale
Douglas Rangel Goulart, Eder Alberto Sigua-Rodriguez, Rodrigo Fariña, Sergio Olate
The diagnosis of unilateral condylar hyperplasia (UCH) requires a combined assessment consisting of clinical, radiological, and histopathological examination. The etiology of this condition is unknown. The purpose of this study is to report a rare case of UCH in a monozygotic twin. A 15-year-old girl was referred to our department complaining of facial asymmetry and malocclusion. Computed tomography and single-photon emission computed tomography imaging reveal enlargement of the left condyle and condylar neck, and an increased uptake that was diagnosed as active UCH...
January 19, 2018: Journal of Craniofacial Surgery
Jessica C Huss, Vanessa Schoeppler, David J Merritt, Christine Best, Eric Maire, Jérôme Adrien, Oliver Spaeker, Nils Janssen, Johannes Gladisch, Notburga Gierlinger, Ben P Miller, Peter Fratzl, Michaela Eder
Heat-triggered fruit opening and delayed release of mature seeds are widespread among plants in fire-prone ecosystems. Here, the material characteristics of the seed-containing follicles of Banksia attenuata (Proteaceae), which open in response to heat frequently caused by fire, are investigated. Material analysis reveals that long-term dimensional stability and opening temperatures of follicles collected across an environmental gradient increase as habitats become drier, hotter, and more fire prone. A gradual increase in the biaxial curvature of the hygroscopic valves provides the follicles in the driest region with the highest flexural rigidity...
January 2018: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
I Krela-Kazmierczak, A Wawrzyniak, A Szymczak, P Eder, L Lykowska-Szuber, M Michalak, N Drweska-Matelska, M Kaczmarek-Rys, M Skrzypczak-Zielinska, M Szalata, R Slomski
Finding genetic predictors of osteoporosis and fractures in patients with inflammatory bowel disease (IBD) may provide incentives for non-pharmacological actions and so improve the long-term prognosis of the patients. We analysed the incidence of BMP2 570A>T polymorphic variants and their association with bone mineral density (BMD) and the incidence of fractures in patients with IBD. The study comprised 198 IBD patients (100 with Crohn's disease (CD), and 98 with ulcerative colitis, (UC)) and 41 healthy controls...
October 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
M Port, M Majewski, F Herodin, M Valente, M Drouet, F Forcheron, A Tichy, I Sirak, A Zavrelova, A Malkova, B V Becker, D A Veit, S Waldeck, C Badie, G O'Brien, H Christiansen, J Wichmann, M Eder, G Beutel, J Vachelova, S Doucha-Senf, M Abend
The research for high-throughput diagnostic tests for victims of radio/nuclear incidents remains ongoing. In this context, we have previously identified candidate genes that predict risk of late-occurring hematologic acute radiation syndrome (HARS) in a baboon model. The goal of the current study was to validate these genes after radiation exposure in humans. We also examined ex vivo relative to in vivo measurements in both species and describe dose-response relationships. Eighteen baboons were irradiated in vivo to simulate different patterns of partial- or total-body irradiation (TBI), corresponding to an equivalent dose of 2...
January 26, 2018: Radiation Research
Claudia Paret, Alexandra Russo, Henrike Otto, Arnulf Mayer, Sebastian Zahnreich, Wolfgang Wagner, David Samuel, David Scharnhorst, David A Solomon, Girish Dhall, Kenneth Wong, Hannah Bender, Francesca Alt, Arthur Wingerter, Marie A Neu, Olaf Beck, Dirk Prawitt, Stefan Eder, Nicole Henninger, Khalifa El Malki, Nadine Lehmann, Nora Backes, Lea Roth, Larissa Seidmann, Clemens Sommer, Marc A Brockmann, Gundula Staatz, Heinz Schmidberger, Jörg Faber
High-grade neuroepithelial tumor of the central nervous system with BCOR alteration (HGNET-BCOR) is a rare, highly malignant tumor. At the time of this publication, no standard protocol exists to treat this tumor entity. In this work, we tested the responsiveness of the primary culture PhKh1 derived from tumor tissue from a pediatric HGNET-BCOR patient (P1) to inhibitors of the Sonic hedgehog pathway combined with radiation. The SMO inhibitors vismodegib and itraconazole had low effect on the proliferation of the PhKh1 cells...
December 26, 2017: Oncotarget
Vanessa H S Zago, Fernanda Alexandre, Daniel Z Scherrer, Natália B Panzoldo, Jamal Baracat, Erica I L Gomes, Vanessa M Rebolla, Eder C R Quintão, Eliana C De Faria
No abstract text is available yet for this article.
August 2017: Atherosclerosis
Ari Polachek, Richard Cook, Vinod Chandran, Fatima Abji, Dafna Gladman, Lihi Eder
OBJECTIVE: Enthesitis is an important pathophysiologic component in psoriatic arthritis (PsA). Human Leukocyte Antigen (HLA) genes are implicated in the pathogenesis of PsA. Little is known about the relation between HLA genetic susceptibility markers and enthesitis in PsA patients. Our aim was to examine the association between HLA genetic susceptibility markers and sonographic enthesitis in PsA. METHODS: A cross-sectional analysis was conducted in patients with PsA...
January 23, 2018: Arthritis & Rheumatology
Nilton Custodio, Rosa Montesinos, David Lira, Eder Herrera-Perez, Yadira Bardales, Lucia Valeriano-Lorenzo
There is limited evidence about the progression of cognitive performance during the post-stroke stage. Objective: To assess the evolution of cognitive performance in stroke patients without vascular cognitive impairment (VCI), patients with vascular mild cognitive impairment (MCI), and patients with vascular dementia (VD). Methods: A prospective cohort of stroke outpatients from two secondary medical centers in Lima, Peru was studied. We performed standardized evaluations at definitive diagnosis (baseline evaluation), and control follow-ups at 6 and 12 months, including a battery of short cognitive tests: Clinical Dementia Rating (CDR), Addenbrooke's Cognitive Examination (ACE), and INECO Frontal Screening (IFS)...
October 2017: Dementia & Neuropsychologia
Nilton Custodio, Rosa Montesinos, David Lira, Eder Herrera-Pérez, Yadira Bardales, Lucía Valeriano-Lorenzo
Mixed dementia is the coexistence of Alzheimer's disease and cerebrovascular disease (CVD) in the same demented patient. Currently, its diagnosis and treatment remains a challenge for practitioners. To provide an overview of the epidemiology, pathogenesis, natural history, diagnosis, and therapy of Mixed Vascular-Alzheimer Dementia (MVAD). The literature was reviewed for articles published between 1990-2016 by using the keywords linked to MVAD. Neuropathological studies indicate that MVAD is a very common pathological finding in the elderly with a prevalence about of 22%...
October 2017: Dementia & Neuropsychologia
Daniel Kaup, Janine Keller, Erika Most, Joachim Geyer, Klaus Eder, Robert Ringseis
Background: Recently, supplementation of L-carnitine to obese rats was found to improve the carnitine status and to counteract an obesity-induced muscle fiber transition from type I to type II. However, it has not been resolved if the change of muscle fiber distribution induced in obese rats and the restoration of the "normal" muscle fiber distribution, which is found in lean rats, in obese rats by supplemental L-carnitine is causally linked with the carnitine status. In the present study we hypothesized that fiber type distribution in skeletal muscle is dependent on carnitine status...
2018: Nutrition & Metabolism
Adriana Amorim Francisco, Sonia Maria Junqueira Vasconcellos De Oliveira, Mary Steen, Moacyr Roberto Cuce Nobre, Eder Viana De Souza
BACKGROUND: Ice-pack is widely used for alleviating postpartum perineal pain sustained after birth related perineal trauma. However, it lacks robust evidence on timing and frequency of applications, to ensure the effective and safe use of this therapy. AIMS: To evaluate if a 10min ice-pack application relieved postpartum perineal pain and if the analgesic effect was maintained for up to 2h. METHODS: A randomised controlled trial conducted from December 2012 to February 2013 with 69 primiparous women ≥18 years old, 6-24h postpartum, with perineal pain ≥3, who had not received anti-inflammatory medication or analgesics after childbirth, who were randomised to a single ice-pack application on the perineum for 10min or standard care...
January 11, 2018: Women and Birth: Journal of the Australian College of Midwives
Lihi Eder, Arnon Dov Cohen, Ilan Feldhamer, Sari Greenberg-Dotan, Erez Batat, Devy Zisman
BACKGROUND: There is limited information on the epidemiology of psoriatic arthritis (PsA) in general and in Middle Eastern populations in particular. The aims of this study were to estimate the prevalence and incidence rates of PsA and their temporal trends in the general population in Israel. METHODS: In this study, a cohort of adult patients with PsA was derived from the database of Clalit Health Services (CHS), Israel's largest health fund, with over 4.4 million members...
January 2, 2018: Arthritis Research & Therapy
Melissa K Cousino, Kurt R Schumacher, Kelly E Rea, Sally Eder, Mary Zamberlan, Jessica Jordan, Emily M Fredericks
Across pediatric organ transplant populations, patient and family psychosocial functioning is associated with important health-related outcomes. Research has suggested that pediatric heart transplant recipients and their families are at increased risk for adverse psychosocial outcomes; however, recent investigation of psychosocial functioning in this population is lacking. This study aimed to provide a contemporary characterization of psychosocial functioning in pediatric heart transplant recipients and their families...
January 5, 2018: Pediatric Transplantation
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