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https://www.readbyqxmd.com/read/28926772/ultrasound-assisted-interaction-between-chlorin-e6-and-human-serum-albumin-ph-dependence-singlet-oxygen-production-and-formulation-effect
#1
Mihaela N Mocanu, Fei Yan
The interaction between chlorin e6 (Ce6) and human serum albumin (HSA) in the presence and absence of ultrasound have been investigated by ultraviolet-visible absorption spectroscopy and fluorescence spectroscopy. Ce6 is found to bind strongly to HSA at or near physiological pH conditions, but the strength of the binding is significantly weakened at lower pHs. The intrinsic fluorescence of HSA is incrementally quenched with increasing concentration of Ce6, and the quenching is enhanced after exposure to high-frequency ultrasound...
September 13, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28926506/family-perspectives-on-visiting-the-pediatric-emergency-department-for-migraine-a-qualitative-study
#2
Serena Laura Orr, Liam OʼSullivan, Roger Zemek, Natalie M Ward, Hugh J McMillan
OBJECTIVE: The aim of this study was to explore the perspectives of families regarding their expectations and experience of visiting the emergency department (ED) for migraine. METHODS: This was a qualitative study involving the families of 25 patients aged 10 to 18 years receiving ED care for acute migraine. Following their visit, independent semistructured telephone interviews were conducted with both the patient and parent or guardian. Questions were designed to explore factors pertaining to the family's perspective regarding their visit to the ED and expectations for the ED visit...
September 18, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28926488/potential-acceptability-of-a-pediatric-ventilator-management-computer-protocol
#3
Katherine A Sward, Christopher J L Newth, Robinder G Khemani, Kent Page, Kathleen L Meert, Joseph A Carcillo, Thomas P Shanley, Frank W Moler, Murray M Pollack, Heidi J Dalton, David L Wessel, John T Berger, Robert A Berg, Rick E Harrison, Allan Doctor, J Michael Dean, Richard Holobkov, Tammara L Jenkins, Carol E Nicholson
OBJECTIVES: To examine issues regarding the granularity (size/scale) and potential acceptability of recommendations in a ventilator management protocol for children with pediatric acute respiratory distress syndrome. DESIGN: Survey/questionnaire. SETTING: The eight PICUs in the Collaborative Pediatric Critical Care Research Network. PARTICIPANTS: One hundred twenty-two physicians (attendings and fellows). INTERVENTIONS: None...
September 16, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28926474/parasympathetic-activation-enhanced-by-slow-respiration-modulates-early-auditory-sensory-gating
#4
Atsushi Aoyama, Yu Shimura, Takao Ohmuta, Yohei Nomoto, Masashi Kawasumi
Sensory gating is a preattentional mechanism to filter irrelevant information from the environment. It is typically reflected as a suppression of the event-related P50 component for successive sounds in the auditory modality. Although stress-induced sympathetic activation has been reported to disrupt P50 suppression, little is known about the modulatory effect of parasympathetic activation on early auditory sensory gating. We determined the parasympathetic effect on the magnetic P50 (P50m) suppression by controlling the respiratory rhythm and recording data simultaneously with magnetoencephalography and electrocardiography, using three successive click sounds as stimulus and ten normal individuals as study participants...
September 18, 2017: Neuroreport
https://www.readbyqxmd.com/read/28926262/effect-of-the-incorporation-of-nano-sized-titanium-dioxide-on-the-interfacial-properties-of-dppc-langmuir-monolayers
#5
Eduardo Guzmán, Eva Santini, Michele Ferrari, Libero Liggieri, Francesca Ravera
The effect of the incorporation of hydrophilic titanium dioxide (TiO2) nanoparticles on the interfacial properties of Langmuir monolayers of 1,2-Dipalmitoyl-sn-glycerol-3-phosphocholine (DPPC) has been evaluated combining interfacial thermodynamic studies, dilatational rheology and Brewster Angle Microscopy (BAM). The results show that the TiO2 nanoparticles are able to penetrate into DPPC layers, modifying the organization of the molecules and, consequently, the phase behaviour and viscoelastic properties of the systems...
September 19, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28926134/early-genetic-aberrations-in-patients-with-sporadic-colorectal-cancer
#6
Brooke R Druliner, Xiaoyang Ruan, Hugues Sicotte, Daniel O'Brien, Hongfang Liu, Jean-Pierre A Kocher, Lisa Boardman
Chromosome instability (CIN) is widely observed in both sporadic and hereditary colorectal cancer (CRC). Defects in APC and WNT signaling are primarily associated with CIN in hereditary CRC, but the genetic causes for CIN in sporadic CRC remain elusive. Using high-density SNP array and exome data from The Cancer Genome Atlas, we characterized loss of heterozygosity (LOH) and copy number variation (CNV) in the peripheral blood, normal colon and corresponding tumor tissue in 15 CRC patients with proficient mismatch repair (MMR) and 24 CRC patients with deficient MMR...
September 19, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28925893/big-data-analyses-for-continuous-evaluation-of-pharmacotherapy-a-proof-of-principle-with-doxapram-in-preterm-infants
#7
Robert Flint, Willem van Weteringen, Swantje Völler, Jarinda A Poppe, Birgit Cp Koch, Ronald de Groot, Dick Tibboel, Catherijne Aj Knibbe, Irwin Km Reiss, Sinno Hp Simons
BACKGROUND: Drug effect evaluation is often based on subjective interpretation of a selection of patient data. Continuous analyses of high frequency patient monitor data are a valuable source to measure drug effects. However, these have not yet been fully explored in clinical care. We aim to evaluate the usefulness and applicability of high frequency physiological data for analyses of pharmacotherapy. METHODS: As a proof of principle, the effects of doxapram, a respiratory stimulant, on the oxygenation in preterm infants were studied...
September 18, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28925523/bdnf-haplo-insufficiency-impairs-high-frequency-cortical-oscillations-in-mice
#8
Nigel C Jones, Matthew Hudson, Joshua Foreman, Gil Rind, Rachel Hill, Elizabeth E Manning, Maarten van den Buuse
Schizophrenia is a complex psychiatric disorder with a heterogeneous aetiology involving genetic and environmental factors. Deficiencies in both brain-derived neurotrophic factor (BDNF) and NMDA receptor function have been implicated in the disorder, and may play causal and synergistic roles. Perturbations in the regulation of electrophysiological signals, including high-frequency (gamma: 30-80 Hz and beta: 20-30 Hz) neuronal oscillations, are also associated with the disorder. This study investigated the influence of BDNF deficiency and NMDA receptor hypofunction on electrophysiological responses to brief acoustic stimuli...
September 19, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28924578/effects-of-subthalamic-nucleus-deep-brain-stimulation-on-objective-sleep-outcomes-in-parkinson-s-disease
#9
Amy W Amara, Harrison C Walker, Allen Joop, Gary Cutter, Jennifer L DeWolfe, Susan M Harding, David G Standaert
BACKGROUND: Sleep dysfunction is a common and disabling non-motor symptom in Parkinson's disease. Deep brain stimulation (DBS) of the subthalamic nucleus (STN) improves motor symptoms and subjective sleep in PD, but alternative stimulation parameters to optimize sleep have not been explored. We hypothesized that low frequency STN DBS would improve objective sleep more than conventional settings. METHODS: Twenty PD subjects with STN DBS (18 unilateral, 2 bilateral) underwent 3 non-consecutive nights of polysomnography: DBS off; DBS high frequency (≥130 Hz); and DBS low frequency (60 Hz)...
March 2017: Movement Disorders Clinical Practice
https://www.readbyqxmd.com/read/28924535/benign-pathogenic-and-copy-number-variations-of-unknown-clinical-significance-in-patients-with-congenital-malformations-and-developmental-delay
#10
M Mihaylova, R Staneva, D Toncheva, M Pancheva, S Hadjidekova
The high frequency (3.0-5.0%) of congenital anomalies (CA) and intellectual disabilities (IDs), make them a serious problem, responsible for a high percentage (33.0%) of neonatal mortality. The genetic cause remains unclear in 40.0% of cases. Recently, molecular karyotyping has become the most powerful method for detection of pathogenic imbalances in patients with multiple CAs and IDs. This method is with high resolution and gives us the opportunity to investigate and identify candidate genes that could explain the genotype-phenotype correlations...
June 30, 2017: Balkan Journal of Medical Genetics: BJMG
https://www.readbyqxmd.com/read/28924507/awareness-about-antibiotic-resistance-in-a-self-medication-user-group-from-eastern-romania-a-pilot-study
#11
Gabi Topor, Ionela-Alina Grosu, Cristina Mihaela Ghiciuc, Aurel Lulu Strat, Cătălina Elena Lupuşoru
BACKGROUND: Awareness about antibiotic resistance depends on the attitudes and information about antibiotic resistance of both patients and physicians. Persons who practice self-medication are at high risk of also self-medicating with antibiotics. The purpose of the present study was to evaluate the awareness about antibiotic resistance by investigating the practice in a group of self-medication users in a sample of adults in Romania and the variables associated with such practice. MATERIAL AND METHODS: A cross-sectional self-filled questionnaire based study was conducted from December 2016 through January 2017 amongst 218 self-medication users (SMUG)...
2017: PeerJ
https://www.readbyqxmd.com/read/28924195/patterns-of-change-in-high-frequency-precipitation-variability-over-north-america
#12
Susana Roque-Malo, Praveen Kumar
Precipitation variability encompasses attributes associated with the sequencing and duration of events of the full range of magnitudes. However, climate change studies have largely focused on extreme events. Using analyses of long-term weather station data, we show that high frequency events, such as fraction of wet days in a year and average duration of wet and dry periods, are undergoing significant changes across North America. Further, these changes are more prevalent and larger than those associated with extremes...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28923406/negative-environmental-impacts-of-antibiotic-contaminated-effluents-from-pharmaceutical-industries
#13
Ana Bielen, Ana Šimatović, Josipa Kosić-Vukšić, Ivan Senta, Marijan Ahel, Sanja Babić, Tamara Jurina, Juan José González Plaza, Milena Milaković, Nikolina Udiković-Kolić
Effluents from pharmaceutical industries are recognized as significant contributors to aquatic pollution with antibiotics. Although such pollution has been mostly reported in Asia, knowledge on industrial discharges in other regions of the world, including Europe, and on the effects associated with such exposures is still limited. Thus, we performed chemical, microbiological and ecotoxicological analyses of effluents from two Croatian pharmaceutical industries during four seasons. In treated effluents of the company synthesizing macrolide antibiotic azithromycin (AZI), the total concentration of AZI and two macrolide by-products from its synthesis was 1-3 orders of magnitude higher in winter and springtime (up to 10...
September 9, 2017: Water Research
https://www.readbyqxmd.com/read/28923309/altered-penile-caveolin-expression-in-diabetes-potential-role-in-erectile-dysfunction
#14
Jay Parikh, Alice Zemljic-Harpf, Johnny Fu, Dimosthenis Giamouridis, Tung-Chin Hsieh, Adam Kassan, Karnam S Murthy, Valmik Bhargava, Hemal H Patel, M Raj Rajasekaran
BACKGROUND: The pathophysiology of increased severity of erectile dysfunction in men with diabetes and their poor response to oral pharmacotherapy are unclear. Defective vascular endothelium and consequent impairment in the formation and action of nitric oxide (NO) are implicated as potential mechanisms. Endothelial NO synthase, critical for NO generation, is localized to caveolae, plasma membrane lipid rafts enriched in structural proteins, and caveolins. Type 2 diabetes mellitus (T2DM)-induced changes in caveolin expression are recognized to play a role in cardiovascular dysfunction...
September 8, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28922628/high-frequency-electroporation-efficiency-is-under-control-of-membrane-capacitive-charging-and-voltage-potential-relaxation
#15
Vitalij Novickij, Paulius Ruzgys, Audrius Grainys, Saulius Šatkauskas
The study presents the proof of concept for a possibility to achieve a better electroporation in the MHz pulse repetition frequency (PRF) region compared to the conventional low frequency protocols. The 200ns×10 pulses bursts of 10-14kV/cm have been used to permeabilize Chinese hamster ovary (CHO) cells in a wide range (1Hz-1MHz) of PRF. The permeabilization efficiency was evaluated using fluorescent dye assay (propidium iodide) and flow cytometry. It was determined that a threshold PRF exists when the relaxation of the cell transmembrane potential is longer than the delay between the consequent pulses, which results in accumulation of the charge on the membrane...
September 14, 2017: Bioelectrochemistry
https://www.readbyqxmd.com/read/28922575/the-hospital-anxiety-and-depression-scale-factor-structure-and-psychometric-properties-in-older-adolescents-and-young-adults-with-autism-spectrum-disorder
#16
Mirko Uljarević, Amanda L Richdale, Helen McConachie, Darren Hedley, Ru Ying Cai, Hannah Merrick, Jeremy R Parr, Ann Le Couteur
Despite the high frequency of anxiety and depression symptoms in individuals with Autism Spectrum Disorder (ASD) and a significant impact of these comorbidities on both individuals with ASD and their families, research on the validity of anxiety and depression measures in the ASD population is currently lacking. The aim of this study was to explore the psychometric properties of the Hospital Anxiety and Depression Scale [HADS; Zigmond & Snaith, ] in a sample of older adolescents and young adults with ASD. One hundred and fifty one participants (UK Transition longitudinal study: N = 106; 75 males, Mage  = 16...
September 18, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28922535/power-and-coherence-of-cortical-high-frequency-oscillations-during-wakefulness-and-sleep
#17
Matías Cavelli, Daniel Rojas-Líbano, Natalia Schwarzkopf, Santiago Castro-Zaballa, Joaquín Gonzalez, Alejandra Mondino, Noelia Santana, Luciana Benedetto, Atilio Falconi, Pablo Torterolo
Recently, a novel type of fast cortical oscillatory activity that occurs between 110 and 160 Hz (high-frequency oscillations (HFO)) was described. HFO are modulated by the theta rhythm in hippocampus and neocortex during active wakefulness and REM sleep. Since theta-HFO coupling increases during REM, a role for HFO in memory consolidation has been proposed. However, global properties like the cortex-wide topographic distribution, and the cortico-cortical coherence remain unknown. In the present study, we recorded the electroencephalogram during sleep and wakefulness in the rat, and analyzed the spatial extent of the HFO band power and coherence...
September 18, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28922491/temporal-and-remote-tuning-of-piezophotonic-effect-induced-luminescence-and-color-gamut-via-modulating-magnetic-field
#18
Man-Chung Wong, Li Chen, Gongxun Bai, Long-Biao Huang, Jianhua Hao
Light-emitting materials have been extensively investigated because of their widespread applications in solid-state lighting, displays, sensors, and bioimaging. In these applications, it is highly desirable to achieve tunable luminescence in terms of luminescent intensity and wavelength. Here, a convenient physical approach of temporal and remote tuning of light-emitting wavelength and color is demonstrated, which is greatly different from conventional methods. It is shown that by modulating the frequency of magnetic-field excitation at room temperature, luminescence from the flexible composites of ZnS:Al, Cu phosphors induced by the piezophotonic effect can be tuned in real time and in situ...
September 18, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28922354/reconstructing-promoter-activity-from-lux-bioluminescent-reporters
#19
Mudassar Iqbal, Neil Doherty, Anna M L Page, Saara N A Qazi, Ishan Ajmera, Peter A Lund, Theodore Kypraios, David J Scott, Philip J Hill, Dov J Stekel
The bacterial Lux system is used as a gene expression reporter. It is fast, sensitive and non-destructive, enabling high frequency measurements. Originally developed for bacterial cells, it has also been adapted for eukaryotic cells, and can be used for whole cell biosensors, or in real time with live animals without the need for euthanasia. However, correct interpretation of bioluminescent data is limited: the bioluminescence is different from gene expression because of nonlinear molecular and enzyme dynamics of the Lux system...
September 18, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28922351/estimation-of-the-mechanical-properties-of-the-eye-through-the-study-of-its-vibrational-modes
#20
M Á Aloy, J E Adsuara, P Cerdá-Durán, M Obergaulinger, J J Esteve-Taboada, T Ferrer-Blasco, R Montés-Micó
Measuring the eye's mechanical properties in vivo and with minimally invasive techniques can be the key for individualized solutions to a number of eye pathologies. The development of such techniques largely relies on a computational modelling of the eyeball and, it optimally requires the synergic interplay between experimentation and numerical simulation. In Astrophysics and Geophysics the remote measurement of structural properties of the systems of their realm is performed on the basis of (helio-)seismic techniques...
2017: PloS One
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