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https://www.readbyqxmd.com/read/28230754/green-hydroselenation-of-aryl-alkynes-divinyl-selenides-as-a-precursor-of-resveratrol
#1
Gelson Perin, Angelita M Barcellos, Eduardo Q Luz, Elton L Borges, Raquel G Jacob, Eder J Lenardão, Luca Sancineto, Claudio Santi
A simple and efficient protocol to prepare divinyl selenides has been developed by the regio- and stereoselective addition of sodium selenide species to aryl alkynes. The nucleophilic species was generates in situ, from the reaction of elemental selenium with NaBH₄, utilizing PEG-400 as the solvent. Several divinyl selenides were obtained in moderate to excellent yields with selectivity for the (Z,Z)-isomer by a one-step procedure that was carried out at 60 °C in short reaction times. The methodology was extended to tellurium, giving the desired divinyl tellurides in good yields...
February 20, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28229941/dual-high-resolution-inhibition-profiling-and-hplc-hrms-spe-nmr-analysis-for-identification-of-%C3%AE-glucosidase-and-radical-scavenging-inhibitors-in-solanum-americanum-mill
#2
Eder L Silva, Rita C Almeida-Lafetá, Ricardo M Borges, Dan Staerk
Solanum americanum is one of the most prominent species used to treat type 2 diabetes in Guatemala. In our ongoing efforts to find antidiabetic and antioxidative compounds from natural sources, an ethyl acetate extract of this medicinal herb was investigated using dual high-resolution α-glucosidase/radical scavenging inhibition profiling. The high-resolution biochromatograms obtained by this technique were used to target subsequent structural elucidation by HPLC-HRMS-SPE-NMR analysis towards the bioactive constituents...
February 13, 2017: Fitoterapia
https://www.readbyqxmd.com/read/28228429/two-faces-of-gamma-delta-mycosis-fungoides-before-and-after-renal-transplantation
#3
Knut Erich Prillinger, Franz Trautinger, Melitta Kitzwögerer, Johanna Eder
We describe a patient with a 30-year history of mycosis fungoides (MF) and renal transplantation performed 3 years before he presented with an ulcerated tumour in the lumbosacral area. Biopsy revealed a lymphatic infiltrate of medium-sized, pleomorphic T cells expressing the gamma-delta T-cell receptor. Radiological staging and bone marrow biopsy revealed no extracutaneous involvement. Despite reduction in systemic immunosuppressants, total skin electron beam radiotherapy and systemic chemotherapy, the disease followed a highly aggressive course and the patient died 31 years after initial diagnosis of MF...
February 22, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28222356/extinction-of-avoidance-behavior-by-safety-learning-depends-on-endocannabinoid-signaling-in-the-hippocampus
#4
Vincenzo Micale, Jens Stepan, Angela Jurik, Fabricio A Pamplona, Rudolph Marsch, Filippo Drago, Matthias Eder, Carsten T Wotjak
The development of exaggerated avoidance behavior is largely responsible for the decreased quality of life in patients suffering from anxiety disorders. Studies using animal models have contributed to the understanding of the neural mechanisms underlying the acquisition of avoidance responses. However, much less is known about its extinction. Here we provide evidence in mice that learning about the safety of an environment (i.e., safety learning) rather than repeated execution of the avoided response in absence of negative consequences (i...
February 3, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28215897/effects-of-body-condition-monensin-and-essential-oils-on-ruminal-lipopolysaccharide-concentration-inflammatory-markers-and-endoplasmatic-reticulum-stress-of-transition-dairy-cows
#5
C Drong, S Bühler, J Frahm, L Hüther, U Meyer, D von Soosten, D K Gessner, K Eder, H Sauerwein, S Dänicke
Evidence exists that dairy cows experience inflammatory-like phenomena in the transition period. Rumen health and alterations in metabolic processes and gene networks in the liver as the central metabolic organ might be key factors for cows' health and productivity in early lactation. This study made use of an animal model to generate experimental groups with different manifestations of postpartal fat mobilization and ketogenesis. In total, 60 German Holstein cows were allocated 6 wk antepartum to 3 high-body condition score (BCS) groups (BCS 3...
February 16, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28214432/degree-of-target-utilization-influences-the-location-of-movement-endpoint-distributions
#6
Andrew B Slifkin, Jeffrey R Eder
According to dominant theories of motor control, speed and accuracy are optimized when, on the average, movement endpoints are located at the target center and when the variability of the movement endpoint distributions is matched to the width of the target (viz., Meyer, Abrams, Kornblum, Wright & Smith, 1988). The current study tested those predictions. According to the speed-accuracy trade-off, expanding the range of variability to the amount permitted by the limits of the target boundaries allows for maximization of movement speed while centering the distribution on the target center prevents movement errors that would have occurred had the distribution been off center...
February 15, 2017: Acta Psychologica
https://www.readbyqxmd.com/read/28202737/the-association-between-obesity-and-clinical-features-of-psoriatic-arthritis-a-case-control-study
#7
Lihi Eder, Fatima Abji, Cheryl F Rosen, Vinod Chandran, Dafna D Gladman
OBJECTIVE: To assess whether obesity is associated with distinct psoriatic arthritis (PsA) features and whether it interacts with PsA HLA susceptibility alleles. METHODS: Patients with early PsA were compared with patients with psoriasis without arthritis (PsC). The primary predictor was the body mass index (BMI) at the first visit to the clinic. The clinical features across 3 BMI groups were compared by linear trend test and Cochrane-Armitage trend test. The interaction between BMI and HLA risk alleles for psoriatic disease (HLA-B*27, B*3901, B*3801, B*0801, B*4402, B*4403, and C*0602) were assessed using logistic regression analysis...
February 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28175247/p746-clinical-characteristic-of-crohn-s-disease-patients-in-polish-population
#8
M Lodyga, P Eder, M Gawron-Kiszka, M Hartleb, J Kierkus, M Klopocka, M Kukulska, K Linke, E Malecka-Panas, E Poniewierka, I Smola, T Rawa, J Regula, G Rydzewska
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28174169/altered-blood-flow-response-to-small-muscle-mass-exercise-in-cancer-survivors-treated-with-adjuvant-therapy
#9
Kaylin D Didier, Austin K Ederer, Landon K Reiter, Michael Brown, Rachel Hardy, Jacob Caldwell, Christopher Black, Michael G Bemben, Carl J Ade
BACKGROUND: Adjuvant cancer treatments have been shown to decrease cardiac function. In addition to changes in cardiovascular risk, there are several additional functional consequences including decreases in exercise capacity and increased incidence of cancer-related fatigue. However, the effects of adjuvant cancer treatment on peripheral vascular function during exercise in cancer survivors have not been well documented. We investigated the vascular responses to exercise in cancer survivors previously treated with adjuvant cancer therapies...
February 7, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28168303/pembrolizumab-as-first-line-therapy-for-patients-with-pd-l1-positive-advanced-non-small-cell-lung-cancer-a-phase-1-trial
#10
R Hui, E B Garon, J W Goldman, N B Leighl, M D Hellmann, A Patnaik, L Gandhi, J P Eder, M-J Ahn, L Horn, E Felip, E Carcereny, R Rangwala, G M Lubiniecki, J Zhang, K Emancipator, C Roach, N A Rizvi
No abstract text is available yet for this article.
February 7, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28154087/suppression-of-runx1-eto-oncogenic-activity-by-a-small-molecule-inhibitor-of-tetramerization
#11
Julia Schanda, Chun-Wei Lee, Katharina Wohlan, Uta Müller-Kuller, Hana Kunkel, Isabell Quagliano-Lo Coco, Stefan Stein, Alexander Metz, Joachim Koch, Jörn Lausen, Uwe Platzbecker, Hind Medyouf, Holger Gohlke, Michael Heuser, Matthias Eder, Manuel Grez, Michaela Scherr, Christian Wichmann
No abstract text is available yet for this article.
February 2, 2017: Haematologica
https://www.readbyqxmd.com/read/28148697/updating-the-psoriatic-arthritis-psa-core-domain-set-a-report-from-the-psa-workshop-at-omeract-2016
#12
Ana-Maria Orbai, Maarten de Wit, Philip J Mease, Kristina Callis Duffin, Musaab Elmamoun, William Tillett, Willemina Campbell, Oliver FitzGerald, Dafna D Gladman, Niti Goel, Laure Gossec, Pil Hoejgaard, Ying Ying Leung, Chris Lindsay, Vibeke Strand, Désirée M van der Heijde, Bev Shea, Robin Christensen, Laura Coates, Lihi Eder, Neil McHugh, Umut Kalyoncu, Ingrid Steinkoenig, Alexis Ogdie
OBJECTIVE: To include the patient perspective in accordance with the Outcome Measures in Rheumatology (OMERACT) Filter 2.0 in the updated Psoriatic Arthritis (PsA) Core Domain Set for randomized controlled trials (RCT) and longitudinal observational studies (LOS). METHODS: At OMERACT 2016, research conducted to update the PsA Core Domain Set was presented and discussed in breakout groups. The updated PsA Core Domain Set was voted on and endorsed by OMERACT participants...
February 1, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28148695/the-risk-of-developing-diabetes-mellitus-in-patients-with-psoriatic-arthritis-a-cohort-study
#13
Lihi Eder, Vinod Chandran, Richard Cook, Dafna D Gladman
OBJECTIVE: To estimate the prevalence of diabetes mellitus (DM) in patients with psoriatic arthritis (PsA) in comparison with the general population and to assess whether the level of disease activity over time predicts the development of DM in these patients. METHODS: A cohort analysis was conducted in patients followed in a large PsA clinic from 1978 to 2014. The prevalence of DM in the patients was compared with the general population of Ontario, Canada, and the age-standardized prevalence ratio (SPR) was calculated...
February 1, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28145936/a-rare-case-of-malignant-fibrous-histiocytoma-undifferentiated-high-grade-pleomorphic-sarcoma-of-malar-region
#14
Éder A Sigua-Rodriguez, Douglas Rangel Goulart, Afonso Celso de Moraes Manzano, Luciana Asprino
Malignant fibrous histiocytoma is a sarcoma with rare occurrence in the oral and maxillofacial region; surgery is the most reliable treatment. Inadequate resection of the sarcoma on the oral and maxillofacial region is associated with a high incidence of local recurrence and a poor prognosis. Only few patients of malignant fibrous histiocytoma of the malar region have been previously reported in the literature. The authors report a new patient of malignant fibrous histiocytoma on the right malar region that treated a complete tumor surgical excision without lymph node dissection...
January 31, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28145450/development-of-a-human-vasopressin-v1a-receptor-antagonist-from-an-evolutionary-related-insect-neuropeptide
#15
Maria Giulia Di Giglio, Markus Muttenthaler, Kasper Harpsøe, Zita Liutkeviciute, Peter Keov, Thomas Eder, Thomas Rattei, Sarah Arrowsmith, Susan Wray, Ales Marek, Tomas Elbert, Paul F Alewood, David E Gloriam, Christian W Gruber
Characterisation of G protein-coupled receptors (GPCR) relies on the availability of a toolbox of ligands that selectively modulate different functional states of the receptors. To uncover such molecules, we explored a unique strategy for ligand discovery that takes advantage of the evolutionary conservation of the 600-million-year-old oxytocin/vasopressin signalling system. We isolated the insect oxytocin/vasopressin orthologue inotocin from the black garden ant (Lasius niger), identified and cloned its cognate receptor and determined its pharmacological properties on the insect and human oxytocin/vasopressin receptors...
February 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28138398/comparative-analysis-of-morphological-and-molecular-motifs-in-bronchiolitis-obliterans-and-alveolar-fibroelastosis-after-lung-and-stem-cell-transplantation
#16
Danny Jonigk, Berenice Rath, Paul Borchert, Peter Braubach, Lavinia Maegel, Nicole Izykowski, Gregor Warnecke, Wiebke Sommer, Hans Kreipe, Robert Blach, Adrian Anklamm, Axel Haverich, Matthias Eder, Michael Stadler, Tobias Welte, Jens Gottlieb, Mark Kuehnel, Florian Laenger
Chronic lung allograft dysfunction (CLAD) remains the major obstacle to long-term survival following lung transplantation (LuTx). Morphologically CLAD is defined by obliterative remodelling of the small airways (bronchiolitis obliterans, BO) as well as a more recently described collagenous obliteration of alveoli with elastosis summarised as alveolar fibroelastosis (AFE). Both patterns are not restricted to pulmonary allografts, but have also been reported following haematopoietic stem cell transplantation (HSCT) and radio chemotherapy (RC)...
January 2017: Journal of Pathology. Clinical Research
https://www.readbyqxmd.com/read/28135636/phasic-valence-and-arousal-do-not-influence-post-conflict-adjustments-in-the-simon-task
#17
David Dignath, Markus Janczyk, Andreas B Eder
According to theoretical accounts of cognitive control, conflict between competing responses is monitored and triggers post conflict behavioural adjustments. Some models proposed that conflict is detected as an affective signal. While the conflict monitoring theory assumed that conflict is registered as a negative valence signal, the adaptation by binding model hypothesized that conflict provides a high arousal signal. The present research induced phasic affect in a Simon task with presentations of pleasant and unpleasant pictures that were high or low in arousal...
January 27, 2017: Acta Psychologica
https://www.readbyqxmd.com/read/28133703/erratum-to-toward-establishing-a-morphological-and-ultrastructural-characterization-of-proembryogenic-masses-and-early-somatic-embryos-of-araucaria-angustifolia-bert-o-kuntze
#18
Neusa Steiner, Francine L Farias-Soares, Éder C Schmidt, Maria L T Pereira, Bruna Scheid, Gladys D Rogge-Renner, Zenilda L Bouzon, Daniela Schmitz, Sara Maldonado, Miguel P Guerra
No abstract text is available yet for this article.
January 30, 2017: Protoplasma
https://www.readbyqxmd.com/read/28131581/different-milk-feeding-intensities-during-the-first-4-weeks-of-rearing-dairy-calves-part-2-effects-on-the-metabolic-and-endocrine-status-during-calfhood-and-around-the-first-lactation
#19
J Kesser, M Korst, C Koch, F-J Romberg, J Rehage, U Müller, M Schmicke, K Eder, H M Hammon, H Sadri, H Sauerwein
Feeding dairy calves at high intensity has been demonstrated to increase milk yield in later life. We investigated the effect of 3 different feeding regimens in the preweaning period on the metabolic and endocrine status during calfhood and in heifers at the onset of the first lactation. In trial 1, 57 German Holstein calves were allocated to 3 different feeding groups: milk replacer restricted to 6.78 kg/calf per day, 11.5% solids (MR-res, n = 20), milk replacer 13.8% solids, ad libitum (MR-ad lib, n = 17), and whole milk ad libitum (WM-ad lib, n = 20)...
January 25, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28131579/different-milk-feeding-intensities-during-the-first-4-weeks-of-rearing-in-dairy-calves-part-1-effects-on-performance-and-production-from-birth-over-the-first-lactation
#20
M Korst, C Koch, J Kesser, U Müller, F-J Romberg, J Rehage, K Eder, H Sauerwein
We aimed to test the effects of ad libitum feeding of whole milk (WM) or milk replacer (MR) versus restrictive feeding of MR during the first 4 wk of life on growth performance and on milk yield in the first lactation. We studied 57 German Holstein calves (29 females, 28 males) from birth until d 110 of life (trial 1). The 28 females from trial 1 were further studied during their first lactation (trial 2). In trial 1, all calves were randomly allocated at birth to 1 of 3 groups: MR-res [n = 20, 6.78 kg MR (11...
January 25, 2017: Journal of Dairy Science
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