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Vera Kadlecek, Charissa Fay Borja-Tabora, Susanne Eder-Lingelbach, Salvacion Gatchalian, Sigrid Kiermayr, Benjamin Sablan, Michael Kundi, Christian Taucher, Katrin L Dubischar
BACKGROUND: An inactivated Vero cell culture derived Japanese encephalitis virus vaccine (IXIARO) requires a booster dose 1 year after primary schedule for long-term antibody persistence in adults. OBJECTIVES: To evaluate immunogenicity and safety of a booster dose in children aged 2 months to <18 years. METHODS: A randomized, controlled open-label study in the Philippines. Three hundred children vaccinated with IXIARO in a previous trial were randomized 1:1 to receive either no booster or a booster 12 months after initiation of the primary series...
June 15, 2018: Pediatric Infectious Disease Journal
Eduardo López-Medina, Beatriz Parra, Diana M Dávalos, Pio López, Eder Villamarín, Melissa Pelaez
BACKGROUND: In Latin America, there is little epidemiological data resulting from highly sensitive molecular techniques for the study of acute gastroenteritis (AGE) in the post-rotavirus vaccine era. METHODS: Prospective surveillance was performed between March 15, 2015 to March 19, 2016 in two Municipal Health Networks (MHN) from Cali, Colombia to detect AGE in children <5years. Consecutive sampling was performed simultaneously in all health facilities belonging to both MHN until completion of the required sample size...
June 14, 2018: International Journal of Infectious Diseases: IJID
C Büchner, S D Eder, T Nesse, D Kuhness, P Schlexer, G Pacchioni, J R Manson, M Heyde, B Holst, H-J Freund
A chemically stable bilayers of SiO_{2} (2D silica) is a new, wide band gap 2D material. Up till now graphene has been the only 2D material where the bending rigidity has been measured. Here we present inelastic helium atom scattering data from 2D silica on Ru(0001) and extract the first bending rigidity, κ, measurements for a nonmonoatomic 2D material of definable thickness. We find a value of κ=8.8  eV±0.5  eV which is of the same order of magnitude as theoretical values in the literature for freestanding crystalline 2D silica...
June 1, 2018: Physical Review Letters
Michael Eder, Christoph Schwarz, Michael Kammer, Niels Jacobsen, Stavroula Masouridi Levrat, Morton J Cowan, Tepsiri Chongkrairatanakul, Robert Gaston, Rommel Ravanan, Hideki Ishida, Anette Bachmann, Sergio Alvarez, Martina Koch, Cyril Garrouste, Ulrich A Duffner, Brett Cullis, Nicolaas Schaap, Michael Medinger, Søren Schwartz Sørensen, Eva-Maria Dauber, Georg Böhmig, Heinz Regele, Gabriela A Berlakovich, Thomas Wekerle, Rainer Oberbauer
Tolerance induction through simultaneous hematopoietic stem cell- and renal transplantation has shown promising results, but it is hampered by the toxicity of preconditioning therapies and graft-versus-host disease. Moreover, renal function has never been compared to conventionally transplanted patients, thus, whether donor-specific tolerance results in improved outcomes remains unanswered. We collected follow-up data of published cases of renal transplantations after hematopoietic stem cell transplantation from the same donor and compared patient- and transplant kidney survival- as well as function with caliper-matched living-donor renal transplantations from the Austrian dialysis and transplant registry...
June 13, 2018: American Journal of Transplantation
Milessa Silva Afonso, Roberta Marcondes Machado, Maria Silvia Ferrari Lavrador, Eder Carlos Rocha Quintao, Kathryn J Moore, Ana Maria Lottenberg
Cholesterol is an essential molecule that exerts pleiotropic actions. Although its presence is vital to the cell, its excess can be harmful and, therefore, sustaining cholesterol homeostasis is crucial to maintaining proper cellular functioning. It is well documented that high plasma cholesterol concentration increases the risk of atherosclerotic heart disease. In the last decades, several studies have investigated the association of plasma cholesterol concentrations and the risk of cardiovascular diseases as well as the signaling pathways involved in cholesterol homeostasis...
June 13, 2018: Nutrients
Peter Wallner, Michael Kundi, Arne Arnberger, Renate Eder, Brigitte Allex, Lisbeth Weitensfelder, Hans-Peter Hutter
Cognitive functioning and academic performance of pupils depend on regular breaks from classroom work. However, it is unclear which settings during such breaks provide the best environment to restore cognitive performance and promote wellbeing of adolescent pupils. Therefore, we investigated the effects of staying in different urban green spaces during breaks. Sixty-four pupils (16⁻18 years old) participated in a cross-over experiment. They were placed into one of three settings (small park, larger park, forest) for one hour during a lunch break...
June 8, 2018: International Journal of Environmental Research and Public Health
Simone Pellegrino, Natalia Demeshkina, Eder Mancera-Martinez, Sergey Melnikov, Angelita Simonetti, Alexander Myasnikov, Marat Yusupov, Gulnara Yusupova, Yaser Hashem
One of the most critical steps of protein biosynthesis is the coupled movement of messenger RNA (mRNA), that encodes genetic information, with transfer RNAs (tRNAs) on the ribosome. In eukaryotes this process is catalyzed by a conserved G-protein, the elongation factor 2 (eEF2), which carries a unique post-translational modification, called diphthamide, found in all eukaryotic species. Here we present near-atomic resolution cryo-EM structures of yeast 80S ribosome complexes containing mRNA, tRNA and eEF2 trapped in different GTP-hydrolysis states which provide further structural insights on the role of diphthamide in the mechanism of translation fidelity in eukaryotes...
June 7, 2018: Journal of Molecular Biology
Mariene R Cunha, Eder C Lima, Nilton F G M Cimirro, Pascal S Thue, Silvio L P Dias, Marcos A Gelesky, Guilherme L Dotto, Glaydson S Dos Reis, Flávio A Pavan
Eragrostis plana Nees leaves, abundant lignocellulosic biomass, was used as carbon source for preparation of activated carbon, by using microwave-assisted pyrolysis and chemical activation. The novel activated carbon (MWEPN) was characterised by FTIR, CHN elemental analysis, Boehm's titration method, TGA, SEM, N2 adsorption/desorption curves and pH of the point of zero charge (pHpzc ). Afterwards, the adsorbent was successfully employed for adsorption of the two emerging contaminants (caffeine and 2-nitrophenol)...
June 5, 2018: Environmental Science and Pollution Research International
Éder C Lanes, Nathaniel S Pope, Ronnie Alves, Nelson M Carvalho Filho, Tereza C Giannini, Ana M Giulietti, Vera L Imperatriz-Fonseca, Waléria Monteiro, Guilherme Oliveira, Amanda R Silva, José O Siqueira, Pedro W Souza-Filho, Santelmo Vasconcelos, Rodolfo Jaffé
Although genetic diversity ultimately determines the ability of organisms to adapt to environmental changes, conservation assessments like the widely used International Union for Conservation of Nature (IUCN) Red List Criteria do not explicitly consider genetic information. Including a genetic dimension into the IUCN Red List Criteria would greatly enhance conservation efforts, because the demographic parameters traditionally considered are poor predictors of the evolutionary resilience of natural populations to global change...
2018: Frontiers in Plant Science
Emir Salas-Sarduy, Lionel Urán Landaburu, Joel Karpiak, Kevin P Madauss, Juan José Cazzulo, Fernán Agüero, Vanina Eder Alvarez
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
June 4, 2018: Scientific Reports
R Flatabø, S D Eder, A K Ravn, B Samelin, M M Greve, T Reisinger, B Holst
In neutral helium atom microscopy, a beam of atoms is scanned across a surface. Though still in its infancy, neutral helium microscopy has seen a rapid development over the last few years. The inertness and low energy of the helium atoms (less than 0.1 eV) combined with a very large depth of field and the fact that the helium atoms do not penetrate any solid material at low energies open the possibility for a non-destructive instrument that can measure topology on the nanoscale even on fragile and insulating surfaces...
May 2018: Review of Scientific Instruments
Elisabeth Anne-Sophie Mayrhuber, Michel L A Dückers, Peter Wallner, Arne Arnberger, Brigitte Allex, Laura Wiesböck, Anna Wanka, Franz Kolland, Renate Eder, Hans-Peter Hutter, Ruth Kutalek
BACKGROUND: Heatwaves form a serious public health threat, especially for vulnerable groups. Interventions such as active outreach programs, exposure reduction measures and monitoring and mapping of at-risk groups are increasingly implemented across the world but little is known about their effect. OBJECTIVES: To assess how vulnerable groups are identified and reached in heat health interventions, to understand the effectiveness and efficiency of those interventions, and to identify research gaps in existing literature...
May 31, 2018: Environmental Research
Patrícia da Silva Pantoja, Ana Maria Sampaio Assreuy, Renan Oliveira Silva, Samara Rodrigues Bonfim Damasceno, Vanessa Azevedo Mendonça, Tiago Santos Mendes, Jose Athayde Vasconcelos Morais, Samira Lopes de Almeida, Antônio Éder Enzo Albuquerque Teixeira, Marcellus Henrique Loiola Ponte de Souza, Maria Gonçalves Pereira, Pedro Marcos Gomes Soares
ETHNOPHARMACOLOGICAL RELEVANCE: Barks of Ximenia americana are used by the population to treat gastrointestinal inflammatory disorders. Indomethacin is a non-selective non-steroidal anti-inflammatory drug that induces marked gastrointestinal damage. AIMS OF THE STUDIES: To evaluate the gastroprotective activity of total polysaccharides contained in the extract (TPL-Xa) or tea (Tea-Xa) of Ximenia americana barks in the mice gastric damage induced by indomethacin...
May 30, 2018: Journal of Ethnopharmacology
Lihi Eder, Sibel Z Aydin, Gurjit S Kaeley, Walter P Maksymowych, Mikkel Østergaard
Psoriatic arthritis (PsA) is a heterogeneous disease with various manifestations of musculoskeletal inflammation. Recent advances in imaging, including ultrasound (US) and magnetic resonance imaging (MRI), allow for the accurate evaluation of the extent of inflammation and damage in the peripheral joints, spine, and entheses. The development and validation of outcome measures are critical steps in creating standardized evaluations of musculoskeletal inflammation and damage in psoriatic patients. At the 2017 meeting of the Group for Research and Assessment of Psoriasis and PsA (GRAPPA), recent work on outcome measures from the GRAPPA US and MRI working groups was summarized...
June 2018: Journal of Rheumatology. Supplement
Richard Holland, William Tillett, Alexis Ogdie, Ying Y Leung, Dafna D Gladman, Kristina Callis Duffin, Laura C Coates, Philip J Mease, Lihi Eder, Vibeke Strand, Musaab Elmamoun, Pil Højgaard, Jeffrey Chau, Maarten de Wit, Niti Goel, Chris A Lindsay, Oliver FitzGerald, Bev Shea, Dorcas Beaton, Ana-Maria Orbai
The Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA)-Outcome Measures in Rheumatology (OMERACT) Psoriatic Arthritis (PsA) Core Set working group is in the process of selecting core instruments for PsA clinical trials. During a 2-h workshop and breakout group discussions at the GRAPPA 2017 annual meeting in Amsterdam, the Netherlands, participants discussed the first set of candidate instruments to be taken through the OMERACT Filter 2.1 instrument selection process: 66/68 swollen/tender joint count (66/68JC), Spondyloarthritis Consortium of Canada (SPARCC) enthesitis index, patient's global assessment (GRAPPA and OMERACT formulations), Health Assessment Questionnaire-Disability Index (HAQ-DI), Psoriatic Arthritis Impact of Disease (PsAID) questionnaires 9 and 12, and Functional Assessment of Chronic Illness Therapy (FACIT) Fatigue...
June 2018: Journal of Rheumatology. Supplement
Cintia Barcelos, Felipe Damas, Sanmy Rocha Nóbrega, Carlos Ugrinowitsch, Manoel Emílio Lixandrão, Lucas Marcelino Eder Dos Santos, Cleiton Augusto Libardi
The aim of the study was to compare the effect of resistance training (RT) frequencies of five times (RT5), thrice- (RT3) or twice- (RT2) weekly in muscle strength and hypertrophy in young men. Were used a within-subjects design in which 20 participants had one leg randomly assigned to RT5 and the other to RT3 or to RT2. 1 RM and muscle cross-sectional area (CSA) were assessed at baseline, after four (W4) and eight (W8) RT weeks. RT5 resulted in greater total training volume (TTV) than RT3 and RT2 (P = ...
May 31, 2018: European Journal of Sport Science
Antonio Dionízio De Albuquerque Neto, André Vitor Alves Araújo, Daniel Assunção Cerqueira, Lorenzzo De Angeli Cesconetto, Nilton Provenzano, Eder Magno Ferreira de Oliveira
Paracoccidioidomycosis is a fungal infection initially described in Brazil in 1908 by Adolfo Lutz. Manifestation of this disease depends on numerous factors, such as microorganism virulence, hormonal profile, genetic predisposition, nutrition, and immune system. It is characterized classically by cutaneous lesions, lymphadenopathy, and pulmonary involvement. It presents male predilection, which can be explained by the protective effect of female hormones. Classic presentation within oral cavity is a superficial ulcer characterized by hemorrhagic dots of moriform aspect...
2018: Case Reports in Otolaryngology
Tinna Traustadóttir, S Mitchell Harman, Panayiotis Tsitouras, Karol M Pencina, Zhuoying Li, Thomas G Travison, Richard Eder, Renee Miciek, Jennifer McKinnon, Erin Woodbury, Shehzad Basaria, Shalender Bhasin, Thomas W Storer
Context: Testosterone increases skeletal muscle mass and strength, but long-term effects of testosterone supplementation on aerobic capacity (V˙O2peak) in healthy older men with low testosterone have not been evaluated. Objective: To determine the effects of testosterone supplementation on V˙O2peak during incremental cycle ergometry. Design: Testosterone's Effects on Atherosclerosis Progression in Aging Men trial: double-blind, randomized, placebo-controlled, parallel-group trial...
May 25, 2018: Journal of Clinical Endocrinology and Metabolism
Jung-Yun Lee, Sunghoon Kim, Young Tae Kim, Myong Cheol Lim, Boram Lee, Kyu-Won Jung, Jae Weon Kim, Sang-Yoon Park, Young-Joo Won
BACKGROUND: The survival of patients with ovarian cancer has improved because of surgery and chemotherapy. This study aimed to estimate the changes in survival rates among Korean women with ovarian cancer prior to the introduction of targeted therapy for ovarian cancer. METHODS: Data were obtained from the Korea Central Cancer Registry regarding patients who were diagnosed with epithelial ovarian cancer between 1995 and 2014. The relative survival rates were calculated for 5-year periods using the Ederer II method...
May 29, 2018: BMC Cancer
Ricardo M Borges, Rahil Taujale, Juliana Santana de Souza, Thaís de Andrade Bezerra, Eder Lana E Silva, Ronny Herzog, Francesca V Ponce, Jean-Luc Wolfender, Arthur S Edison
INTRODUCTION: Dereplication, an approach to sidestep the efforts involved in the isolation of known compounds, is generally accepted as being the first stage of novel discoveries in natural product research. It is based on metabolite profiling analysis of complex natural extracts. OBJECTIVE: To present the application of LipidXplorer for automatic targeted dereplication of phenolics in plant crude extracts based on direct infusion high-resolution tandem mass spectrometry data...
May 29, 2018: Phytochemical Analysis: PCA
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