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macrophagic activation syndrome

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https://www.readbyqxmd.com/read/29454748/fatty-acid-binding-protein-4-fabp4-overexpression-in-intratumoral-hepatic-stellate-cells-within-hepatocellular-carcinoma-with-metabolic-risk-factors
#1
Norimichi Chiyonobu, Shu Shimada, Yoshimitsu Akiyama, Kaoru Mogushi, Michiko Itoh, Keiichi Akahoshi, Satoshi Matsumura, Kosuke Ogawa, Hiroaki Ono, Yusuke Mitsunori, Daisuke Ban, Atsushi Kudo, Shigeki Arii, Takayoshi Suganami, Shoji Yamaoka, Yoshihiro Ogawa, Minoru Tanabe, Shinji Tanaka
Metabolic syndrome is a newly identified risk factor for hepatocellular carcinoma (HCC); however, tumor-specific biomarkers still remain unclear. We performed cross-species analysis to compare gene signatures of HCC from human patients and melanocortin 4 receptor-knockout (MC4R-KO) mice, which develop HCC with obesity, insulin resistance, and dyslipidemia. Unsupervised hierarchical clustering and principle component analysis of 746 differentially expressed orthologous genes classified HCC of 152 human patients and MC4R-KO mice into two distinct subgroups, one of which included mouse HCC and was etiologically associated with metabolic risk factors...
February 15, 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/29451069/arthritis-and-use-of-hydroxychloroquine-associated-with-a-decreased-risk-of-macrophage-activation-syndrome-among-adult-patients-hospitalized-with-systemic-lupus-erythematosus
#2
E M Cohen, K D'Silva, D Kreps, M B Son, K H Costenbader
Background Macrophage activation syndrome (MAS) is an uncommon but serious complication of systemic lupus erythematosus (SLE). We aimed to identify factors associated with MAS among adult hospitalized SLE patients. Methods Within the Brigham and Women's Hospital (BWH) Lupus Center Registry, we identified adult SLE patients > age 17 who had been hospitalized from 1970 to 2016, with either ferritin > 5000 ng/ml during admission or "macrophage activation syndrome" or "MAS" in discharge summary...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29447138/inflammation-in-the-pathophysiology-of-neuropathic-pain
#3
Claudia Sommer, Mathias Leinders, Nurcan Üçeyler
Peripheral nerve injuries and diseases often lead to pain persisting beyond the resolution of damage, indicating an active disease-promoting process, which may result in chronic pain. This is regarded as a maladaptive mechanism resulting from neuroinflammation that originally serves to promote regeneration and healing. Knowledge on these physiological and pathophysiological processes has accumulated over the last few decades and has started to yield potential therapeutic targets. Key players are macrophages, T-lymphocytes, cytokines, and chemokines...
March 2018: Pain
https://www.readbyqxmd.com/read/29442228/effect-of-an-88-amino-acid-deletion-in-nsp2-of-porcine-reproductive-and-respiratory-syndrome-virus-on-virus-replication-and-cytokine-responses-in-vitro
#4
Wei He, Ying Wei, Jing Yao, Xin Xie, Jiabin Huang, Siyuan Lin, Kang Ouyang, Ying Chen, Weijian Huang, Zuzhang Wei
Previously, a spontaneous 88-amino-acid (aa) deletion in nsp2 was associated with cell-adaptation of porcine reproductive and respiratory syndrome virus (PRRSV) strain JXM100, which arose during passaging of the highly pathogenic PRRSV (HP-PRRSV) strain JX143 in MARC-145 cells. Here, to elucidate the biological role of this deletion, we specifically deleted the region of a cDNA clone of HP-PRRSV strain JX143 (pJX143) corresponding to these 88 amino acids. The effect of the deletion on virus replication in cultured cells and transcriptional activation of inflammatory cytokines and chemokines in pulmonary alveolar macrophages (PAMs) was examined...
February 13, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29438849/association-between-histological-alterations-in-the-thymus-and-sudden-infant-death-syndrome
#5
Ivan Varga, Ildikó Bódi, Veronika Mešťanová, Martin Kováč, Martin Klein
INTRODUCTION: Sudden infant death syndrome (SIDS) involves the death of an infant during the first year of life and it is among the leading causes of infant mortality worldwide. One hypothesis regarding the pathogenesis of SIDS is that it results from a combination of three independent factors: endogenous vulnerability, a critical time window during postnatal development, and exogenous stressors. This hypothesis is known as the "triple-risk model". METHODS: In this study, we used an immunohistological approach to compare the cellular microenvironments of thymuses from 19 infants whose sudden death was classified as SIDS and a control group, which consisted of thymuses from age-matched children undergoing surgery for various congenital heart defects...
February 8, 2018: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/29435315/fluid-resuscitation-with-lactated-ringer-s-solution-vs-normal-saline-in-acute-pancreatitis-a-triple-blind-randomized-controlled-trial
#6
Enrique de-Madaria, Iván Herrera-Marante, Verónica González-Camacho, Laia Bonjoch, Noé Quesada-Vázquez, Isabel Almenta-Saavedra, Cayetano Miralles-Maciá, Nelly G Acevedo-Piedra, Manuela Roger-Ibáñez, Claudia Sánchez-Marin, Rosa Osuna-Ligero, Ángel Gracia, Pere Llorens, Pedro Zapater, Vikesh K Singh, Rocío Moreu-Martín, Daniel Closa
Background: Little is known regarding the optimal type of fluid resuscitation in acute pancreatitis (AP). Objective: The objective of this article was to compare the effect of lactated Ringer's solution (LR) vs normal saline (NS) in the inflammatory response in AP. Methods: We conducted a triple-blind, randomized, controlled trial. Patients ≥ 18 admitted with AP were eligible. Patients were randomized to receive LR or NS. Primary outcome variables were number of systemic inflammatory response syndrome (SIRS) criteria at 24 hours, 48 hours and 72 hours and blood C-reactive protein (CRP) levels at 48 hours and 72 hours...
February 2018: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29420734/convergent-pathways-of-the-hyperferritinemic-syndromes
#7
Grant S Schulert, Scott W Canna
Hyperferritinemia and pronounced hemophagocytosis help distinguish a subset of patients with a particularly inflammatory and deadly systemic inflammatory response syndrome. Two clinically similar disorders typify these hyperferritinemic syndromes: hemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS). HLH is canonically associated with a complete disturbance of perforin/granzyme-mediated cytotoxicity, whereas MAS occurs in the context of the related rheumatic diseases systemic juvenile idiopathic arthritis (SJIA) and adult-onset Still's disease (AOSD), with associated IL-1 family cytokine activation...
February 6, 2018: International Immunology
https://www.readbyqxmd.com/read/29415950/acute-exposure-to-crotonaldehyde-induces-dysfunction-of-immune-system-in-male-wistar-rats
#8
Limeng Wang, Zhihua Yang, Long Xu, Xiujie Pan, Xingyu Liu, Junwei Zhao, Xiang Li, Maoxiang Zhu, Jianping Xie
Crotonaldehyde is a ubiquitous air pollutant in the environment. It is reported to be harmful to the biosystems in vivo and in vitro. The exposure to crotonaldehyde irritates the mucous membranes and induces edema, hyperemia, cell necrosis, inflammation, and acute respiratory distress syndrome in the lungs. However, the effects of crotonaldehyde on the immune system have not been reported. In the present study, 6-8 weeks old male Wistar rats were exposed to crotonaldehyde by intratracheal instillation at doses of 4, 8, and 16 μL/kg body weight (b...
2018: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/29409136/novel-unc13d-intronic-variant-disrupting-a-nf%C3%AE%C2%BAb-enhancer-in-a-patient-with-recurrent-macrophage-activation-syndrome-and-systemic-juvenile-idiopathic-arthritis
#9
Grant S Schulert, Mingce Zhang, Ammar Husami, Ndate Fall, Hermine Brunner, Kejian Zhang, Randy Q Cron, Alexei A Grom
OBJECTIVE: Macrophage activation syndrome (MAS) is a life-threatening complication of systemic juvenile idiopathic arthritis (SJIA), and has pathologic similarity to hemophagocytic lymphohistiocytosis (HLH). Intronic variants in UNC13D are found in patients with familial HLH-3 (FHL3), but the role of non-coding variants in MAS is unknown. The objective of this study was to identify deep intronic UNC13D variants in patients with MAS. METHODS: A custom enrichment library was constructed to sequence approximately 1 MB flanking UNC13D in 24 patients with SJIA, recurrent MAS, and negative prior genetic (exon/coding) testing...
February 6, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29393440/serum-containing-gengnianchun-formula-suppresses-amyloid%C3%A2-%C3%AE-%C3%A2-induced-inflammatory-cytokines-in-bv%C3%A2-2-microglial-cells-by-inhibiting-the-nf%C3%A2-%C3%AE%C2%BAb-and-jnk-signaling-pathways
#10
Pin-Li Chen, Wen-Jun Wang, Yan-Qiu Rao, Jun Li, Ming-Jun Cheng
As the resident macrophages of the brain's innate immune system, microglial cells are key modulators in the neurodegenerative disease Alzheimer's disease (AD). In particular, the activation and accumulation of microglial cells around amyloid plaques is considered to result in chronic neuroinflammation. Although the pathologic mechanism remains to be fully elucidated, inflammation has been shown to be critical in the pathogenesis of AD. The Gengnianchun (GNC) formula has long been used to treat perimenopausal syndrome clinically, and is particularly effective in improving learning ability and memory...
January 31, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29386835/drug-reaction-with-eosinophilia-and-systemic-symptoms-associated-with-reactivation-of-epstein-barr-virus-and-or-cytomegalovirus-leading-to-hemophagocytic-syndrome-in-one-of-two-patients
#11
Jianhua Liang, Hui Qu, Xiaowen Wang, Aiping Wang, Lingling Liu, Ping Tu, Ruoyu Li, Mingyue Wang
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a hypersensitivity reaction characterized by maculopapular rash, exfoliative dermatitis, lymphadenopathy, fever, eosinophilia, and involvement of internal organs. Evidence for reactivation of herpes family viruses has been observed in some DRESS patients, and activated CD8+ T lymphocytes are largely directed against Epstein-Barr virus. Here, we report two cases complicated with this infection. Both patients received antibiotics and non-steroidal anti-inflammatory drugs...
February 2018: Annals of Dermatology
https://www.readbyqxmd.com/read/29386593/autoinflammatory-diseases-free-il-18-causes-macrophage-activation-syndrome
#12
Liesbet Lieben
No abstract text is available yet for this article.
February 1, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/29384877/acute-appendicitis-complicated-with-necrotizing-fasciitis-in-a-patient-with-adult-onset-still-s-disease-a-case-report
#13
Zheng-Hao Huang, Yu-Chen Chiu, Li-Lu Ho, Hsiu-Lung Fan, Chun-Chi Lu
RATIONALE: Adult-onset Still disease (AOSD) is a rare systemic inflammatory disease of unknown etiology characterized by evanescent salmon-pink rash, spiking fever, arthralgia/ arthritis, and lymphadenopathy. AOSD sometimes was fatal when it is complicated by macrophage activation syndrome (MAS) or hemophagocytic lymphohistiocytosis (HLH). Nonetheless, the literature provides no recommendations for treatment of AOSD patients with severe sepsis. PATIENT CONCERNS: A previously healthy 65-year-old man with history of AOSD was referred to our hospital for persistent right lower quadrant abdominal pain for 2 days...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29379544/the-influence-of-various-therapeutic-regimens-on-early-clinical-and-laboratory-response-and-outcome-of-children-with-secondary-hemophagocytic-lymphohistiocytosis
#14
Piotr Buda, Piotr Gietka, Janusz B Książyk, Maciej Machaczka
Introduction: Secondary hemophagocytic lymphohistiocytosis (sHLH) is a life-threatening syndrome of severe hyperinflammation which is often triggered by infection or autoimmune disease (macrophage activation syndrome - MAS). The aim of our study was to assess the frequency of sHLH/MAS in children treated in our institution and to compare the effectiveness of various therapeutic interventions. Material and methods: Between 2005 and 2013, 24 children (age: 1-17 years) were consecutively treated for sHLH/MAS...
January 2018: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29378952/olt1177-a-%C3%AE-sulfonyl-nitrile-compound-safe-in-humans-inhibits-the-nlrp3-inflammasome-and-reverses-the-metabolic-cost-of-inflammation
#15
Carlo Marchetti, Benjamin Swartzwelter, Fabia Gamboni, Charles P Neff, Katrin Richter, Tania Azam, Sonia Carta, Isak Tengesdal, Travis Nemkov, Angelo D'Alessandro, Curtis Henry, Gerald S Jones, Scott A Goodrich, Joseph P St Laurent, Terry M Jones, Curtis L Scribner, Robert B Barrow, Roy D Altman, Damaris B Skouras, Marco Gattorno, Veronika Grau, Sabina Janciauskiene, Anna Rubartelli, Leo A B Joosten, Charles A Dinarello
Activation of the NLRP3 inflammasome induces maturation of IL-1β and IL-18, both validated targets for treating acute and chronic inflammatory diseases. Here, we demonstrate that OLT1177, an orally active β-sulfonyl nitrile molecule, inhibits activation of the NLRP3 inflammasome. In vitro, nanomolar concentrations of OLT1177 reduced IL-1β and IL-18 release following canonical and noncanonical NLRP3 inflammasome activation. The molecule showed no effect on the NLRC4 and AIM2 inflammasomes, suggesting specificity for NLRP3...
January 29, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29372302/pathogenic-role-of-inflammatory-response-during-shiga-toxin-associated-hemolytic-uremic-syndrome-hus
#16
Ramon Alfonso Exeni, Romina Jimena Fernandez-Brando, Adriana Patricia Santiago, Gabriela Alejandra Fiorentino, Andrea Mariana Exeni, Maria Victoria Ramos, Marina Sandra Palermo
Hemolytic uremic syndrome (HUS) is defined as a triad of noninmune microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury. The most frequent presentation is secondary to Shiga toxin (Stx)-producing Escherichia coli (STEC) infections, which is termed postdiarrheal, epidemiologic or Stx-HUS, considering that Stx is the necessary etiological factor. After ingestion, STEC colonize the intestine and produce Stx, which translocates across the intestinal epithelium. Once Stx enters the bloodstream, it interacts with renal endothelial and epithelial cells, and leukocytes...
January 25, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29371779/hyperferritinemia-in-hemophagocytic-lymphohistiocytosis-a-single-institution-experience-in-pediatric-patients
#17
Surupa Basu, Biplab Maji, Santanu Barman, Apurba Ghosh
Hemophagocytic lymphohistiocytosis (HLH) is an inflammatory condition that may run a rapid fatal course and calls for prompt diagnosis. Early intervention with steroids and other immunosuppressive drugs can contain the disease process and favours positive outcome. Ferritin ≥500 ng/ml is a HLH diagnostic criterion. We evaluated the diagnostic potential of admission ferritin, in children with HLH. Pediatric patients of a referral teaching hospital from Feb 2010-Oct 2013 having been investigated for ferritin on admission were included...
January 2018: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/29370863/application-of-the-international-league-against-rheumatism-classification-criteria-for-systemic-juvenile-idiopathic-arthritis-as-a-prognostic-factor-in-patients-with-adults-onset-still-s-disease
#18
Ji Won Yang, Eunyoung Lee, Ji-Yeon Seo, Ju-Yang Jung, Chang-Hee Suh, Hyoun-Ah Kim
BACKGROUND: Adult-onset Still's disease (AOSD) is an adult form of systemic juvenile idiopathic arthritis (JIA) that differs from the latter in its classification. This study evaluated the concordance between the International League Against Rheumatism (ILAR) criteria for systemic JIA and the Yamaguchi criteria and then compared their possible prognostic value in patients with AOSD. METHODS: In a retrospective review of 169 adults with suspected AOSD, patients were classified according to the Yamaguchi or ILAR criteria...
January 25, 2018: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/29366678/galectin-3-enhances-avian-h5n1-influenza-a-virus-induced-pulmonary-inflammation-by-promoting-nlrp3-inflammasome-activation
#19
Yu-Jung Chen, Sheng-Fan Wang, I-Chun Weng, Ming-Hsiang Hong, Tzu-Han Lo, Jia-Tsrong Jan, Li-Chung Hsu, Huan-Yuan Chen, Fu-Tong Liu
Highly pathogenic avian influenza A H5N1 virus causes pneumonia and acute respiratory distress syndrome in humans. Virus-induced excessive inflammatory response contributes to severe disease and high mortality rates. Galectin-3, a β-galactoside-binding protein widely distributed in immune and epithelial cells, regulates various immune functions and modulates microbial infections. Here we describe galectin-3 up-regulation in mouse lung tissue following challenges with the H5N1 influenza virus. We investigated the effects of endogenous galectin-3 on H5N1 infection and found that survival of galectin-3 knockout (Gal-3KO) mice was comparable to wild-type (WT) mice following infections...
January 20, 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/29362018/role-of-microbiota-derived-lipopolysaccharide-in-adipose-tissue-inflammation-adipocyte-size-and-pyroptosis-during-obesity
#20
Lars-Georg Hersoug, Peter Møller, Steffen Loft
It has been established that ingestion of a high-fat diet increases the blood levels of lipopolysaccharides (LPS) from Gram-negative bacteria in the gut. Obesity is characterised by low-grade systemic and adipose tissue inflammation. This is suggested to be implicated in the metabolic syndrome and obesity. In the present review, we hypothesise that LPS directly and indirectly participates in the inflammatory reaction in adipose tissue during obesity. The experimental evidence shows that LPS is involved in the transition of macrophages from the M2 to the M1 phenotype...
January 24, 2018: Nutrition Research Reviews
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