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Magnus Simren

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https://www.readbyqxmd.com/read/28286196/-coping-skills-are-associated-with-gastrointestinal-symptom-severity-and-somatization-in-patients-with-irritable-bowel-syndrome
#1
Katarina Wilpart, Hans Törnblom, Jan Svedlund, Jan F Tack, Magnus Simrén, Lukas Van Oudenhove
BACKGROUND & AIMS: Coping resources and processes are altered in patients with irritable bowel syndrome (IBS). We investigated the relationship between coping resources and gastrointestinal (GI) and extra-intestinal symptom severity in patients with IBS as well as potential mediators of this relationship. METHODS: We performed a cross-sectional study of 216 patients with IBS attending a secondary/tertiary care specialized outpatient center in Sweden from 2003 through 2007...
March 7, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28276814/irritable-bowel-syndrome-what-do-the-new-rome-iv-diagnostic-guidelines-mean-for-patient-management
#2
William E Whitehead, Olafur S Palsson, Magnus Simrén
No abstract text is available yet for this article.
April 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28267193/nya-riktlinjer-f%C3%A3-r-handl%C3%A3-ggning-av-dyspepsi-h-pylori-och-mags%C3%A3-r
#3
Lars Agreus, Magnus Simrén
New Swedish guidelines for the management of dyspepsia, H pylori, and duodenal and gastric ulcers The management of dyspepsia in Sweden differs between national county councils, and is often not in line with international recommendations. The Swedish Society of Gastroenterology has together with the Swedish College of General Practice (SFAM) developed new national guidelines for the management of uninvestigated dyspepsia, functional dyspepsia, Helicobacter pylori, and uncomplicated duodenal and gastric ulcers...
February 28, 2017: Läkartidningen
https://www.readbyqxmd.com/read/28257307/small-intestinal-bacterial-overgrowth-as-a-cause-for-irritable-bowel-syndrome-guilty-or-not-guilty
#4
Imran Aziz, Hans Törnblom, Magnus Simrén
PURPOSE OF REVIEW: Small intestinal bacterial overgrowth (SIBO) has been proposed as a cause of irritable bowel syndrome (IBS). However, this relationship has been subject to controversy. This review aims to provide a current perspective on the SIBO-IBS hypothesis. RECENT FINDINGS: Case-control studies evaluating the prevalence of SIBO in IBS and healthy individuals have shown conflicting results. Moreover, the tests available in routine clinical practice to diagnose SIBO are not valid and lack both sensitivity and specificity...
March 2, 2017: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/28104632/visceral-hypersensitivity-is-associated-with-gi-symptom-severity-in-functional-gi-disorders-consistent-findings-from-five-different-patient-cohorts
#5
Magnus Simrén, Hans Törnblom, Olafur S Palsson, Miranda A L van Tilburg, Lukas Van Oudenhove, Jan Tack, William E Whitehead
OBJECTIVE: Our aim was to evaluate the association between visceral hypersensitivity and GI symptom severity in large cohorts of patients with functional GI disorder (FGID) and to adjust for psychological factors and general tendency to report symptoms. DESIGN: We included five cohorts of patients with FGIDs (IBS or functional dyspepsia; n=1144), who had undergone visceral sensitivity testing using balloon distensions (gastric fundus, descending colon or rectum) and completed questionnaires to assess GI symptom severity, non-GI somatic symptoms, anxiety and depression...
January 19, 2017: Gut
https://www.readbyqxmd.com/read/28087657/european-consensus-conference-on-faecal-microbiota-transplantation-in-clinical-practice
#6
Giovanni Cammarota, Gianluca Ianiro, Herbert Tilg, Mirjana Rajilić-Stojanović, Patrizia Kump, Reetta Satokari, Harry Sokol, Perttu Arkkila, Cristina Pintus, Ailsa Hart, Jonathan Segal, Marina Aloi, Luca Masucci, Antonio Molinaro, Franco Scaldaferri, Giovanni Gasbarrini, Antonio Lopez-Sanroman, Alexander Link, Pieter de Groot, Willem M de Vos, Christoph Högenauer, Peter Malfertheiner, Eero Mattila, Tomica Milosavljević, Max Nieuwdorp, Maurizio Sanguinetti, Magnus Simren, Antonio Gasbarrini
Faecal microbiota transplantation (FMT) is an important therapeutic option for Clostridium difficile infection. Promising findings suggest that FMT may play a role also in the management of other disorders associated with the alteration of gut microbiota. Although the health community is assessing FMT with renewed interest and patients are becoming more aware, there are technical and logistical issues in establishing such a non-standardised treatment into the clinical practice with safety and proper governance...
April 2017: Gut
https://www.readbyqxmd.com/read/27990484/initial-experience-of-video-capsule-endoscopy-after-intestinal-transplantation
#7
Jonas Varkey, Mihai Oltean, Andreas Bernd Pischel, Magnus Simrén, Gustaf Herlenius
BACKGROUND: Intestinal transplantation is a procedure which inflicts immunological and infectious complications that affect the transplanted graft, posing both diagnostic and therapeutic challenges. Video capsule endoscopy (VCE) offers easy access to the entire small intestine and presents itself as an interesting option. However, at present, no studies evaluating the usefulness of video capsule endoscopies in this setting have been published. Our aim was to evaluate the usefulness of VCE in detecting complications that arise after intestinal transplantation...
December 2016: Transplantation Direct
https://www.readbyqxmd.com/read/27957327/altered-expression-of-butyrophilin-btn-and-btn-like-btnl-genes-in-intestinal-inflammation-and-colon-cancer
#8
Cristina Lebrero-Fernández, Ulf Alexander Wenzel, Paulina Akeus, Ying Wang, Hans Strid, Magnus Simrén, Bengt Gustavsson, Lars G Börjesson, Susanna L Cardell, Lena Öhman, Marianne Quiding-Järbrink, Anna Bas-Forsberg
Several Butyrophilin (BTN) and Btn-like (BTNL) molecules control T lymphocyte responses, and are genetically associated with inflammatory disorders and cancer. In this study, we present a comprehensive expression analysis of human and murine BTN and BTNL genes in conditions associated with intestinal inflammation and cancer. Using real-time PCR, expression of human BTN and BTNL genes was analyzed in samples from patients with ulcerative colitis, irritable bowel syndrome, and colon tumors. Expression of murine Btn and Btnl genes was examined in mouse models of spontaneous colitis (Muc2(-/-)) and intestinal tumorigenesis (Apc(Min/+))...
June 2016: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/27922565/a-perspective-on-brain-gut-communication-the-american-gastroenterology-association-and-american-psychosomatic-society-joint-symposium-on-brain-gut-interactions-and-the-intestinal-microenvironment
#9
Olga C Aroniadis, Douglas A Drossman, Magnus Simren
BACKGROUND: Alterations in brain-gut communication and the intestinal microenvironment have been implicated in a variety of medical and neuropsychiatric diseases. Three central areas require basic and clinical research: (1) how the intestinal microenvironment interacts with the host immune system, central nervous system and enteric nervous system; (2) the role of the intestinal microenvironment in the pathogenesis of medical and neuropsychiatric disease; (3) the effects of diet, prebiotics, probiotics and fecal microbiota transplantation on the intestinal microenvironment and the treatment of disease...
January 17, 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/27884662/integrity-of-central-nervous-function-in-diabetes-mellitus-assessed-by-resting-state-eeg-frequency-analysis-and-source-localization
#10
Jens B Frøkjær, Carina Graversen, Christina Brock, Ahmad Khodayari-Rostamabad, Søren S Olesen, Tine M Hansen, Eirik Søfteland, Magnus Simrén, Asbjørn M Drewes
Diabetes mellitus (DM) is associated with structural and functional changes of the central nervous system. We used electroencephalography (EEG) to assess resting state cortical activity and explored associations to relevant clinical features. Multichannel resting state EEG was recorded in 27 healthy controls and 24 patients with longstanding DM and signs of autonomic dysfunction. The power distribution based on wavelet analysis was summarized into frequency bands with corresponding topographic mapping. Source localization analysis was applied to explore the electrical cortical sources underlying the EEG...
November 6, 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27872184/functional-variants-in-the-sucrase-isomaltase-gene-associate-with-increased-risk-of-irritable-bowel-syndrome
#11
Maria Henström, Lena Diekmann, Ferdinando Bonfiglio, Fatemeh Hadizadeh, Eva-Maria Kuech, Maren von Köckritz-Blickwede, Louise B Thingholm, Tenghao Zheng, Ghazaleh Assadi, Claudia Dierks, Martin Heine, Ute Philipp, Ottmar Distl, Mary E Money, Meriem Belheouane, Femke-Anouska Heinsen, Joseph Rafter, Gerardo Nardone, Rosario Cuomo, Paolo Usai-Satta, Francesca Galeazzi, Matteo Neri, Susanna Walter, Magnus Simrén, Pontus Karling, Bodil Ohlsson, Peter T Schmidt, Greger Lindberg, Aldona Dlugosz, Lars Agreus, Anna Andreasson, Emeran Mayer, John F Baines, Lars Engstrand, Piero Portincasa, Massimo Bellini, Vincenzo Stanghellini, Giovanni Barbara, Lin Chang, Michael Camilleri, Andre Franke, Hassan Y Naim, Mauro D'Amato
OBJECTIVE: IBS is a common gut disorder of uncertain pathogenesis. Among other factors, genetics and certain foods are proposed to contribute. Congenital sucrase-isomaltase deficiency (CSID) is a rare genetic form of disaccharide malabsorption characterised by diarrhoea, abdominal pain and bloating, which are features common to IBS. We tested sucrase-isomaltase (SI) gene variants for their potential relevance in IBS. DESIGN: We sequenced SI exons in seven familial cases, and screened four CSID mutations (p...
November 21, 2016: Gut
https://www.readbyqxmd.com/read/27845338/internet-delivered-cognitive-behavior-therapy-for-adolescents-with-irritable-bowel-syndrome-a-randomized-controlled-trial
#12
Marianne Bonnert, Ola Olén, Maria Lalouni, Marc A Benninga, Matteo Bottai, Johanna Engelbrektsson, Erik Hedman, Fabian Lenhard, Bo Melin, Magnus Simrén, Sarah Vigerland, Eva Serlachius, Brjánn Ljótsson
OBJECTIVES: Few treatments have been able to effectively manage pediatric irritable bowel syndrome (IBS). Internet-delivered cognitive behavior therapy (Internet-CBT) based on exposure for abdominal symptoms is effective for adult IBS. The objective of this study was to evaluate the efficacy of Internet-CBT based on behavioral exposure for adolescents with IBS. METHODS: Adolescents with IBS fulfilling the Rome III criteria were randomized to either Internet-CBT or a wait-list control...
January 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27725146/identification-of-an-intestinal-microbiota-signature-associated-with-severity-of-irritable-bowel-syndrome
#13
Julien Tap, Muriel Derrien, Hans Törnblom, Rémi Brazeilles, Stéphanie Cools-Portier, Joël Doré, Stine Störsrud, Boris Le Nevé, Lena Öhman, Magnus Simrén
BACKGROUND & AIMS: We have limited knowledge about the association between the composition of the intestinal microbiota and clinical features of irritable bowel syndrome (IBS). We collected information on the fecal and mucosa-associated microbiota of patients with IBS and evaluated whether these were associated with symptoms. METHODS: We collected fecal and mucosal samples from adult patients who met the Rome III criteria for IBS at a secondary/tertiary care outpatient clinics in Sweden, as well as from healthy subjects...
January 2017: Gastroenterology
https://www.readbyqxmd.com/read/27636379/ibs-like-symptoms-in-patients-with-ulcerative-colitis-in-deep-remission-are-associated-with-increased-levels-of-serum-cytokines-and-poor-psychological-well-being
#14
Börje Jonefjäll, Lena Öhman, Magnus Simrén, Hans Strid
BACKGROUND: Gastrointestinal symptoms (GI) compatible with irritable bowel syndrome (IBS) are common in patients with ulcerative colitis (UC) in remission. The causes of these symptoms remain to be clarified. Our aim was to investigate prevalence and factors associated with IBS-like symptoms in patients with UC in deep remission. METHODS: We included 298 patients with UC and used Mayo score, sigmoidoscopy, and fecal calprotectin to define deep remission versus active disease...
November 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27218818/patients-experiences-of-healthcare-encounters-in-severe-irritable-bowel-syndrome-an-analysis-based-on-narrative-and-feminist-theory
#15
Ida Björkman, Magnus Simrén, Gisela Ringström, Eva Jakobsson Ung
AIMS AND OBJECTIVES: This study aimed to explore patients' experiences of healthcare encounters in severe irritable bowel syndrome. BACKGROUND: Irritable bowel syndrome is a common functional disorder with symptoms such as abdominal pain and disturbed bowel habits, the cause of which is not completely known. Treatments options are limited, and healthcare encounters in irritable bowel syndrome have been described as unsatisfying and frustrating for both patients and professional healthcare providers...
October 2016: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/27159638/irritable-bowel-syndrome
#16
Paul Enck, Qasim Aziz, Giovanni Barbara, Adam D Farmer, Shin Fukudo, Emeran A Mayer, Beate Niesler, Eamonn M M Quigley, Mirjana Rajilić-Stojanović, Michael Schemann, Juliane Schwille-Kiuntke, Magnus Simren, Stephan Zipfel, Robin C Spiller
Irritable bowel syndrome (IBS) is a functional gastrointestinal disease with a high population prevalence. The disorder can be debilitating in some patients, whereas others may have mild or moderate symptoms. The most important single risk factors are female sex, younger age and preceding gastrointestinal infections. Clinical symptoms of IBS include abdominal pain or discomfort, stool irregularities and bloating, as well as other somatic, visceral and psychiatric comorbidities. Currently, the diagnosis of IBS is based on symptoms and the exclusion of other organic diseases, and therapy includes drug treatment of the predominant symptoms, nutrition and psychotherapy...
March 24, 2016: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/27154893/treating-fecal-incontinence-an-unmet-need-in-primary-care-medicine
#17
William E Whitehead, Olafur S Palsson, Magnus Simren
Fecal incontinence affects up to 36% of primary care patients. Although effective treatments are available, doctors rarely screen for this condition and patients seldom volunteer complaints of fecal incontinence. Conservative management yields 60% improvement in symptoms and continence in 20% of patients. Referrals are currently being accepted for studies seeking to improve case detection and to support conservative management or self-care.
May 2016: North Carolina Medical Journal
https://www.readbyqxmd.com/read/27144628/centrally-mediated-disorders-of-gastrointestinal-pain
#18
Laurie Keefer, Douglas A Drossman, Elspeth Guthrie, Magnus Simrén, Kirsten Tillisch, Kevin Olden, Peter J Whorwell
Centrally Mediated Abdominal Pain Syndrome (CAPS), formerly known as Functional Abdominal Pain Syndrome, can be distinguished from other functional GI disorders by its strong central component and relative independence from motility disturbances. CAPS is a result of central sensitization with disinhibition of pain signals rather than increased peripheral afferent excitability. A newly described condition, Narcotic Bowel Syndrome (NBS)/Opioid-Induced GI Hyperalgesia, is characterized by the paradoxical development of or increases in abdominal pain associated with continuous or increasing dosages of opioids...
February 19, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27144627/bowel-disorders
#19
Fermín Mearin, Brian E Lacy, Lin Chang, William D Chey, Anthony J Lembo, Magnus Simren, Robin Spiller
Functional bowel disorders are highly prevalent disorders found worldwide. These disorders have the potential to affect all members of society, regardless of age, gender, race, creed, color or socioeconomic status. Improving our understanding of functional bowel disorders (FBD) is critical as they impose a negative economic impact to the global health care system in addition to reducing quality of life. Research in the basic and clinical sciences during the past decade has produced new information on the epidemiology, etiology, pathophysiology, diagnosis and treatment of FBDs...
February 18, 2016: Gastroenterology
https://www.readbyqxmd.com/read/26668749/reflecting-on-a-memorable-ueg-week-2015%C3%A2
#20
Magnus Simren
No abstract text is available yet for this article.
December 2015: United European Gastroenterology Journal
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