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https://www.readbyqxmd.com/read/29681927/altered-structural-and-functional-connectivity-of-juvenile-myoclonic-epilepsy-an-fmri-study
#1
Chengqing Zhong, Rong Liu, Cheng Luo, Sisi Jiang, Li Dong, Rui Peng, Fuqiang Guo, Pu Wang
The aim of this study was to investigate the structural and functional connectivity (FC) of juvenile myoclonic epilepsy (JME) using resting state functional magnetic resonance imaging (rs-fMRI). High-resolution T1-weighted magnetic resonance imaging (MRI) and rs-fMRI data were collected in 25 patients with JME and in 24 control subjects. A FC analysis was subsequently performed, with seeding at the regions that demonstrated between-group differences in gray matter volume (GMV). Then, the observed structural and FCs were associated with the clinical manifestations...
2018: Neural Plasticity
https://www.readbyqxmd.com/read/29680421/mapping-the-changed-hubs-and-corresponding-functional-connectivity-in-idiopathic-restless-legs-syndrome
#2
Chunyan Liu, Jiaojian Wang, Yue Hou, Zhigang Qi, Li Wang, Shuqin Zhan, Rong Wang, Yuping Wang
OBJECTIVE: The hubs of the brain network play a key role in integrating and transferring information between different functional modules. However, whether the changed pattern in functional network hubs contributes to the onset of leg discomfort symptoms in restless legs syndrome (RLS) patients remains unclear. Using resting-state functional magnetic resonance imaging (rs-fMRI) and graph theory methods, we investigated whether alterations of hubs can be detected in RLS. METHODS: First, we constructed the whole-brain voxelwise functional connectivity and calculated a functional connectivity strength (FCS) map in each of 16 drug-naive idiopathic RLS patients and 26 gender- and age-matched healthy control (HC) subjects...
May 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29679735/age-dependent-effects-of-brain-stimulation-on-network-centrality
#3
Daria Antonenko, Till Nierhaus, Marcus Meinzer, Kristin Prehn, Axel Thielscher, Bernd Ittermann, Agnes Flöel
Functional magnetic resonance imaging (fMRI) studies have suggested that advanced age may mediate the effects of transcranial direct current stimulation (tDCS) on brain function. However, studies directly comparing neural tDCS effects between young and older adults are scarce and limited to task-related imaging paradigms. Resting-state (rs-) fMRI, that is independent of age-related differences in performance, is well suited to investigate age-associated differential neural tDCS effects. Three "online" tDCS conditions (anodal, cathodal, sham) were compared in a cross-over, within-subject design, in 30 young and 30 older adults...
April 18, 2018: NeuroImage
https://www.readbyqxmd.com/read/29677346/reduced-functional-and-anatomic-interhemispheric-homotopic-connectivity-in-primary-open-angle-glaucoma-a-combined-resting-state-fmri-and-dti-study
#4
Qian Wang, Weiwei Chen, Huaizhou Wang, Xun Zhang, Xiaoxia Qu, Ying Wang, Ting Li, Ningli Wang, Junfang Xian
Purpose: To investigate if abnormal interhemispheric homotopic functional connectivity were accompanied by corresponding anatomic connectivity changes in primary open-angle glaucoma (POAG) patients, and to relate connectivity changes with retinal nerve fiber layer (RNFL) thickness and ganglion cell complex (GCC) thickness. Methods: Resting-state functional magnetic resonance imaging (rs-fMRI) and diffusion tensor imaging (DTI) were performed in 16 POAG patients and 19 healthy controls...
April 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29671156/alteration-and-role-of-interhemispheric-and-intrahemispheric-connectivity-in-motor-network-after-stroke
#5
Jungsoo Lee, Eunhee Park, Ahee Lee, Won Hyuk Chang, Dae-Shik Kim, Yun-Hee Kim
This study investigated local and global changes in the motor network using longitudinal resting-state functional magnetic resonance imaging (rs-fMRI). Motor impairment was measured in 81 stroke patients using Fugl-Meyer assessment on the same day as rs-fMRI acquisition at both 2 weeks and 3 months post-stroke. The relationships between network measures and motor function scores were assessed. With regard to local connectivity, interhemispheric connectivity was noticeably altered at each time point. Interhemispheric connectivity was also related to residual motor function and improvement in motor function...
April 18, 2018: Brain Topography
https://www.readbyqxmd.com/read/29665699/characterizing-signals-within-lesions-and-mapping-brain-network-connectivity-after-traumatic-axonal-injury-a-7-tesla-resting-state-fmri-study
#6
Seul Lee, Jonathan R Polimeni, Collin M Price, Brian L Edlow, Jennifer A McNab
Resting-state functional magnetic resonance imaging (RS-FMRI) has been widely used to map brain functional connectivity, but it is unclear how to probe connectivity within and around lesions. Here we characterize RS-FMRI signal time-course properties and evaluate different seed placements within and around hemorrhagic traumatic axonal injury lesions. RS-FMRI was performed on a 7 Tesla scanner in a patient who recovered consciousness after traumatic coma and in three healthy controls. Eleven lesions in the patient were characterized in terms of: 1) temporal signal-to-noise ratio (tSNR); 2) physiological noise, through comparison of noise regressors derived from the white matter (WM), cerebrospinal fluid (CSF) and gray matter (GM); and 3) seed-based functional connectivity...
April 18, 2018: Brain Connectivity
https://www.readbyqxmd.com/read/29662444/distinctive-correspondence-between-separable-visual-attention-functions-and-intrinsic-brain-networks
#7
Adriana L Ruiz-Rizzo, Julia Neitzel, Hermann J Müller, Christian Sorg, Kathrin Finke
Separable visual attention functions are assumed to rely on distinct but interacting neural mechanisms. Bundesen's "theory of visual attention" (TVA) allows the mathematical estimation of independent parameters that characterize individuals' visual attentional capacity (i.e., visual processing speed and visual short-term memory storage capacity) and selectivity functions (i.e., top-down control and spatial laterality). However, it is unclear whether these parameters distinctively map onto different brain networks obtained from intrinsic functional connectivity, which organizes slowly fluctuating ongoing brain activity...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29656446/hemodynamic-response-function-hrf-variability-confounds-resting-state-fmri-functional-connectivity
#8
D Rangaprakash, Guo-Rong Wu, Daniele Marinazzo, Xiaoping Hu, Gopikrishna Deshpande
PURPOSE: fMRI is the convolution of the hemodynamic response function (HRF) and unmeasured neural activity. HRF variability (HRFv) across the brain could, in principle, alter functional connectivity (FC) estimates from resting-state fMRI (rs-fMRI). Given that HRFv is driven by both neural and non-neural factors, it is problematic when it confounds FC. However, this aspect has remained largely unexplored even though FC studies have grown exponentially. We hypothesized that HRFv confounds FC estimates in the brain's default-mode-network...
April 15, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29655489/the-cochleural-alternating-acoustic-beam-therapy-caabt-a-pre-clinical-trial
#9
Chunli Liu, Han Lv, Tao Jiang, Jing Xie, Lu He, Guopeng Wang, Jiao Liu, Zhenchang Wang, Shusheng Gong
PURPOSE: We intend to assess the effectiveness of a novel tinnitus treatment therapy, the Cochleural Alternating Acoustic Beam Therapy (CAABT) using the psychoacoustic measures, the questionnaires and rs-fMRI. MATERIALS AND METHODS: In this study, we enrolled 11 older than 18 years old Chinese patients with normal hearing who had unilateral, chronic (longer than 6 months), sensorineural tinnitus, of frequencies between 125-8000 Hz, and an average loudness of 31 dB...
April 3, 2018: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29650266/increased-sensorimotor-network-connectivity-associated-with-clozapine-eligibility-in-people-with-schizophrenia
#10
Carolyn Beth McNabb, Frederick Sundram, Ian Soosay, Robert R Kydd, Bruce Roy Russell
Schizophrenia is a heterogeneous disorder that exhibits variable responsiveness to treatment between individuals. Here we conducted a resting-state functional magnetic resonance imaging (rs-fMRI) study to determine whether resistance to first-line antipsychotics is reflected in resting-state connectivity. rs-fMRI data were collected from 15 people who had failed to respond to first-line antipsychotics (clozapine-eligible) and 10 first-line treatment responders (FLR). Image pre-processing and analysis were performed using FMRIB's software library (FSL)...
March 6, 2018: Psychiatry research. Neuroimaging
https://www.readbyqxmd.com/read/29643827/do-future-limitation-perspective-in-cancer-patients-predict-fear-of-cancer-recurrence-mental-distress-and-the-ventromedial-prefrontal-cortex-activity
#11
Jia Zhou, Pan Feng, Xiaofei Lu, Xingping Han, Yanli Yang, Jingjing Song, Guangyu Jiang, Yong Zheng
Life-threatening diseases (e.g., cancer) affect people's future time perspective (FTP) and affect their mental health. When one's lifetime is perceived as running out, the individual possesses a future limitation perspective (FLP), which is one of factors in FTP. In this study, we explored the structural relationship between FLP, fear of cancer recurrence (FCR), mental health status (MHS), and brain activity in patients with cancer. Cancer patients were divided into two groups using the FTP scale and Feelings About Life Scale: a strong FLP group (S-FLP) and a weak FLP group (W-FLP)...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29628269/cerebellar-abnormalities-in-first-episode-drug-naive-schizophrenia-at-rest
#12
Wenbin Guo, Fengyu Zhang, Feng Liu, Jindong Chen, Renrong Wu, Danny Q Chen, Zhikun Zhang, Jinguo Zhai, Jingping Zhao
The cerebellum plays a crucial role in higher cortical functions through a cerebellar-cerebral circuit. However, the specific mechanisms through which the cerebellum contributes to the neurobiology of schizophrenia remain unclear. Forty-nine first-episode, drug-naive patients with schizophrenia and 50 healthy controls underwent structural and resting-state functional magnetic resonance imaging (rs-fMRI). The MRI data were analyzed using voxel-based morphometry, amplitude of low-frequency fluctuations (ALFF), cerebellum homogeneity (CH), and seed-based functional connectivity (FC)...
March 29, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29618564/postnatal-zika-virus-infection-is-associated-with-persistent-abnormalities-in-brain-structure-function-and-behavior-in-infant-macaques
#13
Maud Mavigner, Jessica Raper, Zsofia Kovacs-Balint, Sanjeev Gumber, Justin T O'Neal, Siddhartha K Bhaumik, Xiaodong Zhang, Jakob Habib, Cameron Mattingly, Circe E McDonald, Victoria Avanzato, Mark W Burke, Diogo M Magnani, Varian K Bailey, David I Watkins, Thomas H Vanderford, Damien Fair, Eric Earl, Eric Feczko, Martin Styner, Sherrie M Jean, Joyce K Cohen, Guido Silvestri, R Paul Johnson, David H O'Connor, Jens Wrammert, Mehul S Suthar, Mar M Sanchez, Maria C Alvarado, Ann Chahroudi
The Zika virus (ZIKV) epidemic is associated with fetal brain lesions and other serious birth defects classified as congenital ZIKV syndrome. Postnatal ZIKV infection in infants and children has been reported; however, data on brain anatomy, function, and behavioral outcomes following infection are absent. We show that postnatal ZIKV infection of infant rhesus macaques (RMs) results in persistent structural and functional alterations of the central nervous system compared to age-matched controls. We demonstrate ZIKV lymphoid tropism and neurotropism in infant RMs and histopathologic abnormalities in the peripheral and central nervous systems including inflammatory infiltrates, astrogliosis, and Wallerian degeneration...
April 4, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/29615873/alterations-of-white-matter-integrity-and-hippocampal-functional-connectivity-in-type-2-diabetes-without-mild-cognitive-impairment
#14
Qian Sun, Guan-Qun Chen, Xi-Bin Wang, Ying Yu, Yu-Chuan Hu, Lin-Feng Yan, Xin Zhang, Yang Yang, Jin Zhang, Bin Liu, Cong-Cong Wang, Yi Ma, Wen Wang, Ying Han, Guang-Bin Cui
Aims : To investigate the white matter (WM) integrity and hippocampal functional connectivity (FC) in type 2 diabetes mellitus (T2DM) patients without mild cognitive impairment (MCI) by using diffusion tensor imaging (DTI) and resting-state functional magnetic resonance imaging (rs-fMRI), respectively. Methods : Twelve T2DM patients without MCI and 24 age, sex and education matched healthy controls (HC) were recruited. DTI and rs-fMRI data were subsequently acquired on a 3.0T MR scanner. Tract-based spatial statistics (TBSS) combining region of interests (ROIs) analysis was used to investigate the alterations of DTI metrics (fractional anisotropy (FA), mean diffusivity (MD), λ1 and λ23 ) and FC measurement was performed to calculate hippocampal FC with other brain regions...
2018: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/29615790/multivariate-granger-causality-unveils-directed-parietal-to-prefrontal-cortex-connectivity-during-task-free-mri
#15
Andrea Duggento, Luca Passamonti, Gaetano Valenza, Riccardo Barbieri, Maria Guerrisi, Nicola Toschi
While a large body of research has focused on the study of functional brain "connectivity", few investigators have focused on directionality of brain-brain interactions which, in spite of the mostly bidirectional anatomical substrates, cannot be assumed to be symmetrical. We employ a multivariate Granger Causality-based approach to estimating directed in-network interactions and quantify its advantages using extensive realistic synthetic BOLD data simulations to match Human Connectome Project (HCP) data specification...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29614925/selective-map-following-navigation-deficit-a-new-case-of-developmental-topographical-disorientation
#16
Massimiliano Conson, Filippo Bianchini, Mario Quarantelli, Maddalena Boccia, Sara Salzano, Antonella Di Vita, Cecilia Guariglia
INTRODUCTION: Developmental topographical disorientation (DTD) is a lifelong condition in which affected individuals are selectively impaired in navigating space. Although it seems that DTD is widespread in the population, only a few cases have been studied from both a behavioral and a neuroimaging point of view. Here, we report a new case of DTD, never described previously, of a young woman (C.F.) showing a specific deficit in translating allocentrically coded information into egocentrically guided navigation, in presence of spared ability of constructing such representations...
April 4, 2018: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/29614652/single-subject-classification-of-alzheimer-s-disease-and-behavioral-variant-frontotemporal-dementia-using-anatomical-diffusion-tensor-and-resting-state-functional-magnetic-resonance-imaging
#17
Mark J R J Bouts, Christiane Möller, Anne Hafkemeijer, John C van Swieten, Elise Dopper, Wiesje M van der Flier, Hugo Vrenken, Alle Meije Wink, Yolande A L Pijnenburg, Philip Scheltens, Frederik Barkhof, Tijn M Schouten, Frank de Vos, Rogier A Feis, Jeroen van der Grond, Mark de Rooij, Serge A R B Rombouts
BACKGROUND/OBJECTIVE: Overlapping clinical symptoms often complicate differential diagnosis between patients with Alzheimer's disease (AD) and behavioral variant frontotemporal dementia (bvFTD). Magnetic resonance imaging (MRI) reveals disease specific structural and functional differences that aid in differentiating AD from bvFTD patients. However, the benefit of combining structural and functional connectivity measures to-on a subject-basis-differentiate these dementia-types is not yet known...
January 24, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29611075/presurgical-localization-and-spatial-shift-of-resting-state-networks-in-patients-with-brain-metastases
#18
Ju-Rong Ding, Fangmei Zhu, Bo Hua, Xingzhong Xiong, Yuqiao Wen, Zhongxiang Ding, Paul M Thompson
Brain metastases are the most prevalent cerebral tumors. Resting state networks (RSNs) are involved in multiple perceptual and cognitive functions. Therefore, precisely localizing multiple RSNs may be extremely valuable before surgical resection of metastases, to minimize neurocognitive impairments. Here we aimed to investigate the reliability of independent component analysis (ICA) for localizing multiple RSNs from resting-state functional MRI (rs-fMRI) data in individual patients, and further evaluate lesion-related spatial shifts of the RSNs...
April 2, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29602542/decreased-interhemispheric-homotopic-connectivity-in-parkinson-s-disease-patients-with-freezing-of-gait-a-resting-state-fmri-study
#19
Junyi Li, Yongsheng Yuan, Min Wang, Jiejin Zhang, Li Zhang, Siming Jiang, Xixi Wang, Jian Ding, Kezhong Zhang
INTRODUCTION: Freezing of gait is a common complaint in patients with Parkinson's disease (PD). However, the neural bases of freezing of gait in PD remain uncertain. Existing studies on PD patients with freezing of gait (PD-FOG+) have reported damage of the corpus callosum, the largest commissural bundle of the brain. Thus, in this study we explored homotopic connectivity to investigate FOG-related interehemispheric alterations METHODS: A total of 21 PD-FOG + patients, 33 PD patients without freezing of gait (PD-FOG-), and 24 matched healthy controls were recruited...
March 26, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29593520/iclinfmri-software-for-integrating-functional-mri-techniques-in-presurgical-mapping-and-clinical-studies
#20
Ai-Ling Hsu, Ping Hou, Jason M Johnson, Changwei W Wu, Kyle R Noll, Sujit S Prabhu, Sherise D Ferguson, Vinodh A Kumar, Donald F Schomer, John D Hazle, Jyh-Horng Chen, Ho-Ling Liu
Task-evoked and resting-state (rs) functional magnetic resonance imaging (fMRI) techniques have been applied to the clinical management of neurological diseases, exemplified by presurgical localization of eloquent cortex, to assist neurosurgeons in maximizing resection while preserving brain functions. In addition, recent studies have recommended incorporating cerebrovascular reactivity (CVR) imaging into clinical fMRI to evaluate the risk of lesion-induced neurovascular uncoupling (NVU). Although each of these imaging techniques possesses its own advantage for presurgical mapping, a specialized clinical software that integrates the three complementary techniques and promptly outputs the analyzed results to radiology and surgical navigation systems in a clinical format is still lacking...
2018: Frontiers in Neuroinformatics
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