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Satish Rao

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https://www.readbyqxmd.com/read/29140124/apprenticeship-based-training-in-neurogastroenterology-and-motility
#1
Dipesh H Vasant, Amol Sharma, Jigar Bhagatwala, Lavanya Viswanathan, Satish S C Rao
Although neurogastroenterology and motility (NGM) disorders affect 50% of patients seen in clinics, many gastroenterologists receive limited NGM training. One-month apprenticeship-based NGM training has been provided at ten centers in the USA for a decade, however, outcomes of this training are unclear. Our goal was to describe the effectiveness of this program from a trainees perspective. Areas Covered: We describe the training model, learning experiences, and outcomes of one-month apprenticeship-based training in NGM at a center of excellence, using a detailed individual observer account and data from 12 consecutive trainees that completed the program...
November 15, 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29111136/factors-associated-with-response-to-biofeedback-therapy-for-dyssynergic-defecation
#2
Tanisa Patcharatrakul, Jessica Valestin, Amanda Schmeltz, Konrad Schulze, Satish S C Rao
BACKGROUND & AIMS: Biofeedback therapy (BT) is effective for dyssynergic defecation (DD), but it is not widely available or reimbursed, and is labor intensive. It is therefore important to select the appropriate patients for this treatment. We investigated symptoms and demographic, manometric, and other factors associated with outcomes of BT in patients with DD. METHODS: We performed a post-hoc analysis of 2 prospective studies of BT in 127 adult outpatients (18-75 years old, 120 female) with chronic constipation who failed to respond to treatment with dietary fiber or laxatives (>1 year) and were diagnosed with DD based on standard criteria...
October 27, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29101709/laser-induced-autofluorescence-based-objective-evaluation-of-burn-tissue-repair-in-mice
#3
Bharath Rathnakar, Bola Sadashiva Satish Rao, Vijendra Prabhu, Subhash Chandra, Krishna Kishore Mahato
Management of burn injuries are a growing concern, especially in determining the progression of healing. Several techniques are being practiced in clinics and have been considered all-time standard approaches to determine pre- and post-treatment outcomes of a healthy healing. However, these kinds of methods involve repeated biopsies and thereby hindering tissue repair. In view of this, our perspective was to develop a non-invasive tool in an attempt to provide a solution to determine the progression of healing, in vivo...
November 3, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/29050194/update-on-the-pathophysiology-and-management-of-anorectal-disorders
#4
REVIEW
Tanisa Patcharatrakul, Satish S C Rao
Anorectal disorders are common and present with overlapping symptoms. They include several disorders with both structural and functional dysfunction(s). Because symptoms alone are poor predictors of the underlying pathophysiology, a diagnosis should only be made after evaluating symptoms and physiologic and structural abnormalities. A detailed history, a thorough physical and digital rectal examination and a systematic evaluation with high resolution and/or high definition three-dimensional (3D) anorectal manometry, 3D anal ultrasonography, magnetic resonance defecography and neurophysiology tests are essential to correctly identify these conditions...
October 23, 2017: Gut and Liver
https://www.readbyqxmd.com/read/28982955/mutation-spectrum-of-ndp-fzd4-and-tspan12-genes-in-indian-patients-with-retinopathy-of-prematurity
#5
Sonika Rathi, Subhadra Jalali, Ganeswara Rao Musada, Satish Patnaik, Divya Balakrishnan, Anjli Hussain, Inderjeet Kaur
AIM: Retinopathy of prematurity (ROP) is a vasoproliferative eye disease in preterm infants. Based on its phenotypic similarities with familial exudative vitreo retinopathy (FEVR), the present study was conducted to screen the Norrin signalling pathway genes (already been implicated in FEVR) for understanding their involvement among Indian patients with ROP. METHODS: The study cohort consisted of patients with ROP (n=246) and controls (n=300) that included full term (n=110) and preterm babies devoid of ROP (n=190)...
October 5, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28948467/post-infectious-irritable-bowel-syndrome
#6
REVIEW
Yeong Yeh Lee, Chandramouli Annamalai, Satish S C Rao
PURPOSE OF REVIEW: Post-infectious irritable bowel syndrome (PI-IBS) is characterized by persistent abdominal pain and diarrhea, typically following an episode of infectious gastroenteritis. The mechanisms that underlie IBS-D remain elusive, but PI-IBS provides a mechanistic model of this disorder. This review provides an up-to-date appraisal of the pathophysiology, clinical features, and management approaches for PI-IBS. RECENT FINDINGS: Disordered immune reactions and release of cytokines with resultant gut inflammation and dysfunction appear to be key features of PI-IBS...
September 25, 2017: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/28932270/repeat-treatment-with-rifaximin-improves-irritable-bowel-syndrome-related-quality-of-life-a-secondary-analysis-of-a-randomized-double-blind-placebo-controlled-trial
#7
Brooks D Cash, Mark Pimentel, Satish S C Rao, Leonard Weinstock, Lin Chang, Zeev Heimanson, Anthony Lembo
BACKGROUND: Diarrhea-predominant irritable bowel syndrome (IBS-D) impairs patient quality of life (QOL). Rifaximin is an oral, nonsystemic antibiotic indicated for IBS-D. The objective of this secondary analysis was to evaluate rifaximin retreatment on IBS-related QOL in patients with IBS-D. METHODS: Patients received open-label rifaximin 550 mg three times daily for 2 weeks. Clinical responders [simultaneously meeting weekly response criteria for abdominal pain (⩾30% improvement from baseline in mean weekly pain score) and stool consistency (⩾50% decrease from baseline in number of days/week with Bristol Stool Scale (BSS) type 6 or 7 stools) during ⩾2 of first 4 weeks posttreatment] who relapsed during an up to 18-week treatment-free observation phase were randomly assigned to receive two 2-week courses of double-blind rifaximin or placebo, separated by 10 weeks...
September 2017: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/28873373/biomarkers-of-renal-injury-in-cirrhosis-association-with-acute-kidney-injury-and-recovery-after-liver-transplantation
#8
Ashwani K Singal, Bradford Jackson, Glauber B Pereira, Kirk B Russ, Paul Stephen Fitzmorris, Donny Kakati, Page Axley, Sujan Ravi, Toni Seay, Satish P Ramachandra Rao, Ravindra Mehta, Yong-Fang Kuo, Karan P Singh, Anupam Agarwal
BACKGROUND: To define urine or serum biomarkers in predicting renal function recovery after liver transplantation (LT). METHODS: Adults listed for LT (February 2011-July 2014) and with modified diet for renal disease-6 (MDRD-6) <60 mL/min provided urine/blood samples at baseline and serially until LT for biomarkers in serum (pg/mL) and urine (pg/mg creatinine). RESULTS: Of 271 LT listed patients (mean age 57 years, 63% males, median listing MELD 17...
September 2, 2017: Nephron
https://www.readbyqxmd.com/read/28838787/surgical-interventions-and-the-use-of-device-aided-therapy-for-the-treatment-of-fecal-incontinence-and-defecatory-disorders
#9
Adil E Bharucha, Satish S C Rao, Andrea S Shin
The purpose of this clinical practice update expert review is to describe the key principles in the use of surgical interventions and device-aided therapy for managing fecal incontinence (FI) and defecatory disorders. The best practices outlined in this review are based on relevant publications, including systematic reviews and expert opinion (when applicable). Best Practice Advice 1: A stepwise approach should be followed for management of FI. Conservative therapies (diet, fluids, techniques to improve evacuation, a bowel training program, management of diarrhea and constipation with diet and medications if necessary) will benefit approximately 25% of patients and should be tried first...
December 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28794916/clinical-variability-in-familial-x-linked-ohdo-syndrome-maat-kievit-brunner-type-with-med12-mutation
#10
Siddaramappa J Patil, Puneeth H Somashekar, Anju Shukla, Satish Siddaiah, Venkatraman Bhat, Katta M Girisha, Pooja N Rao
Ohdo syndrome-Maat-Kievit-Brunner (OSMKB) type is an X-linked recessive disorder, a subtype of blepharophimosis-intellectual disability syndromes caused by mutations in the mediator complex subunit 12 ( MED12 ) gene. Here we report a familial OSMKB type with two affected siblings and mutation in MED12 gene.
September 2017: Journal of Pediatric Genetics
https://www.readbyqxmd.com/read/28750217/association-of-hsd11b1-gene-polymorphisms-with-type-2-diabetes-and-metabolic-syndrome-in-south-indian-population
#11
Nayana Devang, Kapaettu Satyamoorthy, Padmalatha S Rai, M Nandini, Satish Rao, Nagaraja M Phani, Prabha Adhikari
BACKGROUND: 11beta-hydroxysteroid dehydrogenase Type 1 (11β-HSD1) is an NADP or NADPH-dependent enzyme that generates cortisol from cortisone for a local glucocorticoid action. Functional polymorphisms within 11beta-hydroxysteroid dehydrogenase Type 1 (HSD11B1) gene have shown an association with various factors, including insulin resistance (IR) and hypertension. In our study, we have assessed the association of HSD11B1 (rs12086634 and rs846910) gene polymorphisms with type 2 diabetes (T2D) and metabolic syndrome (metS)...
July 13, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28731079/a-polymeric-temozolomide-nanocomposite-against-orthotopic-glioblastoma-xenograft-tumor-specific-homing-directed-by-nestin
#12
Suma Prabhu, Jayant Sastri Goda, Srinivas Mutalik, Bhabani Shankar Mohanty, Pradip Chaudhari, Sharada Rai, Nayanabhirama Udupa, Bola Sadashiva Satish Rao
The development of effective therapeutic strategies for glioblastoma faces challenges such as modulating the blood brain barrier (BBB) for drug influx and selectively targeting tumor cells. Nanocarrier drug delivery strategies are functionalized to enhance vascular permeability. We engineered superparamagnetic iron oxide nanoparticle (SPION) based polymeric nanocomposites (84.37 ± 12.37 nm / 101.56 ± 7.42 nm) embedding temozolomide (TMZ) targeted against glioblastoma by tagging an antibody against nestin, a stem cell marker, and transferrin / polysorbate-80 to permeate the BBB...
August 3, 2017: Nanoscale
https://www.readbyqxmd.com/read/28713755/tumor-induced-osteomalacia-a-sherlock-holmes-approach-to-diagnosis-and-management
#13
G V Chanukya, Manoj Mengade, Jagadishwar Goud, I Satish Rao, Anuj Jain
Tumor-induced osteomalacia (TIO) is a subtype of paraneoplastic syndrome associated with hypophosphatemia due to renal phosphate wasting in adults. The humoral factor responsible for clinical picture known as fibroblast growth factor 23 (FGF23) is most often secreted by benign yet elusive mesenchymal tumors, difficult to localize, access, and excise completely; rarely, they are multiple and malignant. Paradoxical inappropriately normal or low levels of 1,25-dihydroxyvitamin D in the setting of hypophosphatemia is due to suppressive effect of FGF23...
January 2017: Annals of Maxillofacial Surgery
https://www.readbyqxmd.com/read/28566850/antiplaque-efficacy-of-tooth-and-gums-tonic-hiora-ga-gel-and-spirogyl-gum-paint-in-comparison-with-chlorhexidine-m-gel-a-double-blind-randomized-control-trial
#14
Jagadeeswara Rao Sukhabogi, B R Chandra Shekar, I Venkata Ramana, Sarjeev Singh Yadav, G Satish Kumar, N Harita
OBJECTIVE: To compare the efficacy of three different herbal products (Tooth and Gums Tonic, Hiora-GA gel, and Spirogyl Gum paint) in reducing plaque, gingival inflammation and bacterial count in comparison with chlorhexidine M gel among participants with moderate to severe periodontitis. MATERIALS AND METHODS: A total of eighty participants with moderate to severe periodontitis were initially recruited after obtaining their informed consent. All participants were offered scaling and polishing on the first visit to remove visible calculus...
January 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/28555517/in-patient-mortality-among-plhiv-a-7-year-hospital-based-retrospective-study-in-coastal-south-india
#15
Omer Farhan, Basavaprabhu Achappa, Unnikrishnan Bhaskaran, Ramesh Holla, John T Ramapuram, Satish Rao, Deepak R Madi
BACKGROUND: With the wide usage of highly active antiretroviral therapy, the morbidity and mortality due to HIV have declined gradually. The aim of our study was to determine the cause of mortality among HIV-infected patients and the factors causing early death. METHODS: Using medical records of 73 inpatients who are dead, data were collected and analyzed using SPSS version 19 (IBM SPSS Statistics). Chi-square test was performed to determine the factors contributing to early death...
January 1, 2017: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/28479014/a-cystic-splenic-mass-in-a-farmer
#16
Satish B Rao, Deepak R Madi, Avinash K Shetty
No abstract text is available yet for this article.
May 3, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28448580/sildenafil-normalizes-bowel-transit-in-preclinical-models-of-constipation
#17
Sarah K Sharman, Bianca N Islam, Yali Hou, Margaux Usry, Allison Bridges, Nagendra Singh, Subbaramiah Sridhar, Satish Rao, Darren D Browning
Guanylyl cyclase-C (GC-C) agonists increase cGMP levels in the intestinal epithelium to promote secretion. This process underlies the utility of exogenous GC-C agonists such as linaclotide for the treatment of chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C). Because GC-C agonists have limited use in pediatric patients, there is a need for alternative cGMP-elevating agents that are effective in the intestine. The present study aimed to determine whether the PDE-5 inhibitor sildenafil has similar effects as linaclotide on preclinical models of constipation...
2017: PloS One
https://www.readbyqxmd.com/read/28422390/naringin-abates-adverse-effects-of-cadmium-mediated-hepatotoxicity-an-experimental-study-using-hepg2-cells
#18
Visesh Kumar Rathi, Shubhankar Das, Archana Parampalli Raghavendra, Bola Sadashiva Satish Rao
This study investigated the protective potential of Naringin (NIN) against cadmium chloride (CdCl2 ) mediated hepatotoxicity using human hepatocellular carcinoma (HepG2) cells. An optimal concentration of NIN (5 μM) was potent enough to confer cytoprotection against CdCl2 (50 μM) as was observed by MTT assay. Preconditioning with NIN maintained redox homeostasis, mitochondrial membrane potential, and reduced apoptosis as marked by decrease in the percentage sub-G0 /G1 and Annexin V-FITC/propidium iodide positive cells (apoptotic)...
August 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/28367561/cancerous-perturbations-within-the-erk-pi3k-akt-and-wnt-%C3%AE-catenin-signaling-network-constitutively-activate-inter-pathway-positive-feedback-loops
#19
Rahul Rao Padala, Rishabh Karnawat, Satish Bharathwaj Viswanathan, Abhishek Vijay Thakkar, Asim Bikas Das
Perturbations in molecular signaling pathways are a result of genetic or epigenetic alterations, which may lead to malignant transformation of cells. Despite cellular robustness, specific genetic or epigenetic changes of any gene can trigger a cascade of failures, which result in the malfunctioning of cell signaling pathways and lead to cancer phenotypes. The extent of cellular robustness has a link with the architecture of the network such as feedback and feedforward loops. Perturbation in components within feedback loops causes a transition from a regulated to a persistently activated state and results in uncontrolled cell growth...
May 2, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28323273/hydrogen-and-methane-based-breath-testing-in-gastrointestinal-disorders-the-north-american-consensus
#20
Ali Rezaie, Michelle Buresi, Anthony Lembo, Henry Lin, Richard McCallum, Satish Rao, Max Schmulson, Miguel Valdovinos, Salam Zakko, Mark Pimentel
OBJECTIVES: Breath tests (BTs) are important for the diagnosis of carbohydrate maldigestion syndromes and small intestinal bacterial overgrowth (SIBO). However, standardization is lacking regarding indications for testing, test methodology and interpretation of results. A consensus meeting of experts was convened to develop guidelines for clinicians and research. METHODS: Pre-meeting survey questions encompassing five domains; indications, preparation, performance, interpretation of results, and knowledge gaps, were sent to 17 clinician-scientists, and 10 attended a live meeting...
May 2017: American Journal of Gastroenterology
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