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https://www.readbyqxmd.com/read/28549276/different-seizure-onset-patterns-in-mesiotemporal-lobe-epilepsy-have-a-distinct-interictal-signature
#1
Birgit Frauscher, Nicolás von Ellenrieder, François Dubeau, Jean Gotman
OBJECTIVE: Experimental research demonstrated that distinct underlying mechanisms go along with different seizure-onset patterns on EEG. These different mechanisms may reflect different tissue abnormalities which, we hypothesize, could also be reflected in morphological differences in the interictal epileptic and background EEG activity. METHODS: We searched our database of intracranial EEG recordings for mesiotemporal lobe epilepsy patients with either predominant low-voltage fast activity (LVF) or periodic spiking (PS)...
May 9, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28548509/ultrafast-reversal-of-the-ferroelectric-polarization
#2
R Mankowsky, A von Hoegen, M Först, A Cavalleri
We report on the demonstration of ultrafast optical reversal of the ferroelectric polarization in LiNbO_{3}. Rather than driving the ferroelectric mode directly, we couple to it indirectly by resonant excitation of an auxiliary high-frequency phonon mode with femtosecond midinfrared pulses. Because of strong anharmonic coupling between these modes, the atoms are directionally displaced along the ferroelectric mode and the polarization is transiently reversed, as revealed by time-resolved, phase-sensitive, second-harmonic generation...
May 12, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28546681/heart-rate-variability-changes-during-and-after-the-practice-of-bhramari-pranayama
#3
L Nivethitha, N K Manjunath, A Mooventhan
BACKGROUND: Yoga is an ancient Indian science as well as the way of life. Pranayama is one of the most important yogic practices. Bhramari pranayama was shown to produce a reduction in blood pressure after the practice and thus reported to produce parasympathetic activity. However, there are no known studies reported the heart rate variability (HRV) changes either during or after the practice of Bhramari. Hence, this study aims at evaluating the HRV changes during and after the practice...
May 2017: International Journal of Yoga
https://www.readbyqxmd.com/read/28546634/high-gain-graphene-transistors-with-a-thin-alox-top-gate-oxide
#4
Erica Guerriero, Paolo Pedrinazzi, Aida Mansouri, Omid Habibpour, Michael Winters, Niklas Rorsman, Ashkan Behnam, Enrique A Carrion, Amaia Pesquera, Alba Centeno, Amaia Zurutuza, Eric Pop, Herbert Zirath, Roman Sordan
The high-frequency performance of transistors is usually assessed by speed and gain figures of merit, such as the maximum oscillation frequency f max, cutoff frequency f T, ratio f max/f T, forward transmission coefficient S 21, and open-circuit voltage gain A v. All these figures of merit must be as large as possible for transistors to be useful in practical electronics applications. Here we demonstrate high-performance graphene field-effect transistors (GFETs) with a thin AlOx gate dielectric which outperform previous state-of-the-art GFETs: we obtained f max/f T > 3, A v > 30 dB, and S 21 = 12...
May 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28546586/two-dimensional-penta-bp5-sheets-high-stability-strain-tunable-electronic-structure-and-excellent-mechanical-properties
#5
Shijie Liu, Bo Liu, Xuhan Shi, Jiayin Lv, Shifeng Niu, Mingguang Yao, Quanjun Li, Ran Liu, Tian Cui, Bingbing Liu
Two-dimensional (2D) crystals exhibit unique and exceptional properties and show promise for various applications. In this work, we systematically studied the structures of a 2D boronphosphide (BP) monolayer with different stoichiometric ratios (BPx, x = 1, 2, 3, 4, 5, 6 and 7) and observed that each compound had a stable 2D structure with metallic or semiconducting electronic properties. Surprisingly, for the BP5 compounds, we discovered a rare penta-graphene-like 2D structure with a tetragonal lattice...
May 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28546374/pediatric-ards
#6
Ira M Cheifetz
The Pediatric Acute Lung Injury Consensus Conference (PALICC) has provided the critical care community with the first pediatric-focused definition for ARDS. The PALICC recommendations provide guidance on conventional ventilator management, gas exchange goals, use of high-frequency ventilation, adjunct management approaches, and the application of extracorporeal membrane oxygenation for pediatric ARDS (PARDS). Although outcomes for PARDS have improved over the past decade, mortality and morbidity remain significant...
June 2017: Respiratory Care
https://www.readbyqxmd.com/read/28545452/a-simple-fast-and-inexpensive-method-for-mutation-scanning-of-cftr-gene
#7
Juan Emilio Figueredo Lago, Anny Armas Cayarga, Yaimé Josefina González González, Teresa Collazo Mesa
BACKGROUND: Mutation scanning methods in Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene may not distinguish between a Cystic Fibrosis (CF) causing mutation and a benign variant. We have developed a simple and fast method for scanning 14 selected CF-causing mutations which have high frequency in Latin America. METHODS: In a group of 35 samples coming from CF patients previously characterized and using two allele-specific real-time multiplex PCRs targeting wild-type and mutant alleles respectively, we detect the presence of mutations by analyzing the Ct variation...
May 25, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/28545070/pou4f3-mutation-screening-in-japanese-hearing-loss-patients-massively-parallel-dna-sequencing-based-analysis-identified-novel-variants-associated-with-autosomal-dominant-hearing-loss
#8
Tomohiro Kitano, Maiko Miyagawa, Shin-Ya Nishio, Hideaki Moteki, Kiyoshi Oda, Kenji Ohyama, Hiromitsu Miyazaki, Hiroshi Hidaka, Ken-Ichi Nakamura, Takaaki Murata, Rina Matsuoka, Yoko Ohta, Nobuhiro Nishiyama, Kozo Kumakawa, Sakiko Furutate, Satoshi Iwasaki, Takechiyo Yamada, Yumi Ohta, Natsumi Uehara, Yoshihiro Noguchi, Shin-Ichi Usami
A variant in a transcription factor gene, POU4F3, is responsible for autosomal dominant nonsyndromic hereditary hearing loss, DFNA15. To date, 14 variants, including a whole deletion of POU4F3, have been reported to cause HL in various ethnic groups. In the present study, genetic screening for POU4F3 variants was carried out for a large series of Japanese hearing loss (HL) patients to clarify the prevalence and clinical characteristics of DFNA15 in the Japanese population. Massively parallel DNA sequencing of 68 target candidate genes was utilized in 2,549 unrelated Japanese HL patients (probands) to identify genomic variations responsible for HL...
2017: PloS One
https://www.readbyqxmd.com/read/28544821/predictive-model-for-high-frequency-microsatellite-instability-in-colorectal-cancer-patients-over-50%C3%A2-years-of-age
#9
Kenji Fujiyoshi, Tatsuro Yamaguchi, Miho Kakuta, Akemi Takahashi, Yoshiko Arai, Mina Yamada, Gou Yamamoto, Sachiko Ohde, Misato Takao, Shin-Ichiro Horiguchi, Soichiro Natsume, Shinsuke Kazama, Yusuke Nishizawa, Yoji Nishimura, Yoshito Akagi, Hirohiko Sakamoto, Kiwamu Akagi
Microsatellite instability (MSI) is an important biomarker for screening for Lynch syndrome, and also of response to immune checkpoint inhibitors. The aim of this study is to create a predictive model to determine which elderly patients with colorectal cancer (CRC) should undergo MSI and/or immunohistochemistry testing on the basis of clinicopathological data. We analyzed a test cohort of CRC patients aged ≥50 years (n = 2219) by multivariate logistic regression analyses to identify predictors of high-frequency MSI (MSI-H)...
May 23, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28544507/the-effect-of-binaural-beat-technology-on-the-cardiovascular-stress-response-in-military-service-members-with-postdeployment-stress
#10
MeLisa A Gantt, Stephanie Dadds, Debra S Burns, Dale Glaser, Angelo D Moore
PURPOSE: To assess the efficacy of embedded theta brainwave frequency in music using binaural beat technology (BBT) compared to music alone on the cardiovascular stress response in military service members with postdeployment stress. DESIGN: A double-blinded, randomized, pre- and postintervention trial. METHODS: Seventy-four military services members with complaint of postdeployment stress were randomized to either music with BBT or music alone...
May 23, 2017: Journal of Nursing Scholarship
https://www.readbyqxmd.com/read/28544182/burst-or-high-frequency-10-khz-spinal-cord-stimulation-in-failed-back-surgery-syndrome-patients-with-predominant-back-pain-one-year-comparative-data
#11
Sajjad Muhammad, Sandra Roeske, Shafqat Rasul Chaudhry, Thomas Mehari Kinfe
OBJECTIVES: Burst and 10 kHz spinal cord stimulation (SCS) demonstrated improvement for failed back surgery syndrome (FBSS) with predominant, refractory back pain. Here, we report the long-term follow-up of a previously published study comparing the safety and efficacy of burst vs. 10 kHz SCS for predominant back pain (70% of global pain) of FBSS patients. METHODS: This comparative, observational study extended the follow-up period up to 20 months evaluating both SCS modalities...
May 24, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28543684/multiparity-modifies-contractile-properties-of-pelvic-muscles-affecting-the-genesis-of-vaginal-pressure-in-rabbits
#12
Rhode López-Juárez, René Zempoalteca, Dora Luz Corona-Quintanilla, Ismael Jiménez-Estrada, Francisco Castelán, Margarita Martínez-Gómez
AIMS: To characterize the contractile properties of the bulbospongiosus (Bsm), isquiocavernosus (Ism), and pubococcygeus muscles (Pcm), and their involvement in the genesis of vaginal pressure in nulliparous and multiparous rabbits. METHODS: Age-matched nulliparous and multiparous rabbits were used to record the isometric contractile responses of each muscle as well as the intravaginal pressure evoked by single square electrical pulses and stimulation trains of ascending frequency...
May 24, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28543299/low-occurrence-of-hbsag-but-high-frequency-of-transient-occult-hbv-infection-in-vaccinated-and-hbig-administered-infants-born-to-hbsag-positive-mothers
#13
Shan Zhou, Tingting Li, Jean-Pierre Allain, Bin Zhou, Yuming Zhang, Mei Zhong, Yongshui Fu, Chengyao Li
The status of chronic and occult HBV infection (OBI) in neonatal hepatitis B vaccine and immunoglobulin (HBIG) vaccinated infants born to HBsAg+ mothers was investigated at a major hospital in China. Seventy-seven and 15 blood samples were collected in first or second follow-up detection from the vaccinated babies aged 3 to 36 months born to 43 HBsAg+ or plus 25 HBeAg+ mothers. HBV infection was analyzed between the paired baby and mother by serology and DNA analysis. Among 77 children born to 68 HBsAg+ mothers, 3...
May 23, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28543030/defining-epileptogenic-networks-contribution-of-seeg-and-signal-analysis
#14
REVIEW
Fabrice Bartolomei, Stanislas Lagarde, Fabrice Wendling, Aileen McGonigal, Viktor Jirsa, Maxime Guye, Christian Bénar
Epileptogenic networks are defined by the brain regions involved in the production and propagation of epileptic activities. In this review we describe the historical, methodologic, and conceptual bases of this model in the analysis of electrophysiologic intracerebral recordings. In the context of epilepsy surgery, the determination of cerebral regions producing seizures (i.e., the "epileptogenic zone") is a crucial objective. In contrast with a traditional focal vision of focal drug-resistant epilepsies, the concept of epileptogenic networks has been progressively introduced as a model better able to describe the complexity of seizure dynamics and realistically describe the distribution of epileptogenic anomalies in the brain...
May 20, 2017: Epilepsia
https://www.readbyqxmd.com/read/28542715/hyperleucocytosis-in-paediatric-acute-myeloid-leukaemia-the-challenge-of-white-blood-cell-counts-above-200%C3%A2-%C3%A3-%C3%A2-10-9-l-the-nopho-experience-1984-2014
#15
Bernward Zeller, Heidi Glosli, Erik Forestier, Shau-Yin Ha, Kirsi Jahnukainen, Ólafur G Jónsson, Birgitte Lausen, Josefine Palle, Henrik Hasle, Jonas Abrahamsson
Hyperleucocytosis in paediatric acute myeloid leukaemia (AML) is associated with increased morbidity and mortality. We studied hyperleucocytosis in 890 patients with AML aged 0-18 years registered in the Nordic Society of Paediatric Haematology and Oncology (NOPHO) registry, with special focus on very high white blood cell counts (WBC >200 × 10/l). Eighty-six patients (10%) had WBC 100-199 × 10(9) /l and 57 (6%) had WBC ≥200 × 10(9) /l. Patients with WBC ≥200 × 10(9) /l had a high frequency of t(9;11) and a paucity of trisomy 8...
May 25, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28542264/child-mortality-hypothalamic-pituitary-adrenal-axis-activity-and-cellular-aging-in-mothers
#16
Cindy K Barha, Katrina G Salvante, Courtney W Hanna, Samantha L Wilson, Wendy P Robinson, Rachel M Altman, Pablo A Nepomnaschy
Psychological challenges, including traumatic events, have been hypothesized to increase the age-related pace of biological aging. Here we test the hypothesis that psychological challenges can affect the pace of telomere attrition, a marker of cellular aging, using data from an ongoing longitudinal-cohort study of Kaqchikel Mayan women living in a population with a high frequency of child mortality, a traumatic life event. Specifically, we evaluate the associations between child mortality, maternal telomere length and the mothers' hypothalamic-pituitary-adrenal axis (HPAA), or stress axis, activity...
2017: PloS One
https://www.readbyqxmd.com/read/28541383/the-technology-crisis-in-neuropsychology
#17
Justin B Miller, William B Barr
Neuropsychology has fallen reliant on outdated and labor intensive methods of data collection that are slow, highly inefficient, and expensive, and provide relatively data-poor estimates of human behavior despite rapid technological advance in most other fields of medicine. Here we present a brief historical overview of current testing practices in an effort to frame the current crisis, followed by an overview of different settings in which technology can and should be integrated. Potential benefits of laboratory based assessments, remote assessments, as well as passive and high-frequency data collection tools rooted in technology are discussed, along with several relevant examples and how these technologies might be deployed...
May 24, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28540941/chiral-differentiation-of-d-and-l-alanine-by-permethylated-%C3%AE-cyclodextrin-irmpd-spectroscopy-and-dft-methods
#18
Sung-Sik Lee, Soojin Park, Yin Hong, Jae-Ung Lee, Jun-Hyeok Kim, Dongkyung Yoon, Xianglei Kong, Sungyul Lee, Han Bin Oh
The gaseous chiral differentiation of alanine by permethylated β-cyclodextrin was studied using IRMPD spectroscopy and density functional theory calculations. The protonated non-covalent complexes of permethylated β-cyclodextrin and d- or l-alanine were mass-selected and investigated by IR laser pulses in the wavelength region of 2650-3800 cm(-1). The remarkably different features of the IRMPD spectra for d- and l-alanine are described, and their origin is elucidated by quantum chemical calculations. We show that the differentiation of the experimentally observed spectral features is the result of different local interactions of d- and l-alanine with permethylated β-cyclodextrin...
May 25, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28540778/ex-vivo-optimisation-of-a-heterogeneous-speed-of-sound-model-of-the-human-skull-for-non-invasive-transcranial-focused-ultrasound-at-1%C3%A2-mhz
#19
L Marsac, D Chauvet, R La Greca, A-L Boch, K Chaumoitre, M Tanter, J-F Aubry
Transcranial brain therapy has recently emerged as a non-invasive strategy for the treatment of various neurological diseases, such as essential tremor or neurogenic pain. However, treatments require millimetre-scale accuracy. The use of high frequencies (typically ≥1 MHz) decreases the ultrasonic wavelength to the millimetre scale, thereby increasing the clinical accuracy and lowering the probability of cavitation, which improves the safety of the technique compared with the use of low-frequency devices that operate at 220 kHz...
March 7, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28540544/five-year-volume-growth-of-european-beech-does-not-respond-to-ozone-pollution-in-italy
#20
Elena Paoletti, Alessandra De Marco, Alessandro Anav, Patrizia Gasparini, Enrico Pompei
A unique database of stand volume growth, estimated as periodic annual volume increment (in m(3) ha(-1) per year over the period 2001-2005) from 728 European beech (Fagus sylvatica L.) sites distributed across Italy, was used to assess the effects of ambient ozone (O3), expressed as annual average (M24), accumulated exposure above a 40 ppb hourly threshold (AOT40), and total stomatal ozone flux (POD0). Growth data were from the National forest inventory of Italy, while climate data and ozone concentrations were computed by the WRF and CHIMERE models, respectively...
May 24, 2017: Environmental Science and Pollution Research International
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