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JOURNAL ARTICLE
Shaohua Shi, Minghui Zhang, Xuliang Chen, Zhuoyi Wang, Songming Ding, Zhitao Chen, Yu Yang, Shusen Zheng
No abstract text is available yet for this article.
April 17, 2024: Chinese Medical Journal
#2
EDITORIAL
Samriddhi Poyekar, Aabha Nagral
No abstract text is available yet for this article.
April 17, 2024: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
#3
REVIEW
Current status of preoperative endoscopic biliary drainage for distal and hilar biliary obstruction.
Hirotoshi Ishiwatari, Junya Sato, Hiroki Sakamoto, Takuya Doi, Hiroyuki Ono
The purpose of preoperative biliary drainage (PBD) is to reduce complications during the perioperative period. The extrahepatic bile duct comprises distal and hilar bile ducts and assessing the need for PBD must be considered separately for each duct, as surgical procedures and morbidities vary. The representative disease-causing distal bile duct obstruction is pancreatic cancer. A randomized controlled trial has revealed that PBD carries the risk of recurrent cholangitis and pancreatitis before surgery, thus eliminating the need for PBD when early surgery is feasible...
April 17, 2024: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
#4
JOURNAL ARTICLE
Boulkandoul Ramzi, Ameddah Souad, Chebbah Kawthar, Erenler Ramazan, Mekkiou Ratiba, Benayache Samir, Benayache Fadila, Menad Ahmed
OBJECTIVES: The current study was conducted to assess the protective mechanisms of n- BuOH fraction from the aerial part of Genista cephontala (BEGC) on APAP-induced liver injury compared to necrostatine-1 (Nec-1). MATERIALS AND METHODS: A model of APAP-induced hepatotoxicity was created in male rats by injecting a single dose; 1000 mg/kg APAP, the protective effect was performed with (200 mg/kg; 10 days) BEGC compared to Nec-1, (1.8 mg/kg). RESULTS: BEGC or NeC-1 pretreatment significantly abolished impaired effects in APAP-rats, by decreasing the generation of TBARS and ROS in mitochondrial and cytosolic fractions and maintaining liver function activities...
2024: Iranian Journal of Basic Medical Sciences
#5
JOURNAL ARTICLE
Johannes Hilberath, Vittoria Camelli, Christiane Hofer, Steffen Hartleif, Silvio Nadalin, Maren Peters, Matthias Kumpf, Andrea Bevot, Matthias Zirngibl, Marcus Weitz, Ekkehard Sturm
OBJECTIVES: Paediatric acute liver failure (PALF) is a life-threatening disease. Management aims to support hepatic regeneration or to bridge to liver transplantation. High-volume plasmapheresis (HVP) removes protein-bound substances, alleviates inflammation, and improves survival in adult acute liver failure. However, experience with HVP in PALF is limited. Aim of this study is to report on feasibility, safety, efficacy and outcomes of HVP in PALF. METHODS: Retrospective observational study in children with PALF...
April 16, 2024: Journal of Pediatric Gastroenterology and Nutrition
#6
REVIEW
Raed Obaid Saleh, Adnan Taan Alkhafaji, Jaafaru Sani Mohammed, Pooja Bansal, Harpreet Kaur, Irfan Ahmad, Ahmed Hjazi, Israa Hussein Mohammed, Mohammed Abed Jawad, Ahmed Hussein Zwamel
Nuclear paraspeckle assembly transcript 1 (NEAT1) is a long noncoding RNA (lncRNA) that is widely expressed in a variety of mammalian cell types. Altered expression levels of the lncRNA NEAT1 have been reported in liver-related disorders including cancer, fatty liver disease, liver fibrosis, viral hepatitis, and hepatic ischemia. lncRNA NEAT1 mostly acts as a competing endogenous RNA (ceRNA) to sponge various miRNAs (miRs) to regulate different functions. In regard to hepatic cancers, the elevated expression of NEAT1 has been reported to have a relation with the proliferation, migration, angiogenesis, apoptosis, as well as epithelial-mesenchymal transition (EMT) of cancer cells...
April 2024: Cell Biochemistry and Function
#7
JOURNAL ARTICLE
Tingting Zhan, Yuxiang Guan, Caijie Sun, Lili Wang, Yan Wang, Xiang Li
Wilson's disease is caused by abnormal copper metabolism resulting in deposition in various organs, including the brain, liver, and cornea, thus disrupting organ function. It is characterized by encephalopathy, extrapyramidal symptoms, progressive liver failure, and copper ring deposition in the cornea. Management of this disease should include quality of life maintenance; however, relevant studies on this topic are lacking. This study aimed to assess the factors affecting the quality of life (QoL) of patients with Wilson's disease...
April 15, 2024: Scientific Reports
#8
JOURNAL ARTICLE
Jinxia Liu, Jane MacNaughtan, Annarein J C Kerbert, Theo Portlock, Javier Martínez Gonzalez, Yi Jin, Frederick Clasen, Abeba Habtesion, Huoyan Ji, Qin Jin, Alexandra Phillips, Francesco De Chiara, Ganesh Ingavle, Cesar Jimenez, Giacomo Zaccherini, Katherine Husi, Miguel Angel Rodriguez Gandia, Paul Cordero, Junpei Soeda, Lynda McConaghy, Jude Oben, Karen Church, Jia V Li, Haifeng Wu, Aarti Jalan, Pere Gines, Elsa Solà, Simon Eaton, Carrie Morgan, Michal Kowalski, Daniel Green, Amir Gander, Lindsey A Edwards, I Jane Cox, Helena Cortez-Pinto, Thomas Avery, Reiner Wiest, Francois Durand, Paolo Caraceni, Roberto Elosua, Joan Vila, Marco Pavesi, Vicente Arroyo, Nathan Davies, Rajeshwar P Mookerjee, Victor Vargas, Susan Sandeman, Gautam Mehta, Saeed Shoaie, Julian Marchesi, Agustín Albillos, Fausto Andreola, Rajiv Jalan
OBJECTIVE: Targeting bacterial translocation in cirrhosis is limited to antibiotics with risk of antimicrobial resistance. This study explored the therapeutic potential of a non-absorbable, gut-restricted, engineered carbon bead adsorbent, Yaq-001 in models of cirrhosis and acute-on-chronic liver failure (ACLF) and, its safety and tolerability in a clinical trial in cirrhosis. DESIGN: Performance of Yaq-001 was evaluated in vitro . Two-rat models of cirrhosis and ACLF, (4 weeks, bile duct ligation with or without lipopolysaccharide), receiving Yaq-001 for 2 weeks; and two-mouse models of cirrhosis (6-week and 12-week carbon tetrachloride (CCl4)) receiving Yaq-001 for 6 weeks were studied...
April 15, 2024: Gut
#9
REVIEW
Douglas J Lanska
This article examines disagreements among three giants of twentieth-century American neurology: Raymond Adams, Joseph Foley, and Abraham Baker. The disagreements Adams and Foley had with Baker concerned two issues: (1) the neurologic and neuropathological manifestations of liver failure with hepatic encephalopathy as expounded from the late 1940s to the early 1960s, and (2) the founding of the American Academy of Neurology in 1948 as an inclusive medical society under the principal leadership of Baker. The conflicts are examined from transcribed meeting debates (1949-1963), salient original publications (1949-1963), public addresses of protagonists touching on these issues (1971, 1984), and oral histories and less formal interviews of the protagonists and their associates (1979-2014)...
April 15, 2024: Journal of the History of the Neurosciences
#10
JOURNAL ARTICLE
Balagangadhar R Totapally, Seevitha Totapalli, Prithvi Sendi, Paul A Martinez
OBJECTIVE: The study aimed to explore the prevalence, clinical features, resource utilization, temporal trends and outcomes associated with adenoviral infections in hospitalized children. METHODS: A retrospective analysis using the Healthcare Cost and Utilization Project's Kids' Inpatient Database from 1997 to 2019 was performed. Children aged 29 days to 17 years with adenoviral infection were selected. Chi-square, Kruskal-Wallis tests, linear trend analysis and multivariable analysis were used for data analysis...
April 11, 2024: Pediatric Infectious Disease Journal
#11
REVIEW
Yang Wang, Robim M Rodrigues, Cheng Chen, Dechun Feng, Luca Maccioni, Bin Gao
Healthy livers contain 80% of body resident macrophages known as Kupffer cells. In diseased livers, the number of Kupffer cells usually drops, but is compensated by infiltration of monocyte-derived macrophages, which can differentiate into Kupffer-like cells. Early studies suggest that Kupffer cells play important roles in both promoting liver injury as well as liver regeneration. Yet, the distinction of the functionalities from resident and infiltrating macrophages is not always made. By using more specific macrophage markers and targeted cell depletion and single cell RNA sequencing, recent studies revealed several subsets of monocyte-derived macrophages that play important functions in inducing liver damage and inflammation as well as in liver repair and regeneration...
April 15, 2024: American Journal of Physiology. Cell Physiology
#12
JOURNAL ARTICLE
Wenhan Fan, Wei Liao, Shengjun Jiang, Yi Chen, Chengzhong Li, Xuesong Liang
BACKGROUND/AIMS: Acute-on-chronic liver failure (ACLF) is associated with high short-term mortality, and early prediction is critical to reduce the deaths of ACLF patients. To date, however, the prognostic accuracy of current models for ACLF is unsatisfactory, particularly, in patients with hepatitis B virus (HBV) infection. This study aims to develop novel prognostic models based on the dynamic changes in variables to predict the short-term mortality of HBV-associated ACLF (HBV-ACLF)...
April 15, 2024: Heliyon
#13
EDITORIAL
Joshua Sheng Hao Lim, Vishal G Shelat
No abstract text is available yet for this article.
April 3, 2024: Hepatobiliary Surgery and Nutrition
#14
JOURNAL ARTICLE
Bin-Yong Liang, Er-Lei Zhang, Jian Li, Xin Long, Wen-Qiang Wang, Bi-Xiang Zhang, Zhi-Wei Zhang, Yi-Fa Chen, Wan-Guang Zhang, Bin Mei, Zhen-Yu Xiao, Jin Gu, Zun-Yi Zhang, Shuai Xiang, Han-Hua Dong, Lei Zhang, Peng Zhu, Qi Cheng, Lin Chen, Zhan-Guo Zhang, Bin-Hao Zhang, Wei Dong, Xiao-Feng Liao, Tao Yin, Dong-De Wu, Bin Jiang, Yu-Feng Yuan, Zhong-Lin Zhang, Yao-Bing Chen, Kai-Yan Li, Wan Yee Lau, Xiao-Ping Chen, Zhi-Yong Huang
BACKGROUND: Adequate evaluation of degrees of liver cirrhosis is essential in surgical treatment of hepatocellular carcinoma (HCC) patients. The impact of the degrees of cirrhosis on prediction of post-hepatectomy liver failure (PHLF) remains poorly defined. This study aimed to construct and validate a combined pre- and intra-operative nomogram based on the degrees of cirrhosis in predicting PHLF in HCC patients using prospective multi-center's data. METHODS: Consecutive HCC patients who underwent hepatectomy between May 18, 2019 and Dec 19, 2020 were enrolled at five tertiary hospitals...
April 3, 2024: Hepatobiliary Surgery and Nutrition
#15
JOURNAL ARTICLE
Xing-Nian Zhou, Quan Zhang, Hong Peng, Yu-Jie Qin, Yu-Hong Liu, Lu Wang, Ming-Liang Cheng, Xin-Hua Luo, Hong Li
BACKGROUND: Acute liver failure (ALF) has a high mortality with widespread hepatocyte death involving ferroptosis and pyroptosis. The silent information regulator sirtuin 1 (SIRT1)-mediated deacetylation affects multiple biological processes, including cellular senescence, apoptosis, sugar and lipid metabolism, oxidative stress, and inflammation. AIM: To investigate the association between ferroptosis and pyroptosis and the upstream regulatory mechanisms. METHODS: This study included 30 patients with ALF and 30 healthy individuals who underwent serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) testing...
March 21, 2024: World Journal of Gastroenterology: WJG
#16
JOURNAL ARTICLE
Deven Juneja, Ravi Jain, Prashant Nasa
BACKGROUND: Dengue fever is the most common cause of viral hemorrhagic fever, with more than 400 million cases being reported annually, worldwide. Even though hepatic involvement is common, acute liver failure (ALF) is a rare complication of dengue fever. AIM: To analyze the demographic profile, symptomology, hospital course and outcomes of patients presenting with ALF secondary to dengue infection by reviewing the published case reports. METHODS: A systematic search was performed from multiple databases including PubMed, Reference Citation Analysis , Science Direct, and Google Scholar...
March 25, 2024: World Journal of Virology
#17
JOURNAL ARTICLE
Runze Chen, Shiyi Peng, Qiming Xia, Tianxiang Wu, Junyan Zheng, Haiyan Qin, Jun Qian
Achieving high-resolution and large-depth microscopic imaging in vivo under conditions characterized by high-scattering and dense-labeling, as commonly encountered in the liver, poses a formidable challenge. Here, through the optimization of multi-photon fluorescence excitation window, tailored to the unique optical properties of the liver, intravital microscopic imaging of hepatocytes and hepatic blood vessels with high spatial resolution was attained. It's worth noting that resolution degradation caused by tissue scattering of excitation light was mitigated by accounting for moderate tissue self-absorption...
April 14, 2024: Journal of Biophotonics
#18
REVIEW
Ilaria Testa, Giuseppe Indolfi, Rossa Brugha, Henkjan J Verkade, Vito Terlizzi
BACKGROUND & AIMS: Cystic Fibrosis (CF) liver disease progresses to liver failure requiring transplantation in about 3 % of patients, 0.7 % of CF patients are post liver transplant. The prognosis of CF has improved with the introduction of elexacaftor/tezacaftor/ivacaftor (ETI). Due to the paucity of data and concerns regarding interactions with immunosuppressive drug regimens, there is no general consensus on use of ETI post liver transplantation. The aim of this review is to report the safety and efficacy of ETI in CF patients who underwent liver transplantation...
April 13, 2024: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
#19
REVIEW
Kathryn Olsen, Sara Mahgoub, Sarah Al-Shakhshir, Akram Algieder, Sowsan Atabani, Ayman Bannaga, Ahmed M Elsharkawy
Hepatitis D virus (HDV), also referred to as hepatitis delta virus, is the smallest virus capable of causing human disease. It is unable to replicate on its own and can only propagate in the presence of hepatitis B virus (HBV). Infection with both HBV and HDV frequently results in more severe disease than HBV alone, with higher instances of cirrhosis, liver failure and hepatocellular carcinoma (HCC). Thus, there is a need for effective treatment for HDV; however, currently approved treatment options are very limited both in terms of their efficacy and availability...
July 2023: Clinical Medicine: Journal of the Royal College of Physicians of London
#20
JOURNAL ARTICLE
David S Umbaugh, Nga T Nguyen, Sawyer H Smith, Anup Ramachandran, Hartmut Jaeschke
Fifty percent of all acute liver failure (ALF) cases in the United States are due to acetaminophen (APAP) overdose. Assessment of canonical features of liver injury, such as plasma alanine aminotransferase activities are poor predictors of acute liver failure (ALF), suggesting the involvement of additional mechanisms independent of hepatocyte death. Previous work demonstrated a severe overdose of APAP results in impaired regeneration, the induction of senescence by p21, and increased mortality. We hypothesized that a discrete population of p21+ hepatocytes acquired a secretory phenotype that directly impedes liver recovery after a severe APAP overdose...
April 11, 2024: Toxicology
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