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https://www.readbyqxmd.com/read/29382900/seasonal-variation-in-nocturnal-home-blood-pressure-fall-the-nagahama-study
#1
Yasuharu Tabara, Takeshi Matsumoto, Kimihiko Murase, Shunsuke Nagashima, Toyohiro Hirai, Shinji Kosugi, Takeo Nakayama, Tomoko Wakamura, Kazuo Chin, Fumihiko Matsuda
Abnormalities in circadian blood pressure (BP) variation have been suggested to be associated with cardiovascular diseases and mortality. Factors affecting this variability need to be clarified to precisely evaluate the risk of circadian BP abnormalities. Given the seasonal differences in casual BP, it was hypothesized that nocturnal BP may also differ by season. Here, we aimed to clarify the seasonality of circadian BP variation, as well as the factors associated with this seasonality, in a large-scale general population (n = 4780)...
January 30, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29360812/domestic-light-at-night-and-breast-cancer-risk-a-prospective-analysis-of-105%C3%A2-000-uk-women-in-the-generations-study
#2
Louise E Johns, Michael E Jones, Minouk J Schoemaker, Emily McFadden, Alan Ashworth, Anthony J Swerdlow
BACKGROUND: Circadian disruption caused by exposure to light at night (LAN) has been proposed as a risk factor for breast cancer and a reason for secular increases in incidence. Studies to date have largely been ecological or case-control in design and findings have been mixed. METHODS: We investigated the relationship between LAN and breast cancer risk in the UK Generations Study. Bedroom light levels and sleeping patterns at age 20 and at study recruitment were obtained by questionnaire...
January 23, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29298348/computational-exploration-of-cis-regulatory-modules-in-rhythmic-expression-data-using-the-exploration-of-distinctive-cres-and-crms-edcc-and-crm-network-generator-cng-programs
#3
Pavlos Stephanos Bekiaris, Tobias Tekath, Dorothee Staiger, Selahattin Danisman
Understanding the effect of cis-regulatory elements (CRE) and clusters of CREs, which are called cis-regulatory modules (CRM), in eukaryotic gene expression is a challenge of computational biology. We developed two programs that allow simple, fast and reliable analysis of candidate CREs and CRMs that may affect specific gene expression and that determine positional features between individual CREs within a CRM. The first program, "Exploration of Distinctive CREs and CRMs" (EDCC), correlates candidate CREs and CRMs with specific gene expression patterns...
2018: PloS One
https://www.readbyqxmd.com/read/29143225/diurnal-regulation-of-the-floral-scent-emission-by-light-and-circadian-rhythm-in-the-phalaenopsis-orchids
#4
Yu-Chen Chuang, Ming-Chi Lee, Ya-Lan Chang, Wen-Huei Chen, Hong-Hwa Chen
BACKGROUND: Phalaenopsis bellina and its closely related species, P. violacea, emit linalool, geraniol and their derivatives as the predominant monoterpenes at the full-bloom stages. Geranyl diphosphate synthase (PbGDPS) is the key enzyme that converts precursors for monoterpene biosynthesis. Besides the monoterpenes being synthesized in concert with floral development stages, we noticed that the scent emission of P. bellina and P. violacea was detected mainly in the daytime. RESULTS: The monoterpenes of P...
November 15, 2017: Botanical Studies (Taipei, Taiwan)
https://www.readbyqxmd.com/read/29111783/would-you-say-yes-in-the-evening-time-of-day-effect-on-response-bias-in-four-types-of-working-memory-recognition-tasks
#5
Koryna Lewandowska, Barbara Wachowicz, Tadeusz Marek, Halszka Oginska, Magdalena Fafrowicz
Across a wide range of tasks, cognitive functioning is affected by circadian fluctuations. In this study, we investigated diurnal variations of working memory performance, taking into account not only hits and errors rates, but also sensitivity (d') and response bias (c) indexes (established by signal detection theory). Fifty-two healthy volunteers performed four experimental tasks twice - in the morning and in the evening (approximately 1 and 10 h after awakening). All tasks were based on Deese-Roediger-McDermott paradigm version dedicated to study working/short-term memory distortions...
November 7, 2017: Chronobiology International
https://www.readbyqxmd.com/read/29106308/sleep-quality-and-methylation-status-of-core-circadian-rhythm-genes-among-nurses-and-midwives
#6
Agnieszka Bukowska-Damska, Edyta Reszka, Pawel Kaluzny, Edyta Wieczorek, Monika Przybek, Shanbeh Zienolddiny, Beata Peplonska
ABSTARCT Poor sleep quality or sleep restriction is associated with sleepiness and concentration problems. Moreover, chronic sleep restriction may affect metabolism, hormone secretion patterns and inflammatory responses. Limited recent reports suggest a potential link between sleep deprivation and epigenetic effects such as changes in DNA methylation profiles. The aim of the present study was to assess the potential association between poor sleep quality or sleep duration and the levels of 5-methylcytosine in the promoter regions of PER1, PER2, PER3, BMAL1, CLOCK, CRY1 CRY2 and NPAS2 genes, taking into account rotating night work and chronotype as potential confounders or modifiers...
2017: Chronobiology International
https://www.readbyqxmd.com/read/29066952/the-sleep-wake-cycle-in-the-nicotinic-alpha-9-acetylcholine-receptor-subunit-knock-out-mice
#7
Natalia Madrid-López, Jorge Estrada, Javier Díaz, Alejandro Bassi, Paul H Délano, Adrián Ocampo-Garcés
There is a neural matrix controlling the sleep-wake cycle (SWC) embedded within high ranking integrative mechanisms in the central nervous system. Nicotinic alpha-9 acetylcholine receptor subunit (alpha-9 nAChR) participate in physiological processes occurring in sensory, endocrine and immune systems. There is a relationship between the SWC architecture, body homeostasis and sensory afferents so that disruption of afferent signaling is expected to affect the temporal organization of sleep and wake states. The analysis of the SWC of 9 nAChR knock-out animals may help to reveal the contribution of alpha-9 nAChR to sleep chronobiological determinants...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29056434/dim-light-melatonin-onset-and-affect-in-adolescents-with-an-evening-circadian-preference
#8
Michael R Dolsen, Allison G Harvey
PURPOSE: A shift toward an evening circadian preference and the onset of mood problems often occur during adolescence. Although these changes are linked to poorer outcomes, few studies have considered how positive and negative affect are related to the circadian rhythm during adolescence. This study examined the relationship between evening and morning affect ratings and dim light melatonin onset (DLMO), a measure of endogenous circadian rhythm. Age and sex were tested as moderators. METHODS: This study is based on a subset of 163 (94 female, age = 14...
October 19, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28992598/global-transcriptomic-analysis-of-zebrafish-in-response-to-embryonic-exposure-to-three-antidepressants-amitriptyline-fluoxetine-and-mianserin
#9
Minghong Wu, Shuai Liu, Lei Hu, Haidong Qu, Chenyuan Pan, Penghui Lei, Yingjia Shen, Ming Yang
Antidepressants are among the most commonly detected pharmaceuticals in aqueous systems, and, as emerging organic pollutants, may exert negative effects on non-target aquatic organisms. Previously, it has been revealed that antidepressant exposure significantly inhibits the growth and development of fish during their early developmental stages. Thus, in the present study, we aimed to identify and compare the underlying mechanisms of action of different antidepressants at the transcriptional level using zebrafish (Danio rerio) embryos...
September 28, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28963505/slow-wave-sleep-is-controlled-by-a-subset-of-nucleus-accumbens-core-neurons-in-mice
#10
Yo Oishi, Qi Xu, Lu Wang, Bin-Jia Zhang, Koji Takahashi, Yohko Takata, Yan-Jia Luo, Yoan Cherasse, Serge N Schiffmann, Alban de Kerchove d'Exaerde, Yoshihiro Urade, Wei-Min Qu, Zhi-Li Huang, Michael Lazarus
Sleep control is ascribed to a two-process model, a widely accepted concept that posits homoeostatic drive and a circadian process as the major sleep-regulating factors. Cognitive and emotional factors also influence sleep-wake behaviour; however, the precise circuit mechanisms underlying their effects on sleep control are unknown. Previous studies suggest that adenosine has a role affecting behavioural arousal in the nucleus accumbens (NAc), a brain area critical for reinforcement and reward. Here, we show that chemogenetic or optogenetic activation of excitatory adenosine A2A receptor-expressing indirect pathway neurons in the core region of the NAc strongly induces slow-wave sleep...
September 29, 2017: Nature Communications
https://www.readbyqxmd.com/read/28956858/circadian-rhythms-of-retinomotor-movement-in-a-marine-megapredator-the-atlantic-tarpon-megalops-atlanticus
#11
Kristin L Kopperud, Michael S Grace
Many ecologically and economically important marine fish species worldwide spend portions of their lives in coastal regions that are increasingly inundated by artificial light at night. However, while extensive research illustrates the harmful effects of inappropriate light exposure on biological timing in humans, rodents and birds, comparable studies on marine fish are virtually nonexistent. This study aimed to assess the effects of light on biological clock function in the marine fish retina using the Atlantic tarpon (Megalops atlanticus) as a model...
September 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28939842/overexpression-of-ovine-aanat-and-hiomt-genes-in-switchgrass-leads-to-improved-growth-performance-and-salt-tolerance
#12
Yan-Hua Huang, Si-Jia Liu, Shan Yuan, Cong Guan, Dan-Yang Tian, Xin Cui, Yun-Wei Zhang, Fu-Yu Yang
Melatonin is a well-known bioactive molecule with an array of health-promoting properties. Here, we detected the physiological function of melatonin in transgenic switchgrass overexpressing the homologous sheep arylalkylamine N-acetyltransferase and hydroxyindole O-methyltransferase genes, which catalyze the last two steps of melatonin synthesis. Compared to the wild-type (WT) and transgenic control (EV, expressing the empty vector only) plants, the transgenic switchgrass showed higher melatonin levels. Melatonin was detected in almost all switchgrass tissues, and relatively higher levels were detected in the roots and stems...
September 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28933566/validation-of-the-messi-among-adult-workers-and-young-students-general-health-and-personality-correlates
#13
Juan F Díaz-Morales, Christoph Randler, Arturo Arrona-Palacios, Ana Adan
The aim of this study was to provide validity for the Spanish version of the Morningness-Eveningness-Stability Scale - improved (MESSi), a novel evolved assessment of circadian typology which considers the subjective phase and amplitude by morning affect (MA), eveningness (EV) and distinctness (DI; subjective amplitude) sub-scales. Convergence validity of the MESSi with the reduced Morningness-Eveningness Questionnaire (rMEQ) and relationships with the General Health Questionnaire (GHQ-12) and sensitivity to reward and punishment (SR and SP) were analyzed...
September 21, 2017: Chronobiology International
https://www.readbyqxmd.com/read/28928461/time-dependent-effects-of-ipragliflozin-on-behaviour-and-energy-homeostasis-in-normal-and-type-2-diabetic-rats-continuous-glucose-telemetry-analysis
#14
Hiroyuki Iuchi, Masaya Sakamoto, Daisuke Matsutani, Hirofumi Suzuki, Yosuke Kayama, Norihiko Takeda, Susumu Minamisawa, Kazunori Utsunomiya
Sodium-glucose cotransporter 2 (SGLT2) inhibitors are oral antidiabetic drugs that promote urinary glucose excretion. Conversely, they cause behavioural changes, such as hyperphagia, that result in a positive energy balance. The relationship between energy homeostasis and SGLT2 inhibitors-induced behavioural changes remains unclear. Here we show that ipragliflozin, a SGLT2 inhibitor, time-dependently affects behaviour and enhances energy expenditure in normal and type 2 diabetic Goto-Kakizaki (GK) rats, using continuous glucose telemetry...
September 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28926419/peduncular-hallucinosis-and-autonomic-dysfunction-in-anti-aquaporin-4-antibody-syndrome
#15
Renee Berry, Peter K Panegyres
Neuromyelitis optica is a rare, severe inflammatory demyelinating disease of the central nervous system, previously described as affecting only the optic nerve and spinal cord. Since the discovery of a highly specific autoantibody, anti-aquaporin-4, lesions are now recognized outside these regions. We report a man with severe, debilitating symptoms resulting from a symptomatic lesion within the diencephalon, manifesting with abnormal circadian rhythms, autonomic dysfunction, behavioral disturbance, and complex visual hallucinations...
September 2017: Cognitive and Behavioral Neurology: Official Journal of the Society for Behavioral and Cognitive Neurology
https://www.readbyqxmd.com/read/28910542/effect-of-monochromatic-light-on-circadian-rhythmic-expression-of-clock-genes-and-arylalkylamine-n-acetyltransferase-in-chick-retina
#16
Jing Cao, Jiang Bian, Zixu Wang, Yulan Dong, Yaoxing Chen
Birds have more developed visual function. They not only have the ability to detect light and darkness but also have the color vision. Previous study showed that monochromatic light influenced avian physiological processes, which were controlled by clock genes. Therefore, bird's eye is a good model to studying the impact of color of light on circadian rhythms. Avian retina is one of the most important central oscillations. The study was designed to investigate the effect of color of light on the expression of clock genes and arylalkylamine N-acetyltransferase (Aanat) mRNA expression in chick retina...
2017: Chronobiology International
https://www.readbyqxmd.com/read/28886965/circadian-and-economic-factors-affect-food-acquisition-in-rats-restricted-to-discrete-feeding-opportunities
#17
Dulce M Minaya, Kimberly L Robertson, Neil E Rowland
The purpose of this study is to examine aspects of operant behavior-modeled economic choice for food in rats in closed economy protocols in which food is available for only a few discrete times per daily 23-h session, designed to emulate clustering of human food intake into meals. In the first experiment, rats performed lever press responses for food pellets in an ascending series of ratios or fixed unit prices (FUP) when food was available for four 40-min food opportunities (FO) per day. Daily intake at low FUP was comparable to ad libitum intakes...
November 1, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28871236/non-visual-photopigments-effects-of-constant-light-emitting-diode-light-exposure-on-the-inner-retina-of-wistar-rats
#18
María M Benedetto, Mario E Guido, María A Contin
The retina is part of the central nervous system specially adapted to capture light photons and transmit this information to the brain through photosensitive retinal cells involved in visual and non-visual activities. However, excessive light exposure may accelerate genetic retinal diseases or induce photoreceptor cell (PRC) death, finally leading to retinal degeneration (RD). Light pollution (LP) caused by the characteristic use of artificial light in modern day life may accelerate degenerative diseases or promote RD and circadian desynchrony...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28842409/time-of-day-differences-in-neural-reward-functioning-in-healthy-young-men
#19
Jamie E M Byrne, Matthew E Hughes, Susan L Rossell, Sheri L Johnson, Greg Murray
Reward function appears to be modulated by the circadian system, but little is known about the neural basis of this interaction. Previous research suggests that the neural reward response may be different in the afternoon; however, the direction of this effect is contentious. Reward response may follow the diurnal rhythm in self-reported positive affect, peaking in the early afternoon. An alternative is that daily reward response represents a type of prediction error, with neural reward activation relatively high at times of day when rewards are unexpected (i...
September 13, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28801530/rhythmic-behavior-is-controlled-by-the-srm160-splicing-factor-in-drosophila-melanogaster
#20
Esteban J Beckwith, Carlos E Hernando, Sofía Polcowñuk, Agustina P Bertolin, Estefania Mancini, M Fernanda Ceriani, Marcelo J Yanovsky
Circadian clocks organize the metabolism, physiology, and behavior of organisms throughout the day-night cycle by controlling daily rhythms in gene expression at the transcriptional and post-transcriptional levels. While many transcription factors underlying circadian oscillations are known, the splicing factors that modulate these rhythms remain largely unexplored. A genome-wide assessment of the alterations of gene expression in a null mutant of the alternative splicing regulator SR-related matrix protein of 160 kDa (SRm160) revealed the extent to which alternative splicing impacts on behavior-related genes...
October 2017: Genetics
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