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https://www.readbyqxmd.com/read/28938720/deep-whole-genome-sequencing-of-90-han-chinese-genomes
#1
Tianming Lan, Haoxiang Lin, Wenjuan Zhu, Tellier Christian Asker Melchior Laurent, Mengcheng Yang, Xin Liu, Jun Wang, Jian Wang, Huanming Yang, Xun Xu, Xiaosen Guo
Next-generation sequencing provides a high-resolution insight into human genetic information. However, the focus of previous studies has primarily been on low-coverage data due to the high cost of sequencing. Although the 1000 Genomes Project and the Haplotype Reference Consortium have both provided powerful reference panels for imputation, low-frequency and novel variants remain difficult to discover and call with accuracy on the basis of low-coverage data. Deep sequencing provides an optimal solution for the problem of these low-frequency and novel variants...
September 1, 2017: GigaScience
https://www.readbyqxmd.com/read/28938665/meta-analysis-of-the-association-of-the-cyp2j2-g-50t-polymorphism-with-coronary-artery-disease
#2
Jian Chen, Dong-Fei Wang, Guo-Dong Fu, Jie Ding, Lei-Yang Chen, Jia-Lan Lv, Juan Fang, Xiang Yin, Xiao-Gang Guo
The association of the CYP2J2 G-50T polymorphism with coronary artery disease has been explored, but the results remain controversial. Thus, a meta-analysis was conducted to provide a comprehensive estimate of this association. We selected ten articles encompassing 12 independent case-control studies with 7063 cases and 10,453 controls for this meta-analysis. Overall, we found significant associations between the CYP2J2 G-50T polymorphism and coronary artery disease risk in three genetic models (allele model: odds ratio (OR) = 1...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938642/facile-total-synthesis-of-lysicamine-and-the-anticancer-activities-of-the-ru-ii-rh-iii-mn-ii-and-zn-ii-complexes-of-lysicamine
#3
Jiao-Lan Qin, Ting Meng, Zhen-Feng Chen, Xiao-Li Xie, Qi-Pin Qin, Xiao-Ju He, Ke-Bin Huang, Hong Liang
Lysicamine is a natural oxoaporphine alkaloid, which isolated from traditional Chinese medicine (TCM) herbs and has been shown to possess cytotoxicity to hepatocarcinoma cell lines. Reports on its antitumor activity are scarce because lysicamine occurs in plants at a low content. In this work, we demonstrate a facile concise total synthesis of lysicamine from simple raw materials under mild reaction conditions, and the preparation of the Ru(II), Rh(III), Mn(II) and Zn(II) complexes 1-4 of lysicamine (LY). All the compounds were fully characterized by elemental analysis, IR, ESI-MS, (1)H and (13)C NMR, as well as single-crystal X-ray diffraction analysis...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938520/galangin-suppresses-hepatocellular-carcinoma-cell-proliferation-by-reversing-the-warburg-effect
#4
Yajun Wang, Biyun Lin, Huimin Li, Liubo Lan, Huajun Yu, Shang Wu, Jun Wu, Haitao Zhang
Hepatocellular carcinoma (HCC) is the sixth most common cancer. The Warburg effect is an important way by which HCC adapts to a hypoxic environment. The aim of the present study was to determine whether and how galangin reverses the Warburg effect in HCC cells. We treated three HCC cell lines, HepG2, Hep3B and PLC/PRF/5 with galangin for 24h, respectively. Cell proliferation was measured with MTT assay. Glucose uptake, lactate production and the oxygen consumption were measured. Pyruvate kinase activities were detected by measuring the consumption of NADH, and glycolytic pathway-related proteins were measured by Western blotting...
September 18, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28937629/tracking-of-maneuvering-complex-extended-object-with-coupled-motion-kinematics-and-extension-dynamics-using-range-extent-measurements
#5
Lifan Sun, Baofeng Ji, Jian Lan, Zishu He, Jiexin Pu
The key to successful maneuvering complex extended object tracking (MCEOT) using range extent measurements provided by high resolution sensors lies in accurate and effective modeling of both the extension dynamics and the centroid kinematics. During object maneuvers, the extension dynamics of an object with a complex shape is highly coupled with the centroid kinematics. However, this difficult but important problem is rarely considered and solved explicitly. In view of this, this paper proposes a general approach to modeling a maneuvering complex extended object based on Minkowski sum, so that the coupled turn maneuvers in both the centroid states and extensions can be described accurately...
September 22, 2017: Sensors
https://www.readbyqxmd.com/read/28937158/bioactivity-guided-isolation-of-neuritogenic-triterpenoids-from-the-leaves-of-ilex-latifolia-thunb
#6
Xueli Cao, Yu Liu, Jing Li, Lan Xiang, Hiroyuki Osada, Jianhua Qi
Ilex latifolia Thunb is a traditional Chinese tea and herbal medicine. In this study, one new triterpene saponin (1) and six known triterpenoids (2-7) were isolated from the methanol extract of I. latifolia using a PC12 cell bioassay system. The structures and stereochemistry of these compounds were elucidated using spectroscopic methods and chemical derivatization. This new triterpene saponin (1) was characterized as an ursolic type acid with a 19α-hydroxyl and a trisaccharide moiety at C-3. Compound 1 significantly promoted the neurite outgrowth in PC12 cells by 52% at 10 μM, whereas compounds 2-7 showed less neuritogenic activity...
September 22, 2017: Food & Function
https://www.readbyqxmd.com/read/28937050/preoperative-evaluation-for-complex-female-genital-tract-malformation-using-three-dimensional-printing-technology
#7
Shu Wang, Shan Deng, Lan Zhu, Jing-Jing Lu, Yue Wang, Jing-He Lang
No abstract text is available yet for this article.
October 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28937041/evaluation-of-circulating-endometrial-cells-as-a-biomarker-for-endometriosis
#8
Ying Chen, Hong-Lan Zhu, Zhe-Wen Tang, Kuang Hong Neoh, Dong-Fang Ouyang, Heng Cui, Hong-Yan Cheng, Rui-Qiong Ma, Xue Ye, Ray Ps Han, Xiao-Hong Chang
BACKGROUND: Circulating endometrial cells (CECs) have been reported to be present in the peripheral blood of women with endometriosis (EM), providing clear and specific evidence of the presence of ectopic lesions. In this study, we established a method with a high detection rate of CECs, assessed the diagnostic value of CECs for EM and compared with serum CA125, and proposed a hypothesis for the pathogenesis of EM from the new perspective of CECs. METHODS: The participants were enrolled prospectively from October 2015 to July 2016...
October 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28936983/teaching-practice-and-experiences-of-verifying-the-three-laws-of-genetics-based-on-the-sslp-marker-analysis
#9
Xue-Ying Huang, Kai Fan, Yan-Fang Ye, Bin Wang, Wei-Ren Wu, Tao Lan
We explored the practical effect of the genetic analysis of simple sequence length polymorphism (SSLP) molecular markers in rice in the genetics lab course. Two parents and their F2 population were analyzed and detected with three SSLP molecular markers that located on two chromosomes of the rice genome. The markers' genotype data were used to verify the three laws of genetics, including segregation, independent assortment and linkage and crossing-over. Our practice has proved not only beneficial to deepen students' understandings about the three laws of genetics, but also conducive to cultivate students' interests in research and innovation and improve their skills and comprehensive analysis abilities...
September 20, 2017: Yi Chuan, Hereditas
https://www.readbyqxmd.com/read/28936922/intraluminal-spindle-shaped-head-suture-induced-occlusion-of-middle-cerebral-artery-in-the-rats
#10
Ye Wu, Lan Hu, Xiaosheng Yang, Xuhui Wang, Liang Wan, Xuming Hua, Juan Cheng, Yi Li
OBJECTIVE: This study aimed to introduce a modified animal model of middle cerebral arterial occlusion (MCAO) through placement of intraluminal spindle-shaped head suture by comparing the traditional MCAO model. METHODS: A total of 60 male Spraque-Dawley (SD) rats were divided into two groups and MCAO was induced using spindle-shaped head suture or round head suture. The mortality, infarct volume, neurological function, success rate of the surgery, and stability of modeling were examined to evaluate the effectiveness of this model...
September 22, 2017: Neurological Research
https://www.readbyqxmd.com/read/28936849/-effect-of-flavonoids-from-abelmoschus-manihot-on-proliferation-differentiation-of-3t3-l1-preadipocyte-and-insulin-resistance
#11
Hong-Die Cai, Shu-Lan Su, Sheng Guo, Yue Zhu, Da-Wei Qian, Wei-Wei Tao, Jin-Ao Duan
Abelmoschus manihot was rich in flavonoids, which has been reported the activity on protecting angiocarpy and improving renal function. This study aimed to explore the action mechanism of five flavonoids from A. manihot on how to ameliorating insulin resistance through the regulation of the glucose and expression of PPARγ, C/EBPα, SREBP-1, resistin, visfatin, adiponectin in 3T3-L1 adipocytes. After the 3T3-L1 preadipocytes were differentiated into mature adipocytes, insulin resistance model was built. Insulin resistance adipocytes were treated with 5, 100 μmol•L⁻¹ quercetin, isoquercitrin, hyperoside, quercitrin-3'-O-glucoside, gossypetin-8-O-β-glucoside...
December 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28936838/-isolation-and-identification-of-rhizobacteria-rs-3-from-panax-ginseng-and-evaluation-of-its-antagonistic-activity
#12
Tie-Lin Wang, Dong-Yue Zhao, Mei-Lan Chen, Zhong-Hua Ma, Lan-Ping Guo
A rhizobacteria strain named RS-3 exhibited inhibitory activity against all five Panax ginseng pathogens was isolated from the root of P. ginseng. This strain was identified as Bacillus amyloliquefaciens based on its morphological character and 16S rDNA sequence. Antagonistic activity experiments indicated that the strain could strongly suppress Botrytis cinerea Pers with an inhibitory rate of 54.4%, suggesting the potentialities of biocontrol agent against diseases that frequently happen on ginseng.
December 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28935949/tunable-polarization-conversion-and-rotation-based-on-a-reconfigurable-metasurface
#13
M Zhang, W Zhang, A Q Liu, F C Li, C F Lan
Polarization is an important property of electromagnetic (EM) wave and different polarization manipulations are required for varied optical applications. Here we report a reconfigurable metasurface which achieves both the polarization conversion and the polarization rotation in THz regime. The metasurface is reconfigured through the micro-electro-mechanical-systems (MEMS) actuation. The cross polarization transmittance from a linear polarized incidence is experimentally tuned from 0 to 28% at 2.66 THz. In addition, the polarization rotation angle is effectively changed from -12...
September 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28935928/location-of-cerebral-microbleeds-and-their-association-with-carotid-intima-media-thickness-a-community-based-study
#14
Chih-Ping Chung, Kun-Hsien Chou, Wei-Ta Chen, Li-Kuo Liu, Wei-Ju Lee, An-Chun Huang, Liang-Kung Chen, Ching-Po Lin, Pei-Ning Wang
To assess whether high cerebral microbleeds (CMBs) are associated with carotid intima-media thickness (CIMT), a marker of systemic atherosclerosis, we cross-sectionally evaluated participants from a community-based study, the I-Lan Longitudinal Aging Study. The participants' demographics and cardiovascular risk factors were determined by questionnaire and/or laboratory measurements. CIMT was measured by ultrasonography. CMBs were assessed by susceptibility-weighted-imaging on 3 T MRI. Of the 962 subjects [62...
September 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28935645/philadelphia-chromosome-positive-b-lymphoblastic-lymphoma-involving-the-genitourinary-system-and-bone-at-initial-diagnosis-and-relapse
#15
Lan Zheng, Shimin Hu
No abstract text is available yet for this article.
September 21, 2017: Blood
https://www.readbyqxmd.com/read/28935482/incidence-rate-of-breakthrough-varicella-observed-in-healthy-children-after-1-or-2-doses-of-varicella-vaccine-results-from-a-meta-analysis
#16
Sui Zhu, Fangfang Zeng, Lan Xia, Hong He, Juying Zhang
BACKGROUND: Although extensive varicella vaccination coverage has been reported in many countries, breakthrough varicella (BV) still occurs in healthy children. We performed a meta-analysis to understand whether 2 varicella vaccine doses are needed in children and, if so, to determine the best time to vaccinate. METHODS: The BV incidence rates after 1 or 2 doses of varicella vaccine were pooled using random effects, and 95% confidence intervals (CI) were used to estimate the risk factors after vaccination...
September 18, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28935242/supplementation-of-cilostazol-during-in-vitro-maturation-enhances-the-meiosis-and-developmental-competence-of-yak-oocytes-by-influencing-camp-content-and-mrna-expression
#17
Xian-Rong Xiong, Dao-Liang Lan, Jian Li, Ya-Qiu Lin, Ming-Yang Li
The efficiency of in vitro embryo production remains low compared with that observed in vivo. Recent studies have independently shown that cyclic adenosine monophosphate (cAMP) modulation prior to in vitro maturation (IVM) supplementation improves oocyte developmental competence. In this context, special cAMP modulators have been applied during IVM as promising alternatives to improve this biotechnology. Accordingly, this study was conducted to evaluate the effects of treatment with cilostazol, a PDE3 inhibitor, during pre-IVM culture on oocyte meiotic maturation in yak...
August 24, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28935014/-impact-of-lung-cancer-deaths-on-life-expectancy-and-years-of-potential-life-lost-from-1981-to-2015-in-kunshan-jiangsu-province-china
#18
Wenbin Hu, Ting Zhang, Wei Qin, Jianguo Shi, Lan Tong, Hequan Qiu, Jie Zhou, Yixu Jin, Xiaoming Luo, Yueping Shen
BACKGROUND: Previous reports have shown that lung cancer incidence and mortality were increasing both in male and female; however, the temporal trends in lung cancer eliminated life expectancy and potential years of life lost (PYLL) are very rare. Thus, we examine the temporal trends in lung cancer eliminated life expectancy and PYLL in Kunshan city, Jiangsu province, 1981-2015. METHODS: Data were collected from vital registry of Kunshan city. Lung cancer eliminated life expectancy and the PYLL were calculated by sex...
September 20, 2017: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/28934296/lactobacillus-paracasei-gmnl-32-exerts-a-therapeutic-effect-on-cardiac-abnormalities-in-nzb-w-f1-mice
#19
Wei-Syun Hu, Peramaiyan Rajendran, Bor-Show Tzang, Yu-Lan Yeh, Chia-Yao Shen, Ray-Jade Chen, Tsung-Jung Ho, Viswanadha Vijaya Padma, Yi-Hsing Chen, Chih-Yang Huang
Systemic lupus erythematosus (SLE) is a disease that mostly affects women. Accelerated atherosclerosis is a high-risk factor associated with SLE patients. SLE associated with cardiovascular disease is one of the most important causes of death. In this study, we demonstrated that Lactobacillus paracasei GMNL-32 (GMNL-32), a probiotic species, exhibits anti-fibrosis and anti-apoptotic effects on the cardiac tissue of NZB/WF1 mice. Female NZB/W F1 mice, a well-known and commonly used lupus-prone mouse strain, were treated with or without GMNL-32 administration for 12 weeks...
2017: PloS One
https://www.readbyqxmd.com/read/28934147/effects-of-precipitant-and-ph-on-coprecipitation-of-nanosized-co-cr-v-alloy-powders
#20
Xiaoyu Chen, Yongxia Li, Lan Huang, Dan Zou, Enxi Wu, Yanjun Liu, Yuanyan Xie, Rui Yao, Songyi Liao, Guangrong Wang, Feng Zheng
Nanosized Co-Cr-V alloy powders were synthesized via coprecipitation method. Effects of precipitants ((NH₄)₂C₂O₄·H₂O and Na₂CO₃) and pH were investigated by X-ray diffraction (XRD), Zeta potential analyzer, thermogravimetry-differential scanning calorimetry (TG-DSC), inductively coupled plasma-atomic emission spectrometry (ICP-AES) and scanning electron microscopy (SEM). Co-Cr-V alloy powders were consisted of major face-centered cubic Co (fcc Co) and minor hexagonal close-packed Co (hcp Co)...
September 21, 2017: Materials
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