keyword
MENU ▼
Read by QxMD icon Read
search

Spirochete

keyword
https://www.readbyqxmd.com/read/29664394/dynamics-of-spirochetemia-and-early-pcr-detection-of-borrelia-miyamotoi
#1
Lyudmila Karan, Marat Makenov, Nadezhda Kolyasnikova, Olga Stukolova, Marina Toporkova, Olga Olenkova
We investigated whether Borrelia miyamotoi disease can be detected in its early stage by using PCR for borrelial 16S rRNA, which molecule (DNA or RNA) is the best choice for this test, and whether spirochetes are present in blood during the acute phase of B. miyamotoi disease. A total of 473 patients with a suspected tickborne infection in Yekaterinburg, Russia, in 2009, 2010, and 2015 were enrolled in this study. Blood samples were analyzed by using quantitative PCR or ELISA, and a diagnosis of borreliosis was confirmed for 310 patients...
May 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29662016/persistent-borrelia-infection-in-patients-with-ongoing-symptoms-of-lyme-disease
#2
Marianne J Middelveen, Eva Sapi, Jennie Burke, Katherine R Filush, Agustin Franco, Melissa C Fesler, Raphael B Stricker
INTRODUCTION: Lyme disease is a tickborne illness that generates controversy among medical providers and researchers. One of the key topics of debate is the existence of persistent infection with the Lyme spirochete, Borrelia burgdorferi , in patients who have been treated with recommended doses of antibiotics yet remain symptomatic. Persistent spirochetal infection despite antibiotic therapy has recently been demonstrated in non-human primates. We present evidence of persistent Borrelia infection despite antibiotic therapy in patients with ongoing Lyme disease symptoms...
April 14, 2018: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/29661882/-in-vitro-antimicrobial-susceptibility-of-clinical-isolates-of-borrelia-miyamotoi
#3
Joris Koetsveld, Annemijn Manger, Dieuwertje Hoornstra, Ronald O Draga, Anneke Oei, Nadezhda M Kolyasnikova, Marina G Toporkova, Denis S Sarksyan, Alex Wagemakers, Alexander E Platonov, Joppe W Hovius
Objectives : Borrelia miyamotoi is an emerging relapsing fever (RF) Borrelia species that is described to cause human disease in regions where Lyme borreliosis is endemic. We have recently shown that B. miyamotoi tick isolates are resistant to amoxicillin in vitro, however, clinical isolates have not been studied. Therefore, our aim was to show antimicrobial susceptibility of recently obtained clinical isolates of B. miyamotoi Methods : A dilution series of various antibiotics was made in MKP-F media. Susceptibility of different clinical B...
April 16, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29623212/first-report-of-lyme-disease-in-nepal
#4
Sher Bahadur Pun, Sumit Agrawal, Santoshananda Jha, Lila Nath Bhandari, Bimal Sharma Chalise, Abadhesh Mishra, Rajesh Shah
Introduction: Lyme disease is a tick-borne illness caused by the spirochete Borrelia burgdorferi and is widely reported in the USA, Central Europe, South East Asia and Latin America. Until recently, no scientific report regarding Lyme disease in Nepal had been published. Case presentation: A 32-year-old, previously healthy female visited the hospital with a history of joint pains, fatigue, neck stiffness, tingling sensation and headache. She was initially treated for typhoid fever, brucellosis and malaria, but did not show significant improvement...
March 2018: JMM Case Reports
https://www.readbyqxmd.com/read/29621350/infection-history-of-the-blood-meal-host-dictates-pathogenic-potential-of-the-lyme-disease-spirochete-within-the-feeding-tick-vector
#5
Bharti Bhatia, Chad Hillman, Valentina Carracoi, Britney N Cheff, Kit Tilly, Patricia A Rosa
Lyme disease in humans is caused by several genospecies of the Borrelia burgdorferi sensu lato (s.l.) complex of spirochetal bacteria, including B. burgdorferi, B. afzelii and B. garinii. These bacteria exist in nature as obligate parasites in an enzootic cycle between small vertebrate hosts and Ixodid tick vectors, with humans representing incidental hosts. During the natural enzootic cycle, infected ticks in endemic areas feed not only upon naïve hosts, but also upon seropositive infected hosts. In the current study, we considered this environmental parameter and assessed the impact of the immune status of the blood-meal host on the phenotype of the Lyme disease spirochete within the tick vector...
April 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29610317/plasticity-in-early-immune-evasion-strategies-of-a-bacterial-pathogen
#6
Quentin Bernard, Alexis A Smith, Xiuli Yang, Juraj Koci, Shelby D Foor, Sarah D Cramer, Xuran Zhuang, Jennifer E Dwyer, Yi-Pin Lin, Emmanuel F Mongodin, Adriana Marques, John M Leong, Juan Anguita, Utpal Pal
Borrelia burgdorferi is one of the few extracellular pathogens capable of establishing persistent infection in mammals. The mechanisms that sustain long-term survival of this bacterium are largely unknown. Here we report a unique innate immune evasion strategy of B. burgdorferi , orchestrated by a surface protein annotated as BBA57, through its modulation of multiple spirochete virulent determinants. BBA57 function is critical for early infection but largely redundant for later stages of spirochetal persistence, either in mammals or in ticks...
April 2, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29606622/factors-responsible-for-ixodes-ricinus-nymph-abundance-are-soil-features-indicators-of-tick-abundance-in-a-french-region-where-lyme-borreliosis-is-endemic
#7
Valérie Goldstein, Nathalie Boulanger, Dominique Schwartz, Jean-Claude George, Damien Ertlen, Laurence Zilliox, Mickaël Schaeffer, Benoît Jaulhac
In Europe, the hard tick Ixodes ricinus (Acari: Ixodidae) is the main vector of Lyme borreliosis spirochetes (Borrelia burgdorferi sensu lato group). A field study was conducted to evaluate the abundance of Ixodes nymphs in the French region of Alsace, where Lyme borreliosis is endemic, and to determine whether environmental factors such as soil moisture and composition may be associated with nymph abundance. In the ten sites studied, ticks were collected by drag sampling from March to October in 2013 and 2014...
March 26, 2018: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29575881/prevalence-of-i-borrelia-burgdorferi-i-in-ticks-removed-from-skin-of-people-and-circumstances-of-being-bitten-research-from-the-area-of-poland-2012-2014
#8
Edyta Gałęziowska, Jolanta Rzymowska, Nella Najda, Przemysław Kołodziej, Renata Domżał-Drzewicka, Marcin Rząca, Bożena Muraczyńska, Marianna Charzyńska-Gula, Zdzisława Szadowska-Szlachetka, Barbara Ślusarska, Edyta Guty
INTRODUCTION: During feeding, the tick sucks blood from the host along with the pathogens that are in the blood, simultaneously exchanging its own pathogens with the host. Humans can also be a host. It is important to understand the most typical circumstances in which people might become infected with<i> Borrelia burgdorferi</i>. This knowledge will help to prepare health education programmes aimed at the prevention of Lyme disease and other tick-borne diseases. OBJECTIVE: The aim of the study was to determine the percentage of ticks infected with <i>Borrelia burgdorferi</i> sensu lato, depending on the circumstances of getting bitten...
March 14, 2018: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/29571703/isolation-and-molecular-characterization-of-a-relapsing-fever-borrelia-recovered-from-ornithodoros-rudis-in-brazil
#9
Sebastián Muñoz-Leal, Álvaro A Faccini-Martínez, Francisco B Costa, Arlei Marcili, Eric T K C Mesquita, Edwaldo P Marques, Marcelo B Labruna
In South America, early reports from more than 50 years ago incriminated Ornithodoros rudis as vector of Borrelia venezuelensis, an agent of tick-borne relapsing fever (TBRF). Herein we report the rediscovery of O. rudis by means of morphological, biological and molecular analyses, which also comprise the first report of this tick species in Brazil. Phylogenetic analysis using partial fragments of mitochondrial 16S rRNA gene suggested that O. rudis forms a monophyletic group with Ornithodoros erraticus. By using laboratory rodents as hosts, we isolated a relapsing fever Borrelia from an infected O...
March 9, 2018: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29569269/detection-of-borrelia-in-ixodes-scapularis-ticks-by-silver-stain-immunohistochemical-and-direct-immunofluorescent-methods
#10
Anjela Galan, Paul Kupernik, Shawn E Cowper
BACKGROUND: Lyme disease (LD) is one of the most common tick-borne diseases caused by several Borrelia species of spirochetes. Ixodes scapularis is responsible for the transmission of LD in the northeastern United States. The rate of infection varies with the duration of tick attachment to the host, however this information may be unknown. In skin biopsies it is often difficult to identify spirochetes. Testing of ticks is not routinely performed. Treatment is established by clinical presentation...
March 22, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29554975/first-detection-of-borrelia-miyamotoi-in-ixodes-ricinus-ticks-from-northern-italy
#11
Silvia Ravagnan, Laura Tomassone, Fabrizio Montarsi, Aleksandra Iwona Krawczyk, Eleonora Mastrorilli, Hein Sprong, Adelaide Milani, Luca Rossi, Gioia Capelli
BACKGROUND: Borrelia miyamotoi is a spirochete transmitted by several ixodid tick species. It causes a relapsing fever in humans and is currently considered as an emerging pathogen. In Europe, B. miyamotoi seems to occur at low prevalence in Ixodes ricinus ticks but has a wide distribution. Here we report the first detection of B. miyamotoi in Ixodes ricinus ticks collected in two independent studies conducted in 2016 in the north-eastern and north-western Alps, Italy. RESULTS: Three out of 405 nymphs (0...
March 20, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29543607/ce-lyme-disease-diagnosis-treatment-and-prevention
#12
Susan Kane Patton, Bailey Phillips
Evidence-based strategies for nurses. ABSTRACT: Lyme disease is recognized as the most common vector-borne disease in the United States. Surveillance data indicate both increasing numbers of Lyme disease cases and geographic expansion of areas where the causative spirochete, Borrelia burgdorferi, can be found. With prompt diagnosis and appropriate treatment in the acute stage, most patients will recover fully. Without treatment, however, the infecting pathogen remains within the body, often producing long-term complications, including musculoskeletal, neurologic, and cardiovascular effects...
March 14, 2018: American Journal of Nursing
https://www.readbyqxmd.com/read/29534300/adaptation-of-borrelia-burgdorferi-to-its-natural-hosts-by-synonymous-codon-and-amino-acid-usage
#13
Xiao-Xia Ma, Peng Ma, Qiu-Yan Chang, Zhen-Bin Liu, Derong Zhang, Xiao-Kai Zhou, Zhong-Ren Ma, Xin Cao
Lyme disease, caused by Borrelia burgdorferi, is a focally endemic tick-transmitted zoonotic infection. In this study, the major factors underlying synonymous codon-related amino acid usage in the B. burgdorferi genome and bias in synonymous codon usage of the translation initiation region of coding sequences were analyzed. Additionally, adaptation of B. burgdorferi to several of its hosts was analyzed in the context of synonymous codon usage. Principal component analysis (PCA) revealed that nucleotide content at the third synonymous position of a codon influenced the synonymous codon usage pattern, but the strand-specific factor did not influence the synonymous codon usage pattern of B...
March 13, 2018: Journal of Basic Microbiology
https://www.readbyqxmd.com/read/29529330/overview-of-laboratory-methods-to-diagnose-leptospirosis-and-to-identify-and-to-type-leptospires
#14
REVIEW
Aurélie Marquez, Zoheira Djelouadji, Virginie Lattard, Angéli Kodjo
Leptospirosis is a virulent zoonosis with a global distribution. Pathogenic spirochetes of the genus Leptospira are responsible for this disease, and the primary animal reservoirs are rodentvvvs. Direct and indirect contact with infected urine constitutes the main route of transmission. Renal failure and advanced abortions are frequently observed in animals affected by leptospirosis, causing serious problems for farms. In humans, there is a high rate of mortality (10 percent), and farmers and persons in contact with water are frequently exposed...
December 2017: International Microbiology: the Official Journal of the Spanish Society for Microbiology
https://www.readbyqxmd.com/read/29528992/syphilis-vaccine-development-requirements-challenges-and-opportunities
#15
Caroline E Cameron
Syphilis, caused by the spirochete Treponema pallidum subspecies pallidum, continues to be a prevalent disease in low- and middle-income countries, and has re-emerged in key populations, including men who have sex with men, in high-income nations. The rising number of cases shows syphilis elimination will require augmentation of public health screening and treatment campaigns with syphilis vaccine development and implementation initiatives. Optimal vaccine candidates, deciphered from careful consideration of the pathogenic mechanisms employed by T...
March 9, 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29521212/linking-antimicrobial-potential-of-natural-products-derived-from-aquatic-organisms-and-microbes-involved-in-alzheimer-s-disease-a-review
#16
Dejan Stojkovic, Marina Kostic, Marija Smiljkovic, Milena Aleksic, Perica Vasiljevic, Milos Nikolic, Marina Sokovic
The following review is oriented towards microbes linked to Alzheimer's disease (AD) and antimicrobial effect of compounds and extracts derived from aquatic organisms against specific bacteria, fungi and viruses which were found previously in patients suffering from AD. Major group of microbes linked to AD include bacteria: Chlamydia pneumoniae, Helicobacter pylori, Porphyromonas gingivalis, Fusobacterium nucleatum, Prevotella intermedia, Actinomyces naeslundii, spirochete group; fungi: Candida sp., Cryptococcus sp...
March 8, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29511161/a-multi-omic-analysis-reveals-the-regulatory-role-of-cd180-during-the-response-of-macrophages-to-borrelia-burgdorferi
#17
Ana Carreras-González, Nicolás Navasa, Itziar Martín-Ruiz, José Luis Lavín, Mikel Azkargorta, Estíbaliz Atondo, Diego Barriales, Nuria Macías-Cámara, Miguel Angel Pascual-Itoiz, Leticia Sampedro, Julen Tomás-Cortázar, Ainize Peña-Cearra, Aize Pellón, Rafael Prados-Rosales, Leticia Abecia, Félix Elortza, Ana M Aransay, Héctor Rodríguez, Juan Anguita
Macrophages are cells of the innate immune system with the ability to phagocytose and induce a global pattern of responses that depend on several signaling pathways. We have determined the biosignature of murine bone marrow-derived macrophages and human blood monocytes using transcriptomic and proteomic approaches. We identified a common pattern of genes that are transcriptionally regulated and overall indicate that the response to B. burgdorferi involves the interaction of spirochetal antigens with several inflammatory pathways corresponding to primary (triggered by pattern-recognition receptors) and secondary (induced by proinflammatory cytokines) responses...
March 7, 2018: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29505766/a-case-of-syphilitic-hepatitis-in-an-hiv-infected-patient
#18
Margarita N German, Kristina A Matkowskyj, Robert J Hoffman, Parul D Agarwal
While the incidence of syphilis has been persistently on the rise in the United States, hepatitis as a complication of early syphilis is relatively uncommon. We present a case of a 51-year-old homosexual, HIV-positive male who presented with acute cholestatic hepatitis with a predominantly elevated alkaline phosphatase. After lab studies and imaging were unrevealing, a liver biopsy was performed that showed expanded portal tracts with a predominantly lymphoplasmacytic infiltrate and prominent bile ductular proliferation with periductal neutrophils...
March 2, 2018: Human Pathology
https://www.readbyqxmd.com/read/29502989/subclinical-lyme-borreliosis-is-common-in-south-eastern-sweden-and-may-be-distinguished-from-lyme-neuroborreliosis-by-sex-age-and-specific-immune-marker-patterns
#19
Hanna Carlsson, Christina Ekerfelt, Anna J Henningsson, Lars Brudin, Ivar Tjernberg
BACKGROUND: Determinants of a subclinical course of Lyme borreliosis (LB) remain largely unknown. The aim of this study was to assess the extent, sex and age profiles of subclinical Borrelia seroconversion in a LB endemic area in Sweden and to map blood cellular Borrelia-specific immune marker patterns in individuals with a previous subclinical LB course compared with patients previously diagnosed with Lyme neuroborreliosis (LNB). METHODS: A large group of 1113 healthy blood donors was screened for multiple IgG anti-Borrelia antibodies and asked to complete a health inquiry regarding previous LB...
February 16, 2018: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29498487/plasminogen-binding-and-degradation-by-treponema-denticola-identification-of-the-plasminogen-binding-interface-on-the-fhbb-protein
#20
Brittney K Tegels, Lee D Oliver, Daniel P Miller, Richard T Marconi
Treponema denticola is a proteolytic-anaerobic spirochete whose abundance in the subgingival crevice correlates with periodontal disease severity. Treponema denticola evades serum-mediated killing through the binding of factor H (FH), a negative regulator of the complement system. The T. denticola FH receptor has been identified as FhbB, an 11.4 kDa immunodominant lipoprotein. Three distinct subfamilies of FhbB proteins have been delineated and designated as FhbB1, FhbB2 and FhbB3. In this study we demonstrate that all FhbB variants bind human plasminogen (Plg)...
March 2, 2018: Molecular Oral Microbiology
keyword
keyword
111073
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"