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Drew A Torigian, Judith Green-McKenzie, Xianling Liu, Frances S Shofer, Thomas Werner, Catherine E Smith, Andrew A Strasser, Mateen C Moghbel, Ami H Parekh, Grace Choi, Marcus D Goncalves, Natalie Spaccarelli, Saied Gholami, Prithvi S Kumar, Yubing Tong, Jayaram K Udupa, Clementina Mesaros, Abass Alavi
RATIONALE AND OBJECTIVES: The aim of this study was to assess the feasibility of (18)F-fluorodeoxyglucose (FDG)-positron emission tomography/computed tomography (PET/CT) to systematically detect and quantify differential effects of chronic tobacco use in organs of the whole body. MATERIALS AND METHODS: Twenty healthy male subjects (10 nonsmokers and 10 chronic heavy smokers) were enrolled. Subjects underwent whole-body FDG-PET/CT, diagnostic unenhanced chest CT, mini-mental state examination, urine testing for oxidative stress, and serum testing...
October 18, 2016: Academic Radiology
Radosław Januchowski, Karolina Sterzyńska, Katarzyna Zaorska, Patrycja Sosińska, Andrzej Klejewski, Maciej Brązert, Michał Nowicki, Maciej Zabel
BACKGROUND: Multiple drug resistance (MDR) of cancer cells is the main reason of intrinsic or acquired insensitivity to chemotherapy in many cancers. In this study we used ovarian cancer model of acquired drug resistance to study development of MDR. We have developed eight drug resistant cell lines from A2780 ovarian cancer cell line: two cell lines resistant to each drug commonly used in ovarian cancer chemotherapy: cisplatin (CIS), paclitaxel (PAC), doxorubicin (DOX) and topotecan (TOP)...
October 18, 2016: Journal of Ovarian Research
Shota Fukuda, Jae-Kwan Song, Keitaro Mahara, Hiroshi Kuwaki, Jeong Yoon Jang, Masaaki Takeuchi, Byung Joo Sun, Yun Jeong Kim, Tetsu Miyamoto, Yasushi Oginosawa, Shinjo Sonoda, Masataka Eto, Yosuke Nishimura, Shuichiro Takanashi, Robert A Levine, Yutaka Otsuji
BACKGROUND: Prominent mitral valve (MV) annular dilatation with only modest left ventricular (LV) dilatation in patients with MV prolapse (MVP) suggests predominant dilatation in adjacent basal LV, which may augment regional wall tension and attenuate contraction by Laplace's law. We hypothesized that MV annular dilatation in patients with MVP is associated with the basal predominance of LV dilatation and attenuated contraction, which can be altered by surgical MV plasty with annulus reduction...
October 2016: Circulation. Cardiovascular Imaging
N D N Rodrigues, M Staniforth, J D Young, Y Peperstraete, N C Cole-Filipiak, J R Gord, P S Walsh, D M Hewett, T S Zwier, V G Stavros
Ultrafast time-resolved ion yield (TR-IY) and velocity map imaging spectroscopies are employed to reveal the relaxation dynamics after photoexcitation in ethyl 4-hydroxy-3-methoxycinnamate (ethyl ferulate, EF), an active ingredient in commercially available sunscreens. In keeping with a bottom-up strategy, the building blocks of EF, 2-methoxy-4-vinylphenol (MVP) and 4-hydroxy-3-methoxycinnamyl alcohol (coniferyl alcohol, ConA), were also studied to assist in our understanding of the dynamics of EF as we build up in molecular complexity...
September 16, 2016: Faraday Discussions
Rahul Kumar Sevakula, Nishchal Kumar Verma
Classification algorithms have been traditionally designed to simultaneously reduce errors caused by bias as well by variance. However, there occur many situations where low generalization error becomes extremely crucial to getting tangible classification solutions, and even slight overfitting causes serious consequences in the test results. In such situations, classifiers with low Vapnik-Chervonenkis (VC) dimension can bring out positive differences due to two main advantages: 1) the classifier manages to keep the test error close to training error and 2) the classifier learns effectively with small number of samples...
September 30, 2016: IEEE Transactions on Neural Networks and Learning Systems
Elisa M Vuorinen, Nina K Rajala, Hanna E Rauhala, Anssi T Nurminen, Vesa P Hytönen, Anne Kallioniemi
Karyopherin alpha 7 (KPNA7) belongs to a family of nuclear import proteins that recognize and bind nuclear localization signals (NLSs) in proteins to be transported to the nucleus. Previously we found that KPNA7 is overexpressed in a subset of pancreatic cancer cell lines and acts as a critical regulator of growth in these cells. This characteristic of KPNA7 is likely to be mediated by its cargo proteins that are still mainly unknown. Here, we used protein affinity chromatography in Hs700T and MIA PaCa-2 pancreatic cancer cell lines and identified 377 putative KPNA7 cargo proteins, most of which were known or predicted to localize to the nucleus...
September 21, 2016: Biochimica et Biophysica Acta
Wen-Jian Jiang, Wei-Guo Ma, Xiao-Long Wang, Yu-Yong Liu, Jun-Ming Zhu, Li-Zhong Sun, Hong-Jia Zhang
OBJECTIVE: Mitral regurgitation is common in patients with aortic root aneurysm. Mitral valve repair (MVP) or replacement (MVR) can be performed for these patients through either a transverse aortotomy (TA) or transseptal approach (TS). This study sought to compare the early outcomes of mitral valve surgery through the TA and TS approaches and decide which is optimal for this subset of patients. METHODS: Between March 2013 and April 2015, we operated on 99 patients (81 males, 81...
November 15, 2016: International Journal of Cardiology
Dimitri Boiroux, Tinna Björk Aradóttir, Kirsten Nørgaard, Niels Kjølstad Poulsen, Henrik Madsen, John Bagterp Jørgensen
BACKGROUND: Bolus calculators help patients with type 1 diabetes to mitigate the effect of meals on their blood glucose by administering a large amount of insulin at mealtime. Intraindividual changes in patients physiology and nonlinearity in insulin-glucose dynamics pose a challenge to the accuracy of such calculators. METHOD: We propose a method based on a continuous-discrete unscented Kalman filter to continuously track the postprandial glucose dynamics and the insulin sensitivity...
September 8, 2016: Journal of Diabetes Science and Technology
Vijayendra Dasari, Andrea Schuessler, Corey Smith, Yide Wong, John J Miles, Mark J Smyth, George Ambalathingal, Ross Francis, Scott Campbell, Daniel Chambers, Rajiv Khanna
Viral infections including cytomegalovirus, Epstein-Barr virus, adenovirus, and BK virus are a common and predictable problem in transplant recipients. While cellular immune therapies have been successfully used to tackle infectious complications in transplant recipients, manufacturing immunotherapies to address the multitude of possible pathogens can be technically challenging and labor-intensive. Here we describe a novel adenoviral antigen presentation platform (Ad-MvP) as a tool for rapid generation of multivirus-specific T-cells in a single step...
2016: Molecular Therapy. Methods & Clinical Development
Chun-Na Jin, Ivan S Salgo, Robert J Schneider, Kevin Ka-Ho Kam, Wai-Kin Chi, Chak-Yu So, Zhe Tang, Song Wan, Randolph Wong, Malcolm Underwood, Alex Pui-Wai Lee
BACKGROUND: Accurate localization of mitral valve prolapse (MVP) is crucial for surgical planning. Despite improved visualization of the mitral valve by three-dimensional transesophageal echocardiography, image interpretation remains expertise dependent. Manual construction of mitral valve topographic maps improves diagnostic accuracy but is time-consuming and requires substantial manual input. A novel computer-learning technique called Anatomical Intelligence in ultrasound (AIUS) semiautomatically tracks the annulus and leaflet anatomy for parametric analysis...
October 2016: Journal of the American Society of Echocardiography
Necati Duru, Oğuz Erman Haşhaş, Emre Göktaş, Zeynep Duru, Hasan Basri Arifoğlu, Döndü Melek Ulusoy, Arzu Seyhan Karatepe Haşhaş, Mustafa Ataş
OBJECTIVES: The aim of this study was to compare the thickness of each corneal sublayer in patients with mitral valve prolapse (MVP) and healthy individuals. METHODS: A total of 38 eyes from 38 patients with MVP and 34 eyes from 34 age- and sex-matched healthy individuals were included in this study. The thickness of the corneal epithelium, Bowman layer, stroma, and Descemet membrane-endothelium complex were measured on the central cornea (i.e., corneal apex) and both the inferior and superior halves of the cornea with anterior segment module of spectral domain optical coherence tomography...
July 12, 2016: Eye & Contact Lens
Hong-TaoYuan, Mei Yang, Li Zhong, Ying-Hsiang Lee, Vaibhav R Vaidya, Samuel J Asirvatham, Michael J Ackerman, Sorin V Pislaru, Rakesh M Suri, Joshua P Slusser, David O Hodge, Yu-Tang Wang, Yong-Mei Cha
BACKGROUND: In patients with frequent premature ventricular contractions (PVCs), little is known about the profile of PVCs and the outcome of treatment in patients with mitral valve prolapse (MVP) compared to those without MVP. METHODS AND RESULTS: Patients with documented PVCs between January 2001 and October 2012 were divided into 2 groups: MVP and non-MVP. The PVC characteristics, efficacy of therapy, and outcome were compared between the 2 groups. A total of 112 patients with MVP and 952 without MVP were identified...
October 15, 2016: International Journal of Cardiology
Martina Perazzolo Marra, Cristina Basso, Manuel De Lazzari, Stefania Rizzo, Alberto Cipriani, Benedetta Giorgi, Carmelo Lacognata, Ilaria Rigato, Federico Migliore, Kalliopi Pilichou, Luisa Cacciavillani, Emanuele Bertaglia, Anna Chiara Frigo, Barbara Bauce, Domenico Corrado, Gaetano Thiene, Sabino Iliceto
BACKGROUND: Arrhythmic mitral valve prolapse (MVP) is characterized by myxomatous leaflets and left ventricular (LV) fibrosis of papillary muscles and inferobasal wall. We searched for morphofunctional abnormalities of the mitral valve that could explain a regional mechanical myocardial stretch. METHODS AND RESULTS: Thirty-six (27 female patients; median age: 44 years) arrhythmic MVP patients with LV late gadolinium enhancement on cardiac magnetic resonance and no or trivial mitral regurgitation, and 16 (6 female patients; median age: 40 years) MVP patients without LV late gadolinium enhancement were investigated by morphofunctional cardiac magnetic resonance...
August 2016: Circulation. Cardiovascular Imaging
An H Bui, Sébastien Roujol, Murilo Foppa, Kraig V Kissinger, Beth Goddu, Thomas H Hauser, Peter J Zimetbaum, Long H Ngo, Warren J Manning, Reza Nezafat, Francesca N Delling
OBJECTIVE: We aimed to investigate the association of diffuse myocardial fibrosis by cardiac magnetic resonance (CMR) T1 with complex ventricular arrhythmia (ComVA) in mitral valve prolapse (MVP). METHODS: A retrospective analysis was performed on 41 consecutive patients with MVP referred for CMR between 2006 and 2011, and 31 healthy controls. Arrhythmia analysis was available in 23 patients with MVP with Holter/event monitors. Left ventricular (LV) septal T1 times were derived from Look-Locker sequences after administration of 0...
August 11, 2016: Heart: Official Journal of the British Cardiac Society
Nikolaas N Oosterhof, Andrew C Connolly, James V Haxby
Recent years have seen an increase in the popularity of multivariate pattern (MVP) analysis of functional magnetic resonance (fMRI) data, and, to a much lesser extent, magneto- and electro-encephalography (M/EEG) data. We present CoSMoMVPA, a lightweight MVPA (MVP analysis) toolbox implemented in the intersection of the Matlab and GNU Octave languages, that treats both fMRI and M/EEG data as first-class citizens. CoSMoMVPA supports all state-of-the-art MVP analysis techniques, including searchlight analyses, classification, correlations, representational similarity analysis, and the time generalization method...
2016: Frontiers in Neuroinformatics
Chien-Jung Chang, Ya-Chu Chen, Chih-Hsien Lee, Ing-Fang Yang, Ten-Fang Yang
BACKGROUND: Heart rate variability (HRV) has been shown to be a useful measure of autonomic activity in healthy and mitral valve prolapsed (MVP) subjects. However, the effects of posture and gender on HRV in symptomatic MVP and normal adults had not been elucidated in Taiwan. METHODS: A total of 118 MVP patients (7 males, 39 ± 7 years old; and 111 females, 42 ± 13 years old) and 148 healthy control (54 males, 28 ± 4 years old; and 94 females, 26 ± 6 years old) were investigated...
July 2016: Acta Cardiol Sin
Konstantinos Dean Boudoulas, Antonios A Pitsis, Harisios Boudoulas
Mitral valve prolapse (MVP) results from the systolic movement of a portion(s) or segment(s) of the mitral valve leaflet(s) into the left atrium during left ventricular (LV) systole. It should be emphasised that MVP alone, as defined by imaging techniques, may comprise a non-specific finding because it also depends on the LV volume, myocardial contractility and other LV hemodynamics. Thus, a floppy mitral valve (FMV) should be the basis for the diagnosis of MVP. Two types of symptoms may be defined in these patients...
March 2016: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
R L Washington, B Goldberg
In brief Mitral valve prolapse (MVP) often brief manifests among active children and adolescents. Techniques for detecting clicks and systolic nonejection murmurs can help physicians identify MVP, and diagnostic tests can help confirm the findings. Tracking the patient's chest pain, palpitations, shortness of breath, and other symptoms can help clinicians decide if treatment should include medication-and if medication helps symptoms. Sometimes, simple reassurance will be enough to ease symptoms. With annual follow-up, patients can lead normal lives, which includes reaping the benefits of physical activity...
January 1993: Physician and Sportsmedicine
Leslie A Sadownik, Kelly B Smith, Amber Hui, Lori A Brotto
This study explored the experiences of male partners of women with dyspareunia, secondary to provoked vestibulodynia (PVD), who participated in the Multidisciplinary Vulvodynia Program (MVP). Participants were 16 men between 22 and 45 years of age. Data was collected with semi-structured interviews and analyzed using content analysis. Men were interviewed about: (1) the impact of the woman's PVD on themselves; and (2) the impact of the MVP on themselves. Participants experienced negative psychological effects (e...
July 11, 2016: Journal of Sex & Marital Therapy
Younes Boudjemline
OBJECTIVES: To evaluate the safety, feasibility, and efficacy of the MVP™ microvascular plug(Covidien) for closure of vascular anomalies in patients with congenital heart diseases (CHD). BACKGROUND: The MVP™ is a novel device with PTFE integrated. The device has been recently introduced in the radiological field and reported exclusively for neurological anomalies. METHODS: All CHD patients receiving the device from April 2015 until July 2015 were included in the study and followed up clinically as well as by transthoracic echocardiography...
July 9, 2016: Catheterization and Cardiovascular Interventions
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