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JOURNAL ARTICLE
Yun Yan, Karunaratne Tennekoon, Audrey Eubanks, Anam Herekar, Dhanush Shimoga, Deepak Ayyala, Colin McLeod, Julie A Kurek, John C Morgan, Satish S C Rao, Amol Sharma
BACKGROUND: Parkinson's disease (PD) is a neurodegenerative movement disorder with prodromal and highly prevalent gastrointestinal (GI) symptoms, especially constipation. Although PD models suggest gut-brain axis dysfunction, the mechanistic underpinnings and their correlation with GI symptoms are poorly understood. AIM: To examine the bidirectional gut-brain axis function in PD and correlate it with constipation severity, PD duration, and severity. METHODS: Rectal sensory thresholds and afferent cortical evoked potentials (CEP) were assessed using a 4-ring EMG electrode probe...
December 17, 2023: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
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JOURNAL ARTICLE
Valliappan Muthu, Ritesh Agarwal, Shivaprakash Mandya Rudramurthy, Deepak Thangaraju, Manoj Radhakishan Shevkani, Atul K Patel, Prakash Srinivas Shastri, Ashwini Tayade, Sudhir Bhandari, Vishwanath Gella, Jayanthi Savio, Surabhi Madan, Vinaykumar Hallur, Venkata Nagarjuna Maturu, Arjun Srinivasan, Nandini Sethuraman, Raminder Pal Singh Sibia, Sanjay Pujari, Ravindra Mehta, Tanu Singhal, Puneet Saxena, Varsha Gupta, Vasant Nagvekar, Parikshit Prayag, Dharmesh Patel, Immaculata Xess, Pratik Savaj, Inderpaul Singh Sehgal, Naresh Panda, Gayathri Devi Rajagopal, Riya Sandeep Parwani, Kamlesh Patel, Anuradha Deshmukh, Aruna Vyas, Raghava Rao Gandra, Srinivas Kishore Sistla, Priyadarshini A Padaki, Dharshni Ramar, Saurav Sarkar, Bharani Rachagulla, Pattabhiraman Vallandaramam, Krishna Prabha Premachandran, Sunil Pawar, Piyush Gugale, Pradeep Hosamani, Sunil Narayan Dutt, Satish Nair, Hariprasad Kalpakkam, Sanjiv Badhwar, Kiran Kumar Kompella, Nidhi Singla, Milind Navlakhe, Amrita Prayag, Gagandeep Singh, Poorvesh Dhakecha, Arunaloke Chakrabarti
OBJECTIVES: To compare COVID-19-associated pulmonary mucormycosis (CAPM) with COVID-19-associated rhino-orbital mucormycosis (CAROM), ascertain factors associated with CAPM among patients with COVID-19, and identify factors associated with 12-week mortality in CAPM. METHODS: We performed a retrospective multicenter cohort study. All study participants had COVID-19. We enrolled CAPM, CAROM, and COVID-19 subjects without mucormycosis (controls; age-matched). We collected information on demography, predisposing factors, and details of COVID-19 illness...
December 9, 2023: Clinical Microbiology and Infection
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JOURNAL ARTICLE
Rekha Koravadi Narasimhamurthy, Babu Santhi Venkidesh, Sangeetha Nayak, Dinesh Reghunathan, Sandeep Mallya, Krishna Sharan, Bola Sadashiva Satish Rao, Kamalesh Dattaram Mumbrekar
Neurodegenerative disorders are a debilitating and persistent threat to the global elderly population, carrying grim outcomes. Their genesis is often multifactorial, with a history of prior exposure to xenobiotics such as pesticides, heavy metals, enviornmental pollutants, ionizing radiation etc,. A holistic molecular insight into their mechanistic induction upon single or combinatorial exposure to different toxicants is still unclear. In the present study, one-month-old C57BL/6 male mice were administered orally with malathion (50 mg/kg body wt...
December 1, 2023: Environmental Science and Pollution Research International
#24
JOURNAL ARTICLE
Alimu Dayimu, Avinash Gupta, Rubeta N Matin, Jenny Nobes, Ruth Board, Miranda Payne, Ankit Rao, Alberto Fusi, Sarah Danson, Bryony Eccles, Judith Carser, Ciara O'Hanlon Brown, Neil Steven, Madhumita Bhattacharyya, Ewan Brown, Michael Gonzalez, Martin Highley, Lisa Pickering, Satish Kumar, Ashita Waterston, George Burghel, Leigh Demain, Eleanor Baker, Jerome Wulff, Wendi Qian, Sophie Twelves, Mark Middleton, Pippa Corrie
BACKGROUND: BRAF+MEK inhibitors extend life expectancy of patients with BRAFV600 mutant advanced melanoma. Acquired resistance limits duration of benefit, but preclinical and case studies suggest intermittent dosing could overcome this limitation. INTERIM was a phase 2 trial evaluating an intermittent dosing regimen. METHODS: Patients with BRAFV600 mutant advanced melanoma due to start dabrafenib+trametinib were randomised to receive either continuous (CONT), or intermittent (INT; dabrafenib d1-21, trametinib d1-14 every 28 days) dosing...
November 24, 2023: European Journal of Cancer
#25
JOURNAL ARTICLE
Amit Hudgi, Yun Yan, Deepak Ayyala, Satish S C Rao
INTRODUCTION: Fecal incontinence (FI) is characterized by both irregular and unpredictable bowel symptoms. An accurate history of symptoms is important for diagnosis and guiding management. Whether a patient's history of bowel symptoms is reliable or if there is recall bias is unknown. AIM: To evaluate the accuracy of FI symptoms based on patient's recall compared with a prospective stool diary. METHODS: FI (Rome IV) patients completed a bowel questionnaire that included leakage episodes and stool consistency...
November 23, 2023: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
#26
Shalesh Rohatgi, Satish Nirhale, Prajwal Rao, Pravin Naphade, Furqan Khan
Neurolymphomatosis (NL) is a rare clinical disease where neoplastic cells invade the cranial nerves, roots, plexus, or other peripheral nerves in patients with hematologic malignancy mainly Non-Hodgkins Lymphoma(NHL). Primary NL occurs as the first manifestation of a hematologic malignancy. We report a 68-year male who presented to us with low backache and burning paraesthesia in the back of both lower limbs followed by a left foot drop. The clinical and electrophysiological examination was suggestive of bilateral lumbosacral radiculopathy involving L2-S1 roots...
2023: Neurology India
#27
REVIEW
Chandrakanth Are, Shilpa S Murthy, Richard Sullivan, Makayla Schissel, Sanjib Chowdhury, Olesegun Alatise, Daniel Anaya, Madhuri Are, Charles Balch, David Bartlett, Murray Brennan, Lydia Cairncross, Matthew Clark, S V S Deo, Vikas Dudeja, Domenico D'Ugo, Ibtihal Fadhil, Armando Giuliano, Satish Gopal, Lily Gutnik, Andre Ilbawi, Pankaj Jani, Peter Kingham, Laura Lorenzon, Premila Leiphrakpam, Augusto Leon, Hector Martinez-Said, Kelly McMasters, David O Meltzer, Miriam Mutebi, Zafar Nabeel, Vibhavari Naik, Lisa Newman, Alexandre Ferreira Oliveira, Do Joong Park, C S Pramesh, Saieesh Rao, T Subramanyeshwar Rao, Enrique Rocha Bargallo, Anya Romanoff, Anne F Rositch, Isabel Rubio, Heber Salvador de Castro Ribeiro, Eman Sbaity, Maheswari Senthil, Lynette Smith, Masakazi Toi, Kiran Turaga, Ujwal Yanala, Cheng-Har Yip, Ashraf Zaghloul, Benjamin O Anderson
The first Lancet Oncology Commission on Global Cancer Surgery was published in 2015 and serves as a landmark paper in the field of cancer surgery. The Commission highlighted the burden of cancer and the importance of cancer surgery, while documenting the many inadequacies in the ability to deliver safe, timely, and affordable cancer surgical care. This Commission builds on the first Commission by focusing on solutions and actions to improve access to cancer surgery globally, developed by drawing upon the expertise from cancer surgery leaders across the world...
November 1, 2023: Lancet Oncology
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JOURNAL ARTICLE
William L Hasler, Allen A Lee, Baharak Moshiree, Brian C Surjanhata, Satish Rao, Henry P Parkman, Linda A Nguyen, Irene Sarosiek, John M Wo, Michael I Schulman, Richard W McCallum, Braden Kuo
BACKGROUND & AIMS: Prokinetics have limited effectiveness for treating symptoms of gastroparesis. Thus, alternative or adjunct therapies, such as gastroparesis diets or neuromodulators, are often prescribed. Their therapeutic benefits alone or in combination remain unclear. METHODS: One hundred and twenty-nine patients with symptoms of gastroparesis underwent wireless motility capsule gastric emptying time and gastric emptying scintigraphy. Based on test results, changes in therapy were recommended...
October 30, 2023: Clinical Gastroenterology and Hepatology
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JOURNAL ARTICLE
Ripu Daman Arora, Karthik Nagaraja Rao, Satish Satpute, Rupa Mehta, Prajwal Dange, Nitin M Nagarkar, A P Abishek
Over 30% of cases may present with acute airway obstruction due to anaplastic thyroid cancer (ATC). In such situations, performing an emergency tracheostomy may be mandatory to save the life. A retrospective, single-centre study at our centre was conducted between 1 January 2021 to 31 December 2022. We had included 17 patients with asphyxia due to ATC and subsequently underwent tracheostomy for stridor. The overall survival (OS) ranged from 2 days to 16 months (median = 11 months)...
September 2023: Indian Journal of Surgical Oncology
#30
JOURNAL ARTICLE
Satish G Patil, Vitthal Khode, Edmin Christa, Rathnamala M Desai, Ambalam M Chandrasekaran, Hosakote S Vadiraja, Rao Raghavendra, Kiran Aithal, R Champa, Kishore Kumar Deepak, Ambuj Roy, Sanjay Kinra, Prabhakaran Dorairaj
Introduction: Endothelial dysfunction is the initial step in the pathogenesis of atherosclerosis; and it plays a central role in the development of cardiovascular diseases and many types of human diseases (diabetes, kidney failure, cancer, and viral infections). Strategies that are effective in protecting vascular endothelial function and retard or reversing endothelial dysfunction in the early stage appear to be potential in the prevention of vascular, cardiac, and many human diseases. Several studies have been carried out on the effects of yoga on endothelial function, but the results of these studies have not been synthesized...
October 25, 2023: J Integr Complement Med
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JOURNAL ARTICLE
Chitra Subramanian, Matthew W Frank, Rajaa Sukun, Christopher E Henry, Anna Wade, Mallory E Harden, Satish Rao, Rajendra Tangallapally, Mi-Kyung Yun, Stephen W White, Richard E Lee, Uma Sinha, Charles O Rock, Suzanne Jackowski
Pantothenate kinase associated neurodegeneration (PKAN) is characterized by a motor disorder with combinations of dystonia, parkinsonism and spasticity, leading to premature death. PKAN is caused by mutations in the PANK2 gene that result in loss or reduction of PANK2 protein function. PANK2 is one of three kinases that initiate and regulate coenzyme A biosynthesis from vitamin B5 and the ability of BBP-671, an allosteric activator of pantothenate kinases, to enter the brain and elevate coenzyme A was investigated...
October 24, 2023: Journal of Pharmacology and Experimental Therapeutics
#32
JOURNAL ARTICLE
Pravin Naphade, Pratistha Singh, Prajwal Rao, Shalesh Rohatgi, Suprakash Chaudhury, Sudhir Jadhav, Satish Nirhale
INTRODUCTION: Psychiatric symptoms and fatigue are common after the coronavirus disease 2019 (COVID-19) illness. The cause of these symptoms is direct neuronal injury and indirect injury with immune-mediated inflammation. In addition, social factors also affect mental health. OBJECTIVE: We aim to compare psychiatric symptoms and fatigue between COVID-19 survivors and healthy controls. MATERIAL AND METHODS: We prospectively evaluated 100 COVID-19 survivors for anxiety, depression, positive affect, and behavior control using the Mental Health Inventory (MHI)...
September 2023: Curēus
#33
Satish Nirhale, Shalesh Rohatgi, Prajwal Rao, Pravin Naphade, Khushboo S Hatekar
Cerebral venous sinus thrombosis (CVST) usually presents with headaches, seizures, and signs and symptoms of raised intracranial pressure (ICP). Risk factors for CVST commonly include hypercoagulable states such as pregnancy and the peripartum period, dehydration, vitamin B12 deficiency, hyper-homocysteinemia, coagulation factor deficiency, antiphospholipid antibody disease, oral contraceptive pill intake, etc. CVST with venous hemorrhagic infarction is commonly reported, but only a few cases have been reported in the literature of CVST presenting as SDH...
September 2023: Curēus
#34
JOURNAL ARTICLE
Nikhil Sathe, Sameer Shaikh, Mahesh Bhavsar, Leena Parte, Anjaneyulu Gadiparthi, Satish Kad, Sayandev Sensarma, Hassan Nalband, R Sangapillai, S Sivashanmuganathan, Rakhi Pusalkar, Sathyavathy Anandan, Girish Masand, K Pratapreddy, S Harinarayana Rao, Abhiram Gokhale, G E C Vidyadhar Reddy, Gopala Karanam, Abhishek Phatarphekar, Praveen Rao, Venkata Ramana, R L Ramnath
SARS-CoV-2, severe acute respiratory syndrome coronavirus-2, causes coronavirus disease- 2019 (COVID-19). Mostly, COVID-19 causes respiratory symptoms that can resemble those of a cold, the flu, or pneumonia. COVID-19 may harm more than just lungs and respiratory systems. It may also have an impact on other parts of the body and debilitating effects on humans, necessitating the development of vaccines at an unprecedented rate in order to protect humans from infections. In response to SARS-CoV-2 infection, mRNA, viral vector-based carrier and inactivated virus-based vaccines, as well as subunit vaccines, have recently been developed...
October 8, 2023: Vaccine
#35
JOURNAL ARTICLE
Satish Kumar Mummidivarapu, Shaik Rehana, Y R Satyaji Rao
Water quality modelling has proved to be effective method for managing river water quality. But the most effective and comprehensive approach involving integration of river water quality simulation and pollution visualization with the objective of pollution reduction and maintenance of environmental flow strategies has gained less attention. Thus, the objective of this study was to employ an integrated approach for mapping and analysing river water quality under various hydro-climatic and pollution scenarios...
October 3, 2023: Environmental Research
#36
Himanshu R Prasad, P V Satyanarayana Murthy, D Anjaneyulu Reddy, Himakanth Lingala, Satish Rao Immaneni, A V Gurava Reddy
INTRODUCTION: Aneurysmal bone cyst (ABC) of cervical spine is rare in the pediatric age groups. It brings along a gamut of problems in management such as growth disturbances, instability, deformities, and neurological deficiencies. We report a case that was successfully managed by intralesional injection, making it safe and reproducible. CASE REPORT: A 12-year-old girl presented with pain and swelling around the nape of neck that increased in size over 1 year. Imaging and biopsy were suggestive of ABC...
September 2023: Journal of Orthopaedic Case Reports
#37
JOURNAL ARTICLE
S Shruthi, Kamalesh D Mumbrekar, B S Satish Rao, Bhasker K Shenoy
Gallic acid (GA) is a natural polyhydroxyphenolic compound with antioxidant, antimutagenic, anti-inflammatory, and antineoplastic activities. Cisplatin (CPT) is a platinum-based chemotherapeutic drug, and it is the treatment of choice for breast, ovarian, testicular, head, and neck cancers. However, the use of anticancer drugs has undesirable effects on patients due to associated toxicities. Thus, it is necessary to search for alternatives that reduce unintended side effects and enhance anticancer potential...
August 2023: Toxicology Research
#38
JOURNAL ARTICLE
Benumadhab Ghosh, Isha Sahai, Gajendra Agrawal, Satish Khadase, Tarun Rao, Akash Lohakare, Anuj Chaturvedi, Shantanu Gomase
Background Ventricular septal defects (VSDs) are the most common type of septal defects in early infants and are very complicated. This has paved the way for the development of new minimally invasive procedures for interventional cardiologists. This study presents our experience using duct occluders instead of conventional ventricular septal devices in the Department of Cardiology at Acharya Vinoba Bhave Rural Hospital (AVBRH) in central rural India. This study aimed to review success and complications and assess safety and its relation to age, sex, size of the VSDs, type of VSD, and types of devices used after transcatheter closure of perimembranous and muscular VSDs using various types of duct occluders...
July 2023: Curēus
#39
JOURNAL ARTICLE
Shalesh Rohatgi, Prajwal Rao, Satish Nirhale, Pravin Naphade, Prashant Dubey
No abstract text is available yet for this article.
2023: Annals of Indian Academy of Neurology
#40
JOURNAL ARTICLE
Prajwal Rao, Varsha Rangankar, Shalesh Rohatgi, Prashant Dubey, Advait Gitay, Anmol Singh, S L Jadhav, Satish Nirhale, Pravin Naphade
BACKGROUND: Identifying early predictors of severe Covid-19 associated mucormycosis (CAM) can help improve management and treatment outcomes. OBJECTIVES: Primary: To identify clinical and radiological predictors of disease severity in CAM. Secondary: To describe patterns of central nervous system (CNS) involvement in CAM. METHODS: A total of 71 patients with CAM were included in the study. Based on the anatomical extent of involvement on MRI, patients were divided into three groups: Sinus (paranasal sinuses), Orbit (orbital spread), and CNS (CNS spread)...
November 2023: Infectious Diseases
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