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https://www.readbyqxmd.com/read/29215771/p16-positivity-and-regression-grade-predict-survival-after-neoadjuvant-radiotherapy-of-oscc
#1
Christina Eder-Czembirek, Irene Sulzbacher, Thorsten Fuereder, Edgar Selzer
OBJECTIVES: Survival after preoperative radiotherapy in locally advanced head and neck squamous cell cancer is associated with pathological response. The prognostic importance of p16 expression in these patients has not been established yet. MATERIALS AND METHODS: Ninety-seven oral squamous cell carcinoma patients, treated preoperatively with radiotherapy in combination with chemotherapy or cetxuximab, were included in this retrospective analysis. Survival rates were estimated by the Kaplan-Meyer method...
December 7, 2017: Oral Diseases
https://www.readbyqxmd.com/read/29215552/two-distinct-clinical-courses-of-human-cowpox-germany-2015
#2
Ines Eder, Patrick Vollmar, Martin Pfeffer, Philipp Naether, Arne Christian Rodloff, Hermann Meyer
Here we present two cases of human infection with cowpox virus with distinct clinical courses. A series of clinical photographs documents lesion progression over time. In the first case-an unvaccinated young veterinary assistant-a pustule was treated locally with cortisone. The lesion turned into a large ulcer accompanied by severe lymphadenitis. Based on her close contact to a sick stray cat, infection with cowpox virus was assumed and confirmed by virus isolation, PCR, and serology. The clinical course took up to eleven months until healing of the wound was complete...
December 7, 2017: Viruses
https://www.readbyqxmd.com/read/29215297/virulence-genes-and-antimicrobial-resistance-in-escherichia-coli-from-cheese-made-from-unpasteurized-milk-in-brazil
#3
Anna C L P de Campos, Juan J Puño-Sarmiento, Leonardo P Medeiros, Luís E S Gazal, Renato Pariz Maluta, Armando Navarro, Renata K T Kobayashi, Eder P Fagan, Gerson Nakazato
Cow raw milk cheese is widely eaten in Brazil. These products may be contaminated with pathogenic bacteria. In this work, we investigated the presence of Escherichia coli in raw milk cheese from different States in Brazil. From 147 "Minas" cheese samples, 28 cheeses were positive for E. coli. Among 39 E. coli isolates of the cheeses, one was positive for eae and negative for bpfA and efa1/lifA using PCR, and so was classified as atypical Enteropathogenic E. coli (aEPEC). Two other isolates were positive for extraintestinal pathogenic E...
December 7, 2017: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/29204249/dietary-polyphenols-in-the-prevention-of-stroke
#4
REVIEW
A Tressera-Rimbau, S Arranz, M Eder, A Vallverdú-Queralt
Polyphenols have an important protective role against a number of diseases, such as atherosclerosis, brain dysfunction, stroke, cardiovascular diseases, and cancer. Cardiovascular diseases are the number one cause of death worldwide: more people die annually from cardiovascular diseases than from any other cause. The most important behavioural risk factors of heart disease and stroke are unhealthy diet, physical inactivity, tobacco use, and excess alcohol intake. The dietary consumption of polyphenols has shown to be inversely associated with morbidity and mortality by cardio- and cerebrovascular diseases...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29192336/identification-of-opossums-didelphis-aurita-wied-neuweid-1826-as-a-definitive-host-of-sarcocystis-falcatula-like-sporocysts
#5
Samira Salim Mello Gallo, David Scott Lindsay, Nicole Brand Ederli, Filipe Pereira Matteoli, Thiago Motta Venancio, Francisco Carlos Rodrigues de Oliveira
This study was conducted to identify the Sarcocystis species that infect the opossum Didelphis aurita in order to determine which sporocysts they are excreating in to the environment and help determine the role of D. aurita in the epidemiology of Sarcocystis. Sporocysts were obtained from intestinal tracts of 8 of 13 D. aurita trapped in Rio de Janeiro state, Brazil, and were orally inoculated into Melopsittacus undulatus and Balb/c nude Mus musculus. Portions of organs and muscles were processed for histology, immunohistochemistry, transmission electron microscopy (TEM), and PCR using primers JNB 33/54, and ITS...
December 1, 2017: Parasitology Research
https://www.readbyqxmd.com/read/29191856/psma-11-derived-dual-labeled-psma-inhibitors-for-preoperative-pet-imaging-and-precise-fluorescence-guided-surgery-of-prostate-cancer
#6
Ann-Christin Baranski, Martin Schäfer, Ulrike Bauder-Wüst, Mareike Roscher, Jana Schmidt, Esther Stenau, Tobias Simpfendörfer, Dogu Teber, Lena Maier-Hein, Boris Hadaschik, Uwe Haberkorn, Matthias Eder, Klaus Kopka
Resection of tumor lesions using targeted dual-modality probes combining preoperative imaging with intraoperative guidance is of high clinical relevance and might considerably impact the outcome of prostate cancer therapy. This work aims at the development of dual-labeled prostate specific membrane antigen (PSMA)-inhibitors derived from the established positron emission tomography (PET)- and N,N'-bis[2-hydroxy-5-(carboxyethyl)benzyl]ethylenediamine-N,N'-diacetic acid (HBED-CC) based tracer 68Ga-Glu-urea-Lys(Ahx)-HBED-CC (68Ga-PSMA-11) to allow accurate intraoperative detection of PSMA-positive tumor lesions...
November 30, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29189764/a-comprehensive-approach-to-motorcycle-related-head-injury-prevention-experiences-from-the-field-in-vietnam-cambodia-and-uganda
#7
Greig Craft, Truong Van Bui, Mirjam Sidik, Danielle Moore, David J Ederer, Erin M Parker, Michael F Ballesteros, David A Sleet
Motorcyclists account for 23% of global road traffic deaths and over half of fatalities in countries where motorcycles are the dominant means of transport. Wearing a helmet can reduce the risk of head injury by as much as 69% and death by 42%; however, both child and adult helmet use are low in many countries where motorcycles are a primary mode of transportation. In response to the need to increase helmet use by all drivers and their passengers, the Global Helmet Vaccine Initiative (GHVI) was established to increase helmet use in three countries where a substantial portion of road users are motorcyclists and where helmet use is low...
November 30, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29189047/combined-serum-free-light-chain-levels-are-associated-with-carotid-atherosclerosis-in-type-2-diabetes-mellitus
#8
Felix Aberer, Norbert Joachim Tripolt, Hubert Scharnagl, Julian Zedler, Michaela Eder, Abderrahim Oulhaj, Tatjana Stojakovic, Harald Sourij
BACKGROUND: Patients with type 2 diabetes mellitus face an increased risk of cardiovascular events compared to non-diabetic counterparts. Chronic inflammation and activation of the immune system, including B-lymphocyte maturation is believed to play a role in atherosclerosis. Recent investigations suggest combined serum free light chains as a potential biomarker for cardiovascular events. The aim of this analysis was to investigate the association of combined serum free light chain with carotid atherosclerosis in subjects with type 2 diabetes mellitus...
November 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29186396/genome-sequencing-of-chlamydia-trachomatis-serovars-e-and-f-reveals-substantial-genetic-variation
#9
Thomas Eder, Stefanie Kobus, Sonja Stallmann, Stefanie Stepanow, Karl Köhrer, Johannes H Hegemann, Thomas Rattei
Chlamydia trachomatis (Ctr) is a bacterial pathogen that causes ocular, urogenital and lymph system infections in humans. It is highly abundant and among its serovars, E, F and D are most prevalent in sexually transmitted disease. However, the number of publicly available genome sequences of the serovars E and F, and thereby our knowledge about the molecular architecture of these serovars, is low. Here we sequenced the genomes of six E and F clinical isolates and one E lab strain, in order to study the genetic variance in these serovars...
November 24, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/29176993/an-excess-dietary-vitamin-e-concentration-does-not-influence-nrf2-signaling-in-the-liver-of-rats-fed-either-soybean-oil-or-salmon-oil
#10
Klaus Eder, Marina Siebers, Erika Most, Susan Scheibe, Norbert Weissmann, Denise K Gessner
Background: Reactive oxygen species (ROS) are known to stimulate the activation of nuclear factor-erythroid 2-related factor-2 (Nrf2), the key regulator of the antioxidant and cytoprotective defense system in the body. The hypothesis underlying this study was that high dietary concentrations of vitamin E suppress Nrf2 activation, and thus could weaken the body's antioxidative and cytoprotective capacity. As the effect of vitamin E on Nrf2 pathway might be influenced by concentrations of fatty acids susceptible to oxidation in the diet, we used also diets containing either soybean oil as a reference oil or salmon oil as a source of oil rich in n-3 polyunsatuated fatty acids...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29162516/structure-and-function-of-a-novel-antioxidant-peptide-from-the-skin-of-tropical-frogs
#11
Eder Barbosa, Ana Oliveira, Alexandra Plácido, Renato Socodato, Camila C Portugal, Ana Carolina Mafud, Alicia S Ombredane, Daniel C Moreira, Nuno Vale, Lucinda J Bessa, Graziella A Joanitti, Cláudia Alves, Paula Gomes, Cristina Delerue-Matos, Yvonne Primerano Mascarenhas, Mariela M Marani, João B Relvas, Manuela Pintado, José Roberto S A Leite
The amphibian skin plays an important role protecting the organism from external harmful factors such as microorganisms or UV radiation. Based on biorational strategies, many studies have investigated the cutaneous secretion of anurans as a source of bioactive molecules. By a peptidomic approach, a novel antioxidant peptide (AOP) with in vitro free radical scavenging ability was isolated from Physalaemus nattereri. The AOP, named antioxidin-I, has a molecular weight [M+H](+) = 1543.69Da and a TWYFITPYIPDK primary amino acid sequence...
November 18, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29158508/switching-between-h-and-j-type-electronic-coupling-in-single-conjugated-polymer-aggregates
#12
Theresa Eder, Thomas Stangl, Max Gmelch, Klaas Remmerssen, Dirk Laux, Sigurd Höger, John M Lupton, Jan Vogelsang
The aggregation of conjugated polymers and electronic coupling of chromophores play a central role in the fundamental understanding of light and charge generation processes. Here we report that the predominant coupling in isolated aggregates of conjugated polymers can be switched reversibly between H-type and J-type coupling by partially swelling and drying the aggregates. Aggregation is identified by shifts in photoluminescence energy, changes in vibronic peak ratio, and photoluminescence lifetime. This experiment unravels the internal electronic structure of the aggregate and highlights the importance of the drying process in the final spectroscopic properties...
November 21, 2017: Nature Communications
https://www.readbyqxmd.com/read/29158269/the-glucocorticoid-receptor-is-a-key-player-for-prostate-cancer-cell-survival-and-a-target-for-improved-anti-androgen-therapy
#13
Martin Puhr, Julia Hoefer, Andrea Eigentler, Christian Ploner, Florian Handle, Georg Schaefer, Jan Kroon, Angela Leo, Isabel M Heidegger, Iris E Eder, Zoran Culig, Gabri van der Pluijm, Helmut Klocker
PURPOSE: The major obstacle in the management of advanced prostate cancer (PCa) is the occurrence of resistance to endocrine-therapy. Although the androgen receptor (AR) has been linked to therapy failure, the underlying escape mechanisms have not been fully clarified. Being closely related to the AR, the glucocorticoid receptor (GR) has been suggested to play a role in enzalutamide and docetaxel resistance. Given that glucocorticoids are frequently applied to PCa patients, it is essential to unravel the exact role of the GR in PCa progression...
November 20, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29156295/components-of-schizophrenia-liability-are-not-uniformly-associated-with-stress-sensitivity-resilience-and-coping
#14
Christian Ruzibiza, Rebecca E Grattan, Rebekah Eder, Richard J Linscott
Stress sensitization is a candidate final common pathway for the development of schizophrenia. In other psychopathologies, resilience attenuates the stressor-outcome relationships. Therefore, we sought to determine whether resilience moderates the association between stress sensitivity and schizophrenia liability. Undergraduates (n = 230) self-reported cognitive-perceptual, interpersonal, and disorganisation attributes of schizophrenia liability as well as ratings of sensitivity to stress, resilience, and dispositional coping behaviour...
November 14, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29151706/chebyshev-type-inequalities-by-means-of-copulas
#15
Sever S Dragomir, Eder Kikianty
A copula is a function which joins (or 'couples') a bivariate distribution function to its marginal (one-dimensional) distribution functions. In this paper, we obtain Chebyshev type inequalities by utilising copulas.
2017: Journal of Inequalities and Applications
https://www.readbyqxmd.com/read/29150404/stress-hormones-concentrations-in-the-normal-microenvironment-predict-risk-for-chemically-induced-cancer-in-rats
#16
Vitor Bonetti Valente, Flávia Alves Verza, Felipe Yudi Kabeya Lopes, Joana Zafalon Ferreira, Paulo Sérgio Patto Dos Santos, Maria Lúcia Marçal Mazza Sundefeld, Éder Ricardo Biasoli, Glauco Issamu Miyahara, Ana Maria Pires Soubhia, Mariza de Andrade, Sandra Helena Penha de Oliveira, Daniel Galera Bernabé
Evidence show that stress hormones can influence cancer progression, but its role in carcinogenesis is poorly understood. In this study, we used a new method based on oral carcinogenesis model in rats to test the hypothesis that physiological levels of stress hormones in the normal tissue microenvironment would have significant predictive value for chemically induced cancer occurrence. Male Wistar rats were submitted to a tongue biopsy for measuring not-stress induced levels of norepinephrine, corticosterone, adrenocorticotropic hormone (ACTH) and brain-derived neurotrophic factor (BDNF) in the tissue before carcinogenic induction...
November 8, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29144424/synthesis-characterization-and-biological-activities-of-biopolymeric-schiff-bases-prepared-with-chitosan-and-salicylaldehydes-and-their-pd-ii-and-pt-ii-complexes
#17
Hellen Franciane Gonçalves Barbosa, Maha Attjioui, Ana Paula Garcia Ferreira, Edward Ralph Dockal, Nour Eddine El Gueddari, Bruno M Moerschbacher, Éder Tadeu Gomes Cavalheiro
In an attempt to enhance chitosan biological activities, biopolymeric Schiff bases of chitosan and different salicylaldehydes and their palladium(II) and platinum(II) complexes were synthesized and tested. The chemical structures of these derivatives were characterized using ¹H-NMR, FTIR spectroscopy and XPRD. Thermal analysis was done through TGA/DTG-DTA. Electronic absorption spectra and surface morphologies were analyzed by SEM-EDAX. Chitosan and its derivatives were evaluated for their in vitro antimicrobial activity against two common bacterial and fungal plant pathogens Pseudomonas syringae pv...
November 16, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29143318/calcineurin-inhibitor-induced-complement-system-activation-via-erk1-2-signalling-is-inhibited-by-socs-3-in-human-renal-tubule-cells
#18
Beatrix Loeschenberger, Lea Niess, Reinhard Würzner, Hubert Schwelberger, Iris E Eder, Martin Puhr, Julia Guenther, Jakob Troppmair, Michael Rudnicki, Hannes Neuwirt
One factor that significantly contributes to renal allograft loss is chronic calcineurin inhibitor (CNI) nephrotoxicity (CIN). Among other factors, the complement (C-) system has been proposed to be involved CIN development. Hence, we investigated the impact of CNIs on intracellular signalling and the effects on the C-system in human renal tubule cells. In a qPCR array, CNI treatment upregulated C-factors and downregulated SOCS-3 and the complement inhibitors CD46 and CD55. Additionally, ERK1/-2 was required for these regulations...
November 15, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/29136792/comparative-performances-of-a-bare-graphite-polyurethane-composite-electrode-unmodified-and-modified-with-graphene-and-carbon-nanotubes-in-the-electrochemical-determination-of-escitalopram
#19
Marina Baccarin, Priscila Cervini, Eder Tadeu Gomes Cavalheiro
A bare composite graphite-polyurethane electrode (EGPU) and two other modified with graphene (EGPU-GR) and functionalized multi-walled carbon nanotubes (EGPU-CNTs) were prepared and compared regarding their voltammetric response to escitalopran (EST). The modifiers were characterized by Raman spectroscopy and the resulting electrode materials by contact angle measurements with a hydrophilicity character in the ascending order for the composites: GPU > GPU-GR > GPU-CNTs and scanning electron microscopy (SEM)...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29133101/antioxidant-antiproliferative-and-immunostimulatory-effects-of-cell-wall-%C3%AE-d-mannan-fractions-from-kluyveromyces-marxianus
#20
Éder Galinari, Jailma Almeida-Lima, Gorete Ribeiro Macedo, Hilário Cuquetto Mantovani, Hugo Alexandre Oliveira Rocha
This study evaluated the antioxidant, antiproliferative, and immunostimulatory properties of cell wall α-D-mannan fractions from yeast Kluyveromyces marxianus CCT7735. Filter centrifugation was used to obtain four fractions (KMM-1, KMM-2, KMM-3, and KMM-4) with molecular weight ranging from 7.6 to 75.1kDa. KMM-1 and KMM-2 comprised D-mannose with traces of D-glucose, whereas other fractions contained only D-mannose. Total sugar found in samples ranged from 85.9% to 96.1%, while protein and phenolic contents were 1...
November 10, 2017: International Journal of Biological Macromolecules
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