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https://www.readbyqxmd.com/read/27914795/insulin-use-adipokine-profiles-and-breast-cancer-prognosis
#1
Zachary A P Wintrob, Jeffrey P Hammel, Thaer Khoury, George K Nimako, Hsin-Wei Fu, Zahra S Fayazi, Dan P Gaile, Alan Forrest, Alice C Ceacareanu
BACKGROUND: Type-2 diabetes mellitus (T2DM) and breast cancer (BC) share common cytokine signaling changes resultant from adipose tissue dysfunction. This modified adipokine signaling was shown to be directly associated with changes in the body mass index (BMI) and diet and it is expected to also be influenced by T2DM pharmacotherapy. We evaluated the relationship between pre-existing diabetes treatment, circulating adipokine levels at cancer diagnosis, and long-term outcomes. METHODS: All incident BC cases were reviewed (01/01/2003-12/31/2009, N=2194)...
November 30, 2016: Cytokine
https://www.readbyqxmd.com/read/27888552/initial-clinical-experience-with-the-medtronic-micro-vascular-plug%C3%A2-in-transcatheter-occlusion-of-pdas-in-extremely-premature-infants
#2
Shyam Sathanandam, Henri Justino, B Rush Waller, Wolfgang Radtke, Athar M Qureshi
OBJECTIVES: To describe the early multicenter, clinical experience with the Medtronic Micro Vascular Plug™ (MVP) for the occlusion of patent ductus arteriosus (PDA) in premature infants. BACKGROUND: The MVP is a large diameter plug that can be delivered through a microcatheter for occlusion of abnormal blood vessels. METHODS: A Retrospective review of PDA embolization procedures performed in two centers using the MVP was performed. RESULTS: Fifteen premature infants underwent attempted PDA occlusion using the MVP...
November 26, 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/27860173/novel-use-of-the-medtronic-micro-vascular-plug-for-pda-closure-in-preterm-infants
#3
Elizabeth W Wang-Giuffre, John P Breinholt
OBJECTIVES: To describe a single institution experience with a new endovascular occlusion device used for transcatheter patent ductus arteriosus (PDA) closure in preterm infants. BACKGROUND: The PDA is a defect largely treated via cardiac catheterization except for the smallest patients. METHODS: Medical records and catheterization reports of all premature neonates who underwent PDA device closure with the Medtronic Micro Vascular Plug (MVP) (Medtronic, Minneapolis, MN) between September 2015 and June 2016 were reviewed...
November 10, 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/27829586/left-atrial-remodeling-in-segmental-vs-global-mitral-valve-prolapse%C3%A3-three-dimensional-echocardiography
#4
Atsushi Hayashi, Shota Fukuda, Keitaro Mahara, Soshi Hei, Takeshi Onoue, Yuichiro Kado, Yasufumi Nagata, Mai Iwataki, Kyoko Otani, Tetsu Miyamoto, Yasushi Oginosawa, Shinjo Sonoda, Masataka Eto, Yosuke Nishimura, Shuichiro Takanashi, Robert A Levine, Yutaka Otsuji
BACKGROUND: Segmental and global mitral valve prolapse (MVP) comprise 2 representative phenotypes in this syndrome. While mitral regurgitation (MR) severity is a major factor causing left atrial (LA) remodeling in MVP, prominent mitral valve (MV) annulus dilatation in global MVP may specifically cause inferiorly predominant LA remodeling. We compared MV annulus and LA geometry in patients with segmental and global MVP.Methods and Results:LA volume as well as inferior, middle, and superior LA cross-sectional areas (CSA) were measured on 3-D echocardiography in 20 controls, in 40 patients with segmental MVP, and in 18 with global MVP...
November 9, 2016: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/27817195/mechanisms-underlying-lung-resistance-related-protein-lrp-mediated-doxorubicin-resistance-of-non-small-cell-lung-cancer-cells
#5
Yu-Lun Chen, Tsung-Ying Yang, Chieh-Liang Wu, Kun-Chieh Chen, Shih-Lan Hsu, Chi-Mei Hsueh
Lung resistance-related protein (LRP) is a human major vault protein (MVP) implicated in drug resistance of cancer cells in a cell-type dependent manner. The primary goal of the study was to understand the role(s) of LRP in doxorubicin (DOX) resistance of non-small cell lung cancer (NSCLC) cells and the underlying working mechanisms. In the study, the roles of LRP in the regulation of DOX dynamics, nuclear import of minor vault proteins (vPARP and TEP1) and DOX-mediated cytotoxicity were examined in CH27 and H460 cells...
December 31, 2016: Chinese Journal of Physiology
https://www.readbyqxmd.com/read/27813028/the-role-of-serial-fdg-pet-for-assessing-therapeutic-response-in-patients-with-cardiac-sarcoidosis
#6
Pei-Ing Lee, Gang Cheng, Abass Alavi
BACKGROUND: The purpose of this study was to determine the feasibility of serial quantitative 2-deoxy-2-[18F]fluoro-D-glucose (FDG) positron emission tomography (PET) to monitor the response of cardiac sarcoidosis to treatment. METHODS AND RESULTS: A total of 38 PET scan intervals (54 PET scans) were obtained in 16 patients with cardiac sarcoidosis who underwent serial FDG PET during treatment. FDG-avid lesions of the heart were interpreted quantitatively using 4 PET parameters: maximum standardized uptake value (SUVmax), partial volume corrected mean standardized uptake value (SUVmean), partial volume corrected metabolic volume product (MVP), and global metabolic volume product (gMVP)...
November 3, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27812780/pulmonary-arteriovenous-malformations-embolized-using-a-micro-vascular-plug-system-technical-note-on-a-preliminary-experience
#7
Eanuele Boatta, Christine Jahn, Matthieu Canuet, Julien Garnon, Nitin Ramamurthy, Roberto Luigi Cazzato, Afshin Gangi
AIM: To report our preliminary experience using a Micro Vascular Plug (MVP) deployed through a 2.8Fr micro-catheter for the treatment of pulmonary arteriovenous malformations (PAVMs) in a cohort of patients affected by Hereditary Haemorrhagic Telangiectasia (HHT). MATERIALS AND METHODS: Four consecutive female patients (mean age 38.0 years; range 25-55 years) with PAVMs diagnosed on echocardiogram/bubble test and contrast-enhanced CT (CECT) underwent MVP embolization...
November 3, 2016: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/27807004/endothelial-cell-hypertrophy-and-microvascular-proliferation-in-meningiomas-are-correlated-with-higher-histological-grade-and-shorter-progression-free-survival
#8
Catherine Ling, Celso Pouget, Fabien Rech, Robin Pflaum, Mathilde Treffel, Franck Bielle, Karima Mokhtari, Jean-Matthieu Casse, Jean-Michel Vignaud, Michel Kalamarides, Matthieu Peyre, Guillaume Gauchotte
Microvascular proliferation (MVP) is a hallmark of glioblastoma. Endothelial cell hypertrophy (ECH), also known as endothelial hyperplasia, is correlated with a shorter survival of patients with gliomas. However, the prognostic value of these 2 morphological features has not been studied in meningiomas. The aim of this study was to evaluate the prognostic value of angiogenesis in meningiomas, most notably ECH, MVP, and microvascular density, which were evaluated using immunohistochemistry with antibodies against CD34 and CD105 (a marker of neovascularization) in a series of 139 meningiomas...
November 2, 2016: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/27789563/reduction-in-unnecessary-ventricular-pacing-fails-to-affect-hard-clinical-outcomes-in-patients-with-preserved-left-ventricular-function-a-meta-analysis
#9
Mohammed Shurrab, Jeff S Healey, Saleem Haj-Yahia, Anna Kaoutskaia, Giuseppe Boriani, Aldo Carrizo, Gianluca Botto, David Newman, Luigi Padeletti, Stuart J Connolly, Eugene Crystal
AIMS: Several pacing modalities across multiple manufacturers have been introduced to minimize unnecessary right ventricular pacing. We conducted a meta-analysis to assess whether ventricular pacing reduction modalities (VPRM) influence hard clinical outcomes in comparison to standard dual-chamber pacing (DDD). METHODS AND RESULTS: An electronic search was performed using Cochrane Central Register, PubMed, Embase, and Scopus. Only randomized controlled trials (RCT) were included in this analysis...
October 26, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/27769824/a-study-of-the-feasibility-of-fdg-pet-ct-to-systematically-detect-and-quantify-differential-metabolic-effects-of-chronic-tobacco-use-in-organs-of-the-whole-body-a-prospective-pilot-study
#10
Drew A Torigian, Judith Green-McKenzie, Xianling Liu, Frances S Shofer, Thomas Werner, Catherine E Smith, Andrew A Strasser, Mateen C Moghbel, Ami H Parekh, Grace Choi, Marcus D Goncalves, Natalie Spaccarelli, Saied Gholami, Prithvi S Kumar, Yubing Tong, Jayaram K Udupa, Clementina Mesaros, Abass Alavi
RATIONALE AND OBJECTIVES: The aim of this study was to assess the feasibility of (18)F-fluorodeoxyglucose (FDG)-positron emission tomography/computed tomography (PET/CT) to systematically detect and quantify differential effects of chronic tobacco use in organs of the whole body. MATERIALS AND METHODS: Twenty healthy male subjects (10 nonsmokers and 10 chronic heavy smokers) were enrolled. Subjects underwent whole-body FDG-PET/CT, diagnostic unenhanced chest CT, mini-mental state examination, urine testing for oxidative stress, and serum testing...
October 18, 2016: Academic Radiology
https://www.readbyqxmd.com/read/27756418/analysis-of-mdr-genes-expression-and-cross-resistance-in-eight-drug-resistant-ovarian-cancer-cell-lines
#11
Radosław Januchowski, Karolina Sterzyńska, Katarzyna Zaorska, Patrycja Sosińska, Andrzej Klejewski, Maciej Brązert, Michał Nowicki, Maciej Zabel
BACKGROUND: Multiple drug resistance (MDR) of cancer cells is the main reason of intrinsic or acquired insensitivity to chemotherapy in many cancers. In this study we used ovarian cancer model of acquired drug resistance to study development of MDR. We have developed eight drug resistant cell lines from A2780 ovarian cancer cell line: two cell lines resistant to each drug commonly used in ovarian cancer chemotherapy: cisplatin (CIS), paclitaxel (PAC), doxorubicin (DOX) and topotecan (TOP)...
October 18, 2016: Journal of Ovarian Research
https://www.readbyqxmd.com/read/27729364/basal-left-ventricular-dilatation-and-reduced-contraction-in-patients-with-mitral-valve-prolapse-can-be-secondary-to-annular-dilatation-preoperative-and-postoperative-speckle-tracking-echocardiographic-study-on-left-ventricle-and-mitral-valve-annulus-interaction
#12
Shota Fukuda, Jae-Kwan Song, Keitaro Mahara, Hiroshi Kuwaki, Jeong Yoon Jang, Masaaki Takeuchi, Byung Joo Sun, Yun Jeong Kim, Tetsu Miyamoto, Yasushi Oginosawa, Shinjo Sonoda, Masataka Eto, Yosuke Nishimura, Shuichiro Takanashi, Robert A Levine, Yutaka Otsuji
BACKGROUND: Prominent mitral valve (MV) annular dilatation with only modest left ventricular (LV) dilatation in patients with MV prolapse (MVP) suggests predominant dilatation in adjacent basal LV, which may augment regional wall tension and attenuate contraction by Laplace's law. We hypothesized that MV annular dilatation in patients with MVP is associated with the basal predominance of LV dilatation and attenuated contraction, which can be altered by surgical MV plasty with annulus reduction...
October 2016: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27711798/towards-elucidating-the-photochemistry-of-the-sunscreen-filter-ethyl-ferulate-using-time-resolved-gas-phase-spectroscopy
#13
N D N Rodrigues, M Staniforth, J D Young, Y Peperstraete, N C Cole-Filipiak, J R Gord, P S Walsh, D M Hewett, T S Zwier, V G Stavros
Ultrafast time-resolved ion yield (TR-IY) and velocity map imaging spectroscopies are employed to reveal the relaxation dynamics after photoexcitation in ethyl 4-hydroxy-3-methoxycinnamate (ethyl ferulate, EF), an active ingredient in commercially available sunscreens. In keeping with a bottom-up strategy, the building blocks of EF, 2-methoxy-4-vinylphenol (MVP) and 4-hydroxy-3-methoxycinnamyl alcohol (coniferyl alcohol, ConA), were also studied to assist in our understanding of the dynamics of EF as we build up in molecular complexity...
September 16, 2016: Faraday Discussions
https://www.readbyqxmd.com/read/27705867/assessing-generalization-ability-of-majority-vote-point-classifiers
#14
Rahul Kumar Sevakula, Nishchal Kumar Verma
Classification algorithms have been traditionally designed to simultaneously reduce errors caused by bias as well by variance. However, there occur many situations where low generalization error becomes extremely crucial to getting tangible classification solutions, and even slight overfitting causes serious consequences in the test results. In such situations, classifiers with low Vapnik-Chervonenkis (VC) dimension can bring out positive differences due to two main advantages: 1) the classifier manages to keep the test error close to training error and 2) the classifier learns effectively with small number of samples...
September 30, 2016: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/27664836/search-for-kpna7-cargo-proteins-in-human-cells-reveals-mvp-and-znf414-as-novel-regulators-of-cancer-cell-growth
#15
Elisa M Vuorinen, Nina K Rajala, Hanna E Rauhala, Anssi T Nurminen, Vesa P Hytönen, Anne Kallioniemi
Karyopherin alpha 7 (KPNA7) belongs to a family of nuclear import proteins that recognize and bind nuclear localization signals (NLSs) in proteins to be transported to the nucleus. Previously we found that KPNA7 is overexpressed in a subset of pancreatic cancer cell lines and acts as a critical regulator of growth in these cells. This characteristic of KPNA7 is likely to be mediated by its cargo proteins that are still mainly unknown. Here, we used protein affinity chromatography in Hs700T and MIA PaCa-2 pancreatic cancer cell lines and identified 377 putative KPNA7 cargo proteins, most of which were known or predicted to localize to the nucleus...
September 21, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27623017/surgery-for-mitral-regurgitation-in-patients-with-aortic-root-aneurysm-transaortic-or-transseptal-approach
#16
Wen-Jian Jiang, Wei-Guo Ma, Xiao-Long Wang, Yu-Yong Liu, Jun-Ming Zhu, Li-Zhong Sun, Hong-Jia Zhang
OBJECTIVE: Mitral regurgitation is common in patients with aortic root aneurysm. Mitral valve repair (MVP) or replacement (MVR) can be performed for these patients through either a transverse aortotomy (TA) or transseptal approach (TS). This study sought to compare the early outcomes of mitral valve surgery through the TA and TS approaches and decide which is optimal for this subset of patients. METHODS: Between March 2013 and April 2015, we operated on 99 patients (81 males, 81...
November 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27613658/an-adaptive-nonlinear-basal-bolus-calculator-for-patients-with-type-1-diabetes
#17
Dimitri Boiroux, Tinna Björk Aradóttir, Kirsten Nørgaard, Niels Kjølstad Poulsen, Henrik Madsen, John Bagterp Jørgensen
BACKGROUND: Bolus calculators help patients with type 1 diabetes to mitigate the effect of meals on their blood glucose by administering a large amount of insulin at mealtime. Intraindividual changes in patients physiology and nonlinearity in insulin-glucose dynamics pose a challenge to the accuracy of such calculators. METHOD: We propose a method based on a continuous-discrete unscented Kalman filter to continuously track the postprandial glucose dynamics and the insulin sensitivity...
September 8, 2016: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/27606351/prophylactic-and-therapeutic-adenoviral-vector-based-multivirus-specific-t-cell-immunotherapy-for-transplant-patients
#18
Vijayendra Dasari, Andrea Schuessler, Corey Smith, Yide Wong, John J Miles, Mark J Smyth, George Ambalathingal, Ross Francis, Scott Campbell, Daniel Chambers, Rajiv Khanna
Viral infections including cytomegalovirus, Epstein-Barr virus, adenovirus, and BK virus are a common and predictable problem in transplant recipients. While cellular immune therapies have been successfully used to tackle infectious complications in transplant recipients, manufacturing immunotherapies to address the multitude of possible pathogens can be technically challenging and labor-intensive. Here we describe a novel adenoviral antigen presentation platform (Ad-MvP) as a tool for rapid generation of multivirus-specific T-cells in a single step...
2016: Molecular Therapy. Methods & Clinical Development
https://www.readbyqxmd.com/read/27545445/using-anatomic-intelligence-to-localize-mitral-valve-prolapse-on-three-dimensional-echocardiography
#19
Chun-Na Jin, Ivan S Salgo, Robert J Schneider, Kevin Ka-Ho Kam, Wai-Kin Chi, Chak-Yu So, Zhe Tang, Song Wan, Randolph Wong, Malcolm Underwood, Alex Pui-Wai Lee
BACKGROUND: Accurate localization of mitral valve prolapse (MVP) is crucial for surgical planning. Despite improved visualization of the mitral valve by three-dimensional transesophageal echocardiography, image interpretation remains expertise dependent. Manual construction of mitral valve topographic maps improves diagnostic accuracy but is time-consuming and requires substantial manual input. A novel computer-learning technique called Anatomical Intelligence in ultrasound (AIUS) semiautomatically tracks the annulus and leaflet anatomy for parametric analysis...
October 2016: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/27541972/corneal-sublayers-thickness-in-patients-with-mitral-valve-prolapse
#20
Necati Duru, Oğuz Erman Haşhaş, Emre Göktaş, Zeynep Duru, Hasan Basri Arifoğlu, Döndü Melek Ulusoy, Arzu Seyhan Karatepe Haşhaş, Mustafa Ataş
OBJECTIVES: The aim of this study was to compare the thickness of each corneal sublayer in patients with mitral valve prolapse (MVP) and healthy individuals. METHODS: A total of 38 eyes from 38 patients with MVP and 34 eyes from 34 age- and sex-matched healthy individuals were included in this study. The thickness of the corneal epithelium, Bowman layer, stroma, and Descemet membrane-endothelium complex were measured on the central cornea (i.e., corneal apex) and both the inferior and superior halves of the cornea with anterior segment module of spectral domain optical coherence tomography...
July 12, 2016: Eye & Contact Lens
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