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https://www.readbyqxmd.com/read/26897490/is-there-a-benefit-for-liposomal-bupivacaine-compared-to-a-traditional-periarticular-injection-in-total-knee-arthroplasty-patients-with-a-history-of-chronic-opioid-use
#1
Ran Schwarzkopf, Michael Drexler, Michael W Ma, Vanessa M Schultz, Khanhvan T Le, Tal Frenkel Rutenberg, Joseph B Rinehart
BACKGROUND: Postoperative pain after total knee arthroplasty (TKA) poses a major challenge. It delays mobilization, increases opioid consumption and side effects, and lengthens hospitalization. This challenge multiplies when treating an opioid-dependent population. We examined whether a novel suspended release local anesthetic, liposomal bupivacaine (LB) would improve pain control and decrease opioid consumption after TKA compared to a standard periarticular injection in opioid-dependent patients...
August 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/12136845/cavernous-and-systemic-plasma-levels-of-norepinephrine-and-epinepherine-during-different-penile-conditions-in-healthy-men-and-patients-with-erectile-dysfunction
#2
https://www.readbyqxmd.com/read/10608045/effects-of-recombinant-human-megakaryocyte-growth-and-development-factor-rhumgdf-on-platelet-production-platelet-aggregation-and-thrombosis
#3
Lott, Nelson, Toombs
Recombinant human megakaryocyte growth and development factor (rHuMGDF) is a c-mpl ligand that promotes the differentiation of CD34+ precursor cells into megakaryocyte, and then platelets. In experimental animals, injection of this and other c-mpl ligands leads to profound increases in the circulating platelet count in a matter of days. However, c-mpl ligands have also been shown to sensitize platelets to aggregating agents in vitro, raising the possibility that c-mpI ligands may have prothrombotic effects in vivo...
1998: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/9338913/unexplained-neurologic-deficit-after-uneventful-combined-spinal-and-epidural-anesthesia-for-cesarean-delivery
#4
M J Paech
BACKGROUND AND OBJECTIVES: Neurologic deficits after spinal and epidural anesthesia are uncommon and have a variety of pathophysiologic mechanisms. Local anesthetic neurotoxicity may occur, although subarachnoid bupivacaine has an unblemished clinical record. METHODS: A healthy parturient underwent uneventful combined spinal and epidural anesthesia for elective cesarean delivery. Intraspinal drugs administered included hyperbaric bupivacaine 0.5% and fentanyl (subarachnoid) and 2% lidocaine with epinepherine 1:200,000 and meperidine (epidural)...
September 1997: Regional Anesthesia
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