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https://www.readbyqxmd.com/read/28228130/transcriptome-of-the-floral-transition-in-rosa-chinensis-old-blush
#1
Xuelian Guo, Chao Yu, Le Luo, Huihua Wan, Ni Zhen, Tingliang Xu, Jiongrui Tan, Huitang Pan, Qixiang Zhang
BACKGROUND: The floral transition plays a vital role in the life of ornamental plants. Despite progress in model plants, the molecular mechanisms of flowering regulation remain unknown in perennial plants. Rosa chinensis 'Old Blush' is a unique plant that can flower continuously year-round. In this study, gene expression profiles associated with the flowering transition were comprehensively analyzed during floral transition in the rose. RESULTS: According to the transcriptomic profiles, 85,663 unigenes and 1,637 differentially expressed genes (DEGs) were identified, among which 32 unigenes were involved in the circadian clock, sugar metabolism, hormone, and autonomous pathways...
February 23, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28154744/environmental-factors-influencing-biological-rhythms-in-newborns-from-neonatal-intensive-care-units-to-home
#2
Clarissa Bueno, Luiz Menna-Barreto
Photic and non-photic environmental factors are suggested to modulate the development of circadian rhythms in infants. Our aim is to evaluate the development of biological rhythms (circadian or ultradian) in newborns in transition from Neonatal Intensive Care Units (NICU) to home and along the first 6 months of life, to identify masking and entraining environment factors along development. Ten newborns were evaluated in their last week inside the NICU and in the first week after being delivered home; 6 babies were also followed until 6 months of corrected age...
October 2016: Sleep Science
https://www.readbyqxmd.com/read/28060525/diurnal-rhythms-in-psychological-reward-functioning-in-healthy-young-men-wanting-liking-and-learning
#3
Jamie E M Byrne, Greg Murray
A range of evidence suggests that human reward functioning is partly driven by the endogenous circadian system, generating 24-hour rhythms in behavioural measures of reward activation. Reward functioning is multifaceted but literature to date is largely limited to measures of self-reported positive mood states. The aim of this study was to advance the field by testing for hypothesised diurnal variation in previously unexplored components of psychological reward: 'wanting', liking, and learning using subjective and behavioural measures...
2017: Chronobiology International
https://www.readbyqxmd.com/read/28055262/cross-cultural-validity-of-morningness-eveningness-stability-scale-improved-messi-in-iran-spain-and-germany
#4
Arash Rahafar, Christoph Randler, Juan F Díaz-Morales, Ali Kasaeian, Zeinab Heidari
Morningness-Eveningness Stability Scale improved (MESSi) is a newly constructed measure to assess circadian types and amplitude. In this study, we applied this measure to participants from three different countries: Germany, Spain and Iran. Confirmatory factorial analysis (CFA) of MESSi displayed mediocre fit in the three countries. Comparing increasingly stringent models using multigroup confirmatory factor analyses indicated at least partial measurement invariance (metric invariance) by country for Morning Affect and Distinctness subscales...
2017: Chronobiology International
https://www.readbyqxmd.com/read/28045078/positive-association-between-physical-activity-and-per3-expression-in-older-adults
#5
Masaki Takahashi, Atsushi Haraguchi, Yu Tahara, Natsumi Aoki, Mayuko Fukazawa, Kumpei Tanisawa, Tomoko Ito, Takashi Nakaoka, Mitsuru Higuchi, Shigenobu Shibata
The circadian clock regulates many physiological functions including physical activity and feeding patterns. In addition, scheduled exercise and feeding themselves can affect the circadian clock. The purpose of the present study was to investigate the relationship between physical/feeding activity and expression of clock genes in hair follicle cells in older adults. Twenty adult men (age, 68 ± 7 years, mean ± SE) were examined in this cross-sectional study. Prior to hair follicle cell collection, the participants were asked to wear a uniaxial accelerometer for one week...
January 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/27992627/associations-between-%C3%AE-amyloid-kinetics-and-the-%C3%AE-amyloid-diurnal-pattern-in-the-central-nervous-system
#6
Brendan P Lucey, Kwasi G Mawuenyega, Bruce W Patterson, Donald L Elbert, Vitaliy Ovod, Tom Kasten, John C Morris, Randall J Bateman
Importance: Recent studies found that the concentration of amyloid-β (Aβ) fluctuates with the sleep-wake cycle. Although the amplitude of this day/night pattern attenuates with age and amyloid deposition, to our knowledge, the association of Aβ kinetics (ie, production, turnover, and clearance) with this oscillation has not been studied. Objective: To determine the association between Aβ kinetics, age, amyloid levels, and the Aβ day/night pattern in humans...
February 1, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/27967134/impact-of-time-delays-on-oscillatory-dynamics-of-interlinked-positive-and-negative-feedback-loops
#7
Bo Huang, Xinyu Tian, Feng Liu, Wei Wang
Interlinking a positive feedback loop (PFL) with a negative feedback loop (NFL) constitutes a typical motif in genetic networks, performing various functions in cell signaling. How time delay in feedback regulation affects the dynamics of such systems still remains unclear. Here, we investigate three systems of interlinked PFL and NFL with time delays: a synthetic genetic oscillator, a three-node circuit, and a simplified single-node model. The stability of steady states and the routes to oscillation in the single-node model are analyzed in detail...
November 2016: Physical Review. E
https://www.readbyqxmd.com/read/27888766/circadian-time-dependent-antioxidant-and-inflammatory-responses-to-acute-cadmium-exposure-in-the-brain-of-zebrafish
#8
Jia-Lang Zheng, Shuang-Shuang Yuan, Chang-Wen Wu, Zhen-Ming Lv, Ai-Yi Zhu
Up to date, little information is available on effects of circadian rhythm on metal-induced toxicity in fish. In this study, zebrafish were acutely exposed to 0.97mgL(-1) cadmium for 12h either at ZT0 (the light intensity began to reached maximum) or at ZT12 (light intensity began to reached minimum) to evaluate the temporal sensitivity of oxidative stress and inflammatory responses in the brain of zebrafish. Profiles of responses of some genes at mRNA, protein and activity levels were different between ZT0 and ZT12 in the normal water...
January 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/27884756/repeated-unpredictable-threats-without-harm-impair-spatial-working-memory-in-the-barnes-maze
#9
Diane J Kim, Nathan St Louis, Ralph A Molaro, Glenn T Hudson, Robert C Chorley, Brenda J Anderson
Psychological stressors elicit the anticipation of homeostatic challenge, whereas physical stressors are direct threats to homeostasis. Many rodent models of stress include both types of stressors, yet deficits, like those reported for working memory, are often attributed to psychological stress. To empirically test whether intermittent psychological stressors, such as repeated threats, are solely sufficient to impair spatial working memory, we developed a novel rodent model of stress that is restricted to the anticipation of threat, and free of direct physical challenge...
January 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/27883893/circadian-alterations-during-early-stages-of-alzheimer-s-disease-are-associated-with-aberrant-cycles-of-dna-methylation-in-bmal1
#10
Peter Cronin, Michael J McCarthy, Andrew S P Lim, David P Salmon, Douglas Galasko, Eliezer Masliah, Philip L De Jager, David A Bennett, Paula Desplats
INTRODUCTION: Circadian alterations are prevalent in Alzheimer's disease (AD) and may contribute to cognitive impairment, behavioral symptoms, and neurodegeneration. Epigenetic mechanisms regulate the circadian clock, and changes in DNA methylation have been reported in AD brains, but the pathways that mediate circadian deregulation in AD are incompletely understood. We hypothesized that aberrant DNA methylation may affect circadian rhythms in AD. METHODS: We investigated DNA methylation, transcription, and expression of BMAL1, a positive regulator of the circadian clock, in cultured fibroblasts and brain samples from two independent cohorts of aging and AD...
November 22, 2016: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/27837007/blue-light-and-low-temperature-regulated-cor27-and-cor28-play-roles-in-the-arabidopsis-circadian-clock
#11
Xu Li, Dingbang Ma, Sheen X Lu, Xinyi Hu, Rongfeng Huang, Tong Liang, Tongda Xu, Elaine M Tobin, Hongtao Liu
Light and temperature are two key environmental signals that profoundly affect plant growth and development, but underlying molecular mechanisms of how light and temperature signals affect the circadian clock are largely unknown. Here, we report that COR27 and COR28 are regulated not only by low temperatures but also by light signals. COR27 and COR28 are negative regulators of freezing tolerance but positive regulators of flowering, possibly representing a trade-off between freezing tolerance and flowering...
November 2016: Plant Cell
https://www.readbyqxmd.com/read/27821487/circadian-clock-gene-bmal1-inhibits-tumorigenesis-and-increases-paclitaxel-sensitivity-in-tongue-squamous-cell-carcinoma
#12
Qingming Tang, Bo Cheng, Mengru Xie, Yatao Chen, Jiajia Zhao, Xin Zhou, Lili Chen
Circadian clock genes regulate cancer development and chemotherapy susceptibility. Accordingly, chronotherapy based on circadian phenotypes might be applied to improve therapeutic efficacy. In this study, we investigated whether the circadian clock gene Bmal1 inhibited tumor development and increased paclitaxel sensitivity in tongue squamous cell carcinoma (TSCC). Bmal1 expression was downregulated and its rhythmic pattern of expression was affected in TSCC samples and cell lines. Ectopic Bmal1 inhibited cell proliferation, migration and invasion in vitro, and tumor growth in mouse xenograft models of TSCC...
January 15, 2017: Cancer Research
https://www.readbyqxmd.com/read/27736199/morningness-eveningness-and-affective-temperaments-assessed-by-the-temperament-evaluation-of-memphis-pisa-and-san-diego-autoquestionnaire-temps-a
#13
Adrian Andrzej Chrobak, Anna Tereszko, Daria Dembinska-Krajewska, Aleksandra Arciszewska, Marcin Siwek, Dominika Dudek, Janusz Rybakowski
Chronotype is a stable trait presenting one's circardian preference. Since chronotype disturbances are common in patients with affective disorders, our aim is to evaluate chronotypes related to affective temperaments, measured with the temperament evaluation of Memphis, Pisa and San Diego-Autoquestionnaire (TEMPS-A). The study included 618 subjects (151 men and 467 women) within the framework of web-based design. They all fulfilled a questionnaire, consisting of the Composite Scale of Morningness (CSM), Sleep Wake Pattern Assessment Questionnaire (SWPAQ), and the TEMPS-A scale...
2017: Chronobiology International
https://www.readbyqxmd.com/read/27615061/4-hydroxyisophthalic-acid-from-decalepis-hamiltonii-rescues-the-neurobehavioral-deficit-in-transgenic-drosophila-model-of-taupathies
#14
Mohammad Haddadi, Samaneh Reiszadeh Jahromi, Upendra Nongthomba, T Shivanandappa, S R Ramesh
Oxidative stress is one of the major etiological factors implicated in pathogenesis of neurodegenerative diseases. Since neurons are more sensitive to oxidative damage there is an increasing interest in developing novel antioxidant therapies, especially herbal preparations due to their safety profile and high efficiency. In this regard, the neuroprotective potential of a novel antioxidant compound, 4-hydroxyisophthalic acid (4-HIPA) isolated from aqueous extract of Decalepis hamiltonii roots was examined using transgenic Drosophila model of taupathy expressing wild-type and mutant forms of 2N4R isoform of human microtubule associated protein tau (MAPT)...
September 9, 2016: Neurochemistry International
https://www.readbyqxmd.com/read/27593450/octopamine-cyclic-release-and-its-modulation-of-visual-sensitivity-in-crayfish
#15
Leonardo Rodríguez-Sosa, Gabina Calderón-Rosete, Aída Ortega-Cambranis, Francisco F De-Miguel
The biogenic amine octopamine (OA) modulates invertebrate behavior by changing neuronal responses from sensory inputs to motor outputs. However, the OA modulation of visual sensitivity and its possible coupling to diurnal cycles remains unexplored. Here we studied the diurnal variations in the OA levels in the hemolymph of the crayfish Procambarus clarkii, its release from the structures in the eyestalk and its modulation of the retinal light sensitivity. The hemolymph concentration of OA and its amino acid precursor tyrosine was measured by high-resolution liquid chromatography; OA varied along the 24-hcycle...
January 2017: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/27579611/school-start-time-influences-melatonin-and-cortisol-levels-in-children-and-adolescents-a-community-based-study
#16
Alicia Carissimi, Alessandra Castro Martins, Fabiane Dresch, Lilian Corrêa da Silva, Cristian Patrick Zeni, Maria Paz Hidalgo
School start time influences sleep parameters. Differences between circadian sleep parameters on weekends and weekdays have been associated with obesity, sleep, and psychiatric disorders. Moreover, circadian rhythm dysregulation affects the secretion of some hormones, such as melatonin and cortisol. In the current study, we investigate the effect of school start time on cortisol and melatonin levels in a community sample of Brazilian children and adolescents. This was a cross-sectional study of 454 students (mean age, 12...
2016: Chronobiology International
https://www.readbyqxmd.com/read/27523451/therapeutic-potential-of-melatonin-in-oral-medicine-and-periodontology
#17
REVIEW
Shariq Najeeb, Zohaib Khurshid, Sana Zohaib, Muhammad Sohail Zafar
Melatonin (N-acetyl-5-methoxy tryptamine) is a substance secreted by multiple organs in vertebrates. In addition to playing a part in the circadian cycle of the body, melatonin is known to have antioxidant, antiinflammatory, and antioncotic effects on human tissues. Oral cavity is affected by a number of conditions such as periodontitis, mucositis, cancers, and cytotoxicity from various drugs or biomaterials. Research has suggested that melatonin is effective in treating the aforementioned pathologies. Furthermore, melatonin has been observed to enhance osseointegration and bone regeneration...
August 2016: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/27300111/longtime-napping-is-associated-with-cardiovascular-risk-estimation-according-to-framingham-risk-score-in-postmenopausal-women
#18
Feng Li, Kan Sun, Diaozhu Lin, Yiqin Qi, Yan Li, Li Yan, Meng Ren
OBJECTIVE: Menopause can affect the physiological timing system, which could result in circadian rhythm changes and development of napping habits. Whether longtime napping in postmenopausal women is associated with cardiovascular disease is, however, still debated. The present study aims to investigate this association. METHODS: We conducted a population-based study in 4,616 postmenopausal Chinese women. Information on sleep duration was self-reported. The Framingham General Cardiovascular Risk Score was calculated and used to identify participants at high risk of coronary heart disease (CHD)...
September 2016: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/27153104/investigations-of-the-clock-and-bmal1-proteins-binding-to-dna-a-molecular-dynamics-simulation-study
#19
Tuo Xue, Chunnian Song, Qing Wang, Yan Wang, Guangju Chen
The circadian locomotor output cycles kaput (CLOCK), and brain and muscle ARNT-like 1 (BMAL1) proteins are important transcriptional factors of the endogenous circadian clock. The CLOCK and BMAL1 proteins can regulate the transcription-translation activities of the clock-related genes through the DNA binding. The hetero-/homo-dimerization and DNA combination of the CLOCK and BMAL1 proteins play a key role in the positive and negative transcriptional feedback processes. In the present work, we constructed a series of binary and ternary models for the bHLH/bHLH-PAS domains of the CLOCK and BMAL1 proteins, and the DNA molecule, and carried out molecular dynamics simulations, free energy calculations and conformational analysis to explore the interaction properties of the CLOCK and BMAL1 proteins with DNA...
2016: PloS One
https://www.readbyqxmd.com/read/27148095/functional-implications-of-the-clock-3111t-c-single-nucleotide-polymorphism
#20
Angela R Ozburn, Kush Purohit, Puja K Parekh, Gabrielle N Kaplan, Edgardo Falcon, Shibani Mukherjee, Hannah M Cates, Colleen A McClung
Circadian rhythm disruptions are prominently associated with bipolar disorder (BD). Circadian rhythms are regulated by the molecular clock, a family of proteins that function together in a transcriptional-translational feedback loop. The CLOCK protein is a key transcription factor of this feedback loop, and previous studies have found that manipulations of the Clock gene are sufficient to produce manic-like behavior in mice (1). The CLOCK 3111T/C single-nucleotide polymorphism (SNP; rs1801260) is a genetic variation of the human CLOCK gene that is significantly associated with increased frequency of manic episodes in BD patients (2)...
2016: Frontiers in Psychiatry
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