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Douglas Drossman

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https://www.readbyqxmd.com/read/27922565/a-perspective-on-brain-gut-communication-the-american-gastroenterology-association-and-american-psychosomatic-society-joint-symposium-on-brain-gut-interactions-and-the-intestinal-microenvironment
#1
Olga C Aroniadis, Douglas A Drossman, Magnus Simren
BACKGROUND: Alterations in brain-gut communication and the intestinal microenvironment have been implicated in a variety of medical and neuropsychiatric diseases. Three central areas require basic and clinical research: (1) how the intestinal microenvironment interacts with the host immune system, central nervous system and enteric nervous system; (2) the role of the intestinal microenvironment in the pathogenesis of medical and neuropsychiatric disease; (3) the effects of diet, prebiotics, probiotics and fecal microbiota transplantation on the intestinal microenvironment and the treatment of disease...
December 2, 2016: Psychosomatic Medicine
https://www.readbyqxmd.com/read/27147121/rome-iv-functional-gi-disorders-disorders-of-gut-brain-interaction
#2
Douglas A Drossman, William L Hasler
No abstract text is available yet for this article.
May 2016: Gastroenterology
https://www.readbyqxmd.com/read/27144628/centrally-mediated-disorders-of-gastrointestinal-pain
#3
Laurie Keefer, Douglas A Drossman, Elspeth Guthrie, Magnus Simrén, Kirsten Tillisch, Kevin Olden, Peter J Whorwell
Centrally Mediated Abdominal Pain Syndrome (CAPS), formerly known as Functional Abdominal Pain Syndrome, can be distinguished from other functional GI disorders by its strong central component and relative independence from motility disturbances. CAPS is a result of central sensitization with disinhibition of pain signals rather than increased peripheral afferent excitability. A newly described condition, Narcotic Bowel Syndrome (NBS)/Opioid-Induced GI Hyperalgesia, is characterized by the paradoxical development of or increases in abdominal pain associated with continuous or increasing dosages of opioids...
February 19, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27144624/biopsychosocial-aspects-of-functional-gastrointestinal-disorders
#4
Lukas Van Oudenhove, Michael D Crowell, Douglas A Drossman, Albena D Halpert, Laurie Keefer, Jeffrey M Lackner, Tasha B Murphy, Bruce D Naliboff, Rona L Levy
In this paper, we provide a general framework for understanding the functional gastrointestinal disorders (FGID) from a biopsychosocial perspective. More specifically, we provide an overview of the recent research on how the complex interactions of environmental, psychological, and biological factors contribute to the development and maintenance of the FGID. We emphasize that considering and addressing all these factors is a conditio sine qua non for appropriate treatment of these conditions. First, we provide an overview of what is currently known about how each of these factors - the environment, including the influence of those in an individual's family, the individual's own psychological states and traits, and the individual's (neuro)physiological make-up - interact to ultimately result in the generation of FGID symptoms...
February 18, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27144617/functional-gastrointestinal-disorders-history-pathophysiology-clinical-features-and-rome-iv
#5
Douglas A Drossman
Functional gastrointestinal disorders (FGIDs), the most common diagnoses in gastroenterology are recognized by morphological and physiological abnormalities that often occur in combination including motility disturbance, visceral hypersensitivity, altered mucosal and immune function, altered gut microbiota and altered central nervous system processing. Research on these gut-brain interaction disorders is based on using specific diagnostic criteria. The Rome Foundation has played a pivotal role in creating diagnostic criteria thus operationalizing the dissemination of new knowledge in the field of FGIDs...
February 19, 2016: Gastroenterology
https://www.readbyqxmd.com/read/26350938/validity-and-reliability-of-the-japanese-version-of-the-rome-iii-diagnostic-questionnaire-for-irritable-bowel-syndrome-and-functional-dyspepsia
#6
Motoyori Kanazawa, Shigemi Nakajima, Tadayuki Oshima, William E Whitehead, Ami D Sperber, Olafur S Palsson, Douglas A Drossman, Hiroto Miwa, Shin Fukudo
BACKGROUND/AIMS: Reliable diagnostic instruments for measuring the presence of functional gastrointestinal disorders based on the Rome III criteria have been lacking in Japan. The aims of the present study were to translate and validate the Rome III diagnostic questionnaire which was widely used in Western countries. METHODS: The original version of Rome III diagnostic questionnaire was translated from English into Japanese through 3 independent forward translations, resolution, back translation and reconciliation of the differences...
October 1, 2015: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/25952801/a-review-of-three-educational-projects-using-interactive-theater-to-improve-physician-patient-communication-when-treating-patients-with-irritable-bowel-syndrome
#7
Ben Saypol, Douglas A Drossman, Max J Schmulson, Carolina Olano, Albena Halpert, Ademola Aderoju, Lin Chang
BACKGROUND: Quality communication skills and increased multicultural sensitivity are universal goals, yet teaching them have remained a challenge for educators. OBJECTIVE: To document the process and participant responses to Interactive Theater when used as a method to teach physician/patient communication and cross-cultural competency. DESIGN, SETTING, AND PARTICIPANTS: Three projects are reported. They were collaborations between Theater Delta, the UNC Center for Functional GI and Motility Disorders, the Rome Foundation, the World Gastroenterology Organization, and the American Gastroenterological Association...
May 2015: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/25356996/definitions-and-outcome-measures-of-clinical-trials-regarding-opioid-induced-constipation-a-systematic-review
#8
REVIEW
Jan Gaertner, Waldemar Siemens, Michael Camilleri, Andrew Davies, Douglas A Drossman, Lynn R Webster, Gerhild Becker
Opioid-induced constipation (OIC) is a frequent symptom in patients treated with opioids and impacts the patients' quality of life. However, there is no generally accepted definition for OIC. The aims of this study were to identify definitions for OIC in clinical trials and Cochrane Reviews and to compile assessment tools and outcome measures that were used in clinical trials. In a systematic review, 5 databases (MEDLINE, PubMed, The Cochrane Library, Web of Science, and EMBASE) were searched to identify clinical trials assessing OIC in adult patients or healthy volunteers...
January 2015: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/25349684/prevalence-of-narcotic-bowel-syndrome-in-opioid-abusers-in-iran
#9
Bizhan Ahmadi, Peyman Arab, Mohammad Javad Zahedi, Sara Shafieipour, Douglas A Drossman, Ghodseyeh Banivaheb
BACKGROUND In spite of the increasing trend in opioid abusers worldwide, the prevalence of narcotic bowel syndrome (NBS) is undetermined. We aimed to estimate the prevalence of NBS and other opioid bowel dysfunction (OBD) in opioid abusers in Kerman, southeast Iran. According to the best of our knowledge, this is the first study to assess the prevalence of NBS in opioid abusers. METHODS By referring to addiction treatment centers in Kerman city and in a cross-sectional study, 577 subjects with opium or opioid subtracts abuse were included in our study...
October 2014: Middle East Journal of Digestive Diseases
https://www.readbyqxmd.com/read/25207609/the-narcotic-bowel-syndrome-a-recent-update
#10
REVIEW
Douglas Drossman, Eva Szigethy
OBJECTIVES: The paradoxical development of chronic abdominal pain is an underrecognized side effect of opioid use. Narcotic bowel syndrome (NBS), occurring in a small proportion of chronic opioid users, consists of chronic or intermittent abdominal pain, which often increases in severity despite continued or escalating dosages of opioids prescribed to relieve pain. METHODS: A PubMed search was conducted using terms such as "narcotic bowel syndrome" and "opioid hyperalgesia" through January 2014...
September 10, 2014: American Journal of Gastroenterology Supplements (Print)
https://www.readbyqxmd.com/read/25183577/narcotic-bowel-syndrome-and-opioid-induced-constipation
#11
REVIEW
Eva Szigethy, Marc Schwartz, Douglas Drossman
Prescription opioid use for chronic non-cancer pain has reached epidemic levels in the USA. With this increased use is the recognition of serious opioid-related gastrointestinal complications such as narcotic bowel syndrome (NBS) and opioid-induced constipation (OIC). NBS consists of a paradoxical worsening of abdominal pain with escalating doses of opioids and is likely mediated by the central nervous system. Therapy requires an intensive multidisciplinary approach to detoxification. OIC is the most common gastrointestinal side effect of opioids...
October 2014: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/24951847/redux-do-little-bellyachers-grow-up-to-become-big-bellyachers
#12
EDITORIAL
Douglas A Drossman
No abstract text is available yet for this article.
December 2014: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/24867013/effect-of-endoscopic-sphincterotomy-for-suspected-sphincter-of-oddi-dysfunction-on-pain-related-disability-following-cholecystectomy-the-episod-randomized-clinical-trial
#13
RANDOMIZED CONTROLLED TRIAL
Peter B Cotton, Valerie Durkalski, Joseph Romagnuolo, Qi Pauls, Evan Fogel, Paul Tarnasky, Giuseppe Aliperti, Martin Freeman, Richard Kozarek, Priya Jamidar, Mel Wilcox, Jose Serrano, Olga Brawman-Mintzer, Grace Elta, Patrick Mauldin, Andre Thornhill, Robert Hawes, April Wood-Williams, Kyle Orrell, Douglas Drossman, Patricia Robuck
IMPORTANCE: Abdominal pain after cholecystectomy is common and may be attributed to sphincter of Oddi dysfunction. Management often involves endoscopic retrograde cholangiopancreatography (ERCP) with manometry and sphincterotomy. OBJECTIVE: To determine whether endoscopic sphincterotomy reduces pain and whether sphincter manometric pressure is predictive of pain relief. DESIGN, SETTING, AND PATIENTS: Multicenter, sham-controlled, randomized trial involving 214 patients with pain after cholecystectomy without significant abnormalities on imaging or laboratory studies, and no prior sphincter treatment or pancreatitis randomly assigned (August 6, 2008-March 23, 2012) to undergo sphincterotomy or sham therapy at 7 referral medical centers...
May 2014: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/24751914/diagnosis-and-treatment-of-narcotic-bowel-syndrome
#14
REVIEW
Jacob E Kurlander, Douglas A Drossman
With increased prescription of opioids has come increased recognition of adverse consequences, including narcotic bowel syndrome (NBS). Characterized by incompletely controlled abdominal pain despite continued or increasing doses of opioids, NBS is estimated to occur in 4.2-6.4% of patients chronically taking opioids. Patients with NBS have a high degree of comorbid psychiatric illness, catastrophizing and disability; comorbid substance abuse must also be considered among this population. NBS should be distinguished from opioid-induced bowel disorder, which results from the effects of opioids on gastrointestinal motility and secretion...
July 2014: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/24714103/treatment-of-residual-inflammatory-bowel-disease-symptoms-with-low-dose-tricyclic-antidepressants-why-not
#15
EDITORIAL
Douglas A Drossman
No abstract text is available yet for this article.
May 2014: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/24472759/can-patient-and-pain-characteristics-predict-manometric-sphincter-of-oddi-dysfunction-in-patients-with-clinically-suspected-sphincter-of-oddi-dysfunction
#16
RANDOMIZED CONTROLLED TRIAL
Joseph Romagnuolo, Peter B Cotton, Valerie Durkalski, Qi Pauls, Olga Brawman-Mintzer, Douglas A Drossman, Patrick Mauldin, Kyle Orrell, April W Williams, Evan L Fogel, Paul R Tarnasky, Giuseppe Aliperti, Martin L Freeman, Richard A Kozarek, Priya A Jamidar, C Mel Wilcox, Jose Serrano, Grace H Elta
BACKGROUND: Biliopancreatic-type postcholecystectomy pain, without significant abnormalities on imaging and laboratory test results, has been categorized as "suspected" sphincter of Oddi dysfunction (SOD) type III. Clinical predictors of "manometric" SOD are important to avoid unnecessary ERCP, but are unknown. OBJECTIVE: To assess which clinical factors are associated with abnormal sphincter of Oddi manometry (SOM). DESIGN: Prospective, cross-sectional...
May 2014: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/24445573/psychosocial-characteristics-and-pain-burden-of-patients-with-suspected-sphincter-of-oddi-dysfunction-in-the-episod-multicenter-trial
#17
RANDOMIZED CONTROLLED TRIAL
Olga Brawman-Mintzer, Valerie Durkalski, Qi Wu, Joseph Romagnuolo, Evan Fogel, Paul Tarnasky, Giuseppe Aliperti, Martin Freeman, Richard Kozarek, Priya Jamidar, Mel Wilcox, Grace Elta, Kyle Orrell, April Wood, Patrick Mauldin, Jose Serrano, Douglas Drossman, Patricia Robuck, Peter Cotton
OBJECTIVES: Patients with several painful functional gastrointestinal disorders (FGIDs) are reported to have a high prevalence of psychosocial disturbance. These aspects have not been studied extensively in patients with suspected Sphincter of Oddi dysfunction (SOD). METHODS: A total of 214 patients with post-cholecystectomy pain and suspected SOD were enrolled in seven US centers in a multicenter-randomized trial (Evaluating Predictors and Interventions in Sphincter of Oddi Dysfunction)...
March 2014: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/24330412/evaluation-of-the-irritable-bowel-syndrome-quality-of-life-ibs-qol-questionnaire-in-diarrheal-predominant-irritable-bowel-syndrome-patients
#18
COMPARATIVE STUDY
David A Andrae, Donald L Patrick, Douglas A Drossman, Paul S Covington
BACKGROUND: Diarrhea-predominant irritable bowel syndrome (IBS-d) significantly diminishes the health-related quality of life (HRQOL) of patients. Psychological and social impacts are common with many IBS-d patients reporting comorbid depression, anxiety, decreased intimacy, and lost working days. The Irritable Bowel Syndrome Quality of Life (IBS-QOL) questionnaire is a 34-item instrument developed and validated for measurement of HRQOL in non-subtyped IBS patients. The current paper assesses this previously-validated instrument employing data collected from 754 patients who participated in a randomized clinical trial of a novel treatment, eluxadoline, for IBS-d...
December 13, 2013: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/24164903/impact-of-eating-restriction-on-gastrointestinal-motility-in-adolescents-with-ibs
#19
Miranda A L van Tilburg, John E Fortunato, Megan Squires, Douglas A Drossman, Christine Dalton, Steve Lichtman, William E Whitehead
OBJECTIVE: Gastrointestinal disturbances as a result of changes in eating patterns have been described in eating disorders. Many patients who experience irritable bowel syndrome report changes in eating patterns as a way to cope with their symptoms. Little is known about the consequences of these practices. The aim of this study was to explore whether repeated eating restriction (defined as not eating ≥ 4 hours while hungry) is associated with motility disturbances. METHODS: Of 17 patients with irritable bowel syndrome, subjects were divided into those who habitually restrict their eating (n = 8) and those without eating restriction (n = 9) (age range 15-21, mean 19...
April 2014: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/23623965/direct-trainee-observation-opportunities-for-enhanced-physician-patient-communication-and-faculty-development
#20
Madhusudan Grover, Douglas A Drossman, Amy S Oxentenko
No abstract text is available yet for this article.
June 2013: Gastroenterology
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