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https://www.readbyqxmd.com/read/28448166/changes-in-motorcycle-related-injuries-and-deaths-after-mandatory-motorcycle-helmet-law-in-a-district-of-vietnam
#1
Ninh Thi Ha, David Ederer, Van Anh Vo Ha, An Van Pham, Anthony Mounts, Leisha Nolen, David Sugerman
OBJECTIVE: Our study measured the change in head injuries and deaths among motorcycle users in Cu Chi district, a suburban district of Ho Chi Minh City. METHODS: Hospital records for road traffic injuries (RTI) were collected from the Cu Chi Trauma Centre and motorcycle-related death records were obtained from mortality registries in commune health offices. Head injury severity was categorised using the Abbreviated Injury Score (AIS). Rate ratios (RR) were used to compare rates pre- and post-law (2005/06-2009/10)...
April 27, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28447893/ultra-small-solid-archaeolipid-nanoparticles-for-active-targeting-to-macrophages-of-the-inflamed-mucosa
#2
Leticia Herminia Higa, Horacio Emanuel Jerez, Marcelo Alexandre de Farias, Rodrigo Villares Portugal, Eder Lilia Romero, Maria Jose Morilla
AIM: Develop nanoparticulate agents for oral targeted delivery of dexamethasone (Dex) to macrophages of inflamed mucosa. MATERIALS & METHODS: Solid archaeolipid nanoparticles (SAN-Dex) (compritol/Halorubrum tebenquichense polar archaeolipids/soybean phosphatidylcholine/Tween-80 4; 0.9; 0.3; 3% w/w) loaded with Dex were prepared. Their mucopenetration, stability under digestion and in vitro anti-inflammatory activity, were determined. RESULTS: Ultra-small SAN-Dex strongly reduced the levels of TNF-α, IL-6 and IL-12 on J774A1 cells stimulated with lipopolysaccharides as compared with free Dex or loaded in ordinary solid lipid nanoparticles-Dex...
April 27, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28445060/asymmetric-synthesis-of-carbocyclic-propellanes
#3
Lisa M Schneider, Volker M Schmiedel, Tommaso Pecchioli, Dieter Lentz, Christian Merten, Mathias Christmann
A modular synthesis of functionalized carbocyclic propellanes was developed. Formation of the first of two quaternary bridgehead centers has been achieved by desymmetrization of prostereogenic ketones by either Hajos-Parrish-Eder-Sauer-Wiechert-type processes or Werner's catalytic asymmetric Wittig reaction. The obtained bicyclic enones were subjected to conjugate additions upon which the remaining ring was formed by olefin metathesis. All bridges are amenable to further derivatization, which renders those compounds useful as central units in fragment-based drug discovery or as ligand scaffolds...
April 26, 2017: Organic Letters
https://www.readbyqxmd.com/read/28443387/microwave-activated-carbons-from-tucum%C3%A3-astrocaryum-aculeatum-seed-for-efficient-removal-of-2-nitrophenol-from-aqueous-solutions
#4
Cibele S Umpierres, Pascal S Thue, Eder C Lima, Glaydson S Dos Reis, Irineu A S de Brum, Wagner S de Alencar, Silvio L P Dias, Guilherme L Dotto
Activated carbons (ACs) prepared from tucumã seed (Astrocaryum aculeatum) were used for 2-nitrophenol removal from aqueous solutions. The activated carbons were characterized by elemental analysis, FTIR, N2 adsorption/desorption isotherms, TGA, hydrophobicity/hydrophilicity balance, and total of acidic and basic groups. The ACs showed to have hydrophilic surfaces and they presented high specific surface areas (up to 1318 m(2)g(-1)). In batch optimization studies, maximum removal was obtained at pH 7, contact time of 30 min, adsorbent dosage 1...
April 26, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28441266/safety-of-the-inactivated-japanese-encephalitis-virus-vaccine-ixiaro%C3%A2-in-children-an-open-label-randomized-active-controlled-phase-3-study
#5
Katrin L Dubischar, Vera Kadlecek, Benjamin Sablan, Charissa Fay Borja-Tabora, Salvacion Gatchalian, Susanne Eder-Lingelbach, Zsuzsanna Mueller, Kerstin Westritschnig
BACKGROUND: Japanese encephalitis (JE) remains a serious health concern in Asian countries and has sporadically affected pediatric travelers. In the present study we monitored the safety profile of the JE virus (JEV) vaccine IXIARO in a pediatric population. METHODS: We randomized 1869 children between the age of 2 months and 17 years in an age-stratified manner to vaccination with IXIARO or one of the control vaccines, Prevnar and HAVRIX 720. Adverse events (AEs) (unsolicited and solicited local and systemic adverse events), serious AEs and medically-attended AEs were assessed up to Day 56 and Month 7 after the first dose...
April 24, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28438219/adverse-drug-reactions-and-kinetics-of-cisplatin-excretion-in-urine-of-patients-undergoing-cisplatin-chemotherapy-and-radiotherapy-for-head-and-neck-cancer-a-prospective-study
#6
Marília Berlofa Visacri, Eder de Carvalho Pincinato, Graziele Baldan Ferrari, Júlia Coelho França Quintanilha, Priscila Gava Mazzola, Carmen Silvia Passos Lima, Patricia Moriel
BACKGROUND: Cisplatin is a high-potency anticancer agent; however, it causes significant adverse drug reactions (ADRs). Potential pharmacokinetic markers must be studied to predict or prevent cisplatin-induced ADRs and achieve better prognosis. This study was designed to investigate the relationship between ADRs and kinetics of cisplatin excretion in the urine of patients undergoing high-dose cisplatin chemotherapy and radiotherapy for head and neck cancer. METHODS: Outpatients with head and neck cancer received a first cycle of high-dose cisplatin chemotherapy (80-100 mg/m(2)) concurrent to radiotherapy...
April 24, 2017: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/28430748/immunogenicity-of-the-inactivated-japanese-encephalitis-virus-vaccine-ixiaro%C3%A2-n-children-from-a-japanese-encephalitis-virus-endemic-region
#7
Katrin L Dubischar, Vera Kadlecek, Benjamin Sablan, Charissa Fay Borja-Tabora, Salvacion Gatchalian, Susanne Eder-Lingelbach, Sigrid Kiermayr, Martin Spruth, Kerstin Westritschnig
BACKGROUND: Japanese encephalitis (JE) is a major public health concern in Asia and poses a small, but potentially fatal threat to travelers from non-endemic countries, including children. No JE vaccine for pediatric use has been available in Europe and the USA. METHODS: Age-stratified cohorts of children between 2 months and 17 years received 2 doses of Vero cell-derived inactivated JE virus vaccine (IXIARO) administered 28 days apart (<3 years 0.25 mL [half adult dose], ≥3 years 0...
April 19, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28424672/isolation-and-identification-of-the-indigenous-yeast-population-during-spontaneous-fermentation-of-isabella-vitis-labrusca-l-grape-must
#8
María L Raymond Eder, Cristina Reynoso, Santiago C Lauret, Alberto L Rosa
Grape must harbors a complex community of yeast species responsible for spontaneous alcoholic fermentation. Although there are detailed studies on the microbiota of Vitis vinifera L. grapes, less is known about the diversity and behavior of yeast communities present on fermenting grape must from other species of Vitis. In this work, we used a culture-dependent method to study the identity and dynamics of the indigenous yeast population present during the spontaneous fermentation of Isabella (Vitis labrusca L...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28419366/effect-of-methionine-supplementation-in-chicken-feed-on-the-quality-and-shelf-life-of-fresh-poultry-meat
#9
Antonia Albrecht, Ulrike Herbert, Dennis Miskel, Celine Heinemann, Carina Braun, Sophia Dohlen, Johanna O Zeitz, Klaus Eder, Behnam Saremi, Judith Kreyenschmidt
The aim of this study was to investigate the influence of different methionine sources and concentrations on the quality and spoilage process of broiler meat. The trial was comprised of 7 treatment groups: one basal group (suboptimal in Methionine+Cysteine; i.e., 0.89, 0.74, 0.69% in DM SID Met+Cys in starter, grower, and finisher diets, respectively) and 3 doses (0.10, 0.25, and 0.40%) of either DL-Methionine (DLM) or DL-2-hydroxy-4-methylthio butanoic acid (DL-HMTBA) on an equimolar basis of the DLM-supplemented groups...
April 17, 2017: Poultry Science
https://www.readbyqxmd.com/read/28416560/horizontal-schools-based-health-programme-in-rural-kenya
#10
James Bogie, Ben Eder, Dan Magnus, Onguko David Amonje, Martina Gant
BACKGROUND: Primary school children in low-income countries are at risk of many diseases and poor health affects attendance, cognition and ability to learn. Developing school health and nutrition strategies has been extensively highlighted as a global priority, with a particular focus on complex programme design. However, such programmes are relatively untested in low-income settings. METHOD: We implemented a complex school health and nutrition programme in two schools in Western Kenya over 3 years...
April 17, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28411858/corrigendum-to-different-milk-feeding-intensities-during-the-first-4-weeks-of-rearing-dairy-calves-part-2-effects-on-the-metabolic-and-endocrine-status-during-calfhood-and-around-the-first-lactation-j-dairy-sci-100-3109-3125
#11
J Kesser, M Korst, C Koch, F-J Romberg, J Rehage, U Müller, M Schmicke, K Eder, H M Hammon, H Sadri, H Sauerwein
No abstract text is available yet for this article.
May 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28402990/the-use-of-gmp-produced-bone-marrow-derived-stem-cells-in-combination-with-extra-corporeal-membrane-oxygenation-in-ards-an-animal-model
#12
Ergin Kocyildirim, Nayra Cárdenes, Antony Ting, Eder Cáceres, Christian Bermúdez, Mauricio Rojas
RDS is the result of a wide variety of disorders, which can be associated with different clinical disorders or systemic diseases directly affecting the lungs. Currently, the only existing therapy is limited to supportive care. In a 6-hour pilot study, we analyzed the use of the combination of both stem cell and ECMO strategies to prevent or treat severe lung injury. A total of 11 sheep were used. 5 sheep received E. coli endotoxin as a control group (Group 1). 3 sheep that received E. coli endotoxin were treated with veno-venous ECMO support in Group 2...
April 11, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28396899/bcl2%C3%A2-genotypes-and-prostate-cancer-survival
#13
Wilfried Renner, Uwe Langsenlehner, Sabine Krenn-Pilko, Petra Eder, Tanja Langsenlehner
PURPOSE: The antiapoptotic B‑cell lymphoma 2 (BCL2) gene is a key player in cancer development and progression. A functional single-nucleotide polymorphism (c.-938C>A, rs2279115) in the inhibitory P2 BCL2 gene promoter has been associated with clinical outcomes in various types of cancer. Aim of the present study was to analyze the role of BCL2-938C>A genotypes in prostate cancer mortality. METHODS: The association between BCL2-938C>A (rs2279115) genotypes and prostate cancer outcome was studied within the prospective PROCAGENE study comprising 702 prostate cancer patients...
April 10, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28395820/characterization-and-quantification-of-fruit-phenolic-compounds-of-european-and-tunisian-pear-cultivars
#14
Marwa Brahem, Catherine M G C Renard, Severin Eder, Michèle Loonis, Rim Ouni, Messaoud Mars, Carine Le Bourvellec
The flesh and peel of 19 pear cultivars (8 Tunisian dessert cultivars, 8 European dessert cultivars and 3 French perry pear cultivars) were studied for their phenolic composition. Phenolic compounds were identified by HPLC/ESI-MS(2) and individually quantified by HPLC-DAD. Five classes of polyphenols were present: flavan-3-ols, phenolic acids, flavonols, anthocyanins and simple phenolics (hydroquinones). The total phenolic content ranged between 0.1g/kg Fresh Weight (FW) ('Conference' cultivar) and 8.6g/kg FW ('Plant De Blanc' cultivar) in the flesh and between 1...
May 2017: Food Research International
https://www.readbyqxmd.com/read/28391505/bacterial-communities-on-facial-skin-of-teenage-and-elderly-thai-females
#15
Naraporn Somboonna, Alisa Wilantho, Chutika Srisuttiyakorn, Anunchai Assawamakin, Sissades Tongsima
The Human Microbiome Project was first established to understand the roles of human-associated microbes to human health and disease. This study presents preliminary findings of Thai female facial skin microbiome using three pooled samples from groups of skin microbiome profiles, namely (1) healthy and (2) acne-prone young adults (teenage.hea and teenage.acn) and (3) healthy elderly adults (elderly.hea) based on standard dermatological criteria. These samples were sequenced using 454-pyrosequencing targeting 16S rRNA (V3-V4 regions)...
April 8, 2017: Archives of Microbiology
https://www.readbyqxmd.com/read/28389256/impact-of-molecular-genetics-on-outcome-in-myelofibrosis-patients-after-allogeneic-stem-cell-transplantation
#16
Nicolaus Kröger, Victoria Panagiota, Anita Badbaran, Tatjana Zabelina, Ioanna Triviai, Michelle Maria Araujo Cruz, Rabia Shahswar, Francis Ayuk, Marten Gehlhaar, Christine Wolschke, Robin Bollin, Carolin Walter, Martin Dugas, Lutz Wiehlmann, Ulrich Lehmann, Christian Koenecke, Anuhar Chaturvedi, Haefaa Alchalby, Michael Stadler, Matthias Eder, Max Christopeit, Gudrun Göhring, Michael Koenigsmann, Brigitte Schlegelberger, Hans-Heinrich Kreipe, Arnold Ganser, Carol Stocking, Boris Fehse, Felicitas Thol, Michael Heuser
Molecular genetics may influence outcome for patients with myelofibrosis. To determine the impact of molecular genetics on outcome after allogeneic stem cell transplantation, we screened 169 patients with primary myelofibrosis (n = 110), post-ET/PV myelofibrosis (n = 46), and myelofibrosis in transformation (n = 13) for mutations in 16 frequently mutated genes. The most frequent mutation was JAK2V617F (n = 101) followed by ASXL1 (n = 49), calreticulin (n = 34), SRSF2 (n = 16), TET2 (n = 10), U2AF1 (n = 11), EZH2 (n = 7), MPL (n = 6), IDH2 (n = 5), IDH1 (n = 4), and CBL (n = 1)...
April 4, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28387928/efficacy-and-feasibility-of-sorafenib-as-a-maintenance-agent-after-allogeneic-hematopoietic-stem-cell-transplantation-for-fms-like-tyrosine-kinase-3-mutated-acute-myeloid-leukemia
#17
Giorgia Battipaglia, Annalisa Ruggeri, Radwan Massoud, Jean El Cheikh, Matthieu Jestin, Ahmad Antar, Syed Osman Ahmed, Walid Rasheed, Marwan Shaheen, Ramdane Belhocine, Eolia Brissot, Remy Dulery, Sandra Eder, Federica Giannotti, Francoise Isnard, Simona Lapusan, Marie-Therese Rubio, Anne Vekhoff, Mahmoud Aljurf, Ollivier Legrand, Mohamad Mohty, Ali Bazarbachi
BACKGROUND: Sorafenib has shown encouraging results in patients with Fms-like tyrosine kinase 3 (FLT3)-positive acute myeloid leukemia. Its role after allogeneic stem cell transplantation (HSCT) has been reported in a few cases with encouraging results. METHODS: The authors describe the use of sorafenib as a maintenance agent after HSCT in 27 patients with FLT3-positive acute myeloid leukemia. RESULTS: The median age of the patients was 46 years (range, 15-57 years)...
April 7, 2017: Cancer
https://www.readbyqxmd.com/read/28380303/conception-and-implementation-of-an-austrian-biobank-directory-integration-framework
#18
Philipp Hofer-Picout, Horst Pichler, Johann Eder, Sabrina B Neururer, Heimo Müller, Robert Reihs, Petr Holub, Thomas Insam, Georg Goebel
INTRODUCTION: Sample collections and data are hosted within different biobanks at diverse institutions across Europe. Our data integration framework aims at incorporating data about sample collections from different biobanks into a common research infrastructure, facilitating researchers' abilities to obtain high-quality samples to conduct their research. The resulting information must be locally gathered and distributed to searchable higher level information biobank directories to maximize the visibility on the national and European levels...
April 5, 2017: Biopreservation and Biobanking
https://www.readbyqxmd.com/read/28369923/2016-proceedings-of-the-national-heart-lung-and-blood-institute-s-scientific-priorities-in-pediatric-transfusion-medicine
#19
Pablo Cure, Melania Bembea, Stella Chou, Allan Doctor, Anne Eder, Jeanne Hendrickson, Cassandra D Josephson, Alan E Mast, William Savage, Martha Sola-Visner, Philip Spinella, Simon Stanworth, Marie Steiner, Traci Mondoro, Shimian Zou, Catherine Levy, Myron Waclawiw, Nahed El Kassar, Simone Glynn, Naomi L C Luban
No abstract text is available yet for this article.
March 28, 2017: Transfusion
https://www.readbyqxmd.com/read/28368641/searching-for-axionlike-particles-in-flavor-changing-neutral-current-processes
#20
Eder Izaguirre, Tongyan Lin, Brian Shuve
We propose new searches for axionlike particles (ALPs) produced in flavor-changing neutral current (FCNC) processes. This proposal exploits the often-overlooked coupling of ALPs to W^{±} bosons, leading to FCNC production of ALPs even in the absence of a direct coupling to fermions. Our proposed searches for resonant ALP production in decays such as B→K^{(*)}a, a→γγ, and K→πa, a→γγ could greatly improve upon the current sensitivity to ALP couplings to standard model particles. We also determine analogous constraints and discovery prospects for invisibly decaying ALPs...
March 17, 2017: Physical Review Letters
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