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https://www.readbyqxmd.com/read/28540509/short-term-supplementation-of-isocaloric-meals-with-l-tryptophan-affects-pig-growth
#1
H N Liu, C-A A Hu, M M Bai, Gang Liu, M C B Tossou, K Xu, F N Li, P Liao, X F Kong, X Wu, Y L Yin
L-Tryptophan (Trp) and some of its metabolites regulate the circadian rhythm in mammals. We aimed to investigate the effects of short-term supplementation of Trp in isocaloric meals on growth performance using the parameters of multiple blood biomarkers and free amino acids in growing pigs. A total of 32 Landrace × Yorkshire barrows with a mean body weight of 8.64 (±1.13) kg were randomly assigned to four groups and then fed with various concentrations of Trp diets daily. Our results showed that sequential supplementation of different concentrations of Trp in isocaloric meals decreased the feed:gain (F:G) ratio (P = 0...
May 24, 2017: Amino Acids
https://www.readbyqxmd.com/read/28500983/night-sleep-influences-white-matter-microstructure-in-bipolar-depression
#2
Francesco Benedetti, Elisa M T Melloni, Sara Dallaspezia, Irene Bollettini, Clara Locatelli, Sara Poletti, Cristina Colombo
BACKGROUND: Alteration of circadian rhythms and sleep disruption are prominent trait-like features of bipolar disorder (BD). Diffusion tensor imaging (DTI) measures suggest a widespread alteration of white matter (WM) microstructure in patients with BD. Sleep promotes myelination and oligodendrocyte precursor cells proliferation. We hypothesized a possible association between DTI measures of WM microstructure and sleep quantity measures in BD. METHODS: We studied 69 inpatients affected by a depressive episode in course of type I BD...
May 8, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28497301/various-regulatory-modes-for-circadian-rhythmicity-and-sexual-dimorphism-in-the-non-neuronal-cardiac-cholinergic-system
#3
Shino Oikawa, Yuko Kai, Asuka Mano, Hisayuki Ohata, Takahiro Nemoto, Yoshihiko Kakinuma
Cardiomyocytes possess a non-neuronal cardiac cholinergic system (NNCCS) regulated by a positive feedback system; however, its other regulatory mechanisms remain to be elucidated, which include the epigenetic control or regulation by the female sex steroid, estrogen. Here, the NNCCS was shown to possess a circadian rhythm; its activity was upregulated in the light-off phase via histone acetyltransferase (HAT) activity and downregulated in the light-on phase. Disrupting the circadian rhythm altered the physiological choline acetyltransferase (ChAT) expression pattern...
May 11, 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/28450580/longitude-position-in-a-timezone-and-cancer-risk-in-the-united-states
#4
Fangyi Gu, Shangda Xu, Susan S Devesa, Fanni Zhang, Elizabeth B Klerman, Barry I Graubard, Neil E Caporaso
BACKGROUND: Circadian disruption is a probable human carcinogen. From the eastern to western border of a timezone, social time is equal whereas solar time is progressively delayed, producing increased discrepancies between individuals' social and biological circadian time. Accordingly, western timezone residents experience greater circadian disruption and may be at an increased risk of cancer. METHODS: We examine associations between the position in a timezone (PTZ) and age-standardized county-level incidence rates for total cancers combined and 23 specific cancers by gender using the data of the Surveillance, Epidemiology, and End Results Program (2000-2012), including four million cancer diagnoses in white residents of 607 counties in 11 US states...
April 27, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28447065/circadian-clocks-diets-and-aging
#5
REVIEW
Amol Chaudhari, Richa Gupta, Kuldeep Makwana, Roman Kondratov
Diets and feeding regimens affect many physiological systems in the organism and may contribute to the development or prevention of various pathologies including cardiovascular diseases or metabolic syndromes. Some of the dietary paradigms, such as calorie restriction, have many well-documented positive metabolic effects as well as the potential to extend longevity in different organisms. Recently, the circadian clocks were put forward as integral components of the calorie restriction mechanisms. The circadian clocks generate the circadian rhythms in behavior, physiology, and metabolism; circadian disruption is associated with reduced fitness and decreased longevity...
March 31, 2017: Nutrition and Healthy Aging
https://www.readbyqxmd.com/read/28373722/simulated-microgravity-triggers-epithelial-mesenchymal-transition-in-human-keratinocytes
#6
Danilo Ranieri, Sara Proietti, Simona Dinicola, Maria Grazia Masiello, Benedetta Rosato, Giulia Ricci, Alessandra Cucina, Angela Catizone, Mariano Bizzarri, Maria Rosaria Torrisi
The microgravitational environment is known to affect the cellular behaviour inducing modulation of gene expression and enzymatic activities, epigenetic modifications and alterations of the structural organization. Simulated microgravity, obtained in the laboratory setting through the use of a Random Positioning Machine (RPM), represents a well recognized and useful tool for the experimental studies of the cellular adaptations and molecular changes in response to weightlessness. Short exposure of cultured human keratinocytes to the RPM microgravity influences the cellular circadian clock oscillation...
April 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28358954/modulation-of-circadian-rhythms-affects-corneal-epithelium-renewal-and-repair-in-mice
#7
Yunxia Xue, Peng Liu, Hanqing Wang, Chengju Xiao, Cuipei Lin, Jun Liu, Dong Dong, Ting Fu, Yabing Yang, Zhaorui Wang, Hongwei Pan, Jiansu Chen, Yangqiu Li, Dongqing Cai, Zhijie Li
Purpose: In mammalian corneal epithelium, mitosis shows a distinct circadian pattern. However, how this circadian pattern is maintained, and how it or its disruption influence renewal and regeneration remain unclear. Methods: C57BL/6 mice were maintained under 12-hour light/12-hour dark (LD), 12-hour light/12-hour light (LL), 12-hour dark/12-hour dark (DD), or reversed LD (DL, 12-hour dark/12-hour light; jet-lag defined as a shift of 12 hours) conditions. Mitotic cells in corneal epithelium were enumerated and analyzed via immunofluorescence at different zeitgeber times (ZTs)...
March 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28324596/blood-pressure-and-metabolic-changes-after-3-month-cpap-therapy-in-a-very-elderly-obese-with-severe-obstructive-sleep-apnea-a-case-report-and-review-of-the-literature
#8
Francesco Spannella, Federico Giulietti, Chiara Di Pentima, Francesca Elena Lombardi, Elisabetta Borioni, Riccardo Sarzani
Age is one of the main risk factor for the presence of obstructive sleep apnea (OSA). This syndrome is associated with hypertension, cardiovascular disease, cognitive impairment and metabolic abnormalities, such as type 2 diabetes. Continuous positive airway pressure (CPAP) represents the gold standard therapy, but its benefit is still to be determined in very elderly. We report the blood pressure and metabolic changes in a very elderly obese with severe OSA after 3-month CPAP therapy. We have evaluated a very elderly obese male affected by severe symptomatic OSA, poor controlled nocturnal hypertension and insulin resistance...
March 21, 2017: High Blood Pressure & Cardiovascular Prevention: the Official Journal of the Italian Society of Hypertension
https://www.readbyqxmd.com/read/28322269/a-ras-gtpase-associated-protein-is-involved-in-the-phototropic-and-circadian-photobiology-responses-in-fungi
#9
Silvia Polaino, José M Villalobos-Escobedo, Viplendra P S Shakya, Alejandro Miralles-Durán, Suman Chaudhary, Catalina Sanz, Mahdi Shahriari, Eva M Luque, Arturo P Eslava, Luis M Corrochano, Alfredo Herrera-Estrella, Alexander Idnurm
Light is an environmental signal perceived by most eukaryotic organisms and that can have major impacts on their growth and development. The MadC protein in the fungus Phycomyces blakesleeanus (Mucoromycotina) has been postulated to form part of the photosensory input for phototropism of the fruiting body sporangiophores, but the madC gene has remained unidentified since the 1960s when madC mutants were first isolated. In this study the madC gene was identified by positional cloning. All madC mutant strains contain loss-of-function point mutations within a gene predicted to encode a GTPase activating protein (GAP) for Ras...
March 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28262759/role-of-a-circadian-relevant-gene-nr1d1-in-brain-development-possible-involvement-in-the-pathophysiology-of-autism-spectrum-disorders
#10
Masahide Goto, Makoto Mizuno, Ayumi Matsumoto, Zhiliang Yang, Eriko F Jimbo, Hidenori Tabata, Takanori Yamagata, Koh-Ichi Nagata
In our previous study, we screened autism spectrum disorder (ASD) patients with and without sleep disorders for mutations in the coding regions of circadian-relevant genes, and detected mutations in several clock genes including NR1D1. Here, we further screened ASD patients for NR1D1 mutations and identified three novel mutations including a de novo heterozygous one c.1499 G > A (p.R500H). We then analyzed the role of Nr1d1 in the development of the cerebral cortex in mice. Acute knockdown of mouse Nr1d1 with in utero electroporation caused abnormal positioning of cortical neurons during corticogenesis...
March 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28228130/transcriptome-of-the-floral-transition-in-rosa-chinensis-old-blush
#11
Xuelian Guo, Chao Yu, Le Luo, Huihua Wan, Ni Zhen, Tingliang Xu, Jiongrui Tan, Huitang Pan, Qixiang Zhang
BACKGROUND: The floral transition plays a vital role in the life of ornamental plants. Despite progress in model plants, the molecular mechanisms of flowering regulation remain unknown in perennial plants. Rosa chinensis 'Old Blush' is a unique plant that can flower continuously year-round. In this study, gene expression profiles associated with the flowering transition were comprehensively analyzed during floral transition in the rose. RESULTS: According to the transcriptomic profiles, 85,663 unigenes and 1,637 differentially expressed genes (DEGs) were identified, among which 32 unigenes were involved in the circadian clock, sugar metabolism, hormone, and autonomous pathways...
February 23, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28154744/environmental-factors-influencing-biological-rhythms-in-newborns-from-neonatal-intensive-care-units-to-home
#12
Clarissa Bueno, Luiz Menna-Barreto
Photic and non-photic environmental factors are suggested to modulate the development of circadian rhythms in infants. Our aim is to evaluate the development of biological rhythms (circadian or ultradian) in newborns in transition from Neonatal Intensive Care Units (NICU) to home and along the first 6 months of life, to identify masking and entraining environment factors along development. Ten newborns were evaluated in their last week inside the NICU and in the first week after being delivered home; 6 babies were also followed until 6 months of corrected age...
October 2016: Sleep Science
https://www.readbyqxmd.com/read/28060525/diurnal-rhythms-in-psychological-reward-functioning-in-healthy-young-men-wanting-liking-and-learning
#13
Jamie E M Byrne, Greg Murray
A range of evidence suggests that human reward functioning is partly driven by the endogenous circadian system, generating 24-hour rhythms in behavioural measures of reward activation. Reward functioning is multifaceted but literature to date is largely limited to measures of self-reported positive mood states. The aim of this study was to advance the field by testing for hypothesised diurnal variation in previously unexplored components of psychological reward: 'wanting', liking, and learning using subjective and behavioural measures...
2017: Chronobiology International
https://www.readbyqxmd.com/read/28055262/cross-cultural-validity-of-morningness-eveningness-stability-scale-improved-messi-in-iran-spain-and-germany
#14
Arash Rahafar, Christoph Randler, Juan F Díaz-Morales, Ali Kasaeian, Zeinab Heidari
Morningness-Eveningness Stability Scale improved (MESSi) is a newly constructed measure to assess circadian types and amplitude. In this study, we applied this measure to participants from three different countries: Germany, Spain and Iran. Confirmatory factorial analysis (CFA) of MESSi displayed mediocre fit in the three countries. Comparing increasingly stringent models using multigroup confirmatory factor analyses indicated at least partial measurement invariance (metric invariance) by country for Morning Affect and Distinctness subscales...
2017: Chronobiology International
https://www.readbyqxmd.com/read/28045078/positive-association-between-physical-activity-and-per3-expression-in-older-adults
#15
Masaki Takahashi, Atsushi Haraguchi, Yu Tahara, Natsumi Aoki, Mayuko Fukazawa, Kumpei Tanisawa, Tomoko Ito, Takashi Nakaoka, Mitsuru Higuchi, Shigenobu Shibata
The circadian clock regulates many physiological functions including physical activity and feeding patterns. In addition, scheduled exercise and feeding themselves can affect the circadian clock. The purpose of the present study was to investigate the relationship between physical/feeding activity and expression of clock genes in hair follicle cells in older adults. Twenty adult men (age, 68 ± 7 years, mean ± SE) were examined in this cross-sectional study. Prior to hair follicle cell collection, the participants were asked to wear a uniaxial accelerometer for one week...
January 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/27992627/associations-between-%C3%AE-amyloid-kinetics-and-the-%C3%AE-amyloid-diurnal-pattern-in-the-central-nervous-system
#16
Brendan P Lucey, Kwasi G Mawuenyega, Bruce W Patterson, Donald L Elbert, Vitaliy Ovod, Tom Kasten, John C Morris, Randall J Bateman
Importance: Recent studies found that the concentration of amyloid-β (Aβ) fluctuates with the sleep-wake cycle. Although the amplitude of this day/night pattern attenuates with age and amyloid deposition, to our knowledge, the association of Aβ kinetics (ie, production, turnover, and clearance) with this oscillation has not been studied. Objective: To determine the association between Aβ kinetics, age, amyloid levels, and the Aβ day/night pattern in humans...
February 1, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/27967134/impact-of-time-delays-on-oscillatory-dynamics-of-interlinked-positive-and-negative-feedback-loops
#17
Bo Huang, Xinyu Tian, Feng Liu, Wei Wang
Interlinking a positive feedback loop (PFL) with a negative feedback loop (NFL) constitutes a typical motif in genetic networks, performing various functions in cell signaling. How time delay in feedback regulation affects the dynamics of such systems still remains unclear. Here, we investigate three systems of interlinked PFL and NFL with time delays: a synthetic genetic oscillator, a three-node circuit, and a simplified single-node model. The stability of steady states and the routes to oscillation in the single-node model are analyzed in detail...
November 2016: Physical Review. E
https://www.readbyqxmd.com/read/27888766/circadian-time-dependent-antioxidant-and-inflammatory-responses-to-acute-cadmium-exposure-in-the-brain-of-zebrafish
#18
Jia-Lang Zheng, Shuang-Shuang Yuan, Chang-Wen Wu, Zhen-Ming Lv, Ai-Yi Zhu
Up to date, little information is available on effects of circadian rhythm on metal-induced toxicity in fish. In this study, zebrafish were acutely exposed to 0.97mgL(-1) cadmium for 12h either at ZT0 (the light intensity began to reached maximum) or at ZT12 (light intensity began to reached minimum) to evaluate the temporal sensitivity of oxidative stress and inflammatory responses in the brain of zebrafish. Profiles of responses of some genes at mRNA, protein and activity levels were different between ZT0 and ZT12 in the normal water...
January 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/27884756/repeated-unpredictable-threats-without-harm-impair-spatial-working-memory-in-the-barnes-maze
#19
Diane J Kim, Nathan St Louis, Ralph A Molaro, Glenn T Hudson, Robert C Chorley, Brenda J Anderson
Psychological stressors elicit the anticipation of homeostatic challenge, whereas physical stressors are direct threats to homeostasis. Many rodent models of stress include both types of stressors, yet deficits, like those reported for working memory, are often attributed to psychological stress. To empirically test whether intermittent psychological stressors, such as repeated threats, are solely sufficient to impair spatial working memory, we developed a novel rodent model of stress that is restricted to the anticipation of threat, and free of direct physical challenge...
January 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/27883893/circadian-alterations-during-early-stages-of-alzheimer-s-disease-are-associated-with-aberrant-cycles-of-dna-methylation-in-bmal1
#20
Peter Cronin, Michael J McCarthy, Andrew S P Lim, David P Salmon, Douglas Galasko, Eliezer Masliah, Philip L De Jager, David A Bennett, Paula Desplats
INTRODUCTION: Circadian alterations are prevalent in Alzheimer's disease (AD) and may contribute to cognitive impairment, behavioral symptoms, and neurodegeneration. Epigenetic mechanisms regulate the circadian clock, and changes in DNA methylation have been reported in AD brains, but the pathways that mediate circadian deregulation in AD are incompletely understood. We hypothesized that aberrant DNA methylation may affect circadian rhythms in AD. METHODS: We investigated DNA methylation, transcription, and expression of BMAL1, a positive regulator of the circadian clock, in cultured fibroblasts and brain samples from two independent cohorts of aging and AD...
November 22, 2016: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
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