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https://www.readbyqxmd.com/read/29449793/clinical-proteomic-analysis-of-scrub-typhus-infection
#1
Edmond Changkyun Park, Sang-Yeop Lee, Sung Ho Yun, Chi-Won Choi, Hayoung Lee, Hyun Seok Song, Sangmi Jun, Gun-Hwa Kim, Chang-Seop Lee, Seung Il Kim
Background: Scrub typhus is an acute and febrile infectious disease caused by the Gram-negative α-proteobacterium Orientia tsutsugamushi from the family Rickettsiaceae that is widely distributed in Northern, Southern and Eastern Asia. In the present study, we analysed the serum proteome of scrub typhus patients to investigate specific clinical protein patterns in an attempt to explain pathophysiology and discover potential biomarkers of infection. Methods: Serum samples were collected from three patients (before and after treatment with antibiotics) and three healthy subjects...
2018: Clinical Proteomics
https://www.readbyqxmd.com/read/29445718/designing-and-developing-automatic-trolley-for-washing-and-dressing-the-wounds
#2
M S Golvardi Yazdi, M Naderizadeh, R Afzalipour, H A Abedi, M Radmehr, R Golvardi Yazdi, Sh Salari Pashaghi
Introduction: Many items are needed for dressing including sterile dressing set, antiseptic and washing solutions, leucoplast tape, waste bin for infectious garbage, waste bin for noninfectious garbage, safe disposal trash for sharp cutting instruments, bedpan and sometimes drugs. All the items are laid out on a simple wheeled trolley. The multiplicity of items together with problems in placing tools on trolley, forgetting some items, disturbing sterile condition, falling and damaging equipment and the need for at least two people for each procedure, all are the reasons to design and develop Automatic Trolley for Washing and Dressing the Wounds...
December 2017: Journal of Biomedical Physics & Engineering
https://www.readbyqxmd.com/read/29431689/dysregulated-th1-immune-and-vascular-responses-in-scrub-typhus-pathogenesis
#3
REVIEW
Lynn Soong
Scrub typhus is an emerging, insect-transmitted disease caused by Orientia tsutsugamushi, a Gram- and LPS-negative bacterium that replicates freely within professional phagocytes and endothelial cells. Scrub typhus is prevalent with high mortality rates, but information regarding its molecular pathogenesis, microbial virulence determinants, and key immune responses is limited. Improved animal models have recently been developed that respectively resemble the pathological features of self-limiting or severe scrub typhus in humans...
February 15, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29430404/spectrum-of-cardiac-manifestations-and-its-relationship-to-outcomes-in-patients-admitted-with-scrub-typhus-infection
#4
Gunasekaran Karthik, Thomas Isaiah Sudarsan, John Victor Peter, Thambu Sudarsanam, George M Varghese, Paul Kundavaram, Sowmya Sathyendra, Ramya Iyyadurai, Kishore Pichamuthu
AIM: To study the spectrum of cardiac manifestations in scrub typhus infection and assess its relationship to outcomes. METHODS: Demographic data, electrocardiographic (ECG) changes, left ventricular (LV) systolic and diastolic function, myocardial injury (defined as troponin T > 14 pg/mL), and pericardial effusion were documented. Myocarditis was diagnosed when myocardial injury was associated with global LV systolic dysfunction. The relationship between myocarditis and outcomes was assessed using logistic regression analysis and expressed as odds ratio (OR) with 95%CI...
February 4, 2018: World Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29429641/influence-of-the-seasonal-variation-of-environmental-conditions-on-biogas-upgrading-in-an-outdoors-pilot-scale-high-rate-algal-pond
#5
David Marín, Esther Posadas, Patricia Cano, Víctor Pérez, Raquel Lebrero, Raúl Muñoz
The influence of the daily and seasonal variations of environmental conditions on the quality of the upgraded biogas was evaluated in an outdoors pilot scale high rate algal pond (HRAP) interconnected to an external absorption column (AC) via a conical settler. The high alkalinity in the cultivation broth resulted in a constant biomethane composition during the day regardless of the monitored month, while the high algal-bacterial activity during spring and summer boosted a superior biomethane quality. CO2 concentrations in the upgraded biogas ranged from 0...
February 2, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29406814/a-randomized-controlled-trial-of-video-education-versus-skill-demonstration-which-is-more-effective-in-teaching-sterile-surgical-technique
#6
Stephanie N Pilieci, Saad Y Salim, Daithi S Heffernan, Kamal M F Itani, Rachel G Khadaroo
BACKGROUND: Video education has many advantages over traditional education including efficiency, convenience, and individualized learning. Learning sterile surgical technique (SST) is imperative for medical students, because proper technique helps prevent surgical site infections (SSIs). We hypothesize that video education is at least as effective as traditional skill demonstration in teaching first-year medical students SST. METHODS: A video series was created to demonstrate SST ( https://www...
February 6, 2018: Surgical Infections
https://www.readbyqxmd.com/read/29405137/spectrum-of-infections-in-acute-febrile-illness-in-central-india
#7
Yogendra Pandurang Shelke, Vijayshri Suresh Deotale, Deepashri Laxmanrao Maraskolhe
INTRODUCTION: Infectious agent when enters in the host results in febrile illness. This may lead to increase in morbidity or even mortality in undiagnosed/untreated cases. There are many aetiological agents which lead to acute febrile illness. Among these aetiological agents, important is bacterial or viral aetiology. OBJECTIVE: The objective of this study is: (i) To know the aetiological agents responsible for acute undifferentiated febrile illness (AUFI) by serological test or by bacterial culture and (ii) To know the clinical profile of AUFI...
October 2017: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29397018/from-somda-to-application-integration-strategies-in-the-or-net-demonstration-sites
#8
Max Rockstroh, Stefan Franke, Raluca Dees, Angela Merzweiler, Gerd Schneider, Max Dingler, Christian Dietz, Jonas Pfeifer, Franziska Kühn, Malte Schmitz, Alexander Mildner, Armin Janß, Jasmin Dell'Anna Pudlik, Marcus Köny, Björn Andersen, Björn Bergh, Thomas Neumuth
The effective development and dissemination of the open integration for the next generation of operating rooms require a comprehensive testing environment. In this paper, we present the various challenges to be addressed in demonstration applications, and we discuss the implementation approach, the foci of the demonstration sites and the evaluation efforts. Overall, the demonstrator setups have proven the feasibility of the service-oriented medical device architecture (SOMDA) and real-time approaches with a large variety of example applications...
February 3, 2018: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/29396933/comparison-of-scrub-typhus-meningitis-with-acute-bacterial-meningitis-and-tuberculous-meningitis
#9
Svas Raju Kakarlapudi, Anila Chacko, Prasanna Samuel, Valsan Philip Verghese, Winsley Rose
OBJECTIVE: To compare scrub typhus meningitis with bacterial and tuberculous meningitis. METHODS: Children aged <15 years admitted with meningitis were screened and those who fit criteria for diagnosis of scrub typhus meningitis (n=48), bacterial meningitis (n=44) and tuberculous meningitis (n=31) were included for analysis. Clinical features, investigations and outcomes were compared between the three types of meningitis. RESULTS: Mean age, duration of fever at presentation, presence of headache and, altered sensorium and presence of hepatomegaly/splenomegaly were statistically significantly different between the groups...
January 15, 2018: Indian Pediatrics
https://www.readbyqxmd.com/read/29396931/scrub-typhus-meningitis-versus-acute-bacterial-meningitis-and-tuberculous-meningitis
#10
Stalin Viswanathan
No abstract text is available yet for this article.
January 15, 2018: Indian Pediatrics
https://www.readbyqxmd.com/read/29386235/an-update-on-host-pathogen-interplay-and-modulation-of-immune-responses-during-orientia-tsutsugamushi-infection
#11
REVIEW
Fabián E Díaz, Katia Abarca, Alexis M Kalergis
The obligate intracellular bacterium Orientia tsutsugamushi is the causative agent of scrub typhus in humans, a serious mite-borne disease present in a widespread area of endemicity, which affects an estimated 1 million people every year. This disease may exhibit a broad range of presentations, ranging from asymptomatic to fatal conditions, with the latter being due to disseminated endothelial infection and organ injury. Unique characteristics of the biology and host-pathogen interactions of O. tsutsugamushi , including the high antigenic diversity among strains and the highly variable, short-lived memory responses developed by the host, underlie difficulties faced in the pursuit of an effective vaccine, which is an imperative need...
April 2018: Clinical Microbiology Reviews
https://www.readbyqxmd.com/read/29385256/implementing-a-cardiac-skills-orientation-and-simulation-program
#12
Maureen W Hemingway, Patrice Osgood, Mildred Mannion
Patients with cardiac morbidities admitted for cardiac surgical procedures require perioperative nurses with a high level of complex nursing skills. Orienting new cardiac team members takes commitment and perseverance in light of variable staffing levels, high-acuity patient populations, an active cardiac surgical schedule, and the unpredictability of scheduling patients undergoing cardiac transplantation. At an academic medical center in Boston, these issues presented opportunities to orient new staff members to the scrub person role, but hampered efforts to provide active learning opportunities in a safe environment...
February 2018: AORN Journal
https://www.readbyqxmd.com/read/29374896/-epidemiology-of-scrub-typhus-and-influencing-factors-in-yunnan-province-2006-2013
#13
Y Sun, C Shi, X L Li, L Q Fang, W C Cao
Objective: To understand the epidemiological characteristics of scrub typhus and influencing factors in Yunnan province, and provide further information for the prevention and control of scrub typhus. Methods: Based on the incidence data of scrub typhus reported in Yunnan from 2006 to 2013, the epidemiological characteristics of scrub typhus were analyzed and related environmental factors were identified with panel negative binomial regression model. Results: A total of 8 980 scrub typhus cases were reported during 2006-2013 in Yunnan...
January 10, 2018: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/29370684/epidemiologic-characteristics-of-scrub-typhus-on-jeju-island
#14
Jong-Myon Bae
No abstract text is available yet for this article.
December 26, 2017: Epidemiology and Health
https://www.readbyqxmd.com/read/29368508/thermal-stability-of-particle-phase-monoethanolamine-salts
#15
Xiaolong Fan, Joseph Dawson, Min-Dong Chen, Chong Qiu, Alexei Khalizov
The use of monoethanolamine (MEA, 2-hydroxyethanamine) for scrubbing of carbon dioxide from combustion flue gases may become the dominant technology for carbon capture in the near future. The widespread implementation of this technology will result in elevated emissions of MEA to the environment that may increase the loading and modify the properties of atmospheric aerosols. We have utilized experimental measurements together with aerosol microphysics calculations to derive thermodynamic properties of several MEA salts, potentially the dominant forms of MEA in atmospheric particles...
January 25, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29368107/predictors-of-severity-in-pediatric-scrub-typhus
#16
Dinesh Kumar Narayanasamy, Thirunavukkarasu Arun Babu, Vijayasankar Vijayadevagaran, Devi Kittu, Shanthi Ananthakrishnan
OBJECTIVE: To identify the factors that can predict the severity of scrub typhus in children. METHODS: This prospective study was conducted at a tertiary care teaching hospital between November 2014 to October 2016. All children <12y of age admitted with fever for more than 7d and positive IgM ELISA for scrub typhus were included in the study. These children were followed during the hospital course and their laboratory results, response to treatment and complications were documented...
January 24, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29358295/orientia-tsutsugamushi-is-highly-susceptible-to-the-rna-polymerase-switch-region-inhibitor-corallopyronin-a-in-vitro-and-in-vivo
#17
Fredericke Kock, Matthias Hauptmann, Anke Osterloh, Till F Schäberle, Sven Poppert, Hagen Frickmann, Klaus-Dieter Menzel, Gundela Peschel, Kenneth Pfarr, Andrea Schiefer, Gabriele M König, Achim Hoerauf, Bernhard Fleischer, Christian Keller
Scrub typhus is a potentially lethal infection caused by the obligate intracellular bacterium Orientia (O.) tsutsugamushi Reports on the emergence of doxycycline-resistant strains highlight the urgent need to develop novel anti-infectives against scrub typhus.Corallopyronin A (CorA) is a novel α-pyrone compound synthesized by the myxobacterium Corallococcus coralloides and was characterized as a non-competitive inhibitor of the "switch region" of bacterial RNA polymerase (RNAP). We investigated the antimicrobial action of CorA against the human-pathogenic Karp strain of O...
January 22, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29352453/measuring-surgical-safety-during-minimally-invasive-surgical-procedures-a-validation-study
#18
Mathijs D Blikkendaal, Sara R C Driessen, Sharon P Rodrigues, Johann P T Rhemrev, Maddy J G H Smeets, Jenny Dankelman, John J van den Dobbelsteen, Frank Willem Jansen
BACKGROUND: During the implementation of new interventions (i.e., surgical devices and technologies) in the operating room, surgical safety might be compromised. Current safety measures are insufficient in detecting safety hazards during this process. The aim of the study was to observe whether surgical teams are capable of measuring surgical safety, especially with regard to the introduction of new interventions. METHODS: A Surgical Safety Questionnaire was developed that had to be filled out directly postoperative by three surgical team members...
January 19, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29350608/acute-transverse-myelitis-following-scrub-typhus-a-case-report-and-review-of-the-literature
#19
Hyun-Seung Ryu, Bong Ju Moon, Jae-Young Park, Sang-Deok Kim, Seung-Kwon Seo, Jung-Kil Lee
Context Scrub typhus is an acute febrile disease caused by Orientia tsutsugamushi. The disease can usually involve the lungs, heart, liver, spleen and brain through hematogenous dissemination. However, very rarely, acute transverse myelitis in the spinal cord develops from scrub typhus. We present a case of acute transverse myelitis following scrub typhus with a review of the literature. Findings A 66-year-old male visited a hospital for general myalgia, mild headache, and fever in October. He was noted to have thick, black papule skin on his abdomen, which was highly suggestive of scrub typhus...
January 19, 2018: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29350148/scrub-typhus-outbreak-in-chonburi-province-central-thailand-2013
#20
Wuttikon Rodkvamtook, Narupon Kuttasingkee, Piyada Linsuwanon, Yutthapong Sudsawat, Allen L Richards, Maneerat Somsri, Noppadon Sangjun, Chien-Chung Chao, Silas Davidson, Elizabeth Wanja, Jariyanart Gaywee
Investigation of a scrub typhus outbreak in Thailand during September 2013 found that 9.1% of Thai soldiers and 11.1% of residents living in areas surrounding training sites had antibodies against the causative agent, Orientia tsutsugamushi. Sequence analysis of O. tsutsugamushi from rodents and chiggers identified 7 genogroups and 3 genotypes.
February 2018: Emerging Infectious Diseases
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