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Eamonn Quigley

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https://www.readbyqxmd.com/read/29785650/a-probiotic-for-ulcerative-colitis-the-culture-wars-continue
#1
EDITORIAL
Bincy P Abraham, Eamonn M M Quigley
No abstract text is available yet for this article.
May 21, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29684976/pharmabiotic-manipulation-of-the-microbiota-in-gastrointestinal-disorders-a-clinical-perspective
#2
Fanny Giron, Eamonn M M Quigley
The advent and widespread availability of high-throughput technology has revolutionized the assessment of the communities of microorganisms that inhabit the gastrointestinal tract - the gut microbiota. As our understanding of the role of the microbiota in health and human disease increases so to do efforts to prevent and treat disease through the modulation of the microbiota. Several strategies are available to us and range from time honored approaches, such as antibiotics and probiotics, to changes in diet, the administration of prebiotics as food supplements and fecal microbiota transplantation...
April 24, 2018: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/29426776/therapeutic-implications-of-the-gastrointestinal-microbiome
#3
REVIEW
Purna C Kayshap, Eamonn Mm Quigley
Gut microbiome is an integral part of the metabolic machinery that contributes to normal host function. The advent of next generation sequencing technologies has allowed an in-depth investigation of the microbiome at various body sites including microbes which are challenging to culture. The same technologies have revealed the metabolic capacity of the microbiome, identified novel microbial products and suggested possible implications for human health. The gut microbiome has previously not been considered in aspects of human health such as response to medications, which may be metabolized to a varying extent by the microbiome, thereby, altering their efficacy and the incidence of adverse events...
February 6, 2018: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/29425782/carbohydrate-maldigestion-and-malabsorption
#4
Anam Omer, Eamonn M M Quigley
No abstract text is available yet for this article.
February 6, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29301380/the-gut-brain-axis-and-the-microbiome-clues-to-pathophysiology-and-opportunities-for-novel-management-strategies-in-irritable-bowel-syndrome-ibs
#5
REVIEW
Eamonn M M Quigley
Irritable bowel syndrome (IBS) is one of the most common of all medical disorders worldwide and, while for some it represents no more than a nuisance, for others it imposes significant negative impacts on daily life and activities. IBS is a heterogeneous disorder and may well have a number of causes which may lie anywhere from the external environment to the contents of the gut lumen and from the enteric neuromuscular apparatus and the gut immune system to the central nervous system. Consequently, the paradigm of the gut-brain axis, which includes the participation of these various factors, has proven a useful model to assist clinicians and patients alike in understanding the genesis of symptoms in IBS...
January 3, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29173520/probiotics-in-inflammatory-bowel-disease
#6
REVIEW
Bincy P Abraham, Eamonn M M Quigley
Evidence indicates that the gut microbiota and/or interactions between the microbiota and the host immune system are involved in the pathogenesis of inflammatory bowel disease (IBD). Strategies that target the microbiota have emerged as potential therapies and, of these, probiotics have gained the greatest attention. Data derived from animal models of IBD have revealed the potential of several bacterial strains to modify the natural history of IBD. However, thought there is some evidence for efficacy in ulcerative colitis and in pouchitis, in particular, there has been little indication that probiotics exert any benefit in Crohn disease...
December 2017: Gastroenterology Clinics of North America
https://www.readbyqxmd.com/read/29147138/an-update-on-prucalopride-in-the-treatment-of-chronic-constipation
#7
REVIEW
Anam Omer, Eamonn M M Quigley
Chronic constipation (CC) is a highly prevalent and often under-appreciated gastrointestinal disorder associated with significant impairment in quality of life. Symptoms of constipation are typically present for a number of years prior to a patient seeking help. Lifestyle modifications followed by, or coupled with, over-the-counter laxatives represent the initial treatment option; however, relief for many is limited and dissatisfaction rates for these approaches remain high. Over recent years, therefore, considerable effort has been exerted on the development of novel pharmacological approaches...
November 2017: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/29110286/the-better-understanding-and-recognition-of-the-disconnects-experiences-and-needs-of-patients-with-chronic-idiopathic-constipation-burden-cic-study-results-of-an-online-questionnaire
#8
Lucinda A Harris, John Horn, Michele Kissous-Hunt, Leslie Magnus, Eamonn M M Quigley
INTRODUCTION: There is limited literature comparing the experiences and attitudes of patients with chronic idiopathic constipation (CIC) to those of healthcare professionals (HCPs) treating CIC patients. The BURDEN-CIC study was conducted to better understand the experiences and ongoing needs of CIC patients and to assess their alignment versus disconnection with the perceptions and needs of HCPs who treat CIC patients. METHODS: The BURDEN-CIC study was an author-developed, online questionnaire that used KnowledgePanel® to survey individuals with CIC (n = 1223)...
December 2017: Advances in Therapy
https://www.readbyqxmd.com/read/29039142/microbiota-brain-gut-axis-and-neurodegenerative-diseases
#9
REVIEW
Eamonn M M Quigley
PURPOSE OF REVIEW: The purposes of this review were as follows: first, to provide an overview of the gut microbiota and its interactions with the gut and the central nervous system (the microbiota-gut-brain axis) in health, second, to review the relevance of this axis to the pathogenesis of neurodegenerative diseases, such as Parkinson's disease, and, finally, to assess the potential for microbiota-targeted therapies. RECENT FINDINGS: Work on animal models has established the microbiota-gut-brain axis as a real phenomenon; to date, the evidence for its operation in man has been limited and has been confronted by considerable logistical challenges...
October 17, 2017: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/28899670/definition-pathogenesis-and-management-of-that-cursed-dyspepsia
#10
REVIEW
Pramoda Koduru, Malcolm Irani, Eamonn M M Quigley
Dyspepsia is an umbrella term used to encompass a number of symptoms thought to originate from the upper gastrointestinal tract. These symptoms are relatively nonspecific; not surprisingly, therefore, a myriad of conditions may present with any one or a combination of these symptoms. Therein lays the clinician's first challenge: detecting the minority who may have a potentially life-threatening disorder, such as gastric cancer, from a population whose symptoms are, for the most part, considered functional in origin...
September 9, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28887755/prokinetics-in-the-management-of-functional-gastrointestinal-disorders
#11
REVIEW
Eamonn M M Quigley
PURPOSE OF REVIEW: The goal of this review is to review the current status of prokinetics and to place it in historical context. Impaired motility and thus propulsion have long been thought to play important roles in the pathogenesis of a number of gastrointestinal disorders including gastroesophageal reflux disease (GERD), gastroparesis, chronic idiopathic pseudo-obstruction, and constipation. Historically, disordered motility was also thought to contribute to a number of functional gastrointestinal disorders such as functional dyspepsia (FD) and irritable bowel syndrome (IBS)...
September 8, 2017: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/28814481/plausibility-criteria-for-putative-pathophysiological-mechanisms-in-functional-gastrointestinal-disorders-a-consensus-of-experts
#12
Jan Tack, Maura Corsetti, Michael Camilleri, Eamonn Mm Quigley, Magnus Simren, Hidekazu Suzuki, Nicholas J Talley, Hans Tornblom, Lukas Van Oudenhove
BACKGROUND AND AIMS: The functional gastrointestinal disorders (FGIDs) are extremely common conditions associated with a considerable personal, social and health economic burden. Managing FGIDs in clinical practice is challenging because of the uncertainty of symptom-based diagnosis, the high frequency of overlap between these conditions and the limited efficacy of available therapies. It has often been argued that successful drug development and management of FGIDs requires knowledge of the underlying pathophysiology...
August 16, 2017: Gut
https://www.readbyqxmd.com/read/28589613/the-role-of-the-microbiome-and-the-use-of-probiotics-in-gastrointestinal-disorders-in-adults-in-the-asia-pacific-region-background-and-recommendations-of-a-regional-consensus-meeting
#13
REVIEW
Uday C Ghoshal, Kok-Ann Gwee, Gerald Holtmann, Yanmei Li, Soo Jung Park, Marcellus Simadibrata, Kentaro Sugano, Kaichun Wu, Eamonn M M Quigley, Henry Cohen
The Asia-Pacific region is diverse, with regard to ethnicity, culture, and economic development incorporating some of the world's least and most developed nations. Gastrointestinal diseases are common in the Asia-Pacific region, and their prevalence, presentation, and management vary considerably within the region. There is growing evidence for an important role for the human gut microbiota in gastrointestinal health. As a consequence, geographic variations in the composition of the gut microbiota may contribute to variations in both the prevalence and response to therapy of specific diseases...
January 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28436237/bifidobacterium-infantis-35624-and-other-probiotics-in-the-management-of-irritable-bowel-syndrome-strain-specificity-symptoms-and-mechanisms
#14
Andrew P Allen, Gerard Clarke, John F Cryan, Eamonn M M Quigley, Timothy G Dinan
No abstract text is available yet for this article.
May 19, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28413018/plaa-mutations-cause-a-lethal-infantile-epileptic-encephalopathy-by-disrupting-ubiquitin-mediated-endolysosomal-degradation-of-synaptic-proteins
#15
Emma A Hall, Michael S Nahorski, Lyndsay M Murray, Ranad Shaheen, Emma Perkins, Kosala N Dissanayake, Yosua Kristaryanto, Ross A Jones, Julie Vogt, Manon Rivagorda, Mark T Handley, Girish R Mali, Tooba Quidwai, Dinesh C Soares, Margaret A Keighren, Lisa McKie, Richard L Mort, Noor Gammoh, Amaya Garcia-Munoz, Tracey Davey, Matthieu Vermeren, Diana Walsh, Peter Budd, Irene A Aligianis, Eissa Faqeih, Alan J Quigley, Ian J Jackson, Yogesh Kulathu, Mandy Jackson, Richard R Ribchester, Alex von Kriegsheim, Fowzan S Alkuraya, C Geoffrey Woods, Eamonn R Maher, Pleasantine Mill
During neurotransmission, synaptic vesicles undergo multiple rounds of exo-endocytosis, involving recycling and/or degradation of synaptic proteins. While ubiquitin signaling at synapses is essential for neural function, it has been assumed that synaptic proteostasis requires the ubiquitin-proteasome system (UPS). We demonstrate here that turnover of synaptic membrane proteins via the endolysosomal pathway is essential for synaptic function. In both human and mouse, hypomorphic mutations in the ubiquitin adaptor protein PLAA cause an infantile-lethal neurodysfunction syndrome with seizures...
May 4, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/28356581/gut-microbiome-as-a-clinical-tool-in-gastrointestinal-disease-management-are-we-there-yet
#16
REVIEW
Eamonn M M Quigley
Spurred on by ever-evolving developments in analytical methodology, the microbiome, and the gut microbiome in particular, has become the hot topic in biomedical research. Ingenious experiments in animal models have revealed the extent to which the gut microbiota sustains health and how its disruption might contribute to disease pathogenesis. Not surprisingly, associations between the microbiota and disease states in humans have been the subject of considerable interest and many links proposed. However, with rare exceptions, the incrimination of an altered microbiota in disease pathogenesis seems premature at this time given our incomplete understanding of the composition of the gut microbiota in health and the effect of many confounding factors in the interpretation of supposedly abnormal microbial signatures...
May 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28289500/olmesartan-induced-enteropathy
#17
Abimbola Adike, Juan Corral, David Rybnicek, Daniel Sussman, Samir Shah, Eamonn Quigley
Olmesartan-induced enteropathy mimics celiac disease clinically and pathologically. As in celiac disease, the pathologic findings are villous atrophy and increased intraepithelial lymphocytes. Clinical presentation of olmesartan-induced enteropathy includes diarrhea, weight loss, and nausea. In contrast to celiac disease, tissue transglutaminase is not elevated and there is no response to a gluten-free diet. Including this entity in the differential diagnosis of sprue-like enteropathy is critical for its early diagnosis since replacing olmesartan with an alternative antihypertensive drug can simplify the diagnostic workup and provide both clinical and histologic improvement...
October 2016: Methodist DeBakey Cardiovascular Journal
https://www.readbyqxmd.com/read/28265110/bifidobacterium-breve-with-%C3%AE-linolenic-acid-alters-the-composition-distribution-and-transcription-factor-activity-associated-with-metabolism-and-absorption-of-fat
#18
Elaine Patterson, Rebecca Wall, Sara Lisai, R Paul Ross, Timothy G Dinan, John F Cryan, Gerald F Fitzgerald, Sebastiano Banni, Eamonn M Quigley, Fergus Shanahan, Catherine Stanton
This study focused on the mechanisms that fatty acid conjugating strains - Bifidobacterium breve NCIMB 702258 and Bifidobacterium breve DPC 6330 - influence lipid metabolism when ingested with α-linolenic acid (ALA) enriched diet. Four groups of BALB/c mice received ALA enriched diet (3% (w/w)) either alone or in combination with B. breve NCIMB 702258 or B. breve DPC 6330 (10(9) CFU/day) or unsupplemented control diet for six weeks. The overall n-3 PUFA score was increased in all groups receiving the ALA enriched diet...
March 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28259791/irritable-bowel-syndrome-an-infectious-disease
#19
EDITORIAL
Eamonn M M Quigley, Anthony J Lembo
No abstract text is available yet for this article.
April 2017: Gastroenterology
https://www.readbyqxmd.com/read/28164857/preface
#20
EDITORIAL
Eamonn M M Quigley
No abstract text is available yet for this article.
March 2017: Gastroenterology Clinics of North America
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