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https://www.readbyqxmd.com/read/29626158/deubiquitinating-enzyme-usp9x-regulates-cellular-clock-function-by-modulating-the-ubiquitination-and-degradation-of-a-core-circadian-protein-bmal1
#1
Yang Zhang, Chunyan Duan, Jing Yang, Suping Chen, Qing Liu, Liang Zhou, Zhengyun Huang, Ying Xu, Guoqiang Xu
Living organisms on the earth maintain a roughly 24 h circadian rhythm, which is regulated by circadian clock genes as well as their protein products. Post-translational modifications of core clock proteins could affect the circadian behavior. Although ubiquitination of core clock proteins was studied extensively, the reverse process, deubiquitination, has only begun to unfold and the role of this regulation on circadian function is not completely understood. Here, we use affinity purification and mass spectrometry analysis to identify probable ubiquitin carboxyl-terminal hydrolase FAF-X (USP9X) as an interacting protein of the core clock protein aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL or BMAL1)...
April 6, 2018: Biochemical Journal
https://www.readbyqxmd.com/read/29617644/a-transcriptional-circuit-filters-oscillating-circadian-hormonal-inputs-to-regulate-fat-cell-differentiation
#2
Zahra Bahrami-Nejad, Michael L Zhao, Stefan Tholen, Devon Hunerdosse, Karen E Tkach, Sabine van Schie, Mingyu Chung, Mary N Teruel
Glucocorticoid and other adipogenic hormones are secreted in mammals in circadian oscillations. Loss of this circadian oscillation pattern correlates with obesity in humans, raising the intriguing question of how hormone secretion dynamics affect adipocyte differentiation. Using live, single-cell imaging of the key adipogenic transcription factors CEBPB and PPARG, endogenously tagged with fluorescent proteins, we show that pulsatile circadian hormone stimuli are rejected by the adipocyte differentiation control system...
April 3, 2018: Cell Metabolism
https://www.readbyqxmd.com/read/29543518/the-heart%C3%A2-s-rhythm-n-blues-sex-differences-in-circadian-variation-patterns-of-vagal-activity-vary-by-depressive-symptoms-in-predominantly-healthy-employees
#3
Marc N Jarczok, Corina Aguilar-Raab, Julian Koenig, Michael Kaess, Jeremy C Borniger, Randy J Nelson, Martica Hall, Beate Ditzen, Julian F Thayer, Joachim E Fischer
INTRODUCTION: Successful regulation of emotional states is positively associated to mental health, while difficulties in regulating emotions are negatively associated to overall mental health and in particular associated with anxiety or depression symptoms. A key structure associated to socio-emotional regulatory processes is the central autonomic network. Activity in this structure is associated to vagal activity can be indexed noninvasively and simply by measures of peripheral cardiac autonomic modulations such as heart rate variability...
March 15, 2018: Chronobiology International
https://www.readbyqxmd.com/read/29543122/the-influence-of-circadian-variation-on-aetiological-markers-of-ankle-injury
#4
Chris Brogden, Kelly Marrin, Richard Page, Matt Greig
CONTEXT: Clinical and functional assessments are performed regularly in sporting environments to screen for performance deficits and injury risk. Circadian rhythms have been demonstrated to affect human performance, however the influence of time of day on a battery of multiple ankle injury risk factors has yet to be established within athletic populations. OBJECTIVES: To investigate the influence of circadian variation on a battery of tests, used to screen for ankle aetiological risk factors...
March 15, 2018: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/29524919/placental-circadian-pathway-methylation-and-in-utero-exposure-to-fine-particle-air-pollution
#5
Tim S Nawrot, Nelly D Saenen, Julie Schenk, Bram G Janssen, Valeria Motta, Letizia Tarantini, Bianca Cox, Wouter Lefebvre, Charlotte Vanpoucke, Cristina Maggioni, Valentina Bollati
In mammals, a central clock maintains the daily rhythm in accordance with the external environment. At the molecular level, the circadian rhythm is maintained by epigenetic regulation of the Circadian pathway. Here, we tested the role of particulate matter with an aerodynamic diameter ≤ 2.5 μm (PM2.5 ) exposure during gestational life on human placental Circadian pathway methylation, as an important molecular target for healthy development. In 407 newborns, we quantified placental methylation of CpG sites within the promoter regions of the following genes: CLOCK, BMAL1, NPAS2, CRY1-2 and PER1-3 using bisulfite-PCR-pyrosequencing...
March 7, 2018: Environment International
https://www.readbyqxmd.com/read/29516223/a-circadian-rhythm-related-mtnr1b-genetic-variant-modulates-the-effect-of-weight-loss-diets-on-changes-in-adiposity-and-body-composition-the-pounds-lost-trial
#6
Leticia Goni, Dianjianyi Sun, Yoriko Heianza, Tiange Wang, Tao Huang, J Alfredo Martínez, Xiaoyun Shang, George A Bray, Steven R Smith, Frank M Sacks, Lu Qi
PURPOSE: A common variant of the melatonin receptor 1B (MTNR1B) gene has been related to increased signaling of melatonin, a hormone previously associated with body fatness mainly through effects on energy metabolism. We examined whether the MTNR1B variant affects changes of body fatness and composition in response to a dietary weight loss intervention. METHODS: The MTNR1B rs10830963 variant was genotyped for 722 overweight and obese individuals, who were randomly assigned to one of four diets varying in macronutrient composition...
March 7, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29504798/environmental-light-and-time-of-day-modulate-subjective-liking-and-wanting
#7
Jacob Itzhacki, Bart H W Te Lindert, Wisse P van der Meijden, Morten L Kringelbach, Jorge Mendoza, Eus J W Van Someren
Several studies demonstrated effects of light on affect via projections from the retina of the eye to the circadian clock or via projections to areas involved in mood and reward. Few field studies investigated how naturally fluctuating light levels affect positive and negative mood in everyday life, but none addressed two key components of the reward system: wanting and liking. To elucidate diurnal profiles and immediate effects of dynamically changing light intensity in everyday life, subjective wanting and liking were assessed using experience sampling, while continuously monitoring environmental illuminance...
March 5, 2018: Emotion
https://www.readbyqxmd.com/read/29382900/seasonal-variation-in-nocturnal-home-blood-pressure-fall-the-nagahama-study
#8
Yasuharu Tabara, Takeshi Matsumoto, Kimihiko Murase, Shunsuke Nagashima, Toyohiro Hirai, Shinji Kosugi, Takeo Nakayama, Tomoko Wakamura, Kazuo Chin, Fumihiko Matsuda
Abnormalities in circadian blood pressure (BP) variation have been suggested to be associated with cardiovascular diseases and mortality. Factors affecting this variability need to be clarified to precisely evaluate the risk of circadian BP abnormalities. Given the seasonal differences in casual BP, it was hypothesized that nocturnal BP may also differ by season. Here, we aimed to clarify the seasonality of circadian BP variation, as well as the factors associated with this seasonality, in a large-scale general population (n = 4780)...
March 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29360812/domestic-light-at-night-and-breast-cancer-risk-a-prospective-analysis-of-105%C3%A2-000-uk-women-in-the-generations-study
#9
Louise E Johns, Michael E Jones, Minouk J Schoemaker, Emily McFadden, Alan Ashworth, Anthony J Swerdlow
BACKGROUND: Circadian disruption caused by exposure to light at night (LAN) has been proposed as a risk factor for breast cancer and a reason for secular increases in incidence. Studies to date have largely been ecological or case-control in design and findings have been mixed. METHODS: We investigated the relationship between LAN and breast cancer risk in the UK Generations Study. Bedroom light levels and sleeping patterns at age 20 and at study recruitment were obtained by questionnaire...
January 23, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29298348/computational-exploration-of-cis-regulatory-modules-in-rhythmic-expression-data-using-the-exploration-of-distinctive-cres-and-crms-edcc-and-crm-network-generator-cng-programs
#10
Pavlos Stephanos Bekiaris, Tobias Tekath, Dorothee Staiger, Selahattin Danisman
Understanding the effect of cis-regulatory elements (CRE) and clusters of CREs, which are called cis-regulatory modules (CRM), in eukaryotic gene expression is a challenge of computational biology. We developed two programs that allow simple, fast and reliable analysis of candidate CREs and CRMs that may affect specific gene expression and that determine positional features between individual CREs within a CRM. The first program, "Exploration of Distinctive CREs and CRMs" (EDCC), correlates candidate CREs and CRMs with specific gene expression patterns...
2018: PloS One
https://www.readbyqxmd.com/read/29143225/diurnal-regulation-of-the-floral-scent-emission-by-light-and-circadian-rhythm-in-the-phalaenopsis-orchids
#11
Yu-Chen Chuang, Ming-Chi Lee, Ya-Lan Chang, Wen-Huei Chen, Hong-Hwa Chen
BACKGROUND: Phalaenopsis bellina and its closely related species, P. violacea, emit linalool, geraniol and their derivatives as the predominant monoterpenes at the full-bloom stages. Geranyl diphosphate synthase (PbGDPS) is the key enzyme that converts precursors for monoterpene biosynthesis. Besides the monoterpenes being synthesized in concert with floral development stages, we noticed that the scent emission of P. bellina and P. violacea was detected mainly in the daytime. RESULTS: The monoterpenes of P...
November 15, 2017: Botanical Studies (Taipei, Taiwan)
https://www.readbyqxmd.com/read/29111783/would-you-say-yes-in-the-evening-time-of-day-effect-on-response-bias-in-four-types-of-working-memory-recognition-tasks
#12
Koryna Lewandowska, Barbara Wachowicz, Tadeusz Marek, Halszka Oginska, Magdalena Fafrowicz
Across a wide range of tasks, cognitive functioning is affected by circadian fluctuations. In this study, we investigated diurnal variations of working memory performance, taking into account not only hits and errors rates, but also sensitivity (d') and response bias (c) indexes (established by signal detection theory). Fifty-two healthy volunteers performed four experimental tasks twice - in the morning and in the evening (approximately 1 and 10 h after awakening). All tasks were based on Deese-Roediger-McDermott paradigm version dedicated to study working/short-term memory distortions...
November 7, 2017: Chronobiology International
https://www.readbyqxmd.com/read/29106308/sleep-quality-and-methylation-status-of-core-circadian-rhythm-genes-among-nurses-and-midwives
#13
Agnieszka Bukowska-Damska, Edyta Reszka, Pawel Kaluzny, Edyta Wieczorek, Monika Przybek, Shanbeh Zienolddiny, Beata Peplonska
ABSTARCT Poor sleep quality or sleep restriction is associated with sleepiness and concentration problems. Moreover, chronic sleep restriction may affect metabolism, hormone secretion patterns and inflammatory responses. Limited recent reports suggest a potential link between sleep deprivation and epigenetic effects such as changes in DNA methylation profiles. The aim of the present study was to assess the potential association between poor sleep quality or sleep duration and the levels of 5-methylcytosine in the promoter regions of PER1, PER2, PER3, BMAL1, CLOCK, CRY1 CRY2 and NPAS2 genes, taking into account rotating night work and chronotype as potential confounders or modifiers...
2017: Chronobiology International
https://www.readbyqxmd.com/read/29066952/the-sleep-wake-cycle-in-the-nicotinic-alpha-9-acetylcholine-receptor-subunit-knock-out-mice
#14
Natalia Madrid-López, Jorge Estrada, Javier Díaz, Alejandro Bassi, Paul H Délano, Adrián Ocampo-Garcés
There is a neural matrix controlling the sleep-wake cycle (SWC) embedded within high ranking integrative mechanisms in the central nervous system. Nicotinic alpha-9 acetylcholine receptor subunit (alpha-9 nAChR) participate in physiological processes occurring in sensory, endocrine and immune systems. There is a relationship between the SWC architecture, body homeostasis and sensory afferents so that disruption of afferent signaling is expected to affect the temporal organization of sleep and wake states. The analysis of the SWC of 9 nAChR knock-out animals may help to reveal the contribution of alpha-9 nAChR to sleep chronobiological determinants...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29056434/dim-light-melatonin-onset-and-affect-in-adolescents-with-an-evening-circadian-preference
#15
Michael R Dolsen, Allison G Harvey
PURPOSE: A shift toward an evening circadian preference and the onset of mood problems often occur during adolescence. Although these changes are linked to poorer outcomes, few studies have considered how positive and negative affect are related to the circadian rhythm during adolescence. This study examined the relationship between evening and morning affect ratings and dim light melatonin onset (DLMO), a measure of endogenous circadian rhythm. Age and sex were tested as moderators. METHODS: This study is based on a subset of 163 (94 female, age = 14...
January 2018: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28992598/global-transcriptomic-analysis-of-zebrafish-in-response-to-embryonic-exposure-to-three-antidepressants-amitriptyline-fluoxetine-and-mianserin
#16
Minghong Wu, Shuai Liu, Lei Hu, Haidong Qu, Chenyuan Pan, Penghui Lei, Yingjia Shen, Ming Yang
Antidepressants are among the most commonly detected pharmaceuticals in aqueous systems, and, as emerging organic pollutants, may exert negative effects on non-target aquatic organisms. Previously, it has been revealed that antidepressant exposure significantly inhibits the growth and development of fish during their early developmental stages. Thus, in the present study, we aimed to identify and compare the underlying mechanisms of action of different antidepressants at the transcriptional level using zebrafish (Danio rerio) embryos...
September 28, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28963505/slow-wave-sleep-is-controlled-by-a-subset-of-nucleus-accumbens-core-neurons-in-mice
#17
Yo Oishi, Qi Xu, Lu Wang, Bin-Jia Zhang, Koji Takahashi, Yohko Takata, Yan-Jia Luo, Yoan Cherasse, Serge N Schiffmann, Alban de Kerchove d'Exaerde, Yoshihiro Urade, Wei-Min Qu, Zhi-Li Huang, Michael Lazarus
Sleep control is ascribed to a two-process model, a widely accepted concept that posits homoeostatic drive and a circadian process as the major sleep-regulating factors. Cognitive and emotional factors also influence sleep-wake behaviour; however, the precise circuit mechanisms underlying their effects on sleep control are unknown. Previous studies suggest that adenosine has a role affecting behavioural arousal in the nucleus accumbens (NAc), a brain area critical for reinforcement and reward. Here, we show that chemogenetic or optogenetic activation of excitatory adenosine A2A receptor-expressing indirect pathway neurons in the core region of the NAc strongly induces slow-wave sleep...
September 29, 2017: Nature Communications
https://www.readbyqxmd.com/read/28956858/circadian-rhythms-of-retinomotor-movement-in-a-marine-megapredator-the-atlantic-tarpon-megalops-atlanticus
#18
Kristin L Kopperud, Michael S Grace
Many ecologically and economically important marine fish species worldwide spend portions of their lives in coastal regions that are increasingly inundated by artificial light at night. However, while extensive research illustrates the harmful effects of inappropriate light exposure on biological timing in humans, rodents and birds, comparable studies on marine fish are virtually nonexistent. This study aimed to assess the effects of light on biological clock function in the marine fish retina using the Atlantic tarpon (Megalops atlanticus) as a model...
September 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28939842/overexpression-of-ovine-aanat-and-hiomt-genes-in-switchgrass-leads-to-improved-growth-performance-and-salt-tolerance
#19
Yan-Hua Huang, Si-Jia Liu, Shan Yuan, Cong Guan, Dan-Yang Tian, Xin Cui, Yun-Wei Zhang, Fu-Yu Yang
Melatonin is a well-known bioactive molecule with an array of health-promoting properties. Here, we detected the physiological function of melatonin in transgenic switchgrass overexpressing the homologous sheep arylalkylamine N-acetyltransferase and hydroxyindole O-methyltransferase genes, which catalyze the last two steps of melatonin synthesis. Compared to the wild-type (WT) and transgenic control (EV, expressing the empty vector only) plants, the transgenic switchgrass showed higher melatonin levels. Melatonin was detected in almost all switchgrass tissues, and relatively higher levels were detected in the roots and stems...
September 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28933566/validation-of-the-messi-among-adult-workers-and-young-students-general-health-and-personality-correlates
#20
Juan F Díaz-Morales, Christoph Randler, Arturo Arrona-Palacios, Ana Adan
The aim of this study was to provide validity for the Spanish version of the Morningness-Eveningness-Stability Scale - improved (MESSi), a novel evolved assessment of circadian typology which considers the subjective phase and amplitude by morning affect (MA), eveningness (EV) and distinctness (DI; subjective amplitude) sub-scales. Convergence validity of the MESSi with the reduced Morningness-Eveningness Questionnaire (rMEQ) and relationships with the General Health Questionnaire (GHQ-12) and sensitivity to reward and punishment (SR and SP) were analyzed...
2017: Chronobiology International
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