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Cardiac pregnancy

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https://www.readbyqxmd.com/read/28101770/factors-controlling-fetal-echocardiography-determine-the-diagnostic-accuracy-of-isolated-ventricular-septal-defect
#1
Jiao Chen, Liang Xie, Han-Min Liu
BACKGROUND: Fetal echocardiography (FECG) is a key screening tool for prenatal cardiac abnormalities. Herein, we examined the ultrasonic factors determining prenatal ultrasonic diagnosis of isolated ventricular septal defect (IVSD). METHODS: The diagnostic role of ultrasonic factors was investigated in patients in middle or late pregnancy, diagnosed with IVSD by FECG and confirmed using postnatal echocardiography. RESULTS: One hundred and six patients with IVSD were enrolled; the majority had perimembranous VSD...
January 19, 2017: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/28100569/multiple-pregnancy-in-a-primigravida-with-uncorrected-pentalogy-of-fallot
#2
Pamela Partana, Jarrod Kah Hwee Tan, Ju Le Tan, Lay Kok Tan
Pentalogy of Fallot is a cyanotic congenital heart disease that has guarded prognosis without surgical intervention in infancy. Women with uncorrected defects rarely survive into childbearing age and pregnancy in this group is associated with a high rate of perinatal loss. Physiological cardiovascular changes in pregnancy can lead to maternal haemodynamic instability with subsequent adverse cardiac sequelae with or without fetal decompensation. Optimum management and pregnancy outcomes in mother with uncorrected Pentalogy of Fallot and twin pregnancy have not been described in the literature...
January 18, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28099709/preliminary-study-of-the-effects-of-furosemide-on-blood-pressure-during-late-onset-pre-eclampsia-in-patients-with-high%C3%A2-cardiac-output
#3
Péter Tamás, Eszter Hantosi, Bálint Farkas, Zsolt Ifi, József Betlehem, József Bódis
OBJECTIVE: To examine the effect of furosemide on hypertension and edema in patients with pre-eclampsia experiencing high cardiac output. METHODS: The present cohort study enrolled patients with pre-eclampsia who were admitted to the pregnancy pathology unit of the Department of Obstetrics and Gynecology, University of Pécs, Hungary, between January 1 and December 31, 2015. Eligible patients had singleton pregnancies with no fetal anomalies, high blood volume, visible edema, and a hematocrit concentration below 37 L/L...
January 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28094006/salt-aldosterone-and-extrarenal-na-sensitive-responses-in-pregnancy
#4
Paula Juliet Scaife, Markus Georg Mohaupt
Outside of pregnancy excessive salt consumption is known to be harmful being linked to increased blood pressure and cardiovascular disease. However, pregnancy represents a major change to a woman's physiology resulting in an intimate adaptation to environmental conditions. It is now becoming apparent that salt is essential for a number of these changes during pregnancy including haematological, cardiac adaptations as well as directly influencing placental development and the uteroplacental immune environment...
January 10, 2017: Placenta
https://www.readbyqxmd.com/read/28089575/association-of-uterine-fibroids-and-pregnancy-outcomes-after-ovarian-stimulation-intrauterine-insemination-for-unexplained-infertility
#5
Aaron K Styer, Susan Jin, Dan Liu, Baisong Wang, Alex J Polotsky, Mindy S Christianson, Wendy Vitek, Lawrence Engmann, Karl Hansen, Robert Wild, Richard S Legro, Christos Coutifaris, Ruben Alvero, Randal D Robinson, Peter Casson, Gregory M Christman, Alicia Christy, Michael P Diamond, Esther Eisenberg, Heping Zhang, Nanette Santoro
OBJECTIVE: To investigate the association of non-cavity-distorting uterine fibroids and pregnancy outcomes after ovarian stimulation-intrauterine insemination (OS-IUI) in couples with unexplained infertility. DESIGN: Secondary analysis from a prospective, randomized, multicenter clinical trial investigating fertility outcomes after OS-IUI. SETTING: Reproductive Medicine Network clinical sites. PATIENT(S): Nine hundred couples with unexplained infertility who participated in the Assessment of Multiple Intrauterine Gestations from Ovarian Stimulation (AMIGOS) clinical trial...
January 12, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28079767/primary-gastric-choriocarcinoma-presenting-as-a-pregnancy-of-unknown-location
#6
Alyssa Larish, Amanika Kumar, Sarah Kerr, Carrie Langstraat
BACKGROUND: Pregnancy of unknown location presents a diagnostic challenge, in rare occasions leading to the diagnosis of malignancy. We describe a case of β-hCG-secreting nongestational primary gastric choriocarcinoma presenting as a pregnancy of unknown location. CASE: A 37-year-old woman, gravida 4 para 3013, presented with several days of vaginal bleeding and rising β-hCG level without ultrasound localization of pregnancy. The diagnosis of pregnancy of unknown location was made and methotrexate administered at a β-hCG level of 7,779 milli-international units/mL...
January 9, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28079556/cardiac-arrest-obstetric-cpr-acls
#7
Benjamin Cobb, Steven Lipman
In contrast with other high-resource countries, maternal mortality has seen an increase in the United States. Caring for pregnant women in cardiac arrest may prove uniquely challenging given the rarity of the event coupled by the physiological changes of pregnancy. Optimization of resuscitative efforts warrants special attention as described in the 2015 American Heart Association's "Scientific Statement on Maternal Cardiac Arrest." Current recommendations address a variety of topics ranging from the basic components of chest compressions and airway management to some of the logistical complexities and operational challenges involved in maternal cardiac arrest...
January 10, 2017: Clinical Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28078751/cardiac-remodelling-during-normotensive-and-hypertensive-complicated-pregnancies-a-systematic-review-and-meta-analysis
#8
REVIEW
Sander de Haas, Chahinda Ghossein-Doha, Lauren Geerts, Sander Mj van Kuijk, Joris van Drongelen, Marc Ea Spaanderman
OBJECTIVE: The aim of this systematic review and meta-analyses was to comprehensively describe the normotensive pattern of cardiac remodelling during human singleton pregnancies and compared to that during hypertensive complicated pregnancies. METHODS: We performed a meta-analysis of the current literature on cardiac remodelling during normotensive and complicated pregnancies. Literature was retrieved from PubMed (NCBI) and Embase (Ovid) databases. Included studies needed to report a reference measurement (matched non-pregnant control group, pre-pregnancy, or post-partum) and measurements during a predetermined gestational interval...
January 12, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28076990/outcomes-in-the-absence-of-the-ductus-venosus-diagnosed-in-the-first-trimester
#9
Hiroko Takita, Junichi Hasegawa, Tatsuya Arakaki, Shoko Hamada, Mayumi Tokunaka, Masamitsu Nakamura, Ryu Matsuoka, Akihiko Sekizawa
PURPOSE: To clarify the outcomes of the absence of the ductus venosus diagnosed in fetuses suspected to have a structural abnormality during a morphological assessment in the first trimester. METHODS: Infants in whom ultrasound fetal morphological assessments were attempted in the first trimester (11 to 13-6 weeks of gestation) and who were subsequently delivered between 2013 and 2015 at Showa University Hospital were enrolled. In cases in which the absence of the ductus venosus was diagnosed in the first trimester, the prognosis was assessed...
January 11, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28056970/inhibition-of-histone-acetylation-by-curcumin-reduces-alcohol-induced-fetal-cardiac-apoptosis
#10
Xiaochen Yan, Bo Pan, Tiewei Lv, Lingjuan Liu, Jing Zhu, Wen Shen, Xupei Huang, Jie Tian
BACKGROUND: Prenatal alcohol exposure may cause cardiac development defects, however, the underlying mechanisms are not yet clear. In the present study we have investigated the roles of histone modification by curcumin on alcohol induced fetal cardiac abnormalities during the development. METHODS AND RESULTS: Q-PCR and Western blot results showed that alcohol exposure increased gene and active forms of caspase-3 and caspase-8, while decreased gene and protein of bcl-2...
January 5, 2017: Journal of Biomedical Science
https://www.readbyqxmd.com/read/28049534/case-report-maternal-mosaicism-resulting-in-inheritance-of-a-novel-gata6-mutation-causing-pancreatic-agenesis-and-neonatal-diabetes-mellitus
#11
Daphne Yau, Elisa De Franco, Sarah E Flanagan, Sian Ellard, Miriam Blumenkrantz, John J Mitchell
BACKGROUND: Haploinsufficiency of the GATA6 transcription factor gene was recently found to be the most common cause of pancreatic agenesis, a rare cause of neonatal diabetes mellitus. Although most cases are de novo, we describe three siblings with inherited GATA6 haploinsufficiency and the rare finding of parental mosaicism. CASE PRESENTATION: The proband was born at term with severe intrauterine growth restriction, the first child of non-consanguineous parents...
January 3, 2017: Diagnostic Pathology
https://www.readbyqxmd.com/read/28046063/three-dimensional-high-frequency-ultrasonography-for-early-detection-and-characterization-of-embryo-implantation-site-development-in-the-mouse
#12
Mary C Peavey, Corey L Reynolds, Maria M Szwarc, William E Gibbons, Cecilia T Valdes, Francesco J DeMayo, John P Lydon
Ultrasonography is a powerful tool to non-invasively monitor in real time the development of the human fetus in utero. Although genetically engineered mice have served as valuable in vivo models to study both embryo implantation and pregnancy progression, such studies usually require sacrifice of parous mice for subsequent phenotypic analysis. To address this issue, we used three-dimensional (3-D) reconstruction in silico of high-frequency ultrasound (HFUS) imaging data for early detection and characterization of murine embryo implantation sites and their development in utero...
2017: PloS One
https://www.readbyqxmd.com/read/28045917/impact-of-pregestational-weight-and-weight-gain-during-pregnancy-on-long-term-risk-for-diseases
#13
Ulrika Moll, Håkan Olsson, Mona Landin-Olsson
OBJECTIVE: The aim of this study was to analyse the impact of maternal BMI at start of pregnancy and maternal weight gain during pregnancy on the risk of various diseases later in life. METHODS: In a population-based cohort from southern Sweden, women with at least one delivery registered in the Swedish Medical Birth Register ten or more years before answering a health questionnaire were identified (n = 13,608). Complete data were found in 3,539 women. RESULTS: Women with BMI >25 at start of pregnancy had increased risk of developing obesity (OR 21...
2017: PloS One
https://www.readbyqxmd.com/read/28032463/developmental-toxicity-studies-of-lumefantrine-and-artemether-in-rats-and-rabbits
#14
Robert L Clark, Maureen Youreneff, Anthony M DeLise
The combination of artemether plus lumefantrine is a type of artemisinin-based combination therapy (ACT) recommended by the World Health Organization for uncomplicated falciparum malaria except in the first trimester of pregnancy. The first trimester restriction was based on the marked embryotoxicity in animals (including embryo death and cardiac and skeletal malformations) of artemisinins such as artesunate, dihydroartemisinin, and artemether. Before recommending ACTs for use in the first trimester, the World Health Organization has requested that all information relevant to the assessment of risk of ACTs to the embryo be made available to the public...
December 2016: Birth Defects Research. Part B, Developmental and Reproductive Toxicology
https://www.readbyqxmd.com/read/28029641/angiogenic-imbalance-and-residual-myocardial-injury-in-recovered-peripartum-cardiomyopathy-patients
#15
Sorel Goland, Jean Marc Weinstein, Adi Zalik, Rafael Kuperstein, Liaz Zilberman, Sara Shimoni, Michael Arad, Tuvia Ben Gal, Jacob George
BACKGROUND: Recent studies suggest that angiogenic imbalance during pregnancy may lead to acute peripartum cardiomyopathy (PPCM). We propose that angiogenic imbalance and residual cardiac dysfunction may exist even after recovery from PPCM. METHODS AND RESULTS: Twenty-nine women at least 12 months after presentation with PPCM, who exhibited recovery of left ventricular (LV) ejection fraction (≥50%), were included in the study (mean age 35±6 years, LV ejection fraction 61...
November 2016: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28029179/prenatal-diagnosis-of-congenital-heart-diseases-by-fetal-echocardiography-in-second-trimester-a-chinese-multicenter-study
#16
Chen Chu, Yingliu Yan, Yunyun Ren, Xiaotian Li, Yonghao Gui
INTRODUCTION: The objective of our study was to evaluate the performance of detailed fetal echocardiography by skilled obstetric physician sonologists in the diagnosis of congenital heart disease (CHD) in a Chinese population. MATERIAL AND METHODS: This investigation included a multicenter prospective cohort of 10,259 pregnant women attending ten regional tertiary hospitals in China. The inclusion criteria were singleton pregnancy and gestational age 18 ~ ≤28 weeks...
December 28, 2016: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28017511/out-of-hospital-cardiac-arrest-in-pregnancy-with-good-neurological-outcome-for-mother-and-infant
#17
S Pecher, E Williams
Cardiac arrest in pregnancy is rare (about 1:30000 pregnancies) and out-of-hospital cardiac arrests are even less frequent. Resuscitation of the pregnant mother is challenging and requires attention to the altered physiology, specific pathologies and the presence and well-being of the fetus. Once circulation has been restored, the lack of high-grade evidence regarding delivery of the baby and post-resuscitation care makes decision making complex. We present a case of out-of-hospital maternal cardiac arrest with successful resuscitation and good neurological outcome for mother and infant...
November 15, 2016: International Journal of Obstetric Anesthesia
https://www.readbyqxmd.com/read/28006009/mode-of-delivery-and-pregnancy-outcome-in-women-with-congenital-heart-disease
#18
Joris Hrycyk, Harald Kaemmerer, Nicole Nagdyman, Moritz Hamann, Ktm Schneider, Bettina Kuschel
BACKGROUND: Advances in cardiac surgery and congenital cardiology have led to an increasing number of women with congenital heart disease (CHD) reaching childbearing age. In general, cardiologists recommend vaginal delivery for women with CHD to avoid complications from Caesarean section as many women with CHD tolerate vaginal delivery well. METHODS AND RESULTS: This is a single-center study comparing mode of delivery, pregnancy outcome, indications for Caesarean section and induction of labor between women with and without CHD...
2016: PloS One
https://www.readbyqxmd.com/read/28005594/controversies-regarding-diagnosis-and-treatment-of-severe-hypertension-in-pregnancy
#19
John R Barton, Baha M Sibai
The objective of management of severe hypertension in pregnancy is not for the return of normal blood pressure but rather reduction of blood pressure to a level associated with a decreased risk of end-organ damage including cerebral, cardiac, or renal dysfunction. The parenteral agents labetalol and hydralazine are currently the most widely recommended antihypertensive agents for acute reductions of elevated blood pressure related to preeclampsia. Overcorrection of blood pressure with any antihypertensive agent is possible resulting in reduced uteroplacental blood flow, but is more likely to be encountered in patients <32 weeks' gestation and in those whose fetuses have intrauterine growth retardation...
December 21, 2016: Clinical Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28005501/imaging-of-heart-disease-in-women
#20
Tina D Tailor, Gregory A Kicska, Jill E Jacobs, Miguel H Pampaloni, Diana E Litmanovich, Gautham P Reddy
Ischemic heart disease is the number one cause of death of women in the United States, accounting for over a quarter of a million annual female deaths. Evidence within the last several decades supports sex-specific differences in the prevalence, symptoms, and prognosis of ischemic heart disease between men and women. Despite women having a lower burden of obstructive coronary artery disease compared with men, the prevalence of angina and mortality from ischemic heart disease is higher for women than men. In addition to ischemic heart disease, certain nonischemic conditions may also have sex-specific differences in clinical presentation and occurrence...
January 2017: Radiology
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