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Satish Rao

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https://www.readbyqxmd.com/read/29763303/design-and-synthesis-of-highly-potent-hiv-1-protease-inhibitors-containing-tricyclic-fused-ring-systems-as-novel-p2-ligands-structure-activity-studies-biological-and-x-ray-structural-analysis
#1
Arun K Ghosh, Prasanth R Nyalapatla, Satish Kovela, Kalapala Venkateswara Rao, Margherita Brindisi, Heather L Osswald, Masayuki Amano, Manabu Aoki, Johnson Agniswamy, Yuan-Fang Wang, Irene T Weber, Hiroaki Mitsuya
The design, synthesis, and biological evaluation of a new class of HIV-1 protease inhibitors containing stereochemically defined fused tricyclic polyethers as the P2 ligands and a variety of sulfonamide derivatives as the P2' ligands are described. A number of ring sizes and various substituent effects were investigated to enhance the ligand-backbone interactions in the protease active site. Inhibitors 5c and 5d containing this unprecedented fused 6-5-5 ring system as the P2 ligand, an aminobenzothiazole as the P2' ligand, and a difluorophenylmethyl as the P1 ligand exhibited exceptional enzyme inhibitory potency and maintained excellent antiviral activity against a panel of highly multidrug-resistant HIV-1 variants...
May 15, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29691369/does-colectomy-predispose-to-small-intestinal-bacterial-sibo-and-fungal-overgrowth-sifo
#2
Satish S C Rao, George Tan, Hamza Abdulla, Siegfried Yu, Sebastian Larion, Pornchai Leelasinjaroen
OBJECTIVES: After subtotal colectomy, 40% of patients report chronic gastrointestinal symptoms and poor quality of life. Its etiology is unknown. We determined whether small intestinal bacterial overgrowth (SIBO) or small intestinal fungal overgrowth (SIFO) cause gastrointestinal symptoms after colectomy. METHODS: Consecutive patients with unexplained abdominal pain, gas, bloating and diarrhea (>1 year), and without colectomy (controls), and with colectomy were evaluated with symptom questionnaires, glucose breath test (GBT) and/or duodenal aspiration/culture...
April 25, 2018: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/29689468/uplc-ms-ms-quantitative-analysis-and-structural-fragmentation-study-of-five-parmotrema-lichens-from-the-eastern-ghats
#3
K Kumar, Bandi Siva, V U M Sarma, Satish Mohabe, A Madhusudana Reddy, Joel Boustie, Ashok K Tiwari, N Rama Rao, K Suresh Babu
Comparative phytochemical analysis of five lichen species [Parmotrema tinctorum (Delise ex Nyl.) Hale, P. andinum (Mull. Arg.) Hale, P. praesorediosum (Nyl.) Hale, P. grayanum (Hue) Hale, P. austrosinense (Zahlbr.) Hale] of Parmotrema genus were performed using two complementary UPLC-MS systems. The first system consists of high resolution UPLC-QToF-MS/MS spectrometer and the second system consisted of UPLC-MS/MS in Multiple Reaction Monitoring (MRM) mode for quantitative analysis of major constituents in the selected lichen species...
April 19, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29675982/probing-endogenous-collagen-by-laser-induced-autofluorescence-in-burn-wound-biopsies-a-pilot-study
#4
Vijendra Prabhu, Anusha Acharya, Bola Sadashiva Satish Rao, Bharath Rathnakar, Pramod Kumar, Vasudeva Guddattu, Krishna Kishore Mahato
The focus of the current study was to interrogate the predictive potential of laser-induced autofluorescence (LIAF) by objectively assessing collagen synthesis in burn wound granulation tissues ex vivo. Prior grafting, granulation tissues (20 samples) following burn injury were collected from 17 subjects of age range 18- 60 years with patient/donor consent and the corresponding autofluorescence spectra were recorded at 325 nm He-Cd laser (≈ 2 mW) excitations. The resulting endogenous collagen intensity from the above tissue samples was computed by normalizing the NADH levels...
April 19, 2018: Journal of Biophotonics
https://www.readbyqxmd.com/read/29594642/room-temperature-lpg-resistive-sensor-based-on-the-use-of-a-few-layer-graphene-sno-2-nanocomposite
#5
Solleti Goutham, Satish Bykkam, Kishor Kumar Sadasivuni, Devarai Santhosh Kumar, Mohsen Ahmadipour, Zainal Arifin Ahmad, Kalagadda Venkateswara Rao
A nanocomposite consisting of a few layers of graphene (FLG) and tin dioxide (SnO2 ) was prepared by ultrasound-assisted synthesis. The uniform SnO2 nanoparticles (NPs) on the FLG were characterized by X-ray diffraction in terms of lattice and phase structure. The functional groups present in the composite were analyzed by FTIR. Electron microscopy (HR-TEM and FE-SEM) was used to study the morphology. The effect of the fraction of FLG present in the nanocomposite was investigated. Sensitivity, selectivity and reproducibility towards resistive sensing of liquid propane gas (LPG) was characterized by the I-V method...
December 20, 2017: Mikrochimica Acta
https://www.readbyqxmd.com/read/29572615/precision-medicine-for-crc-patients-in-the-veteran-population-state-of-the-art-challenges-and-research-directions
#6
REVIEW
Shyam S Mohapatra, Surinder K Batra, Srinivas Bharadwaj, Michael Bouvet, Bard Cosman, Ajay Goel, Wilma Jogunoori, Michael J Kelley, Lopa Mishra, Bibhuti Mishra, Subhra Mohapatra, Bhaumik Patel, Joseph R Pisegna, Jean-Pierre Raufman, Shuyun Rao, Hemant Roy, Maren Scheuner, Satish Singh, Gitanjali Vidyarthi, Jon White
Colorectal cancer (CRC) accounts for ~9% of all cancers in the Veteran population, a fact which has focused a great deal of the attention of the VA's research and development efforts. A field-based meeting of CRC experts was convened to discuss both challenges and opportunities in precision medicine for CRC. This group, designated as the VA Colorectal Cancer Cell-genomics Consortium (VA4C), discussed advances in CRC biology, biomarkers, and imaging for early detection and prevention. There was also a discussion of precision treatment involving fluorescence-guided surgery, targeted chemotherapies and immunotherapies, and personalized cancer treatment approaches...
March 23, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29565842/initial-public-health-laboratory-response-after-hurricane-maria-puerto-rico-2017
#7
Jeniffer Concepción-Acevedo, Anita Patel, Carolina Luna-Pinto, Rafael González Peña, Rosa Ivette Cuevas Ruiz, Héctor Rivera Arbolay, Mayra Toro, Carmen Deseda, Victor R De Jesus, Efrain Ribot, Jennifer-Quiñones Gonzalez, Gouthami Rao, Alfonsina De Leon Salazar, Marisela Ansbro, Brunilís B White, Margaret C Hardy, Joaudimir Castro Georgi, Rita Stinnett, Alexandra M Mercante, David Lowe, Haley Martin, Angela Starks, Beverly Metchock, Stephanie Johnston, Tracy Dalton, Olga Joglar, Cortney Stafford, Monica Youngblood, Katherine Klein, Stephen Lindstrom, LaShondra Berman, Renee Galloway, Ilana J Schafer, Henry Walke, Robyn Stoddard, Robin Connelly, Elaine McCaffery, Marie-Claire Rowlinson, Stephen Soroka, Darin T Tranquillo, Anne Gaynor, Chris Mangal, Kelly Wroblewski, Atis Muehlenbachs, Reynolds M Salerno, Matthew Lozier, Brittany Sunshine, Craig Shapiro, Dale Rose, Renee Funk, Satish K Pillai, Eduardo O'Neill
Hurricane Maria made landfall in Puerto Rico on September 20, 2017, causing major damage to infrastructure and severely limiting access to potable water, electric power, transportation, and communications. Public services that were affected included operations of the Puerto Rico Department of Health (PRDOH), which provides critical laboratory testing and surveillance for diseases and other health hazards. PRDOH requested assistance from CDC for the restoration of laboratory infrastructure, surveillance capacity, and diagnostic testing for selected priority diseases, including influenza, rabies, leptospirosis, salmonellosis, and tuberculosis...
March 23, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29537139/interrogation-of-an-autofluorescence-based-method-for-protein-fingerprinting
#8
Manjunath Siddaramaiah, Bola Sadashiva S Rao, Manjunath B Joshi, Anirbit Datta, S Sandya, Vasudha Vishnumurthy, Subhash Chandra, Subramanya G Nayak, Kapaettu Satyamoorthy, Krishna K Mahato
In the present study, we have designed a laser-induced fluorescence (LIF) based instrumentation and developed a sensitive methodology for the effective separation, visualization, identification and analysis of proteins on a single platform. In this method, intrinsic fluorescence spectra of proteins were detected after separation on 1 or 2 dimensional Sodium Dodecyl Sulfate-Tris(2-carboxyethyl)phosphine (SDS-TCEP) polyacrylamide gel electrophoresis (PAGE) and the data were analyzed. The MATLAB assisted software was designed for the development of PAGE fingerprint for the visualization of protein after 1- and 2-dimensional protein separation...
March 14, 2018: Journal of Biophotonics
https://www.readbyqxmd.com/read/29535445/reply-to-satta-et-al
#9
Ali Rezaie, Satish S Rao
No abstract text is available yet for this article.
March 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29454453/rectal-emr-for-enteric-ganglia-is-deeper-better
#10
EDITORIAL
Christine Yu, Satish S C Rao
No abstract text is available yet for this article.
March 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29453382/rectal-exam-yes-it-can-and-should-be-done-in-a-busy-practice
#11
Satish S C Rao
No abstract text is available yet for this article.
February 16, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29447119/pharmacological-approach-to-increasing-the-retention-of-radiation-induced-%C3%AE-h2ax-foci-using-phosphatase-inhibitors-significance-in-radiation-biodosimetry
#12
Akshaykumar A Nayak, Kamalesh Dattaram Mumbrekar, B S Satish Rao
In a scenario of accidental mass radiation exposure transportation and analysis of samples may take some time, resulting in loss of biomarker information over this period. The present study aims to use phosphatase inhibitors for longer retention of focal signals to adopt γ-H2AX as a biodosimetric biomarker for the management of early triage. Peripheral blood lymphocytes isolated from healthy individuals were irradiated in vitro with x-rays and γ-H2AX foci were analysed using fluorescent microscopy and flow cytometric methods...
February 15, 2018: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/29442908/systemic-toxicity-and-teratogenicity-of-copper-oxide-nanoparticles-and-copper-sulfate
#13
Ambika Vishnu Kadammattil, Shyama Prasad Sajankila, Suma Prabhu, Bhuvanagiri Nageshwar Rao, Bola Sadashiva Satish Rao
Acceleration in development of metallic nanoparticles for their utility in medical and technological applications due to their unique physicochemical properties has concurrently raised a matter of concern due to their potential toxicity. Of the enormous metallic nanostructures, copper oxide nanoparticles (CuONPs) having optical and electrochemical properties are scrutinized for theranostic applications. Therefore, their safety profile is of a major concern in optimizing a safe dose for its clinical utility...
April 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29437300/design-of-highly-potent-dual-acting-and-central-nervous-system-penetrating-hiv-1-protease-inhibitors-with-excellent-potency-against-multidrug-resistant-hiv-1-variants
#14
Arun K Ghosh, Kalapala Venkateswara Rao, Prasanth R Nyalapatla, Satish Kovela, Margherita Brindisi, Heather L Osswald, Bhavanam Sekhara Reddy, Johnson Agniswamy, Yuan-Fang Wang, Manabu Aoki, Shin-Ichiro Hattori, Irene T Weber, Hiroaki Mitsuya
Herein we report the design, synthesis, X-ray structural, and biological studies of an exceptionally potent HIV-1 protease inhibitor, compound 5 ((3S,7aS,8S)-hexahydro-4H-3,5-methanofuro[2,3-b]pyran-8-yl ((2S,3R)-4-((2-(cyclopropylamino)-N-isobutylbenzo[d]thiazole)-6-sulfonamido)-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl)carbamate). Using structure-based design, we incorporated an unprecedented 6-5-5-ring-fused crown-like tetrahydropyranofuran as the P2-ligand, a cyclopropylaminobenzothiazole as the P2'-ligand, and a 3,5-difluorophenylmethyl group as the P1-ligand...
April 23, 2018: ChemMedChem
https://www.readbyqxmd.com/read/29396286/genetic-variants-in-post-myocardial-infarction-patients-presenting-with-electrical-storm-of-unstable-ventricular-tachycardia
#15
Advithi Rangaraju, Shuba Krishnan, G Aparna, Satish Sankaran, Ashraf U Mannan, B Hygriv Rao
Electrical storm (ES) is a life threatening clinical situation. Though a few clinical pointers exist, the occurrence of ES in a patient with remote myocardial infarction (MI) is generally unpredictable. Genetic markers for this entity have not been studied. In the present study, we carried out genetic screening in patients with remote myocardial infarction presenting with ES by next generation sequencing and identified 25 rare variants in 19 genes predominantly in RYR2, SCN5A, KCNJ11, KCNE1 and KCNH2, CACNA1B, CACNA1C, CACNA1D and desmosomal genes - DSP and DSG2 that could potentially be implicated in electrical storm...
January 30, 2018: Indian Pacing and Electrophysiology Journal
https://www.readbyqxmd.com/read/29383790/xpnpep3-is-a-novel-transcriptional-target-of-canonical-wnt-%C3%AE-catenin-signaling
#16
Raju Kumar, Viswakalyan Kotapalli, Ashmala Naz, Swarnalata Gowrishankar, Satish Rao, Jonathan R Pollack, Murali Dharan Bashyam
Canonical Wnt/β-catenin signaling plays important roles in embryonic development and adult tissue regeneration while aberrant Wnt activation is the major driver of sporadic colorectal cancer (CRC). Thus, it is important to characterize the complete β-catenin target transcriptome. We previously performed microarray-based mRNA profiling of rectal cancer samples stratified for Wnt status. In addition to AXIN2 and EPHB2, XPNPEP3 transcripts were significantly elevated in tumors exhibiting activated Wnt/β-catenin signaling, validated by Q-PCR...
June 2018: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/29369813/yoga-versus-physical-exercise-for-cardio-respiratory-fitness-in-adolescent-school-children-a-randomized-controlled-trial
#17
Vhavle Satish, Raghavendra Mohan Rao, Nandi Krishnamurthy Manjunath, Ram Amritanshu, Udupa Vivek, Hassan Ratnakar Shreeganesh, Shashidhara Deepashree
Background Yoga is very effective in improving health especially cardio-respiratory fitness and also overall performance in adolescents. There are no large numbers of randomized controlled studies conducted on comparing yoga with physical activity for cardio-respiratory fitness in adolescent school children with large sample size. Objective Aerobic training is known to improve physical and cardio-respiratory fitness in children. Cardio-respiratory fitness is an important indicator of health in children. In this study we evaluate the effects of yoga versus physical exercise training on cardio-respiratory fitness in adolescent school children...
January 25, 2018: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/29353813/pharmacological-approach-to-increase-the-retention-of-radiation-induced-gamma-h2ax-foci-using-phosphatase-inhibitors-significance-in-radiation-biodosimetry
#18
Akshaykumar A Nayak, Kamalesh Dattaram Mumbrekar, Satish Rao
In a scenario of accidental mass radiation exposure, transportation and analyzing samples may take its time resulting in loss of biomarker information over this period. The present study aims to use phosphatases inhibitors for longer retention of foci signals to adopt γ-H2AX as a biodosimetric biomarker for the management of early triage. Peripheral blood lymphocytes isolated from healthy individuals irradiated in vitro with X-rays, and γ-H2AX analysed using fluorescent microscopy and flow cytometric methods...
January 22, 2018: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/29350301/constipation-in-parkinson-s-disease-a-nuisance-or-nuanced-answer-to-the-pathophysiological-puzzle
#19
REVIEW
Amol Sharma, Julie Kurek, John C Morgan, Chandramohan Wakade, Satish S C Rao
PURPOSE OF REVIEW: Chronic constipation is a common, nonmotor, and prodromal symptom in Parkinson's disease (PD). Its underlying neuropathology may provide pathophysiological insight into PD. Here, we critically review what is currently known about the neuroanatomical and brain-gut interactions, and the origin and progression of Lewy pathology (LP) at three levels-brain/brainstem, spinal cord, and enteric nervous system. RECENT FINDINGS: Many recent studies have illustrated the challenges of examining LP in tissues obtained from colon biopsies of PD patients...
January 19, 2018: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/29347691/dynamics-of-functional-failures-and-recovery-in-complex-road-networks
#20
Xianyuan Zhan, Satish V Ukkusuri, P Suresh C Rao
We propose a new framework for modeling the evolution of functional failures and recoveries in complex networks, with traffic congestion on road networks as the case study. Differently from conventional approaches, we transform the evolution of functional states into an equivalent dynamic structural process: dual-vertex splitting and coalescing embedded within the original network structure. The proposed model successfully explains traffic congestion and recovery patterns at the city scale based on high-resolution data from two megacities...
November 2017: Physical Review. E
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