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Eamonn Quigley

Maria M Buckley, Rebecca O'Brien, Michelle Devlin, Aisling A Creed, Mark G Rae, Niall P Hyland, Eamonn M M Quigley, Declan P McKernan, Dervla O'Malley
In addition to its role in regulating energy homeostasis, the adipokine, leptin modifies gastrointestinal (GI) function. Indeed, leptin-resistant obese humans and leptin-deficient obese mice exhibit altered GI motility. In the functional GI disorder, irritable bowel syndrome (IBS), circulating leptin levels are reported to differ from healthy controls. Additionally, IBS patients display altered cytokine profiles, including elevated circulating levels of the pro-inflammatory cytokine, interleukin (IL)-6, which bears structural homology and similarities in intracellular signalling to leptin...
September 27, 2016: Experimental Physiology
Eamonn M M Quigley, Michael Fried, Kok-Ann Gwee, Igor Khalif, A P S Hungin, Greger Lindberg, Zaigham Abbas, Luis B Fernandez, Shobna J Bhatia, Max Schmulson, Carolina Olano, Anton LeMair
No abstract text is available yet for this article.
October 2016: Journal of Clinical Gastroenterology
Sara Iqbal, Eamonn M M Quigley
The investigation of the role of the microbial communities of our gastrointestinal tract (microbiota) has accelerated dramatically in recent years thanks to rapid developments in the technologies that allow us to fully enumerate and evaluate the full complement of bacterial species and strains that normally inhabit the gut. Laboratory studies in a range of inventive animal models continue to provide insights into the role of the microbiota in health and to generate plausible hypotheses relating to its potential involvement in the pathogenesis of human disease...
September 2016: Current Gastroenterology Reports
Juan J Martin-Viñas, Eamonn M M Quigley
OBJECTIVE: To systematically review the available data on cytokine and immune cells in the peripheral blood and mucosal biopsy samples from patients with IBS. METHODS: From a review of the literature, data on cytokines and immune cells that had been assayed in at least three independent studies were collated and trends examined. RESULTS: Levels of interleukin (IL)-10 tended to be decreased and those of IL6, IL8, tumor necrosis factor-alpha and IL-1 beta increased in the systemic circulation in IBS, while in the mucosa, IL-10 was decreased and IL-8, mast cells, enterochromaffin cells and CD3+ and CD8+ T lymphocytes cells were increased...
July 17, 2016: Journal of Digestive Diseases
Alberto O Barroso, Eamonn M M Quigley
Colonic diverticula are very common and may be associated with symptoms or complicated by diverticulitis and its associated problems. Many of the traditional concepts relating to the pathophysiology, prevention, and management of these entities have been questioned recently based on findings from high-quality prospective studies. Although dietary fiber may protect against symptoms and complications, its impact on the formation of diverticula may be limited. It is now evident that the risk for an episode of diverticulitis in an individual with diverticula is lower than previously thought...
October 2015: Gastroenterology & Hepatology
Paul Enck, Qasim Aziz, Giovanni Barbara, Adam D Farmer, Shin Fukudo, Emeran A Mayer, Beate Niesler, Eamonn M M Quigley, Mirjana Rajilić-Stojanović, Michael Schemann, Juliane Schwille-Kiuntke, Magnus Simren, Stephan Zipfel, Robin C Spiller
Irritable bowel syndrome (IBS) is a functional gastrointestinal disease with a high population prevalence. The disorder can be debilitating in some patients, whereas others may have mild or moderate symptoms. The most important single risk factors are female sex, younger age and preceding gastrointestinal infections. Clinical symptoms of IBS include abdominal pain or discomfort, stool irregularities and bloating, as well as other somatic, visceral and psychiatric comorbidities. Currently, the diagnosis of IBS is based on symptoms and the exclusion of other organic diseases, and therapy includes drug treatment of the predominant symptoms, nutrition and psychotherapy...
2016: Nature Reviews. Disease Primers
Giovanni Barbara, Christine Feinle-Bisset, Uday C Ghoshal, Eamonn M Quigley, Javier Santos, Steve Vanner, Nathalie Vergnolle, Erwin G Zoetendal
For decades, interactions between the enteric neuromuscular apparatus and the central nervous system have served as the primary focus of pathophysiological research in the functional gastrointestinal disorders. The accumulation of patient reports, as well as clinical observations, has belatedly led to an interest in the role of various luminal factors and their interactions with each other and the host in functional gastrointestinal disorders. Most prominent among these factors has been the role of food. As a consequence, while not always evidence-based, dietary interventions are enjoying a renaissance in irritable bowel syndrome management...
February 18, 2016: Gastroenterology
Michael Camilleri, Hubert Piessevaux, Yan Yiannakou, Jan Tack, René Kerstens, Eamonn M M Quigley, MeiYun Ke, Susana Da Silva, Amy Levine
BACKGROUND: Prucalopride, a selective, high-affinity 5-hydroxytryptamine 4 receptor agonist, stimulates gastrointestinal and colonic motility and alleviates common symptoms of chronic constipation (CC) in adults. The relative efficacy by gender has not been evaluated. AIM: To evaluate the global efficacy and safety of prucalopride 2 mg daily in men and women with CC using data from six large, randomized, controlled clinical trials. METHODS: Data were combined from six phase 3 and 4, double-blind, randomized, placebo-controlled, parallel-group trials...
August 2016: Digestive Diseases and Sciences
Valeria D Felice, Eamonn M Quigley, Aideen M Sullivan, Gerard W O'Keeffe, Siobhain M O'Mahony
Parkinson's disease is the second most common neurodegenerative disorder, affecting 1-2% of the population over 65 years of age. The primary neuropathology is the loss of midbrain dopaminergic neurons, resulting in characteristic motor deficits, upon which the clinical diagnosis is based. However, a number of significant non-motor symptoms (NMS) are also evident that appear to have a greater impact on the quality of life of these patients. In recent years, it has become increasingly apparent that neurobiological processes can be modified by the bi-directional communication that occurs along the brain-gut axis...
June 2016: Parkinsonism & related Disorders
Eamonn M M Quigley
Though distinct in terms of pathology, natural history and therapeutic approach, irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD) have some features in common. These include shared symptomatology and largely similar demographics. However, in most instances, clinical presentation, together with laboratory, imaging and endoscopic findings will readily permit the differentiation of active IBD from IBS. More problematic is the situation where a subject with IBD, in apparent remission, continues to complain of symptoms which, in aggregate, satisfy commonly employed criteria for the diagnosis of IBS...
March 2016: Therapeutic Advances in Gastroenterology
Joaquim Prado Moraes-Filho, Eamonn M M Quigley
Irritable bowel syndrome is a common, chronic relapsing gastrointestinal disorder that affects 7%-22% of the population worldwide. According to Rome III Criteria, the disorder is defined by the coexistence of abdominal discomfort or pain associated with an alteration in bowel habits. Its pathophysiology is not completely understood but, in addition to some important abnormalities, the disturbed intestinal microbiota has also been described supported by several strands of evidence. The treatment of irritable bowel syndrome is based upon several therapeutic approaches but few have been successful or without adverse events and more recently the gut microbiota and the use of probiotics have emerged as a factor to be considered...
December 2015: Arquivos de Gastroenterologia
Eamonn M M Quigley
PURPOSE OF REVIEW: This article evaluates the current status of the gut barrier in gastrointestinal disorders. RECENT FINDINGS: The gut barrier is a complex, multicomponent, interactive, and bidirectional entity that includes, but is not restricted to, the epithelial cell layer. Intestinal permeability, the phenomenon most readily and commonly studied, reflects just one (albeit an important one) function of the barrier that is intimately related to and interacts with luminal contents, including the microbiota...
March 2016: Current Opinion in Gastroenterology
Eamonn M M Quigley, Robin C Spiller
No abstract text is available yet for this article.
February 2016: Gastroenterology
Vineet S Gudsoorkar, Eamonn M M Quigley
No abstract text is available yet for this article.
May 2016: Clinical Gastroenterology and Hepatology
Eamonn M M Quigley, Leila Neshatian
INTRODUCTION: Chronic constipation is a global problem affecting all ages and associated with considerable morbidity and significant financial burden for society. Though formerly defined on the basis of a single symptom, infrequent defecation; constipation is now viewed as a syndrome encompassing several complaints such as difficulty with defecation, a sense of incomplete evacuation, hard stools, abdominal discomfort and bloating. AREAS COVERED: The expanded concept of constipation has inevitably led to a significant change in outcomes in clinical trials, as well as in patient expectations from new therapeutic interventions...
2016: Expert Opinion on Pharmacotherapy
Eamonn M M Quigley
No abstract text is available yet for this article.
January 2016: Current Opinion in Gastroenterology
Yuan Li, Xuefeng Xia, Jing Zhang, Zhiqiang Song, Liya Zhou, Yaopeng Zhang, Yonghui Huang, Yanyan Shi, Eamonn M M Quigley, Shigang Ding
Patients with inflammatory bowel disease (IBD) are at risk of developing haemophagocytic lymphohistiocytosis (HLH) because of chronic systemic inflammation as well as exposure to immunosuppressive medications. The two main causes of HLH in IBD patients are infection with cytomegalovirus and Epstein-Barr virus. Patients with Crohn's disease are more susceptible to HLH than those with ulcerative colitis. The majority of cases are seen in people receiving an immunosuppressive regimen that included thiopurines.
2015: Przegla̜d Gastroenterologiczny
Martin H Floch, W Allan Walker, Mary Ellen Sanders, Max Nieuwdorp, Adam S Kim, David A Brenner, Amir A Qamar, Tamir A Miloh, Alfredo Guarino, Mario Guslandi, Levinus A Dieleman, Yehuda Ringel, Eamonn M M Quigley, Lawrence J Brandt
This paper describes the consensus opinion of the participants in the 4th Triennial Yale/Harvard Workshop on Probiotic Recommendations. The recommendations update those of the first 3 meetings that were published in 2006, 2008, and 2011. Recommendations for the use of probiotics in necrotizing enterocolitis, childhood diarrhea, inflammatory bowel disease, irritable bowel syndrome and Clostridium difficile diarrhea are reviewed. In addition, we have added recommendations for liver disease for the first time...
November 2015: Journal of Clinical Gastroenterology
Eamonn M M Quigley
Although probiotics have been used for many years by those who suffer from what would now be defined as irritable bowel syndrome (IBS), a scientific rationale for their use in this indication and clinical evidence to support their benefits have only emerged very recently. Evidence to support considering strategies, such as probiotics, that modulate the gut microbiome, in IBS, has been provided by laboratory studies implicating the microbiome and the host response to the enteric microenvironment in IBS, as well as in vitro and in vivo studies demonstrating the ability of various commensal bacteria to influence such relevant functions as motility, visceral sensation, gut barrier integrity, and brain-gut interactions...
November 2015: Journal of Clinical Gastroenterology
Eamonn M Quigley, Howard P Monsour
With the recognition of the various metabolic functions of the gut microbiome and of its putative role in obesity, an investigation of the contribution of the bacterial populations of the gastrointestinal tract to the metabolic syndrome and its hepatic manifestation-nonalcoholic liver disease (NAFLD)-became inevitable. Furthermore, the central role of an altered microbiome in the precipitation of infectious and noninfectious complications of liver disease was described decades ago. The contribution of the microbiome to the pathogenesis of NAFLD has been extensively studied in animal models...
August 2015: Seminars in Liver Disease
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