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https://www.readbyqxmd.com/read/28722220/developing-new-targeting-strategy-for-androgen-receptor-variants-in-castration-resistant-prostate-cancer
#1
Bin Wang, U-Ging Lo, Kaijie Wu, Payal Kapur, Xiangyang Liu, Jun Huang, Wei Chen, Elizabeth Hernandez, John Santoyo, Shi-Hong Ma, Rey-Chen Pong, Dalin He, Yi-Qiang Cheng, Jer-Tsong Hsieh
The presence of androgen receptor variant 7 (AR-V7) variants becomes a significant hallmark of castration resistant prostate cancer (CRPC) relapsed from hormonal therapy and is associated with poor survival of CRPC patients because of lacking a ligand-binding domain. Currently, it still lacks an effective agent to target AR-V7 or AR-Vs in general. Here, we showed a novel class of agents (thailanstatins, TSTs, spliceostatin A analogs) can significantly suppress the expression of AR-V7 mRNA and protein but in a less extent on the full-length AR expression...
July 19, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28719817/aged-refuse-enhances-anaerobic-digestion-of-waste-activated-sludge
#2
Jianwei Zhao, Lin Gui, Qilin Wang, Yiwen Liu, Dongbo Wang, Bing-Jie Ni, Xiaoming Li, Rui Xu, Guangming Zeng, Qi Yang
In this work, a low-cost alternative approach (i.e., adding aged refuse (AR) into waste activated sludge) to significantly enhance anaerobic digestion of sludge was reported. Experimental results showed that with the addition dosage of AR increasing from 0 to 400 mg/g dry sludge soluble chemical oxygen demand (COD) increased from 1150 to 5240 mg/L at the digestion time of 5 d, while the maximal production of volatile fatty acids (VFA) increased from 82.6 to 183.9 mg COD/g volatile suspended solids. Although further increase of AR addition decreased the concentrations of both soluble COD and VFA, their contents in these systems with AR addition at any concentration investigated were still higher than those in the blank, which resulted in higher methane yields in these systems...
July 14, 2017: Water Research
https://www.readbyqxmd.com/read/28719099/spontaneous-keto-enol-tautomerization-in-the-crystal-lattice-visualized-with-the-help-of-water-encapsulated-in-hydrophilic-reservoirs
#3
Marta K Dudek, Ewelina Wielgus, Piotr Paluch, Marek Potrzebowski
Keto-enol tautomerism in the solid phase is a process that is particularly difficult to follow. In this work we demonstrate how it can be done by introducing deuterium into the crystal lattice of organic compounds, which tend to form hydrates. In our studies we explored H-D exchange in the crystals stored in contact with deuterium oxide vapors. Employing barbituric acid (BA) and (+)-catechin (CAT) as model samples, by means of advanced solid-state NMR and mass spectrometry, we revealed that not only OH and NH protons of these chemicals undergo exchange to deuterium in a crystal lattice, but also usually immobile protons, i...
July 18, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28717648/response-detection-of-castrate-resistant-prostate-cancer-to-clinically-utilised-and-novel-treatments-by-monitoring-phospholipid-metabolism
#4
Tim A D Smith, Su M Phyu, Kholoud S Alzyoud, Chih-Chung Tseng
Androgen receptor (AR) activation is the primary driving factor in prostate cancer which is initially responsive to castration but then becomes resistant (castration-resistant prostate cancer (CRPC)). CRPC cells still retain the functioning AR which can be targeted by other therapies. A recent promising development is the use of inhibitors (Epi-1) of protein-protein interaction to inhibit AR-activated signalling. Translating novel therapies into the clinic requires sensitive early response indicators. Here potential response markers are explored...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28714478/immobilization-of-single-argon-atoms-in-nano-cages-of-two-dimensional-zeolite-model-systems
#5
Jian-Qiang Zhong, Mengen Wang, Nusnin Akter, John D Kestell, Alejandro M Boscoboinik, Taejin Kim, Dario J Stacchiola, Deyu Lu, J Anibal Boscoboinik
The confinement of noble gases on nanostructured surfaces, in contrast to bulk materials, at non-cryogenic temperatures represents a formidable challenge. In this work, individual Ar atoms are trapped at 300 K in nano-cages consisting of (alumino)silicate hexagonal prisms forming a two-dimensional array on a planar surface. The trapping of Ar atoms is detected in situ using synchrotron-based ambient pressure X-ray photoelectron spectroscopy. The atoms remain in the cages upon heating to 400 K. The trapping and release of Ar is studied combining surface science methods and density functional theory calculations...
July 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/28706584/assessment-of-aortic-valve-disease-a-clinician-oriented-review
#6
REVIEW
Andrei D Mǎrgulescu
Aortic valve disease [aortic stenosis (AS) and aortic regurgitation (AR)] represents an important global health problem; when severe, aortic valve disease carries poor prognosis. For AS, aortic valve replacement, either surgical or interventional, may provide definite treatment in carefully selected patients. For AR, valve surgery (either replacement or - in selected cases - aortic valve repair) remains the gold standard of care. To properly identify those patients who are candidates for surgery, the clinician has to carefully assess the severity of valve disease with an understanding of the potential pitfalls involved in these assessments...
June 26, 2017: World Journal of Cardiology
https://www.readbyqxmd.com/read/28703870/a-bulky-m-terphenyl-cyclopentadienyl-ligand-and-its-alkali-metal-complexes-li-na-k-rb-and-cs
#7
Alex J Veinot, Angela D K Todd, Jason Masuda
The synthesis of the new m-terphenyl substituted cyclopentadienyl ligand precursor 1-cyclopentadiene-2,6-bis(2,4,6-trimethylphenyl)benzene (TerMesCpH) is described. Synthesis proceeds through the reaction of TerMesLi with cobaltocenium iodide, followed by oxidation of the intermediate cobalt(I) species to give the corresponding cyclopentadiene as a mixture of isomers. The preparation and spectroscopic properties of the alkali metal salts (Li-Cs) is described, as well as structural information obtained by X-ray diffraction studies for the lithium, potassium, and caesium analogues...
July 13, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28692125/steroid-metabolism-gene-polymorphisms-and-their-implications-on-breast-and-ovarian-cancer-prognosis
#8
E V W Dos Santos, L N R Alves, I D Louro
A role for estrogen in the etiology of breast and ovarian cancers has been suggested; therefore, genetic polymorphisms in steroid metabolism genes could be involved in the carcinogenesis of these tumors. We have aimed to investigate the role of GSTP1 and CYP17 polymorphisms and their correlation with MSI (microsatellite instability) and LOH (loss of heterozygosity) in AR, ERβ and CYP19 genes in women from Espírito Santo State, Brazil. The study population consisted of 107 female breast and 24 ovarian tumors...
July 6, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28692047/androgen-induces-g3bp2-and-sumo-mediated-p53-nuclear-export-in-prostate-cancer
#9
D Ashikari, K Takayama, T Tanaka, Y Suzuki, D Obinata, T Fujimura, T Urano, S Takahashi, S Inoue
The androgen receptor (AR) has a central role in prostate cancer progression, particularly treatment-resistance disease including castration-resistant prostate cancer. Loss of the p53 tumor suppressor, a nuclear transcription factor, is also known to contribute to prostate malignancy. Here we report that p53 is translocated to the cytoplasm by androgen-mediated induction of G3BP2, a newly described direct target gene of AR. G3BP2 induces both cell cycle progression and blocks apoptosis. Translocation of p53 is regulated by androgen-dependent sumoylation mediated by the G3BP2-interacting SUMO-E3 ligase, RanBP2...
July 10, 2017: Oncogene
https://www.readbyqxmd.com/read/28688705/density-functional-theory-study-of-adsorption-geometries-and-electronic-structures-of-azo-dye-based-molecules-on-anatase-tio2-surface-for-dye-sensitized-solar-cell-applications
#10
Pongthep Prajongtat, Songwut Suramitr, Somkiat Nokbin, Koichi Nakajima, Koichiro Mitsuke, Supa Hannongbua
Structural and electronic properties of eight isolated azo dyes (ArNNAr', where Ar and Ar' denote the aryl groups containing benzene and naphthalene skeletons, respectively) were investigated by density functional theory (DFT) based on the B3LYP/6-31G(d,p) and TD-B3LYP/6-311G(d,p) methods The effect of methanol solvent on the structural and electronic properties of the azo dyes was elucidated by employing a polarizable continuum model (PCM). Then, the azo dyes adsorbed onto the anatase TiO2 (101) slab surface through a carboxyl group...
June 11, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28687450/role-of-androgens-in-the-ovary
#11
REVIEW
K A Walters, D J Handelsman
It has been well established for decades that androgens, namely testosterone (T) plays an important role in female reproductive physiology as the precursor for oestradiol (E2). However, in the last decade a direct role for androgens, acting via the androgen receptor (AR), in female reproductive function has been confirmed. Deciphering the specific roles of androgens in ovarian function has been hindered as complete androgen resistant females cannot be generated by natural breeding. In addition, androgens can be converted into estrogens which has caused confusion when interpreting findings from pharmacological studies, as observed effects could have been mediated via the AR or estrogen receptor...
July 4, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28682871/post-hoc-analyses-of-east-asian-patients-from-the-randomized-placebo-controlled-prevail-trial-of-enzalutamide-in-patients-with-chemotherapy-na%C3%A3-ve-metastatic-castration-resistant-prostate-cancer
#12
Choung Soo Kim, Young Deuk Choi, Sang Eun Lee, Hyun Moo Lee, Takeshi Ueda, Junji Yonese, Takashi Fukagai, Edmund Chiong, Weber Lau, Sarang Abhyankar, Ad Theeuwes, Bertrand Tombal, Tomasz M Beer, Go Kimura
BACKGROUND: Enzalutamide is an androgen receptor (AR) inhibitor that acts on different steps in the AR signaling pathway. In PREVAIL, an international, phase III, double-blind, placebo-controlled trial, enzalutamide significantly reduced the risk of radiographic progression by 81% (hazard ratio [HR], 0.19; P < .0001) and reduced the risk of death by 29% (HR, 0.71; P < .0001) compared with placebo in chemotherapy-naïve men with metastatic castration-resistant prostate cancer...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28680113/oxygen-consumption-of-gastrocnemius-medialis-muscle-during-submaximal-voluntary-isometric-contractions-with-and-without-preceding-stretch
#13
F K Paternoster, D Hahn, F Stöcker, A Schwirtz, W Seiberl
After an active muscle stretch, maintaining a certain amount of force in the following isometric phase is accompanied by less muscle activation compared to an isometric contraction without preceding active stretch at the corresponding muscle length. This reduced muscle activation might be related to reduced metabolic costs, such as the oxidative metabolism. Hence, the aim of this study was to clarify if mechanisms associated with stretch-induced activation reduction (AR) also influence oxygen consumption of voluntary activated human muscles after active stretch...
July 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28676262/adaptive-response-in-mouse-bone-marrow-stromal-cells-exposed-to-900mhz-radiofrequency-fields-impact-of-poly-adp-ribose-polymerase-parp
#14
Qina He, Lin Zong, Yulong Sun, Vijayalaxmi, Thomas J Prihoda, Jian Tong, Yi Cao
This study examined whether non-ionizing radiofrequency fields (RF) exposure is capable of inducing poly (ADP-ribose) polymerase-1 (PARP-1) in bone marrow stromal cells (BMSCs) and whether it plays a role in RF-induced adaptive response (AR). Bone marrow stromal cells (BMSCs) were exposed to 900MHz RF at 120μW/cm(2) power flux density for 3h/day for 5days and then challenged with a genotoxic dose of 1.5Gy gamma-radiation (GR). Some cells were also treated with 3-aminobenzamide (3-AB, 2mM final concentration), a potent inhibitor of PARP-1...
August 2017: Mutation Research
https://www.readbyqxmd.com/read/28676237/spinal-muscular-atrophy-carriers-with-two-smn1-copies
#15
Mawaddah Ar Rochmah, Hiroyuki Awano, Tomonari Awaya, Nur Imma Fatimah Harahap, Naoya Morisada, Yoshihiro Bouike, Toshio Saito, Yuji Kubo, Kayoko Saito, Poh San Lai, Ichiro Morioka, Kazumoto Iijima, Hisahide Nishio, Masakazu Shinohara
BACKGROUND: Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disorder. Over 95% of SMA patients have homozygous deletions of the SMA-causative gene, SMN1. Thus, SMA carriers are usually diagnosed based on SMN1 copy number, with one copy indicating SMA carrier status. However, two SMN1 copies do not always exclude carrier status. In this study, we identified SMA carriers with two SMN1 copies. SUBJECTS AND METHODS: From 33 families, 65 parents of genetically confirmed SMA patients were tested to determine SMA carrier status...
July 1, 2017: Brain & Development
https://www.readbyqxmd.com/read/28673639/management-and-outcome-of-residual-aortic-regurgitation-after-transcatheter-aortic-valve-implantation
#16
Edward Koifman, Romain Didier, Hector Garcia-Garcia, Gaby Weissman, Andrew W Ertel, Sarkis Kiramijyan, Arie Steinvil, Toby Rogers, Nirav Patel, Sandeep Kumar, Arpi Tavil-Shatelyan, Itsik Ben-Dor, Augusto D Pichard, Rebecca Torguson, Jiaxiang Gai, Lowell F Satler, Ron Waksman
We aimed to evaluate the success rates of balloon valvuloplasty post-dilation (BVPD) and a second-valve deployment in reducing residual aortic regurgitation (AR) after transcatheter aortic valve implantation (TAVI) and its impact on outcome. Residual AR immediately post-TAVI in patients with aortic stenosis is a common condition that adversely affects outcome. Patients who underwent TAVI who had more-than-mild residual AR were managed either with medical therapy, re-intervention with BVPD, or a second valve...
May 31, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28671476/molecular-group-13-metallaborates-derived-from-m-o-m-cleavage-promoted-by-bh3
#17
Erandi Bernabé-Pablo, Vojtech Jancik, Diego Martínez-Otero, Joaquín Barroso-Flores, Mónica Moya-Cabrera
The reaction of metalloxanes [{(Me)LM(OH)}2(μ-O)] [M = Al (1), Ga (2); (Me)L = CH{CMe(NAr)}2(-), Ar = 2,4,6-Me3C6H2, Me = methyl] with an excess of BH3·D (D = tetrahydrofuran (THF), SMe2) affords annular metallaborate systems achieved through M-O-M cleavage. Compound 1 led exclusively to the formation of eight-membered ring systems [{(Me)LAl(μ-O){B(O(n)Bu)}(μ-O)}2] (3) and [{(Me)LAl(μ-O)(BH)(μ-O)}2] (6), while for 2 the unprecedented six-membered ring systems [{((Me)LGa)2(μ-O)}(μ-O)2{B(O(n)Bu)}] (4) and [((Me)LGa)(μ-O)2{(BO(n)Bu)2(μ-O)}] (5) were observed...
July 17, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28659719/somatic-mutation-analyses-in-studies-of-the-clonal-evolution-and-diagnostic-targets-of-prostate-cancer
#18
REVIEW
Dmitry S Mikhaylenko, Gennady D Efremov, Vladimir V Strelnikov, Dmitry V Zaletaev, Boris Y Alekseev
Prostate cancer (PC) is the most common uro-oncological disease in the global population and still requires a more efficient laboratory diagnosis. Point mutations of oncogenes and tumor sup-pressor genes are the most frequent molecular genetic events in carcinogenesis. The mutations are re-sponsible, to a great extent, for the clonal evolution of cancer and can be considered as primary candi-date molecular markers of PC. Using next-generation sequencing to analyze the mutations in PC, the main molecular PC subtypes were identified, which depended on the presence of fusion genes and FOXA1, CHD1, and SPOP point mutations; other driver mutations responsible for the progression of PC subclones were also characterized...
June 2017: Current Genomics
https://www.readbyqxmd.com/read/28659002/in-vitro-and-in-vivo-antidiabetic-potential-of-extracts-and-a-furostanol-saponin-from-balanites-aegyptiaca
#19
Shahira Mohammed Ezzat, Amira Abdel Motaal, Sally Abdel Wanees El Awdan
CONTEXT: Balanites aegyptiaca Del. (Zygophyllaceae) fruits are well-known antidiabetic drug in Egyptian folk medicine. Nevertheless, its mechanism of action is still unclear. OBJECTIVES: Searching for the possible mechanisms of action of the plant and identification of its bioactive compounds. MATERIALS AND METHODS: A bio-guided protocol based on the evaluation of α-glucosidase (AG) and aldose reductase (AR) inhibitory activities was adopted to isolate the biologically active compounds from the methanol extract (MeEx)...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28656103/the-effect-of-the-degree-of-astigmatism-on-optical-quality-in-children
#20
Jing Gao, Xiao-Xia Wang, Lin Wang, Yuan Sun, Rui-Fen Liu, Qi Zhao
PURPOSE: To investigate the effect of the degree of astigmatism on optical quality in children. The important objective evaluation parameters we focus on include the RMS of the high-order aberrations, MTF, and PSF. METHODS: The children, age ranging from 7 to 10 years old, underwent an optometry examination. Fifty-nine children who met the inclusion criteria were divided into three groups: A (1.0 D ≤ astigmatism < 2.0 D), B (2.0 D ≤ astigmatism < 3...
2017: Journal of Ophthalmology
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