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https://www.readbyqxmd.com/read/28204811/isopsoralen-mediated-suppression-of-bone-marrow-adiposity-and-attenuation-of-the-adipogenic-commitment-of-bone-marrow-derived-mesenchymal-stem-cells
#1
Jian Wang, Sheng-Fa Li, Ting Wang, Chun-Han Sun, Liang Wang, Min-Jun Huang, Jian Chen, Shao-Wei Zheng, Nan Wang, Ying-Jun Zhang, Tian-Yu Chen
Osteoporosis (OP) increases the risk of bone fractures and other complications, and is thus a major clinical problem. In this study, we examined the effect of isopsoralen on the differentiation of bone-derived marrow mesenchymal stem cells (BMSCs) into osteoblasts and adipocytes, as well as bone formation under osteoporotic conditions. Primary femoral BMSCs isolated from C57BL/6 mice were used to evaluate the isopsoralen-mediated regulation of the expression of alkaline phosphatase (ALP), osteocalcin (OCN) and runt-related transcription factor 2 (RUNX2) during osteogenesis 2 weeks...
February 6, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28198592/bone-marrow-derived-mesenchymal-stem-cells-derived-exosomes-promote-survival-of-retinal-ganglion-cells-through-mirna-dependent-mechanisms
#2
Ben Mead, Stanislav Tomarev
The loss of retinal ganglion cells (RGC) and their axons is one of the leading causes of blindness and includes traumatic (optic neuropathy) and degenerative (glaucoma) eye diseases. Although no clinical therapies are in use, mesenchymal stem cells (MSC) have demonstrated significant neuroprotective and axogenic effects on RGC in both of the aforementioned models. Recent evidence has shown that MSC secrete exosomes, membrane enclosed vesicles (30-100 nm) containing proteins, mRNA and miRNA which can be delivered to nearby cells...
February 15, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28198165/vascular-endothelial-growth-factor-transfected-adipose-derived-stromal-cells-enhance-bone-regeneration-and-neovascularization-from-bone-marrow-stromal-cells
#3
Mi-Lan Kang, Ji-Eun Kim, Gun-Il Im
Vascular endothelial growth factor (VEGF)-transfected adipose-derived stromal cells (ADSCs(VEGF) ) were devised to promote bone regeneration and neovascularization of bone marrow stromal cells (BMSCs). ADSCs(VEGF) were added to BMSCs and cocultured in variable proportions. ADSCs(VEGF) alone or ADSCs(VEGF) with BMSCs (BMSCs:ADSCs(VEGF) ratio of 1:0.025-0.5) induced significantly greater tube formation in human umbilical vein endothelial cells than untransfected ADSCs. The cocultures of BMSCs and ADSCs(VEGF) at ratios of 1: 0...
February 15, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28190794/a-randomized-comparative-study-on-the-efficacy-of-intracoronary-infusion-of-autologous-bone-marrow-mononuclear-cells-and-mesenchymal-stem-cells-in-patients-with-dilated-cardiomyopathy
#4
Wentao Xiao, Suping Guo, Chuanyu Gao, Guoyou Dai, Yongjv Gao, Muwei Li, Xianpei Wang, Dayi Hu
Stem cell therapy has shown therapeutic benefit in dilated cardiomyopathy (DCM), but doubt remains about the most appropriate stem cell subpopulation. The current study compared the efficacy of intracoronary administration of bone marrow mononuclear cells (BMMC) or mesenchymal stem cells (BMSC) in patients with DCM.Fifty-three patients with DCM and reduced (< 40%) left ventricular ejection fraction (LVEF), were randomized to intracoronary infusion of BMMC (BMMC group, n = 16) or BMSC (BMSC group, n = 17) or equal volume normal saline (CTRL group, n = 20)...
February 13, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28186701/bone-marrow-derived-mesenchymal-stem-cells-derived-exosomes-promote-survival-of-retinal-ganglion-cells-through-mirna-dependent-mechanisms
#5
Ben Mead, Stanislav Tomarev
The loss of retinal ganglion cells (RGC) and their axons is one of the leading causes of blindness and includes traumatic (optic neuropathy) and degenerative (glaucoma) eye diseases. Although no clinical therapies are in use, mesenchymal stem cells (MSC) have demonstrated significant neuroprotective and axogenic effects on RGC in both of the aforementioned models. Recent evidence has shown that MSC secrete exosomes, membrane enclosed vesicles (30-100 nm) containing proteins, mRNA and miRNA which can be delivered to nearby cells...
January 26, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28162996/identification-of-bone-marrow-derived-soluble-factors-regulating-human-mesenchymal-stem-cells-for-bone-regeneration
#6
Tsung-Lin Tsai, Wan-Ju Li
Maintaining properties of human bone marrow-derived mesenchymal stem cells (BMSCs) in culture for regenerative applications remains a great challenge. An emerging approach of constructing a culture environment mimicking the bone marrow niche to regulate BMSC activities has been developed. In this study, we have demonstrated a systematic approach to identify soluble factors of interest extracted from human bone marrow and used them in BMSC culture for tissue regeneration. We have found that lipocalin-2 and prolactin are key factors in bone marrow, involved in regulating BMSC activities...
February 14, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28161640/gastrodin-inhibits-osteoclastogenesis-via-down-regulating-the-nfatc1-signaling-pathway-and-stimulates-osseointegration-in-vitro
#7
Feng Zhou, Yi Shen, Bo Liu, Xia Chen, Lu Wan, Dan Peng
Bone is a rigid yet dynamic organ, and this dynamism is mediated by the delicate balance between osteoclastic bone resorption and osteoblastic bone formation. However, excessive activation of osteoclasts is responsible for many bone diseases such as osteoporosis, Paget disease, and tumor bone metastasis. Agents that could inhibit osteoclast formation or function are regarded as promising alternatives to treat osteoclast-related diseases. Recently, traditional Chinese medicine has attracted attention because of its multiple activities in bone metabolism...
February 1, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28160570/resistance-of-leukemia-cells-to-cytarabine-chemotherapy-is-mediated-by-bone-marrow-stroma-involves-cell-surface-equilibrative-nucleoside-transporter-1-removal-and-correlates-with-patient-outcome
#8
Patricia Macanas-Pirard, Richard Broekhuizen, Alfonso González, Claudia Oyanadel, Daniel Ernst, Patricia García, Viviana P Montecinos, Felipe Court, Mauricio Ocqueteau, Pablo Ramirez, Bruno Nervi
The interaction between acute myeloid leukemia cells (AML) with the bone marrow stroma cells (BMSCs) determines a protective environment that favors tumor development and resistance to conventional chemotherapy. We showed that BMSCs secrete soluble factors that protect AML cells from Ara-C induced cytotoxicity. This leukemia chemoresistance is associated with a decrease in the equilibrative nucleoside transporter (ENT1) activity by inducing removal of ENT1 from the cell surface. Reduction of cell proliferation was also observed with activation of AKT and mTOR-dependent cell survival pathways, which may also contribute to the tumor chemoprotection...
February 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28157203/hepatocyte-growth-factor-secreted-by-bone-marrow-stem-cell-reduce-er-stress-and-improves-repair-in-alveolar-epithelial-ii-cells
#9
Izabela Nita, Katrin Hostettler, Luca Tamo, Michaela Medová, Giuseppe Bombaci, Jun Zhong, Ramanjaneyulu Allam, Yitzhak Zimmer, Michael Roth, Thomas Geiser, Amiq Gazdhar
Idiopathic Pulmonary Fibrosis (IPF) is a progressive, irreversible lung disease with complex pathophysiology. Evidence of endoplasmic reticulum (ER) stress has been reported in alveolar epithelial cells (AEC) in IPF patients. Secreted mediators from bone marrow stem cells (BMSC-cm) have regenerative properties. In this study we investigate the beneficial effects of BMSC-cm on ER stress response in primary AEC and ER stressed A549 cells. We hypothesize that BMSC-cm reduces ER stress. Primary AEC isolated from IPF patients were treated with BMSC-cm...
February 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28156084/bone-marrow-derived-mesenchymal-stem-cell-loaded-fibrin-patches-act-as-a-reservoir-of-paracrine-factors-in-chronic-myocardial-infarction
#10
Eléonore Blondiaux, Laetitia Pidial, Gwennhael Autret, Gabriel Rahmi, Daniel Balvay, Etienne Audureau, Claire Wilhelm, Coralie L Guerin, Patrick Bruneval, Jean-Sébastien Silvestre, Philippe Menasché, Olivier Clément
The combination of mesenchymal stem cells and tissue-engineered fibrin patches improves the therapeutic efficacy of stem cells. In vivo cardiac magnetic resonance (4.7 Tesla) and ex vivo high-spatial resolution CMR were used to track the fate of human bone marrow-derived mesenchymal stem cell (BMSC) delivered on an epicardial scaffold and more specifically assess their potential intramyocardial migration. Fifty-seven nude rats underwent permanent coronary artery ligation. Two months later, those with a left ventricular ejection fraction ≤55% were randomly allocated to receive a patch loaded with human BMSC (BMSC-P, n = 10), a patch loaded with BMSCs labelled with iron oxide nanoparticles (BMSC*-P, n = 12), an acellular patch (A-P, n = 8) or to serve as sham-operated animals (SHAM, n = 7)...
February 3, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28135571/similarities-and-differences-between-porcine-mandibular-and-limb-bone-marrow-mesenchymal-stem-cells
#11
Brandon Lloyd, Boon Ching Tee, Colwyn Headley, Hany Emam, Susan Mallery, Zongyang Sun
OBJECTIVE: Research has shown promise of using bone marrow mesenchymal stem cells (BMSCs) for craniofacial bone regeneration; yet little is known about the differences of BMSCs from limb and craniofacial bones. This study compared pig mandibular and tibia BMSCs for their in vitro proliferation, osteogenic differentiation properties and gene expression. DESIGN: Bone marrow was aspirated from the tibia and mandible of 3-4 month-old pigs (n=4), followed by BMSC isolation, culture-expansion and characterization by flow cytometry...
January 20, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28131959/yap-mediated-mechanotransduction-regulates-osteogenic-and-adipogenic-differentiation-of-bmscs-on-hierarchical-structure
#12
Houhua Pan, Youtao Xie, Zequan Zhang, Kai Li, Dandan Hu, Xuebin Zheng, Qiming Fan, Tingting Tang
Hierarchical structure mimicking the natural bone microenvironment has been considered as a promising platform to regulate cell functions. We have previously fabricated hierarchical macropore/nanowire structure and evidence has shown that it can better manipulate the cytoskeleton status and osteogenic performance of osteoblasts. However, how cues of hierarchical structure are translated and ultimately linked to BMSC lineage commitment have still remained elusive, which hinders the accurate knowledge and further development of the hierarchical structure...
January 23, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28125630/fluoride-regulate-osteoblastic-transforming-growth-factor-%C3%AE-1-signaling-by-mediating-recycling-of-the-type-i-receptor-alk5
#13
Chen Yang, Yan Wang, Hui Xu
This study aimed to preliminary investigate the role of activin receptor-like kinase (ALK) 5 as one of TGF-βR1 subtypes in bone turnover and osteoblastic differentiation induced by fluoride. We analyzed bone mineral density and the expression of genes related with transforming growth factor-β1(TGF-β1) signaling and bone turnover in rats treated by different concentrations of fluoride with or without SB431542 in vivo. Moreover, MTT assay, alkaline phosphatase staining, RT-PCR, immunocytochemical analysis and western blot analysis were used to detect the influence on bone marrow stem cells (BMSC) after stimulating by varying concentration of fluoride with or without SB431542 in vitro...
2017: PloS One
https://www.readbyqxmd.com/read/28124102/in-vitro-chondrogenic-potential-of-synovial-stem-cells-and-chondrocytes-allocated-for-autologous-chondrocyte-implantation-a-comparison-synovial-stem-cells-as-an-alternative-cell-source-for-autologous-chondrocyte-implantation
#14
Eva Johanna Kubosch, Emanuel Heidt, Philipp Niemeyer, Anke Bernstein, Norbert P Südkamp, Hagen Schmal
PURPOSE: The use of passaged chondrocytes is the current standard for autologous chondrocyte implantation (ACI). De-differentiation due to amplification and donor site morbidity are known drawbacks highlighting the need for alternative cell sources. METHODS: Via clinically validated flow cytometry analysis, we compared the expression of human stem cell and cartilage markers (collagen type 2 (Col2), aggrecan (ACAN), CD44) of chondrocytes (CHDR), passaged chondrocytes for ACI (CellGenix™), bone marrow derived mesenchymal stem cells (BMSC), and synovial derived stem cells (SDSC)...
January 25, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28123635/bmsc-paracrine-activity-attenuates-interleukin-1%C3%AE-induced-inflammation-and-apoptosis-in-rat-af-cells-via-inhibiting-relative-nf-%C3%AE%C2%BAb-signaling-and-the-mitochondrial-pathway
#15
Jinquan Hu, Qiang Yan, Changgui Shi, Ye Tian, Peng Cao, Wen Yuan
We previously showed that bone mesenchymal stem cells (BMSCs) inhibit interleukin-1 beta (IL-1β) induced degenerative effects in NP cells by their paracrine activity, but the anti-inflammatory and anti-apoptotic effect of BMSC paracrine activity and the relative signaling pathway were not further investigated in annulus fibrosus (AF) cells. In this study, AF cells were exposed to IL-1β, which was applied to mimic intervertebral disc degeneration (IDD) in vitro. Indirect co-culture with BMSCs in a transwell co-culture system reduced the activity of nuclear factor-κB-p65 (NF-κB-p65) through the restoration of its inhibitor IκBa...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28121340/research-on-the-effect-and-mechanism-of-the-cxcr-4-overexpressing-bmscs-combined-with-sdf-1%C3%AE-for-the-cure-of-acute-sci-in-rats
#16
B-W Sun, H-M Shen, B-C Liu, H-L Fang
OBJECTIVE: To evaluate the effect and mechanism of bone marrow stem cells (BMSCs) modified with CXCR-4 gene combined with stromal derived factor-1α (SDF-1α) in the treatment of acute spinal cord injury (SCI) in rats. MATERIALS AND METHODS: CXCR-4 gene was transfected by a virus. Spinal cord injury rats were randomly divided into four groups: control group, SDF-1α group, CXCR-4/BMSC group and combined group. The motor function was evaluated with Blood Brain Barrier (BBB) score and the RNA expression of CXCR-4 were measured by PCR...
January 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28120372/graphene-oxide-nanolayers-as-nanoparticle-anchors-on-biomaterial-surfaces-with-nanostructures-and-charge-balance-for-bone-regeneration
#17
Chaoming Xie, Honglong Sun, Kefeng Wang, Wei Zheng, Xiong Lu, Fuzeng Ren
Graphene oxide (GO) is a carbon-based nanomaterial with high surface area and abundant functional groups, providing various sites for binding and immobilization of growth factor vehicles. This study used GO nanolayer as an anchor for the immobilization of bone morphogenetic protein-2 (BMP-2)-encapsulated bovine serum albumin nanoparticles (NPs) on the hydroxyapatite (HA) and tricalcium phosphate (TCP) scaffolds by electrostatic interaction between the positive charges of the NPs and negative charges of GO. GO nanolayers prevented the rapid degradation of TCP scaffolds...
January 25, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28116858/a-copolymer-scaffold-functionalized-with-nanodiamond-particles-enhances-osteogenic-metabolic-activity-and-bone-regeneration
#18
Mohammed A Yassin, Kamal Mustafa, Zhe Xing, Yang Sun, Kristine Eldevik Fasmer, Thilo Waag, Anke Krueger, Doris Steinmüller-Nethl, Anna Finne-Wistrand, Knut N Leknes
Functionalizing polymer scaffolds with nanodiamond particles (nDPs) has pronounced effect on the surface properties, such as improved wettability, an increased active area and binding sites for cellular attachment and adhesion, and increased ability to immobilize biomolecules by physical adsorption. This study aims to evaluate the effect of poly(l-lactide-co-ε-caprolactone) (poly(LLA-co-CL)) scaffolds, functionalized with nDPs, on bone regeneration in a rat calvarial critical size defect. Poly(LLA-co-CL) scaffolds functionalized with nDPs are also compared with pristine scaffolds with reference to albumin adsorption and seeding efficiency of bone marrow stromal cells (BMSCs)...
January 24, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/28115014/effect-of-mesenchymal-stem-cells-on-small-intestinal-injury-in-a-rat-model-of-acute-necrotizing-pancreatitis
#19
Fengchun Lu, Feng Wang, Zhiyao Chen, Heguang Huang
BACKGROUND: Acute necrotizing pancreatitis (ANP) is often complicated by multiple organ failure. The small intestine is frequently damaged during ANP. Capillary leakage in multiple organs during ANP is one of the most important causes of multiple organ dysfunction. Damage to the capillary endothelial barrier and impaired water transportation could lead to capillary leakage in ANP. METHODS: Sprague-Dawley (SD) rats were randomized into a control group, the ANP group, the culture media-treated group, or the bone marrow-derived mesenchymal stem cell (BMSC)-treated group (30 rats in each group)...
January 23, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28109140/-transplantation-of-bone-marrow-mesenchymal-stem-cell-improves-antioxidant-capacity-and-immune-activity-of-aging-model-rats
#20
Zhihong Wang, Yun Lin, Weimin Chen, Jin Shang, Tiannan Wei
Objective To investigate the impact of bone marrow mesenchymal stem cell (BMSC) transplantation on the antioxidant capacity and immune activity of aging rats induced by D-galactose. Methods Ten healthy male SD rats served as a control group (aged 2 months). To establish aging models, healthy SD rats were daily injected subcutaneously with D-galactose (400 mg/kg). Then the aging model rats were randomized into aging model group and BMSC group (ten rats in each group). The BMSC group was injected with 3×10(6) BMSCs via tail vein...
February 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
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