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https://www.readbyqxmd.com/read/27913211/sgrasp-a-graph-based-method-for-the-derivation-of-subject-specific-functional-parcellations-of-the-brain
#1
N Honnorat, T D Satterthwaite, R E Gur, R C Gur, C Davatzikos
BACKGROUND: Resting-state fMRI (rs-fMRI) has emerged as a prominent tool for the study of functional connectivity. The identification of the regions associated with the different brain functions has received significant interest. However, most of the studies conducted so far have focused on the definition of a common set of regions, valid for an entire population. The variation of the functional regions within a population has rarely been accounted for. New Method: In this paper, we propose sGraSP, a graph-based approach for the derivation of subject-specific functional parcellations...
November 29, 2016: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/27913157/further-evidence-of-alerted-default-network-connectivity-and-association-with-theory-of-mind-ability-in-schizophrenia
#2
Omar Mothersill, Noreen Tangney, Derek W Morris, Hazel McCarthy, Thomas Frodl, Michael Gill, Aiden Corvin, Gary Donohoe
BACKGROUND: Resting-state functional magnetic resonance imaging (rs-fMRI) has repeatedly shown evidence of altered functional connectivity of large-scale networks in schizophrenia. The relationship between these connectivity changes and behaviour (e.g. symptoms, neuropsychological performance) remains unclear. METHODS: Functional connectivity in 27 patients with schizophrenia or schizoaffective disorder, and 25 age and gender matched healthy controls was examined using rs-fMRI...
November 29, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27896962/adaptive-testing-of-snp-brain-functional-connectivity-association-via-a-modular-network-analysis
#3
Chen Gao, Junghi Kim, Wei Pan
Due to its high dimensionality and high noise levels, analysis of a large brain functional network may not be powerful and easy to interpret; instead, decomposition of a large network into smaller subcomponents called modules may be more promising as suggested by some empirical evidence. For example, alteration of brain modularity is observed in patients suffering from various types of brain malfunctions. Although several methods exist for estimating brain functional networks, such as the sample correlation matrix or graphical lasso for a sparse precision matrix, it is still difficult to extract modules from such network estimates...
2016: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/27882297/disrupted-functional-connectivity-affects-resting-state-based-language-lateralization
#4
Alex Teghipco, Ali Hussain, Madalina E Tivarus
Pre-operative assessment of language localization and lateralization is critical to preserving brain function after lesion or epileptogenic tissue resection. Task fMRI (t-fMRI) has been extensively and reliably used to this end, but resting state fMRI (rs-fMRI) is emerging as an alternative pre-operative brain mapping method that is independent of a patient's ability to comply with a task. We sought to evaluate if language lateralization obtained from rs-fMRI can replace standard assessment using t-fMRI. In a group of 43 patients scheduled for pre-operative fMRI brain mapping and 17 healthy controls, we found that existing methods of determining rs-fMRI lateralization by considering interhemispheric and intrahemispheric functional connectivity are inadequate compared to t-fMRI when applied to the language network...
2016: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27881961/functional-connectivity-of-child-and-adolescent-attention-deficit-hyperactivity-disorder-patients-correlation-with-iq
#5
Bo-Yong Park, Jisu Hong, Seung-Hak Lee, Hyunjin Park
Attention deficit hyperactivity disorder (ADHD) is a pervasive neuropsychological disorder that affects both children and adolescents. Child and adolescent ADHD patients exhibit different behavioral symptoms such as hyperactivity and impulsivity, but not much connectivity research exists to help explain these differences. We analyzed openly accessible resting-state functional magnetic resonance imaging (rs-fMRI) data on 112 patients (28 child ADHD, 28 adolescent ADHD, 28 child normal control (NC), and 28 adolescent NC)...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27870395/sex-differences-in-associations-of-arginine-vasopressin-and-oxytocin-with-resting-state-functional-brain-connectivity
#6
Leah H Rubin, Li Yao, Sarah K Keedy, James L Reilly, Jeffrey R Bishop, C Sue Carter, Hossein Pournajafi-Nazarloo, Lauren L Drogos, Carol A Tamminga, Godfrey D Pearlson, Matcheri S Keshavan, Brett A Clementz, Scot K Hill, Wei Liao, Gong-Jun Ji, Su Lui, John A Sweeney
Oxytocin (OT) and arginine vasopressin (AVP) exert robust and sexually dimorphic influences on cognition and emotion. How these hormones regulate relevant functional brain systems is not well understood. OT and AVP serum concentrations were assayed in 60 healthy individuals (36 women). Brain functional networks assessed with resting-state functional magnetic resonance imaging (rs-fMRI) were constructed with graph theory-based approaches that characterize brain networks as connected nodes. Sex differences were demonstrated in rs-fMRI...
January 2, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27867352/aberrant-functional-connectivity-between-the-amygdala-and-the-temporal-pole-in-drug-free-generalized-anxiety-disorder
#7
Wei Li, Huiru Cui, Zhipei Zhu, Li Kong, Qian Guo, Yikang Zhu, Qiang Hu, Lanlan Zhang, Hui Li, Qingwei Li, Jiangling Jiang, Jordan Meyers, Jianqi Li, Jijun Wang, Zhi Yang, Chunbo Li
The amygdala and the dorsolateral prefrontal cortex (DLPFC) play important roles in "emotion dysregulation," which has a profound impact on etiologic research of generalized anxiety disorder (GAD). The present study analyzed both eyes-open and eyes-closed resting state functional MRI (rs-fMRI) of 43 subjects (21 GAD patients with medicine free and 22 matched healthy controls). The amygdala and the DLPFC were defined as regions of interest (ROI) to analyze functional connectivity (FC) in GAD patients compared with healthy controls...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27859960/cognitive-phenotypes-in-parkinson-s-disease-differ-in-terms-of-brain-network-organization-and-connectivity
#8
Renaud Lopes, Christine Delmaire, Luc Defebvre, Anja J Moonen, Annelien A Duits, Paul Hofman, Albert F G Leentjens, Kathy Dujardin
Cognitive deficits are common in Parkinson's disease and we suspect that dysfunctions of connected brain regions can be the source of these deficits. The aim of the present study was to investigate changes in whole-brain intrinsic functional connectivity according to differences in cognitive profiles in Parkinson's disease. 119 participants were enrolled and divided into four groups according to their cognitive phenotypes (determined by a cluster analysis): (i) 31 cognitively intact patients (G1), (ii) 31 patients with only slight mental slowing (G2), (iii) 43 patients with mild to moderate deficits mainly in executive functions (G3), (iv) 14 patients with severe deficits in all cognitive domains (G4-5)...
November 17, 2016: Human Brain Mapping
https://www.readbyqxmd.com/read/27859451/altered-spontaneous-brain-activity-in-cushing-s-disease-a-resting-state-functional-mri-study
#9
Hong Jiang, Na-Ying He, Yu-Hao Sun, Fang-Fang Jian, Liu-Guan Bian, Jian-Kang Shen, Fu-Hua Yan, Si-Jian Pan, Qing-Fang Sun
CONTEXT AND OBJECTIVE: Cushing's disease (CD) provides a unique and naturalist model for studying the influence of hypercortisolism on the human brain and the reversibility of these effects after resolution of the condition. This cross-sectional study used resting state fMRI (rs-fMRI) to investigate the altered spontaneous brain activity in CD patients and the trends for potential reversibility after the resolution of the hypercortisolism. We also aim to determine the relationship of these changes with clinical characteristics and cortisol levels...
November 8, 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/27853427/prediction-of-biological-motion-perception-performance-from-intrinsic-brain-network-regional-efficiency
#10
Zengjian Wang, Delong Zhang, Bishan Liang, Song Chang, Jinghua Pan, Ruiwang Huang, Ming Liu
Biological motion perception (BMP) refers to the ability to perceive the moving form of a human figure from a limited amount of stimuli, such as from a few point lights located on the joints of a moving body. BMP is commonplace and important, but there is great inter-individual variability in this ability. This study used multiple regression model analysis to explore the association between BMP performance and intrinsic brain activity, in order to investigate the neural substrates underlying inter-individual variability of BMP performance...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27848148/disrupted-functional-connectivity-density-in-irritable-bowel-syndrome-patients
#11
Yifei Weng, Rongfeng Qi, Chang Liu, Jun Ke, Qiang Xu, Fangyu Wang, Long Jiang Zhang, Guang Ming Lu
Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder resulting from a dysregulation of the brain-gut axis. However, its exact neural substrate still remains unclear. This study investigated the changes of intrinsic whole brain functional connectivity pattern in IBS using functional connectivity density (FCD). We acquired resting-state functional magnetic resonance imaging (rs-fMRI) data from thirty-two IBS patients and thirty-two healthy controls. Functional connectivity density, a data-driven algorithm, was used to compute the long-range and short-range FCD values for each voxel in the brain of each subject, implying the amount of distant and local functional connections of cortical hubs...
November 15, 2016: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/27843651/relationship-between-the-lhpp-gene-polymorphism-and-resting-state-brain-activity-in-major-depressive-disorder
#12
Lingling Cui, Xiaohong Gong, Yanqing Tang, Lingtao Kong, Miao Chang, Haiyang Geng, Ke Xu, Fei Wang
A single-nucleotide polymorphism at the LHPP gene (rs35936514) has been reported in genome-wide association studies to be associated with major depressive disorder (MDD). However, the neural system effects of rs35936514 that mediate the association are unknown. The present work explores whether the LHPP rs35936514 polymorphism moderates brain regional activity in MDD. A total of 160 subjects were studied: a CC group homozygous for the C allele (23 individuals with MDD and 57 controls) and a T-carrier group carrying the high risk T allele (CT/TT genotypes; 22 MDD and 58 controls)...
2016: Neural Plasticity
https://www.readbyqxmd.com/read/27826107/increased-functional-connectivity-one-week-after-motor-learning-and-tdcs-in-stroke-patients
#13
Stéphanie Lefebvre, Laurence Dricot, Patrice Laloux, Philippe Desfontaines, Frédéric Evrard, André Peeters, Jacques Jamart, Yves Vandermeeren
Recent studies using resting-state functional magnetic resonance imaging (rs-fMRI) demonstrated that changes in functional connectivity (FC) after stroke correlate with recovery. The aim of this study was to explore whether combining motor learning to dual transcranial direct current stimulation (dual-tDCS, applied over both primary motor cortices (M1)) modulated FC in stroke patients. Twenty-two chronic hemiparetic stroke patients participated in a baseline rs-fMRI session. One week later, dual-tDCS/sham was applied during motor skill learning (intervention session); one week later, the retention session started with the acquisition of a run of rs-fMRI imaging...
November 5, 2016: Neuroscience
https://www.readbyqxmd.com/read/27812505/prediction-of-long-term-memory-scores-in-mci-based-on-resting-state-fmri
#14
Djalel-Eddine Meskaldji, Maria Giulia Preti, Thomas Aw Bolton, Marie-Louise Montandon, Cristelle Rodriguez, Stephan Morgenthaler, Panteleimon Giannakopoulos, Sven Haller, Dimitri Van De Ville
Resting-state functional MRI (rs-fMRI) opens a window on large-scale organization of brain function. However, establishing relationships between resting-state brain activity and cognitive or clinical scores is still a difficult task, in particular in terms of prediction as would be meaningful for clinical applications such as early diagnosis of Alzheimer's disease. In this work, we employed partial least square regression under cross-validation scheme to predict episodic memory performance from functional connectivity (FC) patterns in a set of fifty-five MCI subjects for whom rs-fMRI acquisition and neuropsychological evaluation was carried out...
2016: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27803653/probing-intrinsic-resting-state-networks-in-the-infant-rat-brain
#15
Dusica Bajic, Michael M Craig, David Borsook, Lino Becerra
Resting-state functional magnetic resonance imaging (rs-fMRI) measures spontaneous fluctuations in blood oxygenation level-dependent (BOLD) signal in the absence of external stimuli. It has become a powerful tool for mapping large-scale brain networks in humans and animal models. Several rs-fMRI studies have been conducted in anesthetized and awake adult rats, reporting consistent patterns of brain activity at the systems level. However, the evolution to adult patterns of resting-state activity has not yet been evaluated and quantified in the developing rat brain...
2016: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/27788143/brain-connectivity-changes-in-autosomal-recessive-parkinson-disease-a-model-for-the-sporadic-form
#16
Elena Makovac, Mara Cercignani, Laura Serra, Mario Torso, Barbara Spanò, Simona Petrucci, Lucia Ricciardi, Monia Ginevrino, Carlo Caltagirone, Anna Rita Bentivoglio, Enza Maria Valente, Marco Bozzali
Biallelic genetic mutations in the Park2 and PINK1 genes are frequent causes of autosomal recessive PD. Carriers of single heterozygous mutations may manifest subtle signs of disease, thus providing a unique model of preclinical PD. One emerging hypothesis suggests that non-motor symptom of PD, such as cognitive impairment may be due to a distributed functional disruption of various neuronal circuits. Using resting-state functional MRI (RS-fMRI), we tested the hypothesis that abnormal connectivity within and between brain networks may account for the patients' cognitive status...
2016: PloS One
https://www.readbyqxmd.com/read/27776388/the-effects-of-equine-assisted-activities-and-therapy-on-resting-state-brain-function-in-attention-deficit-hyperactivity-disorder-a-pilot-study
#17
Jae Hyun Yoo, Yunhye Oh, Byongsu Jang, Jihye Song, Jiwon Kim, Seonwoo Kim, Jiyoung Lee, Hye-Yeon Shin, Jeong-Yi Kwon, Yun-Hee Kim, Bumseok Jeong, Yoo-Sook Joung
Objective: Equine-assisted activities and therapy (EAA/T) have been used as adjunct treatment options for physical and psychosocial rehabilitation. However, the therapeutic effects on resting-state brain function have not yet been studied. The aim of this study is to investigate the effects of EAA/T on participants with attention-deficit/hyperactivity disorder (ADHD) by comparing resting-state functional magnetic resonance imaging (rs-fMRI) signals and their clinical correlates. Methods: Ten participants with ADHD participated in a 12-week EAA/T program without any medication...
November 30, 2016: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27774631/resting-state-functional-mri-as-a-tool-for-evaluating-brain-hemodynamic-responsiveness-to-external-stimuli-in-rats
#18
Jaakko Paasonen, Raimo A Salo, Joanna K Huttunen, Olli Gröhn
PURPOSE: Anesthesia is a major confounding factor in functional MRI (fMRI) experiments attributed to its effects on brain function. Recent evidence suggests that parameters obtained with resting-state fMRI (rs-fMRI) are coupled with anesthetic depth. Therefore, we investigated whether parameters obtained with rs-fMRI, such as functional connectivity (FC), are also directly related to blood-oxygen-level-dependent (BOLD) responses. METHODS: A simple rs-fMRI protocol was implemented in a pharmacological fMRI study to evaluate the coupling between hemodynamic responses and FC under five anesthetics (α-chloralose, isoflurane, medetomidine, thiobutabarbital, and urethane)...
October 23, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27771857/brain-alterations-in-low-frequency-fluctuations-across-multiple-bands-in-obsessive-compulsive-disorder
#19
Mònica Giménez, Andrés Guinea-Izquierdo, Victoria Villalta-Gil, Ignacio Martínez-Zalacaín, Cinto Segalàs, Marta Subirà, Eva Real, Jesús Pujol, Ben J Harrison, Josep Maria Haro, Joao R Sato, Marcelo Q Hoexter, Narcís Cardoner, Pino Alonso, José Manuel Menchón, Carles Soriano-Mas
The extent of functional abnormalities in frontal-subcortical circuits in obsessive-compulsive disorder (OCD) is still unclear. Although neuroimaging studies, in general, and resting-state functional Magnetic Resonance Imaging (rs-fMRI), in particular, have provided relevant information regarding such alterations, rs-fMRI studies have been typically limited to the analysis of between-region functional connectivity alterations at low-frequency signal fluctuations (i.e., <0.08 Hz). Conversely, the local attributes of Blood Oxygen Level Dependent (BOLD) signal across different frequency bands have been seldom studied, although they may provide valuable information...
October 22, 2016: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/27760995/differential-effects-of-l-tryptophan-and-l-leucine-administration-on-brain-resting-state-functional-networks-and-plasma-hormone-levels
#20
Davide Zanchi, Anne Christin Meyer-Gerspach, Claudia Suenderhauf, Katharina Janach, Carel W le Roux, Sven Haller, Jürgen Drewe, Christoph Beglinger, Bettina K Wölnerhanssen, Stefan Borgwardt
Depending on their protein content, single meals can rapidly influence the uptake of amino acids into the brain and thereby modify brain functions. The current study investigates the effects of two different amino acids on the human gut-brain system, using a multimodal approach, integrating physiological and neuroimaging data. In a randomized, placebo-controlled trial, L-tryptophan, L-leucine, glucose and water were administered directly into the gut of 20 healthy subjects. Functional MRI (fMRI) in a resting state paradigm (RS), combined with the assessment of insulin and glucose blood concentration, was performed before and after treatment...
October 20, 2016: Scientific Reports
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