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https://www.readbyqxmd.com/read/28506917/atrial-antitachycardia-pacing-and-atrial-remodeling-a-substudy-of-the-international-randomized-minerva-trial
#1
Giuseppe Boriani, Raymond Tukkie, Mauro Biffi, Lluis Mont, Renato Ricci, Helmut Pürerfellner, Giovanni Luca Botto, Antonis S Manolis, Maurizio Landolina, Michele Gulizia, J Harrison Hudnall, Lorenza Mangoni, Andrea Grammatico, Luigi Padeletti
BACKGROUND: Atrial tachycardia (AT) and atrial fibrillation (AF) are common in pacemaker patients and are associated with bad prognosis. OBJECTIVE: To evaluate atrial antitachycardia pacing impact on AT/AF induced atrial remodeling, measured by early recurrence of AT/AF (ERAF) and by change in left atrium diameter (LAD). To evaluate impact of AT/AF duration on ERAF incidence. METHODS: Pacemaker patients were randomized to dual-chamber pacing (Control DDDR-385 patients), managed ventricular pacing (MVP-398 patients) or atrial antitachycardia pacing plus MVP (DDDRP+MVP-383 patients)...
May 12, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28484585/disappearance-of-electrocardiographic-abnormalities-associated-with-the-arrhythmic-pattern-of-a-barlow-disease-after-surgical-mitral-valve-repair
#2
Matteo Augello, Luca Lanzarini
We describe the case of a 46-year old female with a Barlow's disease (MVP) characterized by systolic curling of posterior left ventricular (LV) wall + significant mitral annular disjunction + complex ventricular arrhythmias + syncope + inverted T waves in inferolateral leads in whom a successful surgical mitral valve rapair determined the disappearance not only of the echocardiographic but also the electrocar-diographic abnormalities (in particular the inferolateral T waves inversion on basal electrocardiogram and the complex basal arrhythmic pattern)...
April 6, 2017: Clinics and Practice
https://www.readbyqxmd.com/read/28431144/effect-of-body-mass-index-on-venous-sinus-pressures-in-idiopathic-intracranial-hypertension-patients-before-and-after-endovascular-stenting
#3
Daniel M S Raper, Dale Ding, Thomas J Buell, R Webster Crowley, Robert M Starke, Kenneth C Liu
BACKGROUND: Elevated body mass index (BMI) has been correlated with worse outcomes after treatment for idiopathic intracranial hypertension (IIH). Venous sinus stenting (VSS) has emerged as a safe and effective treatment for a subset of patients with IIH and evidence of venous sinus stenosis. However, the association between BMI and the efficacy of VSS remains poorly characterized. OBJECTIVE: To determine, in a retrospective cohort study, the effect of BMI on preoperative mean intracranial venous pressure (MVP) and post-VSS outcomes...
April 20, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28415082/p210long-term-outcome-of-primary-mitral-valve-prolapse-results-from-a-population-of-250-patients-referred-to-a-tertiary-cardiovascular-center
#4
V Mecarocci, F Mori
Background: Outcome of Mitral Valve Prolapse (MVP) was controversial for long time. Many studies reported great differences in the incidence of cardiovascular events due, above all, to heterogeneous and small studied populations. Most of theme were also published to late '80 of the last century till early '00. Purpose: To make a contemporary survey on the incidence of cardiovascular events in a selected population of patients affected by primary MVP referred to a tertiary cardiovascular center for the medical and surgical care of valvular heart disease...
December 1, 2016: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28389690/energy-dynamics-of-the-intraventricular-vortex-after-mitral-valve-surgery
#5
Kouki Nakashima, Keiichi Itatani, Tadashi Kitamura, Norihiko Oka, Tetsuya Horai, Shohei Miyazaki, Masaki Nie, Kagami Miyaji
Mitral valve morphology after mitral valve surgery affects postoperative intraventricular flow patterns and long-term cardiac performance. We visualized ventricular flow by echocardiography vector flow mapping (VFM) to reveal the impact of different mitral valve procedures. Eleven cases of mechanical mitral valve replacement (nine in the anti-anatomical and two in the anatomical position), three bioprosthetic mitral valve replacements, and four mitral valve repairs were evaluated. The mean age at the procedure was 57...
April 7, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28385672/characterization-of-health-care-utilization-in-patients-receiving-implantable-cardioverter-defibrillator-therapies-an-analysis-of-the-managed-ventricular-pacing-trial
#6
John Rickard, David Whellen, Lou Sherfesee, Brett J Peterson, Tara Nahey, Anthony S Tang, Kenneth A Ellenbogen, Alan Cheng
BACKGROUND: Implantable cardioverter-defibrillators (ICDs) are effective in terminating lethal arrhythmias, but little is known about the degree of health care utilization (HCU) after ICD therapies. OBJECTIVE: Using data from the managed ventricular pacing trial, we sought to identify the incidence and types of HCU in ICD recipients after receiving ICD therapy (shocks or antitachycardia pacing [ATP]). METHODS: We analyzed HCU events (ventricular tachyarrhythmia [VTA]-related, heart failure-related, ICD implant procedure-related, ICD system-related, or other) and their association with ICD therapies (shocked ventricular tachycardia episode, ATP-terminated ventricular tachycardia episode, and inappropriately shocked episode)...
April 4, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28360352/intracranial-venous-pressures-under-conscious-sedation-and-general-anesthesia
#7
Daniel M S Raper, Thomas J Buell, Ching-Jen Chen, Dale Ding, Robert M Starke, Kenneth C Liu
INTRODUCTION: Venous outflow obstruction has been implicated in the pathophysiology of a subset of patients with idiopathic intracranial hypertension (IIH), and venous sinus stenting (VSS) has emerged as an effective treatment. However, the effect of anesthesia on venous sinus pressure measurements is unpredictable. A more thorough understanding of the effect of the level of anesthesia on intracranial venous pressures might help to better define patients who might benefit most from stent placement...
March 30, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/28338447/vein-of-galen-malformation-treated-with-the-micro-vascular-plug-system-case-report
#8
Woojin Joo, Philippe Mercier, Shiva Kheradmand, Peyman Shirani, Ahmed Sarhan, Samer K Elbabaa, Randall C Edgell
This case report describes the use of the Micro Vascular Plug (MVP) system in a mural-type vein of Galen aneurysmal malformation, resulting in successful occlusion of the cerebrovascular fistula. This result was confirmed with immediate cessation in blood flow and 6-month follow-up angiography. The unique characteristics of the MVP provide potential advantages over current embolic techniques for occlusion of high-flow, fistulous, intracranial vessels such as those seen in the vein of Galen aneurysmal malformation, and may represent a valuable addition to the currently available options...
March 24, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/28333318/a-phase-iii-randomized-controlled-trial-comparing-the-efficacy-safety-and-tolerability-of-oral-dydrogesterone-versus-micronized-vaginal-progesterone-for-luteal-support-in-in-vitro-fertilization
#9
Herman Tournaye, Gennady T Sukhikh, Elke Kahler, Georg Griesinger
STUDY QUESTION: Is oral dydrogesterone 30 mg daily (10 mg three times daily [TID]) non-inferior to micronized vaginal progesterone (MVP) 600 mg daily (200 mg TID) for luteal support in in vitro fertilization (IVF), assessed by the presence of fetal heartbeats determined by transvaginal ultrasound at 12 weeks of gestation? SUMMARY ANSWER: Non-inferiority of oral dydrogesterone versus MVP was demonstrated at 12 weeks of gestation, with a difference in pregnancy rate and an associated confidence interval (CI) that were both within the non-inferiority margin...
May 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28322321/the-clinical-effect-of-nicorandil-on-perioperative-myocardial-protection-in-patients-undergoing-elective-pci-a-systematic-review-and-meta-analysis
#10
Ziliang Ye, Qiang Su, Lang Li
Many scholars have studied the effect of nicorandil on perioperative myocardial protection in patients undergoing elective percutaneous coronary intervention (PCI), but results are inconsistent. Therefore, we performed this meta-analysis. Finally, 16 articles, including 1616 patients, were included into this meta-analysis. Meta-analysis results showed that: (1) Nicorandil can reduce the level of CK-MB after PCI, including at 6 hours, 12 hours, 18 hours and 24 hours. (2) Nicorandil can reduce the level of TnT after PCI, including at 6 hours, 12 hours, 18 hours and 24 hours...
March 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28298056/outcomes-after-biologically-augmented-isolated-meniscal-repair-with-marrow-venting-are-comparable-with-those-after-meniscal-repair-with-concomitant-anterior-cruciate-ligament-reconstruction
#11
Chase S Dean, Jorge Chahla, Lauren M Matheny, Justin J Mitchell, Robert F LaPrade
BACKGROUND: Meniscal repair in the setting of anterior cruciate ligament (ACL) reconstruction has demonstrated superior outcomes compared with isolated meniscal repair. Limited evidence exists for the effects of biological augmentation in isolated meniscal repair, particularly as compared with meniscal repair with concomitant ACL reconstruction. Purpose/Hypothesis: The purpose of this study was to compare the outcomes and survivorship of meniscal repair in 2 cohorts of patients: meniscal repair with biological augmentation using a marrow venting procedure (MVP) of the intercondylar notch, and meniscal repair with concomitant ACL reconstruction...
May 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28291938/validation-of-a-modern-second-check-dosimetry-system-using-a-novel-verification-phantom
#12
Daniel G McDonald, Dustin J Jacqmin, Christopher J Mart, Nicholas C Koch, Jean L Peng, Michael S Ashenafi, Mario A Fugal, Kenneth N Vanek
PURPOSE: To evaluate the Mobius second-check dosimetry system by comparing it to ionization-chamber dose measurements collected in the recently released Mobius Verification Phantom™ (MVP). For reference, a comparison of these measurements to dose calculated in the primary treatment planning system (TPS), Varian Eclipse with the AcurosXB dose algorithm, is also provided. Finally, patient dose calculated in Mobius is compared directly to Eclipse to demonstrate typical expected results during clinical use of the Mobius system...
January 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28287680/the-real-mvp-in-youth-sports-the-general-pediatrician
#13
EDITORIAL
Cynthia R LaBella
No abstract text is available yet for this article.
March 1, 2017: Pediatric Annals
https://www.readbyqxmd.com/read/28273590/upregulation-of-breast-cancer-resistance-protein-and-major-vault-protein-in-drug-resistant-epilepsy
#14
Aparna Banerjee Dixit, Devina Sharma, Arpna Srivastava, Jyotirmoy Banerjee, Manjari Tripathi, Deepak Prakash, P Sarat Chandra
PURPOSE: Identifying factors involved in the development of drug resistant epilepsy (DRE) remains a challenge. Candidate gene studies have shown modulation of resistance to drugs by various multidrug resistance proteins in DRE. However the resistance to drugs in DRE could be more complex and multifactorial involving molecules in different pharmacokinetic processes. In this study for the first time we have analyzed the relative expression of four molecules with different drug resistance mechanisms in two most common DRE pathologies, mesial temporal lobe epilepsy (MTLE) and focal cortical dysplasia (FCD) with respect to each other and also with different non-epileptic controls...
April 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28265575/proteomic-analysis-of-fetal-ovaries-reveals-that-primordial-follicle-formation-and-transition-are-differentially-regulated
#15
Mengmeng Xu, Long Che, Zhenguo Yang, Pan Zhang, Jiankai Shi, Jian Li, Yan Lin, Zhengfeng Fang, Lianqiang Che, Bin Feng, De Wu, Shengyu Xu
Primordial follicle formation represents a critical phase of the initiation of embryonic reproductive organ development, while the primordial follicle transition into primary follicle determines whether oestrus or ovulation will occur in female animals. To identify molecular mechanism of new proteins which are involved in ovarian development, we employed 2D-DIGE to compare the protein expression profiles of primordial follicles and primary follicles of fetal ovaries in pigs. Fetal ovaries were collected at distinct time-points of the gestation cycle (g55 and g90)...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28261377/identification-of-patients-affected-by-mitral-valve-prolapse-with-severe-regurgitation-a-multivariable-regression-model
#16
Paola Songia, Benedetta Porro, Mattia Chiesa, Veronika Myasoedova, Francesco Alamanni, Elena Tremoli, Paolo Poggio
Background. Mitral valve prolapse (MVP) is the most common cause of severe mitral regurgitation. Besides echocardiography, up to now there are no reliable biomarkers available for the identification of this pathology. We aim to generate a predictive model, based on circulating biomarkers, able to identify MVP patients with the highest accuracy. Methods. We analysed 43 patients who underwent mitral valve repair due to MVP and compared to 29 matched controls. We assessed the oxidative stress status measuring the oxidized and the reduced form of glutathione by liquid chromatography-tandem mass spectrometry method...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28251633/outcome-of-pregnancy-in-women-diagnosed-with-idiopathic-polyhydramnios
#17
Sarwat Khan, Jennifer Donnelly
INTRODUCTION: Polyhydramnios is present in approximately 2% of pregnancies and it has been associated with a variety of adverse pregnancy outcomes. OBJECTIVES: The aim of our study was to evaluate the association between polyhydramnios and adverse pregnancy outcomes. METHODS: This was a retrospective case control study of 288 singleton pregnancies delivered in the Rotunda Hospital, Dublin, between 2013 and 2014. Polyhydramnios was defined as: (i) amniotic fluid index (AFI) ≥ 25 cm; (ii) maximal vertical pocket (MVP) of ≥8 cm; and (iii) a gestational age-specific threshold for AFI...
February 2017: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28243397/effect-of-fluoxetine-administration-on-clinical-and-echocardiographic-findings-in-patients-with-mitral-valve-prolapse-and-generalized-anxiety-disorder-randomized-clinical-trial
#18
Reza Jafarzadeh Esfehani, Homan Kamranian, Majid Jalalyazdi
BACKGROUND: Mitral valve prolapse (MVP) is accompanied by mental disorders including anxiety, which has similar presentations as MVP. It is hypothesised that treatment of anxiety might reduce the symptoms of MVP. OBJECTIVE: The aim of this study was to assess the clinical and echocardiographic effects of fluoxetine administration in patients with MVP and anxiety. METHODS: This randomized clinical trial was conducted on patients with documented MVP and generalised anxiety disorder (GAD) who were referred to Mashhad University of Medical Sciences cardiology clinics, Mashhad, Iran in 2015...
January 2017: Electronic Physician
https://www.readbyqxmd.com/read/28219921/predictive-value-of-dobutamine-stress-perfusion-echocardiography-in-contemporary-end-stage-liver-disease
#19
Bipul Baibhav, Chetaj A Mahabir, Feng Xie, Valerie K Shostrom, Timothy M McCashland, Thomas R Porter
BACKGROUND: The assessment of cardiac risk in contemporary liver transplantation (LT) has required more sensitive testing for the detection of occult coronary artery disease as well as microvascular and functional cardiac abnormalities. Because dobutamine stress perfusion echocardiography provides an assessment of both regional systolic and diastolic function as well as microvascular perfusion (MVP), we sought to examine its incremental value in this setting. METHODS AND RESULTS: We evaluated the predictive value of dobutamine stress perfusion echocardiography in 296 adult patients with end-stage liver disease and preserved systolic function who underwent LT between 2008 and 2014...
February 20, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28211508/mvp-mediated-exosomal-sorting-of-mir-193a-promotes-colon-cancer-progression
#20
Yun Teng, Yi Ren, Xin Hu, Jingyao Mu, Abhilash Samykutty, Xiaoying Zhuang, Zhongbin Deng, Anil Kumar, Lifeng Zhang, Michael L Merchant, Jun Yan, Donald M Miller, Huang-Ge Zhang
Exosomes are emerging mediators of intercellular communication; whether the release of exosomes has an effect on the exosome donor cells in addition to the recipient cells has not been investigated to any extent. Here, we examine different exosomal miRNA expression profiles in primary mouse colon tumour, liver metastasis of colon cancer and naive colon tissues. In more advanced disease, higher levels of tumour suppressor miRNAs are encapsulated in the exosomes. miR-193a interacts with major vault protein (MVP)...
February 17, 2017: Nature Communications
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