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https://www.readbyqxmd.com/read/29917182/molecular-mechanism-of-wnt-signal-pathway-in-multiple-myeloma-cell-line-h929-cell-autophagy
#1
Y-S Liu, X-B Liu, Y-Y Qiu, T Lan, Y Chen
OBJECTIVE: Pathogenic mechanism of multiple myeloma is still unclear yet. Abnormality in cell autophagy is closely correlated with various orthopedic diseases especially multiple myeloma. Therefore, this study investigated the mechanism of cell autophagy abnormality in multiple myeloma occurrence and clinical implications. MATERIALS AND METHODS: Using multiple myeloma cell line H929 as the model, cells were treated with UV irradiation. Western blot was used to measure the autophagy of H929 cell, expression level of autophagy molecules and activation of autophagy signal pathway such as Wnt...
June 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29916548/methylation-profiles-of-mir34-gene-family-in-vietnamese-patients-suffering-from-breast-and-lung-cancers
#2
Vo Thi Thuong Lan, Ho Van Son, Vu Lan Trang, Nguyen Thu Trang, Nguyen Thi Phuong, Nguyen Linh Toan, Pham Anh Thuy Duong
The three genes encoding small non‑coding microRNA (miR)34a, MIR34b and MIR34c act as tumor‑suppressor genes. Their aberrant expressions regulated by DNA methylation have been frequently found in various types of cancer. In the present study, the DNA promoter methylation profiles of the MIR34 gene family were analyzed using the methylation specific polymerase chain reaction in order to clarify their association with breast and lung cancer, non‑cancerous or normal adjacent tissues. The methylation frequency of MIR34a was significantly higher in breast cancer (49...
June 18, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29916506/tailoring-the-structure-ph-sensitivity-and-catalytic-performance-in-suzuki-miyaura-cross-couplings-of-ln-pd-mofs-based-on-the-1-1-di-p-carboxybenzyl-2-2-diimidazole-linker
#3
Li-Xin You, Lan-Xin Cui, Bai-Bei Zhao, Gang Xiong, Fu Ding, Bao-Yi Ren, Zhong-Liang Shi, Ileana Dragutan, Valerian Dragutan, Ya-Guang Sun
An array of heterobimetallic Pd/Ln MOFs (1-4) with Sm, Eu, Tb, Dy as preferred metal nodes and 1,1'-di(p-carboxybenzyl)-2,2'-diimidazole (H2L) as a fairly suitable bifunctional organic linker have been synthesized, fully characterized and tested as catalysts in cross-coupling reactions. These robust MOFs, ensuring a uniform distribution of Pd, showed excellent stability in air and high catalytic activity in Suzuki-Miyaura reactions conducted in neat water, neat ethanol as well as water-ethanol mixture. Depending on the solvent, complex 1 could be effectively recycled 4-8 times without significant loss of catalytic activity...
June 19, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29916259/polymorphisms-c677t-and-a1298c-of-mthfr-gene-homocysteine-levels-and-prothrombotic-biomarkers-in-coronary-and-pulmonary-thromboembolic-disease
#4
Eulo Lupi-Herrera, María Elena Soto-López, Antonio de Jesús Lugo-Dimas, Marcela Elizabeth Núñez-Martínez, Ricardo Gamboa, Claudia Huesca-Gómez, Lilia Mercedes Sierra-Galán, Verónica Guarner-Lans
The activity of the enzyme methylenetetrahydrofolate reductase (MTHFR) determines homocysteine (Hcy) levels, and polymorphisms in its gene affect the activity of the enzyme. Changes in the enzyme's activity may lead to a higher susceptibility to develop arterial and venous thromboembolic disease. The aim was to analyze the relationship between the C677T and A1298C polymorphisms of MTHFR, Hcy levels, and prothrombotic biomarkers in pulmonary embolism (PE) and acute myocardial ischemia (AMI). Clinical files of patients with thromboembolic diseases having complete data and whose doctor had requested an assay to determine the polymorphisms of the MTHFR gene, Hcy levels, and prothrombotic biomarkers were studied to search for the correlation between mutations of the MTHFR gene and Hcy levels in the different diseases...
January 1, 2018: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/29916239/isolation-and-characterization-of-angiotensin-i-converting-enzyme-ace-inhibitory-peptides-from-the-enzymatic-hydrolysate-of-carapax-trionycis-the-shell-of-the-turtle-pelodiscus-sinensis
#5
Pengying Liao, Xiongdiao Lan, Dankui Liao, LiXia Sun, Liqin Zhou, Jianhua Sun, Zhangfa Tong
Carapax Trionycis (the shell of the turtle Pelodiscus sinensis) was hydrolyzed by six different commercial proteases. The hydrolysate prepared from papain showed stronger inhibitory activity against angiotensin I-converting enzyme (ACE) than other extracts. Two noncompetitive ACE inhibitory peptides were purified successively by ultrafiltration, gel filtration chromatography, ion exchange column chromatography, and high-performance liquid chromatography (HPLC). The amino acid sequences of them were identified as KRER and LHMFK, with IC50 values of 324...
June 19, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29915826/glass-formation-of-a-dmso-water-mixture-probed-with-a-photosynthetic-pigment
#6
Adriana Huerta-Viga, Linh-Lan Nguyen, Saeed Amirjalayer, Jamie H N Sim, Zhengyang Zhang, Howe-Siang Tan
Despite their extensive industrial usage, glass-forming liquids are not fully understood, and methods to investigate their dynamical heterogeneity are sought after. Here we show how the appearance of a second component in the visible absorption spectrum of a photosynthetic pigment upon cooling can be used to probe the glass transition of a dimethylsulfoxide-water mixture. The changes in the relative ratio of the two components with respect to temperature follow a sigmoid curve, and we show that the second component arises due to protonation of the pigment at low temperatures...
June 19, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29915382/targeted-exome-analysis-identifies-the-genetic-basis-of-disease-in-over-50-of-patients-with-a-wide-range-of-ataxia-related-phenotypes
#7
Miao Sun, Amy Knight Johnson, Viswateja Nelakuditi, Lucia Guidugli, David Fischer, Kelly Arndt, Lan Ma, Erin Sandford, Vikram Shakkottai, Kym Boycott, Jodi Warman Chardon, Zejuan Li, Daniela Del Gaudio, Margit Burmeister, Christopher M Gomez, Darrel J Waggoner, Soma Das
PURPOSE: To examine the impact of a targeted exome approach for the molecular diagnosis of patients nationwide with a wide range of ataxia-related phenotypes. METHODS: One hundred and seventy patients with ataxia of unknown etiology referred from clinics throughout the United States and Canada were studied using a targeted exome approach. Patients ranged in age from 2 to 88 years. Analysis was focused on 441 curated genes associated with ataxia and ataxia-like conditions...
June 18, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29915368/selection-and-validation-of-reference-genes-for-mrna-expression-by-quantitative-real-time-pcr-analysis-in-neolamarckia-cadamba
#8
Tian Huang, Jianmei Long, Si-Wen Liu, Zi-Wei Yang, Qi-Jin Zhu, Xiao-Lan Zhao, Changcao Peng
Neolamarckia cadamba is an economically-important fast-growing tree species in South China and Southeast Asia. As a prerequisite first step for future gene expression studies, we have identified and characterized a series of stable reference genes that can be used as controls for quantitative real time PCR (qRT-PCR) expression analysis in this study. The expression stability of 15 candidate reference genes in various tissues and mature leaves under different conditions was evaluated using four different algorithms, i...
June 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29915022/enhanced-cancer-immunotherapy-with-smad3-slilencing-nk-92-cells
#9
Qing Ming Wang, Patrick Ming-Kuen Tang, Guang-Yu Lian, Chunjie Li, Jinghong Li, Xiao-Ru Huang, Ka-Fai To, Hui-Yao Lan
Natural killer (NK) cells, early effectors in anti-cancer immunity, are paralyzed by TGF-β1, an immunosuppressive cytokine produced by cancer cells. Development and activity of NK cells are largely inhibited in the Smad3-dependent tumor microenvironment. Here, we used genetic engineering to generate a stable SMAD3-silencing human NK cell line NK-92-S3KD, whose cancer-killing activity and cytokine production were significantly enhanced under TGF-β1-rich condition compared to the parental cell line. Interestingly, we identified that IFNG gene is a direct E4BP4 target gene...
June 18, 2018: Cancer Immunology Research
https://www.readbyqxmd.com/read/29914973/circulating-tumor-dna-detectable-in-early-and-late-stage-colorectal-cancer-patients
#10
Ying-Chi Yang, Dong Wang, Lan Jin, Hong-Wei Yao, Jing-Hui Zhang, Jin Wang, Xiao-Mu Zhao, Chun-Ying Shen, Wei Chen, Xue-Liang Wang, Rong Shi, Si-Yi Chen, Zhong-Tao Zhang
Characterization, diagnosis, and treatment of colorectal cancers (CRC) are difficult due to limited biopsy information, impracticality of repeated biopsies, and cancer biomarker fallibility. Circulating tumor DNA (ctDNA) has recently been investigated as a non-invasive way to gain representative gene mutations in tumors, in addition to monitoring disease progression and response to treatment. We analyzed ctDNA mutations and concentrations in 47 early- and late-stage CRC patients using a targeted sequencing approach using a panel that covers 50 cancer-related genes...
June 18, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29914609/identification-of-chronic-obstructive-pulmonary-disease-subgroups-in-13-asian-cities
#11
W J Kim, V Gupta, M Nishimura, H Makita, L Idolor, C Roa, L-C Loh, C-K Ong, J-S Wang, W Boonsawat, K D Gunasekera, D Madegedara, H-P Kuo, C-H Wang, C Wang, T Yang, Y-X Lin, F W S Ko, D S C Hui, L T T Lan, Q T T Vu, A B Bhome, A Ng, J B Seo, B Y Lee, J S Lee, Y-M Oh, S-D Lee
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a heterogeneous condition that can differ in its clinical manifestation, structural changes and response to treatment. OBJECTIVE: To identify subgroups of COPD with distinct phenotypes, evaluate the distribution of phenotypes in four related regions and calculate the 1-year change in lung function and quality of life according to subgroup. METHODS: Using clinical characteristics, we performed factor analysis and hierarchical cluster analysis in a cohort of 1676 COPD patients from 13 Asian cities...
July 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29914558/risk-factors-for-avian-influenza-virus-in-backyard-poultry-flocks-and-environments-in-zhejiang-province-china-a-cross-sectional-study
#12
Xiao-Xiao Wang, Wei Cheng, Zhao Yu, She-Lan Liu, Hai-Yan Mao, En-Fu Chen
BACKGROUND: Human infection of avian influenza virus (AIV) remains a great concern. Although live poultry markets are believed to be associated with human infections, ever more infections have been reported in rural areas with backyard poultry, especially in the fifth epidemic of H7N9. However, limited information is available on backyard poultry infection and surrounding environmental contamination. METHODS: Two surveillance systems and a field survey were used to collect data and samples in Zhejiang Province...
June 19, 2018: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/29914501/3d-printing-individualized-heel-cup-for-improving-the-self-reported-pain-of-plantar-fasciitis
#13
Lan Li, Longfei Yang, Fei Yu, Jianping Shi, Liya Zhu, Xianfeng Yang, Huajian Teng, Xingsong Wang, Qing Jiang
BACKGROUND: To explore the therapeutic effect and the biomechanical mechanism of 3D printing individualized heel cup in treating of plantar heel pain. METHODS: The clinical effect was evaluated by plantar pressure analysis and pain assessment in participants. Its biomechanical mechanism of protecting the plantar heel was explored using finite element simulation. RESULTS: The individualized heel cup could support and protect the osseous structure and soft tissue of plantar heel while walking and jogging, as well as significantly reduce the self-reported pain after being worn for 4 weeks...
June 18, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29914356/subcellular-stoichiogenomics-reveal-cell-evolution-and-electrostatic-interaction-mechanisms-in-cytoskeleton
#14
Yu-Juan Zhang, Chengxu Zhu, Yiran Ding, Zheng-Wen Yan, Gong-Hua Li, Yang Lan, Jian-Fan Wen, Bin Chen
BACKGROUND: Eukaryotic cells contain a huge variety of internally specialized subcellular compartments. Stoichiogenomics aims to reveal patterns of elements usage in biological macromolecules. However, the stoichiogenomic characteristics and how they adapt to various subcellular microenvironments are still unknown. RESULTS: Here we first updated the definition of stoichiogenomics. Then we applied it to subcellular research, and detected distinctive nitrogen content of nuclear and hydrogen, sulfur content of extracellular proteomes...
June 18, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29914024/impact-of-mild-cognitive-impairment-on-mortality-and-cause-of-death-in-the-elderly
#15
Jong Bin Bae, Ji Won Han, Kyung Phil Kwak, Bong Jo Kim, Shin Gyeom Kim, Jeong Lan Kim, Tae Hui Kim, Seung-Ho Ryu, Seok Woo Moon, Joon Hyuk Park, Jong Chul Youn, Dong Young Lee, Dong Woo Lee, Seok Bum Lee, Jung Jae Lee, Jin Hyeong Jhoo, Ki Woong Kim
BACKGROUND: Mild cognitive impairment (MCI) is a cognitive state that lies on the continuum between normal aging and dementia, and the prevalence of MCI is higher than dementia. However, the risk for mortality of people with MCI has been far less studied than that of people with dementia, and the population attributable risk percent (PAR%) of death attributable to MCI has not been estimated yet. OBJECTIVE: To investigate the impact of MCI on mortality and the cause of death in the elderly, and to estimate the PAR% of deaths attributable to MCI...
June 8, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29912898/taxonomic-and-phylogenetic-diversity-of-vascular-plants-at-ma-anling-volcano-urban-park-in-tropical-haikou-china-reponses-to-soil-properties
#16
Xia-Lan Cheng, Lang-Xing Yuan, Mir Mohammad Nizamani, Zhi-Xin Zhu, Cynthia Ross Friedman, Hua-Feng Wang
Anthropogenic processes and socio-economic factors play important roles in shaping plant diversity in urban parks. To investigate how plant diversity of Ma' anling urban volcano park in Hainan Province, China respond to these factors, we carried out a field investigation on the taxonomic and phylogenetic diversity of vascular plants and soil properties in this area. We found 284 species of vascular plants belonging to 88 families and 241 genera, which included 194 native species, 23 invasive species, 31 naturalized species, 40 cultivars, and 4 rare / endangered plant species...
2018: PloS One
https://www.readbyqxmd.com/read/29912724/selection-of-patients-recumbent-position-laterality-according-to-physician-handedness-bias-increases-the-success-rate-of-lumbar-puncture-a-multicenter-study
#17
Jian-Lan Zhao, Yi-Rui Sun, Qiao Shan, Zhi-Peng Xiao, Ben-Chao Hou, Jin Hu
BACKGROUND: Lumbar puncture (LP) is a medical procedure required during spinal anesthesia and for obtaining cerebrospinal fluid samples in the diagnosis of neurological disorders. The aim of this study was to assess the effects of physicians' handedness bias and the laterality of patients' recumbent position on the success rate of LPs. METHODS AND PATIENTS: A prospective multicenter study including 36 physicians (18 left-handed and 18 right-handed) and 7200 patients was conducted in 6 medical centers...
June 15, 2018: Journal of Neurosurgical Anesthesiology
https://www.readbyqxmd.com/read/29911958/trajectories-of-depression-in-adolescents-and-young-adults-in-vietnam-during-rapid-urbanisation-evidence-from-a-longitudinal-study
#18
Quyen Tt Bui, Lan Th Vu, Dien M Tran
OBJECTIVES: This paper investigates the trajectories of depression symptoms in adolescents and young adults, and explores factors associated with their depression. METHOD: For each respondent, three waves of data were collected in 2006, 2009 and 2013 from adolescents and young adults aged 10 to 24 years. The modified Center for Epidemiological Studies Depression Scale was used to interview participants, while the generalised estimating equation (GEE) model was used to identify whether certain factors were associated with depression...
May 2018: Journal of Child and Adolescent Mental Health
https://www.readbyqxmd.com/read/29911506/a-systematic-review-of-dating-violence-risk-factors-among-undergraduate-college-students
#19
Alicia Duval, Beth A Lanning, Megan S Patterson
College students are a vulnerable population for dating violence (DV) because of the social environment in which they live and interact with other students. Campus climate surveys are considered best practice for gathering information about the severity and cause of college DV; however, there are still unanswered questions as to why DV remains an alarming public health concern among college students. The aim of this systematic literature review was to examine DV risk factors specific to college students with a special focus on methodological factors and gaps in the literature...
January 1, 2018: Trauma, Violence & Abuse
https://www.readbyqxmd.com/read/29910940/ruthenium-catalyzed-umpolung-carboxylation-of-hydrazones-with-co-2
#20
Si-Shun Yan, Lei Zhu, Jian-Heng Ye, Zhen Zhang, He Huang, Huiying Zeng, Chao-Jun Li, Yu Lan, Da-Gang Yu
The first ruthenium-catalyzed umpolung carboxylation of hydrazones with CO2 to generate important aryl acetic acids is reported. Besides aldehyde hydrazones, a variety of ketone hydrazones, which have not been successfully applied in previous umpolung reactions with other reactive electrophiles, also show high reactivity and selectivity under mild conditions. Moreover, this operationally simple protocol features good functional group tolerance, is readily scalable, and offers easy derivation of important structures, including bioactive felbinac and adiphenine...
June 7, 2018: Chemical Science
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