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Eamonn Quigley

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https://www.readbyqxmd.com/read/28289500/olmesartan-induced-enteropathy
#1
Abimbola Adike, Juan Corral, David Rybnicek, Daniel Sussman, Samir Shah, Eamonn Quigley
Olmesartan-induced enteropathy mimics celiac disease clinically and pathologically. As in celiac disease, the pathologic findings are villous atrophy and increased intraepithelial lymphocytes. Clinical presentation of olmesartan-induced enteropathy includes diarrhea, weight loss, and nausea. In contrast to celiac disease, tissue transglutaminase is not elevated and there is no response to a gluten-free diet. Including this entity in the differential diagnosis of sprue-like enteropathy is critical for its early diagnosis since replacing olmesartan with an alternative antihypertensive drug can simplify the diagnostic workup and provide both clinical and histologic improvement...
October 2016: Methodist DeBakey Cardiovascular Journal
https://www.readbyqxmd.com/read/28265110/bifidobacterium-breve-with-%C3%AE-linolenic-acid-alters-the-composition-distribution-and-transcription-factor-activity-associated-with-metabolism-and-absorption-of-fat
#2
Elaine Patterson, Rebecca Wall, Sara Lisai, R Paul Ross, Timothy G Dinan, John F Cryan, Gerald F Fitzgerald, Sebastiano Banni, Eamonn M Quigley, Fergus Shanahan, Catherine Stanton
This study focused on the mechanisms that fatty acid conjugating strains - Bifidobacterium breve NCIMB 702258 and Bifidobacterium breve DPC 6330 - influence lipid metabolism when ingested with α-linolenic acid (ALA) enriched diet. Four groups of BALB/c mice received ALA enriched diet (3% (w/w)) either alone or in combination with B. breve NCIMB 702258 or B. breve DPC 6330 (10(9) CFU/day) or unsupplemented control diet for six weeks. The overall n-3 PUFA score was increased in all groups receiving the ALA enriched diet...
March 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28259791/irritable-bowel-syndrome-an-infectious-disease
#3
EDITORIAL
Eamonn M M Quigley, Anthony J Lembo
No abstract text is available yet for this article.
March 1, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28164857/preface
#4
EDITORIAL
Eamonn M M Quigley
No abstract text is available yet for this article.
March 2017: Gastroenterology Clinics of North America
https://www.readbyqxmd.com/read/28164844/basic-definitions-and-concepts-organization-of-the-gut-microbiome
#5
REVIEW
Eamonn M M Quigley
New claims are frequently made for a role for the microbiome in a disease or disorder previously considered remote from the gut. The microbiome has been linked to such seemingly unrelated entities as depression, anorexia nervosa, autism, Parkinson disease, allergy, and asthma. Although many of these proposals have been based on animal studies, explorations of the microbiome in human disease continue to proliferate, facilitated by technologies that provide a detailed assessment of the microbial inhabitants of our gastrointestinal tract and their biological activities and metabolic products...
March 2017: Gastroenterology Clinics of North America
https://www.readbyqxmd.com/read/28154380/a-vanishing-hematoma-an-unusual-cause-of-lower-gastrointestinal-bleeding
#6
Ali Raza, Eamonn M Quigley
No abstract text is available yet for this article.
February 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28146447/the-gut-response-to-food-a-physiological-perspective-on-food-induced-gastrointestinal-symptoms-it-s-not-all-allergy-and-intolerance
#7
Eamonn M M Quigley
No abstract text is available yet for this article.
March 2017: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/27997976/the-microbiome-what-will-the-future-hold
#8
Howard Paul Monsour, Eamonn M M Quigley
Current research on the human microbiome has opened our eyes to the intimate relationship that we have with the bacteria that populate our gastrointestinal tract and its potential relationship to health and disease. To date, clinical research on the microbiome has identified intriguing associations between an altered microbiome and disease states, but proven therapeutic applications have been very limited. The ingestion of prebiotics, probiotics, and/or synbiotics is appealing to the general public and has significant commercial value, but as yet, solid evidence for clinical efficacy in liver disease has been lacking due, in large part, to the paucity of high-quality clinical trials...
September 2016: Seminars in Liver Disease
https://www.readbyqxmd.com/read/27997975/primary-biliary-cirrhosis-and-the-microbiome
#9
Eamonn M M Quigley
Primary biliary cirrhosis is a rather uncommon, slowly progressive, cholestatic liver disease that predominantly affects middle-aged women. Apart from the changes in the gut microbiome that have been described in liver disease in general, little is known of the composition of the microbiome in primary biliary cirrhosis. Nevertheless, epidemiological, clinical, and some experimental evidence points to the possible role of a bacterium (or bacteria) in the initiation of the autoimmune process that leads to the development of this unique clinical phenotype...
September 2016: Seminars in Liver Disease
https://www.readbyqxmd.com/read/27997970/the-metabolic-role-of-the-microbiome-implications-for-nafld-and-the-metabolic-syndrome
#10
Eamonn M M Quigley, Ahmed Abu-Shanab, Eileen F Murphy, Catherine Stanton, Howard P Monsour
Nonalcoholic fatty liver disease (NAFLD) has rapidly emerged as one of the most prevalent liver diseases worldwide and is set to achieve virtually epidemic proportions if current trends in obesity continue. A considerable volume of data from animal experiments has revealed the magnitude of the metabolic contribution of the gut microbiome and how a disordered microbial population could contribute to the development of obesity and its complications, including NAFLD. Although considerable progress has been made in developing a role for the microbiome in NAFLD and nonalcoholic steatosis (NASH), there are still many issues to be resolved, including the nature and location of the altered microbiome (i...
September 2016: Seminars in Liver Disease
https://www.readbyqxmd.com/read/27997968/the-microbiome-and-the-liver-the-basics
#11
David W Victor, Eamonn M M Quigley
The relationships between the microbiota and other aspects of normal human biology continue to be explored. Indeed, the volume of information relating to the interplay between the host and the microbiota has grown exponentially-especially with the advent of ever-improving techniques for rapidly sequencing and identifying bacterial populations and their functions. The gut is initially sterile at birth and colonization and dynamic changes occur during infancy and early childhood in order to establish a mature microbiome...
September 2016: Seminars in Liver Disease
https://www.readbyqxmd.com/read/27798439/colonic-ischemia-usual-and-unusual-presentations-and-their-management
#12
Ayah Oglat, Eamonn M M Quigley
PURPOSE OF REVIEW: To provide an update on the epidemiology, pathophysiology, clinical presentation, and management of colonic ischemia. RECENT FINDINGS: Formerly regarded as a rare cause of lower gastrointestinal hemorrhage, colonic ischemia is now recognized to be the most common manifestation of intestinal vascular compromise. In contrast to ischemic events in the small intestine wherein thrombotic and embolic events predominate, colonic ischemia typically results from a global reduction in blood flow to the colon and no occlusive lesion(s) are evident...
January 2017: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/27676233/leptin-modifies-the-prosecretory-and-prokinetic-effects-of-the-inflammatory-cytokine-interleukin-6-on-colonic-function-in-sprague-dawley-rats
#13
Maria M Buckley, Rebecca O'Brien, Michelle Devlin, Aisling A Creed, Mark G Rae, Niall P Hyland, Eamonn M M Quigley, Declan P McKernan, Dervla O'Malley
What is the central question of this study? Does crosstalk exist between leptin and interleukin-6 in colonic enteric neurons, and is this a contributory factor in gastrointestinal dysfunction associated with irritable bowel syndrome? What is the main finding and its importance? Leptin ameliorates the prosecretory and prokinetic effects of the pro-inflammatory cytokine interleukin-6 on rat colon. Leptin also suppresses the neurostimulatory effects of irritable bowel syndrome plasma, which has elevated concentrations of interleukin-6, on enteric neurons...
December 1, 2016: Experimental Physiology
https://www.readbyqxmd.com/read/27623513/world-gastroenterology-organisation-global-guidelines-irritable-bowel-syndrome-a-global-perspective-update-september-2015
#14
Eamonn M M Quigley, Michael Fried, Kok-Ann Gwee, Igor Khalif, A P S Hungin, Greger Lindberg, Zaigham Abbas, Luis B Fernandez, Shobna J Bhatia, Max Schmulson, Carolina Olano, Anton LeMair
No abstract text is available yet for this article.
October 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27448618/progress-in-our-understanding-of-the-gut-microbiome-implications-for-the-clinician
#15
REVIEW
Sara Iqbal, Eamonn M M Quigley
The investigation of the role of the microbial communities of our gastrointestinal tract (microbiota) has accelerated dramatically in recent years thanks to rapid developments in the technologies that allow us to fully enumerate and evaluate the full complement of bacterial species and strains that normally inhabit the gut. Laboratory studies in a range of inventive animal models continue to provide insights into the role of the microbiota in health and to generate plausible hypotheses relating to its potential involvement in the pathogenesis of human disease...
September 2016: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/27426409/immune-response-in-irritable-bowel-syndrome-a-systematic-review-of-systemic-and-mucosal-inflammatory-mediators
#16
Juan J Martin-Viñas, Eamonn M M Quigley
OBJECTIVE: To systematically review the available data on cytokine and immune cells in the peripheral blood and mucosal biopsy samples from patients with irritable bowel syndrome (IBS). METHODS: From a review of the literature, data on cytokines and immune cells that had been assayed in at least three independent studies were collated and trends examined. RESULTS: Levels of interleukin (IL)-10 tended to be decreased and those of IL-6, IL-8, tumor necrosis factor-α and IL-1β increased in the systemic circulation in IBS, while in the mucosa, IL-10 was decreased and IL-8, mast cells, enterochromaffin cells and CD3(+) T lymphocytes were increased...
September 2016: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/27330495/diverticula-and-diverticulitis-time-for-a-reappraisal
#17
Alberto O Barroso, Eamonn M M Quigley
Colonic diverticula are very common and may be associated with symptoms or complicated by diverticulitis and its associated problems. Many of the traditional concepts relating to the pathophysiology, prevention, and management of these entities have been questioned recently based on findings from high-quality prospective studies. Although dietary fiber may protect against symptoms and complications, its impact on the formation of diverticula may be limited. It is now evident that the risk for an episode of diverticulitis in an individual with diverticula is lower than previously thought...
October 2015: Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27159638/irritable-bowel-syndrome
#18
Paul Enck, Qasim Aziz, Giovanni Barbara, Adam D Farmer, Shin Fukudo, Emeran A Mayer, Beate Niesler, Eamonn M M Quigley, Mirjana Rajilić-Stojanović, Michael Schemann, Juliane Schwille-Kiuntke, Magnus Simren, Stephan Zipfel, Robin C Spiller
Irritable bowel syndrome (IBS) is a functional gastrointestinal disease with a high population prevalence. The disorder can be debilitating in some patients, whereas others may have mild or moderate symptoms. The most important single risk factors are female sex, younger age and preceding gastrointestinal infections. Clinical symptoms of IBS include abdominal pain or discomfort, stool irregularities and bloating, as well as other somatic, visceral and psychiatric comorbidities. Currently, the diagnosis of IBS is based on symptoms and the exclusion of other organic diseases, and therapy includes drug treatment of the predominant symptoms, nutrition and psychotherapy...
March 24, 2016: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/27144620/the-intestinal-microenvironment-and-functional-gastrointestinal-disorders
#19
Giovanni Barbara, Christine Feinle-Bisset, Uday C Ghoshal, Eamonn M Quigley, Javier Santos, Steve Vanner, Nathalie Vergnolle, Erwin G Zoetendal
For decades, interactions between the enteric neuromuscular apparatus and the central nervous system have served as the primary focus of pathophysiological research in the functional gastrointestinal disorders. The accumulation of patient reports, as well as clinical observations, has belatedly led to an interest in the role of various luminal factors and their interactions with each other and the host in functional gastrointestinal disorders. Most prominent among these factors has been the role of food. As a consequence, while not always evidence-based, dietary interventions are enjoying a renaissance in irritable bowel syndrome management...
February 18, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27056037/efficacy-and-safety-of-prucalopride-in-chronic-constipation-an-integrated-analysis-of-six-randomized-controlled-clinical-trials
#20
Michael Camilleri, Hubert Piessevaux, Yan Yiannakou, Jan Tack, René Kerstens, Eamonn M M Quigley, MeiYun Ke, Susana Da Silva, Amy Levine
BACKGROUND: Prucalopride, a selective, high-affinity 5-hydroxytryptamine 4 receptor agonist, stimulates gastrointestinal and colonic motility and alleviates common symptoms of chronic constipation (CC) in adults. The relative efficacy by gender has not been evaluated. AIM: To evaluate the global efficacy and safety of prucalopride 2 mg daily in men and women with CC using data from six large, randomized, controlled clinical trials. METHODS: Data were combined from six phase 3 and 4, double-blind, randomized, placebo-controlled, parallel-group trials...
August 2016: Digestive Diseases and Sciences
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