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https://www.readbyqxmd.com/read/28571540/caffeic-acid-in-dermatological-formulations-in-vitro-release-profile-and-skin-absorption
#1
Caroline Magnani Spagnol, Leonardo Delello Di Filippo, Vera Lucia Borges Isaac, Marcos Antonio Corrêa, Hérida Regina Nunes Salgado
Caffeic acid (CA) is a cinnamic acid derivative, found in many vegetable products, with powerful antioxidant activity, the ability to increase collagen production and capacity to prevent premature aging of the skin. The classic emulsions of CA are widely used by the consumer to provide a pleasant, refreshing sensorial experience; however, preparations developed in the form of dry film are presented as a technological alternative due to its facile and safe transportation. The aim of this study was to evaluate the release, permeation, and retention of CA in a film and emulsion through in vitro experiments...
June 1, 2017: Combinatorial Chemistry & High Throughput Screening
https://www.readbyqxmd.com/read/28287269/a-critical-review-of-analytical-methods-for-quantification-of-cefotaxime
#2
Lívia Paganini Consortti, Hérida Regina Nunes Salgado
Bacterial resistance to antibiotics is a growing phenomenon in the world. Considering the relevance of antimicrobials for population and the reduction in the registration of new antimicrobials by regulatory, proper quality control is required in order to minimize the spread of bacterial resistance and ensure the effectiveness of a treatment, as well as safety for the patient. Among the antimicrobials is cefotaxime, a drug belonging to third-generation cephalosporins, which is highly active against Gram-negative bactéria and is used to treat central nervous system infections such as meningitis and septicemia...
July 4, 2017: Critical Reviews in Analytical Chemistry
https://www.readbyqxmd.com/read/28206879/development-and-validation-of-a-green-analytical-method-for-the-determination-of-norfloxacin-in-raw-material-by-ftir-spectrophotometry
#3
Jéssica Sayuri Hisano Natori, Eliane Gandolpho Tótoli, Hérida Regina Nunes Salgado
Norfloxacin is a broad-spectrum antimicrobial agent, widely used in humans and animals for the treatment of urinary tract infections. It is a second-generation fluoroquinolone. Several analytical methods to analyze norfloxacin have been described in the literature. However, most of them are complex and require the use of large amounts of organic solvents. This paper describes the development and validation of a green analytical method for the determination of norfloxacin in raw material by FTIR spectrophotometry...
November 1, 2016: Journal of AOAC International
https://www.readbyqxmd.com/read/28080136/isoniazid-a-review-of-characteristics-properties-and-analytical-methods
#4
Guilherme Felipe Dos Santos Fernandes, Hérida Regina Nunes Salgado, Jean Leandro Dos Santos
Isoniazid is a synthetic antimicrobial and one of the most important first-line drugs used in the treatment of tuberculosis. Since it was introduced in the therapy in 1952, the drug remains at the front line of the antituberculosis treatment mainly due to its potency and high selectivity against Mycobacterium tuberculosis. Pharmaceutical analysis and therapeutic drug monitoring of isoniazid in both, pharmaceuticals and biological samples, plays an important role to comprehend aspects regarding to bioavailability, bioequivalence and therapeutic monitoring during patients following-up...
January 12, 2017: Critical Reviews in Analytical Chemistry
https://www.readbyqxmd.com/read/28080135/characteristics-properties-and-analytical-methods-of-amoxicillin-a-review-with-green-approach
#5
REVIEW
Bianca Aparecida de Marco, Jéssica Sayuri Hisano Natori, Stefany Fanelli, Eliane Gandolpho Tótoli, Hérida Regina Nunes Salgado
Bacterial infections are the second leading cause of global mortality. Considering this fact, it is extremely important studying the antimicrobial agents. Amoxicillin is an antimicrobial agent that belongs to the class of penicillins; it has bactericidal activity and is widely used in the Brazilian health system. In literature, some analytical methods are found for the identification and quantification of this penicillin, which are essential for its quality control, which ensures maintaining the product characteristics, therapeutic efficacy and patient's safety...
May 4, 2017: Critical Reviews in Analytical Chemistry
https://www.readbyqxmd.com/read/27992028/measurement-of-the-area-of-venous-ulcers-using-two-software-programs
#6
Thaís Dresch Eberhardt, Suzinara Beatriz Soares de Lima, Luis Felipe Dias Lopes, Eline de Lima Borges, Teresinha Heck Weiller, Graziele Gorete Portella da Fonseca
Objective: to compare the measurement area of venous ulcers using AutoCAD(r) and Image Tool software. Method: this was an assessment of reproducibility tests conducted in a angiology clinic of a university hospital. Data were collected from 21 patients with venous ulcers, in the period from March to July of 2015, using a collection form and photograph of wounds. Five nurses (evaluators) of the hospital skin wound study group participated. The wounds were measured using both software programs...
December 19, 2016: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/27737379/factors-associated-with-the-healing-of-complex-surgical-wounds-in-the-breast-and-abdomen-retrospective-cohort-study
#7
Eline Lima Borges, José Ferreira Pires, Mery Natali Silva Abreu, Vera Lúcia de Araújo Lima, Patrícia Aparecida Barbosa Silva, Sônia Maria Soares
Objective: to estimate the healing rate of complex surgical wounds and its associated factors. Method: retrospective cohort study from 2003 to 2014 with 160 outpatients of a Brazilian university hospital. Data were obtained through consultation of the medical records. Survival function was estimated using the Kaplan-Meier method and Cox regression model to estimate the likelihood of the occurrence of healing. Results: the complex surgical wound healing rate was 67...
October 10, 2016: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/27650368/a-critical-review-of-properties-and-analytical-methods-for-the-determination-of-oxytetracyline-in-biological-and-pharmaceutical-matrices
#8
REVIEW
Rúbia Adrieli Sversut, Adriane Andrade da Silva, Teófilo Fernando Mazon Cardoso, Nájla Mohamad Kassab, Marcos Serrou do Amaral, Hérida Regina Nunes Salgado
Antibiotics have an unquestionable importance in the treatment of many infections. Oxytetracycline is an antibiotic belonging to the class of tetracyclines, available for use in human and veterinary medicine. Development of analytical methods that prove the quality and efficacy of these drugs is fundamentally important to the pharmaceutical industry. In this context, the research presents an overview of the analytical profile of oxytetracycline, describing its chemical and pharmacological properties, and analytical methods for quantification of this drug in biological samples and pharmaceutical products...
March 4, 2017: Critical Reviews in Analytical Chemistry
https://www.readbyqxmd.com/read/27591671/rp-hplc%C3%A3-hilic-chromatography-for-quantifying-ertapenem-sodium-with-a-look-at-green-chemistry
#9
Tahisa M Pedroso, Ana C D Medeiros, Herida R N Salgado
Ertapenem sodium is a polar and ionizable compound; therefore, it has little retention on traditional C18 columns in reverse-phase high-performance liquid chromatography, even using a highly-aqueous mobile phase that can result in dewetting in the stationary phase. Thus, the most coherent process for ERTM is to develop a method for Hydrophilic Interaction Chromatography. However, for the traditional methods in HILIC, the use of a highly organic mobile phase is necessary; usually an amount exceeding 80% acetonitrile is necessary...
November 1, 2016: Talanta
https://www.readbyqxmd.com/read/27500358/loaded-ce-ag-organic-inorganic-hybrids-and-their-antibacterial-activity
#10
Laurianne Truffault, Danilo Fernando Rodrigues, Hérida Regida Nunes Salgado, Celso Valentim Santilli, Sandra Helena Pulcinelli
There are requirements for surfaces with antibacterial properties in various technological fields. U-PEO hybrids with antibacterial properties were synthesized by the sol-gel process, incorporating combinations of cerium and silver salts at different silver molar fractions (0, 0.02, 0.05, 0.10, and 1) relative to the total amount of doped cations. The loaded hybrids were characterized by TGA, XRD, and Raman spectroscopy. Release tests were performed using UV-vis spectroscopy, and the antibacterial properties of the hybrids were studied in agar tests and turbidimetry assays...
November 1, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27494757/characteristics-properties-and-analytical-methods-of-cefadroxil-a-review
#11
REVIEW
Bianca Aparecida de Marco, Hérida Regina Nunes Salgado
Infections are the second leading cause of mortality worldwide and there are many reasons justifying the need for further studies of antimicrobial agents. Cefadroxil is a drug that has bactericidal activity and broad spectrum of action. Quantitative analyzes about cefadroxil are essential for the understanding of bioavailability, bioequivalence, and therapeutic control, which will ensure the product's characteristics and patients' safety. Thus, this study highlights a brief literature review about the drug and the existing methods developed for the determination of cefadroxil found in official and scientific papers...
March 4, 2017: Critical Reviews in Analytical Chemistry
https://www.readbyqxmd.com/read/27484158/cost-effectiveness-of-a-herpes-zoster-vaccination-program-among-the-french-elderly-people
#12
Emmanuel Belchior, Daniel Lévy-Bruhl, Yann Le Strat, Magid Herida
A vaccine against herpes zoster (HZ) and its complications has already proven safe and effective against infection and pain and against the related deterioration of quality of life in the elderly. In order to inform the vaccination decision-making process regarding inclusion of this vaccine in the French immunization schedule, we assessed the cost-effectiveness of several vaccination scenarios, compared to no vaccination. We chose to use a previously published Markov model. Starting vaccination in elderly individuals aged 65, 70 and 75 y old appears more cost-effective than vaccination for those aged 60 y old, with a cost-effectiveness ratio between 30,000 and 35,000 euros per quality-adjusted-life year (QALY) gained for the first 3 age groups versus 54,500 €; for the latter group...
September 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27475029/-differentiation-between-moisture-lesions-and-pressure-ulcers-using-photographs-in-a-critical-area
#13
Josefa Valls-Matarín, Mercedes Del Cotillo-Fuente, María Pujol-Vila, Rosa Ribal-Prior, Inmaculada Sandalinas-Mulero
OBJECTIVES: To identify difficulties for nurses in differentiating between moisture lesions and pressure ulcers, proper classification of pressure ulcers to assess the adequate classification of the Grupo Nacional para el Estudio y Asesoramiento de Úlceras por Presión y Heridas Crónicas (GNEAUPP) and the degree of agreement in the correct assessment by type and category of injury. METHOD: Cross-sectional study in a critical area during 2014. All nurses who agreed to participate were included...
September 2016: Enfermería Clínica
https://www.readbyqxmd.com/read/27455934/characterization-of-polymorphic-forms-of-rifaximin
#14
Ana Carolina Kogawa, Selma Gutierrez Antonio, Hérida Regina Nunes Salgado
Rifaximin is a gut-selective oral antimicrobial that has no systemic adverse effects compared with placebo. It is used for the treatment of hepatic encephalopathy, traveler's diarrhea, irritable bowel syndrome, Clostridium difficile infection, ulcerative colitis, and acute diarrhea. The crystalline form present in rifaximin, α, has minimal systemic absorption compared to the amorphous form. The objective of this study was to obtain polymorphic forms of rifaximin using recrystallization processes. The forms were characterized and studied by thermal analysis, X-ray powder diffraction, scanning electron microscopy, and solubility testing...
July 2016: Journal of AOAC International
https://www.readbyqxmd.com/read/27429835/quantification-of-rifaximin-in-tablets-by-spectrophotometric-method-ecofriendly-in-ultraviolet-region
#15
Ana Carolina Kogawa, Hérida Regina Nunes Salgado
Rifaximin is an oral nonabsorbable antibiotic that acts locally in the gastrointestinal tract with minimal systemic adverse effects. It does not have spectrophotometric method ecofriendly in the ultraviolet region described in official compendiums and literature. The analytical techniques for determination of rifaximin reported in the literature require large amount of time to release results and are significantly onerous. Furthermore, they use toxic reagents both for the operator and environment and, therefore, cannot be considered environmentally friendly analytical techniques...
2016: Scientifica
https://www.readbyqxmd.com/read/27130089/rapid-turbidimetric-assay-for-quantification-of-fusidic-acid-in-a-dermatological-cream
#16
Mariane Machado Curbete, Hérida Regina Nunes Salgado
Fusidic acid is an antibiotic steroid widely used for the treatment of serious infections caused by methicillin-resistant Staphylococcus aureus (MRSA) strains. Microbiological methods are indispensable to determine the mean percentage of antimicrobial in medicaments during manufacturing and quality control processes. The aim of this study was to develop and validate a microbiological method for the quantification of fusidic acid in dermatological cream by turbidimetry, using Staphylococcus epidermidis (ATCC 12228) and casoy broth as the culture medium...
June 1, 2016: Talanta
https://www.readbyqxmd.com/read/26857445/a-critical-review-of-analytical-methods-for-determination-of-ertapenem-sodium
#17
Tahisa Marcela Pedroso, Hérida Regina Nunes Salgado
Antimicrobials have unquestionable importance in the control of many diseases; however the constant concern with evolution of resistant microorganisms is increasing. Ertapenem sodium is a β-lactam antibiotic of the carbapenem class that has a broader activity spectrum than most other β-lactam antimicrobials and is more resistant to the enzyme β-lactamase, which is the main mechanism of resistance of many bacteria. The progress of microbial resistance to existing antibiotics is alarming. Thus we need to preserve antimicrobials that still have activity against these pathogens...
2016: Critical Reviews in Analytical Chemistry
https://www.readbyqxmd.com/read/26850905/economic-evaluations-of-public-health-surveillance-systems-a-systematic-review
#18
Magid Herida, Benoit Dervaux, Jean-Claude Desenclos
No abstract text is available yet for this article.
August 2016: European Journal of Public Health
https://www.readbyqxmd.com/read/26697011/editorial-the-role-of-aire-micrornas-and-cell-cell-interactions-on-thymic-architecture-and-induction-of-tolerance
#19
Geraldo Aleixo Passos, Daniella Arêas Mendes-da-Cruz, Ernna Hérida Oliveira
No abstract text is available yet for this article.
2015: Frontiers in Immunology
https://www.readbyqxmd.com/read/26534554/evaluaci%C3%A3-n-econ%C3%A3-mica-del-uso-de-la-gasa-sint%C3%A3-tica-frente-a-la-gasa-de-algod%C3%A3-n-de-pieza-%C3%A3-nica-en-el-manejo-de-heridas-en-colombia
#20
M Romero, R Marrugo
No abstract text is available yet for this article.
November 2015: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
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