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https://www.readbyqxmd.com/read/28647837/targeting-metabolic-reprogramming-in-kras-driven-cancers
#1
REVIEW
Kenji Kawada, Kosuke Toda, Yoshiharu Sakai
Mutations of KRAS are found in a variety of human malignancies, including in pancreatic cancer, colorectal cancer, and non-small cell lung cancer at high frequency. To date, no effective treatments that target mutant variants of KRAS have been introduced into clinical practice. In recent years, a number of studies have shown that the oncogene KRAS plays a critical role in controlling cancer metabolism by orchestrating multiple metabolic changes. One of the metabolic hallmarks of malignant tumor cells is their dependency on aerobic glycolysis, known as the Warburg effect...
June 24, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28647671/use-of-oncogenic-driver-mutations-in-staging-of-multiple-primary-lung-carcinomas-a-single-center-experience
#2
Ramsey Asmar, Joshua R Sonett, Gopal Singh, Mahesh M Mansukhani, Alain C Borczuk
PURPOSE: The staging of multiple pulmonary adenocarcinomas requires the distinction of intrapulmonary metastasis (IPM) from multiple primary lung cancers (MPLC). This can be challenging in some patients, and the addition of data from oncogenic driver mutations in these tumors may be helpful in this determination. PROCEDURES: As a proof of principle, molecular driver results from primary tumors and their metastases in 45 patients were compared (cohort 1). Then, 69 patients with a total of 154 synchronous or metachronous lung carcinomas were identified, with pathologic findings compared to oncogenic driver mutation...
June 21, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28647430/determining-the-relevant-criteria-for-three-dimensional-vocal-tract-characterization
#3
Rebecca R Vos, Damian T Murphy, David M Howard, Helena Daffern
OBJECTIVE: Soprano singers face a number of specific challenges when singing vowels at high frequencies, due to the wide spacing of harmonics in the voice source. The varied and complex techniques used to overcome these are still not fully understood. Magnetic resonance imaging (MRI) has become increasingly popular in recent years for singing voice analysis. This study proposes a new protocol using three-dimensional MRI to investigate the articulatory parameters relevant to resonance tuning, a technique whereby singers alter their vocal tract to shift its resonances nearer to a voice source harmonic, increasing the amplitude of the sound produced...
June 21, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28646826/comparison-of-brca1-expression-between-triple-negative-and-luminal-breast-tumors
#4
Farzaneh Darbeheshti, Pantea Izadi, Amir Nader Emami Razavi, Mir Saeed Yekaninejad, Javad Tavakkoly Bazzaz
Background: Previous studies have suggested that BRCA1 dysregulation has a role in triple-negative phenotypic manifestation. However, differences of BRCA1 expression, as a tumor suppressor gene, have rarely been investigated between luminal and triple-negative breast tumors. Therefore, the present study attempted to compare the BRCA1 expression in triple-negative with luminal breast tumors and its association with the clinicopathologic characteristics of patients. Methods: BRCA1 expression was evaluated by real-time PCR in 26 triple-negative and 27 luminal breast tumors...
June 25, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28646783/heart-rate-variability-in-patients-with-major-depression-disorder-during-a-clinical-autonomic-test
#5
Xiuwen Chen, Rongqian Yang, Danni Kuang, Lei Zhang, Ruixue Lv, Xiong Huang, Fengchun Wu, Guohui Lao, Shanxing Ou
Major depression disorder (MDD) patients express dysfunction autonomic nervous system (ANS) and reduced heart rate variability (HRV). However, previous researches mainly focused on examining resting state without considering a series of stimulation tests of ANS between MDD patients and healthy people. For this purpose, 40 healthy people and 40 MDD patients participated and finished 10min clinical autonomic test-Ewing test. Parameters of HRV such as time domain, frequency domain, and nonlinear dynamical parameters were calculated...
June 14, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28646419/repetition-blindness-in-priming-in-perceptual-identification-competitive-effects-of-a-word-intervening-between-prime-and-target
#6
Jennifer S Burt, Jessica Jolley
University students named a 72-ms masked target word that was preceded by two 120-ms consecutively presented words, a prime word followed by a distractor. In Experiment 1, all words were in lowercase letters, whereas in Experiment 2, the target word was changed to uppercase letters. In both experiments there was an accuracy and latency cost (repetition blindness: RB) when the prime was the same word as the target, with the cost much less severe in Experiment 2 than in Experiment 1. A low-frequency distractor impaired target identification compared with a high-frequency distractor...
June 23, 2017: Memory & Cognition
https://www.readbyqxmd.com/read/28646367/ifn%C3%AE-producing-cd4-t-lymphocytes-the-double-edged-swords-in-tuberculosis
#7
Pawan Kumar
IFNγ-producing CD4(+) T cells (IFNγ(+)CD4(+) T cells) are the key orchestrators of protective immunity against Mycobacterium tuberculosis (Mtb). Primarily, these cells act by enabling Mtb-infected macrophages to enforce phagosome-lysosome fusion, produce reactive nitrogen intermediates (RNIs), and activate autophagy pathways. However, TB is a heterogeneous disease and a host of clinical and experimental findings has also implicated IFNγ(+)CD4(+) T cells in TB pathogenesis. High frequency of IFNγ(+)CD4(+) T cells is the most invariable feature of the active disease...
December 2017: Clinical and Translational Medicine
https://www.readbyqxmd.com/read/28646006/high-frequency-jet-ventilation-in-preterm-infants-is-there-still-room-for-it
#8
EDITORIAL
Mário Ferreira Carpi
No abstract text is available yet for this article.
July 2017: Respiratory Care
https://www.readbyqxmd.com/read/28644911/interictal-oscillations-and-focal-epileptic-disorders
#9
Maxime Lévesque, Pariya Salami, Zahra Shiri, Massimo Avoli
Neuronal network oscillations represent a main feature of the brain activity recorded in the EEG under normal and pathological conditions such as epilepsy. Specific oscillations occur between seizures in patients and in animal models of focal epilepsy, and thus they are termed interictal. According to their shape and intrinsic signal frequency, interictal oscillations are classified as spikes and high frequency oscillations (HFOs). Interictal spikes are recorded in the "wideband" EEG signal and consist of large-amplitude events that usually last less than 1 s; HFOs, in contrast, are extracted by amplifying the appropriately filtered EEG signal, and are usually categorized as ripples (80-200 Hz) and fast ripples (250-500 Hz)...
June 23, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28644037/lower-risk-cannabis-use-guidelines-a-comprehensive-update-of-evidence-and-recommendations
#10
Benedikt Fischer, Cayley Russell, Pamela Sabioni, Wim van den Brink, Bernard Le Foll, Wayne Hall, Jürgen Rehm, Robin Room
BACKGROUND: Cannabis use is common in North America, especially among young people, and is associated with a risk of various acute and chronic adverse health outcomes. Cannabis control regimes are evolving, for example toward a national legalization policy in Canada, with the aim to improve public health, and thus require evidence-based interventions. As cannabis-related health outcomes may be influenced by behaviors that are modifiable by the user, evidence-based Lower-Risk Cannabis Use Guidelines (LRCUG)-akin to similar guidelines in other health fields-offer a valuable, targeted prevention tool to improve public health outcomes...
June 23, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28643918/effect-of-cyclical-forces-on-orthodontic-tooth-movement-from%C3%A2-animals-to-humans
#11
REVIEW
F Uribe, E Dutra, T Chandhoke
Vibration as a non-invasive method is currently available for clinical use with the potential to accelerate the rate of tooth movement in orthodontics. The aim of this review was to evaluate the basic science and clinical literature on the effects of vibration on the axial and appendicular skeleton including the craniofacial bone. Vibration as a dynamic load consisting of high oscillatory forces of low magnitude has shown osteogenic and anti-catabolic effects on bone. These effects have been observed in the craniofacial skeleton including the alveolar bone as increases in sutural width and alveolar bone formation...
June 2017: Orthodontics & Craniofacial Research
https://www.readbyqxmd.com/read/28643891/direct-comparison-of-high-temporal-resolution-cine-mri-with-doppler-ultrasound-for-assessment-of-diastolic-dysfunction-in-mice
#12
Thomas A Roberts, Anthony N Price, Laurence H Jackson, Valerie Taylor, Anna L David, Mark F Lythgoe, Daniel J Stuckey
Diastolic dysfunction is a sensitive early indicator of heart failure and can provide additional data to conventional measures of systolic function. Transmitral Doppler ultrasound, which measures the one-dimensional flow of blood through the mitral valve, is currently the preferred method for the measurement of diastolic function, but the measurement of the left ventricular volume changes using high-temporal-resolution cinematic magnetic resonance imaging (CINE MRI) is an alternative approach which is emerging as a potentially more robust and user-independent technique...
June 23, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28643786/a-unified-model-of-hymenopteran-preadaptations-that-trigger-the-evolutionary-transition-to-eusociality
#13
Andrés E Quiñones, Ido Pen
Explaining the origin of eusociality, with strict division of labour between workers and reproductives, remains one of evolutionary biology's greatest challenges. Specific combinations of genetic, behavioural and demographic traits in Hymenoptera are thought to explain their relatively high frequency of eusociality, but quantitative models integrating such preadaptations are lacking. Here we use mathematical models to show that the joint evolution of helping behaviour and maternal sex ratio adjustment can synergistically trigger both a behavioural change from solitary to eusocial breeding, and a demographic change from a life cycle with two reproductive broods to a life cycle in which an unmated cohort of female workers precedes a final generation of dispersing reproductives...
June 23, 2017: Nature Communications
https://www.readbyqxmd.com/read/28643460/periodic-limb-movement-in-sleep-and-sickle-cell-disease-a-neglected-association
#14
Ana C Cabañas-Pedro, Suely Roizenblatt, Altay A L de Souza, Sérgio Tufik, Maria S Figueiredo
High frequency of periodic limb movements in sleep (PLMS) has been described among children with sickle cell disease (SCD), but there is little information about PLMS among adults with SCD. We aim to determine the frequency of PLMS among adults with SCD and to identify possible associations with iron status and haemolytic parameters. We analysed polysomnography on 99 adults: 74 with sickle cell anaemia (HbSS), 19 with HbSC (double heterozygosis HbS and HbC) and 6 with HbS-beta thalassaemia. Laboratory data were collected close to the time of the polysomnography examination...
June 23, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28643177/targeting-dna-repair-and-replication-stress-in-the-treatment-of-ovarian-cancer
#15
REVIEW
Junko Murai
Approximately half of high-grade serous epithelial ovarian cancers incur alterations in genes of homologous recombination (BRCA1, BRCA2, RAD51C, Fanconi anemia genes), and the rest incur alterations in other DNA repair pathways at high frequencies. Such cancer-specific gene alterations can confer selective sensitivity to DNA damaging agents such as cisplatin and carboplatin, topotecan, etoposide, doxorubicin, and gemcitabine. Originally presumed to inhibit DNA repair, PARP inhibitors that have recently been approved by the FDA for the treatment of advanced ovarian cancer also act as DNA damaging agents by inducing PARP-DNA complexes...
June 22, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28642996/central-conduction-abnormalities-in-patients-receiving-levodopa-carbidopa-intestinal-gel-infusion
#16
Francesco Bove, Marco Luigetti, Lara Gallicchio, Valentina Recchia, Antonella Petruzzellis, Riccardo Di Iorio, Filippo Tamma, Alfonso Fasano
In recent years, several studies have reported a relatively high frequency of polyneuropathy in patients with Parkinson's disease (PD), in particular, in patients receiving levodopa-carbidopa intestinal gel (LCIG) infusion. In spite of the several patients investigated with nerve conduction studies, no study has prospectively explored a possible central nervous system involvement of patients receiving LCIG infusion. We prospectively evaluated eight PD patients receiving LCIG infusion, who underwent neurophysiological evaluations with nerve conduction studies, visual, somatosensory and motor evoked potentials before LCIG infusion, and 1 and 6 months after...
June 22, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28642497/interactive-effects-of-plant-neighbourhood-and-ontogeny-on-insect-herbivory-and-plant-defensive-traits
#17
Xoaquín Moreira, Gaétan Glauser, Luis Abdala-Roberts
Plant ontogenetic stage and features of surrounding plant neighbourhoods can strongly influence herbivory and defences on focal plants. However, the effects of both factors have been assessed independently in previous studies. Here we tested for the independent and interactive effects of neighbourhood type (low vs. high frequency of our focal plant species in heterospecific stands) and ontogeny on leaf herbivory, physical traits and chemical defences of the English oak Quercus robur. We further tested whether plant traits were associated with neighbourhood and ontogenetic effects on herbivory...
June 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28642292/frequency-and-magnitude-of-intermittent-hypoxia-modulate-endothelial-wound-healing-in-a-cell-culture-model-of-sleep-apnea
#18
Noelia Campillo, Bryan Falcones, Josep M Montserrat, David Gozal, Ana Obeso, Teresa Gallego-Martin, Daniel Navajas, Isaac Almendros, Ramon Farre
Intermittent hypoxia (IH) has been implicated in the cardiovascular consequences of obstructive sleep apnea (OSA). However, the lack of suitable experimental systems has precluded assessment as to whether IH is detrimental, protective or both for the endothelium. The aim of the work was to determine the effects of frequency and amplitude of IH oxygenation swings on aortic endothelial wound healing. Monolayers of human primary endothelial cells were wounded, and subjected to constant oxygenation (1%, 4%, 13% or 20% O2) or IH at different frequencies (0...
June 22, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28641639/-clinical-features-and-response-to-treatment-in-newly-diagnosed-multiple-myeloma-patients-with-deletion-17p
#19
Yan Liu, Xiao-Yan Ke, Jing Wang, Yan-Fang Wang, Fei Dong, Lei Tian, Wei Wan, Hong-Mei Jing
OBJECTIVE: To investigate the clinical features and response to therapies in multiple myeloma (MM) patients with del (17p). METHODS: A total of 122 newly diagnosed MM patients hospitalized in the Department of Hematology of Peking University Third Hospital between October 2012 and September 2016 were analyzed retrospectively. The fluorescent in situ hybridization(FISH) and G-binding staining were used for detection of cytogenetic abnormalities. These MM patients with del (17p) were divided into non-bortezomib chemotherapy (VAD or CHOP) group and bortezomib chemotherapy (PAD or PCD) group...
June 2017: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/28641289/impact-of-comorbid-irritable-bowel-syndrome-on-treatment-outcome-in-non-erosive-reflux-disease-on-long-term-proton-pump-inhibitor-in-japan
#20
Yasushi Funaki, Hiroshi Kaneko, Yurika Kawamura, Takashi Yoshimine, Yasuhiro Tamura, Shinya Izawa, Masahide Ebi, Naotaka Ogasawara, Makoto Sasaki, Kunio Kasugai
BACKGROUND/AIMS: Irritable bowel syndrome (IBS) frequently coexists with non-erosive reflux disease (NERD). Efficacy of long-term proton pump inhibitor (PPI) treatment on NERD with or without IBS is controversial. The impact of comorbid IBS in NERD on quality of life (QOL) remains uncertain. We verified the hypothesis that NERD patients with IBS symptoms demonstrated poor responses to long-term PPI treatments, deteriorated QOL, and high frequency of psychological deviations in Japan. METHODS: In all, 141 NERD patients who had been taking PPIs for more than 6 months were enrolled and analyzed...
June 23, 2017: Digestion
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