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Magnus Simren

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https://www.readbyqxmd.com/read/29134969/the-prevalence-and-impact-of-overlapping-rome-iv-diagnosed-functional-gastrointestinal-disorders-on-somatization-quality-of-life-and-healthcare-utilization-a-cross-sectional-general-population-study-in-three-countries
#1
Imran Aziz, Olafur S Palsson, Hans Törnblom, Ami D Sperber, William E Whitehead, Magnus Simrén
OBJECTIVES: The population prevalence of Rome IV-diagnosed functional gastrointestinal disorders (FGIDs) and their cumulative effect on health impairment is unknown. METHODS: An internet-based cross-sectional health survey was completed by 5,931 of 6,300 general population adults from three English-speaking countries (2100 each from USA, Canada, and UK). Quota-based sampling was used to generate demographically balanced and population representative samples with regards to age, sex, and education level...
November 14, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29089619/mir-16-and-mir-103-impact-5-ht4-receptor-signalling-and-correlate-with-symptom-profile-in-irritable-bowel-syndrome
#2
Carolin Wohlfarth, Stefanie Schmitteckert, Janina D Härtle, Lesley A Houghton, Harsh Dweep, Marina Fortea, Ghazaleh Assadi, Alexander Braun, Tanja Mederer, Sarina Pöhner, Philip P Becker, Christine Fischer, Martin Granzow, Hubert Mönnikes, Emeran A Mayer, Gregory Sayuk, Guy Boeckxstaens, Mira M Wouters, Magnus Simrén, Greger Lindberg, Bodil Ohlsson, Peter Thelin Schmidt, Aldona Dlugosz, Lars Agreus, Anna Andreasson, Mauro D'Amato, Barbara Burwinkel, Justo Lorenzo Bermejo, Ralph Röth, Felix Lasitschka, Maria Vicario, Marco Metzger, Javier Santos, Gudrun A Rappold, Cristina Martinez, Beate Niesler
Irritable bowel syndrome (IBS) is a gut-brain disorder involving alterations in intestinal sensitivity and motility. Serotonin 5-HT4 receptors are promising candidates in IBS pathophysiology since they regulate gut motor function and stool consistency, and targeted 5-HT4R selective drug intervention has been proven beneficial in subgroups of patients. We identified a single nucleotide polymorphism (SNP) (rs201253747) c.*61 T > C within the 5-HT4 receptor gene HTR4 to be predominantly present in diarrhoea-IBS patients (IBS-D)...
October 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28814481/plausibility-criteria-for-putative-pathophysiological-mechanisms-in-functional-gastrointestinal-disorders-a-consensus-of-experts
#3
Jan Tack, Maura Corsetti, Michael Camilleri, Eamonn Mm Quigley, Magnus Simren, Hidekazu Suzuki, Nicholas J Talley, Hans Tornblom, Lukas Van Oudenhove
BACKGROUND AND AIMS: The functional gastrointestinal disorders (FGIDs) are extremely common conditions associated with a considerable personal, social and health economic burden. Managing FGIDs in clinical practice is challenging because of the uncertainty of symptom-based diagnosis, the high frequency of overlap between these conditions and the limited efficacy of available therapies. It has often been argued that successful drug development and management of FGIDs requires knowledge of the underlying pathophysiology...
August 16, 2017: Gut
https://www.readbyqxmd.com/read/28445247/the-mucosal-antibacterial-response-profile-and-fecal-microbiota-composition-are-linked-to-the-disease-course-in-patients-with-newly-diagnosed-ulcerative-colitis
#4
Maria K Magnusson, Hans Strid, Stefan Isaksson, Magnus Simrén, Lena Öhman
BACKGROUND: The clinical disease course of ulcerative colitis (UC) varies substantially between individuals and can currently not be reliably predicted. The gut microbiota and the host's immune defense are key players for gut homeostasis and may be linked to disease outcome. The aim of this study was to determine fecal microbiota composition and mucosal antibacterial response profile in untreated patients with newly diagnosed UC and the impact of these factors on disease course. METHODS: Stool samples and intestinal biopsies were obtained from therapy-naive newly diagnosed patients with UC...
April 25, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28422780/understanding-the-gut-microbiota-in-inflammatory-and-functional-gastrointestinal-diseases
#5
Johanna Sundin, Lena Öhman, Magnus Simren
OBJECTIVE: During the last decade experimental and observational studies have shown that patients with Inflammatory Bowel Disease (IBD) and Irritable Bowel Syndrome (IBS) may have an altered intestinal microbial composition compared to healthy subjects. However, no uniform microbial signature has as yet been detected for either IBD or IBS. This review summarizes the current knowledge of microbial dysbiosis, and its potential relationship to the pathophysiology in IBD and IBS. METHODS: A selective review was conducted to summarize the current knowledge of gut microbiota in the pathophysiology of IBD and IBS...
April 18, 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/28416515/multivariate-modelling-of-faecal-bacterial-profiles-of-patients-with-ibs-predicts-responsiveness-to-a-diet-low-in-fodmaps
#6
Sean M P Bennet, Lena Böhn, Stine Störsrud, Therese Liljebo, Lena Collin, Perjohan Lindfors, Hans Törnblom, Lena Öhman, Magnus Simrén
OBJECTIVE: The effects of dietary interventions on gut bacteria are ambiguous. Following a previous intervention study, we aimed to determine how differing diets impact gut bacteria and if bacterial profiles predict intervention response. DESIGN: Sixty-seven patients with IBS were randomised to traditional IBS (n=34) or low fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs) (n=33) diets for 4 weeks. Food intake was recorded for 4 days during screening and intervention...
April 17, 2017: Gut
https://www.readbyqxmd.com/read/28403981/management-of-the-multiple-symptoms-of-irritable-bowel-syndrome
#7
REVIEW
Magnus Simrén, Hans Törnblom, Olafur S Palsson, William E Whitehead
Irritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorders. A stepwise management approach is advocated for patients with IBS. For a substantial proportion of patients with mild symptoms, general management principles, including making a confident diagnosis and offering explanation, reassurance, and dietary and lifestyle advice, are sufficient. However, many patients continue to have moderate-to-severe symptoms and are not satisfied solely with this approach. In these patients, use of pharmacotherapy on the basis of the predominant symptom (constipation, diarrhoea, pain, or bloating) or combination of symptoms is the next step...
February 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28374308/update-on-rome-iv-criteria-for-colorectal-disorders-implications-for-clinical-practice
#8
REVIEW
Magnus Simren, Olafur S Palsson, William E Whitehead
PURPOSE OF REVIEW: The purpose of the review was to provide an update of the Rome IV criteria for colorectal disorders with implications for clinical practice. RECENT FINDINGS: The Rome diagnostic criteria are expert consensus criteria for diagnosing functional gastrointestinal disorders (FGIDs). The current version, Rome IV, was released in May of 2016 after Rome III had been in effect for a decade. It is the collective product of committees that included more than 100 leading functional GI experts...
April 2017: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/28344800/how-to-get-your-work-published-tricks-and-pearls
#9
Gianluca Ianiro, Magnus Simren
No abstract text is available yet for this article.
March 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28286196/coping-skills-are-associated-with-gastrointestinal-symptom-severity-and-somatization-in-patients-with-irritable-bowel%C3%A2-syndrome
#10
Katarina Wilpart, Hans Törnblom, Jan Svedlund, Jan F Tack, Magnus Simrén, Lukas Van Oudenhove
BACKGROUND & AIMS: Coping resources and processes are altered in patients with irritable bowel syndrome (IBS). We investigated the relationship between coping resources and gastrointestinal (GI) and extraintestinal symptom severity in patients with IBS and potential mediators of this relationship. METHODS: We performed a cross-sectional study of 216 patients with IBS attending a secondary/tertiary care specialized outpatient center in Sweden from 2003 through 2007...
March 7, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28276814/irritable-bowel-syndrome-what-do-the-new-rome-iv-diagnostic-guidelines-mean-for-patient-management
#11
William E Whitehead, Olafur S Palsson, Magnus Simrén
No abstract text is available yet for this article.
April 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28267193/nya-riktlinjer-f%C3%A3-r-handl%C3%A3-ggning-av-dyspepsi-h-pylori-och-mags%C3%A3-r
#12
Lars Agreus, Magnus Simrén
New Swedish guidelines for the management of dyspepsia, H pylori, and duodenal and gastric ulcers The management of dyspepsia in Sweden differs between national county councils, and is often not in line with international recommendations. The Swedish Society of Gastroenterology has together with the Swedish College of General Practice (SFAM) developed new national guidelines for the management of uninvestigated dyspepsia, functional dyspepsia, Helicobacter pylori, and uncomplicated duodenal and gastric ulcers...
February 28, 2017: Läkartidningen
https://www.readbyqxmd.com/read/28257307/small-intestinal-bacterial-overgrowth-as-a-cause-for-irritable-bowel-syndrome-guilty-or-not-guilty
#13
Imran Aziz, Hans Törnblom, Magnus Simrén
PURPOSE OF REVIEW: Small intestinal bacterial overgrowth (SIBO) has been proposed as a cause of irritable bowel syndrome (IBS). However, this relationship has been subject to controversy. This review aims to provide a current perspective on the SIBO-IBS hypothesis. RECENT FINDINGS: Case-control studies evaluating the prevalence of SIBO in IBS and healthy individuals have shown conflicting results. Moreover, the tests available in routine clinical practice to diagnose SIBO are not valid and lack both sensitivity and specificity...
May 2017: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/28104632/visceral-hypersensitivity-is-associated-with-gi-symptom-severity-in-functional-gi-disorders-consistent-findings-from-five-different-patient-cohorts
#14
Magnus Simrén, Hans Törnblom, Olafur S Palsson, Miranda A L van Tilburg, Lukas Van Oudenhove, Jan Tack, William E Whitehead
OBJECTIVE: Our aim was to evaluate the association between visceral hypersensitivity and GI symptom severity in large cohorts of patients with functional GI disorder (FGID) and to adjust for psychological factors and general tendency to report symptoms. DESIGN: We included five cohorts of patients with FGIDs (IBS or functional dyspepsia; n=1144), who had undergone visceral sensitivity testing using balloon distensions (gastric fundus, descending colon or rectum) and completed questionnaires to assess GI symptom severity, non-GI somatic symptoms, anxiety and depression...
January 19, 2017: Gut
https://www.readbyqxmd.com/read/28087657/european-consensus-conference-on-faecal-microbiota-transplantation-in-clinical-practice
#15
Giovanni Cammarota, Gianluca Ianiro, Herbert Tilg, Mirjana Rajilić-Stojanović, Patrizia Kump, Reetta Satokari, Harry Sokol, Perttu Arkkila, Cristina Pintus, Ailsa Hart, Jonathan Segal, Marina Aloi, Luca Masucci, Antonio Molinaro, Franco Scaldaferri, Giovanni Gasbarrini, Antonio Lopez-Sanroman, Alexander Link, Pieter de Groot, Willem M de Vos, Christoph Högenauer, Peter Malfertheiner, Eero Mattila, Tomica Milosavljević, Max Nieuwdorp, Maurizio Sanguinetti, Magnus Simren, Antonio Gasbarrini
Faecal microbiota transplantation (FMT) is an important therapeutic option for Clostridium difficile infection. Promising findings suggest that FMT may play a role also in the management of other disorders associated with the alteration of gut microbiota. Although the health community is assessing FMT with renewed interest and patients are becoming more aware, there are technical and logistical issues in establishing such a non-standardised treatment into the clinical practice with safety and proper governance...
April 2017: Gut
https://www.readbyqxmd.com/read/27990484/initial-experience-of-video-capsule-endoscopy-after-intestinal-transplantation
#16
Jonas Varkey, Mihai Oltean, Andreas Bernd Pischel, Magnus Simrén, Gustaf Herlenius
BACKGROUND: Intestinal transplantation is a procedure which inflicts immunological and infectious complications that affect the transplanted graft, posing both diagnostic and therapeutic challenges. Video capsule endoscopy (VCE) offers easy access to the entire small intestine and presents itself as an interesting option. However, at present, no studies evaluating the usefulness of video capsule endoscopies in this setting have been published. Our aim was to evaluate the usefulness of VCE in detecting complications that arise after intestinal transplantation...
December 2016: Transplantation Direct
https://www.readbyqxmd.com/read/27957327/altered-expression-of-butyrophilin-btn-and-btn-like-btnl-genes-in-intestinal-inflammation-and-colon-cancer
#17
Cristina Lebrero-Fernández, Ulf Alexander Wenzel, Paulina Akeus, Ying Wang, Hans Strid, Magnus Simrén, Bengt Gustavsson, Lars G Börjesson, Susanna L Cardell, Lena Öhman, Marianne Quiding-Järbrink, Anna Bas-Forsberg
Several Butyrophilin (BTN) and Btn-like (BTNL) molecules control T lymphocyte responses, and are genetically associated with inflammatory disorders and cancer. In this study, we present a comprehensive expression analysis of human and murine BTN and BTNL genes in conditions associated with intestinal inflammation and cancer. Using real-time PCR, expression of human BTN and BTNL genes was analyzed in samples from patients with ulcerative colitis, irritable bowel syndrome, and colon tumors. Expression of murine Btn and Btnl genes was examined in mouse models of spontaneous colitis (Muc2(-/-)) and intestinal tumorigenesis (Apc(Min/+))...
June 2016: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/27922565/a-perspective-on-brain-gut-communication-the-american-gastroenterology-association-and-american-psychosomatic-society-joint-symposium-on-brain-gut-interactions-and-the-intestinal-microenvironment
#18
Olga C Aroniadis, Douglas A Drossman, Magnus Simren
BACKGROUND: Alterations in brain-gut communication and the intestinal microenvironment have been implicated in a variety of medical and neuropsychiatric diseases. Three central areas require basic and clinical research: (1) how the intestinal microenvironment interacts with the host immune system, central nervous system and enteric nervous system; (2) the role of the intestinal microenvironment in the pathogenesis of medical and neuropsychiatric disease; (3) the effects of diet, prebiotics, probiotics and fecal microbiota transplantation on the intestinal microenvironment and the treatment of disease...
January 17, 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/27884662/integrity-of-central-nervous-function-in-diabetes-mellitus-assessed-by-resting-state-eeg-frequency-analysis-and-source-localization
#19
Jens B Frøkjær, Carina Graversen, Christina Brock, Ahmad Khodayari-Rostamabad, Søren S Olesen, Tine M Hansen, Eirik Søfteland, Magnus Simrén, Asbjørn M Drewes
Diabetes mellitus (DM) is associated with structural and functional changes of the central nervous system. We used electroencephalography (EEG) to assess resting state cortical activity and explored associations to relevant clinical features. Multichannel resting state EEG was recorded in 27 healthy controls and 24 patients with longstanding DM and signs of autonomic dysfunction. The power distribution based on wavelet analysis was summarized into frequency bands with corresponding topographic mapping. Source localization analysis was applied to explore the electrical cortical sources underlying the EEG...
November 6, 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27872184/functional-variants-in-the-sucrase-isomaltase-gene-associate-with-increased-risk-of-irritable-bowel-syndrome
#20
Maria Henström, Lena Diekmann, Ferdinando Bonfiglio, Fatemeh Hadizadeh, Eva-Maria Kuech, Maren von Köckritz-Blickwede, Louise B Thingholm, Tenghao Zheng, Ghazaleh Assadi, Claudia Dierks, Martin Heine, Ute Philipp, Ottmar Distl, Mary E Money, Meriem Belheouane, Femke-Anouska Heinsen, Joseph Rafter, Gerardo Nardone, Rosario Cuomo, Paolo Usai-Satta, Francesca Galeazzi, Matteo Neri, Susanna Walter, Magnus Simrén, Pontus Karling, Bodil Ohlsson, Peter T Schmidt, Greger Lindberg, Aldona Dlugosz, Lars Agreus, Anna Andreasson, Emeran Mayer, John F Baines, Lars Engstrand, Piero Portincasa, Massimo Bellini, Vincenzo Stanghellini, Giovanni Barbara, Lin Chang, Michael Camilleri, Andre Franke, Hassan Y Naim, Mauro D'Amato
OBJECTIVE: IBS is a common gut disorder of uncertain pathogenesis. Among other factors, genetics and certain foods are proposed to contribute. Congenital sucrase-isomaltase deficiency (CSID) is a rare genetic form of disaccharide malabsorption characterised by diarrhoea, abdominal pain and bloating, which are features common to IBS. We tested sucrase-isomaltase (SI) gene variants for their potential relevance in IBS. DESIGN: We sequenced SI exons in seven familial cases, and screened four CSID mutations (p...
November 21, 2016: Gut
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