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Magnus Simren

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https://www.readbyqxmd.com/read/27922565/a-perspective-on-brain-gut-communication-the-american-gastroenterology-association-and-american-psychosomatic-society-joint-symposium-on-brain-gut-interactions-and-the-intestinal-microenvironment
#1
Olga C Aroniadis, Douglas A Drossman, Magnus Simren
BACKGROUND: Alterations in brain-gut communication and the intestinal microenvironment have been implicated in a variety of medical and neuropsychiatric diseases. Three central areas require basic and clinical research: (1) how the intestinal microenvironment interacts with the host immune system, central nervous system and enteric nervous system; (2) the role of the intestinal microenvironment in the pathogenesis of medical and neuropsychiatric disease; (3) the effects of diet, prebiotics, probiotics and fecal microbiota transplantation on the intestinal microenvironment and the treatment of disease...
December 2, 2016: Psychosomatic Medicine
https://www.readbyqxmd.com/read/27884662/integrity-of-central-nervous-function-in-diabetes-mellitus-assessed-by-resting-state-eeg-frequency-analysis-and-source-localization
#2
Jens B Frøkjær, Carina Graversen, Christina Brock, Ahmad Khodayari-Rostamabad, Søren S Olesen, Tine M Hansen, Eirik Søfteland, Magnus Simrén, Asbjørn M Drewes
Diabetes mellitus (DM) is associated with structural and functional changes of the central nervous system. We used electroencephalography (EEG) to assess resting state cortical activity and explored associations to relevant clinical features. Multichannel resting state EEG was recorded in 27 healthy controls and 24 patients with longstanding DM and signs of autonomic dysfunction. The power distribution based on wavelet analysis was summarized into frequency bands with corresponding topographic mapping. Source localization analysis was applied to explore the electrical cortical sources underlying the EEG...
November 6, 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27872184/functional-variants-in-the-sucrase-isomaltase-gene-associate-with-increased-risk-of-irritable-bowel-syndrome
#3
Maria Henström, Lena Diekmann, Ferdinando Bonfiglio, Fatemeh Hadizadeh, Eva-Maria Kuech, Maren von Köckritz-Blickwede, Louise B Thingholm, Tenghao Zheng, Ghazaleh Assadi, Claudia Dierks, Martin Heine, Ute Philipp, Ottmar Distl, Mary E Money, Meriem Belheouane, Femke-Anouska Heinsen, Joseph Rafter, Gerardo Nardone, Rosario Cuomo, Paolo Usai-Satta, Francesca Galeazzi, Matteo Neri, Susanna Walter, Magnus Simrén, Pontus Karling, Bodil Ohlsson, Peter T Schmidt, Greger Lindberg, Aldona Dlugosz, Lars Agreus, Anna Andreasson, Emeran Mayer, John F Baines, Lars Engstrand, Piero Portincasa, Massimo Bellini, Vincenzo Stanghellini, Giovanni Barbara, Lin Chang, Michael Camilleri, Andre Franke, Hassan Y Naim, Mauro D'Amato
OBJECTIVE: IBS is a common gut disorder of uncertain pathogenesis. Among other factors, genetics and certain foods are proposed to contribute. Congenital sucrase-isomaltase deficiency (CSID) is a rare genetic form of disaccharide malabsorption characterised by diarrhoea, abdominal pain and bloating, which are features common to IBS. We tested sucrase-isomaltase (SI) gene variants for their potential relevance in IBS. DESIGN: We sequenced SI exons in seven familial cases, and screened four CSID mutations (p...
November 21, 2016: Gut
https://www.readbyqxmd.com/read/27845338/internet-delivered-cognitive-behavior-therapy-for-adolescents-with-irritable-bowel-syndrome-a-randomized-controlled-trial
#4
Marianne Bonnert, Ola Olén, Maria Lalouni, Marc A Benninga, Matteo Bottai, Johanna Engelbrektsson, Erik Hedman, Fabian Lenhard, Bo Melin, Magnus Simrén, Sarah Vigerland, Eva Serlachius, Brjánn Ljótsson
OBJECTIVES: Few treatments have been able to effectively manage pediatric irritable bowel syndrome (IBS). Internet-delivered cognitive behavior therapy (Internet-CBT) based on exposure for abdominal symptoms is effective for adult IBS. The objective of this study was to evaluate the efficacy of Internet-CBT based on behavioral exposure for adolescents with IBS. METHODS: Adolescents with IBS fulfilling the Rome III criteria were randomized to either Internet-CBT or a wait-list control...
November 15, 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27725146/identification-of-an-intestinal-microbiota-signature-associated-with-severity-of-irritable-bowel-syndrome
#5
Julien Tap, Muriel Derrien, Hans Törnblom, Rémi Brazeilles, Stéphanie Cools-Portier, Joël Doré, Stine Störsrud, Boris Le Nevé, Lena Öhman, Magnus Simrén
BACKGROUND & AIMS: We have limited knowledge about the association between the composition of the intestinal microbiota and clinical features of irritable bowel syndrome (IBS). We collected information on the fecal and mucosa-associated microbiota of patients with IBS and evaluated whether these were associated with symptoms. METHODS: We collected fecal and mucosal samples from adult patients who met the Rome III criteria for IBS at secondary or tertiary care outpatient clinics in Sweden, as well as from healthy subjects...
October 7, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27636379/ibs-like-symptoms-in-patients-with-ulcerative-colitis-in-deep-remission-are-associated-with-increased-levels-of-serum-cytokines-and-poor-psychological-well-being
#6
Börje Jonefjäll, Lena Öhman, Magnus Simrén, Hans Strid
BACKGROUND: Gastrointestinal symptoms (GI) compatible with irritable bowel syndrome (IBS) are common in patients with ulcerative colitis (UC) in remission. The causes of these symptoms remain to be clarified. Our aim was to investigate prevalence and factors associated with IBS-like symptoms in patients with UC in deep remission. METHODS: We included 298 patients with UC and used Mayo score, sigmoidoscopy, and fecal calprotectin to define deep remission versus active disease...
November 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27218818/patients-experiences-of-healthcare-encounters-in-severe-irritable-bowel-syndrome-an-analysis-based-on-narrative-and-feminist-theory
#7
Ida Björkman, Magnus Simrén, Gisela Ringström, Eva Jakobsson Ung
AIMS AND OBJECTIVES: This study aimed to explore patients' experiences of healthcare encounters in severe irritable bowel syndrome. BACKGROUND: Irritable bowel syndrome is a common functional disorder with symptoms such as abdominal pain and disturbed bowel habits, the cause of which is not completely known. Treatments options are limited, and healthcare encounters in irritable bowel syndrome have been described as unsatisfying and frustrating for both patients and professional healthcare providers...
October 2016: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/27159638/irritable-bowel-syndrome
#8
Paul Enck, Qasim Aziz, Giovanni Barbara, Adam D Farmer, Shin Fukudo, Emeran A Mayer, Beate Niesler, Eamonn M M Quigley, Mirjana Rajilić-Stojanović, Michael Schemann, Juliane Schwille-Kiuntke, Magnus Simren, Stephan Zipfel, Robin C Spiller
Irritable bowel syndrome (IBS) is a functional gastrointestinal disease with a high population prevalence. The disorder can be debilitating in some patients, whereas others may have mild or moderate symptoms. The most important single risk factors are female sex, younger age and preceding gastrointestinal infections. Clinical symptoms of IBS include abdominal pain or discomfort, stool irregularities and bloating, as well as other somatic, visceral and psychiatric comorbidities. Currently, the diagnosis of IBS is based on symptoms and the exclusion of other organic diseases, and therapy includes drug treatment of the predominant symptoms, nutrition and psychotherapy...
2016: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/27154893/treating-fecal-incontinence-an-unmet-need-in-primary-care-medicine
#9
William E Whitehead, Olafur S Palsson, Magnus Simren
Fecal incontinence affects up to 36% of primary care patients. Although effective treatments are available, doctors rarely screen for this condition and patients seldom volunteer complaints of fecal incontinence. Conservative management yields 60% improvement in symptoms and continence in 20% of patients. Referrals are currently being accepted for studies seeking to improve case detection and to support conservative management or self-care.
May 2016: North Carolina Medical Journal
https://www.readbyqxmd.com/read/27144628/centrally-mediated-disorders-of-gastrointestinal-pain
#10
Laurie Keefer, Douglas A Drossman, Elspeth Guthrie, Magnus Simrén, Kirsten Tillisch, Kevin Olden, Peter J Whorwell
Centrally Mediated Abdominal Pain Syndrome (CAPS), formerly known as Functional Abdominal Pain Syndrome, can be distinguished from other functional GI disorders by its strong central component and relative independence from motility disturbances. CAPS is a result of central sensitization with disinhibition of pain signals rather than increased peripheral afferent excitability. A newly described condition, Narcotic Bowel Syndrome (NBS)/Opioid-Induced GI Hyperalgesia, is characterized by the paradoxical development of or increases in abdominal pain associated with continuous or increasing dosages of opioids...
February 19, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27144627/bowel-disorders
#11
Fermín Mearin, Brian E Lacy, Lin Chang, William D Chey, Anthony J Lembo, Magnus Simren, Robin Spiller
Functional bowel disorders are highly prevalent disorders found worldwide. These disorders have the potential to affect all members of society, regardless of age, gender, race, creed, color or socioeconomic status. Improving our understanding of functional bowel disorders (FBD) is critical as they impose a negative economic impact to the global health care system in addition to reducing quality of life. Research in the basic and clinical sciences during the past decade has produced new information on the epidemiology, etiology, pathophysiology, diagnosis and treatment of FBDs...
February 18, 2016: Gastroenterology
https://www.readbyqxmd.com/read/26668749/reflecting-on-a-memorable-ueg-week-2015%C3%A2
#12
Magnus Simren
No abstract text is available yet for this article.
December 2015: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/26602216/depression-and-somatization-are-associated-with-increased-postprandial-symptoms-in-patients-with-irritable-bowel%C3%A2-syndrome
#13
Lukas Van Oudenhove, Hans Törnblom, Stine Störsrud, Jan Tack, Magnus Simrén
BACKGROUND & AIMS: Patients with irritable bowel syndrome (IBS) have increased postprandial symptom responses and more psychosocial morbidities than healthy individuals. However, the relationship between psychosocial status and postprandial symptom responses in patients with IBS is unclear. We investigated this relationship in a prospective study of patients with IBS. METHODS: A total of 193 IBS patients, diagnosed according to Rome II (n = 126) or Rome III (n = 67) criteria, consumed a standard breakfast (540 kcal: 36% fat, 15% proteins, 49% carbohydrates, and 8...
April 2016: Gastroenterology
https://www.readbyqxmd.com/read/26535129/ueg-week-in-vienna-2016-advancing-science-linking-people
#14
Magnus Simrén
No abstract text is available yet for this article.
October 2015: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/26492847/lactulose-challenge-determines-visceral-sensitivity-and-severity-of-symptoms-in-patients-with-irritable-bowel-syndrome
#15
Boris Le Nevé, Rémi Brazeilles, Muriel Derrien, Julien Tap, Denis Guyonnet, Lena Ohman, Hans Törnblom, Magnus Simrén
BACKGROUND & AIMS: Patients with irritable bowel syndrome (IBS) can be assigned to groups with different gastrointestinal (GI) symptoms based on results from a combined nutrient and lactulose challenge. We aimed to identify factors that predict outcomes to this challenge and to determine whether this can be used in noninvasive assessment of visceral sensitivity in patients with IBS. METHODS: We performed a prospective study of 100 patients with IBS diagnosed according to Rome III criteria (all subtypes) and seen at a secondary or tertiary care center...
February 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/26448307/practical-management-of-irritable-bowel-syndrome-a-clinical-review
#16
REVIEW
Ellinor Almquist, Hans Törnblom, Magnus Simrén
Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder, frequently managed by general practitioners and gastroenterologists. It is a complex condition, characterized by abdominal pain or discomfort associated with altered bowel habits, and it affects 11% of the population worldwide. It has a profound effect on quality of life for many patients and poses a substantial cost to society. Due to the complexity and diversity of IBS, diagnosis and treatment can be challenging. Common drawbacks in diagnosing and treating this disorder include unnecessary tests, failure to establish trust in the physician-patient relationship and difficulties in explaining the diagnosis...
March 2016: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/26405698/a-pilot-study-of-the-effect-of-aloe-barbadensis-mill-extract-avh200%C3%A2-in-patients-with-irritable-bowel-syndrome-a-randomized-double-blind-placebo-controlled-study
#17
RANDOMIZED CONTROLLED TRIAL
Stine Størsrud, Irina Pontén, Magnus Simrén
BACKGROUND AND AIMS: Few effective treatment options exist for patients with irritable bowel syndrome (IBS), and many patients state the use of aloe vera products reduce their symptoms. The aim of this pilot study was to investigate the effect of Aloe barbadensis Mill. Extract (AVH200®) in adult patients with IBS in a randomized, double-blind, placebo controlled study. METHODS: Sixty-eight adult patients diagnosed with IBS according to the Rome III criteria were randomized to receive AVH200® or matching placebo for four weeks...
September 2015: Journal of Gastrointestinal and Liver Diseases: JGLD
https://www.readbyqxmd.com/read/26279847/are-the-definitions-for-chronic-diarrhoea-adequate-evaluation-of-two-different-definitions-in-patients-with-chronic-diarrhoea
#18
Per-Ove Stotzer, Hasse Abrahamsson, Antal Bajor, Anders Kilander, Riadh Sadik, Henrik Sjövall, Magnus Simrén
BACKGROUND: The classical definition of chronic diarrhoea is ≥3 defecations/day, with a stool weight of more than 200 g and duration of ≥4 weeks. However, with this definition many patients with substantial symptoms and pathology will be excluded from further investigations. As a consequence other definitions have been proposed, mainly based on evaluation of the stool form. OBJECTIVE: To evaluate the accuracy of the classic criteria for diarrhoea in comparison with a definition based on stool consistency, using the Bristol Stool Form Scale...
August 2015: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/26255043/diet-low-in-fodmaps-reduces-symptoms-of-irritable-bowel-syndrome-as-well-as-traditional-dietary-advice-a-randomized-controlled-trial
#19
RANDOMIZED CONTROLLED TRIAL
Lena Böhn, Stine Störsrud, Therese Liljebo, Lena Collin, Perjohan Lindfors, Hans Törnblom, Magnus Simrén
BACKGROUND & AIMS: A diet with reduced content of fermentable short-chain carbohydrates (fermentable oligo-, di-, monosaccharides, and polyols [FODMAPs]) has been reported to be effective in the treatment of patients with irritable bowel syndrome (IBS). However, there is no evidence of its superiority to traditional dietary advice for these patients. We compared the effects of a diet low in FODMAPs with traditional dietary advice in a randomized controlled trial of patients with IBS. METHODS: We performed a multi-center, parallel, single-blind study of 75 patients who met Rome III criteria for IBS and were enrolled at gastroenterology outpatient clinics in Sweden...
November 2015: Gastroenterology
https://www.readbyqxmd.com/read/26113178/in-search-for-a-disease-modifying-treatment-in-irritable-bowel-syndrome
#20
COMMENT
Hans Törnblom, Magnus Simrén
No abstract text is available yet for this article.
January 2016: Gut
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