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https://www.readbyqxmd.com/read/27910491/measurement-of-high-dynamic-range-x-ray-thomson-scattering-spectra-for-the-characterization-of-nano-plasmas-at-lcls
#1
M J MacDonald, T Gorkhover, B Bachmann, M Bucher, S Carron, R N Coffee, R P Drake, K R Ferguson, L B Fletcher, E J Gamboa, S H Glenzer, S Göde, S P Hau-Riege, D Kraus, J Krzywinski, A L Levitan, K-H Meiwes-Broer, C P O'Grady, T Osipov, T Pardini, C Peltz, S Skruszewicz, M Swiggers, C Bostedt, T Fennel, T Döppner
Atomic clusters can serve as ideal model systems for exploring ultrafast (∼100 fs) laser-driven ionization dynamics of dense matter on the nanometer scale. Resonant absorption of optical laser pulses enables heating to temperatures on the order of 1 keV at near solid density conditions. To date, direct probing of transient states of such nano-plasmas was limited to coherent x-ray imaging. Here we present the first measurement of spectrally resolved incoherent x-ray scattering from clusters, enabling measurements of transient temperature, densities, and ionization...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27908653/molecular-changes-in-children-with-heart-failure-undergoing-left-ventricular-assist-device-therapy
#2
Elizabeth Medina, Carmen C Sucharov, Penny Nelson, Shelley D Miyamoto, Brian L Stauffer
OBJECTIVE: To determine whether left ventricular assist device (LVAD) treatment in children with heart failure would result in the modification of molecular pathways involved in heart failure pathophysiology. STUDY DESIGN: Forty-seven explanted hearts from children were studied (16 nonfailing control, 20 failing, and 11 failing post-LVAD implantation [F-LVAD]). Protein expression and phosphorylation states were determined by receptor binding assays and Western blots...
November 29, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27908301/utility-of-b-type-natriuretic-peptides-in-the-assessment-of-patients-with-systemic-sclerosis-associated-pulmonary-hypertension-in-the-pharos-registry
#3
Lorinda Chung, Robert M Fairchild, Daniel E Furst, Shufeng Li, Firas Alkassab, Marcy B Bolster, Mary Ellen Csuka, Chris T Derk, Robyn T Domsic, Aryeh Fischer, Tracy Frech, Mardi Gomberg-Maitland, Jessica K Gordon, Monique Hinchcliff, Vivien Hsu, Laura K Hummers, Dinesh Khanna, Thomas A Jr Medsger, Jerry A Molitor, Ivana R Preston, Elena Schiopu, Lee Shapiro, Faye Hant, Richard Silver, Robert Simms, John Varga, Virginia D Steen, Roham T Zamanian
OBJECTIVES: To assess the utility of B-type natriuretic peptide (BNP) and N-terminal pro-BNP (NT-proBNP) in detecting and monitoring pulmonary hypertension (PH) in systemic sclerosis (SSc). METHODS: PHAROS is a multicenter prospective cohort of SSc patients at high risk for developing pulmonary arterial hypertension (SSc-AR-PAH) or with a definitive diagnosis of SSc-PH. We evaluated 1) the sensitivity and specificity of BNP≥64 and NT-proBNP≥210 pg/mL for the detection of SSc-PAH and/ or SSc-PH in the SSc-AR-PAH population; 2) baseline and longitudinal BNP and NT-proBNP levels as predictors of progression to SSc-PAH and/or SSc-PH; 3) baseline BNP≥180, NT-proBNP≥553 pg/mL, and longitudinal changes in BNP and NT-proBNP as predictors of mortality in SSc-PH diagnosed patients...
November 10, 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27905934/estimation-of-country-specific-and-global-prevalence-of-male-circumcision
#4
Brian J Morris, Richard G Wamai, Esther B Henebeng, Aaron Ar Tobian, Jeffrey D Klausner, Joya Banerjee, Catherine A Hankins
BACKGROUND: Male circumcision (MC) status and genital infection risk are interlinked and MC is now part of HIV prevention programs worldwide. Current MC prevalence is not known for all countries globally. Our aim was to provide estimates for country-specific and global MC prevalence. METHODS: MC prevalence data were obtained by searches in PubMed, Demographic and Health Surveys, AIDS Indicator Surveys, and Behavioural Surveillance Surveys. Male age was ≥15 years in most surveys...
March 1, 2016: Population Health Metrics
https://www.readbyqxmd.com/read/27899810/potential-selection-effects-when-estimating-associations-between-the-infancy-peak-or-adiposity-rebound-and-later-body-mass-index-in-children
#5
C Börnhorst, A Siani, M Tornaritis, D Molnár, L Lissner, S Regber, L Reisch, A De Decker, L A Moreno, W Ahrens, I Pigeot
INTRODUCTION: This study aims to evaluate a potential selection effect caused by exclusion of children with non-identifiable infancy peak (IP) and adiposity rebound (AR) when estimating associations between age and BMI at IP and AR and later weight status. SUBJECTS AND METHODS: In 4 744 children with at least 4 repeated measurements of height and weight in the age interval from 0 to 8 years (37 998 measurements) participating in the IDEFICS/I.Family cohort study, fractional polynomial multi-level models were used to derive individual BMI trajectories...
November 30, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27899381/castration-resistance-in-prostate-cancer-is-mediated-by-the-kinase-nek6
#6
Atish D Choudhury, Anna C Schinzel, Maura B Cotter, Rosina T Lis, Katherine Labella, Ying Jie Lock, Francesca Izzo, Isil Guney, Michaela Bowden, Yvonne Y Li, Jinal Patel, Emily Hartman, Steven A Carr, Monica Schenone, Jacob D Jaffe, Philip W Kantoff, Peter S Hammerman, William C Hahn
In prostate cancer, the development of castration resistance is pivotal in progression to aggressive disease. However, understanding of the pathways involved remains incomplete. In this study, we performed a high-throughput genetic screen to identify kinases that enable tumor formation by androgen-dependent prostate epithelial (LHSR-AR) cells under androgen-deprived conditions. In addition to the identification of known mediators of castration resistance, which served to validate the screen, we identified a mitotic-related serine/threonine kinase, NEK6, as a mediator of androgen-independent tumor growth...
November 29, 2016: Cancer Research
https://www.readbyqxmd.com/read/27893717/androgen-and-ar-contribute-to-breast-cancer-development-and-metastasis-an-insight-of-mechanisms
#7
J Feng, L Li, N Zhang, J Liu, L Zhang, H Gao, G Wang, Y Li, Y Zhang, X Li, D Liu, J Lu, B Huang
The role of androgen and androgen receptor (AR) in breast carcinogenesis has long been a disputed issue. This report provides a mechanistic insight into how androgen and AR contributes to invasion and metastasis of breast cancer. We find that dihydrotestosterone (DHT) is able to induce the epithelial-to-mesenchymal transition in breast cancer cells in an AR-dependent/estrogen receptor-independent manner. This process is dependent on the demethylation activity of lysine-specific demethylase 1A (LSD1) by epigenetically regulating the target genes E-cadherin and vimentin...
November 28, 2016: Oncogene
https://www.readbyqxmd.com/read/27890989/the-burden-of-segregated-respiratory-diseases-in-india-and-the-quality-of-care-in-these-patients-results-from-the-asia-pacific-burden-of-respiratory-diseases-study
#8
Aloke Gopal Ghoshal, G D Ravindran, Paras Gangwal, Girish Rajadhyaksha, Sang-Heon Cho, Abdul Razak Bin Abdul Muttalif, Horng-Chyuan Lin, Sanguansak Thanaviratananich, Shalini Bagga, Rab Faruqi, Shiva Sajjan, Pradeep Shetty, Raeesuddin Syed, Kim K Hamrosi, De Yun Wang
BACKGROUND: Chronic respiratory diseases such as asthma, allergic rhinitis (AR), chronic obstructive pulmonary disease (COPD), and rhinosinusitis are becoming increasingly prevalent in the Asia-Pacific region. The Asia-Pacific Burden of Respiratory Diseases study examined the disease and economic burden of AR, asthma, COPD, and rhinosinusitis across the Asia-Pacific and more specifically India. OBJECTIVES: To estimate the proportion of adults receiving care for asthma, AR, COPD, and rhinosinusitis and assess the economic burden, both direct and indirect of these chronic respiratory disease...
November 2016: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/27888643/correlation-between-the-number-of-allergen-sensitizations-and-immunoglobulin-e-monosensitization-vs-polysensitization
#9
Jacob E Kuperstock, Christopher D Brook, Matthew W Ryan, Michael P Platt
BACKGROUND: The purpose of this study was to determine if total serum immunoglobulin E (IgE) could predict monosensitization compared to polysensitization in patients with allergic rhinitis (AR). METHODS: This was a retrospective study of a cohort of 1073 patients who underwent allergy testing. Differences in total IgE level between unsensitized, monosensitized, and polysensitized subjects were calculated. Pearson correlation coefficient was calculated to determine whether there was a relationship between total IgE level and the number of positive allergen sensitizations...
November 26, 2016: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/27887970/production-and-release-rate-of-37-ar-from-the-ut-triga-mark-ii-research-reactor
#10
Christine Johnson, Steven R Biegalski, Edward J Artnak, Ethan Moll, Derek A Haas, Justin D Lowrey, Craig E Aalseth, Allen Seifert, Emily K Mace, Vincent T Woods, Paul Humble
Air samples were taken at various locations around The University of Texas at Austin's TRIGA Mark II research reactor and analyzed to determine the concentrations of (37)Ar, (41)Ar, and (133)Xe present. The measured ratio of (37)Ar/(41)Ar and historical records of (41)Ar releases were then utilized to estimate an annual average release rate of (37)Ar from the reactor facility. Using the calculated release rate, atmospheric transport modeling was performed in order to determine the potential impact of research reactor operations on nearby treaty verification activities...
November 22, 2016: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/27886391/estimate-of-the-total-costs-of-allergic-rhinitis-in-specialized-care-based-on-real-world-data-the-ferin-study
#11
C Colás, M Brosa, E Antón, J Montoro, A Navarro, M T Dordal, I Dávila, B Fernández-Parra, M D P Ibáñez, M Lluch-Bernal, V Matheu, C Rondón, M C Sánchez, A Valero
BACKGROUND: Despite the socioeconomic importance of allergic rhinitis (AR), very few prospective studies have been performed under conditions of routine clinical practice and with a sufficiently long observation period outside the clinical trial scenario. We prospectively estimated the direct and indirect costs of AR in patients attending specialized clinics in Spain. METHODS: Patients were recruited at random from allergy outpatient clinics in 101 health centers throughout Spain over 12 months...
November 25, 2016: Allergy
https://www.readbyqxmd.com/read/27872477/the-role-of-gata2-in-lethal-prostate-cancer-aggressiveness
#12
REVIEW
Veronica Rodriguez-Bravo, Marc Carceles-Cordon, Yujin Hoshida, Carlos Cordon-Cardo, Matthew D Galsky, Josep Domingo-Domenech
Advanced prostate cancer is a classic example of the intractability and consequent lethality that characterizes metastatic carcinomas. Novel treatments have improved the survival of men with prostate cancer; however, advanced prostate cancer invariably becomes resistant to these therapies and ultimately progresses to a lethal metastatic stage. Consequently, detailed knowledge of the molecular mechanisms that control prostate cancer cell survival and progression towards this lethal stage of disease will benefit the development of new therapeutics...
November 22, 2016: Nature Reviews. Urology
https://www.readbyqxmd.com/read/27866534/-dihydrotestosterone-inhibits-foam-cell-formation-via-a-lectin-like-ox-low-density-lipoprotein-receptor-mediated-mechanism-in-j774-1-cell-line
#13
Y Qiu, H D Hu, B Q Hu, X Y Chen, P Y Xu, L Cui, P Li, C Liu, L Li
Objective: To investigate the effect of dihydrotestosterone (DHT) on lectin-like ox- low-density lipoprotein (LDL) receptor(LOX-1)expression and foam cell formation in the female macrophage cell line J774.1. Methods: In cultured J774.1 cells, after pretreated with DHT at concentrations of 1×10(-9) mol/L and 1×10(-8) mol/L, ox-LDL-induced LOX-1 expression and foam cell formation were investigated by quantitative real-time PCR, Western blotting, and oil-red O staining. Results: DHT at concentrations of 1×10(-9) mol/L and 1×10(-8) mol/L inhibited ox-LDL-induced LOX-1 mRNA (2...
November 15, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27853660/segmental-surface-referencing-during-intraoperative-three-dimensional-image-guided-spine-navigation-an-early-validation-with-comparison-to-automated-referencing
#14
Amro F Al-Habib, Salah Al-Akkad
Study Design Interventional human cadaver study. Objective Intraoperative three-dimensional (3-D)-guided navigation improves spine instrumentation accuracy. However, image acquisition may need to be repeated with segment hypermobility or distant target from reference frame (RF). The current study evaluates the usefulness of internal metal fiducials (IMFs) as surface references in enhancing registration accuracy and avoiding repeating imaging. Methods Six fresh-frozen cadaveric human torsos were utilized...
December 2016: Global Spine Journal
https://www.readbyqxmd.com/read/27853434/expression-of-steroid-receptors-in-ameloblasts-during-amelogenesis-in-rat-incisors
#15
Sophia Houari, Sophia Loiodice, Katia Jedeon, Ariane Berdal, Sylvie Babajko
Endocrine disrupting chemicals (EDCs) play a part in the modern burst of diseases and interfere with the steroid hormone axis. Bisphenol A (BPA), one of the most active and widely used EDCs, affects ameloblast functions, leading to an enamel hypomineralization pattern similar to that of Molar Incisor Hypomineralization (MIH). In order to explore the molecular pathways stimulated by BPA during amelogenesis, we thoroughly investigated the receptors known to directly or indirectly mediate the effects of BPA. The expression patterns of high affinity BPA receptors (ERRγ, GPR30), of ketosteroid receptors (ERs, AR, PGR, GR, MR), of the retinoid receptor RXRα, and PPARγ were established using RT-qPCR analysis of RNAs extracted from microdissected enamel organ of adult rats...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27837571/maternal-screening-for-early-postnatal-vulnerability
#16
V G Vivilaki, V Dafermos, Ev Patelarou, D Bick, Ar Syngelaki, N D Tsopelas, P Bitsios, E T Petridou, Al N Vgontzas, Chr Lionis
Research has highlighted the wide impact of maternal mental health problems during and beyond the postpartum period and the public health role of community health professionals in early detection of women who may be at risk. This paper aims to describe, explore and test an a priori hypothesised conceptual model of postnatal experience, identifying the relationships between postnatal mental vulnerability and postnatal adjustment to maternal roles and attitudes, marital/partner-relationship and sense of coherence...
July 2016: Psychiatrikē, Psychiatriki
https://www.readbyqxmd.com/read/27836045/identification-of-effective-treatment-criteria-for-use-in-targeted-selective-treatment-programs-to-control-haemonchosis-in-periparturient-ewes-in-ontario-canada
#17
T Westers, A Jones-Bitton, P Menzies, J VanLeeuwen, Z Poljak, A S Peregrine
Haemonchosis is often associated with late gestation and parturition in ewes in Canada. Due to widespread concerns about development of anthelmintic resistance (AR), targeted selective treatment (TST), where individual animals are treated with an anthelmintic rather than the entire flock, is a possible strategy to control clinical signs in recently lambed ewes while still maintaining parasite refugia. Performing fecal egg counts (FEC) on individual animals is often cost-prohibitive, so indicators that identify ewes with high FEC are essential for TST programs...
November 1, 2016: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/27826442/pronuclear-formation-by-icsi-using-chemically-activated-ovine-oocytes-and-zona-pellucida-bound-sperm
#18
J E Hernández-Pichardo, Y Ducolomb, S Romo, M E Kjelland, R Fierro, F Casillas, M Betancourt
BACKGROUND: In order to improve ICSI, appropiate sperm selection and oocyte activation is necessary. The objective of the present study was to determine the efficiency of fertilization using ICSI with chemically activated ovine oocytes and sperm selected by swim up (SU) or swim up + zona pellucida (SU + ZP) binding. RESULTS: Experiment 1, 4-20 replicates with total 821 in vitro matured oocytes were chemically activated with ethanol, calcium ionophore or ionomycin, to determine oocyte activation (precense of one PN)...
2016: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/27825210/infrared-spectroscopy-and-theory-of-the-formaldehyde-cation-and-its-hydroxymethylene-isomer
#19
D T Mauney, J D Mosley, L R Madison, A B McCoy, M A Duncan
Pulsed discharges in supersonic expansions containing the vapor of different precursors (formaldehyde, methanol) produce the m/z = 30 cations with formula [H2,C,O](+). The corresponding [H2,C,O](+) Ar complexes are produced under similar conditions with argon added to the expansion gas. These ions are mass selected in a time-of-flight spectrometer and studied with infrared laser photodissociation spectroscopy. Spectra in the 2300-3000 cm(-1) region produce very different vibrational patterns for the ions made from different precursors...
November 7, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/27819678/tet2-binds-the-androgen-receptor-and-loss-is-associated-with-prostate-cancer
#20
M L Nickerson, S Das, K M Im, S Turan, S I Berndt, H Li, H Lou, S A Brodie, J N Billaud, T Zhang, A J Bouk, D Butcher, Z Wang, L Sun, K Misner, W Tan, A Esnakula, D Esposito, W Y Huang, R N Hoover, M A Tucker, J R Keller, J Boland, K Brown, S K Anderson, L E Moore, W B Isaacs, S J Chanock, M Yeager, M Dean, T Andresson
Genetic alterations associated with prostate cancer (PCa) may be identified by sequencing metastatic tumour genomes to identify molecular markers at this lethal stage of disease. Previously, we characterized somatic alterations in metastatic tumours in the methylcytosine dioxygenase ten-eleven translocation 2 (TET2), which is altered in 5-15% of myeloid, kidney, colon and PCas. Genome-wide association studies previously identified non-coding risk variants associated with PCa and melanoma. We perform fine-mapping of PCa risk across TET2 using genotypes from the PEGASUS case-control cohort and identify six new risk variants in introns 1 and 2...
November 7, 2016: Oncogene
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