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https://www.readbyqxmd.com/read/29663868/imaging-mass-spectrometry-of-endogenous-polypeptides-and-secondary-metabolites-from-galls-induced-by-root-knot-nematodes-in-tomato-roots
#1
Eder Alves Barbosa, Mauro Ferreira Bonfim Junior, Carlos Bloch, Thales Lima Rocha, Gilbert Engler, Janice de Almeida Engler
Nematodes are devastating pests that infect most cultivated plant species and cause considerable agricultural losses worldwide. The understanding of metabolic adjustments induced during plant-nematode interaction is crucial to generate resistant plants or to select more efficient molecules to fight against this pest. Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) has been used herein for in situ detection and mapping endogenous polypeptides and secondary metabolites from nematode-induced gall tissue...
April 17, 2018: Molecular Plant-microbe Interactions: MPMI
https://www.readbyqxmd.com/read/29663434/improvement-in-clinical-outcomes-of-patients-with-heart-failure-and-active-cocaine-use-after-%C3%AE-blocker-therapy
#2
Persio D Lopez, Adedoyin Akinlonu, Tuoyo O Mene-Afejuku, Carissa Dumancas, Mohammed Saeed, Eder H Cativo, Ferdinand Visco, Savi Mushiyev, Gerald Pekler
BACKGROUND: Cocaine use has a high prevalence in the United States and can be associated with significant cardiovascular disease, even in asymptomatic users. β-Adrenergic receptor hyperactivation is the underlying pathophysiologic pathway of cocaine cardiotoxicity. β-Blocker therapy is controversial in patients with active cocaine use. HYPOTHESIS: β-Blocker therapy is associated with clinical improvement in patients with heart failure despite active cocaine use...
April 17, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29661208/unmanipulated-haploidentical-in-comparison-with-matched-unrelated-donor-stem-cell-transplantation-in-patients-60-years-and-older-with-acute-myeloid-leukemia-a-comparative-study-on-behalf-of-the-alwp-of-the-ebmt
#3
Nicole Santoro, Myriam Labopin, Federica Giannotti, Gerard Ehninger, Dietger Niederwieser, Arne Brecht, Matthias Stelljes, Nicolaus Kröger, Herman Einsele, Matthias Eder, Michael Hallek, Bertram Glass, Jürgen Finke, Fabio Ciceri, Mohamad Mohty, Annalisa Ruggeri, Arnon Nagler
BACKGROUND: Acute myeloid leukemia (AML) is both more common and with more biologically aggressive phenotype in the elderly. Allogenic stem cell transplantation (allo-SCT) is the best treatment option in fit patients. Either HLA-matched unrelated donor (MUD) or haploidentical (Haplo) donor are possible alternative for patients in need. METHODS: We retrospectively compared non-T-cell-depleted Haplo (n = 250) to 10/10 MUD (n = 2589) in AML patients ≥ 60 years...
April 16, 2018: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/29656378/exopolysaccharides-from-lactobacillus-plantarum-induce-biochemical-and-physiological-alterations-in-tomato-plant-against-bacterial-spot
#4
Juliane Mendes Lemos Blainski, Argus Cesar da Rocha Neto, Eder Carlos Schimidt, José Afonso Voltolini, Márcio José Rossi, Robson Marcelo Di Piero
This study aimed to evaluate the effectiveness of exopolysaccharides (EPS) produced by Lactobacillus plantarum in controlling bacterial spot and eliciting defense mechanisms, and verify alterations in the tomato plant physiological responses. Tomato plants with five definitive leaves were sprayed with EPS, acibenzolar-S-methyl (ASM, positive control), or distilled water (negative control) and inoculated with Xanthomonas gardneri after 3 days. Local and systemic protection was evaluated 7, 15, and 21 days after inoculation...
April 14, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29648864/mechanisms-underlying-effects-of-approach-avoidance-training-on-stimulus-evaluation
#5
Pieter Van Dessel, Andreas B Eder, Sean Hughes
Over the past decade an increasing number of studies across a range of domains have shown that the repeated performance of approach and avoidance (AA) actions in response to a stimulus leads to changes in the evaluation of that stimulus. The dominant (motivational-systems) account in this area claims that these effects are caused by a rewiring of mental associations between stimulus representations and AA systems that evolved to regulate distances to positive and negative stimuli. In contrast, two recently forwarded alternative accounts postulate that AA effects are caused by inferences about the valence of actions and stimuli (inferential account) or a transfer of valenced action codes to stimulus representations (common-coding account)...
April 12, 2018: Journal of Experimental Psychology. Learning, Memory, and Cognition
https://www.readbyqxmd.com/read/29643419/author-correction-synergistic-effect-of-human-bone-morphogenic-protein-2-and-mesenchymal-stromal-cells-on-chronic-wounds-through-hypoxia-inducible-factor-1-%C3%AE-induction
#6
Sabine François, Véronique Eder, Karim Belmokhtar, Marie-Christine Machet, Luc Douay, Norbert-Claude Gorin, Marc Benderitter, Alain Chapel
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
April 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29626067/endothelial-c-type-natriuretic-peptide-acts-on-pericytes-to-regulate-microcirculatory-flow-and-blood-pressure
#7
Katarina Špiranec, Wen Chen, Franziska Werner, Viacheslav O Nikolaev, Takashi Naruke, Franziska Koch, Andrea Werner, Petra Eder-Negrin, Rodrigo Diéguez-Hurtado, Ralf H Adams, Hideo A Baba, Hannes Schmidt, Kai Schuh, Boris V Skryabin, Kiavash Movahedi, Frank Schweda, Michaela Kuhn
Background -Peripheral vascular resistance has a major impact on arterial blood pressure levels. Endothelial C-type natriuretic peptide (CNP) participates in the local regulation of vascular tone but the target cells remain controversial. The cGMP-producing guanylyl cyclase-B (GC-B) receptor for CNP is expressed in vascular smooth muscle cells (VSMC). However, whereas endothelial cell-specific CNP knockout mice are hypertensive, mice with deletion of GC-B in VSMC have unaltered blood pressure. Methods -We analyzed whether the vasodilating response to CNP changes along the vascular tree, i...
April 6, 2018: Circulation
https://www.readbyqxmd.com/read/29582424/antinociceptive-and-anti-inflammatory-effects-of-1-2-bis-4-methoxyphenylselanyl-styrene-in-mice-involvement-of-the-serotonergic-system
#8
Roberta Gonçalves Anversa, Fernanda Severo Sabedra Sousa, Paloma Taborda Birmann, David Borba Lima, Eder João Lenardão, César Augusto Bruning, Lucielli Savegnago
BACKGROUND: Pain is one of the most prevalent, costly and disabling conditions that reduces quality of life. Although there are many analgesics available, there is some concern regarding their efficacy, safety and side effects. Organic selenium compounds are attractive targets of various research groups due to their pharmacological properties. OBJECTIVES: The aim of this study was to evaluate the antinociceptive and anti-inflammatory activity of 1,2-bis-(4-methoxyphenylselanyl) styrene (BMOSE) in mice, as well as to investigate the mechanism involved in the antinociceptive effect...
March 27, 2018: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/29573849/dactylitis-a-hallmark-of-psoriatic-arthritis
#9
REVIEW
Gurjit S Kaeley, Lihi Eder, Sibel Z Aydin, Marwin Gutierrez, Catherine Bakewell
OBJECTIVE: Dactylitis-long considered a hallmark clinical feature of psoriatic arthritis (PsA)-occurs in 16-49% of patients with PsA. In this review, we discuss the pathology of dactylitis in PsA and clinical and imaging tools used to diagnose and monitor dactylitis. METHODS: PubMed literature searches were conducted using the terms psoriatic arthritis, dactylitis, pathology, imaging, ultrasound, magnetic resonance imaging, clinical, and indices. Articles were deemed relevant if they provided insight into the pathology, diagnosis, and/or monitoring of dactylitis in PsA, or if they discussed clinical or imaging indices used to assess dactylitis...
February 14, 2018: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29558031/interleukin-6-osteoprotegerin-srankl-and-bone-metabolism-in-inflammatory-bowel-diseases
#10
Iwona Krela-Kaźmierczak, Aleksandra Szymczak-Tomczak, Liliana Łykowska-Szuber, Ewa Wysocka, Michał Michalak, Kamila Stawczyk-Eder, Katarzyna Waszak, Krzysztof Linke, Piotr Eder
BACKGROUND: Cytokines are mediators of inflammatory processes in the course of inflammatory bowel disease (IBD) and participate in the bone metabolism. Interleukin 6 (IL-6) initiates osteoclastogenesis by modulating the activity of soluble receptor activator of nuclear factor kappa B ligand (sRANKL) and osteoprotegerin. OBJECTIVES: The aim of the study was to evaluate bone mineral density (BMD) by densitometry and the concentration of interleukin 6, osteoprotegerin (OPG) and sRANKL protein (sRANKL) by ELISA in patients with IBD in relation to the control group; to assess the relationship between IL-6, OPG, sRANKL and BMD; and to assess the impact of disease duration and number hospitalization on BMD...
March 20, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29549036/safety-and-immunogenicity-of-an-inactivated-vero-cell_derived-japanese-encephalitis-vaccine-ixiaro-%C3%A2-jespect-%C3%A2-in-a-pediatric-population-in-je-non-endemic-countries-an-uncontrolled-open-label-phase-3-study
#11
Tomas Jelinek, Michael A Cromer, Jakob P Cramer, Deborah J Mills, Kenneth Lessans, Anthony W Gherardin, Elizabeth D Barnett, Stefan H F Hagmann, Helena H Askling, Sigrid Kiermayr, Vera Kadlecek, Susanne Eder-Lingelbach, Christian Taucher, Katrin L Dubischar
BACKGROUND: Young travelers to South-East Asia may be at risk for Japanese encephalitis (JE). METHODS: IXIARO® (0.25 ml or 0.5 ml, depending on age) were administrated to 100 travelers aged ≥ 2 months to < 18 years. Solicited AEs were collected for 7 days after each injection, unsolicited adverse events (AEs) for a total of 7 months. JE neutralizing antibodies were assessed in 64 subjects. RESULTS: The most common solicited local AEs were redness (3/12 subjects), induration and tenderness (both 1/12) with 0...
March 13, 2018: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29545636/analytical-prediction-of-the-piezoelectric-d-33-response-of-fluoropolymer-arrays-with-tubular-air-channels
#12
Sergey Zhukov, Dagmar Eder-Goy, Sergey Fedosov, Bai-Xiang Xu, Heinz von Seggern
The present study is focused on tubular multi-channel arrays composed of commercial fluoropolymer (FEP) tubes with different wall thickness. After proper charging in a high electric field, such tubular structures exhibit a large piezoelectric [Formula: see text] coefficient significantly exceeding the values of classical polymer ferroelectrics and being even comparable to conventional lead-free piezoceramics. The quasistatic piezoelectric [Formula: see text] coefficient was theoretically derived and its upper limits were evaluated considering charging and mechanical properties of the arrays...
March 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29542924/tuning-heterocalixarenes-to-improve-their-anion-recognition-a-computational-approach
#13
Alexandre Osmar Ortolan, Ina Oestroem, Giovanni Finoto Caramori, Renato Luis Tame Parreira, Eder Henrique da Silva, F Matthias Bickelhaupt
We have explored and analysed the physical factors through which non-covalent in- teractions in anion sensing based on calixarene-type hosts can be tuned, using dispersion- corrected DFT and Kohn-Sham molecular orbital (KS-MO) theory in conjunction with a canonical energy decomposition analysis (EDA). We find that the host-guest interac- tion can be enhanced through the introduction of strongly electron-withdrawing groups at particular positions of the arene and triazine units in the host molecule as well as by coordination of a metal complex to the arene and triazine rings...
March 15, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29535001/3-4-chlorophenylselanyl-1-methyl-1h-indole-a-new-selenium-compound-elicits-an-antinociceptive-and-anti-inflammatory-effect-in-mice
#14
Paloma T Birmann, Fernanda S S Sousa, Daniela H de Oliveira, Micaela Domingues, Beatriz M Vieira, Eder J Lenardão, Lucielli Savegnago
Several pathologies, such as pain and inflammation, are modulated by different pathways, making it necessary to develop drugs capable of modulating different pathways. Based on that, we investigated the antinociceptive and anti-inflammatory effect of 3-(4-chlorophenylselanyl)-1-methyl-1H-indole (CMI), as well as the systems involved in these actions. This study evaluated the antinociceptive and anti-inflammatory effects of CMI [0.0001-10mg/kg administered intragastrically (i.g.)] in the formalin, glutamate, hot plate, ear edema induced by croton oil and paw edema induced by formalin tests...
March 10, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29534683/challenges-of-interpreting-epidemiologic-surveillance-pertussis-data-with-changing-diagnostic-and-immunization-practices-the-case-of-the-state-of-s%C3%A3-o-paulo-brazil
#15
Eder Gatti Fernandes, Ana Marli Christovam Sartori, Patrícia Coelho de Soárez, Telma Regina M P Carvalhanas, Marcela Rodrigues, Hillegonda Maria Dutilh Novaes
BACKGROUND: A significant increase in pertussis incidence occurred in Brazil, from 2011 to 2014, despite high coverage of childhood immunization with whole-cell-pertussis (wP) containing vaccines. This study presents pertussis surveillance data from São Paulo state and discusses the challenges to interpret them considering pertussis cyclic epidemic behavior, the introduction of new diagnostic techniques and new vaccination strategies, and enhanced disease awareness during epidemics. METHODS: Observational study including pertussis cases reported to the Surveillance System in São Paulo state, from January 2001 to December 2015...
March 13, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29532075/effect-of-protein-intake-on-lean-body-mass-in-functionally-limited-older-men-a-randomized-clinical-trial
#16
Shalender Bhasin, Caroline M Apovian, Thomas G Travison, Karol Pencina, Lynn L Moore, Grace Huang, Wayne W Campbell, Zhuoying Li, Andrew S Howland, Ruo Chen, Philip E Knapp, Martha R Singer, Mitali Shah, Kristina Secinaro, Richard V Eder, Kathleen Hally, Haley Schram, Richelle Bearup, Yusnie M Beleva, Ashley C McCarthy, Erin Woodbury, Jennifer McKinnon, Geeta Fleck, Thomas W Storer, Shehzad Basaria
Importance: The Institute of Medicine set the recommended dietary allowance (RDA) for protein at 0.8 g/kg/d for the entire adult population. It remains controversial whether protein intake greater than the RDA is needed to maintain protein anabolism in older adults. Objective: To investigate whether increasing protein intake to 1.3 g/kg/d in older adults with physical function limitations and usual protein intake within the RDA improves lean body mass (LBM), muscle performance, physical function, fatigue, and well-being and augments LBM response to a muscle anabolic drug...
March 12, 2018: JAMA Internal Medicine
https://www.readbyqxmd.com/read/29521598/rhinovirus-infection-induces-distinct-transcriptome-profiles-in-polarized-human-macrophages
#17
Charu Rajput, Megan P Walsh, Breanna N Eder, Ediri E Metitiri, Antonia P Popova, Marc B Hershenson
Infections with rhinovirus (RV) cause asthma exacerbations. Recent studies suggest that macrophages play a role in asthmatic airway inflammation and the innate immune response to RV infection. Macrophages exhibit discrete phenotypes based on surface markers and gene expression. We hypothesized that macrophage polarization state alters gene expression in response to RV infection. Cells were derived from human peripheral blood derived monocytes. M1 and M2 polarization was carried out using IFN-y and IL-4, respectively, and RNA was extracted for Affymetrix Human Gene ST2...
March 9, 2018: Physiological Genomics
https://www.readbyqxmd.com/read/29521343/sub-mucosal-swelling
#18
A Eder
No abstract text is available yet for this article.
March 9, 2018: British Dental Journal
https://www.readbyqxmd.com/read/29504257/correlation-of-retinal-neurodegeneration-with-measures-of-peripheral-autonomic-neuropathy-in-type-1-diabetes
#19
Berthold Pemp, Stefan Palkovits, Kinga Howorka, Jiri Pumprla, Stefan Sacu, Gerhard Garhöfer, Michaela Bayerle-Eder, Leopold Schmetterer, Ursula Schmidt-Erfurth
PURPOSE: To evaluate the relationship of neuroretinal layer thickness with sensitive measures of cardiovascular autonomic neuropathy in diabetic patients with non-proliferative diabetic retinopathy (NPDR). METHODS: Twenty-seven eyes of 27 patients with type 1 diabetes presenting with mild-to-moderate NPDR were compared to 27 healthy control (HC) eyes matched for age and gender. The total macular volume (TMV) and the volumes of individual neurosensory layers in the macula were analysed from spectral domain optical coherence tomography using automated layer segmentation...
March 5, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29495249/phytochemical-analysis-by-hplc-hresi-ms-and-anti-inflammatory-activity-of-tabernaemontana-catharinensis
#20
José Ivan Marques, Jovelina Samara Ferreira Alves, Manoela Torres-Rêgo, Allanny Alves Furtado, Emerson Michell da Silva Siqueira, Eder Galinari, Daline Fernandes de Souza Araújo, Gerlane Coelho Bernardo Guerra, Eduardo Pereira de Azevedo, Matheus de Freitas Fernandes-Pedrosa, Silvana Maria Zucolotto
Tabernaemontana catharinensis (Apocynaceae) has been popularly used by folk medicine because of its anti-inflammatory, analgesic, and antiophidic properties. This study aims to analyze the flavonoids composition of the hydroethanolic extract and of the ethyl acetate (EtOAc) and butanol (BuOH) fractions of T. catharinensis leaves, as well as to evaluate their anti-inflammatory activity using in vivo models. The phytochemical profile, determined by High-Performance Liquid Chromatography-High-Resolution Electrospray Ionization-Mass Spectrometry (HPLC-HRESI-MS), showed the presence of flavonoids mainly having an isorhamnetin nucleus...
February 24, 2018: International Journal of Molecular Sciences
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