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https://www.readbyqxmd.com/read/29458197/changes-in-motor-function-cognition-and-emotion-related-behavior-after-right-hemispheric-intracerebral-hemorrhage-in-various-brain-regions-of-mouse
#1
Wei Zhu, Yufeng Gao, Jieru Wan, Xi Lan, Xiaoning Han, Shanshan Zhu, Weidong Zang, Xuemei Chen, Wendy Ziai, Daniel F Hanley, Scott J Russo, Ricardo E Jorge, Jian Wang
Intracerebral hemorrhage (ICH) is a detrimental type of stroke. Mouse models of ICH, induced by collagenase or blood infusion, commonly target striatum, but not other brain sites such as ventricular system, cortex, and hippocampus. Few studies have systemically investigated brain damage and neurobehavioral deficits that develop in animal models of ICH in these areas of the right hemisphere. Therefore, we evaluated the brain damage and neurobehavioral dysfunction associated with right hemispheric ICH in ventricle, cortex, hippocampus, and striatum...
February 16, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29458157/clostridium-innocuum-is-a-vancomycin-resistant-pathogen-that-may-cause-antibiotic-associated-diarrhea
#2
Ju-Hsin Chia, Ting-Shu Wu, Tsu-Lan Wu, Chyi-Liang Chen, Chih-Hsien Chuang, Lin-Hui Su, Hong-Jyun Chang, Chia-Chen Lu, An-Jing Kuo, Hsin-Chih Lai, Cheng-Hsun Chiu
OBJECTIVES: Clostridium innocuum can cause extra-intestinal infection in patients with underlying diseases. The role of C. innocuum in antibiotic-associated diarrhea (AAD) remains unknown. METHODS: Clinical information of 103 patients in which C. innocuum was isolated from was reviewed. We carried out cellular and animal experiments to examine the pathogenic potential of C. innocuum in AAD. RESULTS: Eighty-eight percent (91/103) of the 103 patients received antibiotics within 2 weeks of diarrhea onset...
February 16, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29458100/characterization-and-antioxidant-activities-of-polysaccharides-from-thirteen-boletus-mushrooms
#3
Lan Zhang, Yu Hu, Xiaoyu Duan, Tingting Tang, Yingbin Shen, Bin Hu, Aiping Liu, Hong Chen, Cheng Li, Yuntao Liu
Water-soluble polysaccharides were extracted from the caps and stipes of thirteen boletus mushrooms representing five different species collected in Southwest China. Investigations of their structures and antioxidant activities allowed an evaluation of structure-function relationships. The polysaccharides were composed mainly of the monosaccharides arabinose, xylose, mannose, glucose and galactose. Most samples displayed a broad molecular weight range, with significant differences observed between the molecular weight ranges of the polysaccharides from the caps and the stipes...
February 16, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29457811/liquid-crystalline-behaviour-of-self-assembled-laponite%C3%A2-pll-peg-nanocomposites
#4
P Xu, Y Lan, Z Xing, E Eiser
Synthetic LAPONITE®-clay particles with platelet-like shape display strong aging when dispersed in aqueous solutions, preventing the latter from reaching their natural liquid-crystalline equilibrium state. Here we introduce a facile method that successfully prevents this aging behaviour and enables accessing the systems' liquid-crystal and crystalline phases. We graft the comb-like polymer PLL-PEG (poly(l-lysine)-g-poly(ethylene glycol)) onto the clay surfaces from solution, thereby screening the negative surface charges and thus ensuring steric stabilisation...
February 19, 2018: Soft Matter
https://www.readbyqxmd.com/read/29456778/incidence-and-functional-outcomes-of-scapholunate-diastases-associated-distal-radius-fractures-a-2-year-follow-up-scapholunate-dissociation
#5
Jonathan Lans, Alejandro Lasa, Neal C Chen, Jesse B Jupiter
Background: The Scapholunate Interosseous Ligament (SLIL) is the first intrinsic carpal ligament to be injured in wrist trauma, present in up to 64% of the distal radius fractures. However, it remains unclear what patients develop symptoms, making primary treatment of these injuries accompanying distal radius fractures remains questionable. Objective: The aim of this study was to evaluate the functional outcomes of patients with scapholunate diastasis associated with distal radius fractures...
2018: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/29456409/recombinant-expressed-vasoactive-intestinal-peptide-analogue-ameliorates-tnbs-induced-colitis-in-rats
#6
Chun-Lan Xu, Yu Guo, Lei Qiao, Li Ma, Yi-Yi Cheng
AIM: To investigate the modulatory effect of recombinant-expressed vasoactive intestinal peptide (VIP) analogue (rVIPa) on trinitrobenzene sulfonic acid (TNBS)-induced colitis in rats. METHODS: Forty-eight rats were randomized into six groups: normal control group (Control), model control group (TNBS), ethanol treatment group (ETOH), and VIP treatment groups with different dosage (rVIPa1nmol , rVIPa2nmol , rVIPa4nmol ). Diarrhea and bloody stool were observed. Colonic damage was evaluated histologically...
February 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29455733/taxus-chinensis-ameliorates-diabetic-nephropathy-through-down-regulating-tgf-%C3%AE-1-smad-pathway
#7
Hong-Bo Weng, Wen-Ke Han, Yan-Wen Xiong, Zhou-Hui Jin, Zhen Lan, Cheng Liu, Xue-Mei Zhang, Wen Peng
Diabetic nephropathy (DN) is one of the common microvascular complications of diabetes mellitus. Renal fibrosis is closely related to the deterioration of renal function. The present study aimed to investigate protective effect of Taxus chinensis on high-fat diet/streptozotocin-induced DN in rats and explore the underlying mechanism of action. The rat DN model was established via feeding high fat diet for 4 weeks and subsequently injecting streptozotocin (30 mg·kg-1 body weight) intraperitoneally. The rats with blood glucose levels higher than 16...
February 2018: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/29455726/synthesis-and-biological-evaluation-of-novel-tanshinone-iia-derivatives-for-treating-pain
#8
Qi-Nan Li, Zhi-Peng Huang, Qin-Lan Gu, Zhuo-Er Zhi, Yu-Han Yang, Long He, Kai-Li Chen, Jin-Xin Wang
Due to ineffectiveness and side effects of existing analgesics, chronic pain has become one of the most complex and difficult problems in the clinic. Monoacylglycerol lipase (MAGL) is an essential hydrolase in the endocannabinoid system and has been identified as a potential target for the treatment of pain. In the present study, we designed and synthesized twelve tanshinone IIA analogs and screened their activity against MAGL. Selected compounds were tested for analgesic activity in vivo, with the acetic acid writhing test model...
February 2018: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/29455649/molecular-subtyping-of-nasopharyngeal-carcinoma-npc-and-a-microrna-based-prognostic-model-for-distant-metastasis
#9
Lan Zhao, Alvin H W Fong, Na Liu, William C S Cho
BACKGROUND: Nasopharyngeal carcinoma (NPC) is a highly invasive and metastatic cancer, with diverse molecular characteristics and clinical outcomes. This study aims to dissect the molecular heterogeneity of NPC, followed by the construction of a microRNA (miRNA)-based prognostic model for prediction of distant metastasis. METHODS: We retrieved two NPC datasets: GSE32960 and GSE70970 as training and validation cohorts, respectively. Consensus clustering was employed for cluster discovery, and support vector machine was used to build a classifier...
February 19, 2018: Journal of Biomedical Science
https://www.readbyqxmd.com/read/29455509/-treatment-of-sanders-ii-calcaneus-fractures-via-minimally-invasive-sinus-tarsi-approach
#10
Xue-Xun Bao, Chen-Jie Xia, Bi-Yun Zhao, De-Jun Shi, Guan-Hua Lan, Guo-Lin Ren, Zu-Hong Xie, Wen-Xi Du
OBJECTIVE: To study the feasibility and clinical efficacy of a minimally invasive sinus tarsi approach in the treatment of Sanders II calcaneus fractures. METHODS: From August of 2015 to July of 2016, 13 patients(totally 13 feet) with Sanders II intra-articular calcaneus fractures were treated via the minimally invasive sinus tarsi approach. The Böhler angle, Gissane angle and the length, width and height of calcaneus were compared between pre-operation and post-operation...
August 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29455375/severe-mycoplasma-pneumonia-in-child-with-bilateral-parapneumonic-effusion-successfully-treated-with-integrated-chinese-and-western-medicine-a-case-report
#11
Wen-Ying Zeng, Yan Li, Zhi-Lan Xu, Xiao-Lei Xie, Feng-Qin Xu, Na Rui
No abstract text is available yet for this article.
February 17, 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29455198/incidence-survival-and-risk-factors-for-adults-with-acute-myeloid-leukemia-not-otherwise-specified-and-acute-myeloid-leukemia-with-recurrent-genetic-abnormalities-analysis-of-the-surveillance-epidemiology-and-end-results-seer-database-2001-2013
#12
Xiaolu Song, Ye Peng, Xiaogang Wang, Yirui Chen, Lai Jin, Tianxin Yang, Meihua Qian, Wanmao Ni, Xiangmin Tong, Jianping Lan
BACKGROUND/AIM: As the knowledgebase of acute myeloid leukemia (AML) has grown, classification systems have moved to incorporate these new findings. METHODS: We assessed 32,941 patients with AML whose records are contained in the Surveillance, Epidemiology, and End Results (SEER) database. RESULTS: Half of all patients diagnosed between 2001 and 2013 did not have a World Health Organization (WHO) classification. Acute promyelocytic leukemia and acute panmyelosis with myelofibrosis were associated with the longest leukemia-specific survival (110 and 115 months, respectively), and AML with minimal differentiation and acute megakaryoblastic leukemia with the shortest (30 and 28 months, respectively)...
February 16, 2018: Acta Haematologica
https://www.readbyqxmd.com/read/29455183/the-effect-of-lncrna-hotair-on-chemoresistance-of-ovarian-cancer-through-regulation-of-hoxa7
#13
Siwei Liu, Huajiang Lei, Fangyuan Luo, Yilin Li, Lan Xie
This study aimed at investigating the biological functions of long non-coding RNAs (lncRNAs) hox transcript antisense intergenic RNA (HOTAIR) in resistant ovarian cancer cells, exploring the regulation effect of HOTAIR on HOXA7, and investigating their influence on the chemosensitivity of ovarian cancer cells. Quantitative real-time polymerase chain reaction (qRT-PCR) was applied for the verification of HOTAIR expression in resistant and sensitive groups. How HOTAIR downregulation affected cell proliferation, migration and invasion, and apoptosis were determined using the MTT assay and the colony formation assay, the Transwell assay and flow cytometry analysis, respectively...
February 19, 2018: Biological Chemistry
https://www.readbyqxmd.com/read/29454690/hyperimmune-colostrum-alleviates-rheumatoid-arthritis-in-a-collagen-induced-arthritis-murine-model
#14
Lan-Hsin Hung, Chi-Heng Wu, Bi-Fong Lin, Lucy Sun Hwang
Our aging population and the accompanying decline in immune function is a growing concern that may be addressed by finding natural methods to enhance the immunocompetence of our elderly. Bovine milk and colostrum from cows that have been immunized have been shown to provide additional immunoglobulins and other bioactive molecules that enhance immune function. The purpose of this study was to investigate the ability of hyperimmune bovine colostrum to alleviate the symptoms of rheumatoid arthritis in a murine model...
February 14, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29454551/rostral-anterior-cingulate-cortex-is-a-structural-correlate-of-repetitive-tms-treatment-response-in-depression
#15
Aaron D Boes, Brandt D Uitermarkt, Fatimah M Albazron, Martin J Lan, Conor Liston, Alvaro Pascual-Leone, Marc J Dubin, Michael D Fox
BACKGROUND: Repetitive transcranial magnetic stimulation (rTMS) is an effective treatment for medication-refractory major depression, yet the mechanisms of action for this intervention are poorly understood. Here we investigate cerebral cortex thickness as a possible biomarker of rTMS treatment response. METHODS: Longitudinal change in cortical thickness is evaluated relative to clinical outcomes across 48 participants in 2 cohorts undergoing left dorsolateral prefrontal cortex rTMS as a treatment for depression...
January 31, 2018: Brain Stimulation
https://www.readbyqxmd.com/read/29454330/comparison-of-visceral-body-fat-indices-and-anthropometric-measures-in-relation-to-chronic-kidney-disease-among-chinese-adults-from-a-large-scale-cross-sectional-study
#16
Ying Dong, Zengwu Wang, Zuo Chen, Xin Wang, Linfeng Zhang, Jingyu Nie, Congyi Zheng, Jiali Wang, Lan Shao, Ye Tian, Runlin Gao
BACKGROUND: The aim of the study was to assess the association between chronic kidney disease (CKD) and obesity in predicting CKD among Chinese adults, distinguishing between 5 different adiposity indices: visceral fat index (VFI), percentage body fat (PBF), body mass index (BMI), waist circumference (WC) and waist-to-height ratio (WHtR). METHODS: A total of 29,516 participants aged 35 years or above were selected using a stratified multistage random sampling method across China during 2012-2015...
February 17, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29454068/o-glcnacylation-of-rack1-promotes-hepatocellular-carcinogenesis
#17
Fangfang Duan, Hao Wu, Dongwei Jia, Weicheng Wu, Shifang Ren, Lan Wang, Shushu Song, Xinying Guo, Fenglin Liu, Yuanyuan Ruan, Jianxin Gu
BACKGROUND & AIMS: Aberrant oncogenic mRNA translation and protein O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) are general features during tumorigenesis. Nevertheless, whether and how these two pathways are interlinked remain unknown. Our previous study indicated that ribosomal RACK1 promoted the chemoresistance and growth in hepatocellular carcinoma (HCC). The aim of this study is to examine the role of RACK1 O-GlcNAcylation in oncogene translation and HCC carcinogenesis...
February 14, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29453798/melatonin-protects-against-defects-induced-by-deoxynivalenol-during-mouse-oocyte-maturation
#18
Mei Lan, Jun Han, Meng-Hao Pan, Xiang Wan, Zhen-Nan Pan, Shao-Chen Sun
Deoxynivalenol (DON) is one of the most prevalent Fusarium mycotoxins in feedstuff and food. DON causes detrimental effects on human and animal reproductive systems by inducing oxidative stress and apoptosis. While melatonin is a multifunctional endogenous hormone which plays crucial roles in the development of animal germ cells and embryos as a robust deoxidizer. In present study, we explored the effects of melatonin on the DON-exposure mouse oocytes. Our in vitro and in vivo results showed that DON adversely affected mouse oocyte maturation and early embryo cleavage, while melatonin administration ameliorated the toxic effects of DON...
February 17, 2018: Journal of Pineal Research
https://www.readbyqxmd.com/read/29453637/cough-hypersensitivity-in-patients-with-obstructive-sleep-apnea-hypopnea-syndrome
#19
Cuiqin Shi, Siwei Liang, Xianghuai Xu, Qiang Chen, Lan Wang, Li Yu, Hanjing Lv, Zhongmin Qiu
PURPOSE: The purpose of this study was to investigate cough hypersensitivity and its potential mechanisms in patients with obstructive sleep apnea hypopnea syndrome (OSAHS). METHODS: Fifteen OSAHS patients, 12 simple snoring patients, and 15 healthy volunteers received cough sensitivity test and induced sputum cytology. Cough thresholds C2 and C5 (the minimum of capsaicin inducing ≥ 2 and ≥ 5 coughs, respectively), total cell count, cell differentials and the levels of bradykinin, histamine, prostaglandin E 2 , substance P, calcitonin gene-related peptide, pepsin, and interleukin-2 in the induced sputum detected by enzyme-linked immunosorbent assay were compared...
February 16, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29451788/a-systematic-evaluation-of-the-use-of-human-plasma-and-serum-for-mass-spectrometry-based-shotgun-proteomics
#20
Jiayi Lan, Antonio Núñez Galindo, James Doecke, Christopher Fowler, Ralph N Martins, Stephanie R Rainey-Smith, Ornella Cominetti, Loïc Dayon
Over the last two decades, EDTA-plasma has been used as the preferred sample matrix for human blood proteomic profiling. Serum has also been employed widely. Only a few studies have assessed the difference and relevance of the proteome profiles obtained from plasma samples, such as EDTA-plasma or lithium-heparin-plasma, and serum. A more complete evaluation of the use of EDTA-plasma, heparin-plasma, and serum would greatly expand the comprehensiveness of shotgun proteomics of blood samples. In this study, we evaluated the use of heparin-plasma with respect to EDTA-plasma and serum to profile blood proteomes using a scalable automated proteomic pipeline (ASAP2)...
February 16, 2018: Journal of Proteome Research
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