Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#1
JOURNAL ARTICLE
Ei Mon Khaing, Setthapong Senarat, Kritamorn Jitrangsri, Thawatchai Phaechamud
Oral candidiasis is a fungal infection affecting the oral mucous membrane, and this research specifically addresses on a localized treatment through fluconazole-loaded ibuprofen in situ gel-based oral spray. The low solubility of ibuprofen is advantageous for forming a gel when exposed to an aqueous phase. The 1% w/w fluconazole-loaded in situ gel oral sprays were developed utilizing various concentrations of ibuprofen in N-methyl pyrrolidone. The prepared solutions underwent evaluation for viscosity, surface tension, contact angle, water tolerance, gel formation, interface interaction, drug permeation, and antimicrobial studies...
April 19, 2024: AAPS PharmSciTech
#2
JOURNAL ARTICLE
Ziyao Peng, Jiali Zhang, Meng Zhang, Liping Yin, Ziyang Zhou, Cuiting Lv, Zetian Wang, Jianguo Tang
Invasive candidiasis may be caused by Candida albicans ( C. albicans ) colonization of the intestinal tract. Preventing intestinal damage caused by Candida albicans infection and protecting intestinal barrier function have become a critical issue. Integrated analyses of the microbiome with metabolome revealed a remarkable shift of the gut microbiota and tryptophan metabolites, kynurenic acid (KynA), and indolacrylic acid (IA) in mice infected with C. albicans . The transcriptome sequencing indicated that differentially expressed genes were significantly associated with innate immune responses and inflammatory responses...
April 19, 2024: Food & Function
#3
JOURNAL ARTICLE
Jung Yun Park, Kwan Mo Yang, Jae Young Kwak, Yun Tae Jung
Background: Candida species account for approximately 15% of hospital-associated infections, causing fatal consequences, especially in critically ill patients. This study aimed to evaluate invasive candidiasis (IC) risk factors in critically ill patients undergoing surgery. Patients and Methods: We retrospectively reviewed the medical records of 583 patients who underwent emergency surgery for complicated intra-abdominal infections between January 2016 and December 2021. Patients were divided into two groups according to the presence or absence of IC during their hospital stay...
April 17, 2024: Surgical Infections
#4
REVIEW
Akila Fathallah, Hamed Chouaieb, Moadh Ben Saief, Samar Ismaïl, Moncef Ben Said, David W Denning
With increasing concern about the negative health impact of fungal disease, there is a need to survey what is and is not known about the epidemiology of these infections in Tunisia. We have estimated the incidence and prevalence of the most serious fungal diseases in Tunisia for the first time. Using published literature from Tunisia, or if absent other countries, we have estimated the burden of life-threatening fungal infections and those causing significant morbidity, using deterministic modeling, based on populations at greatest risk...
April 5, 2024: Journal de Mycologie Médicale
#5
JOURNAL ARTICLE
Norida Vélez, Andreys Argel, Ann-Kathrin Kissmann, Daniel Alpízar-Pedraza, Patricia Escandón, Frank Rosenau, Ludger Ständker, Carolina Firacative
INTRODUCTION: Invasive candidiasis is a global public health problem as it poses a significant threat in hospital-settings. The aim of this study was to evaluate C14R, an analog derived from peptide BP100, as a potential antimicrobial peptide against the prevalent opportunistic yeast Candida albicans and the emergent multidrug-resistant yeast Candida auris . METHODS: Antifungal susceptibility testing of C14R against 99 C . albicans and 105 C . auris clinical isolates from Colombia, was determined by broth microdilution...
2024: Frontiers in Cellular and Infection Microbiology
#6
Atousa Hakamifard, Farzin Khorvash, Somayeh Hajiahmadi, Yasaman Eskandari
KEY CLINICAL MESSAGE: Invasive candidiasis may be one of the serious complications of transurethral lithotripsy. Candiduria before this procedure should be assessed, and antifungals should be prescribed. ABSTRACT: This case is about a 44-year-old diabetic female patient who, after trans-urethral lithotripsy with double-J stent insertion, was diagnosed with Candida pneumonia and Candida endophthalmitis.
April 2024: Clinical Case Reports
#7
JOURNAL ARTICLE
Songdi Zhang, Lijuan Zhang, Aikedai Yusufu, Hadiliya Hasimu, Xiaodong Wang, Paride Abliz
OBJECTIVE: This study aims to investigate the clinical distribution characteristics and drug susceptibility profiles of invasive Candida isolates in a tertiary hospital in Urumqi. METHODS: The examination was conducted on samples obtained from patients who were clinically diagnosed with invasive candidiasis in this hospital. A total of 109 strains of Candida strains were identified through the use of internal transcribed spacer (ITS) sequencing and fungal cultivation methods...
2024: Infection and Drug Resistance
#8
JOURNAL ARTICLE
Laura Dotta, Francesca Todaro, Manuela Baronio, Mauro Giacomelli, Marinella Pinelli, Martina Giambarda, Beatrice Brognoli, Silvia Greco, Francesca Rota, Manuela Cortesi, Annarosa Soresina, Daniele Moratto, Cesare Tomasi, Rosalba Monica Ferraro, Silvia Giliani, Raffaele Badolato
INTRODUCTION: The signal transducer and activator of transcription (STAT1) gain-of-function (GOF) syndrome accounts for most cases of chronic mucocutaneous candidiasis but is characterized by a broader clinical phenotype that may include bacterial, viral, or invasive fungal infections, autoimmunity, autoinflammatory manifestations, vascular complications, or malignancies. The severity of lymphopenia may vary and influence the infectious morbidity. METHODS: In our cohort of seven STAT1-GOF patients, we investigated the mechanisms that may determine T lymphopenia, we characterized the interferon gene signature (IGS) and analyzed the effect of ruxolitinib in reverting the immune dysregulation...
April 5, 2024: Journal of Clinical Immunology
#9
REVIEW
Mette Rose Jørgensen
Oral candidiasis (OC), a prevalent opportunistic infection of the oral mucosa, presents a considerable health challenge, particularly in individuals with compromised immune responses, advanced age, and local predisposing conditions. A considerable part of the population carries Candida in the oral cavity, but only few develop OC. Therefore, the pathogenesis of OC may depend on factors other than the attributes of the fungus, such as host factors and other predisposing factors. Mucosal trauma and inflammation compromise epithelial integrity, fostering a conducive environment for fungal invasion...
April 4, 2024: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
#10
REVIEW
Sunita Panda, Mahesh Chandra Sahu, Jyotirmayee Turuk, Sanghamitra Pati
Mucormycosis is the third most frequent invasive mycosis, following candidiasis and aspergillosis. It is frequently neglected due to its rare occurrence; but recently attend the status of notifiable disease due to its higher incidence in both developed and developing nations. India has received global notice since its estimated instances were greater than the global estimated figures. Mucormycosis has several clinical manifestations, including rhino-orbital-cerebral (ROCM), pulmonary, gastrointestinal, cutaneous, renal, and diffuse Mucormycosis...
April 1, 2024: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
#11
JOURNAL ARTICLE
Haizhen Mo, Tao Zhang, Jiayi Zhang, Shurui Peng, Fukun Xiang, Hongbo Li, Yaming Ge, Lishan Yao, Liangbin Hu
Candida albicans is the most leading cause of life-threatening fungal invasive infections, especially for vulvovaginal candidiasis (VVC). Resistance and tolerance to common fungicide has risen great demands on alternative strategies for treating C. albicans infections. In the present study, ferroptosis has been proven to occur in C. albicans by directly exposed to FeSO4 via induing hallmarks of ferroptosis, including Fe2+ overload burden, ROS eruption and lipid peroxidation. Transcriptomic profile gave the great hints of the possible mechanism for fungal ferroptosis that FeSO4 disturb pathways associated to ribosome, tyrosine metabolism, triglyceride metabolism and thiamine metabolism, thus mobilizing death-related gene synthesis...
March 24, 2024: Microbiological Research
#12
BioMed Research International
[This retracts the article DOI: 10.1155/2022/7896218.].
2024: BioMed Research International
#13
JOURNAL ARTICLE
Yiting Zhang, Hu Xing, Grigory Bolotnikov, Markus Krämer, Anil Bozdogan, Ann-Kathrin Kissmann, Tanja Weil, Barbara Spellerberg, Steffen Stenger, Frank Rosenau
Infections caused by yeasts of the genus Candida are likely to occur not only in immunocompromised patients but also in healthy individuals, leading to infections of the gastrointestinal tract, urinary tract, and respiratory tract. Due to the rapid increase in the frequency of reported Candidiasis cases in recent years, diagnostic research has become the subject of many studies, and therefore, we developed a polyclonal aptamer library-based fluorometric assay with high specificity and affinity towards Candida spec...
March 19, 2024: International Journal of Molecular Sciences
#14
JOURNAL ARTICLE
Anshuman Yadav, Sudisht K Sah, David S Perlin, Elena Rustchenko
The opportunistic fungus Candida albicans is the leading cause of invasive candidiasis in immune-compromised individuals. Drugs from the echinocandin (ECN) class, including caspofungin, are used as a first line of therapy against invasive candidiasis. The only known mechanism of clinical resistance to ECNs is point mutations in the FKS1 gene, which encodes the drug target. However, many clinical isolates developed decreased ECN susceptibilities in the absence of resistance-associated FKS1 mutations. We have identified 15 C...
March 19, 2024: Journal of Fungi (Basel, Switzerland)
#15
JOURNAL ARTICLE
Rafał Wiench, Dariusz Paliga, Anna Mertas, Elżbieta Bobela, Anna Kuśka-Kiełbratowska, Sonia Bordin-Aykroyd, Aleksandra Kawczyk-Krupka, Kinga Grzech-Leśniak, Monika Lukomska-Szymanska, Edward Lynch, Dariusz Skaba
BACKGROUND: Candida albicans and similar species are significant pathogens in immunocompromised and hospitalized individuals, known for mucosal colonization and bloodstream/organ invasion. Many pathogenic fungi, including these species, exhibit autofluorescence (R/OF) under specific light conditions, a feature crucial for their detection. AIM: We investigated the use of a 405 nm diode laser for the direct observation of red/orange autofluorescence of Candida spp...
February 26, 2024: Dentistry Journal
#16
JOURNAL ARTICLE
Jeffrey B Locke, Chris M Pillar, Mariana Castanheira, Cecilia G Carvalhaes, David Andes, Jalal A Aram, Christina Andrzejewski, Ken Bartizal, Anita F Das, Taylor Sandison, George R Thompson, Peter G Pappas
Rezafungin is a long-acting, intravenously administered echinocandin for the treatment of candidemia and invasive candidiasis (IC). Non-inferiority of rezafungin vs caspofungin for the treatment of adults with candidemia and/or IC was demonstrated in the Phase 3 ReSTORE study based on the primary endpoints of day 14 global cure and 30-day all-cause mortality. Here, an analysis of ReSTORE data evaluating efficacy outcomes by baseline Candida species is described. Susceptibility testing was performed for Candida species using the Clinical and Laboratory Standards Institute reference broth microdilution method...
March 25, 2024: Antimicrobial Agents and Chemotherapy
#17
JOURNAL ARTICLE
Zhi-Chang Xu, Xiu-Rong Ma, Li-Juan Zhang, Hui-Ting Chen, Ding-Mei Qing, Rong-Tao Li, Rui-Rong Ye, Rui-Rui Wang
With the abuse of antibiotics and azoles, drug-resistant Candida albicans infections have increased sharply and are spreading rapidly, thereby significantly reducing the antifungal efficacy of existing therapeutics. Several patients die of fungal infections every year. Therefore, there is an urgent requirement to develop new drugs. Accordingly, we synthesized a series of polypyridyl ruthenium (II) complexes having the formula [Ru (NN)2 (bpm)] (PF6 )2 (N-N = 2,2'-bipyridine) (bpy, in Ru1), 1,10-phenanthroline (phen, in Ru2), 4,7-diphenyl-1,10-phenanthroline (DIP, in Ru3) (bpm = 2,2'-bipyrimidine) and studied their antifungal activities...
March 12, 2024: Journal of Inorganic Biochemistry
#18
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
March 21, 2024: Nature Reviews. Disease Primers
#19
REVIEW
Cornelia Lass-Flörl, Souha S Kanj, Nelesh P Govender, George R Thompson, Luis Ostrosky-Zeichner, Miriam Alisa Govrins
Invasive candidiasis is an important fungal disease caused by Candida albicans and, increasingly, non-albicans Candida pathogens. Invasive Candida infections originate most frequently from endogenous human reservoirs and are triggered by impaired host defences. Signs and symptoms of invasive candidiasis are non-specific; candidaemia is the most diagnosed manifestation, with disseminated candidiasis affecting single or multiple organs. Diagnosis poses many challenges, and conventional culture techniques are frequently supplemented by non-culture-based assays...
March 21, 2024: Nature Reviews. Disease Primers
#20
JOURNAL ARTICLE
Matteo Bassetti, Daniele R Giacobbe, Christina Agvald-Ohman, Murat Akova, Ana Alastruey-Izquierdo, Sevtap Arikan-Akdagli, Elie Azoulay, Stijn Blot, Oliver A Cornely, Manuel Cuenca-Estrella, Dylan W de Lange, Francesco G De Rosa, Jan J De Waele, George Dimopoulos, Jose Garnacho-Montero, Martin Hoenigl, Souha S Kanj, Philipp Koehler, Bart J Kullberg, Frédéric Lamoth, Cornelia Lass-Flörl, Johan Maertens, Ignacio Martin-Loeches, Patricia Muñoz, Garyphallia Poulakou, Jordi Rello, Maurizio Sanguinetti, Fabio S Taccone, Jean-François Timsit, Antoni Torres, Jose A Vazquez, Joost Wauters, Erika Asperges, Andrea Cortegiani, Cecilia Grecchi, Ilias Karaiskos, Clément Le Bihan, Toine Mercier, Klaus L Mortensen, Maddalena Peghin, Chiara Rebuffi, Sofia Tejada, Antonio Vena, Valentina Zuccaro, Luigia Scudeller, Thierry Calandra
PURPOSE: The aim of this document was to develop standardized research definitions of invasive fungal diseases (IFD) in non-neutropenic, adult patients without classical host factors for IFD, admitted to intensive care units (ICUs). METHODS: After a systematic assessment of the diagnostic performance for IFD in the target population of already existing definitions and laboratory tests, consensus definitions were developed by a panel of experts using the RAND/UCLA appropriateness method...
March 21, 2024: Intensive Care Medicine
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
