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https://www.readbyqxmd.com/read/28424611/modafinil-induced-changes-in-functional-connectivity-in-the-cortex-and-cerebellum-of-healthy-elderly-subjects
#1
Miriam Punzi, Tommaso Gili, Laura Petrosini, Carlo Caltagirone, Gianfranco Spalletta, Stefano L Sensi
In the past few years, cognitive enhancing drugs (CEDs) have gained growing interest and the focus of investigations aimed at exploring their use to potentiate the cognitive performances of healthy individuals. Most of this exploratory CED-related research has been performed on young adults. However, CEDs may also help to maintain optimal brain functioning or compensate for subtle and or subclinical deficits associated with brain aging or early-stage dementia. In this study, we assessed effects on resting state brain activity in a group of healthy elderly subjects undergoing acute administration of modafinil, a wakefulness-promoting agent...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28420981/age-related-difference-in-functional-brain-connectivity-of-mastication
#2
Chia-Shu Lin, Ching-Yi Wu, Shih-Yun Wu, Hsiao-Han Lin, Dong-Hui Cheng, Wen-Liang Lo
The age-related decline in motor function is associated with changes in intrinsic brain signatures. Here, we investigated the functional connectivity (FC) associated with masticatory performance, a clinical index evaluating general masticatory function. Twenty-six older adults (OA) and 26 younger (YA) healthy adults were recruited and assessed using the masticatory performance index (MPI) and resting-state functional magnetic resonance imaging (rs-fMRI). We analyzed the rs-fMRI FC network related to mastication, which was constructed based on 12 bilateral mastication-related brain regions according to the literature...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28420972/multi-modal-multi-measure-and-multi-class-discrimination-of-adhd-with-hierarchical-feature-extraction-and-extreme-learning-machine-using-structural-and-functional-brain-mri
#3
Muhammad Naveed Iqbal Qureshi, Jooyoung Oh, Beomjun Min, Hang Joon Jo, Boreom Lee
Structural and functional MRI unveil many hidden properties of the human brain. We performed this multi-class classification study on selected subjects from the publically available attention deficit hyperactivity disorder ADHD-200 dataset of patients and healthy children. The dataset has three groups, namely, ADHD inattentive, ADHD combined, and typically developing. We calculated the global averaged functional connectivity maps across the whole cortex to extract anatomical atlas parcellation based features from the resting-state fMRI (rs-fMRI) data and cortical parcellation based features from the structural MRI (sMRI) data...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28408865/tau-pathology-distribution-in-alzheimer-s-disease-corresponds-differentially-to-cognition-relevant-functional-brain-networks
#4
Oskar Hansson, Michel J Grothe, Tor Olof Strandberg, Tomas Ohlsson, Douglas Hägerström, Jonas Jögi, Ruben Smith, Michael Schöll
Neuropathological studies have shown that the typical neurofibrillary pathology of hyperphosphorylated tau protein in Alzheimer's disease (AD) preferentially affects specific brain regions whereas others remain relatively spared. It has been suggested that the distinct regional distribution profile of tau pathology in AD may be a consequence of the intrinsic network structure of the human brain. The spatially distributed brain regions that are most affected by the spread of tau pathology may hence reflect an interconnected neuronal system...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28406312/repeatability-of-graph-theoretical-metrics-derived-from-resting-state-functional-networks-in-pediatric-epilepsy-patients
#5
Michael J Paldino, Zili D Chu, Mary L Chapieski, Farahnaz Golriz, Wei Zhang
OBJECTIVES: To measure the repeatability of metrics that quantify brain network architecture derived from resting-state fMRI (rs-fMRI) in a cohort of pediatric epilepsy patients. METHODS: We identified patients with: 1. epilepsy; 2. brain MRI at 3 Tesla; 3. two identical rs-fMRI acquisitions performed on the same day. Undirected, weighted networks were constructed based on the resting state time series using a range of processing parameters including parcellation size and graph threshold...
April 13, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28404808/use-of-rs-fmri-in-fabry-disease-do-we-need-it
#6
Antonio Siniscalchi
No abstract text is available yet for this article.
April 12, 2017: Neurology
https://www.readbyqxmd.com/read/28404798/alterations-of-functional-connectivity-of-the-motor-cortex-in-fabry-disease-an-rs-fmri-study
#7
Sirio Cocozza, Antonio Pisani, Gaia Olivo, Francesco Saccà, Lorenzo Ugga, Eleonora Riccio, Silvia Migliaccio, Vincenzo Brescia Morra, Arturo Brunetti, Mario Quarantelli, Enrico Tedeschi
OBJECTIVE: To evaluate the presence of functional connectivity (FC) alterations of the motor circuits in patients with Fabry disease (FD) and their possible correlation with clinical variables with a resting-state (RS) fMRI analysis. METHODS: In our cross-sectional study, 32 patients with FD with genetically confirmed classic diagnosis of FD (12 men, mean age 43.3 ± 12.2 years) were enrolled along with 35 healthy controls (HCs) of comparable age and sex (14 men, mean age 42...
April 12, 2017: Neurology
https://www.readbyqxmd.com/read/28400737/reduced-resting-state-functional-connectivity-in-current-and-recovered-restrictive-anorexia-nervosa
#8
Jessica Clare Scaife, Lauren Rose Godier, Nicola Filippini, Catherine J Harmer, Rebecca J Park
Functional connectivity studies based on resting-state functional magnetic resonance imaging (rs-fMRI) have shown alterations in brain networks associated with self-referential processing, cognitive control, and somatosensory processing in anorexia nervosa (AN). This study aimed to further investigate the functional connectivity of resting-state networks (RSNs) in homogenous subsamples of individuals with restrictive AN (current and recovered) and the relationship this has with core eating disorder psychopathology...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28393012/the-effect-of-repetitive-subconcussive-collisions-on-brain-integrity-in-collegiate-football-players-over-a-single-football-season-a-multi-modal-neuroimaging-study
#9
Semyon M Slobounov, Alexa Walter, Hans C Breiter, David C Zhu, Xiaoxiao Bai, Tim Bream, Peter Seidenberg, Xianglun Mao, Brian Johnson, Thomas M Talavage
The cumulative effect of repetitive subconcussive collisions on the structural and functional integrity of the brain remains largely unknown. Athletes in collision sports, like football, experience a large number of impacts across a single season of play. The majority of these impacts, however, are generally overlooked, and their long-term consequences remain poorly understood. This study sought to examine the effects of repetitive collisions across a single competitive season in NCAA Football Bowl Subdivision athletes using advanced neuroimaging approaches...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28392488/improved-7-tesla-resting-state-fmri-connectivity-measurements-by-cluster-based-modeling-of-respiratory-volume-and-heart-rate-effects
#10
Joana Pinto, Sandro Nunes, Marta Bianciardi, Afonso Dias, L Miguel Silveira, Lawrence L Wald, Patrícia Figueiredo
Several strategies have been proposed to model and remove physiological noise from resting-state fMRI (rs-fMRI) data, particularly at ultrahigh fields (7 T), including contributions from respiratory volume (RV) and heart rate (HR) signal fluctuations. Recent studies suggest that these contributions are highly variable across subjects and that physiological noise correction may thus benefit from optimization at the subject or even voxel level. Here, we systematically investigated the impact of the degree of spatial specificity (group, subject, newly proposed cluster, and voxel levels) on the optimization of RV and HR models...
April 6, 2017: NeuroImage
https://www.readbyqxmd.com/read/28385876/concurrent-tacs-fmri-reveals-causal-influence-of-power-synchronized-neural-activity-on-resting-state-fmri-connectivity
#11
Marc Bächinger, Valerio Zerbi, Marius Moisa, Rafael Polania, Quanying Liu, Dante Mantini, Christian Ruff, Nicole Wenderoth
Resting state fMRI (rs-fMRI) is commonly used to study the brain's intrinsic neural coupling, which reveals specific spatiotemporal patterns in the form of resting state networks (RSN). It has been hypothesized that slow rs-fMRI oscillations (<0.1 Hz) are driven by underlying electrophysiological rhythms that typically occur at much faster timescales (>5 Hz); however, causal evidence for this relationship is currently lacking. Here we measured rs-fMRI in humans while applying transcranial alternating current stimulation (tACS) to entrain brain rhythms in left and right sensorimotor cortices...
April 6, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28377688/latent-and-abnormal-functional-connectivity-circuits-in-autism-spectrum-disorder
#12
Shuo Chen, Yishi Xing, Jian Kang
Autism spectrum disorder (ASD) is associated with disrupted brain networks. Neuroimaging techniques provide noninvasive methods of investigating abnormal connectivity patterns in ASD. In the present study, we compare functional connectivity networks in people with ASD with those in typical controls, using neuroimaging data from the Autism Brain Imaging Data Exchange (ABIDE) project. Specifically, we focus on the characteristics of intrinsic functional connectivity based on data collected by resting-state functional magnetic resonance imaging (rs-fMRI)...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28352072/functional-insights-into-aberrant-brain-responses-and-integration-in-patients-with-lifelong-premature-ejaculation
#13
Bing Zhang, Jiaming Lu, Jiadong Xia, Fangfang Wang, Weiping Li, Fei Chen, Youfeng Han, Yun Chen, Bin Zhu, Zhao Qing, Xin Zhang, Yutian Dai
Even though lifelong premature ejaculation (PE) is highly prevalent, few studies have investigated the neural mechanisms underlying PE. The extent and pattern of brain activation can be determined through a version of functional magnetic resonance imaging (fMRI) with erotic picture stimuli (task fMRI) and a resting-state fMRI (rs fMRI). We showed that the brain activity in the left inferior frontal gyrus and left insula was decreased both during the task and in the resting state, while there was higher activation in the right middle temporal gyrus during the task...
March 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28337552/clinical-utility-of-resting-state-functional-connectivity-magnetic-resonance-imaging-for-mood-and-cognitive-disorders
#14
REVIEW
T Takamura, T Hanakawa
Although functional magnetic resonance imaging (fMRI) has long been used to assess task-related brain activity in neuropsychiatric disorders, it has not yet become a widely available clinical tool. Resting-state fMRI (rs-fMRI) has been the subject of recent attention in the fields of basic and clinical neuroimaging research. This method enables investigation of the functional organization of the brain and alterations of resting-state networks (RSNs) in patients with neuropsychiatric disorders. Rs-fMRI does not require participants to perform a demanding task, in contrast to task fMRI, which often requires participants to follow complex instructions...
March 23, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28333946/structural-and-functional-connectional-fingerprints-in-mild-cognitive-impairment-and-alzheimer-s-disease-patients
#15
Seong-Jin Son, Jonghoon Kim, Hyunjin Park
Regional volume atrophy and functional degeneration are key imaging hallmarks of Alzheimer's disease (AD) in structural and functional magnetic resonance imaging (MRI), respectively. We jointly explored regional volume atrophy and functional connectivity to better characterize neuroimaging data of AD and mild cognitive impairment (MCI). All data were obtained from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database. We compared regional volume atrophy and functional connectivity in 10 subcortical regions using structural MRI and resting-state functional MRI (rs-fMRI)...
2017: PloS One
https://www.readbyqxmd.com/read/28328579/resting-state-functional-connectivity-predicts-longitudinal-pain-symptom-change-in-urologic-chronic-pelvic-pain-syndrome-a-mapp-network-study
#16
Jason J Kutch, Jennifer S Labus, Richard E Harris, Katherine T Martucci, Melissa A Farmer, Sonja Fenske, Connor Fling, Eric Ichesco, Scott Peltier, Bogdan Petre, Wensheng Guo, Xiaoling Hou, Alisa J Stephens, Chris Mullins, Daniel J Clauw, Sean C Mackey, A Vania Apkarian, J Richard Landis, Emeran A Mayer
Chronic pain symptoms often change over time, even in individuals who have had symptoms for years. Studying biological factors that predict trends in symptom change in chronic pain may uncover novel pathophysiological mechanisms and potential therapeutic targets. In this study, we investigated whether brain functional connectivity measures obtained from resting-state functional MRI (rs-fMRI) at baseline can predict longitudinal symptom change (3, 6, and 12 months post-scan) in urologic chronic pelvic pain syndrome (UCPPS)...
March 17, 2017: Pain
https://www.readbyqxmd.com/read/28321594/disrupted-functional-connectivity-of-periaqueductal-gray-subregions-in-episodic-migraine
#17
Zhiye Chen, Xiaoyan Chen, Mengqi Liu, Shuangfeng Liu, Lin Ma, Shengyuan Yu
BACKGROUND: The periaqueductal gray (PAG) dysfunction was recognized in migraine, and the altered dysfunction of PAG subregions were not totally detected up to now. The aim of this study is to investigate the altered functional connectivity of PAG subregions in EM patients. METHODS: The brain structural images and resting state functional MR imaging (rs-fMRI) data were obtained from 18 normal controls (NC) and 18 EM patients on 3.0 T MR system. Seven subregions of PAG were classified as bilateral ventrolateral PAG (vlPAG), lateral PAG (lPAG), dorsolateral PAG (dlPAG) and dorsomedial PAG (dmPAG)...
December 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28318985/functional-disconnection-of-thalamic-and-cerebellar-dentate-nucleus-networks-in-progressive-supranuclear-palsy-and-corticobasal-syndrome
#18
Neeraj Upadhyay, Antonio Suppa, Maria Cristina Piattella, Costanza Giannì, Matteo Bologna, Flavio Di Stasio, Nikolaos Petsas, Francesca Tona, Giovanni Fabbrini, Alfredo Berardelli, Patrizia Pantano
AIM: To assess functional rearrangement following neurodegeneration in the thalamus and dentate nucleus in patients with progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS). METHODS: We recruited 19 patients with PSP, 11 with CBS and 14 healthy subjects. All the subjects underwent resting-state (rs) fMRI using a 3T system. Whole brain functional connectivity of the thalamus and dentate nucleus were calculated by means of a seed-based approach with FEAT script in FSL toolbox...
March 15, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28315459/dynamic-reorganization-of-intrinsic-functional-networks-in-the-mouse-brain
#19
Joanes Grandjean, Maria Giulia Preti, Thomas A W Bolton, Michaela Buerge, Erich Seifritz, Christopher R Pryce, Dimitri Van De Ville, Markus Rudin
Functional connectivity (FC) derived from resting-state functional magnetic resonance imaging (rs-fMRI) allows for the integrative study of neuronal processes at a macroscopic level. The majority of studies to date have assumed stationary interactions between brain regions, without considering the dynamic aspects of network organization. Only recently has the latter received increased attention, predominantly in human studies. Applying dynamic FC (dFC) analysis to mice is attractive given the relative simplicity of the mouse brain and the possibility to explore mechanisms underlying network dynamics using pharmacological, environmental or genetic interventions...
March 14, 2017: NeuroImage
https://www.readbyqxmd.com/read/28295805/resting-state-functional-connectivity-and-cognitive-dysfunction-correlations-in-spinocerebelellar-ataxia-type-6-sca6
#20
Licia Pereira, Raag D Airan, Ann Fishman, Jay J Pillai, Kalyani Kansal, Chiadi U Onyike, Jerry L Prince, Sarah H Ying, Haris I Sair
OBJECTIVE: The aim of this study is to evaluate the correlation between resting state functional MRI (RS-fMRI) activity and motor and cognitive impairment in spinocerebellar ataxia type 6 (SCA6). METHODS: Twelve patients with genetically confirmed SCA6 and 14 age matched healthy controls were imaged with RS-fMRI. Whole brain gray matter was automatically parcellated into 1000 regions of interest (ROIs). For each ROI, the first eigenvariate of voxel time courses was extracted...
March 15, 2017: Human Brain Mapping
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