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https://www.readbyqxmd.com/read/28231545/aqueous-extract-of-cortex-dictamni-protects-h9c2-cardiomyocytes-from-hypoxia-reoxygenation-induced-oxidative-stress-and-apoptosis-by-pi3k-akt-signaling-pathway
#1
Lin Li, Yunfeng Zhou, Yanlin Li, Lili Wang, Lan Sun, Lidong Zhou, Hiderori Arai, Yun Qi, Yang Xu
Ischemia-reperfusion injury is the major manifestation of ischemic heart disease, which facilitates cardiac arrhythmias, heart failure and death. Oxidative stress and apoptosis have been involved in the pathogenesis of myocardial ischemia-reperfusion injury. Modern pharmacological studies have indicated that the extracts and active compounds of Cortex Dictamni exhibit antioxidative and cardiovascular protective activities. This study was designed to investigate the protective effect of aqueous extract of Cortex Dictamni (CDAE) on regulating hypoxia/reoxygenation (H/R)-induced cardiomyocytes oxidative stress and apoptosis...
February 20, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28231257/targeted-sequencing-identifies-a-novel-sh2d1a-pathogenic-variant-in-a-chinese-family-carrier-screening-and-prenatal-genetic-testing
#2
Jun-Yu Zhang, Song-Chang Chen, Yi-Yao Chen, Shu-Yuan Li, Lan-Lan Zhang, Ying-Hua Shen, Chun-Xin Chang, Yu-Qian Xiang, He-Feng Huang, Chen-Ming Xu
X-linked lymphoproliferative disease type 1 (XLP1) is a rare primary immunodeficiency characterized by a clinical triad consisting of severe EBV-induced hemophagocytic lymphohistiocytosis, B-cell lymphoma, and dysgammaglobulinemia. Mutations in SH2D1A gene have been revealed as the cause of XLP1. In this study, a pregnant woman with recurrence history of birthing immunodeficiency was screened for pathogenic variant because the proband sample was unavailable. We aimed to clarify the genetic diagnosis and provide prenatal testing for the family...
2017: PloS One
https://www.readbyqxmd.com/read/28230340/all-inkjet-printed-metal-oxide-thin-film-transistor-array-with-good-stability-and-uniformity-using-surface-energy-patterns
#3
Yuzhi Li, Linfeng Lan, Sheng Sun, Zhenguo Lin, Peixiong Gao, Wei Song, Erlong Song, Peng Zhang, Junbiao Peng
An array of inkjet-printed metal-oxide thin-film transistors (TFTs) is demonstrated for the first time with the assistance of surface-energy patterns prepared by printing pure solvent to etch the ultrathin hydrophobic layer. The surface-energy patterns not only restrained the spreading of inks but also provided a facile way to regulate the morphology of metal oxide films without optimizing ink formulation. The fully printed InGaO TFT devices in the array exhibited excellent electron transport characteristics with a maximum mobility of 11...
February 23, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28230038/association-between-hepatitis-b-virus-hepatitis-c-virus-infection-and-primary-hepatocellular-carcinoma-risk-a-meta-analysis-based-on-chinese-population
#4
Libo Li, Xiaolin Lan
OBJECTIVE: To assess the relationship between hepatitis B virus (HBV), hepatitis C virus (HCV), and HBV/HCV double infection and hepatocellular carcinoma risk in Chinese population. MATERIALS AND METHODS: The databases of PubMed and CNKI were electronic searched by reviewers according to the searching words of HBV, HCV, and hepatocellular carcinoma. The related case-control studies or cohort studies were included. The association between virus infection and hepatocellular carcinoma risk was demonstrated by odds ratio (OR) and 95% confidence interval (95% CI)...
December 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28229997/pregnancy-combined-with-epilepsy-and-cerebral-cavernous-malformation
#5
Ya-Lan Xu, Jun-Tao Liu, Yi-Jun Song, Xi-Ya Zhou, Qing-Wei Qi, Xu-Ming Bian, Zhi-Qin Xu, Lei Li
No abstract text is available yet for this article.
2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28229995/sonographic-assessment-of-the-terminal-thoracic-duct-in-patients-with-lymphedema
#6
Chao Gao, Meng Yang, Na Su, Xiong-Wei Li, E-Lan Yang, Jiu-Zuo Huang, Nan-Ze Yu, Xiao Long
No abstract text is available yet for this article.
2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28229994/immunotoxin-therapy-for-lung-cancer
#7
Li-Yi Xie, Hai-Lan Piao, Min Fan, Zhen Zhang, Chen Wang, Darell D Bigner, Xu-Hui Bao
No abstract text is available yet for this article.
2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28229986/executive-function-training-for-children-with-attention-deficit-hyperactivity-disorder
#8
Lan Shuai, David Daley, Yu-Feng Wang, Jin-Song Zhang, Yan-Ting Kong, Xin Tan, Ning Ji
BACKGROUND: Accumulating evidence indicates that attention deficit hyperactivity disorder (ADHD) is associated with core deficits in executive function (EF) which predicts poorer academic and occupational functioning. This makes early intervention targeting EF impairments important to prevent long-term negative outcomes. Cognitive training is a potential ADHD treatment target. The present study aimed to explore the efficacy, feasibility, and acceptability of a cognitive training program (targeting child's multiple EF components and involving parent support in daily life), as a nonpharmacological intervention for children with ADHD...
2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28229600/regioselective-annulation-of-aryl-sulfonamides-with-allenes-through-cobalt-promoted-c-h-functionalization
#9
Tianlong Lan, Liguo Wang, Yu Rao
The development of an efficient method for the construction of biologically relevant sultams is described, which represents the first case of cobalt-promoted C-H/N-H functionalization of sulfonamides with allenes. This newly developed annulation reaction demonstrated good functional group tolerance and excellent regioselectivity. Both terminal monosubstituted allenes and internal disubstituted allenes can be employed to give the desired sultams in good yields. This strategy can be successfully used to build a unique sultam library with novel structural diversity...
February 23, 2017: Organic Letters
https://www.readbyqxmd.com/read/28229488/ultrafast-highly-reversible-and-cycle-stable-lithium-storage-boosted-by-pseudocapacitance-in-sn-based-alloying-anodes
#10
Yinzhu Jiang, Yong Li, Peng Zhou, Zhenyun Lan, Yunhao Lu, Chen Wu, Mi Yan
Boosting power density is one of the primary challenges that current lithium ion batteries face. Alloying anodes that possess suitable potential windows stand at the forefront in pursuing ultrafast and highly reversible lithium storage to achieve high power/energy lithium ion batteries. Herein, ultrafast lithium storage in Sn-based nanocomposite anodes is demonstrated, which is boosted by pseudocapacitance benefitting from a high fraction of highly interconnected interfaces of Fe/Sn/Li2 O. By tailoring the voltage window in the range of 0...
February 23, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28229392/determination-of-rabeprazole-enantiomers-in-commercial-tablets-using-immobilized-cellulose-based-stationary-phase
#11
Miri Kim, Su Kyung Yu, Quoc-Ky Truong, Xuan-Lan Mai, Hyun Kyu Chung, Jong-Seong Kang, Kyeong Ho Kim
Rabeprazole is one of the latest proton-pump inhibitors used for treatment of several gastrointestinal disorders. For therapeutic applications, rabeprazole has been administered as a mixture of R-(+) and S-(-) enantiomers. Owing to pharmacological and toxicological differences between stereoisomers, chiral recognition has now become an integral part of drug research and development. A simple and rapid liquid chromatographic method for enantioselective separation and determination of R-(+) and S-(-) enantiomers of rabeprazole in bulk drug and pharmaceutical formulations was developed...
February 22, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/28229214/diversity-of-lactic-acid-bacteria-associated-with-banana-fruits-in-taiwan
#12
Yi-Sheng Chen, Yu-Jou Liao, Yi-Shan Lan, Hui-Chung Wu, Fujitoshi Yanagida
Banana is a popular fruit worldwide. The lactic acid bacteria (LAB) microflora in banana fruits has not been studied in detail. A total of 164 LAB were isolated from banana fruits in Taiwan. These isolates were initially divided into nine groups (r1 to r9) using restriction fragment length polymorphism analysis and 16S ribosomal DNA sequencing. Isolates belonging to Lactobacillus plantarum group were further divided into three additional groups using multiplex PCR assay targeting the recA gene. The most common bacterial genera found in banana fruits were Lactobacillus and Weissella...
February 22, 2017: Current Microbiology
https://www.readbyqxmd.com/read/28228845/histone-and-dna-methylation-control-by-h3-serine-10-threonine-11-phosphorylation-in-the-mouse-zygote
#13
Jie Lan, Konstantin Lepikhov, Pascal Giehr, Joern Walter
BACKGROUND: In the mammalian zygote, epigenetic reprogramming is a tightly controlled process of coordinated alterations of histone and DNA modifications. The parental genomes of the zygote show distinct patterns of histone H3 variants and distinct patterns of DNA and histone modifications. The molecular mechanisms linking histone variant-specific modifications and DNA methylation reprogramming during the first cell cycle remain to be clarified. RESULTS: Here, we show that the degree and distribution of H3K9me2 and of DNA modifications (5mC/5hmC) are influenced by the phosphorylation status of H3S10 and H3T11...
2017: Epigenetics & Chromatin
https://www.readbyqxmd.com/read/28228635/mir-3202-promoted-h5v-cell-apoptosis-by-directly-targeting-fas-apoptotic-inhibitory-molecule-2-faim2-in-high-glucose-condition
#14
Xiaozhong Huang, Hui Xie, Guanhua Xue, Meng Ye, Lan Zhang
BACKGROUND Vascular complications are a major concern for patients with diabetes. Endothelial cells (ECs) play a key role in vascular function. MicroRNAs (miRNAs) have been shown to play an important role in mediating EC function; miRNAs are vulnerable to hyperglycemic conditions. Previous reports verified that Fas apoptotic inhibitory molecule 2 (FAIM2) can inhibit cell apoptosis through repressing the FAS-associated death domain protein (FADD) pathway. This current study was designed to explore the potential involvement of miR-3202 in the pathogenesis of ECs in high-glucose conditions...
February 23, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28228285/mass-spectrometry-profiling-of-hla-associated-peptidomes-in-mono-allelic-cells-enables-more-accurate-epitope-prediction
#15
Jennifer G Abelin, Derin B Keskin, Siranush Sarkizova, Christina R Hartigan, Wandi Zhang, John Sidney, Jonathan Stevens, William Lane, Guang Lan Zhang, Thomas M Eisenhaure, Karl R Clauser, Nir Hacohen, Michael S Rooney, Steven A Carr, Catherine J Wu
Identification of human leukocyte antigen (HLA)-bound peptides by liquid chromatography-tandem mass spectrometry (LC-MS/MS) is poised to provide a deep understanding of rules underlying antigen presentation. However, a key obstacle is the ambiguity that arises from the co-expression of multiple HLA alleles. Here, we have implemented a scalable mono-allelic strategy for profiling the HLA peptidome. By using cell lines expressing a single HLA allele, optimizing immunopurifications, and developing an application-specific spectral search algorithm, we identified thousands of peptides bound to 16 different HLA class I alleles...
February 21, 2017: Immunity
https://www.readbyqxmd.com/read/28227355/automatic-recognition-of-pertrochanteric-bone-fractures-in-femur-using-level-sets
#16
Ling Wang, Hong Cheng, Hai Lan, Yingjie Zheng, Kainan Li, Ling Wang, Hong Cheng, Hai Lan, Yingjie Zheng, Kainan Li, Ling Wang, Yingjie Zheng, Hong Cheng, Hai Lan, Kainan Li
Femur fracture is one of the common diseases in the elderly. In this paper, an automatic and efficient classification method of femoral pertrochanteric fractures is proposed based on image segmentation techniques. The types of femoral pertrochanteric fracture are defined firstly according to the difference of fracture parts. To reduce the computational complexity, only four directions images are used in each 3D femur, i.e. the anterior, the anterolateral, the posterior and the posterolateral images of a femur...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227018/using-constrained-information-entropy-to-detect-rare-adverse-drug-reactions-from-medical-forums
#17
Yi Zheng, Chaowang Lan, Hui Peng, Jinyan Li, Yi Zheng, Chaowang Lan, Hui Peng, Jinyan Li, Jinyan Li, Hui Peng, Chaowang Lan, Yi Zheng
Adverse drug reactions (ADRs) detection is critical to avoid malpractices yet challenging due to its uncertainty in pre-marketing review and the underreporting in post-marketing surveillance. To conquer this predicament, social media based ADRs detection methods have been proposed recently. However, existing researches are mostly co-occurrence based methods and face several issues, in particularly, leaving out the rare ADRs and unable to distinguish irrelevant ADRs. In this work, we introduce a constrained information entropy (CIE) method to solve these problems...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226857/development-of-a-closed-loop-system-for-tremor-suppression-in-patients-with-parkinson-s-disease
#18
F L Xu, M Z Hao, S Q Xu, Z X Hu, Q Xiao, N Lan, F L Xu, M Z Hao, S Q Xu, Z X Hu, Q Xiao, N Lan, S Q Xu, Z X Hu, Q Xiao, M Z Hao, N Lan, F L Xu
More than 70% of patients suffering Parkinson's disease (PD) exhibit resting tremor in their extremities, hampering their ability to perform daily activities. Based on our earlier studies on corticospinal transmission of tremor signals [10,11], we hypothesize that cutaneous afferents evoked by surface stimulation can produce an inhibitory effect on propriospinal neurons (PN), which in turn will suppress tremor signals passing through the PN. This paper presents the development of a closed-loop system for tremor suppression by transcutaneous electrical nerve stimulation (TENS) of sensory fibers beneath the skin...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226835/analysis-of-muscle-synergy-for-evaluation-of-task-specific-performance-in-stroke-patients
#19
Si Li, Cheng Zhuang, Xiao Zhang, Chuanxin M Niu, Qing Xie, Ning Lan, Si Li, Cheng Zhuang, Xiao Zhang, Chuanxin M Niu, Qing Xie, Ning Lan, Chuanxin M Niu, Xiao Zhang, Cheng Zhuang, Si Li, Ning Lan, Qing Xie
Muscle synergy represents a central neural module that organizes and activates a group of muscles when performing a certain task. However, whether muscle synergy is a good physiological indicator of motor ability in task performance for patients suffering stroke is not clear. The purpose of this study is to understand how information of task-specific muscle synergy in healthy subjects and patients post stroke can be used to evaluate their motor ability, and further to assist motor rehabilitation for stroke patients...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226833/a-new-approach-to-mitigate-the-effect-of-force-variation-on-pattern-recognition-for-myoelectric-control
#20
Xiangxin Li, Rui Xu, Oluwarotimi Williams Samuel, Lan Tian, Haiqing Zou, Xiufeng Zhang, Shixiong Chen, Peng Fang, Guanglin Li, Xiangxin Li, Rui Xu, Oluwarotimi Williams Samuel, Lan Tian, Haiqing Zou, Xiufeng Zhang, Shixiong Chen, Peng Fang, Guanglin Li, Guanglin Li, Shixiong Chen, Peng Fang, Haiqing Zou, Xiangxin Li, Rui Xu, Oluwarotimi Williams Samuel, Lan Tian, Xiufeng Zhang
In myoelectric prosthetic control, the motion classification performance would be decayed if an electromyography (EMG) pattern to be recognized differs significantly from the one used for classifier training. Generally, the training signals are acquired when a subject performs motions with a proper force. In practical use of a myoelectric prosthesis, however, the variation of force levels to do a motion would be inevitable, which will cause a change of EMG patterns. In this study, we proposed a Parallel Classification Strategy consisting of three parallel classifiers created at low, medium, and high force levels, respectively, and designed a regulation to categorize the input signals into corresponding classifiers for pattern recognition...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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