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https://www.readbyqxmd.com/read/28794974/resting-state-functional-connectivity-changes-due-to-acute-and-short-term-valproic-acid-administration-in-the-baboon-model-of-gge
#1
Felipe S Salinas, Charles Ákos Szabó
Resting-state functional connectivity (FC) is altered in baboons with genetic generalized epilepsy (GGE) compared to healthy controls (CTL). We compared FC changes between GGE and CTL groups after intravenous injection of valproic acid (VPA) and following one-week of orally administered VPA. Seven epileptic (2 females) and six CTL (3 females) baboons underwent resting-state fMRI (rs-fMRI) at 1) baseline, 2) after intravenous acute VPA administration (20 mg/kg), and 3) following seven-day oral, subacute VPA therapy (20-80 mg/kg/day)...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28789983/impaired-brain-network-architecture-in-newly-diagnosed-parkinson-s-disease-based-on-graph-theoretical-analysis
#2
Jinping Fang, Huimin Chen, Zhentang Cao, Ying Jiang, Lingyan Ma, Huizi Ma, Tao Feng
BACKGROUND: Resting state functional magnetic resonance imaging (rs-fMRI) has been applied to investigate topographic structure in Parkinson's disease (PD). Alteration of topographic architecture has been inconsistent in PD AIM: To investigate the network profile of PD using graph theoretical analysis. METHOD: Twenty six newly diagnosed PD and 19 age- and gender- matched healthy controls (HC) were included in our analysis. Small-world profile and topographic profiles (nodal degree, global efficiency, local efficiency, cluster coefficient, shortest path length, betweenness centrality) were measured and compared between groups, with age and gender as covariates...
August 5, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28783763/mapping-altered-brain-connectivity-and-its-clinical-associations-in-adult-moyamoya-disease-a-resting-state-functional-mri-study
#3
Ken Kazumata, Khin Khin Tha, Haruto Uchino, Masaki Ito, Naoki Nakayama, Takeo Abumiya
Detection of subtle ischemic injuries in moyamoya disease may enable optimization of timing of revascularization surgery, and could potentially improve functional outcomes. Resting-state functional magnetic resonance imaging (rs-fMRI) is widely used to study functional organization of the brain, but it remains unclear whether rs-fMRI could elucidate distinct characteristics in moyamoya disease. Here, we aimed to determine changes in a conventional rs-fMRI measure and analyze any associations with clinical symptoms and cerebral hemodynamics...
2017: PloS One
https://www.readbyqxmd.com/read/28782373/correlating-resting-state-functional-mri-connectivity-by-independent-component-analysis-based-epileptogenic-zones-with-intracranial-eeg-localized-seizure-onset-zones-and-surgical-outcomes-in-prospective-pediatric-intractable-epilepsy-study
#4
Varina Boerwinkle, Deepankar Mohanty, Stephen Foldes, Danielle Guffey, Charles G Minard, Lucia Mirea, Aditya Vedantam, Jeffery S Raskin, Sandi Lam, Margaret Bond, P David Adelson, Angus A Wilfong, Daniel J Curry
OBJECTIVE: Prospective investigation determining agreement between the epileptogenic zone(s) (EZ) localization by resting state functional MRI (rs-fMRI) and the seizure onset zone(s) (SOZ) identified by intracranial EEG (ic-EEG) using novel differentiating and ranking criteria of rs-fMRI abnormal independent components in a consecutive heterogeneous pediatric intractable epilepsy population prospectively was conducted. METHODS: The EZ criteria were developed from an initial cohort of 350 patients evaluated for epilepsy surgery over a 3-year period...
August 7, 2017: Brain Connectivity
https://www.readbyqxmd.com/read/28774649/the-dynamic-imprint-of-word-learning-on-the-dorsal-language-pathway
#5
María-Ángeles Palomar-García, Ana Sanjuán, Elisenda Bueichekú, Noelia Ventura-Campos, César Ávila
According to Hickok and Poeppel (2007), the acquisition of new vocabulary rests on the dorsal language pathway connecting auditory and motor areas. The present study tested this hypothesis longitudinally by measuring BOLD signal changes during a verbal repetition task and modulation of resting state functional connectivity (rs-FC) in the dorsal stream. Thirty-five healthy participants, divided into trained and control groups, completed fMRI sessions on days 1, 10, and 24. Between days 1 and 10, the trained group learned 84 new pseudowords associated with 84 native words...
July 31, 2017: NeuroImage
https://www.readbyqxmd.com/read/28769870/altered-coupling-between-motion-related-activation-and-resting-state-brain-activity-in-the-ipsilesional-sensorimotor-cortex-after-cerebral-stroke
#6
Jianping Hu, Juan Du, Qiang Xu, Fang Yang, Fanyong Zeng, Xi-Jian Dai, Xiaoxue Liu, Guangming Lu, Zhiqiang Zhang
Functional connectivity maps using resting-state functional magnetic resonance imaging (rs-fMRI) can closely resemble task fMRI activation patterns, suggesting that resting-state brain activity may predict task-evoked activation or behavioral performance. However, this conclusion was mostly drawn upon a healthy population. It remains unclear whether the predictive ability of resting-state brain activity for task-evoked activation would change under different pathological conditions. This study investigated dynamic changes of coupling between patterns of resting-state functional connectivity (RSFC) and motion-related activation in different stages of cerebral stroke...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28762756/intranasal-oxytocin-selectively-modulates-large-scale-brain-networks-in-humans
#7
Katja Brodmann, Oliver Gruber, Roberto Goya-Maldonado
A growing body of evidence indicates that the neuropeptide oxytocin (OT) alters the neural correlates of socio-emotional and salience processing. Yet the effects of OT over important large-scale networks involved in these processes, such as the default mode (DM), ventral attention (VA) and cingulo-opercular (CO) networks, remain unknown. Therefore, we conducted a placebo-controlled crossover study with intranasal 24IU OT in 38 healthy male subjects using a resting-state fMRI (rs-fMRI) paradigm to investigate its impact over these three candidate networks...
August 1, 2017: Brain Connectivity
https://www.readbyqxmd.com/read/28759710/functional-integrity-in-children-with-anoxic-brain-injury-from-drowning
#8
Mariam Ishaque, Janessa H Manning, Mary D Woolsey, Crystal G Franklin, Elizabeth W Tullis, Christian F Beckmann, Peter T Fox
Drowning is a leading cause of accidental injury and death in young children. Anoxic brain injury (ABI) is a common consequence of drowning and can cause severe neurological morbidity in survivors. Assessment of functional status and prognostication in drowning victims can be extremely challenging, both acutely and chronically. Structural neuroimaging modalities (CT and MRI) have been of limited clinical value. Here, we tested the utility of resting-state functional MRI (rs-fMRI) for assessing brain functional integrity in this population...
July 31, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28755988/acute-affective-reactivity-and-quality-of-life-in-older-adults-with-amnestic-mild-cognitive-impairment-a-functional-mri-study
#9
Ping Ren, Kathi L Heffner, Alanna Jacobs, Feng Lin
OBJECTIVES: Poor quality of life (QoL) is a major concern among older adults with amnestic mild cognitive impairment (MCI). Maladaptive affective regulation and its relevant frontal dysfunction that are often observed in older adults with MCI may provide an insight into the understanding of their QoL. METHODS: In this case-controlled study, participants (MCI patients, N = 18; healthy comparisons [HC], N = 21) completed cognitive tasks, and underwent resting-state functional magnetic resonance imaging (rs-fMRI) immediately before and after the tasks...
June 27, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28755862/ketamine-changes-the-local-resting-state-functional-properties-of-anesthetized-monkey-brain
#10
Jia-Sheng Rao, Zuxiang Liu, Can Zhao, Rui-Han Wei, Wen Zhao, Peng-Yu Tian, Xia Zhou, Zhao-Yang Yang, Xiao-Guang Li
OBJECTIVE: Ketamine is a well-known anesthetic. 'Recreational' use of ketamine common induces psychosis-like symptoms and cognitive impairments. The acute and chronic effects of ketamine on relevant brain circuits have been studied, but the effects of single-dose ketamine administration on the local resting-state functional properties of the brain remain unknown. In this study, we aimed to assess the effects of single-dose ketamine administration on the brain local intrinsic properties...
July 26, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28750618/difference-in-the-functional-connectivity-of-the-dorsolateral-prefrontal-cortex-between-smokers-with-nicotine-dependence-and-individuals-with-internet-gaming-disorder
#11
Xin Ge, Yawen Sun, Xu Han, Yao Wang, Weina Ding, Mengqiu Cao, Yasong Du, Jianrong Xu, Yan Zhou
BACKGROUND: It has been reported that internet gaming disorder (IGD) and smokers with nicotine dependence (SND) share clinical characteristics, such as over-engagement despite negative consequences and cravings. This study is to investigate the alterations in the resting-state functional connectivity (rsFC) of the dorsolateral prefrontal cortex (DLPFC) observed in SND and IGD. In this study, 27 IGD, 29 SND, and 33 healthy controls (HC) underwent a resting-state functional magnetic resonance imaging (rs-fMRI) scan...
July 27, 2017: BMC Neuroscience
https://www.readbyqxmd.com/read/28747782/hybrid-high-order-functional-connectivity-networks-using-resting-state-functional-mri-for-mild-cognitive-impairment-diagnosis
#12
Yu Zhang, Han Zhang, Xiaobo Chen, Seong-Whan Lee, Dinggang Shen
Conventional functional connectivity (FC), referred to as low-order FC, estimates temporal correlation of the resting-state functional magnetic resonance imaging (rs-fMRI) time series between any pair of brain regions, simply ignoring the potentially high-level relationship among these brain regions. A high-order FC based on "correlation's correlation" has emerged as a new approach for abnormality detection of brain disease. However, separate construction of the low- and high-order FC networks overlooks information exchange between the two FC levels...
July 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28735641/risk-and-resilience-brain-networks-in-treatment-resistant-schizophrenia
#13
Eleni P Ganella, Caio Seguin, Cali F Bartholomeusz, Sarah Whittle, Chad Bousman, Cassandra M J Wannan, Maria A Di Biase, Christina Phassouliotis, Ian Everall, Christos Pantelis, Andrew Zalesky
BACKGROUND: Genes, molecules and neural circuits that are associated with, or confer risk to developing schizophrenia have been studied and mapped. It is hypothesized that certain neural systems may counterbalance familial risk of schizophrenia, and thus confer resilience to developing the disorder. This study sought to identify resting-state functional brain connectivity (rs-FC) representing putative risk or resilience endophenotypes in schizophrenia. METHODS: Resting-state functional magnetic resonance imaging (rs-fMRI) was performed in 42 individuals with treatment resistant schizophrenia (TRS), 16 unaffected first-degree family members (UFM) and 42 healthy controls...
July 20, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28734059/localized-reductions-in-resting-state-functional-connectivity-in-children-with-prenatal-alcohol-exposure
#14
Jia Fan, Paul A Taylor, Sandra W Jacobson, Christopher D Molteno, Suril Gohel, Bharat B Biswal, Joseph L Jacobson, Ernesta M Meintjes
Fetal alcohol spectrum disorders (FASD) are characterized by impairment in cognitive function that may or may not be accompanied by craniofacial anomalies, microcephaly, and/or growth retardation. Resting-state functional MRI (rs-fMRI), which examines the low-frequency component of the blood oxygen level dependent (BOLD) signal in the absence of an explicit task, provides an efficient and powerful mechanism for studying functional brain networks even in low-functioning and young subjects. Studies using independent component analysis (ICA) have identified a set of resting-state networks (RSNs) that have been linked to distinct domains of cognitive and perceptual function, which are believed to reflect the intrinsic functional architecture of the brain...
July 22, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28729114/altered-intrinsic-functional-connectivity-in-the-latent-period-of-epileptogenesis-in-a-temporal-lobe-epilepsy-model
#15
Hyoin Lee, Seungmoon Jung, Peter Lee, Yong Jeong
The latent period, a seizure-free phase, is the duration between brain injury and the onset of spontaneous recurrent seizures (SRSs) during epileptogenesis. The latent period is thought to involve several progressive pathophysiological events that lead to the evolution of the chronic epilepsy phase. Hence, it is vital to investigate the changes in the latent period during epileptogenesis in order to better understand temporal lobe epilepsy (TLE), and to achieve early diagnosis and appropriate management of the condition...
July 17, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28727713/local-brain-activity-differences-between-herpes-zoster-and-postherpetic-neuralgia-patients-a-resting-state-functional-mri-study
#16
Song Cao, Ying Li, Wenwen Deng, Bangyong Qin, Yi Zhang, Peng Xie, Jie Yuan, Buwei Yu, Tian Yu
BACKGROUND: Herpes zoster (HZ) can develop into postherpetic neuralgia (PHN), both of which are painful diseases. PHN patients suffer chronic pain and emotional disorders. Previous studies showed that the PHN brain displayed abnormal activity and structural change, but the difference in brain activity between HZ and PHN is still not known. OBJECTIVES: To identify regional brain activity changes in HZ and PHN brains with resting-state functional magnetic resonance imaging (rs-fMRI) technique, and to observe the differences between HZ and PHN patients...
July 2017: Pain Physician
https://www.readbyqxmd.com/read/28727571/altered-putamen-functional-connectivity-is-associated-with-anxiety-disorder-in-parkinson-s-disease
#17
Xixi Wang, Junyi Li, Yongsheng Yuan, Min Wang, Jian Ding, Jiejin Zhang, Lin Zhu, Yuting Shen, Hui Zhang, Kezhong Zhang
In this study, we used resting state-functional magnetic resonance imaging (rs-fMRI) to explore altered putamen functional connectivity (FC) in Parkinson's disease patients with anxiety disorder. We divided 65 Parkinson's disease patients into anxiety (PD-A; n=18) and non-anxiety (PD-NA; n=45) groups based on a Hamilton Anxiety Rating Scale cutoff score of 12. The PD-A patients exhibited altered putamen FC with cortical and subcortical regions. The PD-A patients showed enhanced putamen FC with the caudatum, which correlated with increased emotional processing during anxiety...
July 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/28716961/the-structural-basis-of-large-scale-functional-connectivity-in-the-mouse
#18
Joanes Grandjean, Valerio Zerbi, Joshua Balsters, Nicole Wenderoth, Markus Rudina
Translational neuroimaging requires approaches and techniques that can bridge between multiple different species and disease states. One candidate method, which offers insights into the brain's functional connectivity (FC), is resting state fMRI (rs-fMRI). In both humans and non-human primates, patterns of functional connectivity (often referred to as the functional connectome) have been related to the underlying structural connectivity (structural connectome). Given the recent rise in pre-clinical neuroimaging of mouse models it is an important question whether the mouse functional connectome conforms to the underlying structural connectivity...
July 17, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28700672/prediction-of-clinical-depression-scores-and-detection-of-changes-in-whole-brain-using-resting-state-functional-mri-data-with-partial-least-squares-regression
#19
Kosuke Yoshida, Yu Shimizu, Junichiro Yoshimoto, Masahiro Takamura, Go Okada, Yasumasa Okamoto, Shigeto Yamawaki, Kenji Doya
In diagnostic applications of statistical machine learning methods to brain imaging data, common problems include data high-dimensionality and co-linearity, which often cause over-fitting and instability. To overcome these problems, we applied partial least squares (PLS) regression to resting-state functional magnetic resonance imaging (rs-fMRI) data, creating a low-dimensional representation that relates symptoms to brain activity and that predicts clinical measures. Our experimental results, based upon data from clinically depressed patients and healthy controls, demonstrated that PLS and its kernel variants provided significantly better prediction of clinical measures than ordinary linear regression...
2017: PloS One
https://www.readbyqxmd.com/read/28693073/-resting-state-fmri-study-of-emotional-network-in-patients-with-postconcussion-syndrome
#20
X Zhang, R B Qian, X M Fu, B Lin, D Zhang, C S Xia, X P Wei, C S Niu, Y H Wang
Objective: To discuss functional connectivity changes in the emotional network of patients with post-concussion syndrome (PCS) and their clinical significance by resting-state functional magnetic resonance imaging (rs-fMRI). Methods: Twenty-seven patients with PCS were recruited from the Department of Neurosurgery of Anhui provincial hospital affiliated to Anhui medical university from October 2015 to April 2016, and 27 healthy subjects were recruited as the controls. The Hamilton Anxiety Scale (HAMA) and The Hamilton Depression Scale (HAMD) were used to evaluate the emotional state of two groups of subjects...
July 4, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
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