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https://www.readbyqxmd.com/read/29762926/genetic-complexity-of-mitral-valve-prolapse-revealed-by-clinical-and-genetic-evaluation-of-a-large-family
#1
Gloria T Haskell, Brian C Jensen, Cecile Skrzynia, Thelsa Pulikkotil, Christian R Tilley, Yurong Lu, Daniel S Marchuk, Leigh Ann Samsa, Kirk C Wilhelmsen, Ethan Lange, Cam Patterson, James P Evans, Jonathan S Berg
BACKGROUND: A genetic component to familial mitral valve prolapse (MVP) has been proposed for decades. Despite this, very few genes have been linked to MVP. Herein is described a four-generation pedigree with numerous individuals affected with severe MVP, some at strikingly young ages. METHODS: A detailed clinical evaluation performed on all affected family members demonstrated a spectrum of MVP morphologies and associated phenotypes. RESULTS: Linkage analysis failed to identify strong candidate loci, but revealed significant regions, which were investigated further using whole-exome sequencing of one of the severely affected family members...
September 2017: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/29753396/prevalence-of-ideal-cardiovascular-health-metrics-in-the-million-veteran-program
#2
Xuan-Mai T Nguyen, Rachel M Quaden, Sarah Wolfrum, Rebecca J Song, Joseph Q Yan, David R Gagnon, Peter W F Wilson, Kelly Cho, Christopher O'Donnell, J Michael Gaziano, Luc Djousse
No data exist on the prevalence of ideal cardiovascular health metrics in a national sample of U.S. veterans. We assessed the prevalence of ideal Life's Simple Seven (LSS) metrics in a cross-sectional study of 554,855 U.S. veterans enrolled in the Million Veteran Program (MVP) from 2011 to 2017. We used the American Heart Association's established criteria to categorize each LSS metric as either poor, intermediate, or ideal for a veteran at time of MVP enrollment. Information on adiposity/body mass index, smoking status, diet, and physical activity was obtained from self-reported survey data, and clinical measurements for total cholesterol, blood pressure, and plasma glucose were obtained from electronic health records...
April 12, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29732567/catheter-ablation-of-papillary-muscle-arrhythmias-implications-of-mitral-valve-prolapse-and-systolic-dysfunction
#3
Adam Lee, Christian Hamilton Craig, Russell Denman, Haris M Haqqani
BACKGROUND: The left ventricular papillary muscles are important components of the mitral valve apparatus. Catheter ablation of ventricular arrhythmias from these sites is challenging. We aim to describe the association between LV papillary muscle ventricular arrhythmias (VAs) and mitral valve prolapse (MVP), and to determine the outcomes of ablation in these patients with a focus on those with MVP and cardiomyopathy. METHODS: 152 patients underwent 170 consecutive procedures for ablation of focal VAs...
May 6, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29689087/identification-of-rna-binding-proteins-in-exosomes-capable-of-interacting-with-different-types-of-rna-rbp-facilitated-transport-of-rnas-into-exosomes
#4
Luisa Statello, Marco Maugeri, Elena Garre, Muhammad Nawaz, Jessica Wahlgren, Alexandros Papadimitriou, Christina Lundqvist, Lennart Lindfors, Anna Collén, Per Sunnerhagen, Marco Ragusa, Michele Purrello, Cinzia Di Pietro, Natalie Tigue, Hadi Valadi
The RNA that is packaged into exosomes is termed as exosomal-shuttle RNA (esRNA); however, the players, which take this subset of RNA (esRNA) into exosomes, remain largely unknown. We hypothesized that RNA binding proteins (RBPs) could serve as key players in this mechanism, by making complexes with RNAs and transporting them into exosomes during the biosynthesis of exosomes. Here, we demonstrate the presence of 30 RBPs in exosomes that were shown to form RNA-RBP complexes with both cellular RNA and exosomal-RNA species...
2018: PloS One
https://www.readbyqxmd.com/read/29644231/mechanistic-insights-of-the-left-ventricle-structure-and-fibrosis-in-the-arrhythmogenic-mitral-valve-prolapse
#5
REVIEW
Leticia Fernández-Friera, Rafael Salguero, Luca Vannini, Ana Fidalgo Argüelles, Fernando Arribas, Jorge Solís
Mitral valve prolapse (MVP) is a common and benign condition. However, some anatomic forms have been recently associated with life-threatening ventricular arrhythmias and sudden cardiac death. Imaging MVP holds the promise of individualized MVP risk assessment. Noninvasive imaging techniques available today are playing an increasingly important role in the diagnosis, prognosis and monitoring of MVP. In this article, we will review the current evidence on arrhythmogenic MVP, with special focus on the utility of echocardiography and CMR for identifying benign and "malignant" forms of MVP...
March 14, 2018: Global Cardiology Science & Practice
https://www.readbyqxmd.com/read/29551289/solution-structures-of-engineered-vault-particles
#6
Ke Ding, Xing Zhang, Jan Mrazek, Valerie A Kickhoefer, Mason Lai, Hwee L Ng, Otto O Yang, Leonard H Rome, Z Hong Zhou
Prior crystal structures of the vault have provided clues of its structural variability but are non-conclusive due to crystal packing. Here, we obtained vaults by engineering at the N terminus of rat major vault protein (MVP) an HIV-1 Gag protein segment and determined their near-atomic resolution (∼4.8 Å) structures in a solution/non-crystalline environment. The barrel-shaped vaults in solution adopt two conformations, 1 and 2, both with D39 symmetry. From the N to C termini, each MVP monomer has three regions: body, shoulder, and cap...
March 7, 2018: Structure
https://www.readbyqxmd.com/read/29544951/grading-of-mitral-regurgitation-in-mitral-valve-prolapse-using-the-average-pixel-intensity-method
#7
Victor Kamoen, Milad El Haddad, Marc De Buyzere, Tine De Backer, Frank Timmermans
AIMS: We recently reported the feasibility of the average pixel intensity (API) method for grading mitral regurgitation (MR) in a heterogeneous MR population. Since mitral valve prolapse (MVP) is an important cause of primary MR, we more specifically investigated the feasibility of the API method and the MR flow dynamics in patients with MVP. METHODS: Transthoracic echocardiography was performed by a single operator in consecutive MVP patients (n=112). MR was assessed using the API method, color Doppler, vena contracta width (VCW), effective regurgitant orifice area (PISA-EROA) and regurgitant volume (PISA-RV)...
May 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29542404/bystander-training-as-leadership-training-notes-on-the-origins-philosophy-and-pedagogy-of-the-mentors-in-violence-prevention-model
#8
Jackson Katz
This article outlines the origins, philosophy, and pedagogy of the Mentors in Violence Prevention (MVP) program, which has played a significant role in the gender violence prevention field since its inception in 1993. MVP was one of the first large-scale programs to target men for prevention efforts, as well as the first to operate systematically in sports culture and the U.S. military. MVP also introduced the "bystander" approach to the field. MVP employs a social justice, gender-focused approach to prevention...
March 1, 2018: Violence Against Women
https://www.readbyqxmd.com/read/29542403/response-to-commentaries-on-bystander-training-as-leadership-training
#9
Jackson Katz
In this article, the author responds to three commentaries about his article "Bystander Training as Leadership Training: Notes on the Origins, Philosophy, and Pedagogy of the Mentors in Violence Prevention Model," published in this volume. Topics covered in the commentaries and response include questions about evaluation and evidence for program effectiveness; the necessity for gender violence prevention education to be gender transformative and part of a comprehensive, multilevel prevention approach, especially for adolescents; and the degree to which Mentors in Violence Prevention (MVP), as a "social justice"-oriented program, incorporates intersectional and anti-oppression frameworks and perspectives...
March 1, 2018: Violence Against Women
https://www.readbyqxmd.com/read/29542393/reflections-on-jackson-katz-and-the-mvp-program
#10
Elizabeth Wilmerding, Mari Knuth-Bouracee, Jeffrey L Edleson
This article offers reflections on the article "Bystander Training as Leadership Training: Notes on the Origins, Philosophy and Pedagogy of the Mentors in Violence Prevention Model" by Jackson Katz in this issue of Violence Against Women. The authors rely on their unique perspectives in varying roles at the University of California (UC) Berkeley, as well as on relevant social science and social justice research. The article explores five themes of violence prevention and anti-oppression work: leadership, social justice, gender identity, issues of identity and status, and diffusion of innovation...
March 1, 2018: Violence Against Women
https://www.readbyqxmd.com/read/29542391/reclaiming-gender-and-power-in-sexual-violence-prevention-in-adolescence
#11
Elizabeth Miller
The Mentors in Violence Prevention (MVP) model seeks to address the root causes of gender violence using a bystander approach and leadership training to challenge structures of patriarchy. Emerging research on adolescent relationship abuse and sexual violence points to key modifiable targets-transforming gender norms, addressing homophobia, integrating with comprehensive sexuality education, and acknowledging the needs of youth already exposed to violence. A social justice-based bystander approach such as the MVP model should be part of a multi-level approach to sexual violence prevention that addresses gender and power, encourages healthy sexuality conversations, and provides safety and support for survivors...
March 1, 2018: Violence Against Women
https://www.readbyqxmd.com/read/29540554/major-vault-protein-a-candidate-gene-in-16p11-2-microdeletion-syndrome-is-required-for-the-homeostatic-regulation-of-visual-cortical-plasticity
#12
Jacque P K Ip, Ikue Nagakura, Jeremy Petravicz, Keji Li, Erik A C Wiemer, Mriganka Sur
Microdeletion of a region in chromosome 16p11.2 increases susceptibility to autism. Although this region contains exons of 29 genes, disrupting only a small segment of the region, which spans 5 genes, is sufficient to cause autistic traits. One candidate gene in this critical segment is MVP , which encodes for the major vault protein (MVP) that has been implicated in regulation of cellular transport mechanisms. MVP expression levels in MVP +/- mice closely phenocopy those of 16p11.2 mutant mice, suggesting that MVP +/- mice may serve as a model of MVP function in 16p11...
March 14, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29534006/research-on-the-factors-influencing-the-measurement-errors-of-the-discrete-rogowski-coil
#13
Mengyuan Xu, Jing Yan, Yingsan Geng, Kun Zhang, Chao Sun
An innovative array of magnetic coils (the discrete Rogowski coil-RC) with the advantages of flexible structure, miniaturization and mass producibility is investigated. First, the mutual inductance between the discrete RC and circular and rectangular conductors are calculated using the magnetic vector potential (MVP) method. The results are found to be consistent with those calculated using the finite element method, but the MVP method is simpler and more practical. Then, the influence of conductor section parameters, inclination, and eccentricity on the accuracy of the discrete RC is calculated to provide a reference...
March 13, 2018: Sensors
https://www.readbyqxmd.com/read/29530068/deregulated-microrna-and-mrna-expression-profiles-in-the-peripheral-blood-of-patients-with-marfan-syndrome
#14
Masood Abu-Halima, Mustafa Kahraman, Dominic Henn, Tanja Rädle-Hurst, Andreas Keller, Hashim Abdul-Khaliq, Eckart Meese
BACKGROUND: MicroRNAs (miRNAs) are small RNAs regulating gene expression post-transcriptionally. While acquired changes of miRNA and mRNA profiles in cancer have been extensively studied, little is known about expression changes of circulating miRNAs and messenger RNAs (mRNA) in monogenic constitutional anomalies affecting several organ systems, like Marfan syndrome (MFS). We performed integrated miRNA and mRNA expression profiling in blood samples of Marfan patients in order to investigate deregulated miRNA and mRNA networks in these patients which could serve as potential diagnostic and prognostic tools for MFS therapy...
March 12, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29525249/prevalence-and-predictive-value-of-microvascular-flow-abnormalities-after-successful-contemporary-percutaneous-coronary-intervention-in-acute-st-segment-elevation-myocardial-infarction
#15
Sourabh Aggarwal, Feng Xie, Robin High, Gregory Pavlides, Thomas R Porter
BACKGROUND: Although microvascular flow abnormalities have been observed following epicardial recanalization in acute ST-segment elevation myocardial infarction (STEMI), the prevalence and severity of these abnormalities in the current era of rapid percutaneous coronary intervention (PCI) has not been evaluated. The objective of this study was to assess microvascular perfusion (MVP) following successful primary PCI in patients with STEMI and how it affects clinical outcome. METHODS: In this single-center, retrospective study, 170 patients who successfully underwent emergent PCI for STEMI were assessed using real-time myocardial contrast echocardiography using a continuous infusion of intravenous commercial microbubbles (3% Definity)...
March 7, 2018: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/29524476/effect-of-dual-chamber-minimal-ventricular-pacing-on-paroxysmal-atrial-fibrillation-incidence-in-myotonic-dystrophy-type-1-patients-a-prospective-randomized-single-blind-crossover-study
#16
Vincenzo Russo, Andrea Antonio Papa, Anna Rago, Carmine Ciardiello, Gerardo Nigro
BACKGROUND: Atrial fibrillation (AF) is a common finding in the myotonic dystrophy type 1 (DM1) population. Pacemakers (PMs) may facilitate the diagnosis and management of frequent subclinical asymptomatic AF episodes. OBJECTIVE: The purpose of this study was to evaluate the effect of minimal ventricular pacing on paroxysmal AF incidence in DM1 patients during a 24-month follow-up period. METHODS: We enrolled 70 DM1 patients (age 43.4 ± 13...
March 8, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29486707/genomic-analysis-in-patients-with-myxomatous-mitral-valve-prolapse-current-state-of-knowledge
#17
S Gasser, H Reichenspurner, E Girdauskas
BACKGROUND: Myxomatous mitral valve prolapse is a common cardiac abnormality. Morbus Barlow is characterized by excess myxomatous leaflet tissue, bileaflet prolapse or billowing, chordae elongation and annular dilatation with or without calcification. Extensive myxoid degeneration with destruction of the normal three-layered leaflet tissue architecture is observed histologically in such patients. Autosomal dominant inheritance with an age and sex-dependent expression has long been recognised...
February 27, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29416210/assesment-of-rhythm-disorders-in-classical-and-nonclassical-mitral-valve-prolapse
#18
Enisa Hodzic
Introduction: Mitral Valve Prolapse (MVP) is the most common cardiac valve pathology of to day. Aim of article was to identify the types and frequency of potentially malignant arrhythmia and atrial brillation in patients with MVP, to determine the differences in these arrhythmias between classical and non-classical MVP, to evaluate the correlation of potentially malignant arrhythmia and atrial fibrillation with MVP with possible clinical complications of arrhythmogenic sudden cardiac death and potential risk of thromboembolic vascular incident...
February 2018: Medical Archives
https://www.readbyqxmd.com/read/29362508/inhibition-of-rm-1-prostate-carcinoma-and-eliciting-robust-immune-responses-in-the-mouse-model-by-using-vegf-m-2-gnrh-3-hinge-mvp-vaccine
#19
Yiqin Wang, Murad Alahdal, Jia Ye, Liangliang Jing, Xiaoxin Liu, Huan Chen, Liang Jin, Rongyue Cao
GnRH and VEGF have been investigated as prostate carcinoma enhancers that support tumor spread and progression. Although both have documented roles in prostate carcinoma and many cancer types, the weak immunogenicity of these peptides has remained a major challenge for use in immunotherapy. Here, we describe a novel strategy to inhibit GnRH and VEGF production and assess the effect on the immune responses against these hormones using the RM-1 prostate cancer model. We designed a novel recombinant fusion protein which combined GnRH and VEGF as a vaccine against this tumor...
January 23, 2018: Genes and Immunity
https://www.readbyqxmd.com/read/29352010/genetics-of-syndromic-and-non-syndromic-mitral-valve-prolapse
#20
REVIEW
Thierry Le Tourneau, Jean Mérot, Antoine Rimbert, Solena Le Scouarnec, Vincent Probst, Hervé Le Marec, Robert A Levine, Jean-Jacques Schott
Mitral valve prolapse (MVP) is a common condition that affects 2%-3% of the general population. MVP is thought to include syndromic forms such as Marfan syndrome and non-syndromic MVP, which is the most frequent form. Myxomatous degeneration and fibroelastic deficiency (FED) are regarded as two different forms of non-syndromic MVP. While FED is still considered a degenerative disease associated with ageing, frequent familial clustering has been demonstrated for myxomatous MVP. Familial and genetic studies led to the recognition of reduced penetrance and large phenotypic variability, and to the identification of prodromal or atypical forms as a part of the complex spectrum of the disease...
January 19, 2018: Heart: Official Journal of the British Cardiac Society
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