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Anthony Lembo

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https://www.readbyqxmd.com/read/27797291/everolimus-eluting-stents-or-bypass-surgery-for-left-main-coronary-artery-disease
#1
Gregg W Stone, Joseph F Sabik, Patrick W Serruys, Charles A Simonton, Philippe Généreux, John Puskas, David E Kandzari, Marie-Claude Morice, Nicholas Lembo, W Morris Brown, David P Taggart, Adrian Banning, Béla Merkely, Ferenc Horkay, Piet W Boonstra, Ad J van Boven, Imre Ungi, Gabor Bogáts, Samer Mansour, Nicolas Noiseux, Manel Sabaté, José Pomar, Mark Hickey, Anthony Gershlick, Pawel Buszman, Andrzej Bochenek, Erick Schampaert, Pierre Pagé, Ovidiu Dressler, Ioanna Kosmidou, Roxana Mehran, Stuart J Pocock, A Pieter Kappetein
Background Patients with obstructive left main coronary artery disease are usually treated with coronary-artery bypass grafting (CABG). Randomized trials have suggested that drug-eluting stents may be an acceptable alternative to CABG in selected patients with left main coronary disease. Methods We randomly assigned 1905 eligible patients with left main coronary artery disease of low or intermediate anatomical complexity to undergo either percutaneous coronary intervention (PCI) with fluoropolymer-based cobalt-chromium everolimus-eluting stents (PCI group, 948 patients) or CABG (CABG group, 957 patients)...
October 31, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27729332/development-and-validation-of-a-scoring-system-for-predicting-periprocedural-complications-during-percutaneous-coronary-interventions-of-chronic-total-occlusions-the-prospective-global-registry-for-the-study-of-chronic-total-occlusion-intervention-progress
#2
Barbara Anna Danek, Aris Karatasakis, Dimitri Karmpaliotis, Khaldoon Alaswad, Robert W Yeh, Farouc A Jaffer, Mitul P Patel, Ehtisham Mahmud, William L Lombardi, Michael R Wyman, J Aaron Grantham, Anthony Doing, David E Kandzari, Nicholas J Lembo, Santiago Garcia, Catalin Toma, Jeffrey W Moses, Ajay J Kirtane, Manish A Parikh, Ziad A Ali, Judit Karacsonyi, Bavana V Rangan, Craig A Thompson, Subhash Banerjee, Emmanouil S Brilakis
BACKGROUND: High success rates are achievable for chronic total occlusion (CTO) percutaneous coronary intervention (PCI) using the hybrid approach, but periprocedural complications remain of concern. Although scores estimating success and efficiency in CTO PCI have been developed, there is currently no available score for estimation of the risk for periprocedural complications. We sought to develop a scoring tool for prediction of periprocedural complications during CTO PCI. METHODS AND RESULTS: We analyzed data from 1569 CTO PCIs in the Prospective Global Registry for the Study of Chronic Total Occlusion Intervention (PROGRESS CTO) using a derivation and validation sampling ratio of 2:1...
October 11, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27705889/impact-of-proximal-cap-ambiguity-on-outcomes-of-chronic-total-occlusion-percutaneous-coronary-intervention-insights-from-a-multicenter-us-registry
#3
Aris Karatasakis, Barbara A Danek, Dimitri Karmpaliotis, Khaldoon Alaswad, Farouc A Jaffer, Robert W Yeh, Mitul P Patel, John N Bahadorani, R Michael Wyman, William L Lombardi, J Aaron Grantham, David E Kandzari, Nicholas J Lembo, Anthony H Doing, Jeffrey W Moses, Ajay J Kirtane, Santiago Garcia, Manish A Parikh, Ziad A Ali, Judit Karacsonyi, Sanjog Kalra, Bavana V Rangan, Pratik Kalsaria, Craig A Thompson, Subhash Banerjee, Emmanouil S Brilakis
OBJECTIVES: We sought to determine the impact of proximal cap ambiguity on procedural techniques and outcomes for coronary chronic total occlusion (CTO) percutaneous coronary intervention (PCI). METHODS: We examined the clinical and angiographic characteristics and outcomes of 1021 CTO-PCIs performed between 2012 and 2015 at 11 United States centers. RESULTS: Proximal cap ambiguity was present in 31% of target lesions and was associated with increased clinical and angiographic complexity (prior coronary artery bypass graft surgery: 43% vs 33%; P=...
October 2016: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/27611917/comparison-of-various-scores-for-predicting-success-of-chronic-total-occlusion-percutaneous-coronary-intervention
#4
Aris Karatasakis, Barbara A Danek, Dimitri Karmpaliotis, Khaldoon Alaswad, Farouc A Jaffer, Robert W Yeh, Mitul Patel, John N Bahadorani, William L Lombardi, R Michael Wyman, J Aaron Grantham, David E Kandzari, Nicholas J Lembo, Anthony H Doing, Catalin Toma, Jeffrey W Moses, Ajay J Kirtane, Manish A Parikh, Ziad A Ali, Santiago Garcia, Pratik Kalsaria, Judit Karacsonyi, Aya J Alame, Craig A Thompson, Subhash Banerjee, Emmanouil S Brilakis
BACKGROUND: Various scoring systems have been developed to predict the technical outcome and procedural efficiency of chronic total occlusion (CTO) percutaneous coronary intervention (PCI). METHODS: We examined the predictive capacity of 3 CTO PCI scores (Clinical and Lesion-related [CL], Multicenter CTO registry in Japan [J-CTO] and Prospective Global Registry for the Study of Chronic Total Occlusion Intervention [PROGRESS CTO] scores) in 664 CTO PCIs performed between 2012 and 2016 at 13 US centers...
August 23, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27543800/use-of-intravascular-imaging-during-chronic-total-occlusion-percutaneous-coronary-intervention-insights-from-a-contemporary-multicenter-registry
#5
Judit Karacsonyi, Khaldoon Alaswad, Farouc A Jaffer, Robert W Yeh, Mitul Patel, John Bahadorani, Aris Karatasakis, Barbara A Danek, Anthony Doing, J Aaron Grantham, Dimitri Karmpaliotis, Jeffrey W Moses, Ajay Kirtane, Manish Parikh, Ziad Ali, William L Lombardi, David E Kandzari, Nicholas Lembo, Santiago Garcia, Michael R Wyman, Aya Alame, Phuong-Khanh J Nguyen-Trong, Erica Resendes, Pratik Kalsaria, Bavana V Rangan, Imre Ungi, Craig A Thompson, Subhash Banerjee, Emmanouil S Brilakis
BACKGROUND: Intravascular imaging can facilitate chronic total occlusion (CTO) percutaneous coronary intervention. METHODS AND RESULTS: We examined the frequency of use and outcomes of intravascular imaging among 619 CTO percutaneous coronary interventions performed between 2012 and 2015 at 7 US centers. Mean age was 65.4±10 years and 85% of the patients were men. Intravascular imaging was used in 38%: intravascular ultrasound in 36%, optical coherence tomography in 3%, and both in 1...
2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27528177/repeat-treatment-with-rifaximin-is-safe-and-effective-in-patients-with-diarrhea-predominant-irritable-bowel-syndrome
#6
Anthony Lembo, Mark Pimentel, Satish S Rao, Philip Schoenfeld, Brooks Cash, Leonard B Weinstock, Craig Paterson, Enoch Bortey, William P Forbes
BACKGROUND & AIMS: Few treatments have demonstrated efficacy and safety for diarrhea-predominant irritable bowel syndrome (IBS-D). A phase 3, randomized, double-blind, placebo-controlled trial was performed to evaluate the safety and efficacy of repeat treatment with the nonsystemic antibiotic rifaximin. METHODS: The trial included adults with IBS-D, mean abdominal pain and bloating scores of 3 or more, and loose stool, located at 270 centers in the United States and Europe from February 2012 through June 2014...
December 2016: Gastroenterology
https://www.readbyqxmd.com/read/27479120/bat-trait-genetic-and-pathogen-data-from-large-scale-investigations-of-african-fruit-bats-eidolon-helvum
#7
COMMENT
Alison J Peel, Kate S Baker, David T S Hayman, Richard Suu-Ire, Andrew C Breed, Guy-Crispin Gembu, Tiziana Lembo, Andrés Fernández-Loras, David R Sargan, Anthony R Fooks, Andrew A Cunningham, James L N Wood
Bats, including African straw-coloured fruit bats (Eidolon helvum), have been highlighted as reservoirs of many recently emerged zoonotic viruses. This common, widespread and ecologically important species was the focus of longitudinal and continent-wide studies of the epidemiological and ecology of Lagos bat virus, henipaviruses and Achimota viruses. Here we present a spatial, morphological, demographic, genetic and serological dataset encompassing 2827 bats from nine countries over an 8-year period. Genetic data comprises cytochrome b mitochondrial sequences (n=608) and microsatellite genotypes from 18 loci (n=544)...
2016: Scientific Data
https://www.readbyqxmd.com/read/27476986/effect-of-lesion-age-on-outcomes-of-chronic-total-occlusion-percutaneous-coronary-intervention-insights-from-a-contemporary-us-multicenter-registry
#8
Barbara A Danek, Aris Karatasakis, Dimitri Karmpaliotis, Khaldoon Alaswad, Farouc A Jaffer, Robert W Yeh, Mitul P Patel, John Bahadorani, William L Lombardi, R Michael Wyman, J Aaron Grantham, David E Kandzari, Nicholas J Lembo, Anthony H Doing, Catalin Toma, Jeffrey W Moses, Ajay J Kirtane, Ziad A Ali, Manish Parikh, Santiago Garcia, Phuong-Khanh Nguyen-Trong, Judit Karacsonyi, Aya J Alame, Pratik Kalsaria, Craig Thompson, Subhash Banerjee, Emmanouil S Brilakis
BACKGROUND: We sought to determine the effect of lesion age on procedural techniques and outcomes of chronic total occlusion (CTO) percutaneous coronary intervention (PCI). METHODS: We examined the characteristics and outcomes of 394 CTO PCIs with data on lesion age, performed between 2012 and 2016 at 11 experienced US centres. RESULTS: Mean patient age was 66 ± 10 years and 85.6% of the patients were men. Overall technical and procedural success rates were 90...
December 2016: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/27342206/contrast-utilization-during-chronic-total-occlusion-percutaneous-coronary-intervention-insights-from-a-contemporary-multicenter-registry
#9
Georgios E Christakopoulos, Dimitri Karmpaliotis, Khaldoon Alaswad, Robert W Yeh, Farouc A Jaffer, R Michael Wyman, William Lombardi, J Aaron Grantham, David A Kandzari, Nicholas Lembo, Jeffrey W Moses, Ajay Kirtane, Manish Parikh, Philip Green, Matthew Finn, Santiago Garcia, Anthony Doing, Mitul Patel, John Bahadorani, Georgios Christopoulos, Aris Karatasakis, Craig A Thompson, Subhash Banerjee, Emmanouil S Brilakis
BACKGROUND: Administration of a large amount of contrast volume during chronic total occlusion (CTO) percutaneous coronary intervention (PCI) may lead to contrast-induced nephropathy. METHODS: We examined the association of clinical, angiographic and procedural variables with contrast volume administered during 1330 CTO-PCI procedures performed at 12 experienced United States centers. RESULTS: Technical and procedural success was 90% and 88%, respectively, and mean contrast volume was 289 ± 138 mL...
July 2016: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/27307562/outcomes-with-the-use-of-the-retrograde-approach-for-coronary-chronic-total-occlusion-interventions-in-a-contemporary-multicenter-us-registry
#10
Dimitri Karmpaliotis, Aris Karatasakis, Khaldoon Alaswad, Farouc A Jaffer, Robert W Yeh, R Michael Wyman, William L Lombardi, J Aaron Grantham, David E Kandzari, Nicholas J Lembo, Anthony Doing, Mitul Patel, John N Bahadorani, Jeffrey W Moses, Ajay J Kirtane, Manish Parikh, Ziad A Ali, Sanjog Kalra, Phuong-Khanh J Nguyen-Trong, Barbara A Danek, Judit Karacsonyi, Bavana V Rangan, Michele K Roesle, Craig A Thompson, Subhash Banerjee, Emmanouil S Brilakis
BACKGROUND: We sought to examine the efficacy and safety of chronic total occlusion percutaneous coronary intervention using the retrograde approach. METHODS AND RESULTS: We compared the outcomes of the retrograde versus antegrade-only approach to chronic total occlusion percutaneous coronary intervention among 1301 procedures performed at 11 experienced US centers between 2012 and 2015. The mean age was 65.5±10 years, and 84% of the patients were men with a high prevalence of diabetes mellitus (45%) and previous coronary artery bypass graft surgery (34%)...
June 2016: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/27184465/guidewire-and-microcatheter-utilization-patterns-during-antegrade-wire-escalation-in-chronic-total-occlusion-percutaneous-coronary-intervention-insights-from-a-contemporary-multicenter-registry
#11
Aris Karatasakis, Muhammad Nauman J Tarar, Dimitri Karmpaliotis, Khaldoon Alaswad, Robert W Yeh, Farouc A Jaffer, R Michael Wyman, William L Lombardi, J Aaron Grantham, David E Kandzari, Nicholas J Lembo, Jeffrey W Moses, Ajay J Kirtane, Manish Parikh, Santiago Garcia, Anthony Doing, Ashish Pershad, Alpesh Shah, Mitul Patel, John Bahadorani, Charles A Shoultz, Barbara A Danek, Craig A Thompson, Subhash Banerjee, Emmanouil S Brilakis
OBJECTIVES: We sought to describe contemporary guidewire and microcatheter utilization for antegrade wire escalation (AWE) during chronic total occlusion (CTO) percutaneous coronary intervention (PCI). BACKGROUND: Equipment utilization for AWE has been variable and evolving over time. METHODS: We examined device utilization during 694 AWE attempts in 679 patients performed at 15 experienced US centers between May 2012 and April 2015. RESULTS: Mean age was 65...
May 17, 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/27144634/rome-iv-diagnostic-questionnaires-and-tables-for-investigators-and-clinicians
#12
Olafur S Palsson, William E Whitehead, Miranda A L van Tilburg, Lin Chang, William Chey, Michael D Crowell, Laurie Keefer, Anthony J Lembo, Henry P Parkman, Satish Sc Rao, Ami Sperber, Brennan Spiegel, Jan Tack, Stephen Vanner, Lynn S Walker, Peter Whorwell, Yunsheng Yang
The Rome IV Diagnostic Questionnaires were developed to screen for functional gastrointestinal disorders (FGIDs), serve as inclusion criteria in clinical trials, and support epidemiological surveys. Separate questionnaires were developed for adults, children/adolescents, and infants/toddlers. For the adult questionnaire, we first surveyed 1,162 adults without gastrointestinal disorders, and recommended the 90(th) percentile symptom frequency as the threshold for defining what is abnormal. Diagnostic questions were formulated and verified with clinical experts using a recursive process...
February 13, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27144627/bowel-disorders
#13
Fermín Mearin, Brian E Lacy, Lin Chang, William D Chey, Anthony J Lembo, Magnus Simren, Robin Spiller
Functional bowel disorders are highly prevalent disorders found worldwide. These disorders have the potential to affect all members of society, regardless of age, gender, race, creed, color or socioeconomic status. Improving our understanding of functional bowel disorders (FBD) is critical as they impose a negative economic impact to the global health care system in addition to reducing quality of life. Research in the basic and clinical sciences during the past decade has produced new information on the epidemiology, etiology, pathophysiology, diagnosis and treatment of FBDs...
February 18, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27144621/pharmacological-pharmacokinetic-and-pharmacogenomic-aspects-of-functional-gastrointestinal-disorders
#14
Michael Camilleri, Lionel Bueno, Viola Andresen, Fabrizio De Ponti, Myung-Gyu Choi, Anthony Lembo
This article reviews medications commonly used for the treatment of patients with functional gastrointestinal disorders. Specifically, we review the animal models that have been validated for the study of drug effects on sensation and motility; the preclinical pharmacology, pharmacokinetics, and toxicology usually required for introduction of new drugs; the biomarkers that are validated for studies of sensation and motility endpoints with experimental medications in humans; the pharmacogenomics applied to these medications and their relevance to the FGIDs; and the pharmacology of agents that are applied or have potential for the treatment of FGIDs, including psychopharmacologic drugs...
February 18, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27088405/use-of-antegrade-dissection-re-entry-in-coronary-chronic-total-occlusion-percutaneous-coronary-intervention-in-a-contemporary-multicenter-registry
#15
Barbara Anna Danek, Aris Karatasakis, Dimitri Karmpaliotis, Khaldoon Alaswad, Robert W Yeh, Farouc A Jaffer, Mitul Patel, John Bahadorani, William L Lombardi, Michael R Wyman, J Aaron Grantham, Anthony Doing, Jeffrey W Moses, Ajay Kirtane, Manish Parikh, Ziad A Ali, Sanjog Kalra, David E Kandzari, Nicholas Lembo, Santiago Garcia, Bavana V Rangan, Craig A Thompson, Subhash Banerjee, Emmanouil S Brilakis
BACKGROUND: We assessed efficacy and safety of chronic total occlusion (CTO) percutaneous coronary intervention (PCI) using antegrade dissection re-entry (ADR). METHODS: We examined outcomes of ADR among 1313 CTO PCIs performed at 11 US centers between 2012-2015. RESULTS: 84.1% of patients were men. Prevalence of prior coronary artery bypass graft surgery was 34.3%. Overall technical and procedural success were 90.1% and 88.7%, respectively...
July 1, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27055601/relamorelin-reduces-vomiting-frequency-and-severity-and-accelerates-gastric-emptying-in-adults-with-diabetic-gastroparesis
#16
Anthony Lembo, Michael Camilleri, Richard McCallum, Ramon Sastre, Cristian Breton, Sharon Spence, Jeffery White, Michelle Currie, Keith Gottesdiener, Elizabeth Stoner
BACKGROUND & AIMS: Gastroparesis is an important complication of diabetes. We investigated the effects of relamorelin (a pentapeptide-selective agonist of the ghrelin receptor that speeds gastric emptying in patients with diabetes) in patients with diabetic gastroparesis. METHODS: We performed a double-blind trial of 204 patients (78% Caucasian; 67% female; mean age, 55 y; 88% with type 2 diabetes) with diabetic gastroparesis with moderate to severe symptoms and delayed gastric emptying at 27 clinical centers, from June 2012 until August 2013...
July 2016: Gastroenterology
https://www.readbyqxmd.com/read/26899493/effect-of-previous-failure-on-subsequent-procedural-outcomes-of-chronic-total-occlusion-percutaneous-coronary-intervention-from-a-contemporary-multicenter-registry
#17
MULTICENTER STUDY
Judit Karacsonyi, Aris Karatasakis, Dimitri Karmpaliotis, Khaldoon Alaswad, Robert W Yeh, Farouc A Jaffer, Michael R Wyman, William L Lombardi, J Aaron Grantham, David E Kandzari, Nicholas Lembo, Jeffrey W Moses, Ajay J Kirtane, Manish A Parikh, Philip Green, Matthew Finn, Santiago Garcia, Anthony Doing, Mitul Patel, John Bahadorani, Jose Roberto Martinez Parachini, Erica Resendes, Bavana V Rangan, Imre Ungi, Craig A Thompson, Subhash Banerjee, Emmanouil S Brilakis
We sought to examine the impact of previous failure on the outcomes of chronic total occlusion (CTO) percutaneous coronary intervention (PCI). We examined the clinical and angiographic characteristics and procedural outcomes of 1,213 consecutive patients who underwent 1,232 CTO PCIs from 2012 to 2015 at 12 US centers. Mean age was 65 ± 10 years, and 84.8% of patients were men. A previously failed attempt had been performed in 215 patients (17.5%). As compared with patients without previous CTO PCI failure, patients with previous failure had higher Multicenter CTO Registry in Japan CTO score (2...
April 15, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/26789872/eluxadoline-for-irritable-bowel-syndrome-with-diarrhea
#18
RANDOMIZED CONTROLLED TRIAL
Anthony J Lembo, Brian E Lacy, Marc J Zuckerman, Ron Schey, Leonard S Dove, David A Andrae, J Michael Davenport, Gail McIntyre, Rocio Lopez, Lisa Turner, Paul S Covington
Background Effective and safe treatments are needed for patients who have irritable bowel syndrome (IBS) with diarrhea. We conducted two phase 3 trials to assess the efficacy and safety of eluxadoline, a new oral agent with mixed opioid effects (μ- and κ-opioid receptor agonist and δ-opioid receptor antagonist), in patients with IBS with diarrhea. Methods We randomly assigned 2427 adults who had IBS with diarrhea to eluxadoline (at a dose of 75 mg or 100 mg) or placebo twice daily for 26 weeks (IBS-3002 trial) or 52 weeks (IBS-3001 trial)...
January 21, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/26669560/fecal-impaction-in-the-emergency-department-an-analysis-of-frequency-and-associated-charges-in-2011
#19
Caroline Corban, Thomas Sommers, Neil Sengupta, Mike Jones, Vivian Cheng, Elizabeth Friedlander, Andrea Bollom, Anthony Lembo
GOALS: The aim of this study was to analyze the incidence and associated charges of fecal impaction for trends in hospital and patient demographics in emergency departments (ED) across the United States. BACKGROUND: In 2010, an ICD-9-CM code (560.32) for fecal impaction was introduced, allowing for assessment of fecal impaction incidence. STUDY: Data were obtained from the National Emergency Department Sample records in which fecal impaction (ICD-9-CM code 560...
August 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/26582720/consensus-recommendations-on-initiating-prescription-therapies-for-opioid-induced-constipation
#20
REVIEW
Charles E Argoff, Michael J Brennan, Michael Camilleri, Andrew Davies, Jeffrey Fudin, Katherine E Galluzzi, Jeffrey Gudin, Anthony Lembo, Steven P Stanos, Lynn R Webster
OBJECTIVE: Aims of this consensus panel were to determine (1) an optimal symptom-based method for assessing opioid-induced constipation in clinical practice and (2) a threshold of symptom severity to prompt consideration of prescription therapy. METHODS: A multidisciplinary panel of 10 experts with extensive knowledge/experience with opioid-associated adverse events convened to discuss the literature on assessment methods used for opioid-induced constipation and reach consensus on each objective using the nominal group technique...
December 2015: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
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