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"Cirrhosis decompensated"

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https://www.readbyqxmd.com/read/27882182/disease-progression-in-chinese-patients-with-hepatitis-c-virus-rna-positive-infection-via-blood-transfusion
#1
Yan-Feng Pan, Yan Zheng, Tao Qin, Lei Feng, Qian Zhang, Xiao-Gong Ping, Yan-Ting Pan, Xiao-Ping Wang, Li Bai, Hua-Hua Li
The majority of patients with hepatitis C virus (HCV) in China were infected via blood transfusion prior to the year 1996. In this systematic retrospective cohort study, disease progression in 804 consecutive patients with transfusion-acquired HCV is investigated. In addition, the occurrence of compensated cirrhosis, decompensated cirrhosis and hepatocellular carcinoma (HCC) is analyzed among these patients, along with the risk factors for disease progression. Patients with cirrhosis or HCC were classified as the serious development group (SD group) and the remaining patients with chronic hepatitis were classified as the hepatitis group (H group)...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27869323/comparative-treatment-effectiveness-of-direct-acting-antiviral-regimens-for-hepatitis-c-data-from-the-veterans-administration
#2
D S Fox, J J McGinnis, I Tonnu-Mihara, J S McCombs
BACKGROUND AND AIMS: Data addressing real world effectiveness of direct acting antiviral agents in hepatitis C infected patients are now emerging. This study compared the sustained virologic response rates achieved 12 weeks post-treatment in patients treated with three such agents by the Veterans Health Administration. METHODS: A retrospective cohort study was conducted using patients who terminated treatment by July 1, 2015. Data were retrieved from the Veterans Health Administration electronic medical records system...
November 21, 2016: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27809664/liver-surface-nodularity-score-allows-prediction-of-cirrhosis-decompensation-and-death
#3
Andrew D Smith, Kevin A Zand, Edward Florez, Reza Sirous, Darya Shlapak, Frederico Souza, Manohar Roda, Jason Bryan, Amit Vasanji, Michael Griswold, Seth T Lirette
Purpose To determine whether use of the liver surface nodularity (LSN) score, a quantitative biomarker derived from routine computed tomographic (CT) images, allows prediction of cirrhosis decompensation and death. Materials and Methods For this institutional review board-approved HIPAA-compliant retrospective study, adult patients with cirrhosis and Model for End-Stage Liver Disease (MELD) score within 3 months of initial liver CT imaging between January 3, 2006, and May 30, 2012, were identified from electronic medical records (n = 830)...
November 3, 2016: Radiology
https://www.readbyqxmd.com/read/27759643/epidemiological-burden-estimates-for-pathologies-with-a-nonconstant-risk-an-application-to-hcv-in-italy-according-to-age-metavir-score-and-genotype-a-systematic-review-and-meta-analysis
#4
Rossella Letizia Mancusi, Massimo Andreoni, Daniela d'Angela, Cesare Sarrecchia, Federico Spandonaro
Between western European countries, the hepatitis C virus (HCV) endemic is highest in Italy. The main objective of this paper is to estimate the endemic diffusion of hepatitis C at the national level and by geographical area, with an extrapolation at the regional level and by uniform cohorts of subjects (by sex and year of birth). The secondary objective is a stratification by gravity of the estimated statistical figures to provide an overview of possible targets of the new anti-HCV treatments.PubMed and the Cochrane Library were searched for relevant Italian populations studies regarding HCV prevalence...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27583874/the-clinical-outcomes-of-chronic-hepatitis-c-in-south-korea-a-prospective-multicenter-cohort-study
#5
Kyeong Sam Ok, Sook-Hyang Jeong, Eun Sun Jang, Young Seok Kim, Youn Jae Lee, In Hee Kim, Sung Bum Cho, Si Hyun Bae, Han Chu Lee
This prospective cohort study aimed to elucidate the clinical outcome and its related factors of chronic hepatitis C in a hepatitis B-dominant Asian region.From January 2007 to October 2012, 382 patients with chronic hepatitis C without liver cirrhosis were prospectively enrolled at 6 university hospitals, and regularly followed until Apr 2014 to identify the development of liver cirrhosis, decompensated cirrhosis, hepatocellular carcinoma (HCC), and overall survival.During the median follow-up of 39.0 months (range 18...
August 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27350940/interferon-free-treatments-for-chronic-hepatitis-c-genotype-1-infection
#6
REVIEW
Alireza FakhriRavari, Mazyar Malakouti, Rebecca Brady
Hepatitis C virus (HCV) infection affects as many as 185 million people globally, many of whom are chronically infected and progress over time to cirrhosis, decompensated liver disease, hepatocellular carcinoma, and eventually death without a liver transplant. In the United States, HCV genotype 1 constitutes about 75% of all infections. While interferon and ribavirin therapy was the cornerstone of treatment for many years, interferon-free treatments have become the standard of care with the emergence of new direct-acting agents, resulting in more effective treatment, shorter duration of therapy, better tolerability, lower pill burden, and ultimately better adherence...
June 28, 2016: Journal of Clinical and Translational Hepatology
https://www.readbyqxmd.com/read/27342742/cost-effectiveness-of-genotype-1-chronic-hepatitis-c-virus-treatments-in-patients-coinfected-with-human-immunodeficiency-virus-in-the-united-states
#7
Sammy Saab, Suchin Virabhak, Hélène Parisé, Scott Johnson, Alice Wang, Derek Misurski, Yuri Sanchez Gonzalez, Timothy Juday
INTRODUCTION: New treatments for chronic hepatitis C virus (HCV) are highly effective in patients coinfected with human immunodeficiency virus (HIV). This study estimated the cost-effectiveness of treatments for genotype 1 (GT1) HCV in HIV-coinfected patients. METHODS: A Markov model based on HCV natural history was used. The base-case analysis included both treatment-naïve and -experienced patients. Alternatives were ombitasvir/paritaprevir/ritonavir, dasabuvir with or without ribavirin (3D ± R) for 12 or 24 weeks, sofosbuvir plus peginterferon and R (SOF + PR) for 12 weeks, SOF + R for 24 weeks, and no treatment (NT)...
August 2016: Advances in Therapy
https://www.readbyqxmd.com/read/27088788/-evaluation-and-treatment-of-portal-hypertension
#8
Radan Brůha, Jaromír Petrtýl
Liver cirrhosis is a serious disease shortening the life expectancy. Unavoidable consequence of cirrhosis is portal hypertension, which usually limits the prognosis by its complications. Portal hypertension is a prognostic factor for cirrhosis decompensation, variceal bleeding and even the mortality in cirrhotic patients. In the evaluation of portal hypertension hepatic venous pressure gradient (HVPG) measurement is used.Measurement of HVPG is used in clinical praxis in these situations: diagnosis of portal hypertension, evaluation of prognosis of patients with cirrhosis, monitoring the treatment efficacy in the prevention of variceal bleeding, management of acute variceal bleeding...
2016: Casopís Lékar̆ů C̆eských
https://www.readbyqxmd.com/read/27014763/isolated-gastric-varices-and-use-of-balloon-occlusive-retrograde-transvenous-obliteration-a-case-report-and-literature-review
#9
Thomas R McCarty, Mena Bakhit, Tarun Rustagi
Isolated gastric varices are far less prevalent in Western countries where the rate of splenic thrombosis is much lower. However, in Asian countries the entity is more common and therefore a more robust treatment approach has been developed. Balloon-occlusive retrograde transvenous obliteration (BRTO) was first described in 1984 and then revived in 1996. The procedure, while uncommon in the U.S. and not recognized by the AASLD practice guidelines, allows for direct exclusion from the portosystemic system. Here we describe the case of a patient with alcoholic cirrhosis decompensated by bleeding gastric varices treated with BRTO...
March 2016: Journal of Gastrointestinal and Liver Diseases: JGLD
https://www.readbyqxmd.com/read/26582597/when-should-we-propose-liver-transplant-after-resection-of-hepatocellular-carcinoma-a-comparison-of-salvage-and-de-principe-strategies
#10
COMPARATIVE STUDY
Ecoline Tribillon, Louise Barbier, Claire Goumard, Sabine Irtan, Fabiano Perdigao-Cotta, François Durand, Valérie Paradis, Jacques Belghiti, Olivier Scatton, Olivier Soubrane
INTRODUCTION: The aim of this study was to compare survival outcomes in patients enlisted for liver transplantation following liver resection for hepatocellular carcinoma before or at recurrence. METHODS: All patients enlisted for liver transplantation following liver resection for hepatocellular carcinoma from 1996 to 2013 were included and compared according to their status at the time of enlistment: before (de principe) or at (salvage) recurrence. Primary end-point was survival since resection...
January 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/26566246/antiviral-therapy-for-chronic-hepatitis-b-viral-infection-in-adults-a-systematic-review-and-meta-analysis
#11
REVIEW
Anna S F Lok, Brian J McMahon, Robert S Brown, John B Wong, Ahmed T Ahmed, Wigdan Farah, Jehad Almasri, Fares Alahdab, Khalid Benkhadra, Mohamed A Mouchli, Siddharth Singh, Essa A Mohamed, Abd Moain Abu Dabrh, Larry J Prokop, Zhen Wang, Mohammad Hassan Murad, Khaled Mohammed
UNLABELLED: Chronic hepatitis B viral (HBV) infection remains a significant global health problem. Evidence-based guidelines are needed to help providers determine when treatment should be initiated, which medication is most appropriate, and when treatment can safely be stopped. The American Association for the Study of Liver Diseases HBV guideline methodology and writing committees developed a protocol a priori for this systematic review. We searched multiple databases for randomized controlled trials and controlled observational studies that enrolled adults ≥18 years old diagnosed with chronic HBV infection who received antiviral therapy...
January 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/26546175/chronic-hepatitis-c-burden-of-disease-and-cost-associated-with-hospitalisations-in-france-in-2012-the-hepc-lone-study
#12
Armand Abergel, Michel Rotily, Sébastien Branchoux, Raoudha Akremi, Lucie de Léotoing, Alexandre Vainchtock, Anne-Françoise Gaudin
BACKGROUND AND OBJECTIVE: This retrospective hospital database analysis aimed to determine the burden and cost of hospitalisations related to chronic hepatitis C (CHC) infections in France in 2012. METHODS: All hospital stays with CHC (ICD-10 code B18.2) coded as the principal, related or significantly associated diagnosis were extracted from the French National Hospital database 2012 (PMSI). Hospitalisations not directly related to CHC were excluded. Patients were assigned to a liver disease stage, namely non-cirrhotic liver disease, compensated cirrhosis, decompensated cirrhosis, hepatocellular carcinoma or post-liver transplantation...
June 2016: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/26484707/statins-are-associated-with-a-decreased-risk-of-decompensation-and-death-in-veterans-with-hepatitis-c-related-compensated-cirrhosis
#13
Arpan Mohanty, Janet P Tate, Guadalupe Garcia-Tsao
BACKGROUND & AIMS: Statins decrease portal pressure in patients with cirrhosis and increase survival times of patients who have bled from varices. However, statins can be hepatotoxic. It is important to determine whether long-term statin use will be beneficial or detrimental for patients with cirrhosis because physicians are reluctant to prescribe statins to patients with liver disease. We investigated the effects of statins on decompensation and survival times in patients with compensated cirrhosis...
February 2016: Gastroenterology
https://www.readbyqxmd.com/read/26423777/patients-with-cirrhosis-in-the-ed-early-predictors-of-infection-and-mortality
#14
Rafael Oliveira Ximenes, Alberto Queiroz Farias, Augusto Scalabrini Neto, Márcio Augusto Diniz, Gabriel Taricani Kubota, Maurício Menezes Aben-Athar Ivo, Caroline Gracia Plena Sol Colacique, Luiz Augusto Carneiro D'Albuquerque, Roger Daglius Dias
BACKGROUND: Patients with cirrhosis have high risk of bacterial infections and cirrhosis decompensation, resulting in admission to emergency department (ED). However, there are no criteria developed in the ED to identify patients with cirrhosis with bacterial infection and with high mortality risk. STUDY OBJECTIVE: The objective of the study is to identify variables from ED arrival associated with bacterial infections and inhospital mortality. METHODS: This is a retrospective single-center study using a tertiary hospital's database to identify consecutive ED patients with decompensated cirrhosis...
January 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/26052398/role-of-antiviral-therapy-in-the-natural-history-of-hepatitis-b-virus-related-chronic-liver-disease
#15
REVIEW
Francesco Paolo Russo, Kryssia Rodríguez-Castro, Laura Scribano, Giorgia Gottardo, Veronica Vanin, Fabio Farinati
Hepatitis B virus (HBV) infection is a dynamic state of interactions among HBV, hepatocytes, and the host immune system. Natural history studies of chronic hepatitis B (CHB) infection have shown an association between active viral replication and adverse clinical outcomes such as cirrhosis and hepatocellular carcinoma. The goal of therapy for CHB is to improve quality of life and survival by preventing progression of the disease to cirrhosis, decompensation, end-stage liver disease, hepatocellular carcinoma (HCC) and death...
May 18, 2015: World Journal of Hepatology
https://www.readbyqxmd.com/read/25820757/salivary-microbiota-reflects-changes-in-gut-microbiota-in-cirrhosis-with-hepatic-encephalopathy
#16
Jasmohan S Bajaj, Naga S Betrapally, Phillip B Hylemon, Douglas M Heuman, Kalyani Daita, Melanie B White, Ariel Unser, Leroy R Thacker, Arun J Sanyal, Dae Joong Kang, Masoumeh Sikaroodi, Patrick M Gillevet
UNLABELLED: Altered gut microbiome is associated with systemic inflammation and cirrhosis decompensation. However, the correlation of the oral microbiome with inflammation in cirrhosis is unclear. Our aim was to evaluate the oral microbiome in cirrhosis and compare with stool microbiome. Outpatients with cirrhosis (with/without hepatic encephalopathy [HE]) and controls underwent stool/saliva microbiome analysis (for composition and function) and also systemic inflammatory evaluation. Ninety-day liver-related hospitalizations were recorded...
October 2015: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/25702055/-diagnosis-and-therapy-of-chronic-hepatitis-b-czech-national-guidelines
#17
Petr Husa, Jan Šperl, Petr Urbánek, Stanislav Plíšek, Petr Kümpel, Luděek RoŽnovský
The new recommendations reflect the increase in knowledge that has been reported since the release of previous Czech guidelines in April 2009. According to qualified estimates, there are 350-400 million people with chronic hepatitis B (HBV) infection worldwide. The Czech Republic is among the countries with a low prevalence of HBV infection. According to the latest seroprevalent study, 0.56 % of the Czech citizens were chronically infected with HBV in 2001. HBV infection can lead to serious life-threatening liver damage - fulminant hepatitis, liver cirrhosis and hepatocellular carcinoma (HCC)...
December 2014: Klinická Mikrobiologie a Infekc̆ní Lékar̆ství
https://www.readbyqxmd.com/read/25672930/cost-effectiveness-analysis-of-antiviral-therapies-for-hepatitis-b-e-antigen-positive-chronic-hepatitis-b-patients-in-china
#18
Chi Zhang, Weixia Ke, Yanhui Gao, Shudong Zhou, Li Liu, Xiaohua Ye, Zhenjiang Yao, Yi Yang
BACKGROUND AND OBJECTIVE: Several antiviral therapies are now available for patients with chronic hepatitis B (CHB), but the most cost-effective strategy for Chinese patients is unclear. The aim of this study was to estimate the long-term cost effectiveness of the antiviral treatments (lamivudine, adefovir, telbivudine and entecavir) for hepatitis B e antigen (HBeAg)-positive CHB patients in China. METHODS: A Markov model was used to simulate the life-time (41-year time span) costs and effectiveness associated with antiviral treatments from the perspective of Chinese healthcare...
March 2015: Clinical Drug Investigation
https://www.readbyqxmd.com/read/25594703/assessment-and-monitoring-of-liver-function-by-%C3%A2-%C3%A2-c-aminopyrine-breath-test-after-selective-transarterial-chemoembolisation-of-hepatocellular-carcinoma
#19
K Schütte, R Seidensticker, O Milbradt, J Bornschein, A Kandulski, M Pech, S Kropf, J Ricke, P Malfertheiner
BACKGROUND: Liver function and tumor staging are essential parameters for selection of treatment modalities in patients with hepatocellular carcinoma (HCC). Transarterial chemoembolization (TACE) is associated with a risk of deterioration of liver function. In clinical routine hepatic function in patients with liver cirrhosis is assessed by the Child-Pugh-classification. Dynamic breath tests allow the assessment of the hepatic functional mass and have the potential to give more accurate information on hepatic function periinterventionally...
January 2015: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/25511871/therapeutic-vaccines-in-treating-chronic-hepatitis-b-the-end-of-the-beginning-or-the-beginning-of-the-end
#20
REVIEW
Marie-Louise Michel, Maryline Bourgine, Hélène Fontaine, Stanislas Pol
The antiviral treatment of chronic hepatitis B virus (HBV) infection has greatly improved over the last 20 years since it has allowed a disappearance of cirrhosis decompensation and a significant reduction of the incidence of hepatocellular carcinoma. However, a complete HBV cure has not been achieved, and alternative treatments are still needed to optimize the current treatments. Therapeutic vaccination is a promising new strategy for controlling persistent infections and tumors. However, this approach has not been as successful as initially anticipated for chronic hepatitis B...
February 2015: Medical Microbiology and Immunology
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