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Anthony Lembo

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https://www.readbyqxmd.com/read/28417992/eluxadoline-efficacy-in-ibs-d-patients-who-report-prior-loperamide-use
#1
Brian E Lacy, William D Chey, Brooks D Cash, Anthony J Lembo, Leonard S Dove, Paul S Covington
OBJECTIVES: Irritable bowel syndrome with diarrhea (IBS-D) is often managed with over-the-counter therapies such as loperamide, though with limited success. This analysis evaluated the efficacy of eluxadoline in patients previously treated with loperamide in two phase 3 studies. METHODS: Adults with IBS-D (Rome III criteria) were enrolled and randomized to placebo or eluxadoline (75 or 100 mg) twice daily for 26 (IBS-3002) or 52 (IBS-3001) weeks. Patients reported loperamide use over the previous year and recorded their rescue loperamide use during the studies...
April 18, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28332105/emergency-department-burden-of-diverticulitis-in-the-usa-2006-2013
#2
Andrea Bollom, Jasmine Austrie, William Hirsch, Judy Nee, Daniel Friedlander, Kelli Ellingson, Vivian Cheng, Anthony Lembo
GOALS: The aim of this study was to analyze recent trends in emergency department (ED) visits for diverticulitis between 2006 and 2013. BACKGROUND: Acute diverticulitis is a serious medical condition that frequently leads to ED visits, hospitalizations, and surgeries resulting in a significant health care burden. METHODS: Data were obtained from the National Emergency Department Sample (NEDS) records in which diverticulitis (ICD-9-CM codes 562...
March 22, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28323273/hydrogen-and-methane-based-breath-testing-in-gastrointestinal-disorders-the-north-american-consensus
#3
Ali Rezaie, Michelle Buresi, Anthony Lembo, Henry Lin, Richard McCallum, Satish Rao, Max Schmulson, Miguel Valdovinos, Salam Zakko, Mark Pimentel
OBJECTIVES: Breath tests (BTs) are important for the diagnosis of carbohydrate maldigestion syndromes and small intestinal bacterial overgrowth (SIBO). However, standardization is lacking regarding indications for testing, test methodology and interpretation of results. A consensus meeting of experts was convened to develop guidelines for clinicians and research. METHODS: Pre-meeting survey questions encompassing five domains; indications, preparation, performance, interpretation of results, and knowledge gaps, were sent to 17 clinician-scientists, and 10 attended a live meeting...
March 21, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28259791/irritable-bowel-syndrome-an-infectious-disease
#4
EDITORIAL
Eamonn M M Quigley, Anthony J Lembo
No abstract text is available yet for this article.
March 1, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28244495/tenapanor-treatment-of-patients-with-constipation-predominant-irritable-bowel-syndrome-a-phase-2-randomized-placebo-controlled-efficacy-and-safety-trial
#5
William D Chey, Anthony J Lembo, David P Rosenbaum
OBJECTIVES: Tenapanor is a first-in-class, small-molecule inhibitor of the gastrointestinal sodium/hydrogen exchanger NHE3. This study assessed the efficacy and safety of tenapanor in patients with constipation-predominant irritable bowel syndrome (IBS-C). METHODS: In this phase 2, double-blind study, patients with IBS-C (Rome III criteria) were randomized (1:1:1:1) to receive tenapanor 5 mg, 20 mg, or 50 mg b.i.d., or placebo b.i.d. for 12 weeks. The primary end point was the complete spontaneous bowel movement (CSBM) responder rate, defined as the proportion of patients reporting an increase from baseline of ≥1 CSBM/week for ≥6/12 treatment weeks...
February 28, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28169091/predictors-of-excess-patient-radiation-exposure-during-chronic-total-occlusion-coronary-intervention-insights-from-a-contemporary-multicentre-registry
#6
Georgios E Christakopoulos, Georgios Christopoulos, Dimitri Karmpaliotis, Khaldoon Alaswad, Robert W Yeh, Farouc A Jaffer, Michael R Wyman, William L Lombardi, Muhammad Nauman J Tarar, J Aaron Grantham, David E Kandzari, Nicholas Lembo, Jeffrey W Moses, Ajay J Kirtane, Manish Parikh, Philip Green, Matthew Finn, Santiago Garcia, Anthony H Doing, Raja Hatem, Craig A Thompson, Subhash Banerjee, Emmanouil S Brilakis
BACKGROUND: High patient radiation dose during chronic total occlusion (CTO) percutaneous coronary intervention (PCI) might lead to procedural failure and radiation skin injury. METHODS: We examined the association between several clinical and angiographic variables on patient air kerma (AK) radiation dose among 748 consecutive CTO PCIs performed at 9 experienced US centres between May 2012 and May 2015. RESULTS: The mean age was 65 ± 10 years, 87% of patients were men, and 35% had previous coronary artery bypass graft surgery (CABG)...
April 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28110300/irritable-bowel-syndrome-and-diet
#7
REVIEW
Piero Portincasa, Leonilde Bonfrate, Ornella de Bari, Anthony Lembo, Sarah Ballou
Irritable bowel syndrome (IBS) is a chronic functional disorder of the gastrointestinal tract and is one of the most commonly diagnosed gastrointestinal diseases. The impact of IBS on the general population is large due to its high prevalence, suboptimal medical treatments and significant economic burden. The pathophysiology of IBS is complex and treatments are often symptom-specific. The most common therapeutic approaches for IBS include education and reassurance, lifestyles (especially nutrition-based interventions), peripherally acting medications (which typically target motility), centrally acting medications (which target visceral hypersensitivity and pain) and psychological interventions (which aim to reduce the effects of stress or symptom-specific anxiety)...
January 20, 2017: Gastroenterology Report
https://www.readbyqxmd.com/read/28089997/the-impact-of-age-and-sex-on-in-hospital-outcomes-of-chronic-total-occlusion-percutaneous-coronary-intervention
#8
Aris Karatasakis, Rahel Iwnetu, Barbara A Danek, Dimitri Karmpaliotis, Khaldoon Alaswad, Farouc A Jaffer, Robert W Yeh, David E Kandzari, Nicholas J Lembo, Mitul Patel, Ehtisham Mahmud, William L Lombardi, R Michael Wyman, J Aaron Grantham, Anthony H Doing, Catalin Toma, James W Choi, Barry F Uretsky, Jeffrey W Moses, Ajay J Kirtane, Ziad A Ali, Manish Parikh, Judit Karacsonyi, Bavana V Rangan, Craig A Thompson, Subhash Banerjee, Emmanouil S Brilakis
OBJECTIVES: We sought to determine the effect of age and sex on procedural outcomes and efficiency of chronic total occlusion (CTO) percutaneous coronary intervention (PCI). METHODS: We examined the clinical and angiographic characteristics and outcomes of 1675 CTO-PCIs performed in 1644 patients between 2012 and 2016 at 15 United States centers. RESULTS: Mean age was 65.3 ± 10 years and 1408 (86%) were men. Overall technical and procedural success rates were 88% and 87%, respectively...
April 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/27970311/tct-15-use-of-antegrade-dissection-re-entry-in-coronary-chronic-total-occlusion-percutaneous-coronary-intervention-in-a-contemporary-multicenter-registry
#9
Barbara Anna Danek, Aris Karatasakis, Dimitri Karmpaliotis, Khaldoon Alaswad, Robert Yeh, Farouc Jaffer, Mitul Patel, John Bahadorani, William Lombardi, R Michael Wyman, J Aaron Grantham, Anthony Doing, David Kandzari, Nicholas Lembo, Santiago Garcia, Catalin Toma, Jeffrey Moses, Ajay Kirtane, Manish Parikh, Ziad Ali, Judit Karacsonyi, Aya Alame, Phuong-Khanh Nguyen-Trong, Jose Roberto Martinez-Parachini, Pratik Kalsaria, Bavana Rangan, Craig Thompson, Subhash Banerjee, Emmanouil Brilakis
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27969943/tct-572-use-of-intravascular-imaging-during-chronic-total-occlusion-percutaneous-coronary-intervention-insights-from-a-contemporary-multicenter-registry
#10
Judit Karacsonyi, Khaldoon Alaswad, Farouc Jaffer, Robert Yeh, Mitul Patel, John Bahadorani, Barbara Anna Danek, Aris Karatasakis, Anthony Doing, J Aaron Grantham, Dimitri Karmpaliotis, Jeffrey Moses, Ajay Kirtane, Manish Parikh, Ziad Ali, William Lombardi, David Kandzari, Nicholas Lembo, Santiago Garcia, R Michael Wyman, Aya Alame, Jose Roberto Martinez-Parachini, Phuong-Khanh Nguyen-Trong, Erica Resendes, Pratik Kalsaria, Bavana Rangan, Imre Ungi, Craig Thompson, Subhash Banerjee, Emmanouil Brilakis
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27969651/tct-308-impact-of-race-and-ethnicity-on-technical-and-in-hospital-outcomes-following-chronic-total-occlusions-percutaneous-coronary-intervention
#11
Erica Resendes, Dimitri Karmpaliotis, Khaldoon Alaswad, Farouc Jaffer, Robert Yeh, R Michael Wyman, Mitul Patel, John Bahadorani, William Lombardi, J Aaron Grantham, David Kandzari, Nicholas Lembo, Jeffrey Moses, Ajay Kirtane, Catalin Toma, Anthony Doing, James Choi, Barry Uretsky, Aya Alame, Judit Karacsonyi, Barbara Anna Danek, Michael Smith, Aris Karatasakis, Bavana Rangan, Subhash Banerjee, Emmanouil Brilakis
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27969644/tct-301-outcomes-of-percutaneous-coronary-intervention-in-chronic-total-occlusions-caused-by-in-stent-restenosis-insights-from-a-u-s-multicenter-registry
#12
Aya Alame, Dimitri Karmpaliotis, Khaldoon Alaswad, Farouc Jaffer, Robert Yeh, R Michael Wyman, Mitul Patel, John Bahadorani, William Lombardi, J Aaron Grantham, David Kandzari, Nicholas Lembo, Jeffrey Moses, Ajay Kirtane, Catalin Toma, Anthony Doing, James Choi, Barry Uretsky, Judit Karacsonyi, Erica Resendes, Phuong-Khanh Nguyen-Trong, Jose Roberto Martinez-Parachini, Aris Karatasakis, Barbara Anna Danek, Bavana Rangan, Craig Thompson, Subhash Banerjee, Emmanouil Brilakis
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27969631/tct-289-comparison-of-various-scores-for-predicting-success-and-efficiency-of-chronic-total-occlusion-percutaneous-coronary-intervention
#13
Aris Karatasakis, Barbara Anna Danek, Dimitri Karmpaliotis, Khaldoon Alaswad, Farouc Jaffer, Robert Yeh, Mitul Patel, John Bahadorani, William Lombardi, R Michael Wyman, J Aaron Grantham, David Kandzari, Nicholas Lembo, Anthony Doing, Catalin Toma, Jeffrey Moses, Ajay Kirtane, Manish Parikh, Ziad Ali, Santiago Garcia, Pratik Kalsaria, Judit Karacsonyi, Aya Alame, Craig Thompson, Subhash Banerjee, Emmanouil Brilakis
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27969623/tct-281-development-and-validation-of-a-scoring-system-for-predicting-major-adverse-cardiovascular-events-during-percutaneous-coronary-interventions-of-chronic-total-occlusions-the-progress-cto-prospective-global-registry-for-the-study-of-chronic-total-occlusion
#14
Barbara Anna Danek, Aris Karatasakis, Dimitri Karmpaliotis, Khaldoon Alaswad, Robert Yeh, Farouc Jaffer, Mitul Patel, John Bahadorani, William Lombardi, R Michael Wyman, J Aaron Grantham, Anthony Doing, David Kandzari, Nicholas Lembo, Santiago Garcia, Catalin Toma, Jeffrey Moses, Ajay Kirtane, Manish Parikh, Ziad Ali, Judit Karacsonyi, Aya Alame, Phuong-Khanh Nguyen-Trong, Jose Roberto Martinez-Parachini, Pratik Kalsaria, Bavana Rangan, Craig Thompson, Subhash Banerjee, Emmanouil Brilakis
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27969620/tct-278-application-and-outcomes-of-the-hybrid-approach-to-chronic-total-occlusion-percutaneous-coronary-intervention-an-update-from-a-contemporary-multicenter-us-registry
#15
Aris Karatasakis, Barbara Anna Danek, Dimitri Karmpaliotis, Khaldoon Alaswad, Farouc Amin Jaffer, Robert Yeh, David Kandzari, Nicholas Lembo, Mitul Patel, John Bahadorani, William Lombardi, R Michael Wyman, J Aaron Grantham, Anthony Doing, Catalin Toma, James Choi, Barry Uretsky, Santiago Garcia, Jeffrey Moses, Ajay Kirtane, Ziad Ali, Manish Parikh, Judit Karacsonyi, Bavana Rangan, Craig Thompson, Subhash Banerjee, Emmanouil Brilakis
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27969614/tct-273-predictors-of-successful-stingray-assisted-antegrade-dissection-reentry-data-from-the-progress-cto-registry
#16
Catalin Toma, Aris Karatasakis, Dimitri Karmpaliotis, Khaldoon Alaswad, Robert Yeh, Farouc Jaffer, David Kandzari, Nicholas Lembo, William Lombardi, J Aaron Grantham, R Michael Wyman, Anthony Doing, Mitul Patel, John Bahadorani, Jeffrey Moses, Ajay Kirtane, Ziad Ali, Barbara Anna Danek, Judit Karacsonyi, Bavana Rangan, Subhash Banerjee, Emmanouil Brilakis
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27934609/approaches-to-percutaneous-coronary-intervention-of-right-coronary-artery-chronic-total-occlusions-insights-from-a-multicentre-us-registry
#17
Aris Karatasakis, Dimitri Karmpaliotis, Khaldoon Alaswad, Farouc A Jaffer, Robert W Yeh, Mitul P Patel, John N Bahadorani, William L Lombardi, R Michael Wyman, J Aaron Grantham, David E Kandzari, Nicholas J Lembo, Anthony H Doing, Catalin Toma, Jeffrey W Moses, Ajay J Kirtane, Ziad Ali, Manish Parikh, Santiago Garcia, Barbara A Danek, Judit Karacsonyi, Aya Alame, Pratik Kalsaria, Craig Thompson, Subhash Banerjee, Emmanouil S Brilakis
AIMS: The goal of this study was to describe the procedural characteristics, strategy selection and associated technical and efficiency outcomes for chronic total occlusion (CTO) percutaneous coronary intervention (PCI) of the right coronary artery (RCA). METHODS AND RESULTS: We examined the clinical and angiographic characteristics of patients who underwent RCA CTO PCI between 2012 and 2015 at 11 centres in the USA. The RCA was the CTO target vessel in 739 of 1,308 CTO PCIs (56%)...
December 10, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27797291/everolimus-eluting-stents-or-bypass-surgery-for-left-main-coronary-artery-disease
#18
RANDOMIZED CONTROLLED TRIAL
Gregg W Stone, Joseph F Sabik, Patrick W Serruys, Charles A Simonton, Philippe Généreux, John Puskas, David E Kandzari, Marie-Claude Morice, Nicholas Lembo, W Morris Brown, David P Taggart, Adrian Banning, Béla Merkely, Ferenc Horkay, Piet W Boonstra, Ad J van Boven, Imre Ungi, Gabor Bogáts, Samer Mansour, Nicolas Noiseux, Manel Sabaté, José Pomar, Mark Hickey, Anthony Gershlick, Pawel Buszman, Andrzej Bochenek, Erick Schampaert, Pierre Pagé, Ovidiu Dressler, Ioanna Kosmidou, Roxana Mehran, Stuart J Pocock, A Pieter Kappetein
BACKGROUND: Patients with obstructive left main coronary artery disease are usually treated with coronary-artery bypass grafting (CABG). Randomized trials have suggested that drug-eluting stents may be an acceptable alternative to CABG in selected patients with left main coronary disease. METHODS: We randomly assigned 1905 eligible patients with left main coronary artery disease of low or intermediate anatomical complexity to undergo either percutaneous coronary intervention (PCI) with fluoropolymer-based cobalt-chromium everolimus-eluting stents (PCI group, 948 patients) or CABG (CABG group, 957 patients)...
December 8, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27729332/development-and-validation-of-a-scoring-system-for-predicting-periprocedural-complications-during-percutaneous-coronary-interventions-of-chronic-total-occlusions-the-prospective-global-registry-for-the-study-of-chronic-total-occlusion-intervention-progress
#19
Barbara Anna Danek, Aris Karatasakis, Dimitri Karmpaliotis, Khaldoon Alaswad, Robert W Yeh, Farouc A Jaffer, Mitul P Patel, Ehtisham Mahmud, William L Lombardi, Michael R Wyman, J Aaron Grantham, Anthony Doing, David E Kandzari, Nicholas J Lembo, Santiago Garcia, Catalin Toma, Jeffrey W Moses, Ajay J Kirtane, Manish A Parikh, Ziad A Ali, Judit Karacsonyi, Bavana V Rangan, Craig A Thompson, Subhash Banerjee, Emmanouil S Brilakis
BACKGROUND: High success rates are achievable for chronic total occlusion (CTO) percutaneous coronary intervention (PCI) using the hybrid approach, but periprocedural complications remain of concern. Although scores estimating success and efficiency in CTO PCI have been developed, there is currently no available score for estimation of the risk for periprocedural complications. We sought to develop a scoring tool for prediction of periprocedural complications during CTO PCI. METHODS AND RESULTS: We analyzed data from 1569 CTO PCIs in the Prospective Global Registry for the Study of Chronic Total Occlusion Intervention (PROGRESS CTO) using a derivation and validation sampling ratio of 2:1...
October 11, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27705889/impact-of-proximal-cap-ambiguity-on-outcomes-of-chronic-total-occlusion-percutaneous-coronary-intervention-insights-from-a-multicenter-us-registry
#20
Aris Karatasakis, Barbara A Danek, Dimitri Karmpaliotis, Khaldoon Alaswad, Farouc A Jaffer, Robert W Yeh, Mitul P Patel, John N Bahadorani, R Michael Wyman, William L Lombardi, J Aaron Grantham, David E Kandzari, Nicholas J Lembo, Anthony H Doing, Jeffrey W Moses, Ajay J Kirtane, Santiago Garcia, Manish A Parikh, Ziad A Ali, Judit Karacsonyi, Sanjog Kalra, Bavana V Rangan, Pratik Kalsaria, Craig A Thompson, Subhash Banerjee, Emmanouil S Brilakis
OBJECTIVES: We sought to determine the impact of proximal cap ambiguity on procedural techniques and outcomes for coronary chronic total occlusion (CTO) percutaneous coronary intervention (PCI). METHODS: We examined the clinical and angiographic characteristics and outcomes of 1021 CTO-PCIs performed between 2012 and 2015 at 11 United States centers. RESULTS: Proximal cap ambiguity was present in 31% of target lesions and was associated with increased clinical and angiographic complexity (prior coronary artery bypass graft surgery: 43% vs 33%; P=...
October 2016: Journal of Invasive Cardiology
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