keyword
MENU ▼
Read by QxMD icon Read
search

Ar d

keyword
https://www.readbyqxmd.com/read/29138225/androgen-signaling-expands-%C3%AE-cell-mass-in-male-rats-and-%C3%AE-cell-androgen-receptor-is-degraded-under-high-glucose-conditions
#1
Naoki Harada, Yasuhiro Yoda, Yusuke Yotsumoto, Tatsuya Masuda, Yuji Takahashi, Takahiro Katsuki, Kenji Kai, Nobuaki Shiraki, Hiroshi Inui, Ryoichi Yamaji
A deficient pancreatic β-cell mass increases the risk of type 2 diabetes mellitus. Here, we investigated the effects of testosterone on the development of pancreatic β-cell mass in male rats. The β-cell mass of male rats castrated at 6 weeks of age was reduced to ~30% of that of control rats at 16 weeks of age, and castration caused glucose intolerance. Loss of β-cell mass occurred due to decreases in islet density/pancreas and β-cell cluster size. Castration was negatively associated with the number of Ki67-positive β-cells and positively associated with the number of TUNEL-positive β-cells...
November 14, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29130983/prevalence-and-clinical-characteristics-of-local-allergic-rhinitis-in-children-sensitized-to-house-dust-mites
#2
Eun Kyo Ha, Min Sun Na, Shinhae Lee, Heysung Baek, Seung Jin Lee, Youn Ho Sheen, Young-Ho Jung, Kyung Suk Lee, Mi Ae Kim, Hye Mi Jee, Man Yong Han
OBJECTIVE: The prevalence of local allergic rhinitis (LAR) in nonatopic children remains unknown. This study aimed to determine the prevalence, clinical characteristics, and severity of LAR in children in comparison to classical allergic rhinitis (AR) and nonallergic rhinitis (NAR). STUDY DESIGN: A total of 145 children (aged 1-18 years) were enrolled and classified into 3 groups (AR, NAR, and LAR) based on a skin prick test (SPT) and a nasal provocation test (NPT) with house dust mite, i...
November 10, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29126837/antiandrogens-reduce-intratumoral-androgen-concentrations-and-induce-androgen-receptor-expression-in-castration-resistant-prostate-cancer-xenografts
#3
Matias Knuuttila, Arfa Mehmood, Riikka Huhtaniemi, Emrah Yatkin, Merja R Häkkinen, Riikka Oksala, Teemu D Laajala, Henrik Ryberg, David J Handelsman, Tero Aittokallio, Seppo Auriola, Claes Ohlsson, Asta Laiho, Laura L Elo, Petra Sipilä, Sari I Mäkelä, Matti Poutanen
The development of castration-resistant prostate cancer (CRPC) is associated with the activation of intratumoral androgen biosynthesis and an increase in androgen receptor (AR) expression. We recently demonstrated that similarly to the clinical CRPC, orthotopically grown castration-resistant VCaP (CR-VCaP) xenografts express high levels of AR and retain intratumoral androgen concentrations similar to tumors grown in intact mice. Here, we show that antiandrogen treatment (enzalutamide or ARN-509) significantly reduced (10-fold, P < 0...
November 7, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/29124904/mind-the-gaps-in-research-on-the-control-of-gastrointestinal-nematodes-of-farmed-ruminants-and-pigs
#4
J Charlier, S M Thamsborg, D J Bartley, P J Skuce, F Kenyon, T Geurden, H Hoste, A R Williams, S Sotiraki, J Höglund, C Chartier, P Geldhof, J van Dijk, L Rinaldi, E R Morgan, G von Samson-Himmelstjerna, J Vercruysse, E Claerebout
Gastrointestinal (GI) nematode control has an important role to play in increasing livestock production from a limited natural resource base and to improve animal health and welfare. In this synthetic review, we identify key research priorities for GI nematode control in farmed ruminants and pigs, to support the development of roadmaps and strategic research agendas by governments, industry and policymakers. These priorities were derived from the DISCONTOOLS gap analysis for nematodes and follow-up discussions within the recently formed Livestock Helminth Research Alliance (LiHRA)...
November 10, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29123236/induction-of-glucose-uptake-in-skeletal-muscle-by-central-leptin-is-mediated-by-muscle-%C3%AE-2-adrenergic-receptor-but-not-by-ampk
#5
Tetsuya Shiuchi, Chitoku Toda, Shiki Okamoto, Eulalia A Coutinho, Kumiko Saito, Shinji Miura, Osamu Ezaki, Yasuhiko Minokoshi
Leptin increases glucose uptake and fatty acid oxidation (FAO) in red-type skeletal muscle. However, the mechanism remains unknown. We have investigated the role of β2-adrenergic receptor (AR), the major β-AR isoform in skeletal muscle, and AMPK in leptin-induced muscle glucose uptake of mice. Leptin injection into the ventromedial hypothalamus (VMH) increased 2-deoxy-D-glucose (2DG) uptake in red-type skeletal muscle in wild-type (WT) mice accompanied with increased phosphorylation of the insulin receptor (IR) and Akt as well as of norepinephrine (NE) turnover in the muscle...
November 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29122965/the-impact-of-dairy-protein-during-limb-immobilization-and-recovery-on-muscle-size-and-protein-synthesis-a-randomized-controlled-trial
#6
Cameron J Mitchell, Randall F D'Souza, Sarah M Mitchell, Vandre Casagrande Figueiredo, Benjamin F Miller, Karyn L Hamilton, Frederick F Peelor, Marcelli Coronet, Chantal A Pileggi, Brenan Durainayagam, Aaron C Fanning, Sally D Poppitt, David Cameron-Smith
Muscle disuse results in the loss of muscular strength and size, due to an imbalance between protein synthesis (MPS) and breakdown (MPB). Protein ingestion stimulates MPS, although it is not established if protein is able to attenuate muscle loss with immobilization (IM) or influence the recovery consisting of ambulatory movement followed by resistance training (RT). Thirty men (49.9±0.6 years) underwent 14 days of unilateral leg IM, 14 days of ambulatory recovery (AR) and a further 6 RT sessions over 14 days...
November 9, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29122702/estrogenic-effects-following-larval-exposure-to-the-putative-anti-estrogen-fulvestrant-in-the-fathead-minnow-pimephales-promelas
#7
Jonathan M Ali, Michael T Palandri, Alex T Kallenbach, Edwin Chavez, Jonathan Ramirez, Sathaporn Onanong, Daniel D Snow, Alan S Kolok
The objective of the present study was to investigate the consequences of early-life exposure to fulvestrant on estrogenic gene expression in fathead minnow larvae. To address this objective, fathead minnow larvae were exposed to fulvestrant (ICI 182,780) during the window of sexual differentiation between 0 to 30 days post-hatch (dph). The four treatment groups in this study included: filtered water controls (never exposed), solvent controls (ethanol 0.01%), and nominally low (0.10μg/L) and high (10.0μg/L) doses of fulvestrant...
November 6, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29121805/prostate-cancer-xenograft-inhibitory-activity-and-pharmacokinetics-of-decursinol-a-metabolite-of-angelica-gigas-pyranocoumarins-in-mouse-models
#8
Wei Wu, Su-Ni Tang, Yong Zhang, Manohar Puppala, Timothy K Cooper, Chengguo Xing, Cheng Jiang, Junxuan Lü
We have previously shown that the ethanol extract of dried Angelica gigas Nakai (AGN) root exerts anticancer activity against androgen receptor (AR)-negative human DU145 and PC-3 prostate cancer xenografts and primary carcinogenesis in the transgenic adenocarcinoma of mouse prostate (TRAMP) model. The major pyranocoumarin isomers decursin (D) and decursinol angelate (DA), when provided at equi-molar intake to that provided by AGN extract, accounted for the inhibitory efficacy against precancerous epithelial lesions in TRAMP mice...
November 9, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29121499/atorvastatin-accelerates-clearance-of-lipoprotein-remnants-generated-by-activated-brown-fat-to-further-reduce-hypercholesterolemia-and-atherosclerosis
#9
Geerte Hoeke, Yanan Wang, Andrea D van Dam, Isabel M Mol, Eveline Gart, Henk G Klop, Susan M van den Berg, Elsbet H Pieterman, Hans M G Princen, Albert K Groen, Patrick C N Rensen, Jimmy F P Berbée, Mariëtte R Boon
BACKGROUND AND AIMS: Activation of brown adipose tissue (BAT) reduces both hyperlipidemia and atherosclerosis by increasing the uptake of triglyceride-derived fatty acids by BAT, accompanied by formation and clearance of lipoprotein remnants. We tested the hypothesis that the hepatic uptake of lipoprotein remnants generated by BAT activation would be accelerated by concomitant statin treatment, thereby further reducing hypercholesterolemia and atherosclerosis. METHODS: APOE*3-Leiden...
October 26, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29121144/positron-emission-tomography-computed-tomography-based-assessments-of-androgen-receptor-expression-and-glycolytic-activity-as-a-prognostic-biomarker-for-metastatic-castration-resistant-prostate-cancer
#10
Josef J Fox, Somali C Gavane, Estelle Blanc-Autran, Sadek Nehmeh, Mithat Gönen, Brad Beattie, Hebert A Vargas, Heiko Schöder, John L Humm, Samson W Fine, Jason S Lewis, Stephen B Solomon, Joseph R Osborne, Darren Veach, Charles L Sawyers, Wolfgang A Weber, Howard I Scher, Michael J Morris, Steven M Larson
Importance: Androgen receptor-signaling inhibitor (ARSi) drugs prolong life in metastatic castration-resistant prostate cancer (mCRPC), but such tumors eventually become resistant and progress. Comprehensive positron emission tomography/computed tomography (PET/CT) imaging using fluoro-2-D-deoxyglucose F 18 ([18F]-FDG) for glycolysis (Glyc) and fluorodihydrotestosterone F 18 ([18F]-FDHT) for androgen receptor (AR) expression determine heterogeneity of imaging phenotypes, which may be useful in distinguishing patients who will benefit from ARSi drugs from those who need alternative treatments...
November 9, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/29103416/inhibitory-effect-of-phlai-capsules-on-skin-test-responses-among-allergic-rhinitis-patients-a-randomized-three-way-crossover-study
#11
Pattara Tanticharoenwiwat, Prapasri Kulalert, Thaweephol Dechatiwongse Na Ayudhya, Sittichai Koontongkaew, Weena Jiratchariyakul, Ruedee Soawakontha, Prakongsiri Booncong, Orapan Poachanukoon
BACKGROUND: Zingiber cassumunar Roxb., commonly known as Phlai in Thai, has been used as a traditional medicine in Thailand for the treatment of various diseases, including inflammation and chronic airway disease. OBJECTIVE: The purpose of this study was to assess the antihistaminic effect of Phlai on skin testing. DESIGN, SETTING, PARTICIPANTS AND INTERVENTION: This was a randomized, open-label, three-way crossover study. Twenty allergic rhinitis (AR) patients were enrolled...
November 2017: Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29100269/activation-induced-cytidine-deaminase-prevents-pro-b-cell-acute-lymphoblastic-leukemia-by-functioning-as-a-negative-regulator-in-rag1-deficient-pro-b-cells
#12
Franziska Auer, Deborah Ingenhag, Stefan Pinkert, Sven Kracker, Salima Hacein-Bey-Abina, Marina Cavazzana, Michael Gombert, Alberto Martin-Lorenzo, Min-Hui Lin, Carolina Vicente-Dueñas, Isidro Sánchez-García, Arndt Borkhardt, Julia Hauer
Activation-induced cytidine deaminase (AID) is essential for somatic hypermutation and class switch recombination in mature B-cells, while AID was also shown to play a role in developing pre-BCR/BCR-positive B-cells of the bone marrow. To further elucidate a potential function of Aid in the bone marrow prior to V(D)J-recombination, we utilized an in vivo model which exerts a B-cell developmental arrest at the pro-B cell stage with low frequencies of pro-B cell acute lymphoblastic leukemia (pro-B ALL) development...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29098099/life-threatening-irinotecan-induced-toxicity-in-an-adult-patient-with-alveolar-rhabdomyosarcoma-the-role-of-a-ugt1a1-polymorphism
#13
Arnaud Jannin, Benjamin Hennart, Antoine Adenis, Bruno Chauffert, Nicolas Penel
Alveolar rhabdomyosarcoma (AR) in adult patients is an exceptional malignancy. Management of AR is based on (neo)adjuvant chemotherapy combining ifosfamide, vincristine, and actinomycin D and local curative-intent surgery/radiotherapy. In cases of relapsing AR, the combination of temozolomide/irinotecan is regarded as a possible option. Here we describe life-threatening long-lasting toxicity related to the 1st cycle of irinotecan-based chemotherapy in a 56-year-old woman suffering from locally advanced and metastatic head and neck AR...
2017: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/29094019/serum-25-hydroxyvitamin-d-inversely-associated-with-blood-eosinophils-in-patients-with-persistent-allergic-rhinitis
#14
Hai-Yan Wu, Jin-Xiang Chen, Hui-Qin Tian, Xiu-Ling Zhang, Hai-Yan Bian, Lei Cheng
Objective: The relationship between vitamin D and allergic rhinitis (AR) remains unclear. The present study investigated their association by examining serum 25-hydroxyvitamin D (25(OH)D) levels, blood eosinophils, and the expression of vitamin D receptors (VDR) on nasal mucosa in patients with AR. Methods: A total of 32 patients with persistent AR and 25 controls were enrolled in this study. Serum 25(OH)D levels were detected by enzyme-linked immunosorbent assay, and eosinophils in the peripheral blood were examined by an automated hematology system, while VDR expression on inferior turbinate mucosa was assessed by immunohistochemistry...
October 2017: Asia Pacific Allergy
https://www.readbyqxmd.com/read/29089489/thioredoxin-1-protects-against-androgen-receptor-induced-redox-vulnerability-in-castration-resistant-prostate-cancer
#15
Govindi J Samaranayake, Clara I Troccoli, Mai Huynh, Rolando D Z Lyles, Karen Kage, Andrew Win, Vishalakshi Lakshmanan, Deukwoo Kwon, Yuguang Ban, Steven Xi Chen, Enrique Rodriguez Zarco, Merce Jorda, Kerry L Burnstein, Priyamvada Rai
Androgen deprivation (AD) therapy failure leads to terminal and incurable castration-resistant prostate cancer (CRPC). We show that the redox-protective protein thioredoxin-1 (TRX1) increases with prostate cancer progression and in androgen-deprived CRPC cells, suggesting that CRPC possesses an enhanced dependency on TRX1. TRX1 inhibition via shRNA or a phase I-approved inhibitor, PX-12 (untested in prostate cancer), impedes the growth of CRPC cells to a greater extent than their androgen-dependent counterparts...
October 31, 2017: Nature Communications
https://www.readbyqxmd.com/read/29080824/prediction-of-arsenic-and-antimony-transporter-major-intrinsic-proteins-from-the-genomes-of-crop-plants
#16
Abul Kalam Azad, Jahed Ahmed, Md Asraful Alum, Md Mahbub Hasan, Takahiro Ishikawa, Yoshihiro Sawa
Major intrinsic proteins (MIPs), commonly known as aquaporins, transport water and non-polar small solutes. Comparing the 3D models and the primary selectivity-related motifs (two Asn-Pro-Ala (NPA) regions, the aromatic/arginine (ar/R) selectivity filter, and Froger's positions (FPs)) of all plant MIPs that have been experimentally proven to transport arsenic (As) and antimony (Sb), some substrate-specific signature sequences (SSSS) or specificity determining sites (SDPs) have been predicted. These SSSS or SDPs were determined in 543 MIPs found in the genomes of 12 crop plants; the As and Sb transporters were predicted to be distributed in noduline-26 like intrinsic proteins (NIPs), and every plant had one or several As and Sb transporter NIPs...
October 26, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29072505/profiling-of-anthocyanidins-against-transcriptional-activities-of-steroid-and-nuclear-receptors
#17
Barbora Pastorková, Petr Illés, Zdeněk Dvořák
The aim of current study was to evaluate the effect of the most common anthocyanidins (cyanidin, delphinidin, malvidin, pelargonidin, and peonidin) on the transcriptional activity of steroid and nuclear receptors. The activities of steroid receptors - progesterone receptor (PR), estrogen receptor (ER), androgen receptor (AR), glucocorticoid receptor (GR), and nuclear receptors - vitamin D receptor (VDR), retinoid X receptor (RXR), retinoic acid receptor (RAR), pregnane X receptor (PXR), and thyroid receptor (TR) were assessed using either stable transfected luciferase gene reporter cell lines or transiently transfected cell lines...
October 26, 2017: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/29069546/contrasting-photolytic-and-thermal-decomposition-of-phenyl-azidoformate-the-curtius-rearrangement-versus-intramolecular-c-h-amination
#18
Huabin Wan, Jian Xu, Qian Liu, Hongmin Li, Yan Lu, Manabu Abe, Xiaoqing Zeng
The decomposition of phenyl azidoformate, PhOC(O)N3, was studied by combining matrix isolation spectroscopy and quantum chemical calculations. Upon UV laser photolysis (193 and 266 nm), the azide isolated in cryogenic noble gas matrices (Ne and Ar, 2.8 K) decomposes into N2 and a novel oxycarbonylnitrene PhOC(O)N, which was identified by matrix-isolation IR spectroscopy (with (15)N labeling) and EPR spectroscopy (|D/hc| = 1.620 cm(-1) and |E/hc| = 0.024 cm(-1)). Subsequent visible-light irradiation (532 nm) causes rearrangement of the nitrene into phenoxy isocyanate PhONCO with complex secondary fragmentation (PhO· + ·NCO) and radical recombination species in matrices...
November 2, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29068862/impact-of-polyphenol-supplementation-on-acute-and-chronic-response-to-resistance-training
#19
Kyle S Beyer, Jeffrey R Stout, David H Fukuda, Adam R Jajtner, Jeremy R Townsend, David D Church, Ran Wang, Joshua J Riffe, Tyler W D Muddle, Kelli A Herrlinger, Jay R Hoffman
Beyer, KS, Stout, JR, Fukuda, DH, Jajtner, AR, Townsend, JR, Church, DD, Wang, R, Riffe, JJ, Muddle, TWD, Herrlinger, KA, and Hoffman, JR. Impact of polyphenol supplementation on acute and chronic response to resistance training. J Strength Cond Res 31(11): 2945-2954, 2017-This study investigated the effect of a proprietary polyphenol blend (PPB) on acute and chronic adaptations to resistance exercise. Forty untrained men were assigned to control, PPB, or placebo. Participants in PPB or placebo groups completed a 4-week supplementation period (phase I), an acute high-volume exercise bout (phase II), and a 6-week resistance training program (phase III); whereas control completed only testing during phase II...
November 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29063941/experimental-and-theoretical-study-of-the-collisional-quenching-of-s-1-d-by-ar
#20
Manuel Lara, C Berteloite, M Paniagua, F Dayou, S D Le Picard, J-M Launay
We present an experimental and theoretical investigation of the deactivation rate of S((1)D) atoms by collisions with argon. Kinetic measurements were performed at temperatures from 5.8 K to 298 K in cold uniform supersonic flows using a CRESU (Cinétique de Réaction en Ecoulement Supersonique Uniforme or Reaction Kinetics in a Uniform Supersonic Flow) apparatus. In order to simulate them, ab initio electronic structure calculations using internally contracted MRCI methodology were performed to describe the interaction...
November 1, 2017: Physical Chemistry Chemical Physics: PCCP
keyword
keyword
111081
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"