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https://www.readbyqxmd.com/read/28910660/toxic-effects-of-pb-2-entering-sperm-through-ca-2-channels-in-the-freshwater-crab-sinopotamon-henanense
#1
Na Li, Peng Xu, Wei-Xin Jing, Jiang-Shiou Hwang, Lan Wang
Lead (Pb) is a heavy metal that can damage animal sperm. To study the effects of Pb on calcium homeostasis and calcium channel in the sperm of freshwater crab Sinopotamon henanense, the induction of acrosome reaction (AR) and acrosin activity were investigated when crabs were exposed to different Pb concentrations (0, 3.675, 7.35, 14.7, 29.4 and 58.8mg/L) for 3, 5 and 7 d separately. Fluorescent probe Fluo-3/AM was loaded into the sperm, and [Ca(2+)] in the sperm was measured by fluorescence microscopy and using microplate reader...
September 4, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28910079/silver-loaded-aluminosilicate-aerogels-as-iodine-sorbents
#2
Brian J Riley, Jared O Kroll, Jacob A Peterson, Josef Matyáš, Matthew J Olszta, Xiaohong Li, John D Vienna
In this paper, aluminosilicate aerogels were used as scaffolds for silver nanoparticles to capture I2(g). The starting materials for these scaffolds included Na-Al-Si-O and Al-Si-O aerogels, both synthesized from metal alkoxides. The Ag(0) particles were added by soaking the aerogels in aqueous AgNO3 solutions followed by drying and Ag(+) reduction under H2/Ar to form Ag(0) crystallites within the aerogel matrix. In some cases, aerogels were thiolated with 3-(mercaptopropyl)trimethoxysilane as an alternative method for binding Ag(+)...
September 14, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28905400/somatostatin-receptor-subtype-1-as-a-potential-diagnostic-marker-and-therapeutic-target-in-prostate-cancer
#3
Sergio Pedraza-Arévalo, Daniel Hormaechea-Agulla, Enrique Gómez-Gómez, María J Requena, Luke A Selth, Manuel D Gahete, Justo P Castaño, Raul M Luque
BACKGROUND: Prostate cancer (PCa) is a highly prevalent neoplasia that is strongly influenced by the endocrine system. Somatostatin (SST) and its five receptors (sst1-5 encoded by SSTR1-5 genes) comprise a pleiotropic system present in most endocrine-related cancers, some of which are successfully treated with SST analogs. Interestingly, it has been reported that SSTR1 is overexpressed in PCa, but its regulation, functional role, and clinical implications are still poorly known. METHODS: PCa specimens (n = 52) from biopsies and control prostates from cystoprostatectomies (n = 12), as well as in silico databases were used to evaluate SSTR1 and miRNAs expression...
September 14, 2017: Prostate
https://www.readbyqxmd.com/read/28902467/eaaci-guidelines-on-allergen-immunotherapy-prevention-of-allergy
#4
REVIEW
Susanne Halken, Desiree Larenas-Linnemann, Graham Roberts, Moises A Calderón, Elisabeth Angier, Oliver Pfaar, Dermot D Ryan, Ioana Agache, Ignacio J I J Ansotegui, Stefania Arasi, George Du Toit, Montserrat Fernandez-Rivas, Roy Geerth van Wijk, Marek Jutel, Jörg Kleine-Tebbe, Susanne Lau, Paolo M Matricardi, Giovanni B Pajno, Nikolaos G Papadopoulos, Martin Penagos, Alexandra F Santos, Gunter J Sturm, Frans Timmermans, R Van Ree, Eva-Maria Varga, Ulrich Wahn, Maria Kristiansen, Sangeeta Dhami, Aziz Sheikh, Muraro Antonella
Allergic diseases are common and frequently coexist. Allergen immunotherapy (AIT) is a disease-modifying treatment for IgE-mediated allergic disease with effects beyond cessation of AIT that may include important preventive effects. The European Academy of Allergy and Clinical Immunology (EAACI) has developed a clinical practice guideline to provide evidence-based recommendations for AIT for prevention of i) development of allergic comorbidities in those with established allergic diseases, ii) development of first allergic condition and iii) allergic sensitization...
September 13, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28900498/correlation-between-erg-fusion-protein-and-androgen-receptor-expression-by-immunohistochemistry-in-prostate-possible-role-in-diagnosis-and-therapy
#5
Amir Hassan Navaei, Beatriz A Walter, Vanessa Moreno, Svetlana D Pack, Peter Pinto, Maria J Merino
Background: Recent discovery of gene rearrangements have brought a new look to the molecular pathogenesis of cancer. Gene fusions occur in nearly 60% of prostate adenocarcinoma, being the TMPRSS2-ERG one of the most common. Evidence supports the role of ERG fusion in tumorigenesis, progression and invasion via effecting pathways such as WNT, MYC, uPA, PI3K/AKT/PTEN, RAS/RAF/MAPF, NKX3.1, GST-pi and androgen receptor (AR) mediated signaling. Most of the ERG fusions involve 5'-partners androgen responsive. Therefore, we aimed to evaluate AR and ERG fusion protein expression on prostate tissue to find clinicopathological applications and possible role in therapy...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28898962/occupational-rhinoconjunctivitis-caused-by-the-common-indoor-plant-hoya-compacta
#6
D Sherson, A D Nielsen, C G Mortz, L Vestergaard, L P A Brandt, E Jørs, J Bælum
Background: Allergic reactions to the common house plant Hoya compacta (HC) have not previously been described. Aims: To confirm HC as the cause of rhinoconjunctivitis in three horticultural workers. Methods: Greenhouse working conditions were reproduced in our challenge chamber. Results: All three cases developed rhinoconjunctivitis when working with HC plants. A control challenge was performed in two cases with iceberg lettuce causing no symptoms...
August 1, 2017: Occupational Medicine
https://www.readbyqxmd.com/read/28898537/stabilizing-an-amyloidogenic-%C3%AE-6-light-chain-variable-domain
#7
Oscar D Luna-Martínez, Alejandra Hernández-Santoyo, Myriam I Villalba-Velázquez, Rosalba Sánchez-Alcalá, D Alejandro Fernández-Velasco, Baltazar Becerril
Light chain amyloidosis is a lethal disease where vital organs are damaged by the fibrillar aggregation of monoclonal light chains. λ6a is an immunoglobulin light chain encoded by the germ line gene segment implicated in this disease. AR is a patient-derived germ line variant with a markedly low thermodynamic stability and prone to form fibrils in vitro in less than an hour. Here, we sought to stabilize this domain by mutating some residues back to the germ line sequence, and the most stabilizing mutations were the single mutant AR-F21I and the double mutant AR-F21/IV104L, both located in the hydrophobic core...
September 12, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28893830/assessment-of-paravalvular-leakage-after-transcatheter-aortic-valve-implantation-add-clinical-signs-to-echocardiographic-data
#8
Corstiaan A den Uil, Mihai Strachinaru, Ben van der Hoven, J Han J Meeder
A 62-year old male with pulmonary fibrosis and aortic valve stenosis underwent TAVI (Corevalve Evolut XL 34 mm) in the build-up for lung transplantation (LuTx). Following post-dilation for a large annular perimeter, moderate paravalvular aortic regurgitation (AR) was observed. After 6 weeks, he was admitted to the ICU with respiratory failure(A). TTE demonstrated residual mild AR (based on a small excentric paravalvular AR jet, <10% circumferential extent, pressure half-time was not reliably measured) and together with borderline elevated NT-pro-BNP, the consultant cardiologist authorized LuTx listing...
September 11, 2017: Echo Research and Practice
https://www.readbyqxmd.com/read/28888989/noradrenaline-oxymetazoline-and-phorbol-myristate-acetate-induce-distinct-functional-actions-and-phosphorylation-patterns-of-%C3%AE-1a-adrenergic-receptors
#9
Rocío Alcántara-Hernández, Aurelio Hernández-Méndez, M Teresa Romero-Ávila, Marco A Alfonzo-Méndez, André S Pupo, J Adolfo García-Sáinz
In LNCaP cells that stably express α1A-adrenergic receptors, oxymetazoline increased intracellular calcium and receptor phosphorylation, however, this agonist was a weak partial agonist, as compared to noradrenaline, for calcium signaling. Interestingly, oxymetazoline-induced receptor internalization and desensitization displayed greater effects than those induced by noradrenaline. Phorbol myristate acetate induced modest receptor internalization and minimal desensitization. α1A-Adrenergic receptor interaction with β-arrestins (colocalization/coimmunoprecipitation) was induced by noradrenaline and oxymetazoline and, to a lesser extent, by phorbol myristate acetate...
September 6, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28882624/network-pharmacology-analysis-of-the-anti-cancer-pharmacological-mechanisms-of-ganoderma-lucidum-extract-with-experimental-support-using-hepa1-6-bearing-c57-bl-6-mice
#10
Ruo-Lin Zhao, Yu-Min He
ETHNOPHARMACOLOGICAL RELEVANCE: Ganoderma lucidum (GL) is an oriental medical fungus, which was used to prevent and treat many diseases. Previously, the effective components of Ganoderma lucidum extract (GLE) were extracted from two kinds of GL, Ganoderma lucidum (Leyss. Ex Fr.) Karst. and Ganoderma sinense Zhao, Xu et Zhang, which have been used for adjuvant anti-cancer clinical therapy for more than 20 years. However, its concrete active components and its regulation mechanisms on tumor are unclear...
September 4, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28881726/modulation-of-paracrine-signaling-by-cd9-positive-small-extracellular-vesicles-mediates-cellular-growth-of-androgen-deprived-prostate-cancer
#11
Carolina Soekmadji, James D Riches, Pamela J Russell, Jayde E Ruelcke, Stephen McPherson, Chenwei Wang, Chris M Hovens, Niall M Corcoran, Michelle M Hill, Colleen C Nelson
Proliferation and maintenance of both normal and prostate cancer (PCa) cells is highly regulated by steroid hormones, particularly androgens, and the extracellular environment. Herein, we identify the secretion of CD9 positive extracellular vesicles (EV) by LNCaP and DUCaP PCa cells in response to dihydrotestosterone (DHT) and use nano-LC-MS/MS to identify the proteins present in these EV. Subsequent bioinformatic and pathway analyses of the mass spectrometry data identified pathologically relevant pathways that may be altered by EV contents...
August 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28870477/a-low-protein-high-carbohydrate-diet-increases-browning-in-perirenal-adipose-tissue-but-not-in-inguinal-adipose-tissue
#12
Mayara P Pereira, Laís A A Ferreira, Flávia H S da Silva, Marcelo A Christoffolete, George S Metsios, Valéria E Chaves, Suélem A de França, Amílcar S Damazo, Andreas D Flouris, Nair H Kawashita
OBJECTIVE: The aim of this study was to evaluate the browning and origin of fatty acids (FAs) in the maintenance of triacylglycerol (TG) storage and/or as fuel for thermogenesis in perirenal adipose tissue (periWAT) and inguinal adipose tissue (ingWAT) of rats fed a low-protein, high-carbohydrate (LPHC) diet. METHODS: LPHC (6% protein, 74% carbohydrate) or control (C; 17% protein, 63% carbohydrate) diets were administered to rats for 15 d. The tissues were stained with hematoxylin and eosin for histologic analysis...
October 2017: Nutrition
https://www.readbyqxmd.com/read/28863693/kinetic-energy-offsets-for-multicharged-ions-from-an-electron-beam-ion-source
#13
D D Kulkarni, C D Ahl, A M Shore, A J Miller, J E Harriss, C E Sosolik, J P Marler
Using a retarding field analyzer, we have measured offsets between the nominal and measured kinetic energy of multicharged ions extracted from an electron beam ion source (EBIS). By varying source parameters, a shift in ion kinetic energy was attributed to the trapping potential produced by the space charge of the electron beam within the EBIS. The space charge of the electron beam depends on its charge density, which in turn depends on the amount of negative charge (electron beam current) and its velocity (electron beam energy)...
August 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/28863114/review-of-patch-testing-for-evaluation-of-hypersensitivity-to-implanted-metal-devices-a-perspective-from-the-american-contact-dermatitis-society-by-schalock-pc-crawford-g-nedorost-s-scheinman-pl-atwater-ar-mowad-c-brod-b-ehrlich-a-watsky-kl-sasseville-d-silvestri
#14
https://www.readbyqxmd.com/read/28862946/%C3%AE-1-adrenergic-receptors-function-within-hetero-oligomeric-complexes-with-atypical-chemokine-receptor-3-and-chemokine-c-x-c-motif-receptor-4-in-vascular-smooth-muscle-cells
#15
Lauren J Albee, Jonathan M Eby, Abhishek Tripathi, Heather M LaPorte, Xianlong Gao, Brian F Volkman, Vadim Gaponenko, Matthias Majetschak
BACKGROUND: Recently, we provided evidence that α1-adrenergic receptors (ARs) in vascular smooth muscle are regulated by chemokine (C-X-C motif) receptor (CXCR) 4 and atypical chemokine receptor 3 (ACKR3). While we showed that CXCR4 controls α1-ARs through formation of heteromeric receptor complexes in human vascular smooth muscle cells (hVSMCs), the molecular basis underlying cross-talk between ACKR3 and α1-ARs is unknown. METHODS AND RESULTS: We show that ACKR3 agonists inhibit inositol trisphosphate production in hVSMCs on stimulation with phenylephrine...
August 17, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28860512/regulation-of-androgen-receptor-signaling-by-ubiquitination-during-folliculogenesis-and-its-possible-dysregulation-in-polycystic-ovarian-syndrome
#16
Jung Jin Lim, Patricia D A Lima, Reza Salehi, Dong Ryul Lee, Benjamin K Tsang
Although chronic hyperandrogenism suppresses antral follicular development, a phenomenon often observed in polycystic ovarian syndrome (PCOS), whether and how deregulation of androgen receptor (AR) signaling is involved, is not well understood. In the present study, we examined the role of ring finger protein 6 (RNF6) in AR ubiquitination and the possible dysregulation in the expression and actions of growth differentiation factor 9 (GDF9) and kit-ligand (Kitlg) in a chronic androgenized PCOS rat model. 5α-dihydrotestosterone (DHT) treatment in vivo inhibited antral follicle growth, a response mediated through increased RNF6 content, suppressed K63- but increased K48-linked AR ubiquitination as well as the mRNA expression and content of soluble KIT-L (sKitlg) and content of GDF9...
August 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28854665/the-effect-of-maize-hybrid-on-biology-and-life-table-parameters-of-the-trogoderma-granarium-coleoptera-dermestidae
#17
S Majd-Marani, B Naseri, G Nouri-Ganbalani, E Borzoui
The khapra beetle, Trogoderma granarium Everts (Coleoptera: Dermestidae), is a polyphagous pest that infests many stored grains and products. The effect of nine maize hybrids including 704, AR 89, AS 71, AS 77, BC 678, KSC 703, PL 472, SC 704, and Simax was studied on biology and life table parameters of T. granarium at controlled conditions (33 ± 1 °C, 65 ± 5% RH, and a photoperiod of 14:10 [L:D] h). According to the results of this study, the immature period was the longest on BC 678 (56.79 ± SE: 1...
August 1, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/28853626/profile-of-the-illegal-import-of-products-of-animal-origin-to-brazilian-cities-at-the-border-with-argentina-and-uruguay
#18
J G Pereira, V M Soares, E A R Santos, L E Tadielo, D C P Pellegrini, E H Duval, W P Silva
International food transit is a risk to public and animal health when not subject to legal importation sanitation procedures. Due to the extensive border area, illegal food import in Brazil is a common practice, especially in Rio Grande do Sul (RS), a state that borders with Argentina and Uruguay. The objective of this study was to evaluate the profile of Brazilians living in cities in RS that border with Argentina (BR-AR) or Uruguay (BR-UR) regarding the practice of illegal import of products of animal origin and to determine associations between the population characteristics and illegal import...
August 30, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28833628/neural-androgen-receptor-overexpression-affects-cell-number-in-the-spinal-nucleus-of-the-bulbocavernosus
#19
Lindsay A Coome, Ashlyn Swift-Gallant, Firyal Ramzan, Lindsay Melhuish Beaupre, Tanya Brkic, D Ashley Monks
The spinal nucleus of the bulbocavernosus (SNB) is a sexually dimorphic neuromuscular system in which masculinization of cell number is thought to depend on perinatal androgen action in non-neural targets, but masculinization of cell size is thought to depend primarily on adult androgen action on SNB cells themselves. In order to test these hypotheses, we characterized the SNB of Cre/loxP transgenic mice that overexpress androgen receptor (AR) throughout the body (CMV-AR) or in neural tissue only (Nestin-AR)...
August 20, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/28833265/local-allergic-rhinitis-is-an-independent-rhinitis-phenotype-the-results-of-a-10-years-follow-up-study
#20
Carmen Rondon, Paloma Campo, Ibon Eguiluz Gracia, Carmen Plaza, Gador Bogas, Pedro Galindo, C Mayorga, M J Torres
BACKGROUND: The knowledge about the natural history of local allergic rhinitis (LAR) is limited. One unmeet question is to demonstrate whether LAR should be considered the first step in the development of allergic rhinitis (AR) or an independent phenotype. The aim of this study was to prospectively evaluate the natural history of a population with LAR, the potential conversion to AR with systemic atopy, and the development of asthma during 10 years. METHODS: This is the second phase of a 10 year follow-up study of a cohort of 176 patients with LAR of recent onset and 115 age- and sex-matched healthy controls prospectively evaluated from 2005 to 2016...
August 22, 2017: Allergy
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