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Anthony Lembo

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https://www.readbyqxmd.com/read/28545508/open-label-versus-double-blind-placebo-treatment-in-irritable-bowel-syndrome-study-protocol-for-a-randomized-controlled-trial
#1
Sarah Ballou, Ted J Kaptchuk, William Hirsch, Judy Nee, Johanna Iturrino, Kathryn T Hall, John M Kelley, Vivian Cheng, Irving Kirsch, Eric Jacobson, Lisa Conboy, Anthony Lembo, Roger B Davis
BACKGROUND: Placebo medications, by definition, are composed of inactive ingredients that have no physiological effect on symptoms. Nonetheless, administration of placebo in randomized controlled trials (RCTs) and in clinical settings has been demonstrated to have significant impact on many physical and psychological complaints. Until recently, conventional wisdom has suggested that patients must believe that placebo pills actually contain (or, at least, might possibly contain) active medication in order to elicit a response to placebo...
May 25, 2017: Trials
https://www.readbyqxmd.com/read/28529168/opioids-in-gastroenterology-treating-adverse-effects-and-creating-therapeutic-benefits
#2
Michael Camilleri, Anthony Lembo, David A Katzka
The use of opioid medications on both an acute and chronic basis is ubiquitous in the U.S. As opioid receptors densely populate the gastrointestinal tract, symptoms and side effects can be expected in these patients. In the esophagus, dysmotility may result manifesting with dysphagia and a syndrome indistinguishable from primary achalasia. In the stomach, a marked delay in gastric emptying may ensue with postprandial nausea and early satiety. Postoperatively, particularly with abdominal surgery, opioid induced ileus may ensue...
May 18, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28528055/pseudoachalasia-secondary-to-thoracic-aortic-aneurysm
#3
Jorind Beqari, Anthony Lembo, Jon Critchlow, Allen Hamden, Michael S Kent
Pseudoachalasia is known to be associated with malignancy involving the gastroesophageal junction and after esophageal operations. We present a case of pseudoachalasia secondary to an aneurysm of the descending thoracic aorta and describe successful operative management.
June 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28499595/impact-of-calcium-on-chronic-total-occlusion-percutaneous-coronary-interventions
#4
Judit Karacsonyi, Dimitri Karmpaliotis, Khaldoon Alaswad, Farouc A Jaffer, Robert W Yeh, Mitul Patel, Ehtisham Mahmud, William Lombardi, Michael R Wyman, Anthony Doing, Jeffrey W Moses, Ajay Kirtane, Manish Parikh, Ziad Ali, David Kandzari, Nicholas Lembo, Santiago Garcia, Barbara A Danek, Aris Karatasakis, Erica Resendes, Pratik Kalsaria, Bavana V Rangan, Imre Ungi, Craig A Thompson, Subhash Banerjee, Emmanouil S Brilakis
We sought to examine the impact of calcific deposits on the outcomes of chronic total occlusion (CTO) percutaneous coronary intervention (PCI). The outcomes of 1,476 consecutive CTO PCIs performed in 1,453 patients (65.5 ± 10 years, 85% male) between 2012 and 2016 at 11 US centers were evaluated. Moderate or severe quantity of calcium was present in 58% of target lesions. Calcified lesions were more tortuous and more likely to have proximal cap ambiguity and interventional collaterals. PCI of moderately/severely calcified CTOs more often required use of the retrograde approach (54% vs 30%, p <0...
April 13, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28451914/assessment-of-anti-vinculin-and-anti-cytolethal-distending-toxin-b-antibodies-in-subtypes-of-irritable-bowel-syndrome
#5
Ali Rezaie, Sung Chul Park, Walter Morales, Emily Marsh, Anthony Lembo, Jae Hak Kim, Stacy Weitsman, Kathleen S Chua, Gillian M Barlow, Mark Pimentel
BACKGROUND: Antibodies to cytolethal distending toxin B (CdtB) and vinculin are novel biomarkers that rule-in and differentiate irritable bowel syndrome with diarrhea (IBS-D) from other causes of diarrhea and healthy controls. AIM: To determine whether these antibodies can also diagnose and differentiate other IBS subtypes. METHODS: Subjects with IBS-D based on Rome III criteria (n = 2375) were recruited from a large-scale multicenter clinical trial (TARGET 3)...
April 27, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28417992/eluxadoline-efficacy-in-ibs-d-patients-who-report-prior-loperamide-use
#6
Brian E Lacy, William D Chey, Brooks D Cash, Anthony J Lembo, Leonard S Dove, Paul S Covington
OBJECTIVES: Irritable bowel syndrome with diarrhea (IBS-D) is often managed with over-the-counter therapies such as loperamide, though with limited success. This analysis evaluated the efficacy of eluxadoline in patients previously treated with loperamide in two phase 3 studies. METHODS: Adults with IBS-D (Rome III criteria) were enrolled and randomized to placebo or eluxadoline (75 or 100 mg) twice daily for 26 (IBS-3002) or 52 (IBS-3001) weeks. Patients reported loperamide use over the previous year and recorded their rescue loperamide use during the studies...
April 18, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28332105/emergency-department-burden-of-diverticulitis-in-the-usa-2006-2013
#7
Andrea Bollom, Jasmine Austrie, William Hirsch, Judy Nee, Daniel Friedlander, Kelli Ellingson, Vivian Cheng, Anthony Lembo
GOALS: The aim of this study was to analyze recent trends in emergency department (ED) visits for diverticulitis between 2006 and 2013. BACKGROUND: Acute diverticulitis is a serious medical condition that frequently leads to ED visits, hospitalizations, and surgeries resulting in a significant health care burden. METHODS: Data were obtained from the National Emergency Department Sample (NEDS) records in which diverticulitis (ICD-9-CM codes 562...
March 22, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28323273/hydrogen-and-methane-based-breath-testing-in-gastrointestinal-disorders-the-north-american-consensus
#8
Ali Rezaie, Michelle Buresi, Anthony Lembo, Henry Lin, Richard McCallum, Satish Rao, Max Schmulson, Miguel Valdovinos, Salam Zakko, Mark Pimentel
OBJECTIVES: Breath tests (BTs) are important for the diagnosis of carbohydrate maldigestion syndromes and small intestinal bacterial overgrowth (SIBO). However, standardization is lacking regarding indications for testing, test methodology and interpretation of results. A consensus meeting of experts was convened to develop guidelines for clinicians and research. METHODS: Pre-meeting survey questions encompassing five domains; indications, preparation, performance, interpretation of results, and knowledge gaps, were sent to 17 clinician-scientists, and 10 attended a live meeting...
May 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28259791/irritable-bowel-syndrome-an-infectious-disease
#9
EDITORIAL
Eamonn M M Quigley, Anthony J Lembo
No abstract text is available yet for this article.
March 1, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28244495/tenapanor-treatment-of-patients-with-constipation-predominant-irritable-bowel-syndrome-a-phase-2-randomized-placebo-controlled-efficacy-and-safety-trial
#10
William D Chey, Anthony J Lembo, David P Rosenbaum
OBJECTIVES: Tenapanor is a first-in-class, small-molecule inhibitor of the gastrointestinal sodium/hydrogen exchanger NHE3. This study assessed the efficacy and safety of tenapanor in patients with constipation-predominant irritable bowel syndrome (IBS-C). METHODS: In this phase 2, double-blind study, patients with IBS-C (Rome III criteria) were randomized (1:1:1:1) to receive tenapanor 5 mg, 20 mg, or 50 mg b.i.d., or placebo b.i.d. for 12 weeks. The primary end point was the complete spontaneous bowel movement (CSBM) responder rate, defined as the proportion of patients reporting an increase from baseline of ≥1 CSBM/week for ≥6/12 treatment weeks...
May 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28169091/predictors-of-excess-patient-radiation-exposure-during-chronic-total-occlusion-coronary-intervention-insights-from-a-contemporary-multicentre-registry
#11
Georgios E Christakopoulos, Georgios Christopoulos, Dimitri Karmpaliotis, Khaldoon Alaswad, Robert W Yeh, Farouc A Jaffer, Michael R Wyman, William L Lombardi, Muhammad Nauman J Tarar, J Aaron Grantham, David E Kandzari, Nicholas Lembo, Jeffrey W Moses, Ajay J Kirtane, Manish Parikh, Philip Green, Matthew Finn, Santiago Garcia, Anthony H Doing, Raja Hatem, Craig A Thompson, Subhash Banerjee, Emmanouil S Brilakis
BACKGROUND: High patient radiation dose during chronic total occlusion (CTO) percutaneous coronary intervention (PCI) might lead to procedural failure and radiation skin injury. METHODS: We examined the association between several clinical and angiographic variables on patient air kerma (AK) radiation dose among 748 consecutive CTO PCIs performed at 9 experienced US centres between May 2012 and May 2015. RESULTS: The mean age was 65 ± 10 years, 87% of patients were men, and 35% had previous coronary artery bypass graft surgery (CABG)...
April 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28110300/irritable-bowel-syndrome-and-diet
#12
REVIEW
Piero Portincasa, Leonilde Bonfrate, Ornella de Bari, Anthony Lembo, Sarah Ballou
Irritable bowel syndrome (IBS) is a chronic functional disorder of the gastrointestinal tract and is one of the most commonly diagnosed gastrointestinal diseases. The impact of IBS on the general population is large due to its high prevalence, suboptimal medical treatments and significant economic burden. The pathophysiology of IBS is complex and treatments are often symptom-specific. The most common therapeutic approaches for IBS include education and reassurance, lifestyles (especially nutrition-based interventions), peripherally acting medications (which typically target motility), centrally acting medications (which target visceral hypersensitivity and pain) and psychological interventions (which aim to reduce the effects of stress or symptom-specific anxiety)...
January 20, 2017: Gastroenterology Report
https://www.readbyqxmd.com/read/28089997/the-impact-of-age-and-sex-on-in-hospital-outcomes-of-chronic-total-occlusion-percutaneous-coronary-intervention
#13
Aris Karatasakis, Rahel Iwnetu, Barbara A Danek, Dimitri Karmpaliotis, Khaldoon Alaswad, Farouc A Jaffer, Robert W Yeh, David E Kandzari, Nicholas J Lembo, Mitul Patel, Ehtisham Mahmud, William L Lombardi, R Michael Wyman, J Aaron Grantham, Anthony H Doing, Catalin Toma, James W Choi, Barry F Uretsky, Jeffrey W Moses, Ajay J Kirtane, Ziad A Ali, Manish Parikh, Judit Karacsonyi, Bavana V Rangan, Craig A Thompson, Subhash Banerjee, Emmanouil S Brilakis
OBJECTIVES: We sought to determine the effect of age and sex on procedural outcomes and efficiency of chronic total occlusion (CTO) percutaneous coronary intervention (PCI). METHODS: We examined the clinical and angiographic characteristics and outcomes of 1675 CTO-PCIs performed in 1644 patients between 2012 and 2016 at 15 United States centers. RESULTS: Mean age was 65.3 ± 10 years and 1408 (86%) were men. Overall technical and procedural success rates were 88% and 87%, respectively...
April 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/27970311/tct-15-use-of-antegrade-dissection-re-entry-in-coronary-chronic-total-occlusion-percutaneous-coronary-intervention-in-a-contemporary-multicenter-registry
#14
Barbara Anna Danek, Aris Karatasakis, Dimitri Karmpaliotis, Khaldoon Alaswad, Robert Yeh, Farouc Jaffer, Mitul Patel, John Bahadorani, William Lombardi, R Michael Wyman, J Aaron Grantham, Anthony Doing, David Kandzari, Nicholas Lembo, Santiago Garcia, Catalin Toma, Jeffrey Moses, Ajay Kirtane, Manish Parikh, Ziad Ali, Judit Karacsonyi, Aya Alame, Phuong-Khanh Nguyen-Trong, Jose Roberto Martinez-Parachini, Pratik Kalsaria, Bavana Rangan, Craig Thompson, Subhash Banerjee, Emmanouil Brilakis
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27969943/tct-572-use-of-intravascular-imaging-during-chronic-total-occlusion-percutaneous-coronary-intervention-insights-from-a-contemporary-multicenter-registry
#15
Judit Karacsonyi, Khaldoon Alaswad, Farouc Jaffer, Robert Yeh, Mitul Patel, John Bahadorani, Barbara Anna Danek, Aris Karatasakis, Anthony Doing, J Aaron Grantham, Dimitri Karmpaliotis, Jeffrey Moses, Ajay Kirtane, Manish Parikh, Ziad Ali, William Lombardi, David Kandzari, Nicholas Lembo, Santiago Garcia, R Michael Wyman, Aya Alame, Jose Roberto Martinez-Parachini, Phuong-Khanh Nguyen-Trong, Erica Resendes, Pratik Kalsaria, Bavana Rangan, Imre Ungi, Craig Thompson, Subhash Banerjee, Emmanouil Brilakis
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27969651/tct-308-impact-of-race-and-ethnicity-on-technical-and-in-hospital-outcomes-following-chronic-total-occlusions-percutaneous-coronary-intervention
#16
Erica Resendes, Dimitri Karmpaliotis, Khaldoon Alaswad, Farouc Jaffer, Robert Yeh, R Michael Wyman, Mitul Patel, John Bahadorani, William Lombardi, J Aaron Grantham, David Kandzari, Nicholas Lembo, Jeffrey Moses, Ajay Kirtane, Catalin Toma, Anthony Doing, James Choi, Barry Uretsky, Aya Alame, Judit Karacsonyi, Barbara Anna Danek, Michael Smith, Aris Karatasakis, Bavana Rangan, Subhash Banerjee, Emmanouil Brilakis
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27969644/tct-301-outcomes-of-percutaneous-coronary-intervention-in-chronic-total-occlusions-caused-by-in-stent-restenosis-insights-from-a-u-s-multicenter-registry
#17
Aya Alame, Dimitri Karmpaliotis, Khaldoon Alaswad, Farouc Jaffer, Robert Yeh, R Michael Wyman, Mitul Patel, John Bahadorani, William Lombardi, J Aaron Grantham, David Kandzari, Nicholas Lembo, Jeffrey Moses, Ajay Kirtane, Catalin Toma, Anthony Doing, James Choi, Barry Uretsky, Judit Karacsonyi, Erica Resendes, Phuong-Khanh Nguyen-Trong, Jose Roberto Martinez-Parachini, Aris Karatasakis, Barbara Anna Danek, Bavana Rangan, Craig Thompson, Subhash Banerjee, Emmanouil Brilakis
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27969631/tct-289-comparison-of-various-scores-for-predicting-success-and-efficiency-of-chronic-total-occlusion-percutaneous-coronary-intervention
#18
Aris Karatasakis, Barbara Anna Danek, Dimitri Karmpaliotis, Khaldoon Alaswad, Farouc Jaffer, Robert Yeh, Mitul Patel, John Bahadorani, William Lombardi, R Michael Wyman, J Aaron Grantham, David Kandzari, Nicholas Lembo, Anthony Doing, Catalin Toma, Jeffrey Moses, Ajay Kirtane, Manish Parikh, Ziad Ali, Santiago Garcia, Pratik Kalsaria, Judit Karacsonyi, Aya Alame, Craig Thompson, Subhash Banerjee, Emmanouil Brilakis
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27969623/tct-281-development-and-validation-of-a-scoring-system-for-predicting-major-adverse-cardiovascular-events-during-percutaneous-coronary-interventions-of-chronic-total-occlusions-the-progress-cto-prospective-global-registry-for-the-study-of-chronic-total-occlusion
#19
Barbara Anna Danek, Aris Karatasakis, Dimitri Karmpaliotis, Khaldoon Alaswad, Robert Yeh, Farouc Jaffer, Mitul Patel, John Bahadorani, William Lombardi, R Michael Wyman, J Aaron Grantham, Anthony Doing, David Kandzari, Nicholas Lembo, Santiago Garcia, Catalin Toma, Jeffrey Moses, Ajay Kirtane, Manish Parikh, Ziad Ali, Judit Karacsonyi, Aya Alame, Phuong-Khanh Nguyen-Trong, Jose Roberto Martinez-Parachini, Pratik Kalsaria, Bavana Rangan, Craig Thompson, Subhash Banerjee, Emmanouil Brilakis
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27969620/tct-278-application-and-outcomes-of-the-hybrid-approach-to-chronic-total-occlusion-percutaneous-coronary-intervention-an-update-from-a-contemporary-multicenter-us-registry
#20
Aris Karatasakis, Barbara Anna Danek, Dimitri Karmpaliotis, Khaldoon Alaswad, Farouc Amin Jaffer, Robert Yeh, David Kandzari, Nicholas Lembo, Mitul Patel, John Bahadorani, William Lombardi, R Michael Wyman, J Aaron Grantham, Anthony Doing, Catalin Toma, James Choi, Barry Uretsky, Santiago Garcia, Jeffrey Moses, Ajay Kirtane, Ziad Ali, Manish Parikh, Judit Karacsonyi, Bavana Rangan, Craig Thompson, Subhash Banerjee, Emmanouil Brilakis
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
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